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1

Brown, Andrea J. Endogenous decay sustaining PCE degradation and associated stable isotope effects. National Library of Canada, 2000.

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2

Gadsden, Richard J. Measurement of caseload weightings associated with the Children Act. Home Office, 1994.

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3

I, Chung Victoria, Martinez Debbie, and Langley Research Center, eds. Transport delays associated with the NASA Langley flight simulation facility. National Aeronautics and Space Administration, Langley Research Center, 1995.

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4

1952-, Fidler John, ed. Stone building materials, construction and associated component systems: Their decay and treatment. Earthscan, 2006.

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5

Aho, Paul E. Decay losses associated with wounds in commercially thinned true fir stands in northern California. U.S. Dept. of Agriculture, Forest Service, Pacific Northwest Research Station, 1989.

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6

Yamamoto, Atsumasa. Decay of secondary flow and the associated loss variation downstream of an annular turbine stator cascade. National Aerospace Laboratory, 1989.

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7

Shaw, Colleen. Pictures vs words: The effects of imagery, concreteness, and delay on recall in a paired-associate learning task. Laurentian University, Department of Psychology, 1992.

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8

Finley, Mary Lou. Social and medical factors associated with diagnostic delay in breast cancer patients. 1986.

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9

Niccols, Alison, Karen Thomas, and Louis A. Schmidt. Socioemotional and Brain Development in Children with Genetic Syndromes Associated with Developmental Delay. Oxford University Press, 2011. http://dx.doi.org/10.1093/oxfordhb/9780195305012.013.0017.

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10

Fidler, John. Stone: Stone Building Materials, Construction and Associated Component Systems: Their Decay and Treatment (English Heritage Research Transactions). 2nd ed. Earthscan Publications Ltd., 2002.

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11

Ellam, Rob. 9. Uranium, thorium, and their daughters. Oxford University Press, 2016. http://dx.doi.org/10.1093/actrade/9780198723622.003.0009.

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All isotopes heavier than 208Pb (lead) are radioactive and many of these have half-lives that are long compared to the age of our Solar System. ‘Uranium, thorium, and their daughters’ describes the natural decay series where radioactive isotopes of uranium and thorium decay by α- and β-emission through several stages until a stable lead isotope is produced. The age of the Solar System and Earth has been established at 4.55 Ga through the isochron approach; U-Pb dating was also used to date the boundary between the Cretaceous and Palaeogene geological periods to 66 Ma, the period associated wit
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12

Dammeyer, Jesper. Mental Health and Psychosocial Well-Being in Deaf and Hard-of-Hearing Students. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190880545.003.0021.

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This chapter considers two main explanations for the high prevalence of mental disorders among children with congenital deafness. The first is a medical explanation and focuses on the possibility of shared biologic causes for the hearing loss and the associated mental disorders. The second is multifactorial and focuses on interrelated psychological and social factors, in particular the psychosocial impact of a child’s delay in learning language. According to this account, hearing loss risks language delay, which in turn risks delays in social and cognitive development, which in turn increases
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13

Oladeji, Bibilola D., and Kevin R. Robertson. Neuropsychological Evaluation for Persons with HIV and AIDS. Edited by Mary Ann Cohen, Jack M. Gorman, Jeffrey M. Jacobson, Paul Volberding, and Scott Letendre. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199392742.003.0012.

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With recent developments in the classification and definitions for HIV-associated neurocognitive disorders (HAND), neuropsychological assessments have become central to the diagnostic process. The pattern and manifestation of neurocognitive dysfunction associated with HIV have changed since the introduction of effective antiretroviral medications and their increasingly widespread use. Prior to the introduction of antiretroviral therapy, severe cognitive disorder presenting as HIV-associated dementia (HAD) was a common manifestation of HIV-associated neurocognitive disorders. In more recent tim
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14

Murphy, Elaine. Tyrosinemia Type II. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199972135.003.0014.

