Log in

Relevant bibliographies by topics / Detoxification mechanisms / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Detoxification mechanisms.

Dissertations / Theses on the topic 'Detoxification mechanisms'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 34 dissertations / theses for your research on the topic 'Detoxification mechanisms.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Pillai, Jitesh Kannan. "Mechanisms of Arsenic Detoxification and Resistance." FIU Digital Commons, 2014. http://digitalcommons.fiu.edu/etd/1699.

Full text

Abstract:

Arsenic is a ubiquitous environmental toxic substance. As a consequence of continual exposure to arsenic, nearly every organism, from Escherichia coli to humans have evolved arsenic detoxification pathways. One of the pathways is extrusion of arsenic from inside the cells, thereby conferring resistance. The R773 arsRDABC operon in E. coli encodes an ArsAB efflux pump that confers resistance to arsenite. ArsA is the catalytic subunit of the pump, while ArsB forms the oxyanion conducting pathway. ArsD is an arsenite metallochaperone that binds arsenite and transfers it to ArsA. The interaction o

APA, Harvard, Vancouver, ISO, and other styles

2

Hamel, Robert D. "Aluminum detoxification mechanisms in Pseudomonas fluorescens." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0025/MQ31433.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Choudhury, Hassanul Ghani. "Structural and functional studies of bacterial detoxification mechanisms." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/39387.

Full text

Abstract:

Bacterial multidrug resistance is a prominent issue with an ever-increasing amount of drugs becoming ineffective in treating bacterial infections. The elucidation of the 3D structure of bacterial resistance proteins has become extremely important in the development of new antimicrobials. Bacteria can sense external stimuli and regulate the expression of genes that can confer antibiotic resistance. Response regulators are capable of binding DNA both in their phosphorylated and unphosphorylated states, upregulating gene expression. The crystal structure of the unphosphorylated dimeric Escherichi

APA, Harvard, Vancouver, ISO, and other styles

4

Butko, Emerald Claire. "Molecular mechanisms of cadmium detoxification and long distance transport in plants." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p1452831.

Full text

Abstract:

Thesis (M.S.)--University of California, San Diego, 2008.<br>Title from first page of PDF file (viewed June 16, 2008). Available via ProQuest Digital Dissertations. Includes bibliographical references.

APA, Harvard, Vancouver, ISO, and other styles

5

Van, Egmond Roger Albert. "The effects of organic pollution on fish detoxification mechanisms and reproduction." Thesis, Edinburgh Napier University, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386002.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Arkenberg, Anke. "Mechanisms of anaerobic nitric oxide detoxification by Salmonella enterica serovar Typhimurium." Thesis, University of East Anglia, 2013. https://ueaeprints.uea.ac.uk/48768/.

Full text

Abstract:

Salmonella is the cause of millions of food- and water-borne infections worldwide. Systemic infection and gastroenteritis are the main diseases and often prove fatal to immunocompromised patients. Key to Salmonella’s pathogenicity is the survival of several components of the innate immune system encountered during infection. Reactive oxygen and nitrogen species (ROS and RNS) are an integral part of this antibacterial defence of the immune system. Exposure to ROS and RNS occurs within phagocytic immune cells such as macrophages, where such generation of radicals is used to combat pathogens. NO

APA, Harvard, Vancouver, ISO, and other styles

7

Pantoja, Munoz Leonardo. "The mechanisms of arsenic detoxification by the green microalgae chlorella vulgaris." Thesis, Middlesex University, 2014. http://eprints.mdx.ac.uk/13252/.

Full text

Abstract:

The mechanisms of arsenic interaction with the green microalga Chlorella vulgaris (C. vulgaris) and the potential for its bio-remediation from water were investigated. This was made possible by the development of an improved arsenic extraction from C. vulgaris, leading to successful glutathione and phytochelatins (GSH/PC) complex speciation analysis with 71.1% efficiency. The response of C. vulgaris when challenged by As(III), As(V) and dimethylarsinic acid (DMA) was assessed through experiments on adsorption, efflux and speciation of arsenic (reduction, oxidation, methylation and chelation wi

APA, Harvard, Vancouver, ISO, and other styles

8

FERRARI, MARCO. "INVESTIGATIONS ON THE DETOXIFICATION MECHANISMS OF THE MALARIA VECTOR ANOPHELES STEPHENSI." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/563070.

