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Journal articles on the topic 'Dopamine receptors'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

Jose, P. A., J. R. Raymond, M. D. Bates, A. Aperia, R. A. Felder, and R. M. Carey. "The renal dopamine receptors." Journal of the American Society of Nephrology 2, no. 8 (1992): 1265–78. http://dx.doi.org/10.1681/asn.v281265.

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Dopamine is an endogenous catecholamine that modulates many functions including behavior, movement, nerve conduction, hormone synthesis and release, blood pressure, and ion fluxes. Dopamine receptors in the brain have been classically divided into D1 and D2 subtypes, based on pharmacological data. However, molecular biology techniques have identified many more dopamine receptor subtypes. Several of the receptors cloned from the brain correspond to the classically described D1 and D2 receptors. Several D1 receptor subtypes have been cloned (D1A, D1B, and D5) and are each coupled to the stimulat

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Hussain, Tahir, and Mustafa F. Lokhandwala. "Renal Dopamine Receptors and Hypertension." Experimental Biology and Medicine 228, no. 2 (2003): 134–42. http://dx.doi.org/10.1177/153537020322800202.

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Dopamine has been recognized as an important modulator of central as well as peripheral physiologic functions in both humans and animals. Dopamine receptors have been identified in a number of organs and tissues, which Include several regions within the central nervous system, sympathetic ganglia and postganglionic nerve terminals, various vascular beds, the heart, the gastrointestinal tract, and the kidney. The peripheral dopamine receptors influence cardiovascular and renal function by decreasing afterload and vascular resistance and promoting sodium excretion. Within the kidney, dopamine re

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3

Awenowicz, Patrick W., and Linda L. Porter. "Local Application of Dopamine Inhibits Pyramidal Tract Neuron Activity in the Rodent Motor Cortex." Journal of Neurophysiology 88, no. 6 (2002): 3439–51. http://dx.doi.org/10.1152/jn.00078.2002.

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Cortical neurons respond in a variety of ways to locally applied dopamine, perhaps because of the activation of different receptors within or among subpopulations of cells. This study was conducted to assess the effects of dopamine and the receptor subtypes that mediate the responses of a specific population of neurons, the pyramidal tract neurons (PTNs) in the rodent motor cortex. The specific subfamilies of dopamine receptors expressed by PTNs also were determined. PTNs were identified by antidromic stimulation in intact animals. Extracellular recordings of their spontaneous activity and glu

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Felder, R. A., C. C. Felder, G. M. Eisner, and P. A. Jose. "The dopamine receptor in adult and maturing kidney." American Journal of Physiology-Renal Physiology 257, no. 3 (1989): F315—F327. http://dx.doi.org/10.1152/ajprenal.1989.257.3.f315.

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Dopamine, like other neurotransmitters, exerts its biological effects by occupation of specific receptor subtypes. The dopamine receptors in the central nervous system and certain endocrine organs are classified into the D1/D2 subtypes. Outside the central nervous system, the dopamine receptors are classified into the DA1/DA2 subtypes. The D1/D2 and DA1/DA2 receptor have marked similarities and some differences, the most notable of which is the lower affinity of the DA dopamine compared with the D dopamine receptor. DA1 receptor activation increases renal blood flow (RBF); stimulation of DA1 a

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Yamamoto, Kei, Romain Fontaine, Catherine Pasqualini, and Philippe Vernier. "Classification of Dopamine Receptor Genes in Vertebrates: Nine Subtypes in Osteichthyes." Brain, Behavior and Evolution 86, no. 3-4 (2015): 164–75. http://dx.doi.org/10.1159/000441550.

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Dopamine neurotransmission regulates various brain functions, and its regulatory roles are mediated by two families of G protein-coupled receptors: the D1 and D2 receptor families. In mammals, the D1 family comprises two receptor subtypes (D1 and D5), while the D2 family comprises three receptor subtypes (D2, D3 and D4). Phylogenetic analyses of dopamine receptor genes strongly suggest that the common ancestor of Osteichthyes (bony jawed vertebrates) possessed four subtypes in the D1 family and five subtypes in the D2 family. Mammals have secondarily lost almost half of the ancestral dopamine

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Chazot, P. L., A. J. Doherty, and P. G. Strange. "Antisera specific for D2 dopamine receptors." Biochemical Journal 289, no. 3 (1993): 789–94. http://dx.doi.org/10.1042/bj2890789.

