Academic literature on the topic 'Cytotoxic styryl lactones'

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Journal articles on the topic "Cytotoxic styryl lactones"

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Wiart, Christophe. "GoniothalamusSpecies: A Source of Drugs for the Treatment of Cancers and Bacterial Infections?" Evidence-Based Complementary and Alternative Medicine 4, no. 3 (2007): 299–311. http://dx.doi.org/10.1093/ecam/nem009.

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Irrespective of the presence of cytotoxic acetogenins and styryl-lactones in the genusGoniothalamus, only 22 species in the genusGoniothalamus, out of 160 species (13.7%) have so far been investigated. In an effort to promote further research on the genusGoniothalamuswhich could represent a source of drugs for the treatment of cancers and bacterial infections, this work offers a broad analysis of current knowledge onGoniothalamusspecies. Therefore, it includes (i) taxonomy (ii) botanical description (iii) traditional medicinal uses and (iv) phytochemical and pharmacological studies. We discuss
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Babu Mereyala, Hari, and Maju Joe. "Cytotoxic Activity of Styryl Lactones and their Derivatives." Current Medicinal Chemistry-Anti-Cancer Agents 1, no. 3 (2001): 293–300. http://dx.doi.org/10.2174/1568011013354606.

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Rasol, Nurulfazlina Edayah, Fasihuddin Badruddin Ahmad, Chun-Wai Mai, et al. "Styryl Lactones from Roots and Barks Goniothalamus lanceolatus." Natural Product Communications 13, no. 12 (2018): 1934578X1801301. http://dx.doi.org/10.1177/1934578x1801301203.

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A new styryl lactone, 5 R,6 R-5-hydroxy-6-styryltetrahydropyrane-2-one 2 was isolated from the roots of an endemic Goniothalamus lanceolatus Miq. of Sarawak, Malaysia. Furthermore, seven previously undescribed diastereomers, 5 R,6 R-5-hydroxygoniothalamin 3, 5 R,6 R-5-acetylgoniothalamin 4, 6 S,7 S,8 S-goniodiol-7-monoacetate 5, 6 S,7 S,8 S-goniodiol-8-monoacetate 6, goniofupyrone B 7, deoxygoniopypyrone B 8 and 1 S,5 S,7 R,8 S,3- endo,7- endo-(+)-8- epi-9-deoxygoniopypyrone acetate 9, along with six known styryl lactones (1, 10–15) were also isolated and characterized. 6 S-goniothalamin 1 is
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Tuchinda, Patoomratana, Bamroong Munyoo, Manat Pohmakotr, et al. "Cytotoxic Styryl-Lactones from the Leaves and Twigs ofPolyalthia crassa." Journal of Natural Products 69, no. 12 (2006): 1728–33. http://dx.doi.org/10.1021/np060323u.

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Shahzad Aslam, Muhammad, Muhammad Syarhabil Ahmad, Awang Soh Mamat, Muhammad Zamharir Ahmad, and Faridah Salam. "Goniothalamus: Phytochemical and Ethnobotanical Review." Recent Advances in Biology and Medicine 02 (2016): 34. http://dx.doi.org/10.18639/rabm.2016.02.292264.

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Goniothalamusspecies are used in widespread medicines for abortion, anti-aging, body pains, rheumatism, skin complaints, typhoid fever, tympanites, stomach ache and fever. The present study reviews the distribution of species along with their synonyms, their traditional usage, and correlated chemical compounds ofGoniothalamusspecies with stress on the authentication of their ethnobotanical uses. The findings in someGoniothalamusspecies suggest that the chemical nature of their derivatives, such as acetogenins and styryl-lactones, may justify the use of these species against cancer in Asian tra
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Popsavin, Velimir, Goran Benedeković, Bojana Srećo, et al. "Divergent Synthesis of Cytotoxic Styryl Lactones fromd-Xylose. The First Total Synthesis of (+)-Crassalactone C." Organic Letters 9, no. 21 (2007): 4235–38. http://dx.doi.org/10.1021/ol701734s.

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Popsavin, Velimir, Ivana Kovačević, Goran Benedeković, Mirjana Popsavin, Vesna Kojić, and Gordana Bogdanović. "Divergent Synthesis of Cytotoxic Styryl Lactones Related to Goniobutenolides A and B, and to Crassalactone D." Organic Letters 14, no. 23 (2012): 5956–59. http://dx.doi.org/10.1021/ol302860z.

