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Journal articles on the topic 'Diagnostický marker'

Author: Grafiati

Published: 4 June 2021

Last updated: 16 February 2022

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1

Goncharov, D. B., E. V. Abbazova, V. A. Kovaleva, B. I. Maracusha, and I. V. Titova. "STRATEGY FOR THE DIAGNOSTICS OF TOXOPLASMOSIS IN DIFFERENT POPULATION GROUPS." Medical Parasitology and Parasitic Diseases, no. 1 (2021): 29–36. http://dx.doi.org/10.33092/0025-8326mp2021.1.29-36.

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The analysis of laboratory examination of the population with latent and chronic toxoplasmosis has a number of complexities. Therefore, the search for accurate biomarkers of toxoplasmosis to differentiate the stage of invasion development is very important. From the group of 559 persons, the infection of T. gondii was found in 27,9%. It is shown that a person is more often infected in childhood, teenage years and adolescence, which is marked by the presence of IgM antibodies and high levels of IgG antibodies. It was confirmed that IgA antibodies is an effective marker of reactivation of latent

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Janota, Tomáš. "Biochemical markers in the diagnosis of myocardial infarction." Cor et Vasa 56, no. 4 (2014): e304-e310. http://dx.doi.org/10.1016/j.crvasa.2014.06.007.

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Nováková, Barbora, and Radan Brůha. "Serum markers in diagnostics of steatohepatitis." Vnitřní lékařství 65, no. 9 (2019): 577–82. http://dx.doi.org/10.36290/vnl.2019.099.

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Wdowiak, M., A. Rychlik, and A. Kołodziejska-Sawerska. "Biomarkers in canine inflammatory bowel disease diagnostics." Polish Journal of Veterinary Sciences 16, no. 3 (2013): 601–10. http://dx.doi.org/10.2478/pjvs-2013-0085.

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Abstract Canine inflammatory bowel disease (IBD) is a heterogeneous group of chronic gastrointestinal disorders. The etiology, similar to human IBD, remains unknown. Canine IBD is diagnosed by exclusion, which is a long, time and money-consuming process due to the need of elimination of other diseases presenting with similar symptoms. Therefore, a search for a specific and sensitive marker is needed to overcome these difficulties. The article is divided into 3 sections presenting up-to-date information about laboratory markers, immunohistochemical markers and changes in the neurochemical codin

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Garg, Dr Ankur. "Umbilical Cord Bilirubin-an Early Diagnostic Marker of Significant Neonatal Hyperbilirubinemia." Journal of Medical Science And clinical Research 05, no. 04 (2017): 20345–49. http://dx.doi.org/10.18535/jmscr/v5i4.99.

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6

Skorodumova, L. O., A. V. Belodedova, E. I. Sharova, and B. E. Malyugin. "Search for genetic markers for precise diagnostics of keratoconus." Biomeditsinskaya Khimiya 65, no. 1 (2019): 9–20. http://dx.doi.org/10.18097/pbmc20196501009.

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Keratoconus is a chronic disorder of the cornea, characterized by its progressive thinning, stretching, and conical protrusion. Diagnostics of subclinical keratoconus, as well as its early stages (forme fruste), is a complex problem. The presence of these forms of keratoconus in a patient is one of the reasons for the development of keratectasia after laser refractive surgery. Currently, the role of genetic factors in keratoconus development has been proven. This indicates the possibility of diagnostics of subclinical and forme fruste keratoconus using genetic markers. Knowledge about the pati

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Hasić, Sabaheta, Emina Kiseljaković, Radivoj Jadrić, Jovan Radovanović, and Mira Winterhalter-Jadrić. "Cardiac troponin I: the gold standard in acute myocardial infarction diagnosis." Bosnian Journal of Basic Medical Sciences 3, no. 3 (2003): 41–44. http://dx.doi.org/10.17305/bjbms.2003.3527.

