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Dissertations / Theses on the topic 'Demenza frontotemporale'

Author: Grafiati
Published: 9 March 2023
Last updated: 31 July 2025

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1

VINCETI, GIULIA. "Personalità premorbosa nello spettro Demenza Frontotemporale – Sclerosi Laterale Amiotrofica (DFT-SLA): correlati comportamentali e di imaging cerebrale." Doctoral thesis, Università degli studi di Modena e Reggio Emilia, 2022. http://hdl.handle.net/11380/1273443.

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Background: la Demenza Frontotemporale (FTD) e la Sclerosi Laterale Amiotrofica (ALS) sono considerati due fenotipi dello stresso continuum neurodegenerativo (lo spettro FTD-ALS) caratterizzato da un substrato patologico e genetico comune. I pazienti possono presentare forme cliniche “pure”, cognitivo/comportamentali (FTD) o motorie (ALS), o forme miste (FTD-ALS). I fattori che determinano lo sviluppo di uno fenotipo piuttosto che un altro sono attualmente sconosciuti. Tuttavia, alcune caratteristiche della personalità dei pazienti sono percepite dai terapeuti come ricorrenti in entrambi i fen
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2

RIZ, M. A. DE. "FATTORI DI RISCHIO GENETICI NELLA MALATTIA DI ALZHEIMER E NELLA DEMENZA FRONTOTEMPORALE: STUDIO DI ASSOCIAZIONE DI GENI CANDIDATI POSIZIONALI E FUNZIONALI." Doctoral thesis, Università degli Studi di Milano, 2011. http://hdl.handle.net/2434/150554.

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Alzheimer’s disease (AD) and Frontotemporal Lobar Degeneration (FTLD) are two neurodegenerative and multifactorial diseases with complex etiology in which several genes involved in inflammation, oxidative damage and neuronal survival have been proposed to be candidate susceptibility factors. Given these premises, aims of this study have been to further analyze the association of candidate functional and positional genes in a population of 374 patient with AD, 291 with FTLD and 344 age matched controls. The first candidates studied have been the cell-dependent kinase inhibitor (CDKN) 2A and 2
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3

Haussmann, Robert, Marek Wysocki, Moritz D. Brandt, Andreas Hermann, and Markus Donix. "MAPT mutation associated with frontotemporal dementia and parkinsonism (FTDP-17)." Cambridge University Press, 2017. https://tud.qucosa.de/id/qucosa%3A70705.

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We present a 56-year-old patient suffering from frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17). The history included a three-generation pedigree and the patient was found to be a mutation carrier. The diagnosis was hindered by late appearance of the hypokinetic movement disorder. For clinicians, it is important to consider rare neurodegenerative disease variants in early-onset familial dementia syndromes with behavioral, cognitive, and motor symptoms
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4

Sampson, Elizabeth Lesley. "Longitudinal studies in frontotemporal dementia." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406422.

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5

Rascovsky, Katya. "Neuropsychological aspects of frontotemporal dementia /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2005. http://wwwlib.umi.com/cr/ucsd/fullcit?p3167837.

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6

Peters, Frédéric, Daniela Perani, Karl Herholz, et al. "Orbitofrontal Dysfunction Related to Both Apathy and Disinhibition in Frontotemporal Dementia." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-135825.

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Orbitofrontal metabolic impairment is characteristic of the frontal variant of frontotemporal dementia (fv-FTD), as are early changes in emotional and social conduct. Two main types of behavioral disturbances have been distinguished in fv-FTD patients: apathetic and disinhibited manifestations. In this study, we searched for relationships between brain metabolism and presence of apathetic or disinhibited behavior. Metabolic activity and behavioral data were collected in 41 fv-FTD patients from European PET centers. A conjunction analysis of the PET data showed an expected impairment of metabol
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7

Graham, A. J. "Learning and memory in frontotemporal dementia." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599590.

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8

Lindau, Maria. "Clinical differentiation between frontotemporal dementia and Alzheimer's disease : psychometric, behavioral, neuroimaging and neurophysiological information /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-430-5/.

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9

Vial, Eric. "La démence frontotemporale : analyse clinique de 14 observations." Montpellier 1, 2000. http://www.theses.fr/2000MON11173.

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10

Yancopoulou, Despina. "Neuropathological and genetic studies on frontotemporal dementia." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614974.

