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Journal articles on the topic 'Diagnostic Techniques and Therapeutic Interventions'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Fathalizadeh, Alisan. "Diagnostic and Therapeutic Endoscopy: An Overview." Digestive Disease Interventions 02, no. 04 (2018): 299–313. http://dx.doi.org/10.1055/s-0038-1676063.

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AbstractAs surgical and interventional techniques are becoming progressively less invasive, the role of endoscopic practices is evolving. Upper and lower endoscopy can be employed for diagnostic purposes, screening and surveillance practices, and for therapeutic interventions. The most frequently applied different indications, tools, and techniques for the various uses of endoscopy will be discussed.

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Boddupelli, Madhusudhan* Charanya Peechara. "Epilepsy: A Review of the Latest Advances in Diagnostic Techniques and Therapeutic Interventions." International Journal of Pharmaceutical Sciences 3, no. 2 (2025): 1724–33. https://doi.org/10.5281/zenodo.14899507.

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Millions of people worldwide suffer from epilepsy, a complicated neurological condition, with many of those patients developing drug-resistant epilepsy.(1)Epilepsy diagnosis and treatment are inextricably linked; proper therapy can only be provided in the absence of an accurate diagnosis. It is uncommon to witness a seizure during the first medical checkup or at an outpatient clinic. As a result, the confirmation and diagnosis of seizure types are typically based mainly on the history obtained from parents or caregivers.(2)The objective of this review is to discuss about the recent development

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Mitry, M. A., S. Strauss, D. Holzwanger, J. L. Chazen, and G. Salama. "Neuroradiology Image-Guided Interventions in Oncologic Disease." Neurographics 13, no. 4 (2023): 287–93. http://dx.doi.org/10.3174/ng.2100049.

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Image-guided interventions in neuroradiology play an integral role in both the diagnosis and treatment of many oncologic conditions. This article reviews the range of image-guided interventions performed by neuroradiology as part of the care team for patients with cancer, with a specific discussion of indications and techniques for diagnostic and therapeutic procedures. These interventions aid in the diagnosis, presurgical planning, and treatment of primary and metastatic diseases in the head, neck, and spine as well as contribute to the management of neuropathic cancer-related pain.Learning O

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Raza, Ali, and Kumar Krishnan. "Endoscopic Pancreato-Biliary Interventions." Digestive Disease Interventions 02, no. 04 (2018): 336–45. http://dx.doi.org/10.1055/s-0038-1675756.

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AbstractEndoscopic ultrasound (EUS) and endoscopic retrograde cholangiopancreatography (ERCP) play a critical role in the diagnosis and management of benign and malignant pancreatobiliary diseases. In the last several years, role of ERCP has evolved from just a diagnostic procedure to mostly a therapeutic procedure. It plays a key role in the diagnosis of indeterminate biliary strictures and evaluation of bile leaks. Therapeutic ERCP utilizes various techniques for the extraction of biliary and pancreatic stones, management of bile leaks, and the treatment of malignant and benign strictures. E

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Hansen, Hans C. "Sacroiliac Joint Interventions: A Systematic Review." Pain Physician 1;10, no. 1;1 (2007): 165–84. http://dx.doi.org/10.36076/ppj.2007/10/165.

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Background: The sacroiliac joint is a diarthrodial synovial joint with abundant innervation and capability of being a source of low back pain and referred pain in the lower extremity. There are no definite historical, physical, or radiological features to provide definite diagnosis of sacroiliac joint pain, although many authors have advocated provocational maneuvers to suggest sacroiliac joint as a pain generator. An accurate diagnosis is made by controlled sacroiliac joint diagnostic blocks. The sacroiliac joint has been shown to be a source of pain in 10% to 27% of suspected cases with chro

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Franzini, Tomazo Antonio Prince, Renata Nobre Moura, and Eduardo Guimarães Hourneaux de Moura. "Advances in Therapeutic Cholangioscopy." Gastroenterology Research and Practice 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/5249152.

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Nowadays, cholangioscopy is an established modality in diagnostic and treatment of pancreaticobiliary diseases. The more widespread use and the recent development of new technologies and accessories had renewed the interest of endoscopic visualization of the biliary tract, increasing the range of indications and therapeutic procedures, such as diagnostic of indeterminate biliary strictures, lithotripsy of difficult bile duct stones, ablative techniques for intraductal malignancies, removal of foreign bodies and gallbladder drainage. These endoscopic interventions will probably be the last fron

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Kapila, Helen, and Nicholas Coni. "The Application of Modern Diagnostic and Therapeutic Techniques to Aged Patients." Ageing and Society 9, no. 2 (1989): 165–77. http://dx.doi.org/10.1017/s0144686x00013544.

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ABSTRACTThe availability of high technology designed to preserve human life, places medical practitioners in a set of ethical dilemmas. In particular the use of Intensive Care Units to sustain acutely seriously ill elderly people is a matter of widespread debate. An examination of the medical research literature suggests that such interventions are largely successful and wished for by the patient, but the quality of surviving life is for some, unacceptable. It is concluded that the maintance of life should remain the predominant rule, but that where patient and clinical judgement indicates it,

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H. C, Chandana, Darshan K. A, Suvarna Yendur, and Naga Prashant Koppuravuri. "Prostate cancer: Diagnosis, Therapeutic Interventions and Emerging Challenges." Oriental Journal Of Chemistry 41, no. 2 (2025): 399–408. https://doi.org/10.13005/ojc/410208.

