Academic literature on the topic 'Dihydroquinoline'

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Journal articles on the topic "Dihydroquinoline"

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Forrest, T. P., G. A. Dauphinee, and S. A. Deraniyagala. "On the mechanism of disproportionation reactions of 1,2-dihydroquinolines." Canadian Journal of Chemistry 63, no. 2 (1985): 412–17. http://dx.doi.org/10.1139/v85-068.

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The commonly accepted mechanism for the acid-catalyzed disproportionation of 1,2-dihydroquinolines involves a hydride transfer from C-2 of one dihydroquinoline molecule to C-4 of another molecule which has already been protonated at C-3. This mechanism is shown to be incorrect. The proposed intermediate is shown to react by solvent addition and not by reduction under the conditions of the reaction. Evidence has been obtained which shows that the reaction proceeds by way of a 3,4-dihydroquinoline intermediate. A possible mechanism for the formation of the intermediate is discussed.
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VOSTRIKOVA, Tatiana V., Vladislav N. KALAEV, Svetlana M. MEDVEDEVA, Nadezhda P. NOVICHIKHINA, and Khidmet S. SHIKHALIEV. "SYNTHESIZED ORGANIC COMPOUNDS AS GROWTH STIMULATORS FOR WOODY PLANTS." Periódico Tchê Química 17, no. 35 (2020): 327–37. http://dx.doi.org/10.52571/ptq.v17.n35.2020.29_vostrikova_pgs_327_337.pdf.

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The effect of synthesized organic compounds of 6-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline, its derivatives, and hydrogenated analogs on the height of seedlings of ornamental woody plants was studied. The height of seedlings as a morphometric parameter was measured 7 months after the start of the experiment. The pre-sowing seed treatment of Rhododendron ledebourii and Rhododendron smirnowii, with the studied compounds, demonstrated that dihydro- and tetrahydroquinoline with the concentration of 0.1% proved to be the most efficient. Dihydroquinolines at concentrations of 0.05 and 0.1% proved
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Marchand, Guillaume, Nathalie Wambang, Sylvain Pellegrini, et al. "Effects of Ferrocenyl 4-(Imino)-1,4-Dihydro-quinolines on Xenopus laevis Prophase I - Arrested Oocytes: Survival and Hormonal-Induced M-Phase Entry." International Journal of Molecular Sciences 21, no. 9 (2020): 3049. http://dx.doi.org/10.3390/ijms21093049.

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Xenopus oocytes were used as cellular and molecular sentinels to assess the effects of a new class of organometallic compounds called ferrocenyl dihydroquinolines that have been developed as potential anti-cancer agents. One ferrocenyl dihydroquinoline compound exerted deleterious effects on oocyte survival after 48 h of incubation at 100 μM. Two ferrocenyl dihydroquinoline compounds had an inhibitory effect on the resumption of progesterone induced oocyte meiosis, compared to controls without ferrocenyl groups. In these inhibited oocytes, no MPF (Cdk1/cyclin B) activity was detected by wester
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VOSTRIKOVA, Tatiana V., Vladislav N. KALAEV, Andrey Yu POTAPOV, MICHAIL A. POTAPOV, and Khidmet S. SHIKHALIEV. "USE OF NEW COMPOUNDS OF THE QUINOLINE SERIES AS EFFECTIVE STIMULANTS OF GROWTH PROCESSES." Periódico Tchê Química 17, no. 35 (2020): 781–90. http://dx.doi.org/10.52571/ptq.v17.n35.2020.66_vostrikova_pgs_781_790.pdf.

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The results of a study of the action of compounds of the general formula: 1-alkyl-2,2,4-trimethyl-6-aminocarbothioyl-1,2-dihydroquinoline and 1-alkyl-2,2,4-trimethyl-6-aminocarbothioyl-1,2,3,4-tetrahydroquinoline are presented. The most effective growth stimulants from compounds of the series 1-alkyl-2,2,4-trimethyl-6-aminocarbothioyl-1,2-dihydroquinoline and 1-alkyl-2,2,4-trimethyl-6-aminocarbothioyl-1,2,3,4-tetrahydroquinoline for yellow rhododendron (Rhododendron luteum) and Ledebur rhododendron (Rhododendron ledebourii) were revealed. Rhododendron seedlings were counted to study laboratory
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Vostrikova, Tatiana, Vladislav Kalaev, Svetlana Medvedeva, Irina Ledeneva, and Khidmet Shikhaliev. "Quinoline Derivatives as Growth Regulators for Ornamental Plants." Southern Brazilian Journal of Chemistry 28, no. 28 (2020): 10–16. http://dx.doi.org/10.37633/sbjc.28(28)2020.10-16.

