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Dissertations / Theses on the topic 'Diseases of gastrointestinal tract'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

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1

Nijhuis, Anke. "Roles of microRNAs in diseases of the human gastrointestinal tract." Thesis, Queen Mary, University of London, 2015. http://qmro.qmul.ac.uk/xmlui/handle/123456789/9547.

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Crohn's disease (CD) and colorectal cancer (CRC) are major disorders of the intestine. Inflammation in CD often precedes fibrosis and stricture formation, and is linked to increased cancer risk. Hypoxia is a common feature of inflammation and CRC that can severely compromise the effectiveness of current therapy regimes including chemo-radiotherapy and maintenance of remission in CD patients. MicroRNAs (miRNAs) are key regulatory molecules involved in cellular proliferation, apoptosis and fibrosis, which are all modulated by hypoxia. This thesis aims to understand the role of miRNAs in these tw

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2

Revitt, David. "Characterization of a haemolysin from Serpulina hyodysenteriae." Thesis, University of Reading, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333432.

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3

Lozyuk, I. Ya. "Frequency of Helicobacter pylori infection in children with inflammatory diseases of the gastrointestinal tract." Thesis, БДМУ, 2022. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19770.

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4

Flynn, Elaine Rose Maria. "Ionic conductances involved in the electrical activity of the canine gastrointestinal tract /." abstract and full text PDF (UNR users only), 1999. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:9934138.

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5

Campbell, Stewart. "Metabolic interactions between alcohol, the liver and the gastrointestinal tract." Thesis, University of Glasgow, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248184.

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6

Dinis, João Vitor Barrau Mendes Ferreira. "Estratégias nutricionais na prevenção de doenças digestivas dos suínos." Bachelor's thesis, Universidade Técnica de Lisboa. Faculdade de Medicina Veterinária, 2010. http://hdl.handle.net/10400.5/2573.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>Depois da proibição do uso de promotores de crescimento em produção animal pela União Europeia em 2003, a suinicultura deparou-se com uma série de doenças que anteriormente estavam suprimidas, nomeadamente a nível do tracto gastrointestinal, devido à incorporação consecutiva de promotores de crescimento, ou seja, antibióticos nos alimentos compostos. Os actuais sistemas de produção de suínos têm um impacto importante nas funções, na integridade e na saúde do seu tubo digestivo, havendo uma diversidade de factores que a podem prejudic

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7

Kondratska, N., A. Yusupova, Ірина Іванівна Школьна, Ирина Ивановна Школьная, and Iryna Ivanivna Shkolna. "Clinical-endoscopic features and effectiveness of treatment of chronic diseases of the gastrointestinal tract in children." Thesis, Sumy State University, 2020. https://essuir.sumdu.edu.ua/handle/123456789/81182.

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Метою дослідження було вивчення клініко-ендоскопічних особливостей та ефективності лікування хронічних захворювань шлунково-кишкового тракту у дітей. Лікування хворих на хронічний гастродуоденіт, виразку шлунку та дванадцятипалої кишки повинно бути комплексним. Реабілітаційна терапія позитивно впливає на функцію пошкодженого органу та систем, що призводить до тривалої морфологічної ремісії хронічного гастродуоденіту, виразки шлунку та дванадцятипалої кишки.<br>The aim of the study was to study clinical-endoscopic features and effectiveness of treatment of chronic diseases of the gastrointestin

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8

Brooke, Matthew A. "The genetic and functional basis of three inherited cutaneous and gastrointestinal diseases in humans." Thesis, Queen Mary, University of London, 2014. http://qmro.qmul.ac.uk/xmlui/handle/123456789/7932.

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This thesis describes investigations into the genetic basis and pathophysiology of three distinct inherited diseases in humans, two of which are strongly associated to the function of the ectodomain sheddase enzyme ADAM17. The first of these is a novel inherited syndrome of neonatal onset inflammatory skin and bowel disease, which is associated in a consanguineous family with homozygous loss-offunction mutations in ADAM17. This thesis describes investigations of the expression and function of ADAM17 – and downstream proteins it regulates – in an individual affected by this disease. This is acc

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9

Usselmann, Bernhard M. "The involvement of telomerase in malignant and inflammatory disease of the gastrointestinal tract." Thesis, University of Warwick, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246747.

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10

Fintl, Constanze. "The interstitial cells of Cajal of the equine gastrointestinal tract : development and disease." Thesis, University of Edinburgh, 2005. http://hdl.handle.net/1842/29758.