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Prostate cancer, the second most prevalent malignancy in men worldwide, is a complex disease caused by various factors like genetic, environmental, and hormonal influences. Despite progress in interpreting its pathogenesis, difficulties in reliable diagnosis and effective therapy remain. Present diagnostic instruments, such as prostate-specific antigen (PSA) testing and digital rectal examination (DRE), have limited specificity, frequently leading to overdiagnosis and unwanted biopsies. Novel biomarkers, like PCA3 and multiparametric MRI (mpMRI), have improved diagnostic accuracy, especially i

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Simopoulos, Thomas T. "Systematic Review of the Diagnostic Accuracy and Therapeutic Effectiveness of Sacroiliac Joint Interventions." Pain Physician 5;18, no. 5;9 (2015): E713—E756. http://dx.doi.org/10.36076/ppj.2015/18/e713.

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Background: The sacroiliac joint is well known as a cause of low back and lower extremity pain. Prevalence estimates are 10% to 25% in patients with persistent axial low back pain without disc herniation, discogenic pain, or radiculitis based on multiple diagnostic studies and systematic reviews. However, at present there are no definitive management options for treating sacroiliac joint pain. Objective: To evaluate the diagnostic accuracy and therapeutic effectiveness of sacroiliac joint interventions. Study Design: A systematic review of the diagnostic accuracy and therapeutic effectiveness

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10

Baliss, Michelle, Devan Patel, Mahmoud Y. Madi, and Ahmad Najdat Bazarbashi. "EUS-Guided Vascular Interventions." Journal of Clinical Medicine 12, no. 6 (2023): 2165. http://dx.doi.org/10.3390/jcm12062165.

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Endoscopic ultrasound (EUS) has numerous advanced applications as a diagnostic and therapeutic modality in contemporary medicine. Through intraluminal placement, EUS offers a real-time Doppler-guided endoscopic visualization and access to intra-abdominal vasculature, which were previously inaccessible using historical methods. We aim to provide a comprehensive review of key studies on both current and future EUS-guided vascular applications. This review details EUS-based vascular diagnostic techniques of portal pressure measurements in the prognostication of liver disease and portal venous sam

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Allaqaband, Hassan, David D. Gutterman, and Andrew O. Kadlec. "Physiological Consequences of Coronary Arteriolar Dysfunction and Its Influence on Cardiovascular Disease." Physiology 33, no. 5 (2018): 338–47. http://dx.doi.org/10.1152/physiol.00019.2018.

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To date, the major focus of diagnostic modalities and interventions to treat coronary artery disease has been the large epicardial vessels. Despite substantial data showing that microcirculatory dysfunction is a strong predictor of future adverse cardiovascular events, very little research has gone into developing techniques for in vivo diagnosis and therapeutic interventions to improve microcirculatory function. In this review, we will discuss the pathophysiology of coronary arteriolar dysfunction, define its prognostic implications, evaluate the diagnostic modalities available, and provide s

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Lassola, Sergio, Francesco Cundari, Giuseppe Marini, Francesco Corradi, and Silvia De Rosa. "Advancements in Trauma-Induced Acute Kidney Injury: Diagnostic and Therapeutic Innovations." Life 14, no. 8 (2024): 1005. http://dx.doi.org/10.3390/life14081005.

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Acute kidney injury following trauma impacts patient recovery critically, necessitating an integrated approach to emergency care and nephrology. This review aims to provide a comprehensive understanding of trauma-induced nephropathy, highlighting recent advancements in pathophysiological insights, diagnostic techniques, and strategic interventions. Our key findings emphasize the role of biomarkers, like Neutrophil Gelatinase-Associated Lipocalin and Liver Fatty Acid-Binding Protein, and imaging techniques, such as contrast-enhanced ultrasound, in early AKI detection. Preventive strategies, inc

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Khan, Haidar, Sharon Slomovich, Neal C. Shah, and Frank Gress. "Interventional Endoscopic Ultrasonography: Advances in Application." Journal of Clinical Medicine 14, no. 10 (2025): 3286. https://doi.org/10.3390/jcm14103286.

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Technological advances have greatly expanded the diagnostic and therapeutic capabilities of endoscopic ultrasound (EUS). The integration of cutting-edge imaging techniques, including tissue harmonic echo, contrast-enhanced harmonic EUS, elastography, and needle-based confocal laser endomicroscopy, have significantly enhanced lesion characterization and diagnostic accuracy. Additionally, developments in stent design and the introduction of new accessories have broadened the therapeutic applications of EUS. Ongoing innovations in clinical practice have transformed procedures such as drainage, tu

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Sharma, Aniketa. "Advancements in Therapeutic and Diagnostic Strategies for COVID-19: A Review of Recent Developments." Acta Pharma Reports 2, no. 2 (2023): 20–24. http://dx.doi.org/10.51470/apr.2023.2.2.20.