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11

Suárez, Calvet Marc. "Degeneració lobular frontotemporal: estudi clínic, neuropatològic i de biomarcadors." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/398996.

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La present tesi té com a objectiu estudiar des de diferents punts de vista la degeneració lobular frontotemporal (FTLD), una malaltia neurodegenerativa que es caracteritza per la pèrdua neuronal focal en els lòbuls frontals i temporals. Aquesta malaltia és molt heterogènia des del punt de vista clínic, neuropatològic i genètic, com també en els mecanismes patogènics. Aquesta heterogeneïtat fa que sovint el diagnòstic no sigui fàcil i que la seva classificació nosològica i la recerca en els seus mecanismes sigui especialment complexa. En aquesta tesi s’aborda aquesta heterogeneïtat estudiant di
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12

Peters, Frédéric, Daniela Perani, Karl Herholz, et al. "Orbitofrontal Dysfunction Related to Both Apathy and Disinhibition in Frontotemporal Dementia." Karger, 2006. https://tud.qucosa.de/id/qucosa%3A27680.

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Orbitofrontal metabolic impairment is characteristic of the frontal variant of frontotemporal dementia (fv-FTD), as are early changes in emotional and social conduct. Two main types of behavioral disturbances have been distinguished in fv-FTD patients: apathetic and disinhibited manifestations. In this study, we searched for relationships between brain metabolism and presence of apathetic or disinhibited behavior. Metabolic activity and behavioral data were collected in 41 fv-FTD patients from European PET centers. A conjunction analysis of the PET data showed an expected impairment of metabol
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13

Garcin, Béatrice. "Etude des bases neurales de la catégorisation chez les sujets sains et les patients cérébro-lésés." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066371/document.

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La catégorisation est un ensemble d’opérations mentales qui permettent de classer les objets et les évènements. C’est un processus crucial pour de nombreuses situations, telles que la survie dans le monde animal, l’apprentissage chez l’enfant, ou encore le raisonnement abstrait et la résolution de problèmes. Les patients ayant des lésions du cortex préfrontal présentent des difficultés pour les tâches de catégorisation, et l’existence de ces difficultés est corrélée au handicap fonctionnel de ces patients. Dans une première partie, nous avons mis au point une tâche de catégorisation adaptée po
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14

Petkov, Miroslav. "Familiäre Häufung und Apo E Genotyp bei frontotemporaler Demenz in einem ambulanten Kollektiv." kostenfrei, 2008. http://www.opus-bayern.de/uni-regensburg/volltexte/2009/1418/.

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15

Orr, Miranda Ethel. "Mouse and stem cell models of frontotemporal dementia." Diss., Montana State University, 2012. http://etd.lib.montana.edu/etd/2012/orr/OrrM0512.pdf.

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Alzheimer's disease (AD) is the most prevalent brain disease in the United States, and an escalating health concern. AD patient brains acquire hallmark protein aggregates, referred to as senile A beta plaques and neurofibrillary tangles (NFTs), that coincide with brain cell loss and dementia. A subset of AD patients carry mutant genes. Our understanding of AD largely relies on model systems that express these gene variants. Mice engineered to express AD-mutant human genes develop A beta plaques, but fail to develop the tau-containing NFTs or cell loss. Mutant tau variants are required to induc
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16

Rizzu, Patrizia. "Mutations in frontotemporal dementia linking tau to neurodegeneration." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2002. http://hdl.handle.net/1765/12093.

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17

Urwin, H. N. "Cellular models of CHMP2B mutations in frontotemporal dementia." Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/19564/.

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Mutations in the charged multivesicular body protein 2B gene (CHMP2B) cause frontotemporal dementia termed frontotemporal dementia linked to chromosome 3 (FTD-3) in a large Danish pedigree and also in an unrelated Belgian familial FTD patient. Genetic analyses on the Danish pedigree and the role of CHMP2B mutations in frontotemporal dementia are reported. The clinicopathological spectrum of FTD-3 and other FTD subtypes is also described. CHMP2B is a component of the endosomal sorting complex required for transport (ESCRT-III), which is required for formation and function of the multivesicular
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18

Suhonen, N. M. (Noora Maria). "Cognitive and behavioral characteristics of frontotemporal lobar degeneration." Doctoral thesis, Oulun yliopisto, 2017. http://urn.fi/urn:isbn:9789526216102.