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Antisera have been raised against two peptides from the sequence of D2 dopamine receptors: peptide 1 from the predicted second extracellular loop and peptide 2 from the predicted third intracellular loop. The antisera recognize specifically a 95 kDa band in Western blots of several bovine brain regions, which corresponds to the denatured D2 dopamine receptor, whereas in recombinant CHO cells expressing D2 dopamine receptors a 80 kDa band is seen. The antisera immunoprecipitate 10-20% of the D2 dopamine receptors from soluble preparations of bovine brain. The antisera recognize D2 dopamine rece

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Zeng, Chunyu, and Pedro A. Jose. "Dopamine Receptors." Hypertension 57, no. 1 (2011): 11–17. http://dx.doi.org/10.1161/hypertensionaha.110.157727.

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8

Zapata, Agustin, Bronwyn Kivell, Yang Han, et al. "Regulation of Dopamine Transporter Function and Cell Surface Expression by D3 Dopamine Receptors." Journal of Biological Chemistry 282, no. 49 (2007): 35842–54. http://dx.doi.org/10.1074/jbc.m611758200.

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D3 dopamine receptors are expressed by dopamine neurons and are implicated in the modulation of presynaptic dopamine neurotransmission. The mechanisms underlying this modulation remain ill defined. The dopamine transporter, which terminates dopamine transmission via reuptake of released neurotransmitter, is regulated by receptor- and second messenger-linked signaling pathways. Whether D3 receptors regulate dopamine transporter function is unknown. We addressed this issue using a fluorescent imaging technique that permits real time quantification of dopamine transporter function in living singl

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Sunahara, Roger K., Philip Seeman, Hubert H. M. Van Tol, and Hyman B. Niznik. "Dopamine Receptors and Antipsychotic Drug Response." British Journal of Psychiatry 163, S22 (1993): 31–38. http://dx.doi.org/10.1192/s000712500029257x.

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Dopamine receptors have been divided into two major types – D1 and D2 – based primarily on pharmacological and biochemical criteria. Recent advances in the molecular biology of the dopamine receptor system have allowed the identification and characterisation of at least five distinct neuronal dopamine receptor genes (D1 to D5). These genes encode dopamine receptors belonging to the D1 receptor family, termed D1 and D5, and three D2-like receptors, termed D2, D3 and D4. These receptors are distinguished on the basis of their primary structure, chromosomal location, mRNA size and tissue distribu

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10

Myslivecek, Jaromir. "Dopamine and Dopamine-Related Ligands Can Bind Not Only to Dopamine Receptors." Life 12, no. 5 (2022): 606. http://dx.doi.org/10.3390/life12050606.

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The dopaminergic system is one of the most important neurotransmitter systems in the central nervous system (CNS). It acts mainly by activation of the D1-like receptor family at the target cell. Additionally, fine-tuning of the signal is achieved via pre-synaptic modulation by the D2-like receptor family. Some dopamine drugs (both agonists and antagonists) bind in addition to DRs also to α2-ARs and 5-HT receptors. Unfortunately, these compounds are often considered subtype(s) specific. Thus, it is important to consider the presence of these receptor subtypes in specific CNS areas as the functi

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11

Liggins, John. "Roles of Dopamine D1 and D2 Receptors in Working Memory Function." McGill Science Undergraduate Research Journal 4, no. 1 (2009): 39–45. http://dx.doi.org/10.26443/msurj.v4i1.77.

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    Dopamine has been implicated in the modulation of working memory via its interactions with circuits located in the prefrontal cortex of rodents and non-human primates. However, the role that pathways triggered by dopamine receptor subtypes play in affecting processes of working memory remains unclear. In humans, the evidence for dopaminergic modulation of working memory is controversial and the neurological substrates for dopamine’s modulatory effects are not fully understood. This paper will review the major animal and human studies that implicate synaptic dopamine

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Guidolin, Diego, Cinzia Tortorella, Manuela Marcoli, et al. "Modulation of Neuron and Astrocyte Dopamine Receptors via Receptor–Receptor Interactions." Pharmaceuticals 16, no. 10 (2023): 1427. http://dx.doi.org/10.3390/ph16101427.

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Dopamine neurotransmission plays critical roles in regulating complex cognitive and behavioral processes including reward, motivation, reinforcement learning, and movement. Dopamine receptors are classified into five subtypes, widely distributed across the brain, including regions responsible for motor functions and specific areas related to cognitive and emotional functions. Dopamine also acts on astrocytes, which express dopamine receptors as well. The discovery of direct receptor–receptor interactions, leading to the formation of multimeric receptor complexes at the cell membrane and provid

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Ashfaq, Muhammad, S. Mobasher Ali Abid, Khalid Rauf, et al. "Potential Role of Proton Pump Inhibitors Against Human DRD2 Receptor in Drug Induced Hyperprolactinemia." Revista de Chimie 71, no. 10 (2020): 182–92. http://dx.doi.org/10.37358/rc.20.10.8362.

