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Relevant bibliographies by topics / Dissolution study of methyldopa and Hydrochlorothiazide

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Academic literature on the topic 'Dissolution study of methyldopa and Hydrochlorothiazide'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Dissolution study of methyldopa and Hydrochlorothiazide"

1

H.N, Khan* Kodli Puja Sana Javeria MD Zameeruddin A. G. Mangulkar V.B Bharkad. "STABITY INDICATING DISSOLUTION METHOD DEVELOPMENT FOR ESTIMATION OF METHYLDOPA AND HYDROCHLOROTHIAZIDE IN COMBINE DOSAGE FORM." Indo American Journal of Pharmaceutical Sciences 04, no. 09 (2017): 3024–32. https://doi.org/10.5281/zenodo.910187.

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The aim of this work was to develop validate a dissolution test for Methyldopa and Hydrochlorothiazide in combination tablets using spectrophotometric method. The dissolution established conditions were 900 mL of 0.1M HCl pH 1.0 as dissolution medium, using a paddle apparatus at a stirring rate of 50 rpm. The drug release was evaluated by UV spectrophotometric method the areas of solution were recorded at 274-284 nm and266-276 nm for Methyldopa and Hydrochlorothiazide respectively. It can be concluded that the method developed consists in an efficient alternative for assay of dissolution for t

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2

H.N, Khan* Kodli Puja Sana Javeria MD Zameeruddin A. G. Mangulkar V.B Bharkad. "STABITY INDICATING DISSOLUTION METHOD DEVELOPMENT FOR ESTIMATION OF METHYLDOPA AND HYDROCHLOROTHIAZIDE IN COMBINE DOSAGE FORM." Indo American Journal of Pharmaceutical Sciences 04, no. 09 (2017): 3024–32. https://doi.org/10.5281/zenodo.897504.

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The aim of this work was to develop validate a dissolution test for mthyldopa and Hydrochlorothiazide in combination tablets using spectrophotometric method. The dissolution established conditions were 900 mL of 0.1M HCl pH 1.0 as dissolution medium, using a paddle apparatus at a stirring rate of 50 rpm. The drug release was evaluated by UV spectrophotometric method the area of solution were recorded at 274-284 nm and266-276 nm for MD and HCTZ respectively . it can be concluded that the method developed consists in an efficient alternative for assay of dissolution for tablets. The method was v

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3

Fernandez, P. G., W. Snedden, J. W. Snellen, A. B. Galway, and C. Nath. "Increased metabolic heat production following chronic alpha-methyldopa therapy in hypertensives." Canadian Journal of Physiology and Pharmacology 64, no. 2 (1986): 138–44. http://dx.doi.org/10.1139/y86-021.

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The objective of this study was to measure metabolic heat production in mild-moderate hypertensives when given chronic alpha-methyldopa for control of hypertension and to compare this with hydrochlorothiazide. Four men and one woman, age range 29–55 years, euthyroid, and not previously on alpha-methyldopa, had their drugs replaced by placebo for 4 weeks, and then alpha-methyldopa or hydrochlorothiazide was randomized single blindedly to patients. The dose of each drug was increased until the ambulatory diastolic blood pressure was less than 95 mmHg (1 mmHg = 133.322 Pa), and then the dose was

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4

Ammanage, Anand Shripal, Yojana Dadasaheb Patil, Jagadish Kamalanath Saboji, Amolkumar Ashok Kempwade, and Ravindra Durdundayya Hiremath. "EXPLORING THE POTENTIAL OF ORODISPERSIBLE TABLET OF ENALAPRIL MALEATE AND HYDROCHLOROTHIAZIDE DRUG COMBINATION." INDIAN DRUGS 57, no. 03 (2020): 47–54. http://dx.doi.org/10.53879/id.57.03.11333.

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The objective of the present work was to formulate and evaluate orodispersible tablets of enalapril maleate and hydrochlorothiazide combination to overcome the shortcomings of conventional dosage forms and improve patient compliance. Eleven formulations were prepared by wet granulation method using sodium starch glycolate as superdisintegrant and microcrystalline cellulose and Pearlitol 200 SD as diluents. The process variables were optimized to get desired characteristics. Various pre-compression and post-compression quality control parameters were evaluated. The wetting and disintegration ti

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5

Talele, Swati, Priyanka Kajale, Shital Bhil, Amit Gaikwad, and Laxmikant Borse. "Formulation of Drug-polyelectrolyte Complex for Enhancement of Solubility of Hydrochlorthiazide." Biosciences Biotechnology Research Asia 20, no. 4 (2023): 1291–302. http://dx.doi.org/10.13005/bbra/3176.

