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Dissertations / Theses on the topic 'Diseases of the optic nerve'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

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1

Chan, Koon-ho, and 陳灌豪. "Clinical features, diagnosis and immunopathogenesis of neuromyelitis optica spectrum disorders." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48521681.

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Neuromyelitis optica (NMO) is a central nervous system inflammatory demyelinating disorders (CNS IDD) characterized by acute myelitis (AM) and optic neuritis (ON), especially clinically severe longitudinally extensive transverse myelitis (LETM) and simultaneous bilateral ON. Patients with recurrent AM especially LETM without ON, and patients with recurrent ON without AM may have disorders belonging to the spectrum of NMO, neuromyelitis optica spectrum disorders (NMOSD). NMO is likely autoimmune in nature as a significant proportion of patients are seropositive for aquaporin-4 (AQP4) autoantib

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2

Hazlewood, Ralph Jeremiah II. "Molecular genetics of optic nerve disease using patients with cavitary optic disc anomaly." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/1622.

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Glaucoma is the second leading cause of irreversible blindness in the United States and is the leading cause of blindness in African Americans. Cupping or excavation of the optic nerve, which sends the visual signal from the photoreceptors in the eye to the brain, is a chief feature of glaucoma. A similar excavated appearance of the optic nerve is also the primary clinical sign of other congenital malformations of the eye including optic nerve head coloboma, optic pit, and morning glory disc anomaly collectively termed cavitary optic disc anomaly (CODA). Clinical similarities between CODA and

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3

Chan, Ka-man, and 陳嘉雯. "Detection of anti-aquaporin (AQP4) autoantibodies in the diagnosis of neuromyelitis optica (NMO)." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44659192.

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4

Lo, Yuk-fai, and 盧育輝. "Comparison between tissue-based indirect immunofluorescence andenzyme-linked immunosorbent assays, two detection methods for anti-aquaporin-4 antibodies in neuromyelitis optica spectrum disorders." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46579266.

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5

Christopher, Mark Allen. "Computational methods to model disease and genetic effects on optic nerve head structure." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/1959.

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Glaucoma is a leading cause of blindness throughout the world and is estimated to affect 80 million by 2020. This disease causes progressive loss of vision and, left untreated, can lead to complete blindness. With treatment, however, disease progression can be slowed dramatically. This makes early detection and intervention crucial in preserving the vision of affected individuals. Onset and progression of glaucoma are associated with structural changes to an anatomical feature known as the optic nerve head (ONH). The ONH is the site of attachment between the retina and the optic nerve that car

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6

Miranda, Paulo Maurício do Amôr Divino 1982. "Alterações mitocondriais e nucleares associadas à neuropatia óptica." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/316698.

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Orientador: Edi Lúcia Sartorato<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-25T22:58:29Z (GMT). No. of bitstreams: 1 Miranda_PauloMauriciodoAmorDivino_D.pdf: 3949549 bytes, checksum: 8cd1e0647087ac34cd2bc0ed5d096d0b (MD5) Previous issue date: 2014<br>Resumo: A Neuropatia Óptica Hereditária de Leber (LHON) e a Atrofia Óptica Autossômica Dominante (ADOA ou OPA1) são doenças caracterizadas pela perda da visão bilateral, devido a uma degeneração do nervo óptico. Ambas as doenças apresentam também acuidade visual reduzida,

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Грицай, Т. А., М. И. Дяченко, Владислав Вiкторович Любчак, Владислав Викторович Любчак та Vladyslav Viktorovych Liubchak. "Медико-социальная значимость атрофии зрительных нервов в Украине на примере Сумской области". Thesis, Сумский государственный университет, 2016. http://essuir.sumdu.edu.ua/handle/123456789/47720.

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Заболевания зрительного нерва (ЗН) занимают 3-5 ранговые места в структуре офтальмологической заболеваемости развитых стран мира, особенное место занимает атрофия зрительных нервов (АЗН). Анализ первичной инвалидности в 2013 г., проведенный Т.А. Алифановой показал, что в Украине АЗН составляет 7,9% от всех инвалидизирующих форм офтальмопатологии.