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Tyrosinemia type II is a rare oculocutaneous disorder that in some individuals is also associated with developmental delay or other neurological problems. Bilateral keratitis and painful hyperkeratotic lesions of the palms and soles are the typical presenting lesions. Diagnosis is suggested by the clinical picture, elevated plasma tyrosine levels, and specific urinary metabolites. It is an autosomal recessive condition caused by mutations in the tyrosine aminotransferase (TAT) gene. Treatment is aimed at reducing plasma tyrosine levels and consists of a low-protein diet with age-appropriate am
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15

Geary, David C. The Classification and Cognitive Characteristics of Mathematical Disabilities in Children. Edited by Roi Cohen Kadosh and Ann Dowker. Oxford University Press, 2014. http://dx.doi.org/10.1093/oxfordhb/9780199642342.013.017.

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Children in the bottom quartile of mathematics achievement are at high risk for underemployment in adulthood. These children include the roughly 7% of students with a mathematical learning disability (MLD) and another 10% of students with persistent low achievement (LA) that is not attributable to intelligence. The poor mathematics achievement of children who compose groups of MLD and LA students appears to be related to one or several deficits; specifically, (1) a delay in the development and poor fidelity of the system for representing approximate magnitudes; (2) difficulty mapping Arabic nu
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16

Paylor, Richard, Alexia M. Thomas, Surabi Veeraragavan, and Corinne M. Spencer. Putting Into Perspective the Use of the Fmr1 Knockout Mouse as a Model for Autism Spectrum Disorder. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199744312.003.0007.

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Chapter 7 is concerned with the presence of autism spectrum disorder (ASD) in individuals with Fragile X Syndrome (FXS). It is estimated that 21–50% of individuals with FXS meet the criteria for autism or autism with pervasive developmental delay not otherwise specified. Importantly, recent findings indicate that approximately 2–6% of individuals with ASDs have a mutation in the FMR1 gene, making it one of the most significant single genes associated with the presence of ASD.
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17

Mathiesen, Amber, and Kali Roy. Common Indications. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190681098.003.0005.

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This chapter describes common reasons for referral to a perinatal genetic counselor including age-related risks, personal and family history, ultrasound anomalies, teratogen exposure, recurrent pregnancy loss, and preconception counseling. Maternal and paternal age-related pregnancy risks are described, such as aneuploidy, single-gene conditions, and autism. A referral for a personal and/or family history of various conditions including single-gene conditions, aneuploidy, multifactorial conditions, birth defects, intellectual disability, developmental delay, autism, and consanguinity is descri
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18

John, Dewar, and Irwin Oliver. 4 Project Risks. Oxford University Press, 2015. http://dx.doi.org/10.1093/law/9780198715559.003.0005.

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This chapter considersthe identification, assessment, allocation, negotiation, and management of the risks associated with a particular project(such as delay risk, cost overruns, technology risk, off-take risk, revenue risk, operating risk, supply risk, currency risk, political risk and environmental and social risk). A project’s value is based principally on its ability to generate revenue during its operating phase. Both the sponsors and the lenders need to be able to effectively identify and manage the risks associated with that project. This chapter also identifies how those risks can be m
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19

Dodds, Chris, Chandra M. Kumar, and Frédérique Servin. Day-case anaesthesia in the elderly. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198735571.003.0005.

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Successful outcome from day surgery depends on good preoperative preparation, education of patients, day-surgery pathways, informed decisions regarding planned procedures, and postoperative care. Day surgery is widely accepted as the default position for the vast majority of patients requiring surgery, with inpatient stay chosen only by exclusion. Day surgery remains a good choice in the elderly, subject to appropriate home care after surgery. Patients should be assessed sufficiently ahead of the surgery to allow preparation, management of associated chronic diseases, and optimization. General
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20

Maxwell, Catherine. Carnal Flowers, Charnel Flowers. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198701750.003.0006.