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Using immunohistochemistry targeting a receptor tyrosine kinase, c-Kit, of the ICC, the ontogeny of these cells in the horse was described. This demonstrated a proximal to distal, as well as a transmural developmental gradient in the large intestine with evidence of ongoing postnatal development. Additionally, the density of ICC in healthy, adult horses was compared to that in horses with obstructive intestinal disease requiring surgical correction. This demonstrated a significant reduction in ICC density in horses with obstructive disorders of the large intestine compared to the control group

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11

Wilson, Nicola Lindsay. "An investigation of differential gene expression and antibody variable sequences in inflammatory bowel disease." Thesis, Glasgow Caledonian University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364777.

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12

Vieten, Daniela. "Musocal protection during human foetal gastrointestinal tract ontogeny and in neonatal intestine in health and disease." Thesis, University of Bristol, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.601165.

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Background Necrotising enterocolitis (NEe) remains a leading cause of mortality in neonatal intensive care units. There is currently a poor understanding of the molecular mechanisms underlying the pathogenesis of NEC and a lack of effective treatment strategies. Studies performed by various groups suggest that intestinal barrier failure plays a critical role in the development of NEC. The intestinal mucosal barrier is a complex defence system against the onslaught of noxious substances within the lumen, while allowing the influx of nutrients. Mucin glycoproteins and trefoil factor family (TFF)

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13

Junginger, Johannes [Verfasser]. "Dendritic cells and regulatory T cells in the gastrointestinal tract of healthy and diseased dogs with inflammatory bowel disease / Johannes Junginger." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2013. http://d-nb.info/1037832264/34.

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14

Bloom, Stuart. "Adhesion molecules in the gastrointestinal tract : a search for cell surface molecules upregulated in inflammatory bowel disease." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239338.

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15

Martins, Tessie Beck. "MORFOLOGIA COMPARADA DA PITIOSE EM CAVALOS, CÃES E BOVINOS." Universidade Federal de Santa Maria, 2010. http://repositorio.ufsm.br/handle/1/10083.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Twenty-one cases of pythiosis involving horses (10), dogs, (nine) and cattle (2) were investigated. In all of them the etiology was confirmed through immunohistochemistry technique. Data related to clinical course, localization and macroscopic features of the lesions and cases closure were obtained from biopsies and necropsies protocols. For compared histomorphological and histochemical characterization, hematoxilin-eosin, Grocott‟s, Schiff periodic acid, sirius red and Grocott-Sirius red techiques were performed. The aspects analy

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16

Bunce, Keith Thomas. "The development of novel compounds for the treatment of disease and the elucidation of function in the gastrointestinal tract." Thesis, University of Newcastle upon Tyne, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.445634.

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17

Greathead, Louise. "The role of TH17 cells in the gastrointestinal tract of patients with HIV-1 infection and Inflammatory Bowel Disease." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/24834.

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Increased levels of systemic immune activation are strongly associated with disease progression in HIV-1 infection, but the mechanisms causing it are not well understood. This work investigated the TH17 subset in the gastrointestinal tract of HIV-1 infected patients and looked for evidence that mucosal barrier breaches and microbial translocation contribute to peripheral immune activation. We found significant disruption in the expression of mucosal tight junction proteins in HIV-1 infection that only partially resolved on ART. This mucosal damage was positively correlated to plasma HIV viral

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18

Кириченко, Наталія Миколаївна, Наталия Николаевна Кириченко, Nataliia Mykolaivna Kyrychenko та М. В. Прокопішек. "Аналіз поширеності та захворюваності хворобами органів травлення в Сумській області". Thesis, Сумський державний університет, 2015. http://essuir.sumdu.edu.ua/handle/123456789/41411.

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Хвороби органів травлення (ХОТ) є серйозною проблемою в Україні, які займають 3- тє місце у структурі хронічної захворюваності населення країни, 5-те – у структурі причин госпіталізації та смерті, 7-ме та 8-ме – у структурі первинного виходу на інвалідність та тимчасової непрацездатності відповідно.

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19

Góngora, Benítez Miriam. "New Orthogonal Strategies for Peptide Synthesis." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/104532.

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Synthesis of Cys-containing peptides has long been posed as an attractive challenge for peptide chemist. Protecting groups for the nucleophilic beta-thiol group of Cys residues must be stable during peptide elongation, and can be removed under mild conditions when necessary. Synthesis of peptides with multiple-disulfide bonds frequently demands the implementation of additional orthogonal dimensions into the protection schemes. Therefore, combinations of orthogonal and/or compatible protecting groups for each pair of Cys residues enable the regioselective formation of disulfide bridges. The dev

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20

Hyseni, Besmir. "THE ROLE OF IMMUNE CELLS IN TRANSPORT OF CHLAMYDIA MURIDARUM FROM THE ILIAC LYMPH NODES TO THE SPLEEN AND THE GASTROINTESTINAL TRACT." OpenSIUC, 2021. https://opensiuc.lib.siu.edu/theses/2836.

