Relevant bibliographies by topics / Dole effect

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Dole effect'

Author: Grafiati
Published: 25 May 2024
Last updated: 31 July 2025

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Journal articles on the topic "Dole effect"

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Hoffmann, Georg, Matthias Cuntz, Christine Weber, et al. "A model of the Earth's Dole effect." Global Biogeochemical Cycles 18, no. 1 (2004): n/a. http://dx.doi.org/10.1029/2003gb002059.

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Žukovec Topalović, Dijana, Lada Živković, Andrea Čabarkapa, et al. "Dry Olive Leaf Extract Counteracts L-Thyroxine-Induced Genotoxicity in Human Peripheral Blood LeukocytesIn Vitro." Oxidative Medicine and Cellular Longevity 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/762192.

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The thyroid hormones change the rate of basal metabolism, modulating the consumption of oxygen and causing production of reactive oxygen species, which leads to the development of oxidative stress and DNA strand breaks. Olive (Olea europaeaL.) leaf contains many potentially bioactive compounds, making it one of the most potent natural antioxidants. The objective of this study was to evaluate the genotoxicity of L-thyroxine and to investigate antioxidative and antigenotoxic potential of the standardized oleuropein-rich dry olive leaf extract (DOLE) against hydrogen peroxide and L-thyroxine-indu
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Ouellette, Lisa Larrimore, and Bhaven N. Sampat. "Using Bayh-Dole Act March-In Rights to Lower US Drug Prices." JAMA Health Forum 5, no. 11 (2024): e243775. http://dx.doi.org/10.1001/jamahealthforum.2024.3775.

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ImportanceIn December 2023, the Biden-Harris Administration released a proposed framework for exercising government march-in rights (effectively granting compulsory licenses for those patents to generic drug makers) under the Bayh-Dole Act on patents on taxpayer-funded drugs, which has renewed questions about whether march-in rights could promote cost savings through generic competition or harm pharmaceutical innovation.ObjectivesTo determine the feasibility of using march-in rights to remove patent barriers to generic competition.Design, Setting, and ParticipantsThis cross-sectional study exa
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Goenka, Shilpi, and Sanford R. Simon. "A Novel Pro-Melanogenic Effect of Standardized Dry Olive Leaf Extract on Primary Human Melanocytes from Lightly Pigmented and Moderately Pigmented Skin." Pharmaceuticals 14, no. 3 (2021): 252. http://dx.doi.org/10.3390/ph14030252.

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Benolea® (EFLA®943) is a standardized dry olive leaf extract (DOLE) considered safe for food consumption and has demonstrated superior pharmaceutical benefits such as antioxidant, anti-obesity, and anti-hypertensive activities. However, there is no study on its effects on melanogenesis yet. Disruption in the sequence of steps in melanogenesis can lead to hypopigmentary disorders which occur due to reduced production or export of pigment melanin in the skin. There is a need for safe and nontoxic therapeutics for the treatment of hypopigmentation disorders. Herein, we studied the effects of DOLE
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Angert, A., J. Muhr, R. Negron Juarez, et al. "The contribution of respiration in tree-stems to the Dole Effect." Biogeosciences Discussions 9, no. 1 (2012): 1097–114. http://dx.doi.org/10.5194/bgd-9-1097-2012.

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Abstract. Understanding the variability and the current value of the Dole Effect, which has been used to infer past changes in biospheric productivity, requires accurate information on the discrimination associated with respiratory oxygen consumption in each of the biosphere components. Respiration in tree stems is an important component of the land carbon cycle. Here we measured, for the first time, the discrimination associated with tree stem oxygen uptake. The measurements included tropical forest trees, which are major contributors to the global fluxes of carbon and oxygen. We found discri
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Angert, A., J. Muhr, R. Negron Juarez, et al. "The contribution of respiration in tree stems to the Dole Effect." Biogeosciences 9, no. 10 (2012): 4037–44. http://dx.doi.org/10.5194/bg-9-4037-2012.

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Abstract. Understanding the variability and the current value of the Dole Effect, which has been used to infer past changes in biospheric productivity, requires accurate information on the isotopic discrimination associated with respiratory oxygen consumption in each of the biosphere components. Respiration in tree stems is an important component of the land carbon cycle. Here we measured, for the first time, the discrimination associated with tree stem oxygen uptake. The measurements included tropical forest trees, which are major contributors to the global fluxes of carbon and oxygen. We fou
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Malaizé, B., D. Paillard, J. Jouzel, and D. Raynaud. "The Dole effect over the last two glacial-interglacial cycles." Journal of Geophysical Research: Atmospheres 104, no. D12 (1999): 14199–208. http://dx.doi.org/10.1029/1999jd900116.

