Log in

Relevant bibliographies by topics / Diagnostický marker / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Diagnostický marker.

Dissertations / Theses on the topic 'Diagnostický marker'

Author: Grafiati

Published: 4 June 2021

Last updated: 16 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Diagnostický marker.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Schmiemann, Viola. "Methylierung als molekularbiologischer Marker zur Lungenkarzinom-Diagnostik." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=976445581.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Satterthwaite, Gemma. "Discovery of diagnostic markers for atherosclerosis." Thesis, University of Sheffield, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274961.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Admiraal, Claudia Johanna. "Eosinophil degranulation as an allergy activation marker." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2001. http://dare.uva.nl/document/59048.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Lamp, Ole. "Etablierung biochemischer Marker für Diagnostik und Prognose caniner Mammatumore." Doctoral thesis, Universitätsbibliothek Leipzig, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-87999.

Full text

Abstract:

Canine Mammatumoren (CMT) sind eine der häufigsten Todesursachen bei Hündinnen (SIMON et al. 2001). Durch ihre periphere Lage sind zumeist nicht die Primärtumoren, sondern ihre Metastasen lebensbedrohlich, da diese häufig wichtige Organe wie Lunge Herz und Gehirn befallen (CLEMENTE et al. 2010). Aktuell angewandte Untersuchungsmethoden zur Erkennung von Metastasierung können entweder das invasive Wachstum beschreiben oder bereits bestehende Metastasen detektieren, jedoch fehlen bislang molekulare Marker, die frühzeitig und zuverlässig das metastatische Potential eines CMT anzeigen bevor Metast

APA, Harvard, Vancouver, ISO, and other styles

5

Clark, Rachael Louise. "Diagnostic markers of infection, in chronic wounds." Thesis, Cardiff University, 2007. http://orca.cf.ac.uk/55725/.

Full text

Abstract:

A complication associated with wound healing is wound infection. The diagnosis of infection in chronic wounds can be a difficult clinical decision. Signs and symptoms used to diagnose infection can often be masked by factors relating to the host, chronic inflammation and the tissue damage, associated with chronic wounds. This Study aimed to determine whether there is a measurable biochemical host response that could serve as potential biomarkers of chronic wound infection, providing an alternative diagnostic tool to aid the Clinician. An in vitro model further investigated the expression of ma

APA, Harvard, Vancouver, ISO, and other styles

6

Křůmal, Kamil. "Analýza organických markerů pro identifikaci zdrojů atmosférických aerosolů." Doctoral thesis, Vysoké učení technické v Brně. Fakulta chemická, 2011. http://www.nusl.cz/ntk/nusl-233323.

Full text

Abstract:

In this work the organic markers that serve for identification of sources of aerosols are monitored. Theoretic part deals with detailed survey of organic markers emitted from the most significant sources of atmospheric aerosols (biomass combustion, combustion of fossil fuels and traffic) as well as with sampling of aerosols and analysis of organic markers by analytical techniques. Monosaccharide anhydrides (emissions from biomass combustion) and polyaromatic hydrocarbons (emissions from traffic and incomplete combustion) were observed especially. Hopanes and steranes (traffic, coal combustion)

APA, Harvard, Vancouver, ISO, and other styles

7

Vicente, dos Santos Victor. "Etude des relations phylogénétiques entre les genres de Phytoseiidae (Acari Mesostigmata) et implications pour la lutte biologique." Thesis, Montpellier, SupAgro, 2017. http://www.theses.fr/2017NSAM0009/document.