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The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has challenged healthcare systems worldwide, necessitating rapid advancements in therapeutic and diagnostic strategies. This review examines recent developments in the management of COVID-19, focusing on emerging treatments and diagnostic modalities. Therapeutic interventions, including antiviral agents, immunomodulators, monoclonal antibodies, and repurposed drugs, are evaluated for their mechanisms of action and clinical efficacy. Additionally, novel diagnostic techniques such as molecular testing, antigen detection assays, s

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Kashtalian, M., O. Herasymenko, Ya Haida, P. Shkliarevych, D. Atanasov, and A. Okolets. "Fast examination and interventional ultrasound in the diagnosis and treatment of combat abdominal trauma." Journal of Education, Health and Sport 50, no. 1 (2023): 147–52. http://dx.doi.org/10.12775/jehs.2023.50.01.011.

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To improve the diagnosis and surgical treatment of wounded patients with combat abdominal trauma by methods of emergency ultrasound diagnostics and minimally invasive surgery under the control of ultrasound. The purpose of the work is to improve the results of diagnosis and surgical treatment of wounded patients with combat abdominal trauma by emergency ultrasound examination techniques and minimally invasive surgical interventions under ultrasound control. A clinical and statistical analysis of the results of the surgical treatment of 293 wounded patients with combat abdominal trauma treated

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Atluri, Sairam. "Systematic Review of Diagnostic Utility and Therapeutic Effectiveness of Thoracic Facet Joint Interventions." October 2008 5;11, no. 10;5 (2008): 611–29. http://dx.doi.org/10.36076/ppj.2008/11/611.

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Background: Chronic mid back and upper back pain caused by thoracic facet joints has been reported in 34% to 48% of the patients based on the responses to controlled diagnostic blocks. Systematic reviews have established moderate evidence for controlled comparative local anesthetic blocks of thoracic facet joints in the diagnosis of mid back and upper back pain, moderate evidence for therapeutic thoracic medial branch blocks, and limited evidence for radiofrequency neurotomy of therapeutic facet joint nerves. Objectives: To determine the clinical utility of diagnostic and therapeutic thoracic

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Salimi, Mohammadhossein, Majid Roshanfar, Nima Tabatabaei, and Bobak Mosadegh. "Machine Learning-Assisted Short-Wave InfraRed (SWIR) Techniques for Biomedical Applications: Towards Personalized Medicine." Journal of Personalized Medicine 14, no. 1 (2023): 33. http://dx.doi.org/10.3390/jpm14010033.

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Personalized medicine transforms healthcare by adapting interventions to individuals’ unique genetic, molecular, and clinical profiles. To maximize diagnostic and/or therapeutic efficacy, personalized medicine requires advanced imaging devices and sensors for accurate assessment and monitoring of individual patient conditions or responses to therapeutics. In the field of biomedical optics, short-wave infrared (SWIR) techniques offer an array of capabilities that hold promise to significantly enhance diagnostics, imaging, and therapeutic interventions. SWIR techniques provide in vivo informatio

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18

Frohman, E. M., P. D. Kramer, R. B. Dewey, L. Kramer, and T. C. Frohman. "Benign paroxysmal positioning vertigo in multiple sclerosis: diagnosis, pathophysiology and therapeutic techniques." Multiple Sclerosis Journal 9, no. 3 (2003): 250–55. http://dx.doi.org/10.1191/1352458503ms901oa.

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Objective: To report on the most common causes of vertigo in patients with multiple sclerosis (MS) and emphasize appro priate diagnostic techniques and treatment interventions. Background: True vertigo is estimated to occur in about 20% of MS patients. Lesions within the vestibular nuclei and in the root entry zone of cranial nerve VIII represent the most common locations where demyelinating activity can provoke vertigo in patients with MS. However, other causes of vertigo should be explored in MS patients in order to avoid unnecessar y treatment with corticosteroids and vestibular suppressant

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Sushma, Vikas Kumar Srivastava. "Alzheimer's Disease: Emerging Therapies, Diagnostic Innovations, and Future Prospects." International Journal of Pharmaceutical Sciences 2, no. 8 (2024): 3420–27. https://doi.org/10.5281/zenodo.13338145.

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Alzheimer's disease (AD) remains one of the most challenging neurodegenerative disorders, affecting millions worldwide. Despite significant advances in understanding its pathology, effective treatment and early diagnosis remain elusive. This review explores the latest therapeutic approaches, including targeted drug therapies, immunotherapies, and novel interventions like gene editing and neurostimulation. Additionally, the review delves into emerging diagnostic tools, such as advanced imaging techniques, biomarkers, and AI-driven diagnostics, which are pushing the boundaries of early detection

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20

Datta, Sukdeb. "Systematic Assessment of Diagnostic Accuracy and Therapeutic Utility of Lumbar Facet Joint Interventions." Pain Physician 2;12, no. 2;3 (2009): 437–60. http://dx.doi.org/10.36076/ppj.2009/12/437.