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This chapter focuses on a single flower scent—the tuberose—strongly associated with the fragrance of Victorian decadence. Contrasting with the more delicate scent of the violet explored in Chapter 2 is the powerful perfume of the tuberose, an exotic hothouse flower, its fragrance evoking the body and decay. Starting with Shelley, this chapter tracks this heady fragrance through a range of texts to concentrate on three poems by late Victorian minor poets—Mark André Raffalovich, Mary Robinson, and Theodore Wratislaw—and shows how the scent of the tuberose is bound up with dangerous or voluptuous
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21

Nita, Dragos A., Miguel A. Cortez, Jose Luis Perez Velazquez, and O. Carter Snead. Biological Bases of Symptomatic Generalized Epilepsies in Children. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0040.

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Symptomatic generalized epilepsies represent a group of challenging epilepsy syndromes, most often seen in children, which share the hallmark of a triad encompassing multiple seizure types, electroencephalographical (EEG) evidence of diffuse brain involvement, and dysfunction in the intellectual domain (global developmental delay or mental retardation). SGEs include the early myoclonic encephalopathy, early infantile epileptic encephalopathy (Ohtahara syndrome), West syndrome, epilepsy with myoclonic-astatic seizures, epilepsy with myoclonic absence, Lennox-Gastaut syndrome, and the progressiv
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22

Anitescu, Magdalena, and David Arnolds. Spontaneous Intracranial Hypotension. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190271787.003.0005.

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Spontaneous intracranial hypotension is a condition that affects young and middle-aged individuals. Women are more frequently affected than men. It is associated with severe positional headache without previous dural puncture and is often confused with other common headache conditions. Delay in diagnosis of the condition may predispose patients to severe complications. Many radiodiagnostic tools carry important risks to patients, including nerve injury and iatrogenic spinal cord injury. Imaging studies must be correlated with a detailed medical history and a thorough physical examination. Epid
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23

Gatson, Na Tosha N., and Terri L. Woodard. Newlywed with Headache, Morning Sickness, and Subjective Right-side Weakness. Edited by Angela O’Neal. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190609917.003.0008.

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The chapter on infertility associated with cancer treatment examines key ethical issues in delivery of cancer care. Early signs and symptoms of a developing brain tumor are not always disturbing enough to alarm the patient to seek medical attention. Cause for delay in time-to-diagnosis is usually multifactorial, and unfortunately, risks worsening of the tumor condition. Initiation of treatment, however, must always be deferred until the patient has been informed of the risks and benefits of available therapies. This is especially true when the therapy could limit the patient’s fertility. Physi
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24

Chen, David K., and W. Curt LaFrance. Nonepileptic Events. Edited by Donald L. Schomer and Fernando H. Lopes da Silva. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190228484.003.0024.

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Nonepileptic events (NEE) represent important differential diagnoses in patients with neurobehavioral paroxysms, especially those with apparent drug-resistant epilepsy. Errant recognition of NEE may not only subject the patient to potential complications of unnecessary epilepsy treatment, but delay the delivery of treatment that properly addresses the underlying pathology. For many patients with NEE, such as those with the conversion disorder psychogenic nonepileptic seizures (PNES) or with physiologic NEE (e.g., cardiac-induced syncope), delays in the provision of proper treatment have been s
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25

Powell, Craig M. PTEN and Autism With Macrocepaly. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199744312.003.0010.

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Phosphatase and Tensin homolog deleted on chromosome 10 (PTEN) is a gene encoding an intracellular signaling molecule. PTEN was originally discovered as the gene responsible for a subset of familial hamartoma (tumor) syndromes associated with increased risk for certain cancers (Nelen et al., 1997) and as a gene often mutated in human cancers and tumor cell lines (Li et al., 1997; Steck et al., 1997). More recently, mutations in PTEN have been linked genetically to the clinical phenotype of autism or developmental delay with macrocephaly (Boccone et al., 2006; Butler et al., 2005; Buxbaum et al
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26

Spoletini, Giulia, and Nicholas S. Hill. Non-invasive positive-pressure ventilation. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0090.

