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Journal articles on the topic 'Derivatization'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Halket, John M., and Vladimir G. Zaikin. "Derivatization in Mass Spectrometry—5. Specific Derivatization of Monofunctional Compounds." European Journal of Mass Spectrometry 11, no. 1 (2005): 127–60. http://dx.doi.org/10.1255/ejms.712.

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The present paper is complementary to the foregoing reviews and describes some additional methods of the derivatization of particular functional groups mainly to enhance the structural information content of electron ionization and chemical ionization mass spectra. Derivatization approaches for the modification of unsaturated compounds, alcoholic, carboxylic, carbonyl, amine and other functional groups, are discussed. Derivatization for separation and quantitative determination of chiral enantiomeric compounds is also considered. Preliminary chemical and physical–chemical degradation for struc

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2

Sun, Hongbao, Qinghe Xue, Chang Zhang, Haoxing Wu, and Ping Feng. "Derivatization based on tetrazine scaffolds: synthesis of tetrazine derivatives and their biomedical applications." Organic Chemistry Frontiers 9, no. 2 (2022): 481–98. http://dx.doi.org/10.1039/d1qo01324f.

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The recent advances in tetrazine scaffold-based derivatizations have been summarized. The advantages and limitations of derivatization methods and applications of the developed tetrazine derivatives in bioorthogonal chemistry have been highlighted.

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3

Sevillano, R. M., G. Mortha, M. Barrelle, and D. Lachenal. "19F NMR Spectroscopy for the Quantitative Analysis of Carbonyl Groups in Lignins." Holzforschung 55, no. 3 (2001): 286–95. http://dx.doi.org/10.1515/hf.2001.048.

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Summary The amount of carbonyl groups in an organosolv lignin was determined by 19F NMR spectroscopy after different derivatizations: derivatization with trifluoromethylphenylhydrazine, fluorobenzoylation of alcohol groups formed after NaBH4 reduction of lignin, fluorobenzoylation of phenolic hydroxyl groups after catalytic hydrogenation of lignin. Oximation was also used for comparison. Carbonyl group contents determined by 19F NMR after trifluoromethylphenylhydrazine derivatization were in good correlation with results from other methods. Trifluoromethylphenylhydrazine derivatization is a fa

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4

Suska, Hubert, and Stanisław Popiel. "Optimization of Methods for Derivatization of Sarin, Soman, and VX Hydrolysis Products in the Process of Analyzing These Compounds Using Gas Chromatography." Bulletin of the Military University of Technology 73, no. 4 (2024): 47–56. https://doi.org/10.5604/01.3001.0055.1273.

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The identification and quantification of degradation products of organophosphorus chemical warfare agents (OP-CWAs)are critical for retrospective and forensic analysis or evidence proceedings. Due to their high polarity and low volatility, direct chromatographicanalysis of these hydrolysis products is often ineffective, necessitating derivatization to enhance analytical performance.This study focuses on optimizing the derivatization conditions of sarin, soman and VX hydrolysates – O–alkylmethylphosphonic acids(methylphosphonic (MPA), ethyl methylphosphonic (EMPA), isopropyl methylphosphonic (I

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5

SP., Karuppiah, and Anverbasha K. "Derivatization methodology in analytical separation." Journal of Indian Chemical Society Vol. 92, Apr 2015 (2015): 447–50. https://doi.org/10.5281/zenodo.5594449.

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Department of Chemistry, Sathyabama University, Chennai-600 117, India <em>E-mail </em>: Karu70123@rediffmail.com Derivatization is the transformation of one chemical compound into another with similar chemical structure. The chemical compounds specific functional group that involves in the derivatization reaction which transforms a educt to a derivate from boiling point, melting point, solubility, reactivity and chemical composition. This results in new chemical properties is used for separation and quantification. In HPLC there are two kinds of derivatization methods such as pre-column deriv

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6

Soma, Yuki, Yoshihiro Izumi, Takehiko Shimohira, et al. "In-Needle Pre-Column Derivatization for Amino Acid Quantification (iPDAQ) Using HPLC." Metabolites 12, no. 9 (2022): 807. http://dx.doi.org/10.3390/metabo12090807.

