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Dissertations / Theses on the topic 'Dopamine receptors'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

Hilditch, A. "Pharmacological characterisation of peripheral dopamine receptors." Thesis, Open University, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.352607.

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2

Kim, Douglas S. "Dopamine and adenosine receptor function in adult and developing dopamine-deficient mice /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/5063.

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3

Obray, J. Daniel. "Peripheral Dopamine 2 Receptors Both Modulate Central Dopamine Release and Adopt in a Similar Manner to that of Central Dopamine 2 Receptors." BYU ScholarsArchive, 2020. https://scholarsarchive.byu.edu/etd/8983.

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Alcohol use disorder is a debilitating disorder affecting nearly 5% of people in the United States. Despite the prevalence of alcohol use disorder few affected individuals seek treatment and of those who do many will relapse. This highlights a need to develop new treatments for alcohol use disorder that are both more accessible and more effective. This dissertation characterizes a novel pathway involved in ethanol enhancement of dopamine levels in the nucleus accumbens as well as investigating alterations in dopamine 2 receptor expression and function following an acute dose of ethanol. This w

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4

Evans, Anthony Mark. "Dopamine receptors of the cockroach salivary gland." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/27986.

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A study has been made of the secretory response and the electrical reponse (a hyperpolarization followed by a depolarization) mediated by dopamine receptors of the cockroach (<i>Nauphoeta cinerea</i> Olivier) salivary gland <i>in-vitro</i>. Although domperidone did not inhibit the electrical response to dopamine, three other actions were observed: one, post-synaptic, led to the potentiation of the hyperpolarization; this action was shared by (±)sulpiride. A separate post-synaptic action resulted in the inhibition of the depolarizing phase of the response. Finally a pre-synaptic action led to t

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5

Hollis, Clare M. "Central and peripheral Dâ†1 dopamine receptors." Thesis, University of Kent, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292301.

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6

Clark, Kenneth Lyle. "Pharmacology of renal dopamine and angiotensin receptors." Thesis, Open University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293275.

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Dopamine and angiotensin II (Ang II) are naturally occurring molecules with profound but contrasting effects in the kidney. This study aimed to increase knowledge of the pharmacology and physiology of renal dopamine and angiotensin receptors. Little evidence was found to the presence of dopamine DA1 receptors, mediating dilatation, or angiotensin receptors, mediating constriction, in canine isolated main branch, interlobar, or arcuate renal artery rings. However, in anaesthetised dogs, renal vascular angiotensin and dopamine receptors were clearly demonstrated, suggesting that they are located

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7

Torvinen, Maria. "Adenosine receptor/dopamine receptor interactions : molecular and biochemical aspects /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-298-1/.

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8

Tong, Huaxia. "Modulation of NMDA receptor activity by dopamine receptors in the rat striatum." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445880/.

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NMDA receptors are of particular importance in the control of synaptic strength and integration of synaptic activity. Dopamine receptor modulation of NMDA receptors in the striatum may influence the efficacy of synaptic transmission in the cortico-striatal pathway (Calabresi et al., 2000c Centonze et al., 2003) and if so, this modulation will be lost in Parkinson's disease. This change may be an important factor in the changes in the basal ganglia neural network that occur in Parkinson's Disease. In this thesis I have studied dopamine D1 and D2 receptor modulation of NMDA receptors in medium s

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9

Heusner, Carrie L. "Genetic analysis of striatal glutamate-dopamine interactions /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/9212.

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10

Oak, James N. "Characterization of epitope-tagged dopamine D¦4 receptors." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0001/MQ45554.pdf.

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11

Harper, Laura. "A[2A subscript] adenosine receptors, dopamine and reward." Thesis, University of Nottingham, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408638.

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12

Maguire-Robinson, Nicola Jane. "Expression and analysis of Dâ†2 dopamine receptors." Thesis, University of Kent, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311283.

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13

Wallace, Raye Ann. "The interaction of structural analogs of dopamine, chlorpromazine and sulpiride with striatal dopamine receptors /." The Ohio State University, 1987. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487586889186522.

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14

Castro, Diogo Sampaio e. "Functional studies on the orphan receptor Nurr1 and related retinoid receptors /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4608-6/.

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15

Worrall, S. "The purification of D2Ì² dopamine receptors from bovine striatum." Thesis, University of Nottingham, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377448.

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16

Abbott, W. M. "Immunological studies and partial purification of brain dopamine receptors." Thesis, University of Nottingham, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371990.

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17

Borcherding, Dana. "Human Adipocytes: Dopamine Receptors and the Regulation of Prolactin." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1289945037.

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18

Kalani, M. Yashar S. Gray Harry B. "Structure and function studies of the human dopamine receptors /." Diss., Pasadena, Calif. : California Institute of Technology, 2004. http://resolver.caltech.edu/CaltechETD:etd-05042004-203854.