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Abstract Frontotemporal lobar degeneration (FTLD) is the second commonest cause of dementia after Alzheimer’s disease (AD) in patients <65 years. Its most frequent clinical subtype is behavioral variant frontotemporal dementia (bvFTD) characterized by behavioral change and executive deficits. FTLD also encompasses two variants of primary progressive aphasia (PPA) characterized by language deficits. The majority of familial FTLD cases are linked to the C9ORF72 expansion mutation. As both cognitive and behavioral changes are core diagnostic features of FTLD, neuropsychological assessment is v
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19

Bradley, Paul. "The family experience of frontotemporal dementia : a qualitative study." Thesis, University of Birmingham, 2009. http://etheses.bham.ac.uk//id/eprint/403/.

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Overview This thesis is submitted in partial fulfilment for the requirements of the degree of Doctor of Clinical Psychology at the School of Psychology, University of Birmingham. It comprises of a research and a clinical volume. Volume I Volume I is the research component of the thesis. It consists of two papers, the first of which is a review of the literature that uses ‘Theory of Mind’ (ToM) tasks with people with frontal-variant frontotemporal dementia (fvFTD). All the research identified is systematically appraised in terms of the methodology and the quality of the published reports. The e
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20

Kipps, Christopher Myles William. "Insights into frontotemporal dementia : an imaging and neuropsychological study." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611105.

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21

Marshall, Charles R. "Physiology and neuroanatomy of emotional reactivity in frontotemporal dementia." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10053086/.

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The frontotemporal dementias (FTD) are a heterogeneous group of neurodegenerative diseases that cause variable profiles of fronto-insulo-temporal network disintegration. Loss of empathy and dysfunctional social interaction are a leading features of FTD and major determinants of care burden, but remain poorly understood and difficult to measure with conventional neuropsychological instruments. Building on a large body of work in the healthy brain showing that embodied responses are important components of emotional responses and empathy, I performed a series of experiments to examine the extent
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22

Ryan, Sarah. "Modelling C9orf72-linked frontotemporal dementia and amyotrophic lateral sclerosis." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/modelling-c9orf72linked-frontotemporal-dementia-and-amyotrophic-lateral-sclerosis(92740fce-3f4a-43cc-afed-b0f40f71ed03).html.

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Frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are neurodegenerative diseases with considerable clinical, genetic and pathological overlap. A GGGGCC hexanucleotide repeat expansion in a non-coding region of C9orf72 on chromosome 9 is the major cause of both FTLD and ALS. An understanding of the mechanisms through which the expansion leads to neurodegeneration will therefore be vital for development of novel therapeutics. There are 3 possible mechanisms through which the GGGGCC expansion may cause toxicity: (i) through haploinsufficiency of C9orf72, (ii) repeti
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23

Chassefeyre, Romain. "Rôle de CHMP2B et du complexe ESCRT-III dans le remodelage dans membranes cellulaires : cas des épines dendritiques." Thesis, Grenoble, 2013. http://www.theses.fr/2013GRENV049/document.

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CHMP2B est une sous-unité du complexe ESCRT-III, un complexe cytosolique très conservé, responsable du remodelage des membranes biologique, dans divers processus cellulaires. Des mutations de CHMP2B sont associées à une forme familiale de démence frontotemporale. Une étude précédente a mis en évidence que les mutants pathogènes de CHMP2B altèrent la morphologie des épines dendritiques, un phénomène potentiellement à l'origine de la maladie. Ce travail de recherche a pour objectif de décrire le rôle de CHMP2B, et du complexe ESCRT-III, dans la structure et le fonctionnement des épines dendritiq
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24

Dukart, Jürgen. "Contribution of FDG-PET and MRI to improve Understanding, Detection and Differentiation of Dementia." Doctoral thesis, Universitätsbibliothek Leipzig, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-66495.

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Progression and pattern of changes in different biomarkers of Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD) like [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) and magnetic resonance imaging (MRI) have been carefully investigated over the past decades. However, there have been substantially less studies investigating the potential of combining these imaging modalities to make use of multimodal information to further improve understanding, detection and differentiation of various dementia syndromes. Further the role of preprocessing has been rarely addres
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25

Rytty, R. (Riikka). "Resting-state functional MRI in behavioral variant of frontotemporal dementia." Doctoral thesis, Oulun yliopisto, 2016. http://urn.fi/urn:isbn:9789526211336.

