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Journal articles on the topic 'Dihydroxypyrimidine'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Kufelnicki, Aleksander, Jan Jaszczak, Urszula Kalinowska-Lis, Cecylia Wardak, and Justyn Ochocki. "Complexes of Uracil (2,4-Dihydroxypyrimidine) Derivatives." Journal of Solution Chemistry 35, no. 5 (2006): 739–51. http://dx.doi.org/10.1007/s10953-006-9017-1.

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2

Powdrill, Megan H., Jerome Deval, Frank Narjes, Raffaele De Francesco, and Matthias Götte. "Mechanism of Hepatitis C Virus RNA Polymerase Inhibition with Dihydroxypyrimidines." Antimicrobial Agents and Chemotherapy 54, no. 3 (2009): 977–83. http://dx.doi.org/10.1128/aac.01216-09.

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ABSTRACT We studied the biochemical mechanisms associated with inhibition and resistance to a 4,5-dihydroxypyrimidine carboxylate that inhibits the hepatitis C virus (HCV) RNA-dependent RNA polymerase NS5B. On the basis of the structure of the pharmacophore, it has been suggested that these compounds may act as pyrophosphate (PPi) mimics. We monitored nucleotide incorporation events during the elongation phase and showed that the polymerase activity of wild-type NS5B was inhibited by the dihydroxypyrimidine at a 50% inhibitory concentration (IC50) of 0.73 μM. Enzymes with the G152E or P156L mu

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3

Shi, Daqing, Lihui Niu, and Qiya Zhuang. "Clean synthesis of pyrido[2,3-d]pyrimidines in aqueous media." Journal of Chemical Research 2005, no. 10 (2005): 648–50. http://dx.doi.org/10.3184/030823405774663048.

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The reaction of substituted cinnamonitriles and 4-amino-2,6-dihydroxypyrimidine or 2,4-diamino-6-hydroxypyrimidine in water in the presence of triethylbenzylammonium chloride (TEBA) as catalyst affords a clean synthesis of pyrido[2,3-d]pyrimidine derivatives.

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4

Rostkowska, Hanna, Anna Luchowska, Leszek Lapinski, and Maciej J. Nowak. "Photochemical transformations of 4,6-dihydroxypyrimidine and 2-methyl-4,6-dihydroxypyrimidine isolated in low-temperature Ar, Ne and H2 matrices." Chemical Physics Letters 745 (April 2020): 137263. http://dx.doi.org/10.1016/j.cplett.2020.137263.

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5

Vu, Tuan Q., Nikolai V. Yudin, Alexander A. Kushtaev, Thanh X. Nguyen, and Sergey A. Maltsev. "Spectroscopic Study of the Basicity of 4,6-Dihydroxypyrimidine Derivatives." ACS Omega 6, no. 22 (2021): 14154–63. http://dx.doi.org/10.1021/acsomega.1c00671.

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6

Kapoor, Bharat, EzzedinA Luhishi, AndrewKK Chung, and JakobusC Pauw. "Neurotrophic keratitis in a patient with dihydroxypyrimidine dehydrogenase deficiency." Indian Journal of Ophthalmology 56, no. 4 (2008): 336. http://dx.doi.org/10.4103/0301-4738.41422.

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7

Malancona, Savina, Mattia Mori, Paola Fezzardi, et al. "5,6-Dihydroxypyrimidine Scaffold to Target HIV-1 Nucleocapsid Protein." ACS Medicinal Chemistry Letters 11, no. 5 (2020): 766–72. http://dx.doi.org/10.1021/acsmedchemlett.9b00608.

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8

Boyd, Vincent A., John Mason, Parimala Hanumesh, Jeanine Price, Charles J. Russell, and Thomas R. Webb. "2-Substituted-4,5-Dihydroxypyrimidine-6-Carboxamide Antiviral Targeted Libraries." Journal of Combinatorial Chemistry 11, no. 6 (2009): 1100–1104. http://dx.doi.org/10.1021/cc900111u.