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It is investigated the effect of synthesized organic compounds of 6-hydroxy-2,2,4-trimethyl-1,2- dihydroquinoline, its derivatives, and hydrogenated analogs. These compounds affected the height of seedlings when they were used for pre-sowing seed treatment of the following ornamental plants: annual ornamental grass – scarlet sage (Salvia splendens) and woody plant – yellow rhododendron (Rhododendron luteum). Prior to the sprouting process, the seeds of Rh. luteum and S. splendens were soaked in water solutions of compounds with concentrations of 0.01%, 0.05%, and 0.1% for 18 hours. Dihydro- an
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V. VOSTRIKOVA, Tatiana, Vladislav N. KALAEV, Svetlana M. MEDVEDEVA, Irina V. LEDENEVA, and Khidmet S. SHIKHALIEV. "QUINOLINE DERIVATIVES AS GROWTH REGULATORS FOR ORNAMENTAL PLANTS." SOUTHERN BRAZILIAN JOURNAL OF CHEMISTRY 28, no. 28 (2020): 10–16. http://dx.doi.org/10.48141/sbjchem.v28.n28.2020.02_vostrikova_pgs_10_16.pdf.

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It is investigated the effect of synthesized organic compounds of 6-hydroxy-2,2,4-trimethyl-1,2- dihydroquinoline, its derivatives, and hydrogenated analogs. These compounds affected the height of seedlings when they were used for pre-sowing seed treatment of the following ornamental plants: annual ornamental grass – scarlet sage (Salvia splendens) and woody plant – yellow rhododendron (Rhododendron luteum). Prior to the sprouting process, the seeds of Rh. luteum and S. splendens were soaked in water solutions of compounds with concentrations of 0.01%, 0.05%, and 0.1% for 18 hours. Dihydro- an
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Chinh, Pham The, Pham Thi Tham, Duong Huong Quynh, et al. "Synthesis and Cytotoxic Activity of Several Novel N-Alkyl-Plinabulin Derivatives With Aryl Group Moieties." Natural Product Communications 16, no. 4 (2021): 1934578X2110100. http://dx.doi.org/10.1177/1934578x211010040.

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Seven novel N-alkyl-plinabulin derivatives with aryl groups moieties (nitroquinoline, 1,4-dihydroquinoline, 4-methoxybenzene, and 4-chlorobenzene) have been synthesized via aldol condensation and alkylation in one-pot, and tested for their cytotoxicity against 4 cancer cell lines (KB, HepG2, Lu, and MCF7). Compounds ( Z)−3-((6,8-dimethyl-4-oxo-1,4-dihydroquinolin-2-yl)methylene)−6-(( Z)−4-methoxybenzylidene)−1-(prop-2-yn-1-yl)piperazine-2,5-dione (5a), ( Z)−6-(( Z)−4-methoxybenzylidene)−1-(prop-2-yn-1-yl)−3-((1,6,8-trimethyl-4-oxo-1,4-dihydroquinolin-2-yl)methylene)piperazine-2,5-dione (5b), a
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Hradil, Pavel, Lubomír Kvapil, Jan Hlaváč, Karel Lemr, and Juraj Ševčík. "Cyclization of Phenacyl 2-{[2,2-Di(ethoxycarbonyl)vinyl]amino}benzoate." Collection of Czechoslovak Chemical Communications 63, no. 4 (1998): 520–24. http://dx.doi.org/10.1135/cccc19980520.

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Reaction of phenacyl anthranilate (1) with diethyl (ethoxymethylidene)malonate afforded phenacyl 2-{[2,2-di(ethoxycarbonyl)vinyl]amino}benzoate (2) which on heating in polyphosphoric acid underwent degradation. Thermal cyclization of 2 in diphenyl ether gave phenacyl 3-(ethoxycarbonyl)-4-oxo-1,4-dihydroquinoline-8-carboxylate (4). The phenacyl group did not cyclize even on prolonged heating at 250 °C. Heating in sulfuric acid resulted in hydrolysis of the ethyl ester under formation of 4-oxo-8-[(phenacyloxy)carbonyl]-1,4-dihydroquinoline-3-carboxylic acid (6). The structure of 4 was confirmed
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Gaber, Ahmed, Walaa F. Alsanie, Majid Alhomrani, Abdulhakeem S. Alamri, Ibrahim M. El-Deen, and Moamen S. Refat. "Synthesis of 1-[(Aryl)(3-amino-5-oxopyrazolidin-4-ylidene) methyl]-2-oxo-1,2-dihydroquinoline-3-carboxylic Acid Derivatives and Their Breast Anticancer Activity." Crystals 11, no. 5 (2021): 571. http://dx.doi.org/10.3390/cryst11050571.