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19

Middleton, Lisa Sue. "NICOTINIC RECEPTOR MODULATION OF DOPAMINE TRANSPORTERS." UKnowledge, 2006. http://uknowledge.uky.edu/gradschool_diss/412.

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The current project examined the ability of nicotine to modulate dopamine transporter (DAT) function. Initial experiments determined the dose-response for nicotine to modulate dopamine (DA) clearance in rat striatum and medial prefrontal cortex (MPFC) using in vivo voltammetry and determined if this effect was mediated by nicotinic receptors (nAChRs). In both striatum and MPFC, nicotine increased DA clearance in a mecamylamine-sensitive manner, indicating nAChR-mediation. The effect of acute nornicotine on DAT function was also determined. In contrast to nicotine, nornicotine in a dose-related

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20

Nkemdirim, Arinzechukwu Okere. "Effect of Melatonin and Dopamine in Site Specific Phosphorylation of Phosducin in Intact Retina." BYU ScholarsArchive, 2005. https://scholarsarchive.byu.edu/etd/758.

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Phosducin (Pdc) is a 28 kDa binding partner for the G protein beta gamma subunit dimer (G-beta-gamma) found abundantly in the photoreceptor cells of the retina and pineal gland. In the retina, light-dependent changes in cAMP and Ca2+ control the phosphorylation of Pdc at serine 73 and 54, respectively, which in turn controls the binding of Pdc to G protein beta gamma subunit dimer . G protein beta gamma subunit dimer binding has been proposed to facilitate light-driven transport of G protein beta gamma subunit dimer from the site of phototransduction in the outer segment of the photoreceptor c

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21

謝志恒 and Chi-hang Tse. "Molecular cloning of the goldfish dopamine D2 receptor." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B42128511.

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22

Sánchez, Soto Marta. "Noncanonical Neurotransmitter Activation of Catecholamine Receptors." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/400298.

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From the D2‐like receptors (D2,D3, D4), only D4 receptor (D4R) has been described as “promiscuous” since it can be activated both by dopamine (DA) and norepinephrine (NE) and function as a noradrenergic receptor in the brain. However, there is no evidence for the other D2‐like receptors. In addition, D4R has a large number of polymorphisms, one of the variants, D4.7, has been associated with several neuropsychiatric disorders. The first aim of this thesis was to study the possible activation of D2‐like recptors (including the three main D4 variants, D2 short, D2 long and D3) by radiolab

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23

Baxter, Andrew Douglas. "Enantioselective synthesis of aminotetralins : novel synthetic applications of amino acids." Thesis, University of East Anglia, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359328.

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24

Casadó, Anguera Verònica. "Allosteric interactions between catecholamine receptors and other G protein-coupled receptors: Pharmacological and functional characterization." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/586262.

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Catecholamines, including dopamine (DA) and norepinephrine (NE), are widely distributed in the body and constitute a class of conventional neurotransmitters and hormones that occupy key positions in the regulation of physiological processes and in the development of neurological, psychiatric, endocrine and cardiovascular diseases. There is a linkage between a variety of genes related to DA (e.g. D4 receptor) and NE (e.g. α2A-adrenoceptor) and the vulnerability for developing attention deficit hyperactivity disorder (ADHD), which is characterized by pervasive symptoms of inattention, impulsivit

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25

Sickler, Thaís de Paula. "Análise da expressão da filamina A nos tumores hipofisários e suas implicações clínicas e terapêuticas." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-08052018-083923/.

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A filamina A (FLNA) é uma proteína de citoesqueleto com diversas funções, dentre as quais estão motilidade celular e ancoragem de receptores de membrana. A alteração de sua expressão foi anteriormente descrita em diversos tipos de neoplasia. Em tumores hipofisários, demonstrou-se que sua expressão se correlacionou à expressão de receptores de dopamina tipo 2 (DRD2) em prolactinomas, e com a sinalização intracelular do receptor de somatostatina tipo 2 (SSTR2) após ativação por agonista, em somatotropinomas. Neste estudo, avalariam-se a expressão da FLNA, DRD2, SSTR2 e SSTR5 em diversos tumores

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26

SANTOS, Anderson Felipe da Silva. "Expressão tecidual dos receptores dopaminérgicos D1 no Núcleo Accumbens e estriado de ratas desnutridas." Universidade Federal de Pernambuco, 2015. https://repositorio.ufpe.br/handle/123456789/16607.