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Background: Lumbar facet joints are a well recognized source of low back pain and referred pain in the lower extremity in patients with chronic low back pain. Conventional clinical features and other non-invasive diagnostic modalities are unreliable in diagnosing lumbar zygapophysial joint pain. Controlled diagnostic studies have shown the prevalence of lumbar facet joint pain in 27% to 40% of the patients with chronic low back pain without disc displacement or radiculitis, with a false-positive rate of 27% to 47% with a single diagnostic block. Study Design: A systematic review of diagnostic

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Manchikanti, Laxmaiah. "Comprehensive Evidence-Based Guidelines for Interventional Techniques in the Management of Chronic Spinal Pain." Pain Physician 4;12, no. 4;7 (2009): 699–802. http://dx.doi.org/10.36076/ppj.2009/12/699.

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Background: Comprehensive, evidence-based guidelines for interventional techniques in the management of chronic spinal pain are described here to provide recommendations for clinicians. Objective: To develop evidence-based clinical practice guidelines for interventional techniques in the diagnosis and treatment of chronic spinal pain. Design: Systematic assessment of the literature. Methods: Strength of evidence was assessed by the U.S. Preventive Services Task Force (USPSTF) criteria utilizing 5 levels of evidence ranging from Level I to III with 3 subcategories in Level II. Outcomes: Short-t

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Huynh, Quy-Susan, Shalini Elangovan, and R. M. Damian Holsinger. "Non-Pharmacological Therapeutic Options for the Treatment of Alzheimer’s Disease." International Journal of Molecular Sciences 23, no. 19 (2022): 11037. http://dx.doi.org/10.3390/ijms231911037.

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Alzheimer’s disease is a growing global crisis in need of urgent diagnostic and therapeutic strategies. The current treatment strategy mostly involves immunotherapeutic medications that have had little success in halting disease progress. Hypotheses for pathogenesis and development of AD have been expanded to implicate both organ systems as well as cellular reactions. Non-pharmacologic interventions ranging from minimally to deeply invasive have attempted to address these diverse contributors to AD. In this review, we aim to delineate mechanisms underlying such interventions while attempting t

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César, Hayashi-Mercado, González-Urueta Miguel, Luna-López Gabriel, González Gallo Oscar, and Aguilar Abelardo. "Pseudoaneurysms in Peripheral Vasculature Following a Percutaneous Intervention, Different Diagnostic Approaches: Case Reports." INTERNATIONAL JOURNAL OF MEDICAL SCIENCE AND CLINICAL RESEARCH STUDIES 03, no. 09 (2023): 2002–6. https://doi.org/10.5281/zenodo.8371667.

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Pseudoaneurysm is defined as a vascular anomaly generated by the interruption of the arterial wall, which conditions accumulation and persistent confinement of blood. The incidence of pseudoaneurysm ranges between 0.2%-0.5% in diagnostic interventional techniques and up to 6% in therapeutic techniques, however, despite its low incidence, complications are potentially severe. We present 3 cases of pseudoaneurysm in the peripheral vasculature after percutaneous interventions, as well as the description of the diagnostic challenge and the assessment by the different imaging methods.   This c

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Parikh, S. S., F. S. Kavani, K. H. Parmar, et al. "Diagnostic and therapeutic management of subclinical endometritis in dairy bovine: A Review." Animal Reproduction Update 2, no. 2 (2022): 1–11. http://dx.doi.org/10.48165/aru.2022.2.2.1.

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Subclinical endometritis (SCE) is one of the major causes of repeat breeding syndrome in dairy bovines, characterized by the presence of polymorpho nuclear (PMN) cells within uterine cytology sample during early postpartum period. In dairy bovines, on an average 20-53 % animals suffer from SCE between 20 and 60 days post-calving due to variable risk factors. Among various diagnostic techniques, cytotape method of sample collection is comparatively superior to cytobrush and other techniques for early diagnosis of SCE in dairy bovine. A variable result of conventional therapy for successful mana

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Buhari, Hauwa Ali, Aisha Sa’ad Ahmad, and Emmanuel Ifeanyi Obeagu. "Current Advances in the Diagnosis and Treatment of Sickle Cell Anaemia." NEWPORT INTERNATIONAL JOURNAL OF BIOLOGICAL AND APPLIED SCIENCES 4, no. 1 (2023): 1–10. http://dx.doi.org/10.59298/nijbas/2023/1.1.11111.

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Sickle cell anemia (SCA) presents a complex challenge globally due to its significant morbidity and mortality. Recent advancements in diagnostic tools and treatment modalities have revolutionized the management of this hereditary hemoglobin disorder. This paper aims to synthesize current breakthroughs in the diagnosis and treatment of sickle cell anemia. Diagnostic techniques including genetic testing, hemoglobin electrophoresis, and advanced imaging methodologies are explored, providing insights into their accuracy and clinical applicability. Moreover, novel therapeutic approaches such as gen

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Filippiadis, Dimitrios K., Salvatore Masala, Pierleone Lucatelli, and Alexis Kelekis. "Update on Interventional Radiology of the Spine." Seminars in Musculoskeletal Radiology 26, no. 04 (2022): 412–23. http://dx.doi.org/10.1055/s-0042-1748913.