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This research aimed to produce new 1-[(aryl)(3-amino-5-oxopyrazolidin-4-ylidene) methyl]-2-oxo-1,2-dihydroquinoline-3-carboxylic acid derivatives and check their anticancer effect against the breast cancer MCF-7 cell line. The 2-oxo-1,2-dihydroquinoline-3-carboxylic acid (4) compound was obtained by hydrolyzing ethyl 2-oxo-1,2-dihydroquinoline-3-carboxylate (2) with thiourea and anhydrous potassium carbonate ethanol, which was then treated with ethyl 3-substituted 2-cyanoacrylates (6) in the presence of triethylamine in diethyl formamide to give 1-[2-(ethoxy)carbonyl-2-cyano-1-arylvinyl]-2-oxo
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Menichetti, Andrea, Francesco Berti, Lorenzo Guazzelli, et al. "Organocatalytic alkylation of carbohydrate-containing aldehydes with dihydroquinoline N,O-acetals: Absolute configuration of 1,2-dihydroquinolines." Chirality 31, no. 2 (2018): 127–37. http://dx.doi.org/10.1002/chir.23036.

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Dissertations / Theses on the topic "Dihydroquinoline"

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Henry, Axelle. "Vectorisation cérébrale de deux radiotraceurs d’intérêts pour l’imagerie, la m-iodobenzylguanidine (MIBG) et la 3’-désoxy-3’- fluoro-L-thymidine (FLT)." Thesis, Rouen, INSA, 2016. http://www.theses.fr/2016ISAM0019.

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Ce travail de recherche s'intéresse à la vectorisation au système nerveux central de la MIBG d'une part et de la FLT d'autre part. Pour cela, nous utiliserons des systèmes disposant d'une structure 1,4- dihydoquinoléine comme vecteurs. La synthèse des systèmes de vectorisation a tout d'abord été réalisée en chimie non radioactive. Concernant la MIBG, les résultats obtenus lors de précédents travaux nous ont conduit à envisager l'élaboration d'un système de vectorisation comportant un groupement espaceur entre le vecteur et la MIBG. Dans le cas de la FLT, nous nous sommes consacrés au développe
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Ismaïli, Lhassane. "Synthèse et approche immunopharmacologique de dérivés de la 1,2-dihydroquinoléine-2-one." Université de Franche-Comté. Faculté de médecine et de pharmacie, 1996. http://www.theses.fr/1996BESA3003.

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Dans une première partie, nous avons synthétisé plusieurs séries de molécules en faisant appel à des réactions d'acylation, de transpositions de Fries, d'arnidification et d'hétérocyclisation au dépa1t du quinoléine-2,4-diol ou du 1,2-dihvdroquinoleine-3-carboxylate d'éthyle. Nous avons ainsi préparé une soixantaine de composés dont certains comportent une structure tricyclique. Leur structure a été confirmé généralement par spectrometrie infra­rouge, par spectrométrie RMN et par spectrométrie de masse. Dans une seconde partie, nous avons évalué l'activité immunopharmacologique, de quelques un
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Gronnier, Colombe. "Développement de nouvelles réactions catalysées par l'or, l'argent ou le cuivre pour la synthèse de molécules hétérocycliques." Palaiseau, Ecole polytechnique, 2013. https://pastel.hal.science/docs/00/91/88/32/PDF/ThA_se_Colombe_Gronnier.pdf.

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Ces travaux de thèse portent principalement sur le développement de nouvelles réactions catalysées par l'or. Ce métal possède un caractère pi-acide de Lewis qui lui permet d'activer des insaturations carbonées et notamment des alcynes vis-à-vis d'attaques de nucléophiles. La variation du type d'insaturation carbonée et des propriétés du nucléophile ouvrent la voie à de nombreuses transformations. Ce manuscrit présente les nouvelles transformations qui ont été développée en choisissant des systèmes alcyne-nucléophile originaux. La réactivité d'hydroxypyridines propargyliques en présence d'un ca
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He, Shanshan. "Neglected Tropical Disease Chemotherapy: Mechanistic Characterization of Antitrypanosomal Dihydroquinolines and Development of a High Throughput Antileishmanial Screening Assay." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1337980540.