Full text

Abstract:

Cette thèse porte sur la taxonomie des acariens prédateurs de la famille des Phytoseiidae, dont certaines espèces sont utilisées en lutte biologique pour contrôler des acariens ravageurs et quelques petites espèces d’insectes. La taxonomie de ces organismes de petite taille (<500 μm), i.e. identification spécifique et relations entre les taxa, est essentiellement basée sur des caractères morphologiques. Ces caractères parfois difficiles à visualiser, à interpréter (variations intra et inter-taxa, analogies) et en faible nombre rendent l’identification des espèces et la classification actuel

APA, Harvard, Vancouver, ISO, and other styles

8

Andreasen, Niels. "Search for reliable diagnostic markers for Alzheimer's disease /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4039-8/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Kleine, Albert Hans. "Fatty acid-binding protein as diagnostic marker of acute myocardial infarction in man." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1993. http://arno.unimaas.nl/show.cgi?fid=5939.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Lamp, Ole [Verfasser], Almuth [Akademischer Betreuer] Einspanier, Almuth [Gutachter] Einspanier, and Claudia [Gutachter] Binder. "Etablierung biochemischer Marker für Diagnostik und Prognose caniner Mammatumore : Etablierung biochemischer Marker für Diagnostik und Prognosecaniner Mammatumore / Ole Lamp ; Gutachter: Almuth Einspanier, Claudia Binder ; Betreuer: Almuth Einspanier." Leipzig : Universitätsbibliothek Leipzig, 2012. http://d-nb.info/1238076823/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Essack, Magbubah. "Transcription Regulation and Candidate Diagnostic Markers of Esophageal Cancer." Thesis, University of the Western Cape, 2009. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_5306_1267148426.

Full text

Abstract:

<p>This thesis reports on the development of a novel comprehensive database (Dragon Database of Genes Implicated in Esophageal Cancer, DDEC) as an integrated knowledge database aimed at representing a gateway to esophageal cancer related data. More importantly, it illustrates how the biocurated genes in the database may represent a reliable starting point for divulging transcriptional regulation, diagnostic markers and the biology related to esophageal cancer.</p>

APA, Harvard, Vancouver, ISO, and other styles

12

Al-Khalili, Faris. "Coronary heart disease in women : diagnostic and prognostic markers /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4092-4/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Benazir, Katarina Marquez. "Molecular Marker Applications in Oat (Avena Sativa L.) Breeding and Germplasm Diagnostics." Thèse, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31148.

Full text

Abstract:

The ability to identify germplasm and select traits accurately is fundamental to successful plant breeding. Pedigrees and molecular markers facilitate these processes; however misleading experimental results can occur when incorrect relationships and/or cultivar names are recorded. Molecular markers can identify these inconsistencies, and with advances in genotyping technology these diagnostics can be done faster and more objectively. This study aimed to develop molecular marker assays and graphical genotyping methodologies for cultivar identification, seed purity assessment and trait selectio

APA, Harvard, Vancouver, ISO, and other styles

14

Zheng, Yingye. "Semiparametric methods for longitudinal diagnostic accuracy /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/9580.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Alegre, Melissa Marie. "Thymidine Kinase 1: Diagnostic and Prognostic Significance in Malignancy." BYU ScholarsArchive, 2013. https://scholarsarchive.byu.edu/etd/4049.

Full text

Abstract:

Thymidine kinase 1 (TK1) is a cancer biomarker which has diagnostic and prognostic potential in a variety of malignancies. TK1 is significantly elevated in the serum and tumor tissue of most malignancies. This increase in TK1 can be detected in the very early stages of malignancy, including in pre-malignant disease with an increased risk for progression. Several studies have demonstrated that elevated TK1 is found in serum months before any clinical symptoms of malignancy. It has also been demonstrated that TK1 is elevated months before clinical recurrence of malignancy. This work first sought

APA, Harvard, Vancouver, ISO, and other styles

16

Hardie, Catriona. "Aberrant DNA methylation as a diagnostic and predictive marker of ovarian cancer." Thesis, University of Glasgow, 2007. http://theses.gla.ac.uk/1305/.

