Relevant bibliographies by topics / Diagnostic Techniques and Therapeutic Interventions / Dissertations / Theses
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Dissertations / Theses on the topic 'Diagnostic Techniques and Therapeutic Interventions'

Author: Grafiati
Published: 7 June 2025
Last updated: 2 August 2025

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1

Abel, Mark Joshua. "Novel therapeutic and diagnostic ultrasound techniques in cancer management." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/47909.

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Introduction: The aim of this thesis is to assess novel therapeutic and diagnostic ultrasound techniques in cancer management. A drive to improve prognosis in cancer patients has resulted in a vast array of recent medical advances and new approaches using ultrasound technology may enhance outcome in patients with a diagnosis of malignancy. Methods: A new 256 element random phased-array high intensity focused ultrasound (HIFU) device was designed, developed and tested for use in treating hepatic tumours. An existing intra-cavitary HIFU transducer (Sonablate 500®) currently under investigation f
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2

Tricou, Vianney M. "Dengue diagnostics and therapeutic interventions in Viet Nam." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:46dfff8c-f7d2-4c43-b053-a5438531290a.

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Dengue is a major public health problem that affects tens of millions of people annually in tropical and sub-tropical countries. This acute viral infection happens to be severe and even life threatening but there is still no available drug or vaccine. Previous studies have noted early higher viral burden in patients who develop more severe symptoms suggesting that administration of a potent and safe antiviral may prevent progression to severe dengue. To verify this hypothesis, we have conducted the first RCT directed towards reducing the viral burden in vivo by administrating chloroquine (CQ),
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3

Hearnden, Vanessa. "Developing tissue engineered models of oral mucosa and oral cancer to study novel therapeutic and diagnostic techniques." Thesis, University of Sheffield, 2010. http://etheses.whiterose.ac.uk/1174/.

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In the UK in 2008 over 1,800 people died from oral cancer. Despite advances in surgery and therapy the survival rates for those diagnosed with oral cancer have not significantly improved over the past 20 years. There is a need for both better detection and treatment. Early detection could reduce these mortality rates but unfortunately diagnosing oral cancer, which is often symptomless, in the early stages of the disease is incredibly challenging. More targeted treatments for oral cancer are also needed which can be administered to the site of disease with higher efficiency and accuracy to redu
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4

Zaenker, Pauline. "The identification and validation of a diagnostic signature of tumour-associated autoantibodies for the early diagnosis of cutaneous melanoma." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2018. https://ro.ecu.edu.au/theses/2129.

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Background Cutaneous melanoma is an aggressive cancer with a high propensity to metastasise. Melanomarelated fatalities are however preventable through early detection and complete surgical excision of the primary tumour. Current screening methods for melanoma are effective but limited to the visual examination of the skin, potentially leading to a delay in diagnosis of less obvious lesions. Circulating biomarkers have been proposed to aid with early melanoma diagnosis and are easily accessible by routine blood collection. However, despite intensive scientific efforts, there are currently no b
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5

Hawkins, Rodney J. "EPICARDIAL WIRELESS PACEMAKER FOR IMPROVED LEFT VENTRICULAR RESYNCHRONIZATION (CONCEPTUAL DESIGN)." DigitalCommons@CalPoly, 2010. https://digitalcommons.calpoly.edu/theses/431.

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The human body is a well tuned mechanism where systems work in synergy to provide a healthy quality of life. The human circulatory system transports oxygenated blood from the heart to the rest of the body delivering the proper nutrients for cells to function. When the heart malfunctions, serious complications can arise leading to sudden cardiac arrest. Congestive heart failure (CHF) is one heart disease that affects the synchrony of the heart’s ventricles. Cardiac resynchronization therapy (CRT) has been widely accepted as a treatment for CHF. Similar to traditional dual chamber pacing tec
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6

Kandrack, Allison. "Using Therapeutic Play to Help Children Cope with Changing Social roles Within the Family after Death has Occurred." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/secfr-conf/2019/schedule/4.