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9

Keerthi Kumar, Chinnagiri T., Jathi Keshavayya, Tantry N. Rajesh, Sanehalli K. Peethambar, and Angadi R. Shoukat Ali. "Synthesis, Characterization, and Biological Activity of 5-Phenyl-1,3,4-thiadiazole-2-amine Incorporated Azo Dye Derivatives." Organic Chemistry International 2013 (August 18, 2013): 1–7. http://dx.doi.org/10.1155/2013/370626.

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5-Phenyl-1,3,4-thiadiazole-2-amine has been synthesized by single step reaction. A series of heterocyclic azodyes were synthesized by diazotisation of 5-phenyl-1,3,4-thiadiazole-2-amine by nitrosyl sulphuric acid followed by coupling with different coupling compounds such as 8-hydroxyquinoline, 2,6-diaminopyridine, 2-naphthol, N,N-dimethyl aniline, resorcinol, and 4,6-dihydroxypyrimidine. The dyes were characterized by UV-Vis, IR, 1H-NMR, 13C NMR, and elemental analysis. The synthesized compounds were also screened for biological activity.

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10

Tang, Jing, Kasthuraiah Maddali, Yves Pommier, Yuk Y. Sham, and Zhengqiang Wang. "Scaffold rearrangement of dihydroxypyrimidine inhibitors of HIV integrase: Docking model revisited." Bioorganic & Medicinal Chemistry Letters 20, no. 11 (2010): 3275–79. http://dx.doi.org/10.1016/j.bmcl.2010.04.048.

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11

Pace, Paola, M. Emilia Di Francesco, Cristina Gardelli, et al. "Dihydroxypyrimidine-4-carboxamides as Novel Potent and Selective HIV Integrase Inhibitors." Journal of Medicinal Chemistry 50, no. 9 (2007): 2225–39. http://dx.doi.org/10.1021/jm070027u.

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12

SANJAY, SENGUPTA, and R. BANNERJEE N. "Mixed Ligand Complexes of Manganese-, Cobalt-, Nickel- ans Zinc-(II) with o-Vanillin and 4,6-Dihydroxypyrimidine in Ethanol- Water (70%) Media." Journal of Indian Chemical Society Vol, 67, April 1990 (1990): 313–15. https://doi.org/10.5281/zenodo.6139649.

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Department of Chemistry, University of Delhi, Delhi-110 007 <em>Manuscript received 5 June 1989, revised 21 September 1989, accepted 27 October 1989</em> Stability constants of mixed-ligand complexes of Mn<sup>ll</sup>, Co<sup>II</sup>, Ni<sup>II</sup> and Zn<sup>II</sup> with <em>o</em>-vanillin and 4,6-dihydroxypyrimidine (70% ethanol- water media) were calculated from polarographic data using Schaap and McMasters' method. For the Mn<sup>ll</sup> mixed-ligand complex, Crow's mean diffusion coefficient method was also used and the results compared well with that from the for

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13

Xu, Xue-Jiao, Peng Zheng, Gao-Ping Ren, et al. "2,4-Dihydroxypyrimidine is a potential urinary metabolite biomarker for diagnosing bipolar disorder." Molecular BioSystems 10, no. 4 (2014): 813. http://dx.doi.org/10.1039/c3mb70614a.

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14

de Melo, Eduardo Borges, and Márcia Miguel Castro Ferreira. "Multivariate QSAR study of 4,5-dihydroxypyrimidine carboxamides as HIV-1 integrase inhibitors." European Journal of Medicinal Chemistry 44, no. 9 (2009): 3577–83. http://dx.doi.org/10.1016/j.ejmech.2009.03.001.

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15

Shennara, Khaled A., Ray J. Butcher та Frederick T. Greenaway. "Crystal structure of tetraaquabis(pyrimidin-1-ium-4,6-diolato-κO4)manganese(II)". Acta Crystallographica Section E Crystallographic Communications 73, № 4 (2017): 620–22. http://dx.doi.org/10.1107/s2056989017004649.