Full text

Abstract:

Aberrant methylation of CpG islands (CGIs) is associated with transcriptional silencing of key tumour suppressor genes in cancer and is a frequent epigenetic event in epithelial ovarian cancer (EOC). The methylation status of 24 CGIs in a retrospective group of 142 EOCs and 16 non-tumour adjacent tissues were analysed using methylation-specific PCR (MSP) and Combined Bisulphite Restriction Analysis (COBRA) methods. CGI methylation of at least one of these loci was a frequent event in both early (78%) and late stage (60%) disease. A group of loci were identified as being methylated in 64% of ea

APA, Harvard, Vancouver, ISO, and other styles

17

Jong, Jeroen de. "Stem cell marker OCT3/4 in biology and diagnostics of Germ cell tumors." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2007. http://hdl.handle.net/1765/10637.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Fjaertoft, Gustav. "CD64 (FcγRI) Expression on Neutrophil Granulocytes : A Diagnostic Marker of Acute Bacterial Infections". Doctoral thesis, Uppsala University, Department of Women's and Children's Health, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5974.

Full text

Abstract:

<p><b>Background. </b>Newborn infants, especially preterm infants, have an increased susceptibility to serious and overwhelming bacterial as well as fungal infections. Symptoms of septicaemia in especially the very preterm neonates are vague and unspecific. No really good biochemical parameter exists today that can confirm or exclude the existence of neonatal septicaemia. The access to such a test in neonates would be most valuable, not only to assure early institution of effective antibiotic therapy when needed, but also to avoid unnecessary use of antibiotics, thereby reducing the risk of fu

APA, Harvard, Vancouver, ISO, and other styles

19

Gallucci, Antonella <1977&gt. "Caratterizzazione clinica, eziopatogenetica e ricerca di marker diagnostici nella poliradicoloneurite acuta idiopatica del cane." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amsdottorato.unibo.it/6074/.

Full text

Abstract:

La poliradicoloneurite acuta idiopatica (ACIP) è una patologia infiammatoria che interessa le radici di più nervi spinali, descritta soprattutto nel cane, più raramente nel gatto, caratterizzata da insorgenza acuta di paresi/paralisi flaccida. L’ACIP mostra notevoli similitudini con la sindrome di Guillan-Barrè dell’uomo (GBS), in cui la patogenesi è su base autoimmunitaria ed è stata correlata con la presenza di alcuni fattori scatenanti (trigger). Lo scopo di questo lavoro è stato quello di caratterizzare l’ACIP in 26 cani, descrivendone la sintomatologia, l’evoluzione clinica, i risultati

APA, Harvard, Vancouver, ISO, and other styles

20

Dreesman, Alexandra. "Development and evaluation of new diagnostic markers of tuberculosis in children." Doctoral thesis, Universite Libre de Bruxelles, 2020. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/312223.

Full text

Abstract:

Tuberculosis in the number one infectious cause of death worldwide, but remains underappreciated as a cause of mortality in children and difficult to diagnose. Diagnostic difficulties of TB in children are a consequence of the non-specific clinical presentation, the different spectrum of disease in children and the paucibacillary nature of disease making microbiological confirmation challenging in many cases. Moreover, existing immunodiagnostic tests have important limitations, especially with regard to childhood TB: they lack sensitivity to rule out TB, and are unable to offer discrimination

APA, Harvard, Vancouver, ISO, and other styles

21

Nouzová, Eva. "Eye movements as diagnostic trait markers for adult major depressive disorder." Thesis, University of Aberdeen, 2016. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=230162.

Full text

Abstract:

Diagnosis of Major Depressive Disorder (MDD) is currently symptom-based and no externally validated tests are available for routine use to confirm clinical diagnoses. Eye movement abnormalities in schizophrenia (SCZ) and bipolar disorder (BPAD) have been consistently reported and their potential as a biological trait marker highlighted. Only a limited amount of research has been conducted in MDD. Eye movement performance of MDD patients (n = 99; F:M = 55:44; Mdn age = 48) was investigated using picture free-viewing, smooth pursuit and fixation stability tasks and recorded using a non-invasive

APA, Harvard, Vancouver, ISO, and other styles

22

Scott, Ian Stuart. "The diagnostic and therapeutic implications of cell cycle marker expression in primary intracranial neoplasms." Thesis, Queen Mary, University of London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406240.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Leo, Elisa <1981&gt. "Marker molecolari relativi all'infezione da Papillomavirus umani: significato diagnostico e prognostico in lesioni virus-correlate." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amsdottorato.unibo.it/2297/.