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Play can be beneficial and effective for children experiencing the stress, fears, and anxieties associated with illness or death by expressing their feelings into activity (Brown 2018). It can be difficult for children to verbally communicate complex emotions because they usually are unsure of what words to say to express their emotions. Therapeutic play is a great coping mechanism for coping with death because it allows children to express their emotions through play. Professionals working with children would be better equipped to meet children’s needs with a firmer understanding on the ways
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7

Brown, Anna Laura. "Bismuth Nanoparticles as Medical X-ray Contrast Agents: Synthesis, Characterization and Applications." PDXScholar, 2013. https://pdxscholar.library.pdx.edu/open_access_etds/1523.

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Bismuth based nanomaterials have recently attracted attention as heavy element X-ray contrast agents because of the high atomic number and predicted biological compatibility of bismuth. Nanoparticle X-ray contrast agents may enable a number of novel medical imaging applications, including blood pool and site-directed imaging. However these hypothetical applications are hindered by lack of suitable synthetic methods for production of imaging agents. This dissertation describes synthesis of a novel class of bismuth nanoparticles that are aqueously stabilized using poly and monosaccharides. These
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8

West, Lauren J. "A Standoff Approach to Monitoring Infant Apnea." DigitalCommons@CalPoly, 2010. https://digitalcommons.calpoly.edu/theses/311.

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The focus of this thesis was to capture and measure carbon dioxide concentrations upon exhalation to determine if an apnea event is occurring. Research in the fields of respiratory physiology and apnea built the foundation for the design of the standoff infant apnea monitor. The monitor is designed to track infant respiration using carbon dioxide and sound signatures of breath without touching the infant. Each detection system, audio and carbon dioxide, were designed separately and brought together for a final proof-of-concept device. The software was developed using LabView and run on a Netbo
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9

Santana, Sondra Michelle Phipps. "Practitioners' Use of Clinical Practice Guidelines: An Evidence-Based Approach." UNF Digital Commons, 2013. http://digitalcommons.unf.edu/etd/462.

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Pre-diabetes is a serious health problem in the United States. Distinguished by plasma glucose levels that are above the normal threshold, patients with pre-diabetes are 10 times more likely to develop type 2 diabetes. Patients with pre-diabetes suffer the same complications as patients with diabetes including diabetic retinopathy, nephropathy, and microalbuminuria. There is considerable evidence to support the idea that early identification and aggressive treatment of pre-diabetes has the potential to delay disease progression. The American Diabetes Association’s clinical practice guideline r
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10

Ross, Caitlin. "The use and effectiveness of behaviour change techniques, and specifically the use of 'if-then' planning (or implementation intentions), in therapeutic interventions for mental health conditions." Thesis, University of Sheffield, 2018. http://etheses.whiterose.ac.uk/19549/.

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11

Rogers, Lorna. "A patient management program: The evaluation of a combined pre-admission and early discharge program." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 1997. https://ro.ecu.edu.au/theses/903.

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The purpose of this descriptive study was to describe the evaluation of a 'Patient Management Program'. This managed care type of program combined a Pre-Admission Clinic and an Early Discharge Program. It was established as a twelve month pilot program at a major Western Australian public teaching hospital in January 1995. It aimed to provide a more efficient health service by replacing part of elective surgical patients' inpatient care with outpatient services. The first component of the Program was the Pre-Admission Clinic, which allowed patients to undergo pre-operative assessment and testi
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12

Davenport, Mary Jo. "The Effect of Sternocleidomastoid Muscle Activation Pattern and Feedback Condition on the Vestibular Evoked Myogenic Potential." Digital Commons @ East Tennessee State University, 2010. https://dc.etsu.edu/etd/1776.

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The vestibular evoked myogenic potential (VEMP) has been shown to be clinically useful in providing diagnostic information regarding the function of the otolith receptors, inferior vestibular nerve, and vestibulospinal pathways. The VEMP is a biphasic response elicited by loud clicks or tone bursts and recorded from the tonically contracted sternocleidomastoid (SCM) muscle. Because the VEMP is an inhibitory response, it is important to investigate stimulus and parameter characteristics in order to determine the optimal test protocol and maximize clinical usefulness. The aims of this study were
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13

Tageson, Mackenzie Elizabeth. "FUNCTIONAL 3-D CELLULOSE & NITROCELLULOSE PAPER-BASED, MULITPLEX DIAGNOSTIC PLATFORMS WITHOUT COUPLING AGENTS." DigitalCommons@CalPoly, 2013. https://digitalcommons.calpoly.edu/theses/1128.