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Dopamine is a catecholamine neurotransmitter that control several important functions via different dopamine receptors(D1-D5). The Dopamine (DRD2) receptor and other D2 family receptors (D3 and D4) are predominantly involved in the inhibitory activities. One vital role of dopamine receptors is its involvement in the endocrine regulations including the hormone synthesis and their secretion. The regulation of prolactin hormone is mainly controlled through DRD2 receptors. Blocking the delivery of dopamine at these DRD2 receptors will cause an increase in serum prolactin levels. PPI�s are among th

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Sobczuk, Paweł, Michał Łomiak, and Agnieszka Cudnoch-Jędrzejewska. "Dopamine D1 Receptor in Cancer." Cancers 12, no. 11 (2020): 3232. http://dx.doi.org/10.3390/cancers12113232.

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Dopamine is a biologically active compound belonging to catecholamines. It plays its roles in the human body, acting both as a circulating hormone and neurotransmitter. It acts through G-protein-coupled receptors divided into two subgroups: D1-like receptors (D1R and D5R) and D2-like receptors (D2R, D3R, D4R). Physiologically, dopamine receptors are involved in central nervous system functions: motivation or cognition, and peripheral actions such as blood pressure and immune response modulation. Increasing evidence indicates that the dopamine D1 receptor may play a significant role in developi

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Bates, M. D., M. G. Caron, and J. R. Raymond. "Desensitization of DA1 dopamine receptors coupled to adenylyl cyclase in opossum kidney cells." American Journal of Physiology-Renal Physiology 260, no. 6 (1991): F937—F945. http://dx.doi.org/10.1152/ajprenal.1991.260.6.f937.

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Peripheral dopamine receptors are classified as DA1 and DA2 receptors, similar to but distinct from central D1 and D2 receptors. Here we report the characterization of DA1 dopamine receptors in the opossum kidney (OK) cell line, which possesses properties of renal proximal tubule cells. OK cell membranes contain 248 +/- 12 fmol [125I]Sch 23982 binding sites/mg protein, which possess pharmacological properties appropriate for a DA1 receptor. Dopamine stimulates adenylyl cyclase via these receptors 4.3 +/- 0.4-fold (50% effective concentration = 4.0 +/- 0.7 microM). The responsiveness of this si

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Mizuta, Kentaro, Yi Zhang, Dingbang Xu, Eiji Masaki, Reynold A. Panettieri, and Charles W. Emala. "The dopamine D2 receptor is expressed and sensitizes adenylyl cyclase activity in airway smooth muscle." American Journal of Physiology-Lung Cellular and Molecular Physiology 302, no. 3 (2012): L316—L324. http://dx.doi.org/10.1152/ajplung.00130.2011.

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Dopamine receptors are G protein-coupled receptors that are divided into two subgroups, “D1-like” receptors (D1 and D5) that couple to the Gs protein and “D2-like” receptors (D2, D3, and D4) that couple to Gi. Although inhaled dopamine has been reported to induce bronchodilation in patients with asthma, functional expression of dopamine receptor subtypes has never been described on airway smooth muscle (ASM) cells. Acute activation of Gi-coupled receptors inhibits adenylyl cyclase activity and cAMP synthesis, which classically impairs ASM relaxation. In contrast, chronic activation of Gi-coupl

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17

Bannon, Michael J., and Christopher J. Whitty. "Neurokinin receptor gene expression in substantia nigra: localization, regulation, and potential physiological significance." Canadian Journal of Physiology and Pharmacology 73, no. 7 (1995): 866–70. http://dx.doi.org/10.1139/y95-119.

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Neurokinin receptor gene expression within the rat and human substantia nigra was examined in detail. In the rat, the relative abundances of nigral neurokinin receptor mRNAs were neurokinin 3 > neurokinin 1 [Formula: see text] neurokinin 2. High levels of neurokinin 3 mRNA were localized to dopamine neurons, as determined by dopamine cell lesions and colocalization with tyrosine hydroxylase mRNA. Stimulation of nigral neurokinin 3 receptors activated dopamine cells, as evidenced by increases in striatal dopamine metabolism and in a postsynaptic measure of dopamine neurotransmission (i.e., s

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18

Ricci, Alberto, Sophie Marchal-Victorion, Elena Bronzetti, Angelo Parini, Francesco Amenta, and Seyed K. Tayebati. "Dopamine D4 Receptor Expression in Rat Kidney: Evidence for Pre- and Postjunctional Localization." Journal of Histochemistry & Cytochemistry 50, no. 8 (2002): 1091–96. http://dx.doi.org/10.1177/002215540205000811.