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Cardiovascular diseases are leading cause of morbidity in the world. Measurement of the level of biochemical markers in the serum is one of World Health Organisation (WHO) criteria in diagnosing acute myocardial infarction (AMI). Non-specific clinical state of patients and insufficiently sensitive electrocardiographic (ECG) diagnostics, at patient's hospital admission time, point out the importance of biochemical markers in acute myocardial infarction diagnosis. Technology development and new diagnostic methods lead to the invention of highly sensitive and specific marker as myocardialdamage e

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Neuhaus, Jochen, Thilo Schwalenberg, Lars-Christian Horn, Henry Alexander, and Jens-Uwe Stolzenburg. "New Aspects in the Differential Diagnosis and Therapy of Bladder Pain Syndrome/Interstitial Cystitis." Advances in Urology 2011 (2011): 1–9. http://dx.doi.org/10.1155/2011/639479.

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Diagnosis of bladder pain syndrome/interstitial cystitis (BPS/IC) is presently based on mainly clinical symptoms. BPS/IC can be considered as a worst-case scenario of bladder overactivity of unknown origin, including bladder pain. Usually, patients are partially or completely resistant to anticholinergic therapy, and therapeutical options are especially restricted in case of BPS/IC. Therefore, early detection of patients prone to develop BPS/IC symptoms is essential for successful therapy. We propose extended diagnostics including molecular markers. Differential diagnosis should be based on th

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Bünger, Stefanie, Ulrike Haug, Frances Maria Kelly, et al. "Toward Standardized High-Throughput Serum Diagnostics." Journal of Biomolecular Screening 16, no. 9 (2011): 1018–26. http://dx.doi.org/10.1177/1087057111414894.

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Development and progression of colon cancer may be related to cytokines. Cytokines with diagnostic value have been identified individually but have not been implemented into clinical praxis. Using a multiplex protein array, the authors explore a panel of cytokines simultaneously and compared its performance to carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9). Serum concentrations of 12 cytokines were simultaneously determined by multiplex biochip technology in 50 colon cancer patients and 50 healthy controls. Serum levels of interleukin-8 (IL-8) and CEA were significantly

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Han, Henry, and Ying Liu. "Transcriptome marker diagnostics using big data." IET Systems Biology 10, no. 1 (2016): 41–48. http://dx.doi.org/10.1049/iet-syb.2015.0026.

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Jensen, Niels Einar, та Kim Knudsen. "Interquarter comparison of markers of subclinical mastitis: somatic cell count, electrical conductivity, N-acetyl-β-glucosaminidase and antitrypsin". Journal of Dairy Research 58, № 4 (1991): 389–99. http://dx.doi.org/10.1017/s002202990002999x.

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SummaryWe have evaluated the usefulness in mastitis diagnostics of new diagnostic measures using the continuous nature of the variation in quarter milk samples of four inflammatory markers: somatic cell count, N-acetyl-β-glucosaminidase (EC 3.2.1.30), electrical conductivity and antitrypsin. A two-way analysis of variance was performed for each of the inflammatory markers on results from 273 cows sampled six times at 14 d intervals. Adjustment for the individual cow's mean removed approximately half the total variation for all four markers, indicating that comparisons in marker levels between

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Rud, Yu P. "THE RAPID DIAGNOSTICS OF SEX OF SALMONIDS USING DNA-MARKERS." Biotechnologia acta 7, no. 6 (2014): 17–22. http://dx.doi.org/10.15407/biotech7.06.017.

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13

Gregáňová, Ž., J. Kraic, and Z. Gálová. "Diagnostic of Wheat Leaf Rust Resistance Genes by DNA Markers and their Application in MAS – Short Communication." Czech Journal of Genetics and Plant Breeding 39, No. 4 (2011): 127–29. http://dx.doi.org/10.17221/3730-cjgpb.