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The MnIIion in the structure of the mononuclear title compound, [Mn(C4H3N2O2)2(H2O)4], is situated on an inversion center and is coordinated by two O atoms from two deprotonated 4,6-dihydroxypyrimidine ligands and by four O atoms from water molecules giving rise to a slightly distorted octahedral coordination sphere. The complex includes an intramolecular hydrogen bond between an aqua ligand and the non-protonated N ring atom. The extended structure is stabilized by intermolecular hydrogen bonds between aqua ligands, by hydrogen bonds between N and O atoms of the ligands of adjacent molecules,

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16

Metwally, Mohamed Abbas, and Hassan Ali Etman. "The Synthesis of Indeno[l,2:4,5]pyrimido[l,2-a]benzimidazole-13-ones, Indeno[l,2-b]pyrazolo[4,3-e]pyridine-3,5-dione and Related Compounds*." Zeitschrift für Naturforschung B 41, no. 4 (1986): 486–88. http://dx.doi.org/10.1515/znb-1986-0413.

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2-A rylidene-l,3-indaniones (1a and 2b ) reacts with 2-aminobenzimidazole in absolute ethanol, to yield 12,12a-dihydro-12-aryl-13H̱-indeno[1̄,2̄̄̄:4,5]pyrim ido[1,2-a̱]benzimidazole-13-one (2a and 2b). Treatm ent of 2a with PPA gave 15aH̱ -dibenzo[2̄,3̄:4̄,5̄]pentaleno[1̄,6̄:4,5,6]pyrimido- [1,2-a̱]benzimidazole (5). While the condensation of 1c with 3-amino-1-phenyl-2-pyrazolin-5-one in benzene in the presence of PTSA afforded 4-(2-hydroxyphenyl)-2,3a,4,4a-tetrahydro-2-phenylindeno[ 1,2-ḇ]pyrazolo[4,3-e̱]pyridine-3,5-dione (6a). However, the condensation of la with 2-amino-4,6-dihydroxypyrim

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17

Otutu, O. J., and A. K. Asiagwu. "Synthesis and Application to Polyester and Nylon 6 Fabrics of Hetaryl Bis-Azo Disperse Dyes Based on 6-Amino-2,4-Dihydroxypyrimidine and 4-Methoxy-2-Nitroaniline Moieties." Journal of Scientific Research 11, no. 2 (2019): 215–24. http://dx.doi.org/10.3329/jsr.v11i2.38734.

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Six new bis-azo disperse dyes were synthesized by linking various aryl amino and hydroxyl derivatives to 4-methoxy-2-nitroaniline and 6-amino-2,4-dihydroxypyrimidine moieties through diazo coupling reactions. The structures of the bis-azo dyes were identified by Fourier transform infrared, proton and carbon 13 nuclear magnetic resonance data. The prepared dyestuffs were applied onto polyester and nylon 6 fabrics and subsequently their fastness properties in terms of light, washing, sublimation and rubbing were determined. Compared with the light fastness of polyester fabrics, the light fastnes

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18

Boyle, Timothy J., Mark A. Rodriguez, and Todd M. Alam. "4,6-Dihydroxypyrimidine: a selective bridging ligand for controlled Group IV metal alkoxide structures." Dalton Transactions, no. 24 (2003): 4598. http://dx.doi.org/10.1039/b310087a.

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19

Pacini, Barbara, Salvatore Avolio, Caterina Ercolani, et al. "2-(3-Thienyl)-5,6-dihydroxypyrimidine-4-carboxylic acids as inhibitors of HCV NS5B RdRp." Bioorganic & Medicinal Chemistry Letters 19, no. 21 (2009): 6245–49. http://dx.doi.org/10.1016/j.bmcl.2009.06.106.

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20

MOSKVIN, A. V., N. M. PETROVA, E. A. SEMENOVA, M. SHOPOVA, V. A. GINDIN, and B. A. IVIN. "ChemInform Abstract: Azines and Azoles. Part 88. Condensation of 4,6-Dihydroxypyrimidine with Aromatic Aldehydes." ChemInform 25, no. 27 (2010): no. http://dx.doi.org/10.1002/chin.199427164.