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AbstractInterventional radiologists now perform spinal interventions routinely for diagnostic and therapeutic purposes. New technologies for the management of spine pathologies have emerged with promising results in terms of safety and efficacy. Interventional radiology techniques in the spine include percutaneous biopsy and therapies for intervertebral disk herniation or spinal stenosis, facet and sacroiliac joint pathologies, vertebral and sacral fractures, and metastases. These techniques can also be easily combined one with the other or to further therapeutic approaches including systemic

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27

Geaghan, Sharon M. "Fetal Laboratory Medicine: On the Frontier of Maternal–Fetal Medicine." Clinical Chemistry 58, no. 2 (2012): 337–52. http://dx.doi.org/10.1373/clinchem.2011.166991.

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Abstract BACKGROUND Emerging antenatal interventions and care delivery to the fetus require diagnostic support, including laboratory technologies, appropriate methodologies, establishment of special algorithms, and interpretative guidelines for clinical decision-making. CONTENT Fetal diagnostic and therapeutic interventions vary in invasiveness and are associated with a spectrum of risks and benefits. Fetal laboratory assessments are well served by miniaturized diagnostic methods for blood analysis. Expedited turnaround times are mandatory to support invasive interventions such as cordocentesi

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Johnrose, Dr Densingh, Mihir Sharma, Azaruddin Gohil, and Shivam Singh. "Molecular Diagnostics and Therapeutic Approaches in Zoonotic Infections." International Journal of Research and Innovation in Applied Science X, no. VI (2025): 694–706. https://doi.org/10.51584/ijrias.2025.10060054.

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Zoonotic infections—diseases naturally transmitted between animals and humans—represent over 60% of emerging infectious diseases globally. The increasing frequency of zoonotic outbreaks, driven by factors such as globalization, environmental change, and intensified human–animal interactions, underscores the urgent need for robust diagnostic and therapeutic strategies. Traditional diagnostic tools, while useful, often lack the sensitivity, specificity, and speed required to manage emerging zoonoses effectively. In response, molecular diagnostics have revolutionized the detection and characteriz

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Manchikanti, Laxmaiah. "An Algorithmic Approach for Clinical Management of Chronic Spinal Pain." Pain Physician 4;12, no. 4;7 (2009): E225—E264. http://dx.doi.org/10.36076/ppj.2009/12/e264.

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Interventional pain management, and the interventional techniques which are an integral part of that specialty, are subject to widely varying definitions and practices. How interventional techniques are applied by various specialties is highly variable, even for the most common procedures and conditions. At the same time, many payors, publications, and guidelines are showing increasing interest in the performance and costs of interventional techniques. There is a lack of consensus among interventional pain management specialists with regards to how to diagnose and manage spinal pain and the ty

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Shuxrat Toshtemirovich, Niyozov, Mamurova Mavludaxon Mirxamzayevna, and Turayev Bobir Temirpulotovich. "MODERN METHODS OF DIAGNOSING AND TREATING NEUROLOGICAL CHANGES OBSERVED IN ALCOHOLISM." Journal of Medical Genetics and Clinical Biology 2, no. 1 (2025): 107–16. https://doi.org/10.61796/jmgcb.v2i1.1203.

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Objective: This study aims to explore modern methods of diagnosing and treating neurological changes associated with alcoholism, with a focus on understanding the pathological mechanisms underlying alcohol dependence and its impact on the nervous system. Method: A systematic review of recent clinical studies, diagnostic criteria from DSM-5, and neuroimaging techniques was conducted to evaluate current diagnostic tools and therapeutic approaches. The analysis included neuropsychological assessments, biomarker identification, and pharmacological interventions targeting alcohol-induced neurologic

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Sushma*1, Vikas Kumar Srivastava2. "Alzheimer's Disease: Emerging Therapies, Diagnostic Innovations, and Future Prospects." International Journal in Pharmaceutical Sciences 2, no. 8 (2024): 3437–44. https://doi.org/10.5281/zenodo.13346603.

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Alzheimer's disease (AD) remains one of the most challenging neurodegenerative disorders, affecting millions worldwide. Despite significant advances in understanding its pathology, effective treatment and early diagnosis remain elusive. This review explores the latest therapeutic approaches, including targeted drug therapies, immunotherapies, and novel interventions like gene editing and neurostimulation. Additionally, the review delves into emerging diagnostic tools, such as advanced imaging techniques, biomarkers, and AI-driven diagnostics, which are pushing the boundaries of early detection

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Falco, Frank. "Systematic Review of Diagnostic Utility and Therapeutic Effectiveness of Cervical Facet Joint Interventions." Pain Physician 2;12, no. 2;3 (2009): 323–44. http://dx.doi.org/10.36076/ppj.2009/12/323.