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The purpose of this thesis was to demonstrate device functionality of 3-D paper-based, multiplex platforms, µPADs, without the use of coupling agents between layers. Previously, these platforms were fabricated with double-sided tape and cellulose powder to try to augment proper fluid routing, but difficulties with this method occurred. An acrylic housing unit with strategically placed pressure tabs was designed to aid horizontal and vertical fluid routing through the platform, thus eliminating the inconsistencies associated with coupling agents. Channel characterization studies, a COMSOLTM sim
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14

Gitchel, George Thomas Jr. "Development of an Accurate Differential Diagnostic Tool for Neurological Movement Disorders Utilizing Eye Movements." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/4109.

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Parkinson’s disease and Essential tremor are the two most prevalent movement disorders in the world, but due to overlapping clinical symptoms, accurate differential diagnosis is difficult. As a result, approximately 60% of patients with movement disorders symptoms will have their diagnosis changed at least once before death. By their subjective nature, clinical exams are inherently imprecise, leading to the desire to create an objective, quantifiable test for movement disorders; a test that currently is elusive. Eye movements have been studied for a century, and are widely appreciated to be
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15

Marais, Ade. "Neurocorrelates of the Mirror Neuron System in Children with Chromosome 22q11.2 Deletion Syndrome." ScholarWorks@UNO, 2017. https://scholarworks.uno.edu/td/2422.

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Activation of brain regions that make up the mirror neuron system (MNS) is thought to reflect processing and perceiving behavior, action, and intentionality of other organisms. Sensing and perceiving motor behavior in others is an important component of understanding and participating in social interactions. Children with chromosome 22q11.2 deletion syndrome (22q11.2DS) are diagnosed with serious medical, cognitive, and socio-emotional symptoms. Atypical development and function of the MNS may underpin some aspects of socio-emotional impairment and autism spectrum disorder (ASD)-like symptomol
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16

Mehnert, Andrew. "Digital Morphometry : A Taxonomy Of Morphological Filters And Feature Parameters With Application To Alzheimer's Disease Research." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 1994. https://ro.ecu.edu.au/theses/1468.

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In this thesis the expression digital morphometry collectively describes all those procedures used to obtain quantitative measurements of objects within a two-dimensional digital image. Quantitative measurement is a two-step process: the application of geometrical transformations to extract the features of interest, and then the actual measurement of these features. With regard to the first step the morphological filters of mathematical morphology provide a wealth of suitable geometric transfomations. Traditional radiometric and spatial enhancement techniques provide an additional source of tr
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17

Stallard, Derek. "A systematic column performance comparison for the confirmation of opioids used in pain management by LC-MS." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/honors/189.

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In this study, three different chromatographic column chemistries (C18, Pentafluorophenyl (PFP), Hydrophilic Interaction Chromatography (HILIC)) were compared under optimal conditions to determine which stationary performed best in the separation and detection of a mixture of opioids using LC-MS. Furthermore, these stationary phases were examined in three different column technologies – traditional silica, porous shell, and porous polymer (PRP). The PRP column had the best peak shape for all 13 opioids and dominated for later-eluting compounds. In terms of column reproducibility, the Hamilto
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18

Beasley, Aaron. "Development of novel tests to improve the management of Uveal Melanoma." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2021. https://ro.ecu.edu.au/theses/2415.

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Uveal melanoma (UM) is the most common intraocular malignancy in adults, affecting about 200 Australians per annum. Unfortunately, up to 50% of patients will develop incurable metastatic disease despite effective treatment of the localised disease. Once metastases are detected, 92% of patients will die within two years. Specific genetic mutations, somatic copy number alterations (SCNAs), and gene expression profiles can accurately stratify patients who will develop metastatic disease. However, determination of prognosis requires an intraocular biopsy which is not always performed outside of ce
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19

Hassan, Zaneera. "Metaproteomic Investigation of the Vaginal Microbiome in Pregnancy." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/6015.

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The development of early diagnostics and prevention strategies for preterm birth is an important global health challenge with the potential to impact over 15 million children annually, by improving health outcomes and reducing economic burden. Advances in microbial sequencing technology have opened the door to 16S rRNA gene survey, whole metagenomics, and whole transcriptomics, providing molecular evidence that the composition of the vaginal microbiome affects pregnancy outcomes in women, particularly those of African descent. A current gap in our molecular level understanding of the vaginal m
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20

Chipman, Christopher L. "Maximization of Hydraulic Flow through Small Flexible Polymer Tubes by the Optimization of Tubing Stiffness and Wall Thickness." BYU ScholarsArchive, 2013. https://scholarsarchive.byu.edu/etd/3728.