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21

Karen, Pavel, Richard L. Harlow, Zhigang Li, et al. "The Crystal Structure of 2-Amino-4,6-dihydroxypyrimidine Determined from Powder X-Ray Synchrotron Diffraction." Acta Chemica Scandinavica 52 (1998): 1051–55. http://dx.doi.org/10.3891/acta.chem.scand.52-1051.

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22

He, Tianyu, Tiffany C. Edwards, Jiashu Xie, Hideki Aihara, Robert J. Geraghty, and Zhengqiang Wang. "4,5-Dihydroxypyrimidine Methyl Carboxylates, Carboxylic Acids, and Carboxamides as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease." Journal of Medicinal Chemistry 65, no. 7 (2022): 5830–49. http://dx.doi.org/10.1021/acs.jmedchem.2c00203.

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23

Yazdanbakhsh, M. R., H. Yousefi, M. Mamaghani, et al. "Synthesis, spectral characterization and antimicrobial activity of some new azo dyes derived from 4,6-dihydroxypyrimidine." Journal of Molecular Liquids 169 (May 2012): 21–26. http://dx.doi.org/10.1016/j.molliq.2012.03.003.

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24

Petrocchi, Alessia, Uwe Koch, Victor G. Matassa, Barbara Pacini, Kara A. Stillmock, and Vincenzo Summa. "From dihydroxypyrimidine carboxylic acids to carboxamide HIV-1 integrase inhibitors: SAR around the amide moiety." Bioorganic & Medicinal Chemistry Letters 17, no. 2 (2007): 350–53. http://dx.doi.org/10.1016/j.bmcl.2006.10.054.

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25

Muhammad, Munira Taj, Khalid Mohammed Khan, Arshia, et al. "Syntheses of 4,6-dihydroxypyrimidine diones, their urease inhibition, in vitro, in silico, and kinetic studies." Bioorganic Chemistry 75 (December 2017): 317–31. http://dx.doi.org/10.1016/j.bioorg.2017.08.018.

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26

Wang, Kuan, Jian-Gang Chen, Bozhou Wang, et al. "Insight into the acidic group-induced nitration mechanism of 2-methyl-4,6-dihydroxypyrimidine (MDP) with nitronium." RSC Advances 6, no. 83 (2016): 80145–57. http://dx.doi.org/10.1039/c6ra18842g.

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27

Krishnakumar, V., and N. Prabavathi. "DFT simulations and vibrational analysis of FTIR and FT-Raman spectra of 2-amino-4,6-dihydroxypyrimidine." Journal of Raman Spectroscopy 39, no. 5 (2008): 679–84. http://dx.doi.org/10.1002/jrs.1916.

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28

Hao, Xinyu, Ying Wang, Lei Guan, and Yuting Guo. "Four N-heterocyclic carboxylate-phenolate coordination compounds: Syntheses, structures, and fluorescent properties." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 35, no. 01 (2025): 25. https://doi.org/10.59467/ijhc.2025.35.25.

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Four coordination compounds, Ca(dhpmca)2(H2O)3 (1), M(dhpmca)2(H2O)2 (M = Mg (2), Mn (3)) and Cu(dhpmca)(phen)(H2O).NO3.H2O (4) (Hdhpmca = 2,4-dihydroxypyrimidine-5-carboxylic acid, phen = 1,10-phenanthroline), were synthesized and structurally characterized. The structure analyses showed that compounds 1-4 feature mononuclear structures, where dhpmca- anions adopt carboxylate and phenolate groups to bind to metal centers in monodentate fashions. The other coordinated sites are occupied by the oxygen atoms from water molecules and the nitrogen atoms from phen molecules. In addition, compounds

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29

Xiao, Bo, and et al. "Crystal structure of aqua-[(2,2’-bipyridine)]-[(2,4-dihydroxypyrimidine- 5-carboxylato)] perchloratocopper(II), Cu(H2O)(C10H8N2)(C5H3N2O4)(ClO4), C15H13ClCuN4O9." Zeitschrift für Kristallographie - New Crystal Structures 227, no. 3 (2012): 365–66. http://dx.doi.org/10.1524/ncrs.2012.0176.