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ABSTRACT: The objective of this work is to formulate Nanoplex formulation which enhances the drug solubility and also to enhance the dissolution rate of the formulation which were prepared. Complex nanoplex is formed when positively or negatively charged molecules of the drug react with oppositely charged polyelectrolyte. In this study, we use hydrochlorothiazide as a study drug and dextran sulphate as anionic polyelectrolyte. During the procedure crystalline nanoplex is formed due to electrostatic interactions between API and polyelecrolyte. The nanoplex shaped by this method upgrades dissolv

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6

Al-Kubati, Sana Saleh, and Fairoz Adel Hammed. "Pharmaceutical Study to Assess the Equivalence of the Commercial Brands of Losartan Potassium Tablets Available in Aden Governorate, Yemen." University of Aden Journal of Natural and Applied Sciences 28, no. 2 (2025): 75–85. https://doi.org/10.47372/uajnas.2024.n2.a07.

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Losartan potassium, a non-peptide angiotensin II receptor antagonist, is prescribed by the physicians for hypertension treatment. In Aden governorate, Yemen, losartan is available as oral tablets and tablets combining losartan potassium and hydrochlorothiazide. A study comparing generic brands of 50 mg Losartan potassium tablets to their reference brand was conducted to determine their pharmaceutical equivalency. The study involved quality control parameters and in vitro dissolution studies using the USP method. The results showed that the seven brands of losartan potassium tablets met the spe

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7

Povetkin, S. V., V. I. Gikavyj, N. G. Bachinski, et al. "Comparative Pharmacoepidemiological Assessment of Antihypertensive Drugs Administration Structure in Pregnant Women in Routine Medical Practice in Kursk and Chisinau." Rational Pharmacotherapy in Cardiology 18, no. 5 (2022): 571–77. http://dx.doi.org/10.20996/1819-6446-2022-10-02.

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Aim. To study the structure of antihypertensive drugs prescription in pregnant women in routine practice in Kursk and Chisinau.Material and methods. The study design was observational descriptive cross-sectional. Authors conducted a survey of doctors in medical organizations in Kursk and Chisinau in 2017-2018.Results. Respondents from Kursk and Chisinau preferred methyldopa in prescriptions of central alpha-adrenergic receptor agonists. Doctors from Chisinau used clonidine in 14.3% of cases. The leading place in the group of calcium channel blockers belonged to short-acting nifedipine. Among b

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8

Leon, Rosmery Merma, Michele Georges Issa, Marcelo Dutra Duque, Josiane Souza Pereira Daniel, and Humberto Gomes Ferraz. "Development of a Discriminative Dissolution Method, Using In-Silico Tool for Hydrochlorothiazide and Valsartan Tablets." Pharmaceutics 15, no. 6 (2023): 1735. http://dx.doi.org/10.3390/pharmaceutics15061735.

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Hydrochlorothiazide (HTZ) and Valsartan (VAL) are poorly soluble drugs in BCS classes IV and II. This study aimed to develop a method to assess the dissolution profile of tablets containing HTZ (12.5 mg) and VAL (160 mg) as a fixed-dose combination, using in silico tools to evaluate products marketed in Brazil and Peru. Firstly, in vitro dissolution tests were performed using a fractional factorial design 33−1. Then, DDDPlus™ was used to carry out experimental design assays of a complete factorial design 33. Data from the first stage were used to obtain calibration constants for in silico simu

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9

Kathpalia, H., and K. Jogi. "DESIGN AND OPTIMIZATION OF IMMEDIATE RELEASE TABLETS OF HYDROCHLOROTHIAZIDE USING THE DESIGN OF EXPERIMENTS APPROACH." INDIAN DRUGS 53, no. 09 (2016): 27–33. http://dx.doi.org/10.53879/id.53.09.10562.

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The aim of the present study was to develop and optimize immediate release tablets using hydrochlorothiazide (HCTZ) as a model drug candidate applying Design of Experiments (DoE) approach. Immediate release tablets were prepared using corn starch as a disintegrant and Polysorbate 80 as a solubilizer. Risk assessment was carried out with subsequent application of 22 factorial design in duplicate for evaluating the interactions and effects of the design factors on critical quality attributes. The design space was obtained by applying DOE and multivariate analysis, so as to ensure desired disinte

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10

Fadhilla, Salma Nara, and Dharma Permana. "The use of antihypertensive drugs in the treatment of essential hypertension at outpatient installations, Puskesmas Karang Rejo, Tarakan." Yarsi Journal of Pharmacology 1, no. 1 (2020): 7–14. http://dx.doi.org/10.33476/yjp.v1i1.1209.

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Background: Essential hypertension is the most common type of hypertension, affecting 95% of hypertensive patients. Essential hypertension can be managed through a combination lifestyle changes and antihypertensive drugs. The aim of this study was to know the use of antihypertensive drugs in the treatment of essential hypertensive at outpatient installations, Puskesmas Karang Rejo, Tarakan.Methods: The research method is descriptive by using secondary data from complete patient medical records of the essential hypertension patients undergoing outpatient treatment at Puskesmas Karang Rejo, Tara

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