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Famiglietti, Michela, Alessandro Savastano, Rosa Gaglione, Angela Arciello, Daniele Naviglio, and Loredana Mariniello. "Edible Films Made of Dried Olive Leaf Extract and Chitosan: Characterization and Applications." Foods 11, no. 14 (2022): 2078. http://dx.doi.org/10.3390/foods11142078.

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Nowadays a possible strategy in food preservation consists of the use of active and functional packaging to improve safety and ensure a longer shelf life of food products. Many studies refer to chitosan-based films because of the already-known chitosan (CH) antibacterial and antifungal activity. In this work, we developed CH-based films containing Dried Olive Leaf Extract (DOLE) obtained by Naviglio extractor, with the aim to investigate the polyphenols yield and the antioxidant activity of this extract entrapped in CH-based-edible films. Olive tree cultivation produces a huge amount of byprod
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Huang, Enqing, Pinxian Wang, Yue Wang, et al. "Dole effect as a measurement of the low-latitude hydrological cycle over the past 800 ka." Science Advances 6, no. 41 (2020): eaba4823. http://dx.doi.org/10.1126/sciadv.aba4823.

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The quest of geological proxies to evaluate low-latitude hydrological changes at a planetary scale remains an ongoing issue. The Dole effect is such a potential proxy owing to its global character. We propose a new approach to recalculate the fluctuation of the Dole effect (∆DE*) over the past 800 thousand years (ka). The ∆DE* calculated this way is dominated by precession cycles alone, with lesser variance in the obliquity bands and almost no variance in the eccentricity bands. Moreover, the ∆DE* is notably correlated with Chinese stalagmite δ18O record over the past 640 ka; simulated terrest
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Nevile, J. W. "Employment Outcomes of Work for the Dole: An Analysis of the DEWRSB Net Impact Report." Economic and Labour Relations Review 14, no. 1 (2003): 127–42. http://dx.doi.org/10.1177/103530460301400110.

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Since the data necessary to make a formal quantitative analysis of Work for the Dole employment outcomes is not available to researchers who are independent of Commonwealth Government Departments, this article examines the (then) Department of Employment, Workplace Relations and Small Business (DEWRSB) net impact report, finding in it a number of weaknesses. The combined effect of these is to inflate the estimated value for net impact but a corrected estimate is still higher than many consider likely. Any figure for the net impact estimate of an Australian labour market program can only be a b
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Dissertations / Theses on the topic "Dole effect"

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Paul, Clémence. "Fractionnement du dioxygène lors des processus biologiques : application à la reconstruction de la productivité passée de la biosphère." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASJ002.

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La composition isotopique du dioxygène piégé dans les bulles d'air des carottes de glace peut être utilisée pour reconstituer la productivité globale de la biosphère dans le passé ainsi que pour documenter l'évolution du cycle de l'eau aux basses latitudes. Le travail de cette thèse a été d'améliorer l'interprétation du δ18O de l'O2. Pour cela, nous avons affiné la détermination des différents coefficients de fractionnement associés au cycle de l'oxygène au niveau de la biosphère terrestre, c'est-à-dire pendant les processus de respiration et de photosynthèse. Afin de quantifier ces coefficien
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Alfvén, Tobias. "Bone and kidney effects from cadmium exposure : dose effect and dose response relationships /." Stockholm : Karolinska Univ. Press, 2002. http://diss.kib.ki.se/2002/91-7349-341-4.

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Kafrouni, Marilyne. "Relation dose-effet et optimisation de la dosimétrie en radiothérapie interne sélective du carcinome hépatocellulaire." Thesis, Montpellier, 2019. http://www.theses.fr/2019MONTT007/document.

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La radiothérapie interne sélective (RTIS), en plein développement ces dernières années, constitue une alternative thérapeutique pour les cancers primaires et secondaires inopérables du foie. Le principe repose sur l’administration intra-artérielle de microsphères chargées d’yttrium-90 avec pour objectif la destruction des cellules tumorales par l’irradiation.L’activité d’yttrium-90 à administrer au patient est actuellement généralement prescrite à partir d’approches semi-empiriques ou peu personnalisées, faciles à mettre en place cliniquement. De nouveaux outils sont aujourd'hui disponibles se
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Rostand, Neil. "Modélisation compacte de l'effet des radiations naturelles des dispositifs sub-28nm pour des applications automobiles et aéronautiques." Thesis, Toulouse, ISAE, 2019. http://www.theses.fr/2019ESAE0035.