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30

Hoti, Ramiz, Hamit Ismaili, Veprim Thaçi, Gjyle Mulliqi-Osmani, Malësore Pllana-Zeqiri, and Agon Bytyqi. "An Efficient Synthesis of Novel 3-[(Heteroaryl-2-ylimino)-methyl]-4-hydroxy-chromen-2-ones and Analogue of Tetrazole Derivatives and Their Antibacterial Activity." Molbank 2021, no. 4 (2021): M1303. http://dx.doi.org/10.3390/m1303.

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Synthesis of a series of the substituted [(pyridinyl and pyrimidin-2-ylimino)-ethyl]-4-hydroxy-chromen-2-ones and their tetrazole derivates is presented in this study. By catalytic condensation of 4-hydroxy-3-acetylcoumarine 2 and 2-aminopyridines 3(a-d), 3-[(pyridin-2-ylimino)-ethyl]-4-hydroxy-chromen-2-ones 4(a-d) are synthesized in high yield. During the condensation reaction of 2 and 4-amino-2,6-dihydroxypyrimidine 3e, 3-[1-(2,6-Dihydroxy-pyrimidin-4-ylimino)-ethyl]-4-hydroxy-chromen-2-one 4e as condensation products is synthesized. In following series, by cyclization reactions of compound

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31

Stansfield, Ian, Salvatore Avolio, Stefania Colarusso, et al. "Active site inhibitors of HCV NS5B polymerase. The development and pharmacophore of 2-thienyl-5,6-dihydroxypyrimidine-4-carboxylic acid." Bioorganic & Medicinal Chemistry Letters 14, no. 20 (2004): 5085–88. http://dx.doi.org/10.1016/j.bmcl.2004.07.075.

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32

Guo, Yuting, Xinyu Hao, Ying Wang, and Lei Guan. "Syntheses, Structures, and Properties of Five Coordination Compounds Based N-Heterocyclic Ligands." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 34, no. 02 (2024): 229. http://dx.doi.org/10.59467/ijhc.2024.34.229.

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Five coordination compounds based on 2,6-dihydroxypyrimidine-4-carboxylic acid (H3pymca), Ni2(Hpymca)2(bipy)(H2O)6?2H2O (1), Co2(Hpymca)2(bipy)(H2O)6?2H2O (2), Ni(Hpymca)(pya)(H2O)2 (3), Zn(Hpymca)(pyrapyri)(H2O)?H2O (4), and [Ba(H2pymca)2]n (5) (bipy = 4,4'-bipyridine, pya = pyridine-2-aldoxime, pyrapyri = 2-(1H-pyrazol-3-yl)pyridine) have been synthesized by hydrothermal methods and structurally characterized. The structure analyses showed that compounds 1 and 2 are isostructural with triclinic, P-1 space group, where the bipy molecule bridges with two metal ions, and Hpymca2- anions serve a

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33

Summa, Vincenzo, Alessia Petrocchi, Victor G. Matassa, et al. "4,5-Dihydroxypyrimidine Carboxamides andN-Alkyl-5-hydroxypyrimidinone Carboxamides Are Potent, Selective HIV Integrase Inhibitors with Good Pharmacokinetic Profiles in Preclinical Species." Journal of Medicinal Chemistry 49, no. 23 (2006): 6646–49. http://dx.doi.org/10.1021/jm060854f.

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34

Li, Xianghong, Shuduan Deng, Xiaoguang Xie, and Guanben Du. "Synergistic inhibition effect of 5-aminotetrazole and 4,6-dihydroxypyrimidine on the corrosion of cold rolled steel in H 3 PO 4 solution." Materials Chemistry and Physics 181 (September 2016): 33–46. http://dx.doi.org/10.1016/j.matchemphys.2016.06.031.