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Background: Chronic, recurrent neck pain is common and is associated with high pain intensity and disability, which is seen in 14% of the adult general population. Controlled studies have supported the existence of cervical facet or zygapophysial joint pain in 36% to 67% of these patients. However, these studies also have shown false-positive results in 27% to 63% of the patients with a single diagnostic block. There is also a paucity of literature investigating therapeutic interventions of cervical facet joint pain. Study Design: A systematic review of cervical facet joint interventions. Obje

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Jee, Sohan, Bhagyesh Sapkale, Dhruba Chandi, and Anup Thakare. "A review on achromatopsia: Exploring genetic basis, diagnostic innovations, and therapeutic prospects." Multidisciplinary Reviews 8, no. 2 (2024): 2025058. http://dx.doi.org/10.31893/multirev.2025058.

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Achromatopsia (ACHM) is a rare inherited retinal disorder characterized by partial or complete color blindness, which impacts individuals' quality of life and daily functioning. This review delves into the genetic basis, diagnostic innovations, and therapeutic prospects associated with ACHM. The main objective is to comprehensively explore the current understanding of ACHM, including genetic mutations, diagnostic techniques, and management approaches, while also discussing potential therapeutic interventions. Achromatopsia primarily results from mutations in genes encoding cone photoreceptor p

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ASIPP, ASIPP. "An Update of Comprehensive Evidence-Based Guidelines for Interventional Techniques in Chronic Spinal Pain. Part II: Guidance and Recommendations." Pain Physician 2s;16, no. 2s;4 (2013): S49—S283. http://dx.doi.org/10.36076/ppj.2013/16/s49.

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Objective: To develop evidence-based clinical practice guidelines for interventional techniques in the diagnosis and treatment of chronic spinal pain. Methodology: Systematic assessment of the literature. Evidence: I. Lumbar Spine • The evidence for accuracy of diagnostic selective nerve root blocks is limited; whereas for lumbar provocation discography, it is fair. • The evidence for diagnostic lumbar facet joint nerve blocks and diagnostic sacroiliac intraarticular injections is good with 75% to 100% pain relief as criterion standard with controlled local anesthetic or placebo blocks. • The

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Siddharth, Jain, Gupta Mayank, Agarwal Madhulata, and Jain Poonam. "Advances in Diabetic Retinopathy: Pioneering Technologies Transforming Patient Care." International Journal of Pharmaceutical and Clinical Research 16, no. 9 (2024): 850–54. https://doi.org/10.5281/zenodo.13909403.

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<strong>Background: </strong>Diabetic retinopathy (DR) is a leading cause of vision impairment among working-age adults globally. Recent technological advancements offer promising improvements in the diagnosis and management of DR. <strong>Objective:</strong> To evaluate the efficacy of advanced imaging techniques, novel therapeutic agents, and telemedicine services in transforming patient care for diabetic retinopathy. <strong>Methods:</strong> A randomized controlled trial was conducted with 200 patients diagnosed with non-proliferative diabetic retinopathy. Particip

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Elsayed Shaheen, Mashael Sultan Alsadoon, Muath Mohammed S. Almuqhim, et al. "Surgical Management of Lumbar Spine Fractures and Dislocations." Journal of Advanced Zoology 44, S-3 (2023): 1456–61. http://dx.doi.org/10.17762/jaz.v44is-3.1774.

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Background: Lumbar spine fractures and dislocations, which are part of the thoracolumbar region, are critical injuries with significant morbidity. The epidemiological shift in the median age of injury and the high prevalence of these injuries, particularly in the T10-L2 region, highlight the necessity for effective therapeutic interventions. With advancements in spine biomechanics, imaging technologies, and surgical techniques, there has been a paradigm shift from conservative to surgical management, though high-quality comparative studies remain limited. Objective: To synthesize recent data o

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Diego, Alejandro Ramírez López, Lorena Martínez Martínez Adriana, Manuel Garcia huerta Juan, Sarahí Gonzales Escareño Noemí, Paulina Flores de la Rosa Ana, and Natalia Flores Vargas Emily. "Emerging Trends in Glaucoma Management: Advancements in Diagnostic Modalities, Therapeutic Interventions, and Personalized Medicine Approaches." International Journal of Medical Science and Clinical Research Studies 5, no. 05 (2025): 679–85. https://doi.org/10.5281/zenodo.15347863.

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Glaucoma, a progressive optic neuropathy characterized by retinal ganglion cell degeneration and visual field loss, remains a leading cause of irreversible blindness worldwide. Recent advancements in imaging technologies, minimally invasive surgical techniques (MIGS), and neuroprotective therapies have revolutionized the diagnostic and therapeutic landscape of this multifactorial disease. This article explores contemporary trends in glaucoma care, including the integration of artificial intelligence (AI) in optical coherence tomography (OCT) analysis, the role of biomarkers in early detection,

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Donaldo, Emiliano Silva López, Verónica Hernández González Danna, Valdos Rodríguez Karla, Nieves Vázquez Geraldine, Elías Galicia García Luis, and Manuel Dorado Ramírez John. "Spontaneous Coronary Artery Dissection and Tear Repair: A Comprehensive Review of Pathophysiology, Diagnosis, and Therapeutic Interventions." International Journal of Medical Science and Clinical Research Studies 04, no. 06 (2024): 1190–97. https://doi.org/10.5281/zenodo.12234537.