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Dopamine D4 receptors mediate inhibition of vasopressin-dependent sodium reabsorption by dopamine in collecting tubules. At present, the distribution of D4 receptors in other renal districts remains an open issue. The renal distribution of D4 receptor was assessed in normally innervated and denervated male Sprague-Dawley rats by quantitative immunohistochemistry using an anti-dopamine D4 receptor rabbit polyclonal antibody. D4 receptor protein immunoreactivity was observed perivascularly in the adventitia and the adventitia-media border. The density of perivascular dopamine D4 receptor was hig

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Olesen, Kristin M., Heather M. Jessen, Catherine J. Auger, and Anthony P. Auger. "Dopaminergic Activation of Estrogen Receptors in Neonatal Brain Alters Progestin Receptor Expression and Juvenile Social Play Behavior." Endocrinology 146, no. 9 (2005): 3705–12. http://dx.doi.org/10.1210/en.2005-0498.

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Abstract Steroid receptor activation in developing brain influences a variety of cellular processes that endure into adulthood, altering both behavior and physiology. We report that estrogen receptors can be activated in a ligand-independent manner within developing brain by membrane dopamine receptors. Neonatal treatment with either estradiol or a dopamine D1 receptor agonist can increase the expression of an estrogen receptor-regulated gene (i.e. progestin receptors) and later juvenile social play. More importantly, increases in social play behavior induced by neonatal treatment with estradi

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Qaddumi, Waleed N., and Pedro A. Jose. "The Role of the Renal Dopaminergic System and Oxidative Stress in the Pathogenesis of Hypertension." Biomedicines 9, no. 2 (2021): 139. http://dx.doi.org/10.3390/biomedicines9020139.

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The kidney is critical in the long-term regulation of blood pressure. Oxidative stress is one of the many factors that is accountable for the development of hypertension. The five dopamine receptor subtypes (D1R–D5R) have important roles in the regulation of blood pressure through several mechanisms, such as inhibition of oxidative stress. Dopamine receptors, including those expressed in the kidney, reduce oxidative stress by inhibiting the expression or action of receptors that increase oxidative stress. In addition, dopamine receptors stimulate the expression or action of receptors that decr

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Trivedi, Meghna, Vihang A. Narkar, Tahir Hussain, and Mustafa F. Lokhandwala. "Dopamine recruits D1A receptors to Na-K-ATPase-rich caveolar plasma membranes in rat renal proximal tubules." American Journal of Physiology-Renal Physiology 287, no. 5 (2004): F921—F931. http://dx.doi.org/10.1152/ajprenal.00023.2004.

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Activation of dopamine D1A receptors in renal proximal tubules causes inhibition of sodium transporters (Na-K-ATPase and Na/H exchanger), leading to a decrease in sodium reabsorption. In addition to being localized on the plasma membrane, D1A receptors are mainly present in intracellular compartments under basal conditions. We observed, using [3H]SCH-23390 binding and immunoblotting, that dopamine recruits D1A receptors to the plasma membrane in rat renal proximal tubules. Furthermore, radioligand binding and/or immunoblotting experiments using pharmacological modulators showed that dopamine-i

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Ahangari, G., G. H. Shariati, M. R. Asadi, M. R. Ostadali, and H. R. Ahmadkhaniha. "Novel Mutation Detection of Regulatory Molecule Dopamine Gene Receptors (D1–D5) Encoding Analysis on Human Peripheral Blood Lymphocytes in Schizophrenia Patients." European Journal of Inflammation 7, no. 3 (2009): 145–52. http://dx.doi.org/10.1177/1721727x0900700304.

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There is much evidence which highlights the involvement of the dopamine system in the pathophysiology of schizophrenia. Recently, there have been reports of detected mutations in dopamine gene receptors in genomic DNA of schizophrenia. In this study, we attempt to determine whether there is mutation in encoding dopamine receptor. The PBMC was separated from whole blood by Ficoll-hypaque; the total cellular RNA was extracted and the cDNA was synthesized. This process followed by real-time PCR using primer pairs specific for five dopamine receptor mRNAs and β-actin as internal control. The resul

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Zeng, Chunyu, Meng Zhang, Laureano D. Asico, Gilbert M. Eisner, and Pedro A. Jose. "The dopaminergic system in hypertension." Clinical Science 112, no. 12 (2007): 583–97. http://dx.doi.org/10.1042/cs20070018.