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Pre-column fluorescent derivatization has been used for the fast quantification of amino acids using high-performance liquid chromatography (HPLC) systems. However, it generally requires an offline in-vial derivatization process with multiple derivatization reagents. The offline derivatization requires the same number of reaction vials as the number of sample vials for use as a reaction chamber for the derivatization reaction in an autosampler. Therefore, the number of samples analyzed per batch using the pre-column derivatization method is halved. To benefit from the pre-column derivatization

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7

Bourgeois, Caroline, Nicolas Blanc, Jean-Claude Cannot, and Claire Demesmay. "Towards a Non-Biased Formaldehyde Quantification in Leather: New Derivatization Conditions before HPLC Analysis of 2,4-Dinitrophenylhydrazine Derivatives." Molecules 25, no. 23 (2020): 5765. http://dx.doi.org/10.3390/molecules25235765.

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In leathers, formaldehyde is currently analyzed according to EN ISO 17226-1 standard, by reversed phase liquid chromatography after off-line precolumn derivatization with 2,4 dinitrophenylhydrazine (DNPH) in strong acidic conditions. We first demonstrate that this standard is not adapted to leather retanned with resins likely to release formaldehyde by hydrolysis. Indeed, formaldehyde content may be largely overestimated due to concomitant resin hydrolysis (in harsh acidic conditions) that releases formaldehyde during the derivatization step and during the waiting time on autosampler before an

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8

Domergue, Jean-Baptiste, Julie Lalande, Cyril Abadie, and Guillaume Tcherkez. "Compound-Specific 14N/15N Analysis of Amino Acid Trimethylsilylated Derivatives from Plant Seed Proteins." International Journal of Molecular Sciences 23, no. 9 (2022): 4893. http://dx.doi.org/10.3390/ijms23094893.

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Isotopic analyses of plant samples are now of considerable importance for food certification and plant physiology. In fact, the natural nitrogen isotope composition (δ15N) is extremely useful to examine metabolic pathways of N nutrition involving isotope fractionations. However, δ15N analysis of amino acids is not straightforward and involves specific derivatization procedures to yield volatile derivatives that can be analysed by gas chromatography coupled to isotope ratio mass spectrometry (GC-C-IRMS). Derivatizations other than trimethylsilylation are commonly used since they are believed to

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9

Halket, John M., and Vladimir G. Zaikin. "Derivatization in Mass Spectrometry—7. On-Line Derivatization/Degradation." European Journal of Mass Spectrometry 12, no. 1 (2006): 1–13. http://dx.doi.org/10.1255/ejms.785.

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10

Orasche, J., J. Schnelle-Kreis, G. Abbaszade, and R. Zimmermann. "Technical Note: In-situ derivatization thermal desorption GC-TOFMS for direct analysis of particle-bound non-polar and polar organic species." Atmospheric Chemistry and Physics Discussions 11, no. 5 (2011): 15255–95. http://dx.doi.org/10.5194/acpd-11-15255-2011.

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Abstract. An in-situ derivatization thermal desorption method followed by gas chromatography and time-of-flight mass spectrometry (IDTD-GC-TOFMS) was developed for determination of polar organic compounds. Hydroxyl and carboxyl groups of compounds such as anhydrous sugars, alcohols and phenols, fatty acids and resin acids are targets of the derivatization procedure. Derivatization is based on silylation with N-Methyl-N-trimethylsilyl-trifluoroacetamide (MSTFA) during the step of thermal desorption. The high temperature of 300 °C during desorption is utilized for the in-situ derivatization on t

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11

Sanzheev, A. P., A. A. Mikhina, D. A. Sevko, et al. "Existing problems and ways of their solution in the analysis of amino acid composition." Proceedings of the Voronezh State University of Engineering Technologies 80, no. 4 (2019): 185–89. http://dx.doi.org/10.20914/2310-1202-2018-4-185-189.

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For obtain accurate aminoacids analysis results for peptide samples it is need to pay attention for method of analysis and method of sample preparation. Now some samplpreparation methods are known: acid and basic hydrolysis. In this article the comparison of two methods of aminoacids analysis were observed: pre-column or post-column derivatization. Analysis of lysine in lysine sulphate was studied, results were compared with control samples. For pre-column derivatization o-phthalic anhydride was used, and for post-column derivatization ninhydrin reagent was used. In experimental part advantage

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12

Djatmika, Rosalina, and Wang-Hsien Ding. "Optimization of Silylation for Parabens Determination by Gas Chromatography-Mass Spectrometry." ALCHEMY 5, no. 2 (2016): 55. http://dx.doi.org/10.18860/al.v5i2.3743.