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Abstract Frontotemporal lobar degeneration (FTLD) is the second most common neurodegenerative disease leading to early-onset dementia with an estimated worldwide prevalence of 10 to 30 cases per 100000 individuals in the age group of 46 to 65 years. Behavioral variant frontotemporal dementia (bvFTD) is the most common FTLD subtype. It is characterized by a progressive deterioration of behavior and personality as well as executive dysfunction. In Finland, almost 50 % of familial FTLD cases are attributable to the C9ORF72 mutation. bvFTD is associated with a characteristic pattern of brain atrop
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26

Ferrari, R. "Genetic analysis of frontotemporal dementia and progressive supra nuclear palsy." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1429248/.

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Genome-wide association study (GWAS) is an effective method for mapping genetic variants underlying common and complex diseases. This thesis describes the investigation of the disorders, frontotemporal dementia (FTD) and progressive supranuclear palsy (PSP). FTD affects the frontal/temporal lobes and presents behavioural changes (bvFTD), cognitive decline or language dysfunction (primary progressive aphasia [PPA]), whilst PSP affects predominantly the brain stem resulting in loss of balance, falls, and parkinsonian signatures. Beside recent advancements in the understanding of the clinical and
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27

Borger, Eva. "New intracellular mechanisms involved in Alzheimer's disease and frontotemporal dementia." Thesis, University of St Andrews, 2012. http://hdl.handle.net/10023/3092.

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Dementia causes an increasing social and economic burden worldwide, demanding action regarding its diagnosis, treatment and everyday management. Recent years have seen many advances in neurodegeneration research, but the search for new truly disease modifying therapies for Alzheimer's disease (AD) and frontotemporal dementia (FTD) has so far not been successful. This is mainly due to a lack of understanding of the precise intracellular events that lead up to neuronal dysfunction in early and in late stages of the disease. This thesis describes the approaches taken to extend the current knowled
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28

Long, Zhe. "Frontotemporal Dementia-Motor Neuron Disease: disease continuum or distinct entity?" Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/23012.

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Frontotemporal dementia-motor neuron disease (FTD-MND) is a rare disease characterised by the simultaneous occurrence of FTD and MND. Clinical, pathological, and genetic investigations have highlighted the association between FTD and MND, but much remains unclear. The experimental studies of this thesis comprehensively and systematically investigate the natural history of cognition and behaviour in FTD-MND and explore whether FTD-MND is distinct from well-recognised FTD phenotypes using clinical, neuropsychological and multimodal neuroimaging analyses. Results arising from two separate studies
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29

Chen, Yu. "Cerebellar contributions to cognitive changes in frontotemporal dementias." Thesis, The University of Sydney, 2020. https://hdl.handle.net/2123/21825.

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Mounting evidence indicates that the impact of cerebellar damage extends beyond motor function, and also affects cognition. Frontotemporal dementia (FTD) is associated with heterogeneous patterns of cortical atrophy, primarily affecting the frontal and/or temporal lobes. Previous research has also found cerebellar changes in FTD. The cognitive role of the cerebellum in FTD, however, remains unclear. This thesis, therefore, examines cerebellar contributions to cognitive changes using a combination of behavioural and neuroimaging approaches in the three main FTD subtypes, each with distinct clin
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30

Skoglund, Lena. "Molecular Mechanisms of Frontotemporal Lobar Degeneration." Doctoral thesis, Uppsala universitet, Institutionen för folkhälso- och vårdvetenskap, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9550.

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The aim of this thesis was to identify genetic factors involved in frontotemporal lobar degeneration (FTLD), a neurodegenerative disorder clinically characterised by a progressive change in personality, behaviour and language. FTLD is a genetically complex disorder and a positive family history is found in up to 40% of the cases. In 10-20% of the familial cases the disease can be explained by mutations in the gene encoding the microtubule associated protein tau (MAPT). In the first study we describe the clinical and neuropathological features of a Finnish family with FTLD caused by a mutation
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31

Silva, Thais Bento Lima da. "Validação da escala de estadiamento e progressão da demência frontotemporal (FTD-FRS)." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-09052018-111153/.