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Dopamine plays an important role in the pathogenesis of hypertension by regulating epithelial sodium transport, vascular smooth muscle contractility and production of reactive oxygen species and by interacting with the renin–angiotensin and sympathetic nervous systems. Dopamine receptors are classified into D1-like (D1 and D5) and D2-like (D2, D3 and D4) subtypes based on their structure and pharmacology. Each of the dopamine receptor subtypes participates in the regulation of blood pressure by mechanisms specific for the subtype. Some receptors regulate blood pressure by influencing the centr

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Watanabe, Masayuki, Satoshi Tsuruta, Yasuhiro Inoue, et al. "Dopamine D1 and D2 receptors in spontaneously hypertensive rat brain striatum." Canadian Journal of Physiology and Pharmacology 67, no. 12 (1989): 1596–97. http://dx.doi.org/10.1139/y89-256.

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Since it has been reported that dopamine D2 receptors are elevated in the brain striatum of spontaneously hypertensive (SH) rats, and since both D1 and D2 receptors may interact with one another, we measured the densities of both these receptors in SH rat striatum, as well as those in the normotensive Wistar–Kyoto rat striatum. The D1 receptor density in both strains was virtually the same, 72.9 ± 2.2 and 71.3 ± 3.2 pmol/g, respectively (mean ± SD). The D2 receptor densities were also almost identical, 16.3 ± 0.6 and 16.8 ± 1.0 pmol/g, respectively (mean ± SD). Thus, these data do not support

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DeFrance, J. F., R. W. Sikes, and R. B. Chronister. "Dopamine action in the nucleus accumbens." Journal of Neurophysiology 54, no. 6 (1985): 1568–77. http://dx.doi.org/10.1152/jn.1985.54.6.1568.

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The action of dopamine was studied in the nucleus accumbens of acutely prepared rabbits. Dopamine was applied iontophoretically to those cells and cell populations that responded in a monosynaptic excitatory manner to ipsilateral fimbrial stimulation. This strategy was adopted to isolate the effects of dopamine on postsynaptic receptors thus avoiding the bias resulting from activation of presynaptic dopamine receptors on dopaminergic afferents. Dopamine was found to have a suppressive effect on the excitatory (N) component of the field response and on driven extracellular unitary discharges. T

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Kandasamy, Krishnaveni, Abinaya Paramanandham, Goshika Russel Suthi Kumari, and Kameswaran Ramalingam. "A comprehensive review on the role of dopamine in the pathophysiology of tardive dyskinesia." International Journal of Research in Medical Sciences 11, no. 10 (2023): 3925–30. http://dx.doi.org/10.18203/2320-6012.ijrms20233065.

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Tardive dyskinesia (TD) is a neurological syndrome characterized by involuntary, repetitive, and unusual movements that primarily impact the orofacial region while also extending to other body parts, encompassing chorea, dystonia, tics, buccolingual stereotypy, and akathisia. This condition stems from iatrogenic factors, particularly the chronic administration of medications that obstruct dopamine receptors. Predominantly implicated are antipsychotic drugs, utilized primarily for schizophrenia and bipolar disorder treatment. These drugs modulate dopamine levels, yet prolonged usage can induce

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MISSALE, CRISTINA, S. RUSSEL NASH, SUSAN W. ROBINSON, MOHAMED JABER, and MARC G. CARON. "Dopamine Receptors: From Structure to Function." Physiological Reviews 78, no. 1 (1998): 189–225. http://dx.doi.org/10.1152/physrev.1998.78.1.189.

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Missale, Cristina, S. Russel Nash, Susan W. Robinson, Mohamed Jaber, and Marc G. Caron. Dopamine Receptors: From Structure to Function. Physiol. Rev. 78: 189–225, 1998. — The diverse physiological actions of dopamine are mediated by at least five distinct G protein-coupled receptor subtypes. Two D1-like receptor subtypes (D1 and D5) couple to the G protein Gs and activate adenylyl cyclase. The other receptor subtypes belong to the D2-like subfamily (D2 , D3 , and D4) and are prototypic of G protein-coupled receptors that inhibit adenylyl cyclase and activate K+ channels. The genes for the D1 a

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Helms, My N., Xi-Juan Chen, Semra Ramosevac, Douglas C. Eaton, and Lucky Jain. "Dopamine regulation of amiloride-sensitive sodium channels in lung cells." American Journal of Physiology-Lung Cellular and Molecular Physiology 290, no. 4 (2006): L710—L722. http://dx.doi.org/10.1152/ajplung.00486.2004.