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Leaf rust caused by Puccinia triticina belongs to the most important wheat diseases in Europe, including Slovakia. Winter wheat varieties registered in Slovakia have been tested with already developed STS (Lr9, Lr24), SCAR (Lr35) and SSR (Lr13) markers which are linked to the mentioned leaf rust resistance genes. Each of the four DNA markers linked to the individual resistance gene can be detected safely, easily and relatively fast by using the PCR reaction. This is very important for marker assisted selection (MAS) for the incorporation of the Lr9, Lr24 a Lr35 genes into chosen wheat genotype

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Shrivastava, Rajesh Kumar, Mukesh Meena, Meena Varma, Rajesh Kumar Jha Rajesh Kumar Jha, Susmit Kosta, and Ravindra Kumar. "Is TSH Alone Can be A Treated as Diagnostic Marker for Thyroid Disorders." Indian Journal of Applied Research 3, no. 11 (2011): 361–63. http://dx.doi.org/10.15373/2249555x/nov2013/112.

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15

Bacanakgil, Besim Haluk, Işık Kaban, Mushviga Hasanova, and Mustafa Deveci. "Preoperative diagnostic value of hematologic inflammatory markers in ovarian torsion." New Indian Journal of OBGYN 6, no. 1 (2019): 11–14. http://dx.doi.org/10.21276/obgyn.2019.6.1.3.

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Globa, A. G., V. S. Demidova, O. N. Dikova, V. A. Vishnevskiy, and A. I. Shchegolyev. "The study of RNA markers in blood of patients with malignant tumors of gastrointestinal tract." Biomeditsinskaya Khimiya 56, no. 4 (2010): 510–16. http://dx.doi.org/10.18097/pbmc20105604510.

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In order to develop a diagnostic panel, mRNA levels of tumor marker genes have been evaluated in capillary blood of patients with various malignant tumors of the gastrointestinal tract (GIT) by means of the method of reverse transcription combined with real-time PCR with detection of reaction products using TaqMan probes. Use of small volumes of capillary blood did not decrease sensitivity of this method. RNA expression of telomerase (mhTERT), alpha-fetoprotein (mAFP), carcinoembryonic antigen (mCEA) and cytokeratin-20 (mCK-20) was higher in most patients with tumors. Blood of donors or non-on

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Brana, Irene, Christophe Massard, Richard D. Baird, et al. "Basket of baskets (BoB): A modular, open label, phase II, multicenter study to evaluate targeted agents in molecularly selected populations with advanced solid tumors." Journal of Clinical Oncology 37, no. 15_suppl (2019): TPS3151. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.tps3151.

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TPS3151 Background: Basket trials with targeted agents can show high response rates for tumors with specific molecular profiles, granting extension of the label of some drugs. In other cases, study results were disappointing, likely due to the rarity of molecular alterations, limits in trial design and the difficulties in applying molecular tumor profiling in the clinical setting. Methods: Basket of Baskets (BoB), NCT03767075, aims to bridge the gap between Academic Genomics and clinical applications (ready-to market multi-marker Companion Diagnostics) by providing a sustainable and adaptable

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Zajkowska, Monika, Maciej Szmitkowski, Sławomir Ławicki, and Emilia Lubowicka. "VEGF family factors and their receptors in the diagnostics of breast cancer." Diagnostyka Laboratoryjna 54, no. 2 (2019): 105–12. http://dx.doi.org/10.5604/01.3001.0013.7695.

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Breast cancer since many years is the most widespread cancer in women and one of the most common causes of their death related to malignancies. Currently in breast cancer diagnosis, the most popular screening test is mammography. However, this is not a sufficiently sensitive method, therefore, other diagnostic tests are performed to detect new cancer markers. In the case of breast cancer, the currently accepted marker is CA 15-3. However, it does not show sufficiently high diagnostic sensitivity, does not accelerate the diagnostic process, which simultaneously contributes to the delayed diagno

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19

Schatz, Peer. "The Growing Molecular Diagnostics Market." BioProcessing Journal 6, no. 3 (2007): 56–57. http://dx.doi.org/10.12665/j63.schatz.