Full text

Abstract:

Il lavoro di tesi si è focalizzato sulla risposta del defensoma ad uno stimolo chimico in Anopheles stephensi, il principale vettore malarico nel sud dell’Asia. La malaria è una malattia parassitaria che ha come agenti eziologici parassiti appartenente al genere Plasmodio, di cui cinque specie sono note per essere responsabili per la malattia nell’uomo. Secondo l’Organizzazione Mondiale della Sanità (World Health Organization, WHO) la malaria ha causato nel 2016 circa 445.000 morti e 216 milioni di casi, rappresentando una minaccia alla salute delle popolazioni che vivono in zone endemiche ed

APA, Harvard, Vancouver, ISO, and other styles

9

Santini, Olivier. "Effects of copper on calcium metabolism and detoxification mechanisms in freshwater bivalve species of "Anodonta." Thesis, Université de Lorraine, 2012. http://www.theses.fr/2012LORR0397/document.

Full text

Abstract:

Le Cuivre (Cu) appartient aux métaux majeurs contaminant les écosystèmes dulcicoles européens. Les bivalves sont des filtreurs qui bioaccumulent fortement les métaux lourds comme le Cu, lequel, en excès cause de graves troubles métaboliques, et physiologiques. Le but de cette thèse est d'étudier les mécanismes de toxicité et de détoxication du cuivre chez Anodonta cygnea et Anodonta anatina, bivalves largement répandus dans les eaux continentales. L'effet du Cu a d'abord été étudié sur le transport cellulaire du calcium (Ca). Le Ca intervient dans de nombreux processus biologiques et le métabo

APA, Harvard, Vancouver, ISO, and other styles

10

Singh, Satish Kumar. "Mechanisms of Bacterial Copper Detoxification and Oxygen Reduction in CueO and Chemotactic Signal Amplification by Receptor Clustering." Diss., The University of Arizona, 2009. http://hdl.handle.net/10150/194765.

Full text

Abstract:

CueO is a multicopper oxidase and catalyses the four-electron reduction of dioxygen to water and functions to protect Escherichia coli against copper-induced toxicity. The mechanism of oxygen reduction in multicopper oxidases has been well studied, but the key structures of the reaction intermediates are not known. A combination of kinetic measurements, mutagenesis and X-ray crystallographic studies were conducted to entrap and structurally characterize the reaction states in CueO. CueO has a methionine-rich insert and a labile copper binding site, two features found only in multicopper oxidas

APA, Harvard, Vancouver, ISO, and other styles

11

Machial, Cristina Maria. "Efficacy of plant essential oils and detoxification mechanisms in Choristoneura rosaceana, Trichoplusia ni, Dysaphis plantaginea and Myzus persicae." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/27244.

Full text

Abstract:

The obliquebanded leafroller, Choristoneura rosaceana, and the rosy apple aphid, Dysaphis plantaginea are serious pests in apple orchards throughout North America, while the green peach aphid, Myzus persicae and the cabbage looper, Trichoplusia ni are serious pests in vegetable greenhouses. In an effort to reduce the impact of these pests on their respective crops, growers typically resort to multiple insecticide applications per year for the control of each pest. However, concerns regarding the risk of such pesticides to human and environmental health have led to renewed calls for the devel

APA, Harvard, Vancouver, ISO, and other styles

12

McDowell, Rosemary Eleanor. "Analysis of aldehyde detoxification mechanisms and the effects of a novel aldehyde scavenging drug in experimental diabetic retinopathy." Thesis, Queen's University Belfast, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.680435.

Full text

Abstract:

Recent studies have identified that retinal Muller cells accumulate the acrolein (ACR)-derived protein adduct FDP-lyslne during diabetes. The phenomenon has been linked with the dysfunction of these calls in the early stages of diabetic retinopathy. The current project investigates the processes underlying the accumulation of FOP-lysine In Muller cells during diabetes, and strategies for preventing Its accumulation and related pathology. RT-PCR was used to Identify the enzymes capable of detoxifying ACR that were expressed In the rat retina. Immunohistochemistry (IHC) experiments Idenified tha

APA, Harvard, Vancouver, ISO, and other styles

13

Santini, Olivier [Verfasser], and Hartmut [Akademischer Betreuer] Frank. "Effects of copper on calcium metabolism and detoxification mechanisms in freshwater bivalve species of Anodonta / Olivier Santini. Betreuer: Hartmut Frank." Bayreuth : Universität Bayreuth, 2013. http://d-nb.info/1059353415/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Fang, Chong [Verfasser], and Thorsten [Akademischer Betreuer] Mascher. "Signal transduction mechanisms and wiring specificity of bce-type antimicrobial peptide sensing and detoxification modules in firmicutes / Chong Fang. Betreuer: Thorsten Mascher." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2015. http://d-nb.info/1077987005/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Gasperoni, Alessia. "Removal of inhibitors from birch pretreatment liquor by nanofiltration: Mechanisms of separation and influence of operational variables and mode." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/15147/.