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Submitted by Fabio Sobreira Campos da Costa (fabio.sobreira@ufpe.br) on 2016-04-15T14:05:59Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Dissertação_AndersonFelipe_Versão Final.pdf: 4770513 bytes, checksum: bd8c869ddc087cfbf7bc953f303cf9e5 (MD5)<br>Made available in DSpace on 2016-04-15T14:05:59Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Dissertação_AndersonFelipe_Versão Final.pdf: 4770513 bytes, checksum: bd8c869ddc087cfbf7bc953f303cf9e5 (MD5) Previous issue date: 2015-08-21<

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27

Kostrzewa, Richard M., John P. Kostrzewa, Russell W. Brown, Przemyslaw Nowak, and University of Silesia Ryszard Brus Medical. "Dopamine Receptor Supersensitivity: Development, Mechanisms, Presentation, and Clinical Applicability." Digital Commons @ East Tennessee State University, 2008. https://doi.org/10.1007/BF03033804.

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The process of receptor supersensitivity (RSS) has a long history and is an epiphenomenon of neuronal denervation. Dopamine (DA) RSS (DARSS) similarly occurs after DA denervation, and this process is invoked in neuropsychiatric and neurodegenerative disorders. From studies largely over the past 25 years, much has been learned regarding DARSS. For example, overt D1 DARSS occurs after perinatal destruction of nigrostriatal DA fibers. However, following perinatal destruction of DA innervation, the most-prominent behavioral effects of a D1 agonist are observed after a series of D1 agonist treatmen

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28

Ng, Gordon Y. K. "Biochemical and pharmacological studies on dopamine D1 and D2L receptors." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1996. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ35444.pdf.

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29

Lane, Jonathan R. D. "The G protein-coupling specificity of D2-like dopamine receptors." Thesis, University of Glasgow, 2007. http://theses.gla.ac.uk/30/.

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The G-protein coupling specificity of D2-like dopamine receptors was investigated using both receptor-G protein fusions and membranes of cells in which pertussis toxin-resistant mutants of individual Gi-family G proteins could be expressed in an inducible fashion. A range of ligands displayed agonism at the long isoform of the human dopamine D2 receptor. However, varying degrees of efficacy were observed for individual ligands as monitored by their capacity to load [35S] GTPγS onto each of Gi1, Gi2, Gi3 and Go1. By contrast, S-(-)-3-(3-hydroxyphenyl)-N-propylpiperidine (S-(-)-3PPP) was a parti

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30

Gutierrez, Arnold. "The role of dopamine receptors in methamphetamine-induced cognitive deficits." University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1521189209471948.

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31

Castelo-Branco, Gonçalo de Sá e. Sousa de. "Wnt signalling in the development of ventral midbrain dopaminergic neurons /." Stockholm, 2004. http://diss.kib.ki.se/2005/91-7140-176-8/.

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32

Gravel, Paul. "Positron emission tomography of extra-striatal dopamine release." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112625.

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Altered dopamine (DA) neurotransmission is implicated in neurological and psychiatric disorders. Positron Emission Tomography (PET) imaging of DA release has mainly been restricted to striatal areas, rich in D2/D 3 receptors, owing to the moderate affinity of the radioligands used. To measure extra-striatal DA release, where D2/D3 receptor concentrations are much smaller, an approach using a high affinity radioligand, such as [18F]Fallypride, is required. The aim of the present study was to investigate in healthy volunteers the suitability of [ 18F]Fallypride to measure variations in D2/D3 rec

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33

Rodvelt, Kelli Renee. "Acute & subchronic NMDA receptor blockade alters nicotine-evoked dopamine release." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/5060.

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Thesis (M.A.)--University of Missouri-Columbia, 2007.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on April 10, 2009) Includes bibliographical references.

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34

Leonard, M. N. "Studies on the potential heterogeneity of D2Ì² dopamine receptors from bovine and rat brain." Thesis, University of Nottingham, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381474.

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35

Mason, Sarah. "Post-mortem neuropharmacological studies of human and rat brain relating to schizophrenia and antipsychotic drug action." Thesis, University of Sheffield, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364237.

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36

Hara, Yuko. "Dopamine-dependent plasticity and subcellular locations of dopamine D1 receptors : in relation to glutamate NMDA receptors and endogenous opioids in the nucleus accumbens, implications for schizophrenia /." Access full-text from WCMC, 2008. http://proquest.umi.com/pqdweb?did=1528441261&sid=22&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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37

Kruse, Maria Sol. "Plasticity of the dopamine 1 receptor and its signaling pathway /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-652-9/.

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38

Gardner, B. "Elucidating the mechanisms of agonist action at Dâ†2 dopamine receptors." Thesis, University of Kent, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283973.

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39

Marston, Deborah Louise. "Expression and characterisation of dopamine Dâ†2â†S and olfactory receptors." Thesis, University of Reading, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339980.

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40

Avalos, Melva Nidia. "Partial agonist interactions with dopamine in clonal cell lines expressing recombinant receptors : towards a molecular model of antipsychotic drug action /." Digital version accessible at:, 1999. http://wwwlib.umi.com/cr/utexas/main.