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Philippidis, Alex. "Companion Diagnostics Market Grows Rapidly." Clinical OMICs 3, no. 6 (2016): 23. http://dx.doi.org/10.1089/clinomi.03.06.09.

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21

Sahl, Jason W., Carolyn R. Morris, Jennifer Emberger, et al. "Defining the Phylogenomics of Shigella Species: a Pathway to Diagnostics." Journal of Clinical Microbiology 53, no. 3 (2015): 951–60. http://dx.doi.org/10.1128/jcm.03527-14.

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Shigellae cause significant diarrheal disease and mortality in humans, as there are approximately 163 million episodes of shigellosis and 1.1 million deaths annually. While significant strides have been made in the understanding of the pathogenesis, few studies on the genomic content of theShigellaspecies have been completed. The goal of this study was to characterize the genomic diversity ofShigellaspecies through sequencing of 55 isolates representing members of each of the fourShigellaspecies:S. flexneri,S. sonnei,S. boydii, andS. dysenteriae. Phylogeny inferred from 336 availableShigellaan

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22

Mazur, O. H., O. S. Yablon, and O. S. Rubina. "Alpha-fetoprotein as a biochemical diagnostic and prognostic marker for prolonged jaundice in newborns." Ukrainian Biochemical Journal 91, no. 5 (2019): 63–69. http://dx.doi.org/10.15407/ubj91.05.063.

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23

Hanke, Merle, Ingo Kausch, Gerlinde Dahmen, Dieter Jocham, and Jens M. Warnecke. "Detailed Technical Analysis of Urine RNA-Based Tumor Diagnostics Reveals ETS2/Urokinase Plasminogen Activator to Be a Novel Marker for Bladder Cancer." Clinical Chemistry 53, no. 12 (2007): 2070–77. http://dx.doi.org/10.1373/clinchem.2007.091363.

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Abstract Background: The noninvasive detection of RNA tumor markers in body fluids represents an attractive diagnostic option, but diagnostic performance of tissue-derived markers is often poorer when measured in body fluids rather than in tumors. We aimed to develop a procedure for measurement of tumor RNA in urine that would minimize donor-dependent influences on the results. Methods: RNA isolated from urinary cell pellet, cell-depleted fraction, and whole urine was quantified by reverse transcription quantitative–PCR. The donor-dependent influence of urine background on individual steps of

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Kretschmer-Kazemi Far, Rosel, Kirsten Frank, and Georg Sczakiel. "Sampling, Logistics, and Analytics of Urine for RT-qPCR-based Diagnostics." Cancers 13, no. 17 (2021): 4381. http://dx.doi.org/10.3390/cancers13174381.

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Body fluids in the context of cancer diagnosis are the primary source of liquid biopsy, i.e., biomarker detection that includes blood and serum, urine, and saliva. RNA represents a particular class of biomarkers because it is thought to monitor the current status of gene expression in humans, in organs, and if present, also in tumors. In case of bladder cancer, we developed a scheme that describes, in detail, all steps from the collection of urine samples from patients, stabilization of samples, their transportation, storage, and marker analysis by qPCR-based technology. We find that urine sam

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Singh J, Ashwin, M. Jayasabarinathan, and Sheela Grace Jeevamani. "IDENTIFICATION OF MICRONUCLEUS IN BUCCAL MUCOSA OF TYPE -2 DIABETIC PATIENTS: AN EARLY DIAGNOSTIC MARKER." International Journal of Anatomy and Research 4, no. 2 (2016): 2412–15. http://dx.doi.org/10.16965/ijar.2016.219.

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Afsar, Nabila, Idrees Akhtar Afroze, Shahmeen Humaira, and Zakia Abid. "IUse of Mean platelet Volume as an initial diagnostic marker in evaluation of dengue fever." Annals of Pathology and Laboratory Medicine 4, no. 3 (2017): A310—A313. http://dx.doi.org/10.21276/apalm.1411.