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Spontaneous Coronary Artery Dissection (SCAD) represents a rare but significant cause of acute coronary syndrome, predominantly affecting young to middle-aged women without traditional cardiovascular risk factors. The pathophysiology of SCAD involves the spontaneous development of an intimal tear or the formation of an intramural hematoma, leading to coronary artery obstruction and myocardial ischemia. Diagnosing SCAD is challenging due to its varied presentation and the need for high-resolution imaging techniques. Management strategies for SCAD are diverse, ranging from conservative medical t

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Chang, Yijin, Jiahao Lu, and Changsheng Chen. "Biomarkers in Venous Thrombosis: Diagnostic Potential and Limitations." Biology 14, no. 7 (2025): 800. https://doi.org/10.3390/biology14070800.

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Venous thromboembolism (VTE), comprising deep vein thrombosis (DVT) and pulmonary embolism (PE), is a life-threatening vascular disorder associated with significant morbidity and mortality. Prompt diagnosis is crucial for preventing fatal complications. Current clinical VTE diagnosis predominantly relies on imaging modalities such as compression ultrasound, computed tomography angiography (CTA), and magnetic resonance imaging (MRI). However, these techniques are resource-intensive, time-consuming, and may expose patients to radiation risks. Consequently, the development of highly sensitive and

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Hecken, Julia M., Günther A. Rezniczek, and Clemens B. Tempfer. "Innovative Diagnostic and Therapeutic Interventions in Cervical Dysplasia: A Systematic Review of Controlled Trials." Cancers 14, no. 11 (2022): 2670. http://dx.doi.org/10.3390/cancers14112670.

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Cervical dysplasia is a common precancerous lesion affecting 1% to 2% of women worldwide. Significant progress in the diagnosis and treatment of cervical dysplasia have been made in the last decade. We performed a systematic literature search of the databases PubMed and Cochrane Central Register of Controlled Trials to identify controlled clinical trials reporting on the efficacy and safety of diagnostic and therapeutic interventions for cervical dysplasia. Data were analyzed according to PRISMA guidelines. In total, 33 studies reporting on 5935 women were identified. We recommend intravenous

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Almuhaidb, Aymen, Dylan Olson, and A. Aziz Aadam. "Advancements in Endoscopic Biliary Interventions by Gastroenterology." Seminars in Interventional Radiology 38, no. 03 (2021): 280–90. http://dx.doi.org/10.1055/s-0041-1731266.

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AbstractEndoscopic retrograde cholangiopancreatography (ERCP) is an endoscopic technique in which a specialized side-viewing endoscope is guided into the duodenum, allowing for instruments to access the biliary and pancreatic ducts. ERCP was initially developed as a diagnostic tool as computed tomography was in its infancy during that time. ERCP has evolved since its inception in the 1960s to becoming not only a valuable diagnostic resource but now an effective therapeutic intervention in the treatment of various biliary disorders. The most common biliary interventions performed by ERCP includ

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Mahmoud, Ahmed M., Amr Moustafa, Carter Day, et al. "Prostate Cancer Lung Metastasis: Clinical Insights and Therapeutic Strategies." Cancers 16, no. 11 (2024): 2080. http://dx.doi.org/10.3390/cancers16112080.

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Prostate cancer lung metastasis represents a clinical conundrum due to its implications for advanced disease progression and the complexities it introduces in treatment planning. As the disease progresses to distant sites such as the lung, the clinical management becomes increasingly intricate, requiring tailored therapeutic strategies to address the unique characteristics of metastatic lesions. This review seeks to synthesize the current state of knowledge surrounding prostate cancer metastasis to the lung, shedding light on the diverse array of clinical presentations encountered, ranging fro

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Tang, Yiqun, Caroline Frisendahl, Parameswaran Grace Lalitkumar, and Kristina Gemzell-Danielsson. "An Update on Experimental Therapeutic Strategies for Thin Endometrium." Endocrines 4, no. 4 (2023): 672–84. http://dx.doi.org/10.3390/endocrines4040048.

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Infertility caused by a thin endometrium remains a significant challenge in assisted reproduction and is often associated with a low success rate after treatment with assisted reproductive technology. There is a lack of consensus in the field concerning both its diagnostic criteria and clinical management. The currently available treatment options are few with limited efficacy. Recent advances in cell therapy and bioengineering have, however, shown promising results for the treatment of a thin endometrium. Notably, these novel interventions have demonstrated the ability to increase endometrial

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Thenuwara, Gayathree, James Curtin, and Furong Tian. "Advances in Diagnostic Tools and Therapeutic Approaches for Gliomas: A Comprehensive Review." Sensors 23, no. 24 (2023): 9842. http://dx.doi.org/10.3390/s23249842.