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A low cost, environmental friendly and convenient method for parabens derivatization using Gas Chromatography-Mass Spectrometry (GC-MS) analysis is investigated. Derivatization is needed to enhance the thermal stability, detectability, and volatility of parabens to make them amenable for gas chromatographic analysis. This method involved on-line derivatization by silylating reagent: N-Methyl-N-tert-butyldimethylsilyltrifluoroacetamide (MTBSTFA), N,O-bis (trimethylsilyl) trifluoroacetamide (BSTFA), N-methyl-N-trimethylsilyltrifluoroacetamide (MSTFA), and N,O-bis(trimethylsilyl)acetamide (BSA).

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13

Nunes de Paiva, Maria José, Helvécio Costa Menezes, and Zenilda de Lourdes Cardeal. "Microwave-Assisted Derivatization of Bile Acids for Gas Chromatography/Mass Spectrometry Determination." ISRN Analytical Chemistry 2013 (September 5, 2013): 1–6. http://dx.doi.org/10.1155/2013/805678.

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Bile acids derived from cholesterol are produced in the liver, and their analysis is difficult due to their complex natures and their low concentrations in biological fluids. Mixtures of various derivatives, created via conventional heating, are used for such analyses. Microwave radiation is proposed to accelerate the derivatization process. This paper presents a mass fragmentation study and microwave-assisted derivatization (MAD) for the silylation of bile acids (cholic and ursodesoxycholic) prior to gas chromatography and mass spectrometry analysis. The derivatization was performed using the

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14

Orasche, J., J. Schnelle-Kreis, G. Abbaszade, and R. Zimmermann. "Technical Note: In-situ derivatization thermal desorption GC-TOFMS for direct analysis of particle-bound non-polar and polar organic species." Atmospheric Chemistry and Physics 11, no. 17 (2011): 8977–93. http://dx.doi.org/10.5194/acp-11-8977-2011.

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Abstract. An in-situ derivatization thermal desorption method followed by gas chromatography and time-of-flight mass spectrometry (IDTD-GC-TOFMS) was developed for determination of polar organic compounds together with non-polar compounds in one measurement. Hydroxyl and carboxyl groups of compounds such as anhydrous sugars, alcohols and phenols, fatty acids and resin acids are targets of the derivatization procedure. Derivatization is based on silylation with N-Methyl-N-trimethylsilyl-trifluoroacetamide (MSTFA) during the step of thermal desorption. The high temperature of 300 °C during desor

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15

Aydin, Senar, Mehmet Emin Aydin, Fatma Beduk, Arzu Tekinay, and Havva Kilic. "Analysis of diclofenac in water samples using in situ derivatization-vortex-assisted liquid-liquid microextraction with gas chromatography-mass spectrometry." Acta Pharmaceutica 68, no. 3 (2018): 313–24. http://dx.doi.org/10.2478/acph-2018-0024.

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Abstract A novel micro-extraction technique for a rapid and sensitive analysis of diclofenac (DCF) in water samples has been developed. DCF was derivatized and extracted simultaneously using vortex-assisted liquid-liquid micro-extraction (VALLME) prior to gas chromatography with mass spectrometry detection. The effects of extraction solvent volume, extraction and derivatization time and ionic strength of the sample were studied using 23 factorial experimental design. The optimum extraction conditions were as follows: 200 μL of chloroform, 25 μL of N-methyl-N-trimethylsilyl-trifluoroacetamide (

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16

Maliushevska, A. V., and L. A. Kartsova. "Comparative characteristics of different methods for electrophoretic determination of mono- and disaccarides using derivatization." Аналитика и контроль 28, no. 2 (2024): 98–107. http://dx.doi.org/10.15826/analitika.2024.28.2.003.

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The following variants of electrophoretic determination of sugars with prior derivatization are considered in the article: reductive amination using p-aminobenzoic acid ethyl ester (ABEE) and condensation with 1-phenyl-3-methyl-5-pyrazolone (PMP). Derivatization products were separated using capillary electrophoresis in both zone and micellar modes, and comparative estimate characteristics were obtained. The best efficiency (ca. 650 thousand theoretical plates), selectivity (2.1–2.4), and LOD (0.8–2.9 μg/mL) was observed for the separation of reductive amination products using micellar electro

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17

SHIBUKAWA, Masami, Kazunori SAITOH, Shingo OZAKI, and Hizuru NAKAJIMA. "Redox Derivatization Chromatography." BUNSEKI KAGAKU 62, no. 11 (2013): 985–1000. http://dx.doi.org/10.2116/bunsekikagaku.62.985.