Full text

Abstract:

Lignocellulosic biomass has attracted considerable attention as an alternative feedstock for the production of fuels, energy and chemicals, due to its renewability, abundance and reduced cost. Pretreatment and hydrolysation of lignocellulose releases sugars that are subsequently converted by fermentation. However, by-products such as aliphatic acids and furans could be generated during the upstream processes, which could inhibit enzymes and fermenting microorganisms. In addition, fermentation of low-concentrated sugars would lead to low products concentration and, consequently, to higher recov

APA, Harvard, Vancouver, ISO, and other styles

16

Cookson, Stephen. "Aluminium toxicity (with reference to copper) in the aqueous environment and the mechanisms of its glutathione-mediated detoxification in the brine shrimp (Artemia franciscana)." Thesis, University of Central Lancashire, 2001. http://clok.uclan.ac.uk/20914/.

Full text

Abstract:

Glutathione (y-glutamylcysteinylglycine) is a vital and ubiquitous component of biological systems that has been demonstrated to have a protective role against the toxicity of a wide array of xenobiotics and their metabolic by-products. It has been shown to detoxify many metals by direct and indirect mechanisms; but this is not the case with Al. Inputs of this metal into the environment have increased substantially since the industrial revolution, due to its use in industrial processes and the advent of acid rain. As such, it is crucial that the full implications of such exposure upon the envi

APA, Harvard, Vancouver, ISO, and other styles

17

Lawson, Kathryn René. "Catabolism as a mechanism of polyamine detoxification." Diss., The University of Arizona, 1998. http://hdl.handle.net/10150/288919.

Full text

Abstract:

Maintenance of optimal polyamine pool levels is critical for cell survival. Intracellular polyamine depletion is usually cytostatic, whereas unregulated polyamine accumulation can result in cytotoxicity. The purpose of this work was to examine the importance of polyamine depletion in cell survival, either through increased polyamine catabolism or decreased polyamine synthesis. The polyamine analogue CHENSpm, which induces apoptosis in several cell lines, was used to examine the role of polyamine catabolism in cell survival. The susceptibility of Chinese hamster ovary cells and HCT 116 human co

APA, Harvard, Vancouver, ISO, and other styles

18

Nascimento, Antonio Rogério Bezerra do. "Bases genéticas e moleculares da resistência de Spodoptera frugiperda (J.E. Smith, 1797) (Lepidoptera: Noctuidae) a lufenuron." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/11/11146/tde-04022014-095258/.

Full text

Abstract:

As bases genéticas e moleculares da resistência de Spodoptera frugiperda (J.E. Smith) a lufenuron foram exploradas no presente estudo. Inicialmente, uma linhagem de S. frugiperda resistente a lufenuron foi selecionada a partir de uma população coletada na cultura do milho na região de Montevidiu-GO com intenso uso desse inseticida. As curvas de concentração-resposta a lufenuron para as linhagens de S. frugiperda suscetível (SUS) e resistente (LUF-R) a lufenuron foram caracterizadas pelo método de bioensaio com tratamento superficial da dieta artificial. As CL50 (I.C. 95%) estimadas para as lin

APA, Harvard, Vancouver, ISO, and other styles

19

Diffin, B. "The mechanism of metal detoxification of waste activated sludge by pH depression." Thesis, University of Newcastle Upon Tyne, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.353776.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

MILLER, NATALIE ELIZABETH. "ANALOGS OF CHLORAMPHENICOL AS MECHANISM-BASED INACTIVATORS OF RAT LIVER CYTOCHROMES P-450." Diss., The University of Arizona, 1987. http://hdl.handle.net/10150/184174.

Full text

Abstract:

The cytochrome P-450 dependent monooxygenase system plays a key role in the bioactivation and detoxication of xenobiotics. Isozyme-specific inhibitors of cytochrome P-450 may be useful in elucidating the role of particular isozymes in xenobiotic metabolism or in suppressing the bioactivation of xenobiotics and enhancing detoxication. The antibiotic chloramphenicol is a selective mechanism-based inactivator of rat liver cytochromes P-450, inactivating 6 of the 12 isozymes monitored, including the major phenobarbital-inducible isozyme PB-B. Analogs of chloramphenicol have been tested to determin

APA, Harvard, Vancouver, ISO, and other styles

21

Багмут, Ірина Юріївна, Ирина Юрьевна Багмут та Iryna Yuriivna Bahmut. "Структурно-метаболические нарушения и их механизмы при воздействии на организм олигоэфиров и патогенетическое обоснование принципов их ранней диагностики и коррекции". Thesis, Харьковская медицинская академия последипломного образования, 2015. http://essuir.sumdu.edu.ua/handle/123456789/42152.