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Gaddikeri, Kavitha, and Deepak D. Bhorgonde. "Estimation of Serum Lipid Profile Patterns As A Diagnostic Marker In Oral Cancer and Precancer." Asian Pacific Journal of Health Sciences 3, Supplimentary 2016 (2016): 59–62. http://dx.doi.org/10.21276/apjhs.2016.3.4s.8.

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28

Vogel, J. M., A. Rafalski, M. Morgante, et al. "The Application of Genetic Diagnostics to Plant Genome Analysis and Plant Breeding." HortScience 30, no. 4 (1995): 749A—749. http://dx.doi.org/10.21273/hortsci.30.4.749a.

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DNA-based diagnostics are now well-established as a means to assay diversity at the locus, chromosome, and whole-genome levels. As technology has advanced, DNA sequence-based assays have become easier to use, more efficient at screening for nucleotide sequence-based polymorphisms, and available to a wider cross-section of the research community. A review of the use of molecular markers in several different areas of genetics and plant breeding will be presented, as well as a discussion about their advantages and limitations. Recent advances in several areas of technology development and laborat

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Conley, Barbara A., and Sheila E. Taube. "Prognostic and Predictive Markers in Cancer." Disease Markers 20, no. 2 (2004): 35–43. http://dx.doi.org/10.1155/2004/202031.

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The elucidation of the human genome and advances in knowledge about molecular abnormalities, signaling pathways, influence of the local tissue milieu and the relevance of genetic polymorphisms offer hope of designing more effective, individualized cancer treatment plans. Although the scientific and medical literature is replete with reports of putative prognostic or predictive markers for cancer, few new diagnostics have been incorporated into routine clinical practice. Criteria are needed to a) identify markers that have the promise to be clinically useful; b) assess the best methodology for

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Pytlak, Beata, Monika Prochorec-Sobieszek, and Anna Szumera-Ciećkiewicz. "SOX10 as an immunohistochemical marker in cancer diagnostics." Nowotwory. Journal of Oncology 69, no. 2 (2019): 58–64. http://dx.doi.org/10.5603/njo.2019.0011.

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Liehr, Thomas, Elisabeth Ewers, Nadezda Kosyakova, et al. "Handling small supernumerary marker chromosomes in prenatal diagnostics." Expert Review of Molecular Diagnostics 9, no. 4 (2009): 317–24. http://dx.doi.org/10.1586/erm.09.17.

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RAI, ALEX J., and DANIEL W. CHAN. "Cancer Proteomics: Serum Diagnostics for Tumor Marker Discovery." Annals of the New York Academy of Sciences 1022, no. 1 (2004): 286–94. http://dx.doi.org/10.1196/annals.1318.044.

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Kato, Meredith A., and Thomas J. Fahey. "Molecular Markers in Thyroid Cancer Diagnostics." Surgical Clinics of North America 89, no. 5 (2009): 1139–55. http://dx.doi.org/10.1016/j.suc.2009.06.012.

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Ostashko, M. P., and T. I. Nasonova. "MARKERS OF NEUROVISULATION IN MIGRAINE DIAGNOSTICS." PRECARPATHIAN BULLETIN OF THE SHEVCHENKO SCIENTIFIC SOCIETY Pulse, no. 5(57) (April 24, 2019): 108–13. http://dx.doi.org/10.21802/2304-7437-2019-5(57)-108-113.

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In clinical medicine, the diagnosis of migraine is based on anamnesis and symptoms, and instrumental diagnostic methods are considered non-informative. Numerous studies of the brain, during headaches and between them, have made a significant contribution to understanding the pathophysiology of migraines. Structural and functional changes in the migraine brain are revealed by advanced magnetic resonance imaging techniques, and attempts to detect the visualization markers of this disease progressively increase. This overview article aims to summarize the results of recent studies that reflect ac

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Ostashko, M. P., and T. I. Nasonova. "MARKERS OF NEUROVISULATION IN MIGRAINE DIAGNOSTICS." PRECARPATHIAN BULLETIN OF THE SHEVCHENKO SCIENTIFIC SOCIETY Pulse, no. 5(57) (April 24, 2019): 108–13. http://dx.doi.org/10.21802/10.21802/2304-7437-2019-5(57)-108-113.