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35

Summa, Vincenzo, Alessia Petrocchi, Victor G. Matassa та ін. "HCV NS5b RNA-Dependent RNA Polymerase Inhibitors: From α,γ-Diketoacids to 4,5-Dihydroxypyrimidine- or 3-Methyl-5- hydroxypyrimidinonecarboxylic Acids. Design and Synthesis". Journal of Medicinal Chemistry 47, № 22 (2004): 5336–39. http://dx.doi.org/10.1021/jm0494669.

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36

Festus, Chioma, and D. Don-Lawson Chioma. "Synthesis, spectral, magnetic and in-vitro biological studies of organic ligands and their corresponding heteroleptic divalent d-metal complexes." Pharmaceutical and Chemical Journal 5, no. 3 (2018): 118–29. https://doi.org/10.5281/zenodo.13909425.

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Novel heteroleptic Co(II) and Zn(II) complexes of a Schiff base derived from 2-amino-4,6-dihydroxypyrimidine and 2-hydroxy-1-napthaldehyde were synthesized and characterized by percentage metal  and elemental (CHN) analyses, FTIR, UV-VIS and <sup>1</sup>H- and <sup>13</sup>C-NMR spectroscopies, magnetic susceptibility, melting point and molar conductance measurements. The proposed molecular formula [M(L)(L’)OAc] {M= Co and Zn; L=Schiff base and L’= 2,2’-Bipyridine} for the complexes were consistent with the  spectral, elemental and  percentage metal  data.

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37

Li, Xin-yang, Jing-wei Liang, Kamara Mohamed O, Ting-jian Zhang, Guo-Qing Lu, and Fan-hao Meng. "Design, synthesis and biological evaluation of N-phenyl-(2,4-dihydroxypyrimidine-5-sulfonamido)benzoyl hydrazide derivatives as thymidylate synthase (TS) inhibitors and as potential antitumor drugs." European Journal of Medicinal Chemistry 154 (June 2018): 267–79. http://dx.doi.org/10.1016/j.ejmech.2018.05.020.

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38

Kobayashi, Satoshi, Makoto Ueno, Gakuto Ogawa, et al. "Impact of renal function on the efficacy and safety of S-1 with concurrent radiotherapy for locally advanced pancreatic cancer." Journal of Clinical Oncology 37, no. 4_suppl (2019): 301. http://dx.doi.org/10.1200/jco.2019.37.4_suppl.301.

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301 Background: S-1 is an oral agent consisting of a mixture of tegafur which is a prodrug of 5-fluorouracil (5-FU), 5-chloro-2,4-dihydroxypyrimidine (DHP) and potassium oxonate. Serum concentration of 5-FU increases in case of renal dysfunction due to decrease of DHP excretion into urine. The aim of this study was to evaluate the influence of renal function to the efficacy and safety of S-1 with concurrent radiotherapy (RT) for locally advanced pancreatic cancer (LAPC). Methods: This study was an integrated exploratory analysis of JCOG1106 and LAPC- S1RT, in which pts with LAPC received RT (5

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39

Guo, Di-Liang, Xing-Jie Zhang, Rui-Rui Wang, et al. "Structural modifications of 5,6-dihydroxypyrimidines with anti-HIV activity." Bioorganic & Medicinal Chemistry Letters 22, no. 23 (2012): 7114–18. http://dx.doi.org/10.1016/j.bmcl.2012.09.070.

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40

Zhang, Xiao-Min, Hui-Liang Zhou, and Qi-Lin Hu. "N-(2-Amino-4,6-dihydroxypyrimidin-5-yl)acetamide dihydrate." Acta Crystallographica Section E Structure Reports Online 67, no. 9 (2011): o2526. http://dx.doi.org/10.1107/s1600536811034441.

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41

Ofitserova, E. S., A. A. Shklyarenko, I. P. Yakovlev, and E. V. Fedorova. "Vilsmeier–Haack formylation of ethyl [(4,6-dihydroxypyrimidin-2-yl)sulfanyl]acetate." Russian Journal of Organic Chemistry 52, no. 9 (2016): 1374–76. http://dx.doi.org/10.1134/s1070428016090256.