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L’objectif de cette thèse était le développement de modèles SET (Single Event Transient) et TID (Total Ionizing Dose) pour les MOSFETs de technologies fortement intégrées, reposant notamment sur la technologie SOI. Ces modèles devaient respecter les standards de la modélisation compacte afin d’assurer leur utilisation dans les simulateurs de circuits SPICE (ELDO, SPECTRE, PSPICE …) tout en assurant la justesse du contenu physique. Le langage d’implémentation est alors le Verilog-A. En 1A, l’investigation physique des SET a été effectuée à l’aide de simulations TCAD. Cette tâche a supporté le d
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Morency, Catherine-Ève. "Effets de l'estradiol et de la progestérone sur le contrôle respiratoire en situation hypoxique chez le raton nouveau-né et impacts à long terme." Thesis, Université Laval, 2006. http://www.theses.ulaval.ca/2006/23851/23851.pdf.

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Sutton, Akil K. "Displacement Damage and Ionization Effects in Advanced Silicon-Germanium Heterojunction Bipolar Transistors." Thesis, Georgia Institute of Technology, 2005. http://hdl.handle.net/1853/7217.

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A summary of total dose effects observe in advanced Silicon Germanium (SiGe) Heterojunction Bipolar Transistors (HBTs) is presented in this work. The principal driving froces behin the increased use of SiGe BiCMOS technology in space based electronics systems are outlined in the motivation Section of Chapter I. This is followed by a discussion of the strained layer Si/SiGe material structure and relevant fabrication techniques used in the development of the first generation of this technology. A comprehensive description of the device performance is presented. Chapter II presents an overview
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Rossouw, Maria Susanna. "Validation of endpoints as biomarkers of low-dose radiation damage." Thesis, Cape Technikon, 2004. http://hdl.handle.net/20.500.11838/1461.

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Thesis (MTech (Biomedical Technology))--Cape Technikon, Cape Town, 2004<br>The need for radiobiological research was bom from the discovery that high doses of radiation could cause cancer and other health effects. However, recent developments in molecular biology uncovered the effects of low doses of radiation on different biological systems and as a result new techniques have been developed to measure these effects. The aim of this study was thus to validate biomarkers of initial DNA strand breaks, micronucleus formation, and the different pt ;ases of apoptosis as biological indic
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Ferraro, Rudy. "Development of Test Methods for the Qualification of Electronic Components and Systems Adapted to High-Energy Accelerator Radiation Environments." Thesis, Montpellier, 2019. http://www.theses.fr/2019MONTS118.

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Le Grand collisionneur de hadrons (LHC), le plus grand et le plus puissant au monde, a démarré en 2008 et constitue la dernière étape du complexe des accélérateurs du CERN. Le LHC consiste en un anneau de 27 kilomètres d'aimants supraconducteurs permettant d'accélérer deux faisceaux jusqu'à 7 TeV avant de les faire entrer en collision à 14 TeV dans l'une des cinq expériences de contrôle du résultat de la collision. Le LHC a notamment permis la découverte du boson de Higgs et d'autres particules baryoniques prédites par le modèle standard. L'environnement de rayonnement du LHC et de ses lignes
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Erekson, David McConkie. "Scheduled Healing: The Relationship Between Session Frequency and Psychotherapy Outcome in a Naturalistic Setting." BYU ScholarsArchive, 2013. https://scholarsarchive.byu.edu/etd/4037.

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The dose-effect relationship in psychotherapy has been examined extensively, but few studies have included session frequency as a component of psychotherapy "dose." Those studies that have examined the effects of session frequency have indicated that it may affect both the total amount of recovery and the speed of recovery. No studies were found examining the clinical significance of this construct in a naturalistic setting. The change trajectories of 16,003 clients were examined using multi-level modeling and including session frequency as a fixed effect. Of these clients, subgroups were ide
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Jaillet, Cyprien. "Modifications du glycome endothélial vasculaire dans le contexte d'une irradiation à forte dose." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066021/document.