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Chlamydia trachomatis is the most common sexually transmitted bacterial pathogen worldwide. Chlamydia spp. infect epithelial cells of the respiratory, intestinal, and reproductive tracts. Chlamydial infections in women may lead to pelvic inflammatory disease, ectopic pregnancy, chronic pelvic pain, and infertility. In addition to infecting infection the female reproductive tract (FRT), Chlamydia also infects the gastrointestinal tract (GIT) of animals and humans. In mice Chlamydia muridarum disseminates from the FRT to the GIT via internal routes and in a stepwise manner. Initially Chlamydia s

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21

Locher, Maria Christine Theresia. "Distribution of mast cells and expression of IgE protein and mRNA for IgE and IL-4 in the gastrointestinal tract of dogs affected with inflammatory bowel disease /." [S.l.] : [s.n.], 1999. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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22

Бабінець, Антоніна Миколаївна, Сергій Віталійович Попов, Сергей Витальевич Попов, Serhii Vitaliiovych Popov, Антонина Николаевна Бабинец та Antonina Mykolaivna Babinets. "Частота виникнення захворювань ШКТ залежно від виду вигодовування". Thesis, Видавництво СумДУ, 2009. http://essuir.sumdu.edu.ua/handle/123456789/5675.

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Дослідження здійснювалося на базі Сумської Міської Клінічної лікарні, об׳єктом дослідження були 110 історій хвороб пацієнтів, які знаходилися на стаціонарному лікуванні в період з 9.09.08 по 10.01.09. Дослідні групи складали пацієнти віком від 10 до 16 років. При цитуванні документа, використовуйте посилання http://essuir.sumdu.edu.ua/handle/123456789/5675

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23

Batista, Lobo Samira. "Development of 'In vitro' intestinal models to study the pharmacology of drugs affecting the gastrointestinal tract in normal and diseased conditions. Development of a cell culture model for intestinal pharmacology." Thesis, University of Bradford, 2009. http://hdl.handle.net/10454/4295.

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Studies investigating the effect of 5-HT receptors mediating a response in the neonatal intestine have been limited. There are evidences that the development of new neurones continues past postnatal term and this suggests that receptors expression may differ during maturation. Thus, 'in vitro' experiments were carried out to investigate the effects of ACh, atropine, 5-HT and its related drugs on intact intestinal segments taken from the ileum of adult and neonate rats. The application of ACh (3nM-1mM) and 5-HT (3nM-1mM) induced contractions in a concentration dependent manner in all tissues ex

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24

Georghiades, Alicia. "Incongruent Views of Quality of Life between Patients and Physicians: A Mixed-Methods Enquiry." Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/673738.

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Functional gastrointestinal disorders (FGIDs) continue to be the most common disorders treated in gastroenterological practice. They are associated with higher levels of psychological distress, impaired quality of life and increased healthcare use. The main objective of the current thesis was to evaluate the level of discrepancy (i.e., incongruence) between patients and physicians quality of life, as well as the effect this has on psychological distress, physician satisfaction and quality of life. More specifically, we explored the effect of incongruence in a primary care settin

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25

Дорожинська, В. Ю. "Якість життя та стан вегетативної нервової системи у хворих на артеріальну гіпертензію з коморбідними кислотозалежними захворюваннями шлунково-кишкового тракту". Thesis, Сумський державний університет, 2017. http://essuir.sumdu.edu.ua/handle/123456789/55396.

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Мета: Оцінити якість життя та стан автономної нервової системи у хворих на неускладнену артеріальну гіпертензію (АГ) в залежності від наявності супутнього кислото залежного захворювання(КЗЗ) шлунково-кишкового тракту (ШКТ).

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26

Brink, Gijs Robert van den. "Morphostasis of the adult gastrointestinal tract." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2002. http://dare.uva.nl/document/85925.

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27

Macadam, Anglea Brenda. "Drug targeting in the gastrointestinal tract." Thesis, University of Brighton, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306400.

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28

Dahlhoff, Maik. "Actions of betacellulin in the gastrointestinal tract." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-98465.

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29

Forster, Eliot Richard. "Neuroendocrine control in the upper gastrointestinal tract." Thesis, University of Liverpool, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316600.