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Christadore, Lisa M. "Discovery of a small molecule dihydroquinolinone inhibitor with potent antiproliferative and antitumor activity results in catastrophic cell division." Thesis, Boston University, 2013. https://hdl.handle.net/2144/12733.

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Thesis (Ph.D.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>A family of dihydroquinolinones that inhibited the proliferation of a number of cancer cell lines and targeted the oncogenic activities of the late simian virus 40 factor (LSF) was discovered. The lead quinolin
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Rocher, Richard. "Synthèse et réactivité des 4-oxo-1, 4-Dihydroquinoléines substituées : Réactions de guanilation : Activité hypoglycémiante et inhibitrice aldose réductase." Orléans, 1998. http://www.theses.fr/1998ORLE2069.

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Le travail presente a consiste a realiser la synthese de molecules de type 4-oxo-1,4-dihydroquinoleinique susceptibles de posseder une activite hypoglycemiante et/ou inhibitrice de l'enzyme aldose reductase, qui permettraient de traiter les causes et/ou les consequences du diabete non-insulinodependant. La premiere partie de ce travail qui decrit la synthese de mono et de diacides carboxyliques a necessite l'etude de la reactivite des 4-oxo-1,4-dihydroquinoleine-3-carboxylates d'ethyle 6-substituees au travers des reactions d'alkylations regioselectives ainsi que de decarboxylations originales
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Patteux, Claudine. "Développement d'un procédé de vectorisation utilisant un vecteur de type dihydroquinoléine. Application à la vectorisation de deux neuropeptides, l'Octadécaneuropeptide (ODN) et l'Octapeptide (OP)." Rouen, INSA, 2003. http://www.theses.fr/2003ISAM0005.

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Ce travail concerne la vectorisation de deux neuropeptides, l'octadécaneuropeptide (ODN) et l'octapeptide (OP) afin de faciliter leur passage au travers de la barrière hémato encéphalique. Nous avons choisi de les lier à un vecteur dihydroquinoléinique. Dans un premier temps, nous avons envisagé de lier le vecteur au peptide selon une stratégie convergente. Nous avons étudié le greffage d'une quinoléine à un dipeptide modélisant l'ODN. Nous n'avons cependant pas pu lier le vecteur au peptide de façon sélective. La seconde stratégie repose sur l'utilisation d'une résine pré vectorisée. Nous avo
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Gronnier, Colombe, and Fabien Gagosz. "Développement de nouvelles réactions catalysées par l'or, l'argent ou le cuivre pour la synthèse de molécules hétérocycliques." Phd thesis, Ecole Polytechnique X, 2013. http://pastel.archives-ouvertes.fr/pastel-00918832.

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Ces travaux de thèse portent principalement sur le développement de nouvelles réactions catalysées par l'or. Ce métal possède un caractère pi-acide de Lewis qui lui permet d'activer des insaturations carbonées et notamment des alcynes vis-à-vis d'attaques de nucléophiles. La variation du type d'insaturation carbonée et des propriétés du nucléophile ouvrent la voie à de nombreuses transformations. Ce manuscrit présente les nouvelles transformations qui ont été développée en choisissant des systèmes alcyne-nucléophile originaux. La réactivité d'hydroxypyridines propargyliques en présence d'un ca
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Hallé, François. "Conception, développement et synthèse de ligands du TSPO dans le but de traiter les maladies neurodégénératives." Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAF054/document.

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Les neurostéroïdes sont des composés endogènes qui peuvent moduler la transmission synaptique et avoir un effet neuroprotecteur dans les maladies neurodégénératives. Les systèmes régulant leur biosynthèse ne sont pas connus mais la première étape de celle-ci peut être régulée par la protéine TSPO. Cette protéine mitochondriale facilite le transport du cholestérol vers l’intérieur de la mitochondrie pour y être métabolisé en prégnénolone. Ce stéroïde est le précurseur principal de la biosynthèse des neurostéroïdes et l’utilisation in vitro de ligands du TSPO permet d’augmenter sa sécrétion. Dan
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Oyeyiola, Felix Adetunji. "Synthesis and transformation of the 2,6,8-triaryl-2,3-dihydroquinolin-4(1H)-ones." Diss., 2011. http://hdl.handle.net/10500/5842.