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La radiothérapie constitue l’un des principaux traitements pour l’éradication des cancers. Cependant, elle présente un risque d’effets secondaires aux tissus sains environnant la tumeur. Dans ce processus, le système vasculaire et plus particulièrement l’endothélium jouent un rôle clé. Les cellules endothéliales activées favorisent le recrutement chronique des thrombocytes et des leucocytes, contribuant ainsi aux effets secondaires. D’autre part, dans les maladies inflammatoires, les glycanes exprimés à la surface des cellules endothéliales sont modifiés et influencent le recrutement des cellu
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Books on the topic "Dole effect"

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1946-, Calabrese Edward J., ed. Biological effects of low level exposures: Dose-response relationships. Lewis Publishers, 1994.

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National Council on Radiation Protection and Measurements., ed. Evaluation of the linear-nonthreshold dose-response model for ionizing radiation. National Council on Radiation Protection and Measurements, 2001.

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I, Rudnev M., and Akademii͡a︡ medychnykh nauk Ukraïny, eds. Vlii͡a︡nie nizkikh doz ionizirui͡u︡shcheĭ radiat͡s︡ii i drugikh faktorov okruzhai͡u︡shcheĭ sredy na organizm. Nauk. dumka, 1994.

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National Council on Radiation Protection and Measurements. The relative biological effectiveness of radiations of different quality: Recommendations of the National Council on Radiation Protection and Measurements. The Council, 1990.

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A, Mettler Fred. Medical effects of ionizing radiation. 2nd ed. W.B. Saunders, 1995.

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National Research Council (U.S.). Committee to Assess Health Risks from Exposure to Low Level of Ionizing Radiation, ed. Health risks from exposure to low levels of ionizing radiation : BEIR VII Phase 2. National Academies Press, 2006.

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G, Grigorʹev I͡U︡, ed. Somaticheskie ėffekty khronicheskogo gamma-obluchenii͡a︡. Ėnergoatomizdat, 1986.

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L, Sanders Charles. Radiation hormesis and the linear-no-threshold assumption. Springer, 2010.

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1938-, Lasagna Louis, Erill Sergio, and Naranjo Claudio, eds. Dose-response relationships in clinical pharmacology: Proceedings of the Esteve Foundation Symposium III. : Dose-response relationships in man, Son Vida, Mallorca, 13-15 October 1988. Excerpta Medica, 1989.

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Colloque Les Relations dose-effet de l'alcool (1984 Esclimont, France). Colloque Les Relations dose-effet de l'alcool: Esclimont, France, 20-21 mars 1984. Documentation française, 1985.

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Book chapters on the topic "Dole effect"

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Tallarida, Ronald J., Robert B. Raffa, and Paul McGonigle. "Dose-Effect Relations." In Springer Series in Pharmacologic Science. Springer New York, 1988. http://dx.doi.org/10.1007/978-1-4612-3778-5_2.

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van der Kogel, Albert J., and Michael C. Joiner. "The dose-rate effect." In Basic Clinical Radiobiology. CRC Press, 2018. http://dx.doi.org/10.1201/9780429490606-13.

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van der Kogel, Albert J., and Michael C. Joiner. "The dose-rate effect." In Basic Clinical Radiobiology, 6th ed. CRC Press, 2024. http://dx.doi.org/10.1201/9781003278337-13.

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Messenger, George C., and Milton S. Ash. "Dose-Rate Effects." In The Effects of Radiation on Electronic Systems. Springer Netherlands, 1986. http://dx.doi.org/10.1007/978-94-017-5355-5_7.

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Simola, Nicola, Micaela Morelli, Tooru Mizuno, et al. "Drug (Dose)-Effect Function (Curve)." In Encyclopedia of Psychopharmacology. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_1086.

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Cherruault, Y. "Relations Between Dose and Effect." In Mathematical Modelling in Biomedicine. Springer Netherlands, 1986. http://dx.doi.org/10.1007/978-94-009-5492-2_5.

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Fiedler, H. "High-Dose-Hook-Effekt." In Lexikon der Medizinischen Laboratoriumsdiagnostik. Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-49054-9_1446-1.

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Fiedler, H. "High-Dose-Hook-Effekt." In Springer Reference Medizin. Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_1446.

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Kalra, Mannudeep K., and Thomas L. Toth. "Patient Centering in MDCT: Dose Effects." In Radiation Dose from Multidetector CT. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/174_2011_447.

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Sapareto, Stephen A. "Practical concepts of thermal dose." In Thermal Effects on Cells and Tissues. CRC Press, 2023. http://dx.doi.org/10.1201/9780429070365-8.