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30

Price, Kenneth J. "Nitric oxide in the rat gastrointestinal tract." Thesis, Aston University, 1997. http://publications.aston.ac.uk/10937/.

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This study concerns the nature of nitric oxide synthase (NOS) and the role of nitric oxide (NO) in the rat gastrointestinal tract. The major objectives were (i) to characterise NOS isoforms in the gastric glandular mucosa, (ii) to localise NOS isoforms in the rat gastric glandular mucosa, (iii) to investigate the role of NO in carbachol-stimulated gastric mucus secretion, (iv) to investigate the nature of NOS and small intestine. Immunoblotting was performed using polyclonal antisera raised against two peptides found in the rat brain NOS sequence and commercial monoclonal antibodies directed a

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31

Njuguna, Peter. "Studies on the manipulation of gastrointestinal tract bacteria." Access electronically, 2005. http://www.library.uow.edu.au/adt-NWU/public/adt-NWU20060719.125402/index.html.

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32

Eeden, Susanne van. "Endocrine tumors of the pancreas and gastrointestinal tract." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2005. http://dare.uva.nl/document/78589.

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33

Hunter, Andrew C. "Mucus and mucosal bicarbonate in the gastrointestinal tract." Thesis, University of Newcastle Upon Tyne, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329426.

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34

Ventayol-García, Tania. "Clonal expansion in the human upper gastrointestinal tract." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8694.

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The high incidence of gastrointestinal cancers in the general population and the presence of premalignant dysplastic precursor lesions in the gastrointestinal tract make the gastrointestinal tract an ideal environment to study cancer clonality and clonal expansion. Background: Intestinal metaplastic (IM) glands in the human stomach are clonal, contain multiple stem cells and spread by fission. This mechanism of gland fission causes field cancerisation. We hypothesised that gastric adenocarcinoma (GA) progresses through a series of genetic events arising from a founder mutation. A process analo

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35

Williams, Julie M. "Aspects of signal transduction in the gastrointestinal tract." Thesis, Aston University, 1994. http://publications.aston.ac.uk/12504/.

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This study was undertaken to increase knowledge of the mechanisms of inter- and intracellular signalling in the gastrointestinal tract. Specific aims were: to use cell lines to elucidate factors affecting growth of gastric cells, to investigate the distribution and aspects of function of isoforms of protein kinase C in a gastric cell line and in the rat gastrointestinal tract and to determine the presence and regulation of nitric oxide synthase in gastrointestinal tissues from the rat and in cell lines. The gastric cancer cell line HGT-1 was used to investigate control of growth. Increases in

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36

Dias, Juliana. "Characterizing the gastrointestinal tract microbiota of dairy calves." Universidade Federal de Viçosa, 2017. http://www.locus.ufv.br/handle/123456789/13065.

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Submitted by Marco Antônio de Ramos Chagas (mchagas@ufv.br) on 2017-11-14T12:59:59Z No. of bitstreams: 1 texto completo.pdf: 3045284 bytes, checksum: 75fae3d40e3e0a912a8276323170df28 (MD5)<br>Made available in DSpace on 2017-11-14T12:59:59Z (GMT). No. of bitstreams: 1 texto completo.pdf: 3045284 bytes, checksum: 75fae3d40e3e0a912a8276323170df28 (MD5) Previous issue date: 2017-02-22<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Ao nascimento, os bezerros exibem um trato gastrointestinal subdesenvolvido (TGI) cuja maturação é estritamente relacionada à colonização da mi

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37

Hägebarth, Andrea. "Brk tyrosine kinase signaling in the gastrointestinal tract." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2005. http://dx.doi.org/10.18452/15379.

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Die Tyrosin Kinase Brk stellt den Prototypen nicht N-terminal myristoylierter, Nicht-Rezeptor Tyrosin Kinasen dar. Die Expression dieser Kinase ist auf epitheliale Gewebe beschränkt und wird während der Entwicklung differentiell reguliert. In normalen Geweben ist die Brk Expression auf nichtproliferierende, terminal differenzierte Zellen beschränkt. Um die regulatorische Funktion von Brk im murinen Darmepithel zu untersuchen, wurde das brk Gen in der Maus inaktiviert. Brk knockout Mäuse zeigten keine offensichtlichen Defekte in ihrer Entwicklung jedoch eine erweiterte Proliferationszone in den

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38

Johns, Catharine Emma. "Expression of glycosylated TFF2 in the upper gastrointestinal tract." Thesis, University of Newcastle upon Tyne, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405073.