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18

Garman, Elspeth, and James W. Murray. "Heavy-atom derivatization." Acta Crystallographica Section D Biological Crystallography 59, no. 11 (2003): 1903–13. http://dx.doi.org/10.1107/s0907444903012794.

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19

Wang, Yonghui, Ira S. Krull, Carrie Liu, and John D. Orr. "Derivatization of phospholipids." Journal of Chromatography B 793, no. 1 (2003): 3–14. http://dx.doi.org/10.1016/s1570-0232(03)00359-3.

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20

Gholson, Alexander R., Robert H. St Louis, and Herbert H. Hill. "Simultaneous Ultrasonic Extraction and Silylation for Determination of Organic Acids, Alcohol, and Phenols from Airborne Particulate Matter." Journal of AOAC INTERNATIONAL 70, no. 5 (1987): 897–902. http://dx.doi.org/10.1093/jaoac/70.5.897.

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Abstract Three methods for the extraction and derivatization of alcohols, carbox j lie acids, and phenols from airborne particulates were compared and evaluated. Derivatization of the sample during ultrasonic agitation to form trimethylsilyl derivatives increased the recovery of "reactive oxygenated hydrocarbons" compared to the standard method of extraction followed by derivatization. A single solvent, methylene chloride, with a strong and volatile silylating reagent, N,0- bis(trimethylsilyl)trifluoroacetamide, extracted a large number of reactive components with a minimum of interference. Wh

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21

Asif Iqbal, Mohammad, Jan E. Szulejko, and Ki-Hyun Kim. "Determination of methylamine, dimethylamine, and trimethylamine in air by high-performance liquid chromatography with derivatization using 9-fluorenylmethylchloroformate." Anal. Methods 6, no. 15 (2014): 5697–707. http://dx.doi.org/10.1039/c4ay00740a.

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22

Fonseca, Frederico, Ricardo Brito de Barros, Laura M. Ilharco, and Ana R. Garcia. "Spectroscopic Methods for Quantifying Gabapentin: Framing the Methods without Derivatization and Application to Different Pharmaceutical Formulations." Applied Spectroscopy 71, no. 11 (2017): 2519–31. http://dx.doi.org/10.1177/0003702817716181.

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This work aimed at analyzing the performance of direct spectroscopic methods for the quantification of gabapentin (GABAp), given the lack of previous studies, in comparison with the more reviewed and complex derivatization techniques, discussing their susceptibility to the pharmaceutical formulations. All of the methods analyzed showed high selectivity for this pharmaceutical analyte, with recoveries close to 100%. Absorption spectroscopy without derivatization yielded better sensitivity and lower limits of detection and quantification of gabapentin in aqueous solution (AqSol method) when comp

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23

Dogra, Raghav, and Uttam Kumar Mandal. "Recent Applications of Derivatization Techniques for Pharmaceutical and Bioanalytical Analysis through High-performance Liquid Chromatography." Current Analytical Chemistry 18, no. 2 (2022): 217–43. http://dx.doi.org/10.2174/1573411017666211108092115.

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Background: Derivatization of analytes is a quite convenient practice from an analytical perspective. Its vast prevalence is accounted by the availability of distinct reagents, primarily pragmatic for obtaining desired modifications in an analyte structure. Another reason for its handiness is typically to overcome limitations such as lack of sensitive methodology or instrumentation.The past decades have witnessed various new derivatization techniques including in-situ, enzymatic, ultrasound-assisted, microwave-assisted, and photochemical derivatization which have gain popularity recently. Meth

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Yuan, Chaoping, Wentao Shi, Peng Chen та ін. "Dissolution and transesterification of cellulose in γ-valerolactone promoted by ionic liquids". New Journal of Chemistry 43, № 1 (2019): 330–37. http://dx.doi.org/10.1039/c8nj03505a.

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Ionic liquids act as promoters for the dissolution of cellulose in GVL and also as catalysts for cellulose derivatization in GVL, providing a green and effective solvent system for cellulose processing and derivatization.

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25

JENNER, Andrew, Timothy G. ENGLAND, Okezie I. ARUOMA, and Barry HALLIWELL. "Measurement of oxidative DNA damage by gas chromatography–mass spectrometry: ethanethiol prevents artifactual generation of oxidized DNA bases." Biochemical Journal 331, no. 2 (1998): 365–69. http://dx.doi.org/10.1042/bj3310365.