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Dopamine increases lung fluid clearance. This is partly due to activation of basolateral Na-K-ATPase. However, activation of Na-K-ATPase by itself is unlikely to produce large changes in transepithelial transport. Therefore, we examined apical and basolateral dopamine's effect on apical, highly selective sodium channels [epithelial sodium channels (ENaC)] in monolayers of an alveolar type 2 cell line (L2). Dopamine increased channel open probability ( Po) without changing the unitary current. The D1 receptor blocker SCH-23390 blocked the dopamine effect, but the D2 receptor blocker sulpiride d

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Cheng, L., P. Precht, D. Frank, and C. T. Liang. "Dopamine stimulation of cAMP production in cultured opossum kidney cells." American Journal of Physiology-Renal Physiology 258, no. 4 (1990): F877—F882. http://dx.doi.org/10.1152/ajprenal.1990.258.4.f877.

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Dopamine receptors have been identified in many tissues including the kidney. To establish an in vitro system as a model for dopamine action, we studied the effect of dopamine (DA) receptor agonists and antagonists on adenosine 3',5'-cyclic monophosphate (cAMP) formation in opossum kidney (OK) cells. The stimulation of cAMP production in these cells by dopamine was dose dependent, and markedly higher levels were observed in the presence of dopamine plus a phosphodiesterase inhibitor, 3-isobutyl-1-methylxanthine. Half-maximal stimulation was found with 1.15 +/- 0.22 microM dopamine. A DA1-recep

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Ramanathan, Sankari, Tatiana Tkatch, Jeremy F. Atherton, Charles J. Wilson, and Mark D. Bevan. "D2-Like Dopamine Receptors Modulate SKCa Channel Function in Subthalamic Nucleus Neurons Through Inhibition of Cav2.2 Channels." Journal of Neurophysiology 99, no. 2 (2008): 442–59. http://dx.doi.org/10.1152/jn.00998.2007.

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The activity patterns of subthalamic nucleus (STN) neurons are intimately related to motor function/dysfunction and modulated directly by dopaminergic neurons that degenerate in Parkinson's disease (PD). To understand how dopamine and dopamine depletion influence the activity of the STN, the functions/signaling pathways/substrates of D2-like dopamine receptors were studied using patch-clamp recording. In rat brain slices, D2-like dopamine receptor activation depolarized STN neurons, increased the frequency/irregularity of their autonomous activity, and linearized/enhanced their firing in respo

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Livingstone, C. D., P. G. Strange, and L. H. Naylor. "Molecular modelling of D2-like dopamine receptors." Biochemical Journal 287, no. 1 (1992): 277–82. http://dx.doi.org/10.1042/bj2870277.

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Three-dimensional computer models of the rat D2, D3 and D4 dopamine receptor subtypes have been constructed based on the diffraction co-ordinates for bacteriorhodopsin, another membrane-bound protein containing seven transmembrane domains presumed to be arranged in a similar spatial orientation. Models were assembled by aligning the putative transmembrane domains of the dopamine receptors with those of bacteriorhodopsin using sequence similarities, and then superimposing these modelled alpha-helices on to the bacteriorhodopsin-derived co-ordinates. These models explore the potential hydrogen b

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Kawahata, Ichiro, David I. Finkelstein, and Kohji Fukunaga. "Dopamine D1–D5 Receptors in Brain Nuclei: Implications for Health and Disease." Receptors 3, no. 2 (2024): 155–81. http://dx.doi.org/10.3390/receptors3020009.

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Understanding the intricate role of dopamine D1–D5 receptors is pivotal in addressing the challenges posed by the aging global population, as well as by social stress and advancing therapeutic interventions. Central to diverse brain functions such as movement, cognition, motivation, and reward, dopamine receptors are ubiquitously distributed across various brain nuclei. This comprehensive review explores the nuanced functions of each dopamine receptor, D1, D2, D3, D4, and D5, in distinct brain regions, elucidating the alterations witnessed in several neurological and psychiatric disorders. Fro

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Zeng, Chunyu, Ines Armando, Yingjin Luo, Gilbert M. Eisner, Robin A. Felder, and Pedro A. Jose. "Dysregulation of dopamine-dependent mechanisms as a determinant of hypertension: studies in dopamine receptor knockout mice." American Journal of Physiology-Heart and Circulatory Physiology 294, no. 2 (2008): H551—H569. http://dx.doi.org/10.1152/ajpheart.01036.2007.