Full text

Abstract:

Дисертація на здобуття наукового ступеня доктора медичних наук зі спеціальності 14.03.04 – патологічна фізіологія. – Суми, 2015. Дисертація присвячена проблемі патогенної дії хімічних чинників на організм. Метою дослідження було з`ясування структурно-метаболічних порушень та їх механізмів при дії олігоефірів на основі окису етилену та пропілену на організм і патогенетичне обґрунтування принципів їх ранньої діагностики та корекції. Вперше показано дозозалежне порушення стану фізико-хімічних і структурно-метаболічних властивостей біологічних мембран; виснаження активності механізмів детоксикаці

APA, Harvard, Vancouver, ISO, and other styles

22

Fleurbaix, Emmanuel. "Évaluation écotoxicologique des éléments terres-rares : approches cellulaires chez différentes espèces aquatiques." Electronic Thesis or Diss., Université de Lorraine, 2021. http://www.theses.fr/2021LORR0324.

Full text

Abstract:

Depuis 30 ans, l’utilisation croissante des Lanthanides dans les nouvelles technologies a entraîné des rejets importants de ces métaux vers les écosystèmes aquatiques. Dans une politique mondiale de développement durable visant à préserver la qualité des écosystèmes, la question de l’impact des Lanthanides sur les organismes aquatiques s’est naturellement posée. Néanmoins, les études restent peu nombreuses et aucun consensus ne subsiste concernant la toxicité des Lanthanides. Dans ce contexte, nous avons étudié la toxicité cellulaire des Lanthanides individuellement et en mélanges. Les effets

APA, Harvard, Vancouver, ISO, and other styles

23

Hailey, Alexander Lenard. "An Ancient Detoxification Mechanism Co-Opted in the Recent Transition to Mustard-Feeding by Drosophilid Flies: A Role for Glutathione S-Transferase." Thesis, The University of Arizona, 2013. http://hdl.handle.net/10150/297599.

Full text

Abstract:

Herbivorous insects comprise more than 25% of all known living species; however, knowledge of the evolutionary adaptive processes that enable insects to overcome toxic plant defense compounds is unknown. In this study, we investigated the possible evolutionary co-option of the generalized mercapturic acid detoxification pathway in mustard feeding Scaptomyza that recently derived from microbe feeding drosophilids. The first step of this pathway utilizes the ancient dimeric detoxification enzyme glutathione S-transferase (GST) to catalyze conjugation of toxic electrophilic substrates, such as mu

APA, Harvard, Vancouver, ISO, and other styles

24

Caetano, Soraia C. Marques. "Stress response mechanisms underlying metal detoxification in yeast." Doctoral thesis, 2017. http://hdl.handle.net/10362/77050.

Full text

Abstract:

" The Genomics and Stress Laboratory, at ITQB, headed by Prof. Claudina Rodrigues- Pousada, has been focused on the identification and characterization of stress-responsive genetic programs regulating metal toxicity in the yeast Saccharomyces cerevisiae(...)"

APA, Harvard, Vancouver, ISO, and other styles

25

Monteiro, Marta Isabel Póvoas. "Molecular mechanisms of BMAA stressresponse and detoxification in Mytillus galloprovincialis." Master's thesis, 2015. https://repositorio-aberto.up.pt/handle/10216/82383.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Monteiro, Marta Isabel Póvoas. "Molecular mechanisms of BMAA stressresponse and detoxification in Mytillus galloprovincialis." Dissertação, 2015. https://repositorio-aberto.up.pt/handle/10216/82383.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Gonzalez-Rey, Maria. "Metals and detoxification mechanisms in shrimp: comparative approach between hydrothermal vent fields and estuarine environments." Master's thesis, 2007. http://hdl.handle.net/10400.1/370.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Ji, Mikyoung Lee. "Functional evaluation of the mechanisms of reactive oxygen detoxification in the hyperthermophilic archaeon Pyrococcus furiosus using complementation studies." 2003. http://www.lib.ncsu.edu/theses/available/etd-08282003-132352/unrestricted/etd.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Sahu, Chandan. "Theoretical and computational study of properties and detoxification mechanisms of chemical warfare agents, toxic chemicals and enzyme inhibitors." Thesis, 2019. http://hdl.handle.net/10821/8261.