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Non-invasive ventilation (NIV) has been increasingly used over the past decades to avoid endotracheal intubation (ETI) in critical care settings. In selected patients with acute respiratory failure, NIV improves the overall clinical status more rapidly than standard oxygen therapy, avoids ETI and its complications, reduces length of hospital stay, and improves survival. NIV is primarily indicated in respiratory failure due to acute exacerbations of chronic obstructive pulmonary disease, cardiogenic pulmonary oedema and associated with immunocompromised states. Weaker evidence supports its use
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27

Alyazidi, Raidan, and Soren Gantt. Herpes simplex Virus. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190604813.003.0007.

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Herpes simplex virus (HSV) types 1 and 2 cause several important syndromes, including congenital and perinatal infections that can cause devastating consequences in newborns (i.e., neonatal HSV). Most neonatal HSV infections are acquired intrapartum in the infected maternal birth canal. Since genital HSV infections are common, neonatal HSV is an important complication in infected women, even if maternal symptoms are absent. As a result of the developmental status of the fetal and newborn immune system, neonatal HSV infection is associated with life-threatening disease. This chapter reviews the
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28

Rees, Lesley. Growth and development. Edited by Norbert Lameire and Neil Turner. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0291.

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Enabling achievement of full height potential in a child with chronic kidney disease (CKD) is one of the major and most challenging goals for the paediatric nephrologist. Short stature is associated with psychological maladjustment and with increased morbidity and mortality. The causes of poor growth are multifactorial and include poor nutrition, and metabolic, haematological, and endocrine disturbances. The most vulnerable times are the periods of most rapid growth, that is, infancy and puberty. Growth during infancy is principally dependent on nutrition so many infants need supplemental ente
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29

Lunsford, Beverly, and Terry A. Mikovich. Interprofessional Team-Based Care. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190466268.003.0029.

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As older adults live longer, they experience a concomitant increase in chronic illness, which may be associated with a more frequent need for health care and intermittent or progressive functional decline. There is an increased need for regular health care monitoring as well as treatment and coordination of care among multiple providers and across settings to prevent, delay, or minimize decline in health and quality of life. Interprofessional collaboration is critical for safe coordination of care, reduction of duplication in services, and cost containment. Health care professionals who serve
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30

Kohn, Robert, Jessica Warner, Wendy Verhoek-Oftedahl, and Emily Murphy. Elder Abuse. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199374656.003.0021.

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There are five principal domains of elder abuse: physical abuse, psychological abuse, sexual abuse, neglect, and financial abuse. This chapter discusses the prevalence, prediction, and assessment of elder abuse as well as other factors related to abuse. The incidence of elder abuse is 24 times greater than the number of cases referred to social service, law enforcement, or other legal authorities. Caregiver factors, rather than risk factors associated with the abused elder, may be more important in predicting abuse. Lack of compliance with medical regimens, delay in seeking medical care, dispa
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31

Foggensteiner, Lukas, and Philip Beales. Bardet–Biedl syndrome and other ciliopathies. Edited by Neil Turner. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0314.

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Ciliopathies encompass a genotypically complex and phenotypically variable and overlapping series of disorders that makes the general term ‘ciliopathies’ very useful. The genes behind these conditions encode parts of the machinery of the primary cilium. This is also true of the major cystic kidney disorders autosomal dominant polycystic kidney disease and autosomal recessive polycystic kidney disease, but the ‘long tails’ of other ciliopathies are characterized by variable nephropathy (often without cyst formation), retinopathy, and effects on brain and skeletal development. Not all have subst
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32

Goffin, Eric, Laura Labriola, and Michel Jadoul. Bacterial and fungal infections in patients on peritoneal dialysis. Edited by Jonathan Himmelfarb. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0270.

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Infections specifically related to peritoneal dialysis include peritonitis on the one hand, and exit-site and tunnel infections on the other hand.The diagnosis of peritonitis rests on the classical triad of cloudy dialysate, abdominal pain, and presence of < 100 white-cells (including < 50 % polymorphonuclear cells) within the dialysate effluent. Because peritonitis is associated with high mortality and morbidity rates, empiric antibiotics should be initiated without delay, covering both Gram-positive and Gram-negative organisms. Most regimens include vancomycin or a first-generation cep
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33

Baildam, Eileen. Juvenile idiopathic arthritis. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0116.