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In clinical medicine, the diagnosis of migraine is based on anamnesis and symptoms, and instrumental diagnostic methods are considered non-informative. Numerous studies of the brain, during headaches and between them, have made a significant contribution to understanding the pathophysiology of migraines. Structural and functional changes in the migraine brain are revealed by advanced magnetic resonance imaging techniques, and attempts to detect the visualization markers of this disease progressively increase. This overview article aims to summarize the results of recent studies that reflect ac

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Kondratova, V. N., M. V. Lomaya, A. V. Ignatova, et al. "EPSTEIN-BARR VIRUS AND NASOPHARYNGEAL CARCINOMA: VIRAL MARKERS FOR DIAGNOSTICS AND ASSESSMENT OF CLINICAL STATUS OF PATIENTS." Problems of Virology, Russian journal 63, no. 2 (2018): 77–84. http://dx.doi.org/10.18821/0507-4088-2018-63-2-77-84.

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The etiological role of the Epstein-Barr virus (EBV) in the development of an undifferentiated histological variant of nasopharyngeal carcinoma (uNPC) found for the first time in regions with a high incidence of this pathology, the Southern provinces of China and the countries of Southeast Asia, and later in the rest of the world, has served as a basis for the widespread use of EBV serological markers for the diagnosis of this form of tumor. In recent years, the use of a test based on the quantitative determination of the EBV DNA concentration in the blood plasma of uNPC patients for early det

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Fazeli, Bahare, Daniela Ligi, Shayan Keramat, Rosanna Maniscalco, Hiva Sharebiani, and Ferdinando Mannello. "Recent Updates and Advances in Winiwarter-Buerger Disease (Thromboangiitis Obliterans): Biomolecular Mechanisms, Diagnostics and Clinical Consequences." Diagnostics 11, no. 10 (2021): 1736. http://dx.doi.org/10.3390/diagnostics11101736.

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Thromboangiitis obliterans (TAO) or Buerger’s disease is a segmental inflammatory, thrombotic occlusive peripheral vascular disease with unknown aetiology that usually involves the medium and small-sized vessels of young male smokers. Due to its unknown aetiology and similarities with atherosclerosis and vasculitis, TAO diagnosis is still challenging. We aimed to review the status of biomolecular and laboratory para-clinical markers in TAO compared to atherosclerosis and vasculitis. We reported that, although some biomarkers might be common in TAO, atherosclerosis, and vasculitis, each disease

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Nikiforova, Marina N., and Ronald L. Hamilton. "Molecular Diagnostics of Gliomas." Archives of Pathology & Laboratory Medicine 135, no. 5 (2011): 558–68. http://dx.doi.org/10.5858/2010-0649-rair.1.

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Abstract Context.—Gliomas are the most common primary brain tumors of adults and include a variety of histologic types and morphologies. Histologic evaluation remains the gold standard for glioma diagnosis; however, diagnostic difficulty may arise from tumor heterogeneity, overlapping morphologic features, and tumor sampling. Recently, our knowledge about the genetics of these tumors has expanded, and new molecular markers have been developed. Some of these markers have shown diagnostic value, whereas others are useful prognosticators for patient survival and therapeutic response. Objective.—T

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BHAT, Zahoor Ahmad, Wasakha Singh DHILLON, Rizwan RASHID, Javid Ahmad BHAT, Waseem Ali DAR, and Mohammad Yousf GANAIE. "The role of Molecular Markers in Improvement of Fruit Crops." Notulae Scientia Biologicae 2, no. 2 (2010): 22–30. http://dx.doi.org/10.15835/nsb224222.