Full text

Abstract:

Introduzione: Il cervico-carcinoma è la seconda neoplasia maligna per incidenza e mortalità nelle donne in tutto il mondo dopo il cancro al seno. L’infezione persistente da Papillomavirus Umani (HPV) è causa necessaria dell’insorgenza del cervico-carcinoma e delle sue lesioni pre-cancerose. L’infezione da HPV si associa anche ad altri carcinomi del distretto ano-genitale (a livello anale, vulvare, vaginale e del pene) e a circa il 25% dei carcinomi squamosi dell’orofaringe. I circa 40 genotipi di HPV che infettano la mucosa genitale vengono suddivisi in alto rischio (HR-HPV) e basso rischio (

APA, Harvard, Vancouver, ISO, and other styles

24

Arko-Mensah, John. "Mycobacterial infection: Immune evasion, host susceptibility and immunological markers of diagnostic importance." Doctoral thesis, Stockholm University, Wenner-Gren Institute for Experimental Biology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-8208.

Full text

Abstract:

<p>IIn the first study, we investigated the functional implications of prolonged TLR signalling on IFN-γ mediated killing of mycobacteria by murine macrophages <i>in vitro</i>. TLR2, but not TLR4 ligation interfered with IFN-γ mediated killing of mycobacteria in macrophages. In terms of mechanisms, neither TNF nor nitric oxide (NO) production was significantly affected, and the refractoriness induced could be reversed with increasing amounts of IFN-γ In the second study, we aimed to identify immunological markers of diagnostic importance in both the respiratory tract and serum during pulmonary

APA, Harvard, Vancouver, ISO, and other styles

25

Scharf, Sonja. "Validierung des NMP22®BladderChek als Marker für das Harnblasenkarzinom an der Photodynamischen Diagnostik (PDD)." Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-92040.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Steiner, Melanie [Verfasser]. "Immunoproteasom und Proteasomaktivator 28 als Marker in der Diagnostik von Autoimmun- und Tumorerkrankungen / Melanie Steiner." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/1148425691/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Fjaertoft, Gustav. "CD64 (Fcg[gamma]RI) expression on neutrophil granulocytes a diagnostic marker of acute bacterial infections /." Uppsala : Uppsala Universitet, 2005. http://uu.diva-portal.org/smash/get/diva2:167060/FULLTEXT01.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Scharf, Sonja. "Validierung des NMP22®BladderChek als Marker für das Harnblasenkarzinom an der Photodynamischen Diagnostik (PDD)." kostenfrei, 2008. http://edoc.ub.uni-muenchen.de/9204/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Toman, Karel. "Metody stanovení nádorových markerů v krevní plazmě a jejich klinický význam při diagnostice." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2014. http://www.nusl.cz/ntk/nusl-217015.

Full text

Abstract:

The thesis discusses the methods of determination of tumor markers and their clinical importance in medical diagnostics. The theoretical part describes clinically important tumor markers and also the chemiluminescent immunoassay methods used for their determination. The practical part of the thesis describes the introduction of new chemiluminescent methods for the determination of tumor markers in routine operation, evaluates its basic analytical parameters and compares it with the existing immunoturbidimetric method. The practical part also presents results of monitoring of cancer patients wi

APA, Harvard, Vancouver, ISO, and other styles

30

Senzolo, Mara <1982&gt. "Valutazione di marker diagnostici, epidemiologia e nuove prospettive terapeutiche nell' avvelenamento da rodenticidi anticoagulanti nel cane." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6677/.