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As illness becomes increasingly more common in the United States and across the globe, the need for better and faster medical treatment is greater than ever. The purpose of this work is to evaluate advanced polymers and polymer composites that will provide for increased fluid flow while maintaining outer dimensional, stiffness, and burst resistance characteristics when compared to a currently used material. A polymer configuration consisting of a proprietary formulation that has a durometer approximately 10% higher than the current material with an outer wall thickness of approximately .020" p
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21

Dhiman, Kunal. "Utility of CSF biomarkers for the diagnosis, prognosis and assessment of cognitive decline in Alzheimer’s disease." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2020. https://ro.ecu.edu.au/theses/2284.

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Alzheimer’s disease (AD) is a slow and progressive neurodegenerative disorder.With new treatment strategies failing in clinical trials, there is a need to initiate a targeted treatment strategy, by administering the right medication, to the right individual, at the right stage. This concept of precision medicine not only requires diagnosis at the preclinical stage, but a thorough understanding of the stage-associated neuropathological changes that occur along the continuum of AD. Pathophysiological biomarkers indicative of neuropathological changes in the brain are needed to identify the precl
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22

Young, Andrew Coady. "A Consensus Model for Electroencephalogram Data Via the S-Transform." Digital Commons @ East Tennessee State University, 2012. https://dc.etsu.edu/etd/1424.

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A consensus model combines statistical methods with signal processing to create a better picture of the family of related signals. In this thesis, we will consider 32 signals produced by a single electroencephalogram (EEG) recording session. The consensus model will be produced by using the S-Transform of the individual signals and then normalized to unit energy. A bootstrapping process is used to produce a consensus spectrum. This leads to the consensus model via the inverse S-Transform of the consensus spectrum. The method will be applied to both a control and experimental EEG to show how th
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23

Russell, Alyce Christine. "The N-Glycosylation of immunoglobulin G as a novel biomarker of Parkinson’s disease." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2015. https://ro.ecu.edu.au/theses/1617.

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For neurodegenerative diseases, interventions during the early stages of the disease, before significant neurodegeneration has occurred, are associated with an increased probability of slowing or halting the disease process. In order to intervene early, it is essential that an accurate diagnosis is obtained and that disease progression can be monitored. This is particularly relevant for Parkinson’s disease (PD; International Classification of Diseases version 10) because significant neurodegeneration has already occurred by the time the clinical motor symptoms are present. Therefore, the devel
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24

Coney, Sonia Lorraine. "The Development of the Self-Injury Self-Report Measure." Digital Commons @ East Tennessee State University, 2007. https://dc.etsu.edu/etd/2116.

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Despite the amount of research that has been conducted on self-injury there is a lack of empirically validated instruments with which to measure self-injurious behavior. The present study developed a measure to examine self-injury and the associated features. Undergraduate students (n = 184) were administered a set of surveys to assess demographics, self-injurious behavior, suicidal ideation, Axis I and Axis II disorders, and impulsivity. Results indicated that a reliable measure, able to assess the extent of self-injury as well as associated features, was developed. Such a measure will enable
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Rife, Furnell. "Strategies Used by Hospitals in a Southeastern State to Reduce Catheter Associated Urinary Tract Infections: Comparing the Outcomes by Hospital Structure and Processes." Digital Commons @ East Tennessee State University, 2012. https://dc.etsu.edu/etd/1490.

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Catheter-Associated Urinary Tract Infections are considered a clinical indicator of quality of care. A descriptive research study was conducted to identify the strategies used by hospitals to reduce or eliminate CAUTIs. Infection Control Preventionists were surveyed. In a predominately rural southeastern state, this study demonstrated that about 40% of hospitals surveyed are implementing CAUTI prevention processes.
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26

Drozdova, Alesya. "Genetic determinants of cognitive heterogeneity in Parkinson’s disease." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2016. https://ro.ecu.edu.au/theses/1942.