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Gliomas, a prevalent category of primary malignant brain tumors, pose formidable clinical challenges due to their invasive nature and limited treatment options. The current therapeutic landscape for gliomas is constrained by a “one-size-fits-all” paradigm, significantly restricting treatment efficacy. Despite the implementation of multimodal therapeutic strategies, survival rates remain disheartening. The conventional treatment approach, involving surgical resection, radiation, and chemotherapy, grapples with substantial limitations, particularly in addressing the invasive nature of gliomas. C

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Sartori-Valinotti, Julio C., Megha M. Tollefson, and Ann M. Reed. "Updates on Morphea: Role of Vascular Injury and Advances in Treatment." Autoimmune Diseases 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/467808.

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Morphea and systemic sclerosis are fibrosing disorders of the skin that share common inflammatory and immunologic pathways that are responsible for the vascular changes, increased collagen production, and extracellular matrix proliferation seen in both conditions. Recent advances in molecular biology techniques have furthered our knowledge of the potential underlying pathogenic mechanisms and offer new and provocative areas of research for novel diagnostic and therapeutic interventions. This review focuses on the role of vascular injury in the development of morphea, the use of ultrasonography

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Maksymenko, M. V., Y. M. Susak, M. V. Korotia, V. V. Volkovetsky, and R. O. Havryliuk. "Standards for providing emergency care at the prehospital and early hospital stages for patients with mechanical jaundice." EMERGENCY MEDICINE 20, no. 2 (2024): 137–43. http://dx.doi.org/10.22141/2224-0586.20.2.2024.1677.

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Mechanical jaundice is a condition characterized by obstructive disorders in the biliary system, posing a diagnostic challenge that requires advanced visualization techniques and laboratory tests for accurate diagnosis. This article explores the role of biochemical markers, presents an analysis of the algorithm for laboratory diagnosis and visualization techniques in order to stratify patients with jaundice syndrome, and conduct timely and effective conservative treatment with further surgical interventions. A comprehensive diagnostic and therapeutic algorithm has been developed whose use by e

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Manchikanti, Laxmaiah. "Comprehensive Evidence-Based Guidelines for Facet Joint Interventions in the Management of Chronic Spinal Pain: American Society of Interventional Pain Physicians (ASIPP) Guidelines." Pain Physician 3S;23, no. 5;3S (2020): S1—S127. http://dx.doi.org/10.36076/ppj.2020/23/s1.

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Background: Chronic axial spinal pain is one of the major causes of significant disability and health care costs, with facet joints as one of the proven causes of pain. Objective: To provide evidence-based guidance in performing diagnostic and therapeutic facet joint interventions. Methods: The methodology utilized included the development of objectives and key questions with utilization of trustworthy standards. The literature pertaining to all aspects of facet joint interventions, was reviewed, with a best evidence synthesis of available literature and utilizing grading for recommendations.

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ASIPP, ASIPP. "Interventional Techniques: Evidence-based Practice Guidelines in the Management of Chronic Spinal Pain." Pain Physician 1;10, no. 1;1 (2007): 7–111. http://dx.doi.org/10.36076/ppj.2007/10/7.

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Background: The evidence-based practice guidelines for the management of chronic spinal pain with interventional techniques were developed to provide recommendations to clinicians in the United States. Objective: To develop evidence-based clinical practice guidelines for interventional techniques in the diagnosis and treatment of chronic spinal pain, utilizing all types of evidence and to apply an evidence-based approach, with broad representation by specialists from academic and clinical practices. Design: Study design consisted of formulation of essentials of guidelines and a series of poten

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Himmelsbach, Anika, Carina Ciliox, and Claudia Goettsch. "Cardiovascular Calcification in Chronic Kidney Disease—Therapeutic Opportunities." Toxins 12, no. 3 (2020): 181. http://dx.doi.org/10.3390/toxins12030181.

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Patients with chronic kidney disease (CKD) are highly susceptible to cardiovascular (CV) complications, thus suffering from clinical manifestations such as heart failure and stroke. CV calcification greatly contributes to the increased CV risk in CKD patients. However, no clinically viable therapies towards treatment and prevention of CV calcification or early biomarkers have been approved to date, which is largely attributed to the asymptomatic progression of calcification and the dearth of high-resolution imaging techniques to detect early calcification prior to the ‘point of no return’. Cle

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Ethel, Jenny García Cruz, Ibrahim Hernández Solis Eduardo, Karelia Rivera Nájera Sayra, Alejandro Razo Ocegueda Oscar, and Grande García Ricardo. "Meckel's Diverticulum: An In-depth Review of Pathophysiology, Clinical Presentation, Diagnostic Modalities, and Therapeutic Interventions." International Journal of Medical Science and Clinical Research Studies 04, no. 08 (2024): 1468–72. https://doi.org/10.5281/zenodo.13304509.

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<strong>Background:</strong> Meckel's diverticulum is the most prevalent congenital anomaly of the gastrointestinal tract, resulting from the incomplete obliteration of the omphalomesenteric duct during fetal development. Although often asymptomatic, it can present with a variety of complications, including bleeding, obstruction, and inflammation, necessitating timely and accurate diagnosis and intervention.   <strong>Objective:</strong> This article aims to provide a comprehensive overview of Meckel's diverticulum, including its embryological origin, pathophysiological features

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