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Analysis of oxidative damage to DNA bases by GC-MS enables identification of a range of base oxidation products, but requires a derivatization procedure. However, derivatization at high temperature in the presence of air can cause ‘artifactual ’ oxidation of some undamaged bases, leading to an overestimation of their oxidation products, including 8-hydroxyguanine. Therefore derivatization conditions that could minimize this problem were investigated. Decreasing derivatization temperature to 23 °C lowered levels of 8-hydroxyguanine, 8-hydroxyadenine, 5-hydroxycytosine and 5-(hydroxymethyl)uraci

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26

Luo, Yiqi Ruben, Cassandra Yun, and Kara L. Lynch. "Quantitation of Cannabinoids in Breath Samples Using a Novel Derivatization LC–MS/MS Assay with Ultra-High Sensitivity." Journal of Analytical Toxicology 43, no. 5 (2019): 331–39. http://dx.doi.org/10.1093/jat/bkz023.

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Abstract As the legalization of medical and recreational marijuana use expands, measurement of tetrahydrocannabinol (THC) in human breath has become an area of interest. The presence and concentration of cannabinoids in breath have been shown to correlate with recent marijuana use and may be correlated with impairment. Given the low concentration of THC in human breath, sensitive analytical methods are required to further evaluate its utility and window of detection. This paper describes a novel derivatization method based on an azo coupling reaction that significantly increases the ionization

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Laurynas, Jarukas, Kamarauskaitė Justina, Marksa Mindaugas, Trumbeckaitė Sonata, Banienė Rasa, and Ivanauskas Liudas. "Bio-based succinic acid sample preparation and derivatization procedure optimisation for gas chromatography-mass spectrometry analysis." ScienceRise: Pharmaceutical Science, no. 4(14) (August 31, 2018): 9–13. https://doi.org/10.15587/2519-4852.2018.135132.

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This study focused on bio-based succinic acid sample preparation and derivatization conditions optimization using GC-MS analytical method. Succinic acid, the precursor of a wide range bio-compounds, especially it is important in accumulation of mitochondrial metabolite succinate (citric acid cycle) and during ischemia controls reperfusion injury through mitochondrial reactive oxygen production. Accurate determination of analytes is the key in metabolomics to use as low molecular biomarkers in case to improve diagnostic methods. <strong>Methods. </strong>Gas chromatography-mass spectrometr

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Puiu, Diana, Alina Tatarus, Roxana Scutariu, Liliana Cruceru, and Toma Galaon. "PTV In Situ Derivatization of Several Acidic Herbicides Using a Newly Developed GC-MS/MS Method." Revista de Chimie 71, no. 1 (2020): 72–76. http://dx.doi.org/10.37358/rc.20.1.7814.

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The uses of herbicides increased during the last decades. Because acid herbicides can be identified in environmental samples, specific analytical methods are required. In this work a new GC-MS/MS method was developed in order to detect some pyridinecarboxylic acids (clopyralid, triclopyr and fluroxypyr) and a methoxybenzoic acid (dicamba) from environmental water samples. Because these polar analytes involve a derivatization step, a Programmed Temperature Vaporizing injector (PTV) was used to shape the derivatization conditions and to minimize the working time. This process is called in port d

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29

Wang, Yue, Jing Feng, Song Wu, et al. "Determination of Methyl Methanesulfonate and Ethyl Methylsulfonate in New Drug for the Treatment of Fatty Liver Using Derivatization Followed by High-Performance Liquid Chromatography with Ultraviolet Detection." Molecules 27, no. 6 (2022): 1950. http://dx.doi.org/10.3390/molecules27061950.

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A new derivatization high-performance liquid chromatography method with ultraviolet detection was developed and validated for the quantitative analysis of methanesulfonate genotoxic impurities in an innovative drug for the treatment of non-alcoholic fatty liver disease. In this study, sodium dibenzyldithiocarbamate was used as a derivatization reagent for the first time to enhance the sensitivity of the analysis, and NaOH aqueous solution was chosen as a pH regulator to avoid the interference of the drug matrix. Several key experimental parameters of the derivatization reaction were investigat

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Zorina, Maria, Victor V. Dotsenko, Pavel N. Nesterenko, et al. "Phthalylglycyl Chloride as a Derivatization Agent for UHPLC-MS/MS Determination of Adrenaline, Dopamine and Octopamine in Urine." Molecules 28, no. 7 (2023): 2900. http://dx.doi.org/10.3390/molecules28072900.