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Dopamine plays an important role in the pathogenesis of hypertension by regulating epithelial sodium transport and by interacting with vasoactive hormones/humoral factors, such as aldosterone, angiotensin, catecholamines, endothelin, oxytocin, prolactin pro-opiomelancortin, reactive oxygen species, renin, and vasopressin. Dopamine receptors are classified into D1-like (D1 and D5) and D2-like (D2, D3, and D4) subtypes based on their structure and pharmacology. In recent years, mice deficient in one or more of the five dopamine receptor subtypes have been generated, leading to a better understan

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Lokhandwala, Mustafa F., and Sharath S. Hegde. "Cardiovascular Dopamine Receptors: Role of Renal Dopamine and Dopamine Receptors in Sodium Excretion." Pharmacology & Toxicology 66, no. 4 (1990): 237–43. http://dx.doi.org/10.1111/j.1600-0773.1990.tb00741.x.

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Vásquez, C., R. Navarro-Polanco, G. Hernández, et al. "Cannabinoids and Dopamine Receptors' Action on Calcium Current in Rat Neurons." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 32, no. 4 (2005): 529–37. http://dx.doi.org/10.1017/s031716710000456x.

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ABSTRACT:Objective:To study the effects of cannabinoid, glutamate, and dopamine agonists and antagonists on the calcium current in rat sympathetic neurons.Methods:Calcium current was recorded using the whole-cell variant of the patch-clamp technique. After expression in neuronal membranes of the cannabinoid CB1, glutamate mGluR2, or dopamine D1 receptor (by microinjection of the relevant receptor's cDNA into the neuron's nucleus) agonists' and antagonists' effects were observed.Results:Applications of agonists of the expressed receptor (0.1-10 µM) decreased the calcium current. The calcium cur

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Barbanti, P., G. Fabbrini, A. Ricci, et al. "Migraine Patients Show an Increased Density of Dopamine D3 and D4 Receptors on Lymphocytes." Cephalalgia 20, no. 1 (2000): 15–19. http://dx.doi.org/10.1046/j.1468-2982.2000.00001.x.

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Recent studies have revealed peculiar functional and genetic features of dopamine receptors in migraine. As peripheral blood lymphocytes (PBL) may represent a tool for peripheral detection of neuroreceptors, we compared the expression of dopamine D3 (DRD3) and D4 (DRD4) receptors on PBL in migraine patients and in healthy controls using radioligand binding assay techniques in the presence of antidopamine D2-like receptor antibodies. The dopamine D2-like receptor agonist [3H]7-OH-DPAT was used as a radioligand. An increased density of both DRD3 ( P = 0.0006) and DRD4 ( P = 0.002) on PBL was obs

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Garcia-Garrote, Maria, Juan A. Parga, Pablo J. Labandeira, Jose Luis Labandeira-Garcia, and Jannette Rodriguez-Pallares. "Dopamine Regulates Adult Neurogenesis in the Ventricular-Subventricular Zone via Dopamine D3 Angiotensin Type 2 Receptor Interactions." Stem Cells 39, no. 12 (2021): 1778–94. http://dx.doi.org/10.1002/stem.3457.

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Abstract Adult neurogenesis is a dynamic and highly regulated process, and different studies suggest that dopamine modulates ventricular-subventricular zone (V-SVZ) neurogenesis. However, the specific role of dopamine and the mechanisms/factors underlying its effects on physiological and pathological conditions such as Parkinson's disease (PD) are not fully understood. Recent studies have described counter-regulatory interactions between renin-angiotensin system (RAS) and dopamine in peripheral tissues and in the nigrostriatal system. We have previously demonstrated that angiotensin receptors

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Tomassoni, Daniele, Enea Traini, Manuele Mancini, Vincenzo Bramanti, Syed Sarosh Mahdi, and Francesco Amenta. "Dopamine, vesicular transporters, and dopamine receptor expression in rat major salivary glands." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 309, no. 5 (2015): R585—R593. http://dx.doi.org/10.1152/ajpregu.00455.2014.

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The localization of dopamine stores and the expression and localization of dopamine (DAT) and vesicular monoamine transporters (VMAT) type-1 and -2 and of dopamine D1-like and D2-like receptor subtypes were investigated in rat submandibular, sublingual, and parotid salivary glands by HPLC with electrochemical detection, as well as immunochemical and immunohistochemical techniques. Male Wistar rats of 2 mo of age were used. The highest dopamine levels were measured in the parotid gland, followed by the submandibular and sublingual glands. Western blot analysis revealed DAT, VMAT-1, VMAT-2, and

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Shaikh, Sanober, Andrew Makoff, David Collier, and Robert Kerwin. "Dopamine D4 Receptors." CNS Drugs 8, no. 1 (1997): 1–11. http://dx.doi.org/10.2165/00023210-199708010-00001.