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People with Parkinson’s disease (PD) display an increased rate of cognitive decline heterogeneous in its presentation and detrimental to a person’s quality of life. The causes of cognitive diversity are unclear, however exploration of the genetic contribution to cognitive profiles is unearthing promising developments. This thesis comprises three studies that use statistical analysis of individual differences to unravel the genetic contribution of genes central to alpha-synuclein (-syn), tau, and noradrenergic pathologies to cognitive outcomes in a Western Australian community-based PD cohort.
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Holtman, Catherine E. "Rapid Detection of Streptococcus mutans in Saliva." Digital Commons @ East Tennessee State University, 2012. https://dc.etsu.edu/etd/1460.

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Documentation exists that mothers can pass the cariogenic bacteria Streptococcus mutans to their infants. The newest technology to identify Streptococcus mutans is a rapid detection saliva test. Two hundred patients above the age of 18 were targeted using random selection in a Louisville, Kentucky dental office. Patients signed an informed consent form and were given a qualifying questionnaire. Patients received 2 bitewing x-rays and a charted DMFT index and were administered the saliva test. While the null hypothesis was rejected using the chi square test, the results were inconclusive due to
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Barbre, Evan Allen. "LASER ETCHED PMMA MICROFLUIDIC CHIP DESIGN AND MANUFACTURE WITH APPLICATIONS IN CAPILLARY ZONE ELECTROPHORESIS." DigitalCommons@CalPoly, 2011. https://digitalcommons.calpoly.edu/theses/448.

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This thesis encompasses a feasibility study of using low-cost materials to manufacture microfluidic chips that can perform the same functions as chips manufactured using traditional methods within an acceptable range of efficiency of chips created with more exotic methods and materials. The major parts of the project are the selection and characterization of the fabrication methods for creating the channels for fluid flow, the methods for sealing the channels to create a usable chip and the electrophoretic separations of carboxylated microspheres of different potentials. In this work we seek
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29

Leclair, Susan J. "The Correlation Between the Levels of Education of Clinical Laboratory Personnel and the Accuracy of Peripheral Blood Smear Results." ScholarWorks, 2001. https://scholarworks.waldenu.edu/dissertations/1393.

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This study correlated the performance accuracy of peripheral blood differentials evaluated by clinical laboratory scientists and clinical laboratory technicians. Fifty-one senior-year students from four clinical laboratory science baccalaureate programs and 37 second-year students from five clinical laboratory technician programs were given 10 peripheral blood differentials to perform. Results were compared to the values assigned by the Rajamaki method of proficiency testing. There was a significant discrepancy in the levels of accuracy between the two cohorts, suggesting that the results of p
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McEvoy, Ashleigh Cavell. "Circulating tumour DNA: A non-invasive biomarker for melanoma." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2018. https://ro.ecu.edu.au/theses/2064.

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Cutaneous melanoma accounts for 90% of all skin cancer deaths (Balch et al., 2010) and is responsible for 3.6% of deaths from cancer in Australia (Australian Institute of Health and Welfare, 2016). Whilst early detection and successful surgical removal of primary melanomas have improved survival rates (DeSantis et al., 2014), approximately 30% of these patients will have disease recurrence at some point in their lives (Soong et al., 1992; Soong et al., 1998). This is despite being considered disease free following treatment, which may have included surgical removal of the primary and/or its me
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Marsavela, Anda-Gabriela. "Assessment of the clinical validity of ctDNA Analysis for melanoma management." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2021. https://ro.ecu.edu.au/theses/2407.

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Metastatic melanoma is responsible for almost 80% of all skin cancer-related deaths and the incidence of people affected continues to rise worldwide. The emergence of targeted therapy and immune-checkpoint inhibitors has improved the clinical management of melanoma, but durable survival benefit is only seen in a minority of patients. The use of these very expensive systemic therapies on all appropriate patients also poses a high economic burden on health systems across numerous countries. Currently, surveillance for treatment failure is not optimal. Thus, reliable and accurate biomarkers of pa
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32

Larcombe, Danica-Lea. "Health, lifestyle and nature disconnect in high-rise apartment dwellers." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2021. https://ro.ecu.edu.au/theses/2465.