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Aleksandar, Miljković. "Karakteristike glave očnog živca i peripapilarnih retinalnih nervnih vlakana kod pacijenata sa glaukomom." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2015. https://www.cris.uns.ac.rs/record.jsf?recordId=91924&source=NDLTD&language=en.

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Cilj ovog istraživanja bio je da se utvrdi razlika u debljini sloja retinalnih nervnih vlakana (RNFL) i parametara glave očnog živca kod pacijenata sa preperimetrijskim glaukomom i pacijenata sa glaukomom otvorenog ugla (POAG) u odnosu na zdravu populaciju, kao i da se utvrdi razlika u debljini RNFL i parametara glave očnog živca kod pacijenata sa POAG u odnosu na stepen progresije bolesti. Materijal i metode: U ovu kliničku, analitičku i opservacionu, po tipu &bdquo;slučaj-kontrola“ studiju, bilo je uključeno 120 pacijenata. Na osnovu kliničkog nalaza formirane su četiri grupe. Prva gru

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Amorim, Simone Consuelo de. "Estudo da condução nervosa em pacientes com a síndrome SPOAN." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-05112013-154543/.

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Introdução: A síndrome SPOAN é uma doença neurodegenerativa, de transmissão genética autossômica recessiva, até o momento reconhecida apenas no Brasil, que caracteriza-se por: paraplegia espástica, de início nos primeiros anos de vida e caráter progressivo; atrofia óptica congênita; neuropatia periférica sensitivo-motora axonal, de início a partir da primeira década de vida; sobressaltos à estimulação sonora, disartria, deformidades de coluna e pés e sinais extra piramidais. A sua caracterização foi feita por nosso grupo, que avaliou clinicamente 71 indivíduos, originários do Rio Grande do Nor

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10

Nevalainen, J. (Jukka). "Utilisation of the structure of the retinal nerve fiber layer and test strategy in visual field examination." Doctoral thesis, University of Oulu, 2010. http://urn.fi/urn:isbn:9789514262012.

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Abstract The aim of this study was to create a mathematical model of the retinal nerve fiber layer and of the entire hill of vision, and to compare different perimetric methods and test grids in the detection of visual field loss in glaucoma and optic neuritis. A mathematical model of the retinal nerve fiber layer was developed, based on traced nerve fiber bundle trajectories extracted from 55 fundus photographs of 55 human subjects. The model resembled the typical retinal nerve fiber layer course within 20° eccentricity from the foveola. The standard deviation of the calculated corresponding

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VAZQUEZ, JORGE ARTURO. "NERVE FIBER DIAMETER MEASUREMENTS USING HEMATOXYLIN AND EOSIN STAINING AND BRIGHTFIELD MICROSCOPY TO ASSESS THE NOVEL METHOD OF CHARACTERIZING PERIPHERAL NERVE FIBER DISTRIBUTIONS BY GROUP DELAY." DigitalCommons@CalPoly, 2014. https://digitalcommons.calpoly.edu/theses/1293.

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Peripheral neuropathies are a set of common diseases that affect the peripheral nervous system, causing damage to vital connections between various parts of the body and the brain and spinal cord. Different clinical conditions are known to selectively impact various size nerve fibers, which often makes it difficult to diagnose which peripheral neuropathy a patient might have. The nerve conduction velocity diagnostic test provides clinically useful information in the diagnosis of some peripheral neuropathies. This method is advantageous because it tends to be minimally invasive yet it provides

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12

MacLaren, Robert E. "Optic nerve regeneration." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318923.

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13

Amaral, Fernandes Marcela Scabello 1969. "Análise comparativa clínica e molecular da neuropatia óptica hereditária de Leber (LHON)." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308881.

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Orientador: Edi Lucia Sartorato<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-23T07:24:23Z (GMT). No. of bitstreams: 1 AmaralFernandes_MarcelaScabello_D.pdf: 2548021 bytes, checksum: 4a1e103fa460381f99df5a845fdfec67 (MD5) Previous issue date: 2013<br>Resumo: A neuropatia óptica hereditária de Leber (LHON) é uma doença mitocondrial, com herança materna, caracterizada pela perda (sub) aguda, indolor e bilateral da visão, escotoma central ou cecocentral e discromatopsia, devido à degeneração do nervo óptico por apop

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14

Taylor, Andrew. "Functional aspects of optic nerve regeneration." University of Western Australia. School of Animal Biology, 2006. http://theses.library.uwa.edu.au/adt-WU2006.0095.