Full text

Abstract:

In Medicina Veterinaria l'avvelenamento da rodenticidi anticoagulanti è conosciuto e studiato ormai da anni, essendo una delle intossicazioni più comunemente riscontrate nelle specie non target. In letteratura si rinvengono numerose pubblicazioni ma alcuni aspetti sono rimasti ancora inesplorati.Questo studio si propone di valutare il processo infiammatorio, mediante le proteine di fase acuta (APPs), in corso di fenomeni emorragici, prendendo come modello reale un gruppo di soggetti accidentalmente avvelenati da rodenticidi anticoagulanti. I 102 soggetti avvelenati presentano un valore più e

APA, Harvard, Vancouver, ISO, and other styles

31

Scholler, Daniel [Verfasser]. "Wertigkeit des Markers S100 in der Diagnostik kindlicher Schädel-Hirn-Traumata / Daniel Scholler." Ulm : Universität Ulm. Medizinische Fakultät, 2012. http://d-nb.info/1025293916/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Ansari, Dominic O. "Raman-encoded nanoparticles for biomolecular detection and cancer diagnostics." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/26664.

Full text

Abstract:

Thesis (Ph. D.)--Biomedical Engineering, Georgia Institute of Technology, 2009.<br>Committee Chair: Nie, Shuming; Committee Member: Parkos, Charles; Committee Member: Petros, John; Committee Member: Voit, Eberhard; Committee Member: Zhu, Cheng. Part of the SMARTech Electronic Thesis and Dissertation Collection.

APA, Harvard, Vancouver, ISO, and other styles

33

Ortner, Margarete. "Morpho-functional markers in X-ray computed tomography for respiratory diseases." Paris 5, 2011. http://www.theses.fr/2011PA05S007.

Full text

Abstract:

Ce travail vise à développer un système de diagnostic assisté par ordinateur ciblant les maladies pulmonaires responsables de changements biologiques et morphologiques dans les voies respiratoires. L'intérêt clinique est la compréhension des mécanismes et relations entre la physiologie et le phénotype / génotype du patient. Ce système DAO adopte le concept "image comme marqueur" et explore les données MDCT obtenues en routine clinique. Ainsi, des approches d’investigation basées sur l'image sont abordées pour identifier les marqueurs pathologiques en jeu. L’enjeu majeur est la segmentation vol

APA, Harvard, Vancouver, ISO, and other styles

34

Honing, Jennifer. "Evaluation and implementation of DNA-based diagnostic methodology to distinguish wheat genotypes." Thesis, Link to the online version, 2007. http://hdl.handle.net/10019/638.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Abou, Farha Khalid Mohamed Mohamed. "Diagnostic and prognostic value of laminin as a biochemical and a histological marker in human bladder carcinoma." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1992. http://arno.unimaas.nl/show.cgi?fid=6506.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Rogalinski, Sebastian [Verfasser], and Holger [Akademischer Betreuer] Rambold. "Ocular-Following Response - Ein möglicher subklinischer Marker in der Diagnostik der Migräne / Sebastian Rogalinski ; Betreuer: Holger Rambold." Regensburg : Universitätsbibliothek Regensburg, 2017. http://d-nb.info/1145292089/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Carpio, Ricardo, Juan Zapata, Eberhard Spanuth, and Georg Hess. "Utility of presepsin (sCD14-ST) as a diagnostic and prognostic marker of sepsis in the emergency department." Elsevier B.V, 2015. http://hdl.handle.net/10757/576944.

Full text

Abstract:

Presepsin (PSEP) is released during infectious diseases and can be detected in the blood. PSEP has shown promising results as sepsis marker. We examined the diagnostic and prognostic validity of PSEP in patients suspicious of sepsis on admission in the emergency department (ED). Methods One hundred twenty three patients with signs of SIRS and/or sepsis and 123 healthy individuals were enrolled. PSEP was determined on admission, after 8, 24 and 72 h. Results Mean PSEP concentrations of the control group and the patient group were 130 and 1945 pg/ml. PSEP differed between SIRS, sepsis, severe se

APA, Harvard, Vancouver, ISO, and other styles

38

Sahli, David. "Early arterial disease of the lower extremities in diabetes diagnostic evaluation and risk markers /." Doctoral thesis, Umeå : Umeå university, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-26711.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Duong, Veasna. "Dengue in Cambodia : epidemiology, molecular evolution, clinical presentation, laboratory diagnostic and markers of severity." Thesis, Montpellier 2, 2011. http://www.theses.fr/2011MON20231/document.