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Disconnection from nature puts high-rise dwellers at risk of chronic disease and poor mental health, two major healthcare budget items. Many reports in the literature state compromised mental health, partly due to the ‘grey’ landscape of many apartment buildings, particularly in low socioeconomic areas. Lifestyle is also affected by influences of floor level and sociodemographic status. In high-density cities around the world, high-rise developments (solving urban sprawl) are increasingly being built without consideration for incorporating greenspace. The sheer height of these buildings means
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Haraszti, Reka A. "Engineered Exosomes for Delivery of Therapeutic siRNAs to Neurons." eScholarship@UMMS, 2018. https://escholarship.umassmed.edu/gsbs_diss/971.

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Extracellular vesicles (EVs), exosomes and microvesicles, transfer endogenous RNAs between neurons over short and long distances. We have explored EVs for siRNA delivery to brain. (1) We optimized siRNA chemical modifications and siRNA conjugation to lipids for EV-mediated delivery. (2) We developed a GMP-compatible, scalable method to manufacture active EVs in bulk. (3) We characterized lipid and protein content of EVs in detail. (4) We established how protein and lipid composition relates to siRNA delivering activity of EVs, and we reverse engineered natural exosomes (small EVs) into artific
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Belanger, Annie. "Brain Basis of the Placebo Effect: A Proposed Integrative Model Implicating the Rostral Anterior Cingulate." Scholarship @ Claremont, 2013. http://scholarship.claremont.edu/scripps_theses/272.

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How is the brain capable of mediating pain relief via the mind alone? Placebo analgesia is just such a case, wherein an inert substance yields relief from a number of pain inducing stimuli. Scholars typically separate several factors thought to contribute to the placebo effect into psychological and neurobiological influences. Psychological mechanisms include expectation and conditioning of analgesic effects, while neurobiological mechanisms implicate the opioidergic descending pain system. The current paper proposes an integrative model in which the rostral anterior cingulate cortex (rACC), i
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Thapa, Bishnu Bahadur. "DEVELOPMENT OF A PATIENT SPECIFIC IMAGE PLANNING SYSTEM FOR RADIATION THERAPY." UKnowledge, 2013. http://uknowledge.uky.edu/physastron_etds/11.

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A patient specific image planning system (IPS) was developed that can be used to assist in kV imaging technique selection during localization for radiotherapy. The IPS algorithm performs a divergent ray-trace through a three dimensional computed tomography (CT) data set. Energy-specific attenuation through each voxel of the CT data set is calculated and imaging detector response is integrated into the algorithm to determine the absolute values of pixel intensity and image contrast. Phantom testing demonstrated that image contrast resulting from under exposure, over exposure as well as a contra
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Santoso, Benedicta. "The effect of sperm apoptosis, Reactive Oxygen Species (ROS) and semen sample handling on sperm parameters and Assisted Reproductive Technology (ART) outcomes." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2020. https://ro.ecu.edu.au/theses/2373.

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Overall, this doctoral study aimed to contribute to the existing knowledge and clinical practice regarding male infertility, especially in relation to the potential sources and clinical impact of sperm apoptosis and reactive oxygen species (ROS) in the context of assisted reproductive technology (ART). This thesis encompasses three independent studies, each of which addresses a single aim related to different aspects of male infertility and ART practices. Study 1 examined the relationship between sperm apoptosis and ROS levels and ART outcomes. On the day of oocyte retrieval, the levels of spe
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Mi, Hongmei. "PDE modeling and feature selection : prediction of tumor evolution and patient outcome in therapeutic follow-up with FDG-PET images." Rouen, 2015. http://www.theses.fr/2015ROUES005.

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La radiothérapie adaptative peut potentiellement améliorer le résultat du traitement du patient à partir d'un plan de traitement ré-optimisé précoce ou au cours du traitement en prenant en compte les spécificités individuelles. Des études prédictives sur le suivi thérapeutique du patient pourraient être d'intérêt sur la façon d’adapter le traitement à chaque patient. Dans cette thèse, nous menons deux études prédictives en utilisant la tomographie par émission de positons (TEP). La première étude a pour but de prédire l'évolution de la tumeur pendant la radiothérapie. Nous proposons un modèle
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Paudel, Iru. "Sab Concentration Determines the Chemotherapeutic Efficacy in Gynecological Cancer." FIU Digital Commons, 2018. https://digitalcommons.fiu.edu/etd/3707.