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Levant, Beth, Zao Dung Ling, and Paul M. Carvey. "Dopamine D3 Receptors." CNS Drugs 12, no. 5 (1999): 391–402. http://dx.doi.org/10.2165/00023210-199912050-00006.

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Kohli, Jai D. "Peripheral Dopamine Receptors." American Journal of Hypertension 3, no. 6_Pt_2 (1990): 25S—28S. http://dx.doi.org/10.1093/ajh/3.6.25s.

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De Keyser, J., and G. Ebinger. "Neostriatal dopamine receptors." Trends in Neurosciences 13, no. 8 (1990): 324. http://dx.doi.org/10.1016/0166-2236(90)90138-z.

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Gerfen, Charles R., and Kristen A. Keefe. "Neostriatal dopamine receptors." Trends in Neurosciences 17, no. 1 (1994): 2–3. http://dx.doi.org/10.1016/0166-2236(94)90022-1.

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Bloch, Bertrand, and Catherine Le Moine. "Neostriatal dopamine receptors." Trends in Neurosciences 17, no. 1 (1994): 3–4. http://dx.doi.org/10.1016/0166-2236(94)90023-x.

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Helmeste, Daiga M., and Siu Wa Tang. "Dopamine D4 Receptors." Japanese Journal of Pharmacology 82, no. 1 (2000): 1–14. http://dx.doi.org/10.1254/jjp.82.1.

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Woodruff, G. N. "Dwindling dopamine receptors." Trends in Pharmacological Sciences 7 (January 1986): 252–53. http://dx.doi.org/10.1016/0165-6147(86)90338-x.

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Kebabian, John W. "Multiple Dopamine Receptors." Journal of Pharmaceutical Sciences 74, no. 8 (1985): 910–11. http://dx.doi.org/10.1002/jps.2600740842.

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Ford, Christopher P., Michael J. Beckstead, and John T. Williams. "Kappa Opioid Inhibition of Somatodendritic Dopamine Inhibitory Postsynaptic Currents." Journal of Neurophysiology 97, no. 1 (2007): 883–91. http://dx.doi.org/10.1152/jn.00963.2006.

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In the midbrain, dopamine neurons can release dopamine somatodendritically. This results in an inhibitory postsynaptic current (IPSC) within adjacent dopamine cells that occurs by the activation of inhibitory D2 autoreceptors. Kappa, but not mu/delta, opioid receptors inhibit this IPSC. The aim of the present study was to determine the mechanism by which κ-opioid receptors inhibit the dopamine IPSC. In both the ventral tegmental area (VTA) and substantia nigra compacta (SNc) the κ-receptor agonist U69593 inhibited the IPSC, but not the current induced by the exogenous iontophoretic application

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Ferone, Diego, Federico Gatto, Marica Arvigo, et al. "The clinical–molecular interface of somatostatin, dopamine and their receptors in pituitary pathophysiology." Journal of Molecular Endocrinology 42, no. 5 (2009): 361–70. http://dx.doi.org/10.1677/jme-08-0162.

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The role of somatostatin and dopamine receptors as molecular targets for the treatment of patients with pituitary adenomas is well established. Indeed, dopamine and somatostatin receptor agonists are considered milestones for the medical therapy of these tumours. However, in recent years, the knowledge of the expression of subtypes of somatostatin and dopamine receptors in pituitary adenomas, as well as of the coexpression of both types of receptors in tumour cells, has increased considerably. Moreover, recent insights suggest a functional interface of dopamine and somatostatin receptors, when

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Wong, Franklin C., John Boja, Beng Ho, Michael J. Kuhar, and Dean F. Wong. "Affinity Labeling of Membrane Receptors Using Tissue-Penetrating Radiations." BioMed Research International 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/503095.

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Photoaffinity labeling, a usefulin vivobiochemical tool, is limited when appliedin vivobecause of the poor tissue penetration by ultraviolet (UV) photons. This study investigates affinity labeling using tissue-penetrating radiation to overcome the tissue attenuation and irreversibly label membrane receptor proteins. Using X-ray (115 kVp) at low doses (<50 cGy or Rad), specific and irreversible binding was found on striatal dopamine transporters with 3 photoaffinity ligands for dopamine transporters, to different extents. Upon X-ray exposure (115 kVp), RTI-38 and RTI-78 ligands showed irreve

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