Full text

Abstract:

La dengue, maladie transmise par des moustiques, est causée par l'un des 4 sérotypes du virus de la dengue (DENV). Le Cambodge est un pays d'hyperendémicité de la dengue où les 4 sérotypes en co-circulent. Le programme national de lutte contre la dengue a été établi en 2000 et a fourni des données nécessaires dans la compréhension du profil épidémiologique et de l'évolution du DENV. La dynamique d'évolution virale est caractérisée par des événements de disparition et d'émergence de lignées au sein de chaque sérotype en fonction du temps. La dengue se présente sous différentes formes cliniques

APA, Harvard, Vancouver, ISO, and other styles

40

Gaigneaux, Anthoula. "Determination of diagnostic and prognostic markers in varied tumoral pathologies by ATR-FTIR spectroscopy." Doctoral thesis, Universite Libre de Bruxelles, 2004. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211150.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Huggett, M. T. "The use of novel diagnostic cell cycle markers and targeted treatment of pancreaticobiliary cancers." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1433745/.

Full text

Abstract:

Adenocarcinoma of the pancreas is one of the top ten leading causes of cancer deaths. In the UK approximately 8000 people are diagnosed with the disease each year. Surgical resection is the only chance of cure and is only possible in a minority of patients. Even after resection, median survival is only 10–20 months and no more than 5–20% of resected patients survive five years. Earlier diagnostic assays and novel treatments are urgently required to improve outcomes. Chapter 1 summarises clinical aspects of pancreatic cancer and current diagnostic and prognostic tests. Chapter 2 gives an introd

APA, Harvard, Vancouver, ISO, and other styles

42

Roupaka, Sofia. "Functional genomics approach to identifying peripheral markers for sheep scrapie." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/33306.

Full text

Abstract:

Scrapie is a transmissible spongiform encephalopathy (TSE) of sheep and goats, for which there is currently no ante-mortem diagnostic test. A rapid, ante-mortem diagnostic test for scrapie would also potentially be important for other TSEs such as bovine spongiform encephalopathy (BSE) and variant Creutzfeldt Jakob's disease (vCJD). The hypothesis of this study was that there is differential gene expression in the blood and peripheral tissues of scrapie infected animals, and that a panel of differentially expressed genes could be identified and used as surrogate markers of infection. An expres

APA, Harvard, Vancouver, ISO, and other styles

43

Nagala, Sidhartha. "Correlating thyroid tumour pathology with magnetic resonance biomarkers to improve pre-operative diagnosis." Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708232.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Brennecke, Johannes. "Molecular diagnostics of the bacterial response to antibiotic therapy." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28843.

Full text

Abstract:

Bacterial bloodstream infections (BSIs) are a major healthcare problem causing high mortality and economic cost. BSIs require an immediate initiation of antibiotic therapy as any delay is associated with a mortality increase. With the emergence of antimicrobial resistance, the choice of the appropriate antibiotic becomes increasingly difficult, thus creating an urgent need for new diagnostics, ideally to be done at the point of care. The current gold standard is blood culture with subsequent susceptibility testing although several molecular methods have recently entered the market. However, in

APA, Harvard, Vancouver, ISO, and other styles

45

Hurlbeck, Cornelia [Verfasser]. "Biochemische Marker in der Diagnostik der Osteoarthritis infolge des fragmentierten Processus coronoideus medialis ulnae beim Hund / Cornelia Hurlbeck." Berlin : Freie Universität Berlin, 2011. http://d-nb.info/1026265258/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Tripská, Katarína. "miRNA jako diagnostické markery v revmatologii po terapii glukokortikoidy." Master's thesis, 2018. http://www.nusl.cz/ntk/nusl-388781.