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The American Cancer Society predicts there will be 110,070 new cases and 32,120 deaths due to gynecological malignancies in 2018. A major contributing factor to the high mortality associated with gynecological cancers is the recurrence of treatment-resistant tumors. Ovarian cancer (OC) remains the most lethal gynecological malignancy, yet the mechanisms responsible for regulating tumor resistance and vulnerability are largely unknown or undruggable. Therefore, the goal of this research is to identify mechanisms responsible for therapeutic resistance in gynecological cancers and discover innova
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Abdelraouf, Mostafa. "Virtual reality for the characterization of blood vessel to airway geometric relationships." Thesis, University of Iowa, 2018. https://ir.uiowa.edu/etd/6355.

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An increase in the cross-sectional area (CSA) of the pulmonary arteries has been implicated in the progression of emphysema in COPD patients. Standardization of vessel size requires matching segments of the airway with their corresponding blood vessels. Automated matching is still error-prone, and manual matching by sifting through 2D slices is tedious and time-consuming. We propose a virtual reality (VR) system for the visualization of the airway and the vascular tree as a means of streamlining the verification of appropriate airway/vascular segment pairs selected for quantitation of arterial
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Bartlett, Danielle Megan. "The utility of multidisciplinary rehabilitation as a treatment strategy for circadian rhythm and sleep disturbances in premanifest Huntington’s Disease." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2018. https://ro.ecu.edu.au/theses/2143.

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Background: Huntington’s disease (HD) is a rare, neurodegenerative disease caused by an expanded cytosine-adenine-guanine (CAG) sequence in the Huntingtin gene, resulting in the production of an aberrant protein, mutant huntingtin (mHTT). The mHTT protein exhibits a toxic loss and gain in function, leading to degeneration of neurons in the brain. Consequently, the classic triad of motor, cognitive and mood features of the disease develop. Among the earliest features of HD are circadian rhythm and sleep disturbances. These anomalies present many years prior to formal clinical diagnosis of HD an
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Riblett, Matthew J. "Motion-Induced Artifact Mitigation and Image Enhancement Strategies for Four-Dimensional Fan-Beam and Cone-Beam Computed Tomography." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5542.

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Four dimensional imaging has become part of the standard of care for diagnosing and treating non-small cell lung cancer. In radiotherapy applications 4D fan-beam computed tomography (4D-CT) and 4D cone-beam computed tomography (4D-CBCT) are two advanced imaging modalities that afford clinical practitioners knowledge of the underlying kinematics and structural dynamics of diseased tissues and provide insight into the effects of regular organ motion and the nature of tissue deformation over time. While these imaging techniques can facilitate the use of more targeted radiotherapies, issues surrou
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42

Hojati, Ashkhan. "Pharmacologic profiling of novel compounds via fluorometric analyses of monoamine transporter responses." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5983.

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In humans and other organisms, monoaminergic systems are crucial in neuronal function and behavior. The monoamine transporters (MATs), which can be found on the presynaptic plasma membrane of neurons in the central nervous system (CNS), are crucial in the regulation of neurotransmitter concentration in the synaptic cleft. As the duration and concentration of neurotransmitters in the cleft affect further downstream signaling responses, these proteins are important targets for both understanding neuronal physiology and compounds of interest. Multiple theories exist proponing the contribution of
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Dutro, Anna Rae. "Light Image Therapy in the Health Care Environment." Digital Commons @ East Tennessee State University, 2007. https://dc.etsu.edu/etd/2060.

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Use of positive distraction in the built healthcare environment to assist in alleviating stress in a patient was investigated. A backlit light image was mounted in the ceiling of an examination room to create a positive distraction for patients in the ETSU Pediatric Clinic in Johnson City, TN. Survey instruments were used to collect sample data from patients and physicians in a randomized, balanced controlled study designed to determine if patients experienced less stress in the room with the backlit image as compared to other rooms (treatments). Although a statistical difference was not deter
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Oliver, Kim. "An assessment of nurses’ experiences of work related stress through self-reporting and hair cortisol analysis, in a metropolitan hospital in Western Australia." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2017. https://ro.ecu.edu.au/theses/2002.