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42

Novais, H. M., and S. Steenken. "Reactions of oxidizing radicals with 4,6-dihydroxypyrimidines as model compounds for uracil, thymine, and cytosine." Journal of Physical Chemistry 91, no. 2 (1987): 426–33. http://dx.doi.org/10.1021/j100286a034.

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43

Telvekar, Vikas N., and Kavitkumar N. Patel. "Pharmacophore Development and Docking Studies of the HIV-1 Integrase Inhibitors Derived from N-methylpyrimidones, Dihydroxypyrimidines, and Bicyclic Pyrimidinones." Chemical Biology & Drug Design 78, no. 1 (2011): 150–60. http://dx.doi.org/10.1111/j.1747-0285.2011.01130.x.

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44

Astrat'ev, A. A., D. V. Dashko, A. Yu Mershin, A. I. Stepanov, and N. A. Urazgil'deev. "ChemInform Abstract: Some Specific Features of Acid Nitration of 2-Substituted 4,6-Dihydroxypyrimidines. Nucleophilic Cleavage of the Nitration Products." ChemInform 32, no. 51 (2010): no. http://dx.doi.org/10.1002/chin.200151070.

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45

Winterbourn, Christine C., and Rex Munday. "Concerted Action Of Reduced Glutathione And Superoxide Dismutase In Preventing Redox Cycling Of Dihydroxypyrimidines, And Their Role In Antioxidant Defence." Free Radical Research Communications 8, no. 4-6 (1990): 287–93. http://dx.doi.org/10.3109/10715769009053361.

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46

Jansa, Petr, Antonín Holý, Martin Dračínský, et al. "5-Substituted 2-amino-4,6-dihydroxypyrimidines and 2-amino-4,6-dichloropyrimidines: synthesis and inhibitory effects on immune-activated nitric oxide production." Medicinal Chemistry Research 23, no. 10 (2014): 4482–90. http://dx.doi.org/10.1007/s00044-014-1018-9.

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47

Cushman, Mark, Jeffrey T. Mihalic, Klaus Kis, and Adelbert Bacher. "Design and synthesis of 6-(6-D-ribitylamino-2,4-dihydroxypyrimidin-5-yl)-1-hexylphosphonic acid, a potent inhibitor of lumazine synthase." Bioorganic & Medicinal Chemistry Letters 9, no. 1 (1999): 39–42. http://dx.doi.org/10.1016/s0960-894x(98)00687-8.

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Cushman, Mark, Jeffrey T. Mihalic, Klaus Kis, and Adelbert Bacher. "ChemInform Abstract: Design and Synthesis of 6-(6-D-Ribitylamino-2,4-dihydroxypyrimidin-5-yl)-1-hexylphosphonic Acid, a Potent Inhibitor of Lumazine Synthase." ChemInform 30, no. 19 (2010): no. http://dx.doi.org/10.1002/chin.199919169.

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Festus, Chioma, Anthony C. Ekennia, Aderoju A. Osowole, Lukman O. Olasunkanmi, Damian C. Onwudiwe, and Oguejiofo T. Ujam. "Synthesis, experimental and theoretical characterization, and antimicrobial studies of some Fe(II), Co(II), and Ni(II) complexes of 2-(4,6-dihydroxypyrimidin-2-ylamino)naphthalene-1,4-dione." Research on Chemical Intermediates 44, no. 10 (2018): 5857–77. http://dx.doi.org/10.1007/s11164-018-3460-7.

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Novais, H. M., and S. Steenken. "ESR studies of electron and hydrogen adducts of thymine and uracil and their derivatives and of 4,6-dihydroxypyrimidines in aqueous solution. Comparison with data from solid state. The protonation at carbon of the electron adducts." Journal of the American Chemical Society 108, no. 1 (1986): 1–6. http://dx.doi.org/10.1021/ja00261a001.

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