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41

Karasinska, Joanna Monika. "Functional interactions of D1 and D3 dopamine receptors, generation and behavioural assessment of mice lacking both receptors." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0023/MQ50451.pdf.

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42

Romanholi, Daniella de Jesus Patrick Carminatti. "Efeito da administração de octreotide, cabergolina e a associação de ambos nos níveis de ACTH e cortisol em pacientes com doença de Cushing: correlação da resposta clínica com a expressão tumoral dos receptores de dopamina (DRD2) e de somatostatina (SSTR2 e SSTR5)." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-21092010-095750/.

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Introdução: A doença de Cushing apresenta elevada morbimortalidade. Seu tratamento de escolha é a cirurgia transesfenoidal que possui resultados satisfatórios em cerca de 70% dos casos. Na doença persistente ou recorrente, reabordagem cirúrgica, radioterapia e adrenalectomia bilateral podem ser realizadas, porém, essas opções apresentam como desvantagens o desenvolvimento de hipopituitarismo e a dependência de terapia de reposição. Até o momento, nenhuma droga tem se mostrado eficaz no tratamento do corticotrofinoma. Os esquemas terapêuticos mais eficazes são os inibidores da esteroidogênese q

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43

Andersson, Daniel. "Dopamine and the regulation of movements : significance of nigral and striatal dopamine release in normal, hemiparkinsonian and dyskinetic rats /." Göteborg : Dept. of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, 2009. http://hdl.handle.net/2077/19327.

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44

Karper, Patrick Eugene. "Role of the Dopamine D₁-like receptor in amphetamine-induced behavioral sensitization: A study using Dopamine D₁A-receptor deficient mice." CSUSB ScholarWorks, 2000. https://scholarworks.lib.csusb.edu/etd-project/1682.

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The ability of the indirect dopamine agonist, amphetamine, to produce behavioral sensitization was assessed in adult D₁A-deficient and wild-type mice. It was originally predicted that : 1) dopamine (DA) D₁-like receptors are necessary for the occurrence of short- and long-term amphetamine-induced behavioral sensitization, 2) DA D₁-like receptors are necessary for environmental conditioning factors associated with amphetamine-induced behavioral sensitiazation, and 3) DA D₅ receptors are required for amphetamine-induced behavioral sensitization. Locomotor activity and sterotyped sniffing were as

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45

Sousa, Kyle Matthew. "Nuclear receptor and Wnt function in developing dopaminergic neurons /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-105-0/.

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46

Zhang, Boyang. "Functional and Structural Insights into the First and Second Intracellular Domains for D1-Class Dopaminergic Receptors." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/35932.

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Previous studies have shown that the subtype-specific pharmacological properties of D1-class receptors (D1R and D5R) can be attributed to their third intracellular domain and C-terminal tail. However, the importance of their first and second intracellular domains (IC1 and IC2) has yet to be explored. Using mutagenesis and bioinformatics, we examine the functional and structural roles of Ser/Thr spanning IC1 and IC2—most of which are conserved not only among D1-class receptors but also among other GPCRs. Mutant receptors of human D1-class receptors (hD1R and hD5R) were constructed whereby all S

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47

Gong, Li. "Co-sensitization of Dopamine and Serotonin Receptors Occurs in the Absence of a Change in the Dopamine D1 Receptor Complex After a Neonatal 6-ohda Lesion." Digital Commons @ East Tennessee State University, 1993. https://dc.etsu.edu/etd/2686.

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To test whether SKF 38393 could ontogenetically sensitize dopamine (DA) D$\sb1$ receptors and whether this sensitization would be associated with biochemical changes, intact and neonatal 6-hydroxydopamine (6-OHDA)-lesioned rats (200 $\mu$g i.c.v.) were treated daily from birth with SKF 38393 (3.0 mg/kg i.p. x 28 days) or its vehicle. In DA D$\sb1$ neonatally sensitized 6-OHDA rats, enhanced locomotor responses were observed with the first SKF 38393 challenge dose (3.0 mg/kg i.p.) at 6 weeks. This response increased further with weekly SKF 38393 treatments. Enhanced stereotyped behaviors were s

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48

Terasmaa, Anton. "Dopamine D2 receptor G protein coupling and its regulation /." Stockholm, 2003. http://diss.kib.ki.se/2004/91-7349-788-6/.

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49

Sóvágó, Judit. "Methodological advances in the examination of the dopamine system in brain /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-552-6/.

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50

Mestlin, Monja. "Effects of dopamine D1 and D2 receptor inactivation on locomotor activity and sniffing in 11- and 17-day-old rats." CSUSB ScholarWorks, 1992. https://scholarworks.lib.csusb.edu/etd-project/785.

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