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Conference papers on the topic "Dole effect"

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Stevens, Russell, and Dorian L. Johnson. "Total Non-Ionizing Dose Characterization of Microchip LX7720." In 2024 IEEE Radiation Effects Data Workshop (REDW) (in conjunction with 2024 NSREC). IEEE, 2024. http://dx.doi.org/10.1109/redw61286.2024.10759210.

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Prahardi, R., and Arundito Widikusumo. "Zero Dose." In Seminar Si-INTAN. Badan Pengawas Tenaga Nuklir, 2021. http://dx.doi.org/10.53862/ssi.v1.062021.008.

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Ionizing radiation in the medical world has long been used, both for diagnostic and therapeutic purposes. But the use of ionizing radiation, besides helping a lot in diagnosis and therapy, ionizing radiation is also hazardous for us. The effects of ionizing radiation on humans are divided into two types, namely stochastic effects, and non-stochastic (deterministic) effects. Of the two kinds of effects caused by ionizing radiation, the stochastic effect needs special attention. Because the dose-limiting parameter does not exist, how much radiation dose can cause the stochastic effect. We only h
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Bartoloni, Alessandro, and Lidia Strigari. "Dose-effects models for space radiobiology: An overview on dose-effect relationships." In RAD Conference. RAD Centre, 2022. http://dx.doi.org/10.21175/rad.sum.abstr.book.2022.25.1.

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Pease, Ronald, Gary Dunham, and John Seiler. "Total Dose and Dose Rate Response of Low Dropout Voltage Regulators." In 2006 IEEE Radiation Effects Data Workshop. IEEE, 2006. http://dx.doi.org/10.1109/redw.2006.295473.

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Bogorad, Alexander L., Justin J. Likar, Stephen K. Moyer, Audrey J. Ditzler, Graham P. Doorley, and Roman Herschitz. "Total Ionizing Dose and Dose Rate Effects in Candidate Spacecraft Electronic Devices." In 2008 IEEE Radiation Effects Data Workshop. IEEE, 2008. http://dx.doi.org/10.1109/redw.2008.29.

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Wang, Zujun, Zhigang Xiao, Baoping He, Shaoyan Huang, Benqi Tang, and Minbo Liu. "Total Dose Radiation Effects on COTS Array CCDs at Low Dose Rate." In 2014 IEEE Radiation Effects Data Workshop (REDW). IEEE, 2014. http://dx.doi.org/10.1109/redw.2014.7004605.

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Hansen, D. L., M. J. Robinson, and F. Lu. "Total-Dose Effects in InP Devices." In 2007 IEEE Radiation Effects Data Workshop. IEEE, 2007. http://dx.doi.org/10.1109/redw.2007.4342542.

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Harris, Richard D., Steven S. McClure, Bernard G. Rax, et al. "ELDRS Characterization for a Very High Dose Mission." In 2010 Radiation Effects Data Workshop. IEEE, 2010. http://dx.doi.org/10.1109/redw.2010.5619505.

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Avery, Keith, Jeffery Finchel, Jesse Mee, et al. "Total Dose Test Results for CubeSat Electronics." In 2011 IEEE Radiation Effects Data Workshop. IEEE, 2011. http://dx.doi.org/10.1109/redw.2010.6062504.

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Chen, Dakai, James D. Forney, Ronald L. Pease, et al. "The Effects of ELDRS at Ultra-Low Dose Rates." In 2010 Radiation Effects Data Workshop. IEEE, 2010. http://dx.doi.org/10.1109/redw.2010.5619506.

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Reports on the topic "Dole effect"

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Abdulla, Sara, and Jack Corrigan. Bayh-Dole Patent Trends. Center for Security and Emerging Technology, 2023. http://dx.doi.org/10.51593/20230012.

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This brief examines trends in patents generated through federally funded research, otherwise known as Bayh-Dole patents. We find that while Bayh-Dole patents make up a small proportion of U.S. patents overall, they are much more common in certain fields, especially in biosciences and national defense related fields. Academic institutions are major recipients of Bayh-Dole patents, and the funding landscape for patent-producing research has shifted since Bayh-Dole came into effect in 1980.
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Li, Xiao, GX Xu, FY Ling, et al. The dose-effect association between electroacupuncture sessions and its effect on chronic migraine: a protocol of a meta-regression of randomized controlled trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.12.0085.

