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Relevant bibliographies by topics / DNA cross-linking / Dissertations / Theses

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Dissertations / Theses on the topic 'DNA cross-linking'

Author: Grafiati

Published: 4 June 2021

Last updated: 11 February 2022

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1

Drew, Gail L. "DNA-Protein Cross-Linking by Pyrrolizidine Alkaloids." DigitalCommons@USU, 1997. https://digitalcommons.usu.edu/etd/3919.

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Pyrrolizidine alkaloids (PAs) are natural plant compounds found in hundreds of plant species worldwide and are reported to have cytotoxic, carcinogenic, antimitotic, and gentotoxic activity. PAs are metabolized by the cytochrome P450 (CYP) sytem to the pyrrole or the N-oxide form. They pyrroles are bifunctional electrophillic alkylators that bind cellular nucleophiles such as DNA and proteins and disrupt normal cell processes, including DNA replication and gene transcription, and can cause megalocytosis. The pyrroles dehyrosenecionine (DHSN) and dehydromoncrotaline (DHMO) are among the most po

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2

Flett, Fiona Jane. "Mapping protein-DNA interactions using UV cross-linking and mass spectrometry." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/17996.

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Protein-nucleic acid interactions play essential roles in all living cells in various cellular functions. The study of these interactions can reveal important structural and functional information. UV cross-linking of nucleic acids to proteins in combination with mass spectrometry is a powerful technique to identify proteins, peptides and the amino acids involved in intermolecular interactions within nucleic acid-protein complexes. However, the mass spectrometric identification of cross-linked nucleic acid-protein heteroconjugates in complex mixtures and MS/MS characterisation of the specific

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3

Luo, Dan. "Novel cross-linking technologies to assess protein-DNA binding and DNA-DNA complexes for gene delivery and expression /." The Ohio State University, 1997. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487946776022443.

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4

Caulfield, Jennifer L. (Jennifer Leigh). "The chemistry of nitric oxide-induced deamination and cross-linking of DNA." Thesis, Massachusetts Institute of Technology, 1997. http://hdl.handle.net/1721.1/43594.

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5

Ghanekar, Ruchi. "Cross chip probe matching tool a tool for linking probes from microarrays within and across species /." Birmingham, Ala. : University of Alabama at Birmingham, 2006. https://www.mhsl.uab.edu/dt/2008r/ghanekar.pdf.

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6

Guo, Chuanxin. "Design of Sequence-Specific Binding Py-Im Polyamides and DNA Interstrand Cross-linking Agents." 京都大学 (Kyoto University), 2016. http://hdl.handle.net/2433/217133.

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7

Yoshikiyo, Kazunori. "KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents." Kyoto University, 2013. http://hdl.handle.net/2433/180458.

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Kazunori Yoshikiyo, Katja Kratz, Kouji Hirota, Kana Nishihara, Minoru Takata, Hitoshi Kurumizaka, Satoshi Horimoto, Shunichi Takeda, and Josef Jiricny "KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents" PNAS 2010 107 (50) 21553-21557; published ahead of print November 29, 2010, doi:10.1073/pnas.1011081107<br>Kyoto University (京都大学)<br>0048<br>新制・論文博士<br>博士(医学)<br>乙第12772号<br>論医博第2063号<br>新制||医||1000(附属図書館)<br>30755<br>(主査)教授小松賢志, 教授小川誠司, 教授松本智裕<br>学位規則第4条第2項該当

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8

Corcoran, Kathryn Elizabeth. "Synthetic approaches to c-ring unsaturated DNA cross-linking pyrrolo[2,1-c][1,4]benzodiazepine dimers." Thesis, University of Portsmouth, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368745.

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The pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) are a diverse group of antitumour antibiotics in which there has been growing interest over the past 30 years. These compounds bind covalently within the minor groove of DNA via the formation of an aminal bond between the N10-C11 imine functionality of the PBD and the exocyclic C2-NH2 of a guanine base, resulting in the inhibition of processes including DNA replication and transcription, thus leading to cell death. PBD `dimers' have the ability to form irreversible interstrand cross-links with DNA. One example, DSB-120, has been shown to recognise

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9

Lobo, Sylvia Grace Marianne Jean. "The design, synthesis and evaluation of a novel DNA cross-linking agent based on the pyrrolobenzodiazepines." Thesis, University of Portsmouth, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320301.