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[Truncated abstract] Formation and consolidation of the retinotectal projection during optic nerve regeneration has been associated with two major interlinked processes. Initially, retinal ganglion cell (RGC) axons are guided by molecular guidance cues, such as the Eph receptor tyrosine kinases and their ligands, the ephrins, to their approximately correct location and form a coarse topographic map in the optic tecum. Such axon guidance occurs in the absence of neural activity and is considered to be activity-independent. The second process involves glutamatergic excitation, whereby correctly

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Hu, Ying. "Optic nerve regeneration in adult rat." University of Western Australia. School of Anatomy and Human Biology, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0080.

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[Truncated abstract] There is limited intrinsic potential for repair in the adult human central nervous system (CNS). Dysfunction resulting from CNS injury is persistent and requires prolonged medical treatment and rehabilitation. The retina and optic nerve are CNSderived, and adult retinal ganglion cells (RGCs) and their axons are often used as a model in which to study the mechanisms associated with injury, neuroprotection and regeneration. In this study I investigated the effects of a variety of strategies on promoting RGC survival and axonal regeneration after optic nerve injury, including

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Hu, Ying. "Optic nerve regeneration in adult rat /." Connect to this title, 2006. http://theses.library.uwa.edu.au/adt-WU2007.0080.

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17

Dangata, Yohanna Yanshiyi. "Morphometric analysis of the mammalian optic nerve." Thesis, University of Edinburgh, 1997. http://hdl.handle.net/1842/21185.

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Studies were carried out on the optic nerve of a variety of inbred strains and their F<SUB>1</SUB> hybrids. The postnatal development of a variety of different age groups was also analysed to provide baseline data as part of a study to determine the teratogenic effect of prenatal exposure to alcohol on the postnatal development of the optic nerve in this species. Furthermore, the optic nerve from adult <I>Small</I> <I>eye</I> (<I>Sey</I>) mice was analysed to determine the effects of the <I>Sey</I> gene mutation on the optic nerve of the mouse. Parameters analysed were mean cross-sectional are

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18

Ohlsson, Marcus. "On optic nerve injury : experimental studies on axonal regeneration in the adult mammalian CNS /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-656-1.

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19

Tatham, Andrew John. "The clinical relevance of structural changes of the optic nerve head and retinal nerve fibre layer in glaucomatous optic neuropathy." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10046134/.

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BACKGROUND: Imaging is widely used to quantify glaucomatous structural changes. Although previous studies have examined the relationship between structure and function, measured using standard automated perimetry (SAP), the true relevance of structural changes remains poorly understood. AIM: The aim of this body of work was to explore the structure-function relationship and to ascertain the point at which structural changes become associated with impaired ability to perform vision-dependent tasks. PLAN OF RESEARCH: After critically appraising previously described structurefunction models, an i

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20

Lam, Wai-yuan Leon. "Neuroprotection of low energy laser on retinal ganglion cells survival after optic nerve injury /." Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B2207904X.

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21

McDowell, Angela. "Analysis of Zebrafish Optic Tectum Visual Processing Before and After Optic Nerve Crush." TopSCHOLAR®, 2002. http://digitalcommons.wku.edu/theses/624.

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The visual system processes information at various levels. Initial processing takes place in the retina, which then sends information to the optic tectum, the first visual brain center in lower vertebrates, for further processing. There were two main goals of this study. The first goal was to obtain tectal evoked responses (TER) from adult zebrafish and to compare them to previous electroretinogram (ERG) spectral sensitivity data (Bilotta & Harrison, 1999). The second purpose of this study was to examine neural regeneration in the adult zebrafish at various times post-crush and to compare visu

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22

Mohan, Prithvi Mrinalini, and Prithvi Mrinalini Mohan. "Optic Nerve Hypoplasia Plus: A New Way of Looking at Septo-Optic Dysplasia." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/625105.