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The 2-aryl-2,3-dihydroquinolin-4(1H)-ones were prepared via acid-catalyzed cyclization of the corresponding 2-aminochalcones, which were in turn, prepared by base-promoted Claisen-Schmidt aldol condensation of 2-aminoacetophenone and benzaldehyde derivatives. The 2-aryl-6,8-dibromo-2,3-dihydroquinolin-4(1H)-ones were prepared by reacting 2-aryl-2,3-dihydroquinolin-4(1H)-ones with N-bromosuccinimide (NBS) in carbon tetrachloride-chloroform mixture at room temperature. The 2-aryl-6,8-dibromo-2,3-dihydroquinolin-4(1H)-ones were subjected to palladium-catalyzed Suzuki-Miyaura cross-coupling reacti
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Book chapters on the topic "Dihydroquinoline"

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Bodanszky, Miklos, and Agnes Bodanszky. "1-Isobutyloxycarbonyl-2-isobutyloxy-1,2-dihydroquinoline (IIDQ)." In The Practice of Peptide Synthesis. Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-85055-4_33.

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Šunjić, Vitomir, and Michael J. Parnham. "1,2-Dihydroquinolines." In Signposts to Chiral Drugs. Springer Basel, 2011. http://dx.doi.org/10.1007/978-3-0348-0125-6_8.

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Meller, Emanuel, Menek Goldstein, Arnold J. Friedhoff, and Jack W. Schweitzer. "N-Ethoxycarbonyl-2-Ethoxy-1, 2-Dihydroquinoline (EEDQ): A New Tool to Probe CNS Receptor Function." In Advances in Experimental Medicine and Biology. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4899-2723-1_8.

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Chen, Y. C., and H. L. Cui. "Asymmetric Synthesis of 1,2-Dihydroquinoline-3-carbaldehydes by a Domino Michael/Aldol Reaction." In Brønsted Base and Acid Catalysts, and Additional Topics. Georg Thieme Verlag KG, 2012. http://dx.doi.org/10.1055/sos-sd-205-00583.

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Ihmels, H. "Of Dihydroquinolizine and Tetrahydroquinolizinium Derivatives." In Six-Membered Hetarenes with One Nitrogen or Phosphorus Atom. Georg Thieme Verlag KG, 2005. http://dx.doi.org/10.1055/sos-sd-015-01561.

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Larsen, R. D. "Dehydrogenation of Dihydroquinolin-4(1)-ones." In Six-Membered Hetarenes with One Nitrogen or Phosphorus Atom. Georg Thieme Verlag KG, 2005. http://dx.doi.org/10.1055/sos-sd-015-01043.

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Nekipelova, T. "Photo-induced bonding of water and alcohols to 1,2-dihydroquinolines." In Chemical kinetics. CRC Press, 2005. http://dx.doi.org/10.1201/b12072-16.

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Avendaño, C., and J. C. Menéndez. "Hydrolytic Cyclization of -(3-{2-[(5,8-Dioxo-5,8-dihydroquinolin-6-yl)amino]phenyl}-3-oxopropyl)-2,2,2-trifluoroacetamide." In Quinones and Heteroatom Analogues. Georg Thieme Verlag KG, 2006. http://dx.doi.org/10.1055/sos-sd-028-00700.

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Conference papers on the topic "Dihydroquinoline"

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Budiarto. "The effect of antioxidant concentration of N-isopropyl-N-phenyl-p-phenylenediamine, and 2,2,4-trimethyl-1,2-dihydroquinoline and mixing time of physical properties, thermal properties, mechanical properties and microstructure on natural rubber compound." In PROCEEDINGS FROM THE 14TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND. Author(s), 2017. http://dx.doi.org/10.1063/1.4978141.

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Jr., Manoel T. Rodrigues, Andre Capretz Agy, Danilo Machado Lustosa, and Fernando Coelho. "Diastereoselective synthesis of dihydroquinolines and tetrahydroquinolines from Morita Baylis-Hillman adducts." In 15th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_2013820154052.

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Javanshir, Shahrzad, and Mostafa Safari. "A new catalyst-free microwave-assisted one-pot four-component synthesis of 1,4-dihydroquinolines in aqueous media." In The 14th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2010. http://dx.doi.org/10.3390/ecsoc-14-00431.

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