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Markers have been used over the years for the classification of plants. Markers are any trait of an organism that can be identified with confidence and relative easy, and can be followed in a mapping population on another hand markers be defined as heritable entities associated with the economically important trait under the control of polygenes. Morphological markers can be detected with naked eye (naked eye polymorphism) or as difference in physical or chemical properties of the macromolecules. In other words, there are two types of genetic markers viz. morphological markers or naked eye pol

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Soukup, Viktor, Marta Kalousová, Otakar Capoun, et al. "Panel of Urinary Diagnostic Markers for Non-Invasive Detection of Primary and Recurrent Urothelial Urinary Bladder Carcinoma." Urologia Internationalis 95, no. 1 (2015): 56–64. http://dx.doi.org/10.1159/000368166.

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Objectives: To determine the combination of urinary protein markers for noninvasive detection of primary and recurrent urothelial bladder carcinomas. Methods: Urinary concentrations of 27 biomarkers (NSE, ATT, AFABP, Resistin, Midkine, Clusterin, Uromodulin, ZAG2, HSP27, HSP 60, NCAM1/CD56, Angiogenin, Calreticulin, Chromogranin A, CEACAM1, CXCL1, IL13Ra2, Progranulin, VEGFA, CarbAnhydIX, Annexin-V, TIM4, Galectin1, Cystatin B, Synuclein G, ApoA1 and ApoA2) were assessed by enzyme-linked immunosorbent assay or by electrochemiluminiscence immunoassay. Results: During the primary diagnostics, a

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Coelho Adati, Marisa, Álvaro da Silva Ribeiro, Danielle Copello Vigo, et al. "Monitoramento pós-mercado dos testes rápidos para COVID-19: enfrentamento da pandemia." Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia 9, no. 3 (2021): 92–101. http://dx.doi.org/10.22239/2317-269x.01781.

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Introdução: Em dezembro de 2019, foi descoberto na cidade de Wuhan, China, um primeiro grupo de pacientes com sintomas de uma pneumonia atípica. Em 7 de janeiro de 2020, o seu agente etiológico foi identificado: tratava-se de um novo betacoronavírus, geneticamente similar ao SARS-CoV-1, constituído defita simples de RNA, vírus envelopado de 50-200 nm de diâmetro designado como SARS-CoV-2, e a doença foi denominada COVID-19. Em 30 de janeiro, a Organização Mundial da Saúde declarou Emergência de Saúde Pública de Importância Internacional em razão da disseminação desse novo vírus. Os testes para

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Markovich, A. A., N. V. Lyubimova, E. I. Kovalenko, et al. "Importance of biochemical markers in routine oncological practice (according to materials of clinical recommendations)." Medical alphabet, no. 8 (June 16, 2020): 19–24. http://dx.doi.org/10.33667/2078-5631-2020-8-19-24.

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Background. The diagnostics of neuroendocrine tumors (NET) is complex due to many factors such as the heterogeneity of the tumors themselves, different localization of the tumor process, and the presence of severe hormonal syndromes. A special place in the diagnostic search is given to the study of biochemical markers which are conditionally divided into universal and specific ones.Materials and methods. Chromogranin A (CGA) is a universal marker that in most cases identifies tumors of a neuroendocrine nature and is characterized by the best combination of diagnostic sensitivity and specificit

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Holland, Robert L. "What makes a good biomarker?" Advances in Precision Medicine 1, no. 1 (2016): 66. http://dx.doi.org/10.18063/apm.2016.01.007.