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Dopamine, adrenaline and octopamine are small polar molecules that play a vital role in regulatory systems. In this paper, phthalylglycyl chloride was proposed as a derivatization agent for octopamine, adrenaline and dopamine determination in urine for the first time. The derivatization procedure facilitated the use of reversed-phase liquid chromatography with positive electrospray ionization–high-resolution mass spectrometry. An LC-HRMS method was developed that provided quantification limits of 5 ng/mL and detection limits of 1.5 ng/mL for all analytes. The 95–97% yield of derivates was obse

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Baskal, Svetlana, Alexander Bollenbach, and Dimitrios Tsikas. "GC-MS Discrimination of Citrulline from Ornithine and Homocitrulline from Lysine by Chemical Derivatization: Evidence of Formation of N5-Carboxy-ornithine and N6-Carboxy-lysine." Molecules 26, no. 8 (2021): 2301. http://dx.doi.org/10.3390/molecules26082301.

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Derivatization of amino acids by 2 M HCl/CH3OH (60 min, 80 °C) followed by derivatization of the intermediate methyl esters with pentafluoropropionic anhydride (PFPA) in ethyl acetate (30 min, 65 °C) is a useful two-step derivatization procedure (procedure A) for their quantitative measurement in biological samples by gas chromatography-mass spectrometry (GC-MS) as methyl ester pentafluoropropionic (PFP) derivatives, (Me)m-(PFP)n. This procedure allows in situ preparation of trideutero-methyl esters PFP derivatives, (d3Me)m-(PFP)n, from synthetic amino acids and 2 M HCl/CD3OD for use as intern

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Li, Zhen, and Hongwei Sun. "Cost-Effective Detection of Perfluoroalkyl Carboxylic Acids with Gas Chromatography: Optimization of Derivatization Approaches and Method Validation." International Journal of Environmental Research and Public Health 17, no. 1 (2019): 100. http://dx.doi.org/10.3390/ijerph17010100.

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The reliable quantification of perfluoroalkyl carboxylic acids (PFCAs) in environmental samples like surface water by using gas chromatography (GC) remains challenging because the polar PFCAs call for derivatization before injection and problems involving the integration of sample pretreatment and derivatization procedures. Here we proposed a cost-effective method for the GC based determination of C4–C12 PFCAs in surface water samples by integrating solid phase extraction and PFCAs anilide derivatization. First, we assessed the performance of different PFCAs derivatization methods, namely este

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Xiao, Cenjun, Jing Xiao, Yuan Wu, et al. "Determination of Amino Acids of Novel Food in Food by HPLC Coupled with Pre-Column Derivatization." Foods 13, no. 24 (2024): 4012. https://doi.org/10.3390/foods13244012.

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A method for simultaneous determination of Theanine and γ-aminobutyric acid (GABA), as the novel food of amino acids, which was established using pre-column derivatization and high-performance liquid chromatography (HPLC). 4-Dimethylaminoazobe nzene-4′-sulfonyl chloride (DABS-Cl) is employed as the derivatization reagent with chromophore linked to Theanine and GABA, which lacks chromophore for DAD analysis in its pristine structure. After the detection wavelength was confirmed, the chromatographic and derivatization conditions were also optimized, including the chromatographic column, mobile p

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34

Gries, Paul, Atul Singh Rathore, Xiyuan Lu, et al. "Automated Trimethyl Sulfonium Hydroxide Derivatization Method for High-Throughput Fatty Acid Profiling by Gas Chromatography–Mass Spectrometry." Molecules 26, no. 20 (2021): 6246. http://dx.doi.org/10.3390/molecules26206246.

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Fatty acid profiling on gas chromatography–mass spectrometry (GC–MS) platforms is typically performed offline by manually derivatizing and analyzing small batches of samples. A GC–MS system with a fully integrated robotic autosampler can significantly improve sample handling, standardize data collection, and reduce the total hands-on time required for sample analysis. In this study, we report an optimized high-throughput GC–MS-based methodology that utilizes trimethyl sulfonium hydroxide (TMSH) as a derivatization reagent to convert fatty acids into fatty acid methyl esters. An automated onlin

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35

Bajpai, Vivek K., Na-Hyung Kim, and Kangmin Kim. "Chemical derivatization of pharmaceutical samples prior to Gas-Chromatography and Mass-Spectrometry analysis." Bangladesh Journal of Pharmacology 11, no. 4 (2016): 852. http://dx.doi.org/10.3329/bjp.v11i4.28588.