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Introdução: No Brasil há carência de instrumentos validados para a análise do curso da Demência Frontotemporal (DFT). Dessa forma, torna-se relevante a validação da Escala de Estadiamento e Progressão da Demência Frontotemporal (FTD-FRS). Em nosso meio, as escalas de estadiamento das demências, como a Clinical Dementia Rating (CDR), foram elaboradas para graduar a doença de Alzheimer (DA) e não incluem os sintomas específicos da DFT. Objetivos: 1. Realizar a tradução, adaptação transcultural e validação da FTD-FRS para o contexto brasileiro. 2. Avaliar a capacidade da FTD-FRS detectar alteraçõ
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32

Illán, Gala Ignacio. "Pathophysiological and structural underpinnings of frontotemporal lobar degeneration: a multimodal biomarker study." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/667265.

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La degeneración Lobular Frontotemporal (DLFT) es una constructo neuropatológico heterogéneo que incluye diferentes entidades neuropatológicas caracterizadas por una neurodegeneración prominente de los lóbulos frontales y temporales. A pesar de que algunos síndromes clínicos han demostrado predecir el diagnóstico neuropatológica de DLFT, la capacidad de los síndromes clínicos para predecir el diagnóstico neuropatológico es limitada. En esta tesis nos propusimos profundizar en los fundamentos fisiopatológicos y estructurales de la neurodegeneración relacionada con la DLFT mediante un estudio de
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33

Boutoleau-Bretonnière, Claire. "Comportement et dégénérescence frontotemporale : apport de la cohorte nantaise, développement de l'échelle DAPHNE et données neuropsychologiques." Thesis, Lyon 2, 2015. http://www.theses.fr/2015LYO20067/document.

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La dégénérescence frontotemporale est une pathologie rare, plaçant au premier plan les désordres comportementaux. Après analyse des troubles psycho-comportementaux et de leurs méthodes actuelles d’évaluation, nous avons élaboré et validé un nouvel outil, appelé DAPHNE (pour Desinhibition-Apathie-Persévérations-Hyeroralité-Négligence-Empathie) spécialement conçu pour dépister et quantifier la sévérité et la progression des troubles du comportement dans la variante frontale de dégénérescence frontotemporale (vfDFT), en pratique clinique courante. Cette validation a été effectuée de manière prosp
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34

Dols, Icardo Oriol 1987. "Assessing the genetic overlap in amyotrophic lateral sclerosis and frontotemporal dementia." Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/523545.

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There are overwhelming evidences that amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are part of a clinical, pathological and genetic continuum. The C9orf72 repeat expansion is the most common genetic defect among ALS/FTD patients. Besides, the use of next generation sequencing technologies has launched a new era in the study of human diseases. These approaches have unraveled an unprecedented amount of genes associated with both ALS and FTD. This work focuses on the study of the genetic overlap in the ALS/FTD spectrum. In this context, we have studied the C9orf72 expansi
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35

Rigg, Zoe M. "Exploring the emotional impact and adjustment in frontotemporal dementia family carers." Thesis, Canterbury Christ Church University, 2016. http://create.canterbury.ac.uk/15160/.

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Behavioural variant frontotemporal dementia (bv-FTD) is a rare form of the condition which manifests in personality and behavioural changes. Literature has indicated that this is a particularly challenging condition for family carers. Research has begun to explore the qualitative experiences of this group of carers, but is limited to date. The current study aimed to further explore these experiences with an emphasis on how these carers learn to adjust and accept their situation. Grounded theory methodology was adopted to analyse semi-structured interviews with 12 spousal carers (2 were male).
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36

Ingelson, Martin. "Molecular aspects of tau proteins in Alzheimer's disease and frontotemporal dementia /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4904-2/.

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37

Downey, L. E. "Defining the neuropsychological and neuroimaging phenotype of behavioural variant frontotemporal dementia." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1437738/.