Full text

Abstract:

The thesis deals with the reaction mechanism, kinetics, molecular docking, simulation and thermochemistry of molecules having biological and toxicological interest. The high-level theoretical methods are used for accurate results and predictions.An introduction to the thesis is given in the first chapter for understanding the biological and toxicological chemistry. The second chapter describes briefly theoretical methods and techniques of computational chemistry. The rest of the chapters of the thesis are based on the published papers or on the manuscripts currently under consideration for pub

APA, Harvard, Vancouver, ISO, and other styles

30

LING, THAI-YEN, and 林泰元. "The study of detoxification and metabolism mechanism to cadmium in yeast." Thesis, 1992. http://ndltd.ncl.edu.tw/handle/30007903941770200671.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Forrest, Dana Nichole. "Bile salt hydroxylation as a mechanism for detoxification in SPGP knockout mice." Thesis, 2003. http://hdl.handle.net/2429/14114.

Full text

Abstract:

In humans, mutations in the Sister of P-glycoprotein (spgp) gene involved in bile salt transport lead to progressive familial intrahepatic cholestasis type 2 (PFIC2). Generation of the spgp[sup -/-] mice demonstrated that the mice are not affected as severely as humans. Analysis of the biliary bile salt pool of the spgp[sup -/-] mice indicated the presence of tetrahydroxylated bile salts. However, the transport rate of the hydrophilic bile salts was unaffected. Examination of tetrahydroxylated bile salts as a possible detoxification mechanism requires identification and characterization of the

APA, Harvard, Vancouver, ISO, and other styles

32

Tang, Chia-Yuan, and 湯佳元. "The Study of Detoxification Mechanism in MousePulmonary Stem/Progenitor Cells for Paraquat Intoxication." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/61750319663025277041.

Full text

Abstract:

碩士<br>國立臺灣大學<br>毒理學研究所<br>99<br>Paraquat (PQ) is one of the most widely used herbicides in the world, and it is the well-known pneumotoxicant. Paraquat accumulates mainly in the lungs through polyamine uptake system and undergoes a process of redox-cycling, which leads to reactive oxygen species (ROS) production at the expense of NADPH. We have set a primary culture of mouse pulmonary stem/progenitor cells (mPSCs) which includes epithelial colony cells and surrounding stroma cells in theculture system. However, the toxicity of cellular response to PQ in mPSCs was not elucidated. According to o

APA, Harvard, Vancouver, ISO, and other styles

33

Lin, Wan-Ting, and 林婉婷. "Resistance mechanism of goosegrass (Eleusine indica (L.) Gaertn.) resistant to fluazifop-butyl - metabolic detoxification." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/pkxzed.

Full text

Abstract:

碩士<br>國立中興大學<br>農藝學系所<br>102<br>Fluazifop-P-butyl, a selective graminicide, is widely used to control annual grass weeds. The action mechanism of this herbicide is to inhibit the activity of acetyl-CoA carboxylase (ACCase; EC 6.4.1.2), which is responsible for the lipid biosynthesis. In order to explore the resistance mechanism, resistant (R)- and susceptible (S)-biotype of goosegrass [Eleusine indica (L.) Gaertn.] treated with 14C-fluazifop-P-butyl were studied. Although no significant difference of herbicide uptake between R- and S-biotype, and even the higher translocation rate of 14C-fluaz

APA, Harvard, Vancouver, ISO, and other styles

34

Lee, Yen-Lin, and 李燕霖. "Inhibitory mechanism of quercetin and its metabolites on the growth of human hepatoma cells Hep 3B and the effects of quercetun on glutathione-related detoxification and antioxidation system of primary rat hepatocytes." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/12362339020312741590.

Full text

Abstract:

碩士<br>國立臺灣大學<br>食品科技研究所<br>93<br>In this study, quercetin and quercetin metabolites, quercetin glucuronides and quercetin sulfates, were used to investigate the anti-proliferation effects and mechanism on human hepatoma cells Hep 3B and the effect on glutathione-related detoxification and antioxidation system of primary rat hepatocytes. We found that after 48 hr treatment, quercetin inhibited the growth of Hep 3B cells and the IC50 value was 335 μM. With much lower IC50 values, two samples containing different amount of quercetin glucuronides and quercetin sulfates showed stronger anti-prolife

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!