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Juvenile idiopathic arthritis (JIA) is defined as arthritis lasting for 6 weeks or more presenting in childhood at any age up to 17 years. Arthritis is diagnosed clinically by the presence of joint pain, stiffness, and swelling with inflammation limiting the range of individual joint movement. There are subtypes that tend to follow distinct courses and with phenotypes that vary widely from a serious systemic inflammatory disorder of systemic JIA to single-joint monoarthritis. The differential diagnosis of JIA is wide and the best chance of long-term remission is where treatment is started as e
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34

Lambert, Heather. Urinary tract infection in infancy and childhood. Edited by Neil Sheerin. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0180_update_001.

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Urinary tract infection (UTI) in childhood is a common problem, which is frequently dismissed as trivial because most children with UTI have a good outcome. However, UTI is an important cause of acute illness in children and causes a considerable burden of ill health on children and families. In addition, UTI may be a marker of an underlying urinary tract abnormality. UTI in a few may cause significant long-term morbidity, renal scarring, hypertension, and renal impairment that may not present until adult life. Predicting which children will go on to have long-term sequelae remains a challenge
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35

Chilton, Adam, and Mila Versteeg. How Constitutional Rights Matter. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780190871451.001.0001.

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How Constitutional Rights Matter explores whether constitutionalizing rights improves respect for those rights in practice. Drawing on global statistical analyses, case studies in Colombia, Myanmar, Poland, Russia, and Tunisia, and survey experiments in Turkey and the United States, this book advances three claims. First, enshrining rights in constitutions does not automatically ensure that those rights will be respected in practice. For rights to matter, rights violations need to be politically costly, which can happen when citizens mobilize against governments that encroach upon their rights
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36

Whitworth, Caroline, and Stewart Fleming. Malignant hypertension. Edited by Neil Turner. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0216.

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Malignant hypertension (MH) is recognized clinically by elevated blood pressure together with retinal haemorrhages or exudates with or without papilloedema (grades III or IV hypertensive retinopathy); and may constitute a hypertensive emergency or crisis when complicated by evidence of end-organ damage including microangiopathic haemolysis, encephalopathy, left ventricular failure, and renal failure. Though reversible, it remains a significant cause of end-stage renal failure, and of cardiovascular and cerebrovascular morbidity and mortality in developing countries.MH can complicate pre-existi
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37

Lameire, Norbert, Raymond Vanholder, and Wim Van Biesen. Clinical approach to the patient with acute kidney injury. Edited by Norbert Lameire. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0222_update_001.

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The prognosis of acute kidney injury (AKI) depends on early diagnosis and therapy. A multitude of causes are classified according to their origin as prerenal, intrinsic (intrarenal), and post-renal.Prerenal AKI means a loss of renal function despite intact nephrons, for example, because of volume depletion and/or hypotension.There is a broad spectrum of intrinsic causes of AKI including acute tubular necrosis (ATN), interstitial nephritis, glomerulonephritis, and vasculitis. Evaluation includes careful review of the patient’s history, physical examination, urinalysis, selected urine chemistrie
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38

Tibaldi, Stefano, and Franco Molteni. Atmospheric Blocking in Observation and Models. Oxford University Press, 2018. http://dx.doi.org/10.1093/acrefore/9780190228620.013.611.

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The atmospheric circulation in the mid-latitudes of both hemispheres is usually dominated by westerly winds and by planetary-scale and shorter-scale synoptic waves, moving mostly from west to east. A remarkable and frequent exception to this “usual” behavior is atmospheric blocking. Blocking occurs when the usual zonal flow is hindered by the establishment of a large-amplitude, quasi-stationary, high-pressure meridional circulation structure which “blocks” the flow of the westerlies and the progression of the atmospheric waves and disturbances embedded in them. Such blocking structures can hav
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