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Frontotemporal dementia (FTD) is the second most common cause of early-onset dementia after Alzheimer’s disease (AD). There exists a paucity of quantifiable, sensitive, and specific biomarkers to detect this disease and track its manifestation and progression. The primary aim of this thesis was to develop and investigate new biomarkers for FTD, and focused on the examination of neuropsychological biomarkers in the behavioural variant of FTD (bvFTD) and their neuroanaotmical correlates. Chapters 4 and 5 explored social cognition in patients with FTD and the neural correlates of this behaviour.
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38

Mathieson, Danielle Ilene, and Danielle Ilene Mathieson. "Developing and Characterizing a TDP-43 Drosophila Model of Frontotemporal Dementia." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/625083.

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Frontotemporal Dementia (FTD) is a progressive neurodegenerative disease that is characterized by intraneuronal protein aggregates. In 45% of FTD cases, these intracellular inclusions contain TAR-DNA binding protein (TDP-43). Though many animal models of FTD exist, none have been generated in Drosophila melanogaster through TDP-43 overexpression that recapitulate learning and memory deficits found in late stages of the disease. In an attempt to develop such a model, we overexpressed TDP-43 and disease-associated mutant variants in the mushroom bodies of the fly. Their learning and memory
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39

Katzeff, Jared. "Understanding immune pathways altered in frontotemporal dementia and amyotrophic lateral sclerosis." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/25450.

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Frontotemporal dementia (FTD) is a neurodegenerative disease characterised by behaviour and language alterations. The major subtype is behavioural variant FTD (bvFTD). Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease characterised by muscle wasting. FTD and ALS are considered to be on the same disease spectrum, because of overlapping genetic, pathological and clinical traits. Increasing evidence suggests that neuroinflammation is a key aspect of both bvFTD and ALS pathogenesis. Currently, there are no definitive biomarkers for diagnosing either disease. Th
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40

O'Connor, Claire Marie. "Understanding behaviour and function in frontotemporal dementia: developing better intervention approaches." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/16899.

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Frontotemporal dementia (FTD) is the second most common younger onset dementia after Alzheimer’s disease, and comprises three primary clinical variants: behavioural variant (bvFTD), and two language variants divided according to the pattern of language deterioration: non-fluent primary progressive aphasia (nfvPPA) and semantic variant primary progressive aphasia (svPPA). FTD is associated with marked behavioural symptoms and impairments to everyday function in activities of daily living, which are both included as markers of disease progression in clinical and in research settings. Despite thi
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41

Kmetzsch, Virgilio. "Multimodal analysis of neuroimaging and transcriptomic data in genetic frontotemporal dementia." Electronic Thesis or Diss., Sorbonne université, 2022. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2022SORUS279.pdf.

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La démence frontotemporale (DFT) représente le deuxième type de démence le plus fréquent chez les adultes de moins de 65 ans. Il n’existe aucun traitement capable de guérir cette maladie. Dans ce contexte, il est essentiel d’identifier des biomarqueurs capables d’évaluer la progression de la maladie. Cette thèse a deux objectifs. Premièrement, analyser les profils d’expression des microARNs circulants prélevés dans le plasma sanguin de participants, afin d’identifier si l’expression de certains microARNs est corrélée au statut mutationnel et à la progression de la maladie. Deuxièmement, propos
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42

Lima-Silva, Thais Bento. "Funcionalidade e desempenho cognitivo na demência frontotemporal variante comportamental." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-25032013-164625/.

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Lima-Silva TB. Funcionalidade e desempenho cognitivo na demência frontotemporal variante comportamental. [Dissertação]. São Paulo: Faculdade de Medicina, Universidade de São Paulo, 2012. Resumo Introdução: Existem poucos estudos sobre alterações funcionais na Demência Frontotemporal variante comportamental (DFTvc). Subtipos de demência menos estudados, como a DFTvc, vêm ganhando destaque, por também apresentarem importância epidemiológica. Objetivou-se no presente estudo: 1. Caracterizar o desempenho funcional e cognitivo de pacientes com diagnóstico prévio de DFTvc, atendidos em ambulatórios
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43

Froelich, Fabre Susanne. "Genetic studies of frontotemporal dementia : with particular emphasis on the tau gene /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4714-7/.

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44

Heyanka, Daniel. "Lateralized and Overall Olfactory Identification Ability in Frontotemporal Dementia and Alzheimer's Disease." NSUWorks, 2010. http://nsuworks.nova.edu/cps_stuetd/38.