Full text

Abstract:

Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Katarína Tripská Supervisor: prof. PharmDr. Petr Pávek, Ph.D. Title of diploma thesis: miRNAs as diagnostic markers after treatment with glucocorticoids in rheumatology MicroRNAs are important class of non-coding RNAs that play important role in modulation of expression of multiple genes at a post-transcriptional level. Their deregulation contributes to many immune disorders including rheumatoid arthritis, systemic lupus erythematosus and systemic sclerosis. This thesis represents the most

APA, Harvard, Vancouver, ISO, and other styles

47

Pospíšilová, Klára. "Využití specifických inhibitorů karbonické anhydrázy IX pro fluorescenční značení rakovinných buněk." Master's thesis, 2016. http://www.nusl.cz/ntk/nusl-348323.

Full text

Abstract:

Human carbonic anhydrases are metalloenzymes that are involved in many physiological processes in the body, but also play an important role in the pathogenesis of numerous diseases. Under regular conditions, expression of carbonic anhydrase IX (CAIX) is very limited, unlike that of other 14 human carbonic anhydrase isozymes. But in hypoxic tumors this enzyme is highly overexpressed on the cell surface. For this reason, this enzyme represents a good target for therapy and diagnosis of tumors and thus various anti-CAIX monoclonal antibodies and specific inhibitors are being developed. In this wo

APA, Harvard, Vancouver, ISO, and other styles

48

Sedláková, Zdeňka. "Zvýšení diagnostické efektivity QF-PCR pro vyšetření aneuploidií z plodové vody." Master's thesis, 2013. http://www.nusl.cz/ntk/nusl-322417.

Full text

Abstract:

Quantitative fluorescence polymerase chain reaction (QF-PCR) is a molecular genetic method based on the amplification of microsatellites (Short tandem repeats, STR) and measurement of the peak heights of amplicons in the electropherogram. Currently, the QF- PCR deemed reliable, fast, and inexpensive method that is gradually replacing conventional cytogenetic analysis of aneuploidy (examination of long-term cultures of amniotic fluid). However, in certain cases it is impossible to determine the parental origin and meiotic aneuploidy by QF-PCR. The aim of this work was to verify the new dinucleo

APA, Harvard, Vancouver, ISO, and other styles

49

Veškrňová, Veronika. "Diagnostické a prognostické markery v éře cílené léčby CRC." Doctoral thesis, 2021. http://www.nusl.cz/ntk/nusl-438791.

Full text

Abstract:

Introduction: Colorectal cancer (CRC) is the most common malignant tumor in both sexes in the Czech Republic. Prognostic factors in CRC can be classified as clinical (stage at the time of diagnosis, histological type of tumor), genetic (RAS, BRAF), immunological (Immunoscore)and biochemical (CEA, CA 19-9, miRNA). MicroRNAs (miRNAs) regulate the expression of oncogenes and tumor suppressors. The regulatory function of miRNAs is influenced by single nucleotide polymorphisms (SNPs) of target miRNA binding sites (miRSNPs). Aims: To evaluate the currently available prognostic factors for CRC patien

APA, Harvard, Vancouver, ISO, and other styles

50

Ondrušková, Nina. "Studium transferinu jako markeru dědičných poruch glykosylace." Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-296231.

Full text

Abstract:

Congenital disorders of glycosylation (CDG) represent a heterogeneous group of mul- tisystemic metabolic disorders which are caused by defects in biosynthetic pathways of glycoproteins. The screening test for N-glycosylation disorders is the analyses of sialylated isoforms of serum transferrin (Tf) by means of isoelectric focusing (IEF). Two distinct pathological IEF patterns of Tf are observed. A type I pattern is cha- racterized by a decrease of tetra- and an increase of di- and asialotransferrin, whereas a type II pattern shows in addition an increase of tri- and monosialotransferrin. The a

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!