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The aim of this study was to assess how years of experience and practice area influence work related stress amongst 1,200 nurses employed in a metropolitan hospital environment in Western Australia. A combination of self-administered questionnaires and hair cortisol, an objective stress biomarker, was utilised to measure stress levels and to relate these to practice area, age and experience. Questionnaire results indicated that there was a higher level of perceived stress for 40% of this cohort of nurses; the study methodology was able to unearth noteworthy factors within a local WA nursing po
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Peretti, Madeline. "DNA methylation of the clusterin promoter: Associations with Alzheimer’s Disease risk and related phenotypes." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2019. https://ro.ecu.edu.au/theses/2172.

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Background In 2017 approximately 50 million people worldwide were living with dementia. With Alzheimer’s disease (AD), accounting for 50-70% of dementia cases making this debilitating disease, with no current effective prevention, treatment or cure, a critical healthcare concern. Genome wide association studies (GWAS) have identified a number of risk genes for late onset AD (LOAD); Apolipoprotein E (APOE), a gene involved in the cholesterol/lipid pathway is considered the gene with the greatest risk. The third most associated AD risk gene is Clusterin (CLU), is also involved in the cholesterol
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Winston, Thomas George. "An Empirical Investigation of Privacy and Security Concerns on Doctors’ and Nurses’ Behavioral Intentions to Use RFID in Hospitals." NSUWorks, 2016. http://nsuworks.nova.edu/gscis_etd/371.

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Radio frequency identification (RFID) technology is a useful technology that has myriad applications in technology, retail, manufacturing, and healthcare settings. Not dependent upon line-of-sight, RFID can scan devices in their proximity and report the information to connected (wired or other wireless) information systems. Once touted as the panacea for home healthcare, RFID devices can add benefit to patients in remote settings. RFID devices have been used to optimize systems in areas such as manufacturing and healthcare to expose inefficiencies in a system or process. Unlike manufacturing,
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Adams, William P. "Thyroid Hormone as a Method of Reducing Damage to Donor Hearts after Circulatory Arrest." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4766.

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There is a chronic lack of donor hearts to meet the need for heart transplant both in the US and worldwide. Further, the use of available hearts is limited by the short period between collection and implantation during which the heart can be safely preserved ex vivo. Using mid-thermic Langendorff machine perfusion, we have been able to preserve the metabolic function of a healthy heart for up to 8 hours, twice the limit for current static cold storage. We have also been able to preserve the metabolic function of a damaged DCD Heart collected 30 minutes after cardiac arrest for a period of 8 ho
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Fung, Kandace. "Detection of Sickle Cell Disease-associated Single Nucleotide Polymorphism Using a Graphene Field Effect Transistor." Scholarship @ Claremont, 2019. https://scholarship.claremont.edu/cmc_theses/2262.

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Sickle Cell Disease (SCD) is a hereditary monogenic disorder that affects millions of people worldwide and is associated with symptoms such as stroke, lethargy, chronic anemia, and increased mortality. SCD can be quickly detected and diagnosed using a simple blood test as an infant, but as of now, there is currently limited treatment to cure an individual of sickle cell disease. Recently, there have been several promising developments in CRISPR-Cas-associated gene-editing therapeutics; however, there have been limitations in gene-editing efficiency monitoring, which if improved, could be benef
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Robinson, Callum Andrew. "The cryopreservation of human semen, and subsequent evaluation of a commercially-available device to isolate motile sperm." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2018. https://ro.ecu.edu.au/theses/2146.

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The cryopreservation of human semen is a vital asset in assisted reproductive technologies (ART). Although advances have been in the freezing of sperm, further refinement is both necessary and ongoing. Computer-assisted semen analysis (CASA) has been increasingly utilised in both research and diagnostic however there are a range of variables that must first be controlled in order to produce reliable measurements. Following thawing, sperm must be isolated from both the original seminal plasma and the cryoprotectants; the two most used isolation methods include density gradient centrifugation (D
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Creegan, Rhona. "Identification of plasma lipid biomarkers in Alzheimer's disease." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2014. https://ro.ecu.edu.au/theses/1340.

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Alzheimer’s disease (AD), the commonest form of dementia, is a chronic, progressive neurodegenerative disease which manifests clinically as a slow global decline in cognitive function, including deterioration of memory, reasoning, abstraction, language and emotional stability, culminating in a patient with end-stage disease, totally dependent on custodial care. With an ageing population, there is predicted to be a marked increase in the number of people diagnosed with AD in the coming decades, making this a significant challenge to socio-economic policy and aged care. Currently there is no cur
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