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The last decade has seen an extraordinary amount of effort devoted in biomedical research to the field of biomarkers. There have been some notable successes with novel markers being adopted into clinical practice bringing clear clinical benefit to some patients — particularly with the increasing numbers of medicines being approved with companion diagnostics. However, it is fair to say that there has not yet been the numbers of clinically valuable biomarkers brought to medical practice that the research effort would seem to warrant. This paper evaluates examples of successful biomarkers, marker

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Markou, Athina, Marifili Lazaridou, Panagiotis Paraskevopoulos, et al. "Multiplex Gene Expression Profiling of In Vivo Isolated Circulating Tumor Cells in High-Risk Prostate Cancer Patients." Clinical Chemistry 64, no. 2 (2018): 297–306. http://dx.doi.org/10.1373/clinchem.2017.275503.

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Abstract BACKGROUND Molecular characterization of circulating tumor cells (CTCs) is important for selecting patients for targeted treatments. We present, for the first time, results on gene expression profiling of CTCs isolated in vivo from high-risk prostate cancer (PCa) patients compared with CTC detected by 3 protein-based assays—CellSearch®, PSA-EPISPOT, and immunofluorescence of CellCollector® in vivo-captured CTCs—using the same blood draw. METHODS EpCAM-positive CTCs were isolated in vivo using the CellCollector from 108 high-risk PCa patients and 36 healthy volunteers. For 27 patients,

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Caramalho, Rita, Lisa Madl, Katharina Rosam, et al. "Evaluation of a Novel Mitochondrial Pan-Mucorales Marker for the Detection, Identification, Quantification, and Growth Stage Determination of Mucormycetes." Journal of Fungi 5, no. 4 (2019): 98. http://dx.doi.org/10.3390/jof5040098.

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Mucormycosis infections are infrequent yet aggressive and serious fungal infections. Early diagnosis of mucormycosis and its discrimination from other fungal infections is required for targeted treatment and more favorable patient outcomes. The majority of the molecular assays use 18 S rDNA. In the current study, we aimed to explore the potential of the mitochondrial rnl (encoding for large-subunit-ribosomal-RNA) gene as a novel molecular marker suitable for research and diagnostics. Rnl was evaluated as a marker for: (1) the Mucorales family, (2) species identification (Rhizopus arrhizus, R.

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Weller, Michael, and Roger Stupp. "Prime time for molecular marker diagnostics in neuro-oncology." Current Opinion in Neurology 25, no. 6 (2012): 743–44. http://dx.doi.org/10.1097/wco.0b013e32835a0247.

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Mikheeva, O. O., S. P. Domogatsky, E. E. Efremov, and R. S. Esipov. "Molecular markers for diagnostics of cardiac failure." Kardiologicheskii vestnik 13, no. 4 (2018): 62. http://dx.doi.org/10.17116/cardiobulletin20181304162.

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Lehrman, Sally. "‘Slick’ new company eyes medical diagnostics market." Nature 389, no. 6647 (1997): 107. http://dx.doi.org/10.1038/38067.

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Gauvin, Jeanot, Dmitry Zubakov, Joke van Rhee-Binkhorst, Ate Kloosterman, Eric Steegers, and Manfred Kayser. "Forensic pregnancy diagnostics with placental mRNA markers." International Journal of Legal Medicine 124, no. 1 (2009): 13–17. http://dx.doi.org/10.1007/s00414-008-0315-6.

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Zinsly Sampaio Camargo, Thiago, Alexandre R. Marra, Nydia Strachman Bacal, et al. "Evaluation of Two Methods for Determination of CD64 as a Diagnostic Marker of Infection in Critically Ill Adults." BioMed Research International 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/6593232.

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Objectives. Diagnostic markers of infection have had little innovation over the last few decades. CD64, a marker expressed on the surface of neutrophils, may have utility for this purpose. Methods. This study was conducted in an adult intensive care unit (ICU) in São Paulo, Brazil, with 89 patients. We evaluated CD64 in patients with documented or clinically diagnosed infection (infection group) and controls (patients without any evidence of infection) by two different methodologies: method #1, an in house assay, and method #2, the commercial kit Leuko64 (Trillium Diagnostics). Results. CD64 d

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