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Dhaliwal, Winnie. "Expression and regulation of defensins in the gastrointestinal tract." Thesis, Queen Mary, University of London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420406.

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Moncur, Peter Harrigan. "Trefoil peptides : key effector proteins in the gastrointestinal tract." Thesis, University of Leeds, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415604.

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41

Morton, Magda Francesca. "Characterisation of cholecystokinin receptors in the human gastrointestinal tract." Thesis, King's College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271402.

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Kelly, John. "Pharmacological characterisation of alpha-adrenoceptors in the gastrointestinal tract." Thesis, Glasgow Caledonian University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377912.

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43

Abramson, Alex Gilbert. "Ingestible capsules for therapeutic injections in the gastrointestinal tract." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/122845.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemical Engineering, 2019<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 189-201).<br>Macromolecule drugs such as insulin have transformed our capacity to effectively treat diseases; however, their rapid degradation and poor absorption in the gastrointestinal (GI) tract generally limits their administration to parenteral routes. An oral biologic delivery system must aid in both localization and permeation to achieve systemic drug uptake. In this thesis I will describe two oral capsules

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44

El-Kadi, Samer Wassim. "Regulation of macronutrient metabolism by the gastrointestinal tract of ruminants." College Park, Md. : University of Maryland, 2006. http://hdl.handle.net/1903/3814.

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Thesis (Ph. D.) -- University of Maryland, College Park, 2006.<br>Thesis research directed by: Animal Sciences. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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45

Askoura, Momen Mahmoud Ez ElArab Abd ElAziz M. "Acid Adaptive Mechanisms of Campylobacter jejuni in the Gastrointestinal Tract." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32108.

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Campylobacter jejuni is a prevalent cause of bacterial gastroenteritis in humans worldwide. The mechanism by which C. jejuni survives stomach acidity remains unknown. In this study, we have demonstrated that the ferric uptake regulator Fur plays an important role in Campylobacter acid survival. C. jejuni with a fur deletion was more sensitive to acid than the wild-type. Profiling the acid stimulon of the C. jejuni ∆fur mutant allowed us to uncover Fur-regulated genes under acidic conditions. The up-regulation of heat shock genes and the down-regulation of genes involved in flagellar and cell e

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Jones, Nicola L. "Microbial induction of programmed cell death in the gastrointestinal tract." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0017/NQ45750.pdf.

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47

Holland, Gail Skene. "Diversity of propionate producing bacteria from the pig gastrointestinal tract." Thesis, University of Aberdeen, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493590.

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Early weaning and a reduction in the use of antimicrobial growth promoters tend to increase the risk of enteric disease during a period when young pigs are particularly vulnerable, not least due to their immature gastrointestinal and immune systems. Additionally, young animals have yet to acquire a stable, mature commensal microflora. This study examined anaerobic bacterial groups and species present in the different sections of the porcine gastrointestinal tract (GIT), and attempted to identify components of the healthy microflora that might be used to reduce the risk of disease through proph

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48

Rose, Felicity. "The elucidation of antimicrobial activity in the human gastrointestinal tract." Thesis, University of Nottingham, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285756.

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Burke, M. P. D. "Bidirectional propulsion of devices along the gastrointestinal tract using electrostimulation." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1397662/.

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This thesis describes a method for propelling devices such as video capsule endoscopes in either direction along the small intestines using electrostimulation-induced muscular contractions. When swallowed, passive diagnostic ‘one-shot’ devices rely on sporadic peristaltic movement, possibly missing vital ‘areas of interest’. This bidirectional propulsion method provides active control for that all-important ‘second look’. Design considerations, within the dimensional constraints, required a device shape that would achieve maximum propulsion from safely induced useful contractions produced by t

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Ramsay, George. "Environmental signals that control T lymphocytes in the gastrointestinal tract." Thesis, University of Dundee, 2015. https://discovery.dundee.ac.uk/en/studentTheses/d287e221-26f9-43b2-b56b-927518a6349a.

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Abstract:

The Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) binds the Aryl Hydrocarbon Receptor (AHR) and also the Hypoxia Inducible Factor-1α (HIF-1α). Both the AHR and HIF-1α are key sensors of the microenvironment. Dietary tryptophan metabolites and microbiota catabolites are AHR ligands and HIF-1α is a sensor of low oxygen tension. Deletion of the AHR results in a loss of key lymphocyte subsets in the barrier organs of the skin and the intestine, but whether these effects are solely mediated by AHR–ARNT complexes is unclear. Moreover, the influence of HIF-1α-ARNT complexes in mucosal lymphoc

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