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This research involves an examination of the olfactory ability of individuals with Frontotemporal Dementia, Alzheimer's disease, and geriatric individuals with cognitive complaints owing to Major Depressive Disorder or Generalized Anxiety Disorder. The purpose of this study was to determine if olfactory differences were useful in differentiating between demented and non-demented individuals. Due to the pathway of the olfactory tract, it can be expected that there would be equal olfactory deficits in those diagnosed with Frontotemporal Dementia and Alzheimer's disease, and that these deficits w
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Roche, Lauren. "Frontotemporal dementia and primary progressive aphasia caregivers: coping, caregiving appraisals and wellbeing." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/13367.

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Frontotemporal Lobar Degeneration (FTLD) is a neurodegenerative disease with younger-onset, characterised by behavioural and/or language decline known as frontotemporal dementia (FTD) and primary progressive aphasia (PPA) respectively. Those caregiving for persons with FTD and PPA arguably appraise their caregiving role and adopt coping strategies unique to the syndrome. The aim of this thesis was to investigate the appraisals, coping strategies and psychological wellbeing of FTD/PPA caregivers. A systematic review (Study 1) found no caregiver or care-recipient characteristics were reliably p
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46

Liu, Lulu. "Temporal cognition: subjective time and its connection with memory in frontotemporal dementia." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/27780.

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Although ubiquitous and central to everyday life, how humans apprehend, experience, and mentally navigate time remains poorly understood. This thesis aimed to explore subjective time in healthy ageing, as well as pathological ageing, frontotemporal dementia (FTD), namely, behavioural-variant frontotemporal dementia (bvFTD), semantic dementia (SD) and progressive nonfluent aphasia (PNFA), to determine profiles and neural correlates of subjective time in older adults and dementia syndromes, and to reveal how subjective time alterations potentially relate to everyday memory impairments across syn
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Skibinski, Gaia. "Mutations in the ESCRTIII endosomal complex protein CHMP2B associate with frontotemporal dementia." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1446676/.

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Frontotemporal dementia (FTD) is a common cause of early onset progressive dementia. FTD is genetically heterogeneous with loci identified at several genomic regions including chromosome 17 and chromosome 9, An autosomal dominant form of FTD had previously been linked to the pericentromeric region of chromosome 3 (FTD3) in a large Danish family. The dementia starts with subtle personality and behaviour changes. The work presented in this thesis aimed to identify the mutant gene causing FTD3. Haplotype analysis was used to narrow the disease locus to between flanking markers, D3S3581 and D3S369
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48

Kaivorinne, A. L. (Anna-Lotta). "Frontotemporal lobar degeneration in Finland:molecular genetics and clinical aspects." Doctoral thesis, Oulun yliopisto, 2012. http://urn.fi/urn:isbn:9789526200132.

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Abstract Frontotemporal lobar degeneration (FTLD) is the second most common neurodegenerative disease leading to early-onset dementia (< 65 years), next to Alzheimer’s disease. FTLD is substantially a genetic disorder with up to 50% of cases having a positive family history. Mutations in the genes microtubule-associated protein tau (MAPT) and progranulin (PGRN) account for about 10–20% of all cases of FTLD. Hexanucleotide repeat expansion mutation within the gene C9ORF72 has recently been identified as the major cause of FTLD, FTLD with amyotrophic lateral sclerosis (ALS) and pure ALS
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Santos, Santos Miguel Ángel. "Clinicopathologic correlations and neuroimaging biomarkers in primary progressive aphasia." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/457508.

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Los trabajos incluidos en esta tesis van sobre el tema de la correlación clínico patológica en la enfermedad neurodegenerativa y más específicamente en la afasia primaria progresiva (APP). En el primer trabajo analizamos la proporción de positividad PET-amiloide en cada variante clínica para probar la hipótesis que clasificación según los criterios diagnósticos actuales (establecidos por consenso en 2011) de afasia primaria progresiva resultaría en grupos patológicamente homogéneos. Esta clasificación resulto ser altamente predictiva del estado del biomarcador de amiloide, en particular, la v
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Elfgren, Christina I. "Aspects of frontal and medial temporal brain functions neuropsychological and functional imaging studies in normals and in frontotemporal dementia /." Lund : Dept. of Psychology, University of Lund, and Dept. of Psychogeriatrics, University Hospital, 1997. http://books.google.com/books?id=EuZqAAAAMAAJ.

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