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Popsavin, Velimir, Goran Benedeković, Bojana Srećo, et al. "Enantiodivergent synthesis of cytotoxic styryl lactones from d-xylose. The first total synthesis of (+)- and (−)-crassalactone C." Tetrahedron 65, no. 51 (2009): 10596–607. http://dx.doi.org/10.1016/j.tet.2009.10.079.

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Popsavin, Velimir, Goran Benedeković, Mirjana Popsavin, Vesna Kojić, and Gordana Bogdanović. "Divergent synthesis of cytotoxic styryl lactones isolated from Polyalthia crassa. The first total synthesis of crassalactone B." Tetrahedron Letters 51, no. 26 (2010): 3426–29. http://dx.doi.org/10.1016/j.tetlet.2010.04.114.

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Tantithanaporn, S., C. Wattanapiromsakul, A. Itharat, and N. Keawpradub. "Cytotoxic activity of acetogenins and styryl lactones isolated from Goniothalamus undulatus Ridl. root extracts against a lung cancer cell line (COR-L23)." Phytomedicine 18, no. 6 (2011): 486–90. http://dx.doi.org/10.1016/j.phymed.2010.10.010.

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Dissertations / Theses on the topic "Cytotoxic styryl lactones"

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Jovana, Francuz. "Nove izostere i bioizostere prirodnih stiril-laktona: dizajn, sinteza i antiproliferativna aktivnost." Phd thesis, Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, 2015. https://www.cris.uns.ac.rs/record.jsf?recordId=93661&source=NDLTD&language=en.

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U  radu  su  ostvarene  višefazne  sinteze  većeg  broja  analoga  prirodnih  stiril-laktona  (+)-goniofufurona  i  7-epi-(+)-goniofufurona  polazeći  iz  D-glukoze.Ispitana  je  in  vitro  citotoksičnost  sintetizovanih  analoga  prema  devetmalignih  i  jednoj  zdravoj  ćelijskoj  liniji.  Uspostavljeni  su  korelacioni  odnosiizmedju  strukture  i  antiproliferati vne  aktivnosti  sintetizovanih&n
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Ivana, Kovačević. "Prirodni stiril-laktoni, njihovi derivati i analozi kao potencijalni antitumorski agensi: Dizajn, sinteza i SAR ispitivanja." Phd thesis, Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, 2015. https://www.cris.uns.ac.rs/record.jsf?recordId=94214&source=NDLTD&language=en.

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U radu je ostvarena sinteza četiri prirodna proizvoda, goniobutenolida A i B,krasalaktona D i 3-deoksi-kardiobutanolida i 32 derivata i analoga polazeći izD-glukoze. Sinteza prirodnog stiril-laktona, kardiobutanolida&nbsp; i njegova 4derivata je izvedena polazeći iz&nbsp; D-ksiloze.&nbsp; Ispitan je uticaj sintetizovanihjedinjenja&nbsp; na inhibiciju rasta 10 tumorskih i jedne zdrave ćelijske linije.Uspostavljene su i&nbsp; korelacije izmedju strukture i antiproliferativne aktivnosti&nbsp;(SAR) i ispitan je mehanzam antitumorskog dejstva.<br>Synthesis of four natural products: goniobutenolide
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Goran, Benedeković. "Enantiodivergentna totalna sinteza odabranih stiril laktona i preliminarno ispitivanje njihove citotoksičnosti." Phd thesis, Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, 2012. http://dx.doi.org/10.2298/NS20121011BENEDEKOVIC.

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U radu je ostvarena enantiodivergentna totalna sinteza oba enantiomera goniofufurona, 7-epi-goniofufurona i krasalaktona C polazeći iz D-glukoze. Ključne faze u sintezi 7-epi-(+)-goniofufurona bile su stereoselektivna adicija fenilmagnezijum bromida na aldehidnu grupu pogodno za&scaron;tićene dialdoze, i stereospecifično formiranje furano-laktonskog prstena ciklokondenzacijom odabranog hemiacetalnog derivata sa Meldrum-ovom kiselinom. Sinteza (+)-goniofufurona i (+)-krasalaktona C zahtevala je inverziju konfiguracije na C-5u zajedničkom intermedijeru, koja je efikasno ostvarena u uslovima Mits
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