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10

Croker, Stephen John. "Synthetic studies towards a novel DNA targeted cross-linking agent based on DC-81 and CC-1065." Thesis, University of Portsmouth, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310416.

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11

Komarov, Dmitry Yurievich. "OXIDATION OF NUCLEIC ACIDS: CHEMISTRY OF PURINE QUINONES AND DEVELOPMENT OF NOVEL PHOTOOXIDIZING AGENTS." Bowling Green State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1285956212.

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12

Wilson, Stuart Craig. "Design, synthesis and biological evaluation of a DNA cross-linking antitumour agent based on the pyrrolo[2,1-c][1,4]benzodiazepine ring system." Thesis, University of Portsmouth, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320300.

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13

Phelps, Randall Alan. "Lack of an early S phase delay following DNA cross-linking precedes P53-mediated G2 arrest and apoptosis in fanconi anemia cells /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/5030.

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14

Guggenheim, Evan R. "Photo-cross-linking and identification of nuclear proteins that bind to DNA containing a site-specific adduct of cis-[Pt(NH₃)(N-6-aminohexyl)-4-benzophenonamide)CI₂]." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/46040.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2008.<br>In title on title page, "cis" appears as italic. Vita.<br>Includes bibliographical references.<br>cis-Diamminedichloroplatinum(II), or cisplatin, is the most successful cancer drug ever discovered. It has been used for over 30 years in the treatment of several types of malignancies, with the highest success rates in testicular cancer patients. Despite the triumphs of this drug, the exact mechanisms of cell-killing by cisplatin are not fully understood. A more complete understanding of the ability of this drug

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15

Marten, Lara Maleen [Verfasser], and Kerstin [Akademischer Betreuer] Borgmann. "Impact of mutated p53 on homologous recombination and the FA/BRCA pathway in NSCLC H1299 cells in response to DNA cross-linking drugs / Lara Maleen Marten. Betreuer: Kerstin Borgmann." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2016. http://d-nb.info/1095766406/34.

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16

Marten, Lara Maleen Verfasser], and Kerstin [Akademischer Betreuer] [Borgmann. "Impact of mutated p53 on homologous recombination and the FA/BRCA pathway in NSCLC H1299 cells in response to DNA cross-linking drugs / Lara Maleen Marten. Betreuer: Kerstin Borgmann." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2016. http://nbn-resolving.de/urn:nbn:de:gbv:18-77538.

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17

Véliz, Montes Cinthya Yamila [Verfasser], Jens [Akademischer Betreuer] Kurreck, Tomás [Akademischer Betreuer] Torres, et al. "Phthalocyanine-fullerene dyads and DNA interstrand cross-linking on surface / Cinthya Yamila Véliz Montes ; Gutachter: Rudolf J. Schneider, Felix Zamora Abanades, João Paulo Costa Tomé, Maria Salomé Rodríguez Morgade ; Jens Kurreck, Tomás Torres." Berlin : Technische Universität Berlin, 2018. http://d-nb.info/1171306326/34.

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18

Xu, Guozhou. "Crystal structures of the Fanconi anemia proteins : structure of the interstrand cross-linking repair protein Fanconi anemia protein I (FANCI); structure of the human FANCF C-terminal domain; reconstitution and crystallilzation of the sub-complexes in the Fanconi anemia core complex /." Access full-text from WCMC, 2009. http://proquest.umi.com/pqdweb?did=1692100351&sid=1&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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19

Wheate, Nial Joseph Chemistry Australian Defence Force Academy UNSW. "Platinum anti-cancer complexes." Awarded by:University of New South Wales - Australian Defence Force Academy. School of Chemistry, 2001. http://handle.unsw.edu.au/1959.4/38704.

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[Formulae and special characters can only be approximated here. Please see the pdf version of the Abstract for an accurate reproduction.] Several inert platinum complexes were synthesised: [(en)Pt([special character]-dpzm)2Pt(en)]4+, [{Pt(dien)}2[special character]-dpzm]4+, [{Pt(dien)}2[special character]-H2N-(CH2)6-NH2]4+, cis-[(NH3)2Pt([special character]--dpzm)2Pt(NH3)2]4+, trans-[Pt(NH3)2([special character]-dpzm)2]2+. Three active complexes, all with chloro ligands, were also synthesised: trans-[{Pt(NH3)Cl2}2[special character]-dpzm)], trans-[{Pt(NH3)2Cl}2[special character]-dpzm]2+ (di-

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20

Tammaccaro, Salvina. "Roles of HNF1B as a book marking factor." Thesis, Université de Paris (2019-....), 2019. https://theses.md.univ-paris-diderot.fr/TAMMACCARO_Salvina_va2.pdf.