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<p>Derivatization is the process by which a compound is chemically changed, that has properties more amenable to a particular analytical method. Some samples analyzed by Gas-chromatography and Mass-spectrometry (GC-MS) require derivatization in order to make them suitable for analysis. Especially the compounds that have poor volatility, poor thermal stability, or that can be adsorbed in the injector will exhibit non-reproducible peak areas, heights, and shapes. Hence, this study focused on step-by-step visual demonstration of chemical derivatization of pharmaceutical samples prior to GC-

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Junnotula, Venkatraman, Barry R. Jones, Shelby Gorman, Miaoqing Shen, and Daniel Mulvana. "LC–MS/MS quantification of asymmetric dimethyl arginine and symmetric dimethyl arginine in plasma using surrogate matrix and derivatization with fluorescamine." Bioanalysis 12, no. 22 (2020): 1607–19. http://dx.doi.org/10.4155/bio-2020-0223.

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Aim: A novel LC–MS/MS method using a surrogate matrix and derivatization with fluorescamine was developed and validated for simultaneous quantification of asymmetric dimethyl arginine and symmetric dimethyl arginine. Methods & results: Asymmetric dimethyl arginine, symmetric dimethyl arginine and corresponding internal standards were extracted using protein precipitation and derivatization with fluorescamine followed by SPE. Derivatives were analyzed by turbo ion spray LC–MS/MS in the positive ion mode. Methodology was successfully transferred across multiple preclinical species and utiliz

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37

Susinskis, Igors, Peteris Mekss, and Juris Hmelnickis. "Method development for the determination of 1,1-dimethylhydrazine by the high-performance liquid chromatography–mass spectrometry technique." European Journal of Mass Spectrometry 24, no. 4 (2018): 352–59. http://dx.doi.org/10.1177/1469066718761437.

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Unsymmetrical dimethyl hydrazine is highly toxic, carcinogenic compound, widely used for organic synthesis and drug development. Therefore, due to its high reactivity, direct analysis is problematic. Current study proposes to use derivatization reaction to increase selectivity and sensitivity of high-performance liquid chromatography–mass spectrometry method. Different derivatization agents were tested and optimal reaction media was found. Derivatization was performed by using small amounts of reagents to lower the cost of analysis. The full validation of the method was performed and it can be

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38

Perez, Hermes Licea, and Christopher A. Evans. "Chemical derivatization in bioanalysis." Bioanalysis 7, no. 19 (2015): 2435–37. http://dx.doi.org/10.4155/bio.15.182.

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Priefer, Ronny, Eric Martineau, and David N. Harpp. "Derivatization of dicubyl disulfide." Journal of Sulfur Chemistry 28, no. 6 (2007): 529–35. http://dx.doi.org/10.1080/17415990701684701.

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Hünemörder, Paul, and Esteban Mejía. "Photocatalyzed allylic derivatization reactions." Catalysis Science & Technology 10, no. 20 (2020): 6754–68. http://dx.doi.org/10.1039/d0cy01377c.

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Catalytic allylation reactions are important methodologies to produce fine chemicals and synthetic building blocks. This review discloses state-of-the-art photocatalyzed allylation methodologies, their reaction mechanisms, and synthetic applications.

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Stalikas, Constantine D., and Yiannis C. Fiamegos. "Microextraction combined with derivatization." TrAC Trends in Analytical Chemistry 27, no. 6 (2008): 533–42. http://dx.doi.org/10.1016/j.trac.2008.04.005.

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Bardelmeijer, H. A., H. Lingeman, C. de Ruiter, and W. J. M. Underberg. "Derivatization in capillary electrophoresis." Journal of Chromatography A 807, no. 1 (1998): 3–26. http://dx.doi.org/10.1016/s0021-9673(98)00230-1.

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MITAMURA, Kuniko, and Kazutake SHIMADA. "Derivatization in LC/MS." YAKUGAKU ZASSHI 118, no. 6 (1998): 206–15. http://dx.doi.org/10.1248/yakushi1947.118.6_206.

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Fritsche-Guenther, Raphaela, Yoann Gloaguen, Anna Bauer, et al. "Optimized Workflow for On-Line Derivatization for Targeted Metabolomics Approach by Gas Chromatography-Mass Spectrometry." Metabolites 11, no. 12 (2021): 888. http://dx.doi.org/10.3390/metabo11120888.