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Septo-optic dysplasia (SOD) is a rare congenital disorder that affects 1/10,000 live births. At its core, SOD is a disorder resulting from improper embryological development of mid-line brain structures. To date, there is no comprehensive understanding of the etiology of SOD. Currently, SOD is diagnosed based on the presence of at least two of the following three factors: (i) optic nerve hypoplasia (ii) improper pituitary gland development and endocrine dysfunction and (iii) mid-line brain defects, including agenesis of the septum pellucidum and/or corpus callosum. A literature review of

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23

Jones, Hannah. "Connective tissue in the human optic nerve head." Thesis, Cardiff University, 2014. http://orca.cf.ac.uk/59281/.

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Purpose: This thesis aimed to characterise and analyse the 3D micro- and nanoarchitecture of connective tissue within the lamina cribrosa (LC). Methods: The microarchitecture of load-bearing connective tissue components, elastin and fibrillar collagen, of the young, elderly and glaucomatous optic nerve head (ONH) was analysed following two-photon excited fluorescence, second harmonic generation and small angle light scattering. Microfocus and conventional small angle X-ray scattering were used to analyse ONH nanoarchitecture and the potential of X-ray microtomography (XMT) as a 3D imaging tech

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Giftochristos, Nick. "Studies of axonal regeneration in the mammalian optic nerve." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61729.

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O'Leary, Neil. "Optic nerve head image analysis for glaucoma progression detection." Thesis, City University London, 2011. http://openaccess.city.ac.uk/1154/.

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Glaucoma is a leading cause of visual disability across the world and when diagnosed the glaucoma patient will spend the rest of their life receiving treatment in managed clinical care. In the glaucoma clinic, retinal and optic nerve head (ONH) imaging can be used to help the clinician to manage patient treatment appropriately. By providing high resolution images of the optic nerve head structures and identifying changes therein related to disease onset and progression, an objective measure can be obtained as to how well or badly treatment is preventing further disease damage. This thesis cont

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Patten, Debra. "An electrophysiological study of the interaction between fenamate NSAIDs and the GABA(_A) receptor." Thesis, Durham University, 1999. http://etheses.dur.ac.uk/4561/.

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The effects of certain NSAIDs were determined on agonist-evoked responses recorded from rat neurones maintained in vitro using electrophysiological techniques. Initially, the rat isolated vagus and optic nerves were employed. Alphaxalone, pentobarbitone, propofol and the NSAID, mefenamic acid (MFA), potentiated GABA-evoked responses of the vagus nerve. Propofol (1-100µM) selectively potentiated GABA and glycine-evoked responses of the rat vagus and optic nerves, but had little effect on nicotinic acetylcholine-, a,β-methylene-ATP or 5-hydroxytryptamine-mediated responses. The interaction betwe

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Pile, Jenel. "Spectral Sensitivity of the Goldfish ERG and Optic Tectum Before and After Optic Nerve Damage." TopSCHOLAR®, 2001. http://digitalcommons.wku.edu/theses/693.

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It is well known that visual neurons in lower vertebrates regenerate after damage. Thus, the visual system has served as a useful model for neural regeneration studies. However, most of the research on neural regeneration has focused on the recovery of anatomical connections; little has been done assessing the return of visual function. The purpose of this study was to determine the return of function of the goldfish optic nerve at four time intervals after damage (crush). An increment threshold procedure was used to obtain electroretinogram (ERG) and tectal responses to light onset and termin

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Häntzschel, Janek, Naim Terai, Olga Furashova, Karin Pillunat, and Lutz E. Pillunat. "Comparison of Normal- and High-Tension Glaucoma: Nerve Fiber Layer and Optic Nerve Head Damage." Karger, 2014. https://tud.qucosa.de/id/qucosa%3A70550.

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Purpose: The aim of this study was to investigate differences in the nerve fiber layer and glaucoma-induced structural optic nerve head (ONH) damage in patients with normal- (NTG) and high-tension (HTG) glaucoma. Methods: In this retrospective pair-matched comparative study, 22 NTG and 22 HTG eyes were matched according to the same glaucomatous damage based on rim volume, rim area and disk size, as measured by Heidelberg retinal tomography (HRT III). Visual fields (VF) were assessed by Humphrey perimetry, and nerve fiber layer thickness was determined both by scanning laser polarimetry (GDxVCC

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Rivera, Andrea D. "Wnt and lithium promote gliogenesis in the adult optic nerve." Thesis, University of Portsmouth, 2014. https://researchportal.port.ac.uk/portal/en/theses/wnt-and-lithium-promote-gliogenesis-in-the-adult-optic-nerve(500741da-693a-4e20-9625-f7a4c031e05a).html.