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HNF1B est un facteur de transcription préférentiellement exprimé de l’épithélium dans les reins et muté fréquemment chez les patients qui souffrent d’anomalies congénitales du rein et des voies urinaires. HNF1B est un facteur marque-page car il reste étroitement lié à la chromatine mitotique et joue un rôle essentiel dans la reprogrammation de l’expression génétique après la condensation chromosomique qui se produit lors de la mitose. Afin de comprendre la fonction possible jouée par HNF1B, j’ai caractérisé ses partenaires protéiques. Un crible double hybride a permis de montrer que HNF1B inte

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21

Nguyen, Huynh Nha Thi. "Développements en spectrométrie de masse pour l’étude des complexes biologiques." Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAF045/document.

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L’élucidation des interactions non-covalentes des complexes biologiques revêt d’une importance majeure dans la compréhension du fonctionnement cellulaire. L’objectif de ce travail de thèse est d’approfondir les développements de la spectrométrie de masse (MS) pour l’étude de ces complexes, que ce soit par MALDI-MS (la désorption-ionisation laser assistée par matrice) ou par ESI-MS (l’ionisation électrospray). Ce travail s’est articulé autour de trois axes : i) étude de la stœchiométrie et de la topologie du complexe SAGA HAT (Spt-Ada-Gcn5 Acétyltransferase, module Histone Acétyl Transferase) p

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22

Michaelson-Richie, Erin Denise. "DNA-protein cross-linking by bifunctional DNA alkylating agents /." Diss., 2010. http://purl.umn.edu/60701.

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23

Wilkinson, Gary P., James P. Taylor, Steven D. Shnyder, et al. "Preliminary pharmacokinetic and bioanalytical studies of SJG-136 (NSC 694501), a sequence-selective pyrrolobenzodiazepine dimer DNA-cross-linking agent." 2004. http://hdl.handle.net/10454/3609.

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No<br>SJG-136 is a synthetic pyrrolobenzodiazepine (PBD) dimer in which two DNA-alkylating subunits are linked through an inert propanedioxy tether. Biophysical and biochemical studies of SJG-136 have shown a remarkable affinity for DNA and potent cytotoxicity in vitro. On this basis, together with its unique sequence selectivity and interstrand DNA cross-linking activity, SJG-136 has been selected for clinical trials. This study examines the pharmacological characteristics of SJG-136 and provides the first report of pharmacokinetic properties for this agent. A sensitive, selective and reprodu

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24

洪士欽. "New Photo-Induced DNA Cross-linking and Cleaving Agents as well as Developments of New Benzimidazoles as Potential Anti-Hepatitis C Virus Drug." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/47547582547004994074.

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博士<br>國立清華大學<br>化學系<br>94<br>In this thesis, I developed a synthetic route for the preparation of phthalimide derivatives as novel photo-induced DNA cross-linking agents. I also explored the DNA cleaving ability of oxime esters, which can perform double-strand scission upon UV irradiation. Furthermore, a series of benzimidazoles were prepared and screened their inhibitions against HCV. In part 1 of this thesis, three new photo-induced DNA cross-linking agents were synthesized. Irradiation with UV light (312 nm) of these cross-linking agents in a phosphate buffer containing the linearize

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25

Slavata, Lukáš. "Studium interakce mezi DNA a transkripčními faktory pomocí hmotnostní spektrometrie." Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-332586.

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Transcription factors play crucial regulatory role within the cell and the entire multicellular organism. The important factor is its ability to interact with other regulatory proteins and DNA. Despite the fact that a large part of the interaction network is already documented, detailed information on the structure and dynamics of protein-protein and protein-DNA complexes is still scarce. In this thesis we focused on the possibility of studying conformational changes given by the transcription factor-DNA complex formation using the methods of structural mass spectrometry: hydrogen/deuterium ex

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