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Using manual derivatization in gas chromatography-mass spectrometry samples have varying equilibration times before analysis which increases technical variability and limits the number of potential samples analyzed. By contrast, automated derivatization methods can derivatize and inject each sample in an identical manner. We present a fully automated (on-line) derivatization method used for targeted analysis of different matrices. We describe method optimization and compare results from using off-line and on-line derivatization protocols, including the robustness and reproducibility of the met

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Amin, Lena Nawzad, Mohammed N. Sabir, and Emad Manhal Al-Khafaji. "Bioavailability Enhancement of Silybin Through Carbon-23 Acid Derivatization." Journal of Zankoy Sulaimani - Part A 17, no. 3 (2015): 87–96. http://dx.doi.org/10.17656/jzs.10403.

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G, Anusha, Venkatesh Prasad, and Nagaraj Gouda. "Determination of Saxagliptin Monohydrate by Derivatization UV-Vis Spectroscopy." International Journal of Science and Research (IJSR) 10, no. 11 (2021): 353–55. https://doi.org/10.21275/sr20610163533.

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Kawasue, Shimba, Kyoko Kuniyoshi, Masashi Uema, and Naomasa Oshiro. "Tetrodotoxin Derivatization with a Newly Designed Boron Reagent Leads to Conventional Reversed-Phase Liquid Chromatography." Toxins 16, no. 6 (2024): 260. http://dx.doi.org/10.3390/toxins16060260.

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Tetrodotoxin (TTX) is a representative natural toxin causing pufferfish food poisoning, which is especially prominent in East and Southeast Asia, including Japan. TTX has been analyzed through post-column derivatization high-performance liquid chromatography (HPLC), ion-pair LC-MS(/MS), and hydrophilic interaction liquid chromatography (HILIC)-MS(/MS) as alternatives to the mouse bioassay method. However, post-column derivatization requires a system for online derivatization reactions, and with the ion-pair LC-MS approach, it is difficult to remove residual ion-pair reagents remaining in the e

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Franzin, Martina, Rebecca Di Lenardo, Rachele Ruoso, and Riccardo Addobbati. "Incomplete Decarboxylation of Acidic Cannabinoids in GC-MS Leads to Underestimation of the Total Cannabinoid Content in Cannabis Oils Without Derivatization." Pharmaceutics 17, no. 3 (2025): 334. https://doi.org/10.3390/pharmaceutics17030334.

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Background: Cannabis oil titration consists of quantification of the acidic precursors tetrahydrocannabinolic acid (THCA) and cannabidiolic acid (CBDA) and their decarboxylated products, the active neutral cannabinoids delta-9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD), and is recommended to ensure galenic preparation quality through gas and liquid chromatography coupled with mass spectrometry (GC-MS; LC-MS). Analyses by LC-MS and GC-MS involving derivatization allow for detection of acidic and neutral cannabinoids; on the contrary, GC-MS without derivatization determines only neutral

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Mantzourani, Christiana, and Maroula G. Kokotou. "Liquid Chromatography-Mass Spectrometry (LC-MS) Derivatization-Based Methods for the Determination of Fatty Acids in Biological Samples." Molecules 27, no. 17 (2022): 5717. http://dx.doi.org/10.3390/molecules27175717.

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Fatty acids (FAs) play pleiotropic roles in living organisms, acting as signaling molecules and gene regulators. They are present in plants and foods and may affect human health by food ingestion. As a consequence, analytical methods for their determination in biological fluids, plants and foods have attracted high interest. Undoubtedly, mass spectrometry (MS) has become an indispensable technique for the analysis of FAs. Due to the inherent poor ionization efficiency of FAs, their chemical derivatization prior to analysis is often employed. Usually, the derivatization of the FA carboxyl group

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Inoue, Makoto, Jiro Akimaru, Toyohiro Nishikawa, Noriaki Seki, and Hidenori Yamada. "A new derivatizing agent, trimethylammoniopropyl methanethiosulphonate, is efficient for preparation of recombinant brain‐derived neurotrophic factor from inclusion bodies." Biotechnology and Applied Biochemistry 28, no. 3 (1998): 207–13. http://dx.doi.org/10.1111/j.1470-8744.1998.tb00531.x.

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Derivatization with trimethylammoniopropyl methanethiosulphonate (TAPS‐sulphonate) enabled brain‐derived neurotrophic factor (BDNF) to be prepared efficiently from Escherichia coli inclusion bodies. Reduced BDNF obtained from inclusion bodies solubilized by urea and reduced by dithiothreitol was suggested to form a complex with itself or with other compounds such as lipids. It could hardly be adsorbed on to cation‐exchange resin for partial purification prior to a refolding reaction. Reversible derivatization of cysteine residues was tested as a method of dissociating BDNF from such complexes.

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