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The central nervous system (CNS) is made up mainly of neurones, the signalling cells, and glia. The main types of glia are astrocytes and oligodendrocytes. Astrocytes are multifunctional cells with vital homeostatic roles, whereas oligodendrocytes are highly specialised to form axonal myelin sheaths, which are essential for rapid neuronal communication. Although glia are involved in every neurodegenerative disease, they have been less well studied as drug targets than neurones. Lithium has been used for decades as a mood stabilising agent and may have major therapeutic potential as a treatment

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Tan, James Chee-Hian. "Identification of glaucomatous optic nerve progression by scanning laser tomography." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406916.

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Pappenhagen, Nathaniel E. "METABOLIC CHANGES IN OPTIC NERVE HEAD ASTROCYTES FOLLOWING GLAUCOMIC DEFORMATION." Kent State University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=kent161909734917481.

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Bhattarai, Sunil Bhattarai. "Functional role of N-cadherin in zebrafish optic nerve regeneration." University of Akron / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=akron1470057018.

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Saul, Katherine E. "Differential gene expression in Danio rerio during optic nerve regeneration /." View online, 2008. http://ecommons.txstate.edu/bioltad/13.

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Heinecke, Karie A. "Myelin abnormalities in the optic and sciatic nerves of mice with GM1-gangliosidosis." Thesis, Boston College, 2014. http://hdl.handle.net/2345/bc-ir:103611.

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Thesis advisor: Thomas N. Seyfried<br>GM1 gangliosidosis is a glycosphingolipid lysosomal storage disease caused by a genetic deficiency of acid b-galactosidase (β-gal), the enzyme that catabolyzes GM1 within lysosomes. Accumulation of GM1 and its asialo form (GA1) occurs primarily in the brain, leading to progressive neurodegeneration and brain dysfunction. Less information is available on the neurochemical pathology in optic nerve and sciatic nerve of GM1- gangliosidosis. Here we analyzed the lipid content and myelin structure in optic and sciatic nerve in 7 and 10 month old normal β-gal (+/

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Schnichels, Sven [Verfasser]. "Occurrence and importance of the repulsive guidance molecule (RGM) in the optic nerve and retina of glaucoma and optic nerve crush animal models / Sven Schnichels." München : Verlag Dr. Hut, 2010. http://d-nb.info/1009484842/34.

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Alencar, Luciana Pereira Malta de. "Valor preditivo da topografia de disco óptico para o desenvolvimento de glaucoma." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5149/tde-07102011-114405/.

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Objetivos: Analisar o potencial da oftalmoscopia confocal de varredura a laser, através do Heidelberg Retina Tomograph (HRT), para predizer o risco de progressão em pacientes com suspeita de glaucoma. Comparar os resultados obtidos com o índice de probabilidade de glaucoma (GPS) do HRT aos resultados da análise de regressão de Moorfields (ARM), dos parâmetros morfométricos e da avaliação das fotografias estereoscópicas. Métodos: Uma coorte foi selecionada com 223 pacientes com suspeita de glaucoma, que foram seguidos por um período médio de 64,9 ± 37,3 meses. A suspeita de glaucoma baseou-se n

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Tamimi, Ehab A., Jeffrey D. Pyne, Dominic K. Muli, et al. "Racioethnic Differences in Human Posterior Scleral and Optic Nerve Stump Deformation." ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2017. http://hdl.handle.net/10150/626003.

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PURPOSE. The purpose of this study was to quantify the biomechanical response of human posterior ocular tissues from donors of various racioethnic groups to better understand how differences in these properties may play a role in the racioethnic health disparities known to exist in glaucoma. METHODS. Sequential digital image correlation (S-DIC) was used to measure the pressure-induced surface deformations of 23 normal human posterior poles from three racioethnic groups: African descent (AD), European descent (ED), and Hispanic ethnicity (HIS). Regional in-plane principal strains were compared

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Brasko, Csilla. "Expression of inward rectifier potassium channel subunits in optic nerve glia." Thesis, University of Portsmouth, 2013. https://researchportal.port.ac.uk/portal/en/theses/expression-of-inward-rectifier-potassium-channel-subunits-in-optic-nerve-glia(941b2bcc-471e-4ad4-affd-22547ba7533f).html.