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Review question / Objective: We will use a meta-regression approach to verify the dose-effect relationship between the number of electroacupuncture sessions and its effects on migraine. Condition being studied: Migraine is recurrent and chronic, requiring long-term control, but the side effects caused by long-term use limit the use of pharmacotherapy, like non-steroidal anti-inflammatory drugs (NSAIDS), ergoamines and opioids. With fewer side effects and lower cost, acupuncture is becoming a more attractive option for migraine. Relevant studies have confirmed the clinical effects of electroacu
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Lertchirakarn, Veera, and Prasit Pavasant. The effects of fluocinolone acetonide on human cultured dental pulp cell in vitro. Chulalongkorn University, 2008. https://doi.org/10.58837/chula.res.2008.15.

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The purpose of treatment of pulpal exposure is to preserve vitality, healthy and promote healing of exposed pulp tissue. Fluocinolone acetonide (FA) may have a potential to promote tissue healing. The aim of this study was therefore to investigate the effects of FA on human cultured dental pulp cell in vitro. The MTT assay was performed to examine both cytotoxicity and prolifration of FA at 24, 48 and 72 hours. The results revealed that FA (0.1 to 50 [mu]M) had no cytotoxicity effect. In addition, these doses also stimulated cell proliferation. There was a significant increase of cell prolifer
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Jordan, Jacob. On-treatment changes in pediatric parameningeal rhabdomyosarcoma treated with upfront proton therapy. University of Tennessee Health Science Center, 2022. http://dx.doi.org/10.21007/com.lsp.2022.0008.

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The project is focused on the effects of longitudinal changes in patient and tumor anatomy on the delivered treatment plan during proton radiotherapy for the treatment of pediatric Para meningeal rhabdomyosarcoma. The study will investigate the effects of change on dose delivered to organs-at-risk near the tumor. This effort will extend the analysis of changes to the organs-at-risk to all the cases in the study and add an additional case meeting the study criteria.
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Worgul, B. V. Low dose neutron late effects: Cataractogenesis. Office of Scientific and Technical Information (OSTI), 1991. http://dx.doi.org/10.2172/5816375.

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Azmy, Y. Y. Effect of Workbench Shielding on Nagasaki Factory Workers' Dose. Office of Scientific and Technical Information (OSTI), 2001. http://dx.doi.org/10.2172/777636.

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Sopori, Mohan L. Neuroimmune Effects of Inhaling Low Dose Sarin. Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada442264.

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Brust. L51576 Crack Growth Behavior and Modeling. Pipeline Research Council International, Inc. (PRCI), 1989. http://dx.doi.org/10.55274/r0010642.

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The objective of the Crack Growth/Modeling effort of the NG-18 Line Pipe Supervisory Committee's Stress-Corrosion Phase is to develop an understanding of the factors that control stress-corrosion crack growth. This information can be used to develop models for predicting crack growth and to mitigate crack growth through control of metallurgical parameters and operating conditions. This effort has been divided into the following four main tasks: (1) Characterization of crack shape,(2) Identification of a crack force driving parameter,(3) Determination of the effects of mechanical properties on
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E, Flemyng, and Mitchell D. Increased versus stable doses of inhaled steroids for exacerbations of chronic asthma in adults and children: Protocol. Epistemonikos Interactive Evidence Synthesis, 2022. http://dx.doi.org/10.30846/ies.b984bf9656.v3.

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Abstract Rationale Early treatment of asthma exacerbations with inhaled corticosteroids is the best strategy for management, although use of an increased or stable dose is questioned. Objectives To compare the clinical effectiveness and safety of increased versus stable doses of inhaled corticosteroids as part of a patient-initiated action plan for the home management of exacerbations in children and adults with persistent asthma. Search methods We searched the Cochrane Airways Group Specialised Register (part of CENTRAL), MEDLINE, Embase, CINAHL, major trials registries and handsearched abstr
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E, Flemyng, and Mitchell D. Increased versus stable doses of inhaled steroids for exacerbations of chronic asthma in adults and children: Protocol. Epistemonikos Interactive Evidence Synthesis, 2022. http://dx.doi.org/10.30846/ies.b984bf9699.v2.

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Abstract:
Abstract Rationale Early treatment of asthma exacerbations with inhaled corticosteroids is the best strategy for management, although use of an increased or stable dose is questioned. Objectives To compare the clinical effectiveness and safety of increased versus stable doses of inhaled corticosteroids as part of a patient-initiated action plan for the home management of exacerbations in children and adults with persistent asthma. Search methods We searched the Cochrane Airways Group Specialised Register (part of CENTRAL), MEDLINE, Embase, CINAHL, major trials registries and handsearched abstr
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