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In glia inward rectifying potassium channels (Kir) are predominantly responsible for the high selective membrane permeability to K+, for the maintenance of the RMP close to the EK and for the clearance of excess K+ released during action potentials by the process of K+ buffering. In this study I have investigated the expression, subcellular localisation and heteromer forming ability of Kir4.1, Kir5.1 and Kir2.1 subunits in optic nerve glia. Immunocytochemistry results demonstrated the expression of Kir4.1, Kir5.1 and Kir2.1 subunits in the optic nerve astrocytes and oligodendrocytes. I used im

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James, Gregory Adam. "P2 purinoceptor mediated calcium signalling in optic nerve gila [i.e. glia]." Thesis, King's College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409092.

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Strouthidis, N. G. "Three-dimensional optical coherence tomography imaging of the optic nerve head." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1344086/.

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Background: the primary site of injury in glaucoma is likely to be at the lamina cribrosa (LC), deep within the optic nerve head (ONH). Optical coherence tomography (OCT) in glaucoma has, to date, focused on the detection of nerve fibre loss. Spectral domain OCT (SDOCT) has improved speed and axial resolution, allowing acquisition of three-dimensional ONH volumes and may capture targets deep within the ONH. This thesis explores the capabilities and potential of deep SDOCT imaging in the monkey ONH. Plan of research: an investigation was conducted into the detection of key landmarks that would

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林瑋源 and Wai-yuan Leon Lam. "Neuroprotection of low energy laser on retinal ganglion cells survivalafter optic nerve injury." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31222869.

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Kerr, Alicia Marie. "Cell-specific roles for CASK in the pathology of Optic Nerve Hypoplasia." Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/101514.

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Optic Nerve Hypoplasia (ONH) is the leading cause of childhood blindness in developed nations and its prevalence has been rising. Yet, we know little about the genetic, molecular, or cellular mechanisms underlying ONH. A previous study described ONH in a cohort of patients with mutations in CASK, an X-linked gene with established roles in neural development and synaptic function. I have demonstrated that heterozygous deletion of CASK in mice (Cask+/-) recapitulates many of the phenotypes observed in patients with CASK mutations, including ONH. This includes reduced optic nerve size, reduced n

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曹健生 and Kin-sang Cho. "The effects of intravitreal optic nerve and/or sciatic nerve grafts onthe survival, sprouting and regeneration of axotomised retinalganglion cells in hamsters." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1997. http://hub.hku.hk/bib/B31236753.

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Cho, Kin-sang. "The effects of intravitreal optic nerve and/or sciatic nerve grafts on the survival, sprouting and regeneration of axotomised retinal ganglion cells in hamsters /." Hong Kong : University of Hong Kong, 1997. http://sunzi.lib.hku.hk/hkuto/record.jsp?B18890404.

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Yang, Xiaoyun. "Automated identification of optic nerve head and blood vessels in retinal images." Thesis, Ulster University, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444521.

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Jafari, Seyed Saeed Seyed. "Responses in the guinea pig optic nerve four hours after stretch-injury." Thesis, University of Glasgow, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298977.

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Wang, Silas Lancelot. "Clinical characteristics and treatment response to radiotherapy of optic nerve sheath meningiomas." [New Haven, Conn. : s.n.], 2007. http://ymtdl.med.yale.edu/theses/available/etd-08282007-150948/.

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Vaughan, Parker Andrew. "Electrophysiology of Optic Nerves in Methylglyoxal Treated Mice." Wright State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=wright1590769538838536.

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Niloff, Matthew. "The regulation of gefiltin mRNA expression by the tectum during optic nerve regeneration in the goldfish." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0003/MQ44233.pdf.

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Chiu, Yee-hang Thomas. "Intraocular pressure, optic nerve fiber layer thickness and visual field in normotensive eyes with narrow drainage angle /." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B37207994.

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