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Dissertations / Theses on the topic 'Dopaminergic neurons'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

DE, SANCTIS Claudia. "MicroRNAs profiling in Dopaminergic neurons." Doctoral thesis, Università degli studi del Molise, 2018. http://hdl.handle.net/11695/83499.

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Lo sviluppo dei neuroni dopaminergici mesencefalici (mDA) è un fenomeno complesso e non ancora pienamente compreso. Molti studi hanno focalizzato la loro attenzione sul ruolo svolto da diversi fattori di trascrizione specifici e ben noti. L'obiettivo della mia tesi di dottorato è focalizzato su una classe relativamente nuova di regolatori post-trascrizionali denominati microRNA (miRNAs), in grado di regolare l'espressione genica legando le sequenze parzialmente complementari nelle regioni 3' non tradotte (UTR) degli mRNAs target. Per studiare il ruolo svolto dai miRNAs durante la differenziaz

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2

Dommett, Eleanor Jane. "Sensory regulation of midbrain dopaminergic neurons." Thesis, University of Sheffield, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425614.

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3

Decker, Amanda R. "TRPM7 function in zebrafish dopaminergic neurons." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/5927.

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TRPM7 (Transient Receptor Potential Melastatin-like 7) is an ion channel necessary for the proper development of many cell types. Insight into the precise role of the channel in different cells has been hampered by the lethality of knocking out the gene in model organisms such as the mouse. Here I examine a zebrafish that has a loss-of-function mutation in the gene encoding Trpm7. First, I show that trpm7 is important for the function of developing dopaminergic neurons in the zebrafish. Second, I examine the interaction between trpm7 and the related gene vmat2 in order to develop a cellular me

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4

Love, Rebecca Margaret. "Improving the survival of embryonic dopaminergic neurons." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343277.

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5

Adams, Van L. "Seasonal plasticity of A15 dopaminergic neurons in the ewe." Morgantown, W. Va. : [West Virginia University Libraries], 2001. http://etd.wvu.edu/templates/showETD.cfm?recnum=2096.

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Thesis (M.S.)--West Virginia University, 2001.<br>Title from document title page. Document formatted into pages; contains vii, 79 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 70-78).

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6

Lak, Armin. "Encoding of economic value by midbrain dopamine neurons." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648342.

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7

Zietlow, Rike. "Factors affecting the survival of embryonic dopaminergic neurones after transplantation." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624313.

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8

Pöltl, Dominik [Verfasser]. "Degeneration mechanisms in human dopaminergic neurons / Dominik Pöltl." Konstanz : Bibliothek der Universität Konstanz, 2012. http://d-nb.info/1025226135/34.

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9

Moubarak, Estelle. "Constraints imposed by morphological and biophysical properties of axon and dendrites on the electrical behaviour of rat substantia nigra pars compacta dopaminergic neurons." Thesis, Aix-Marseille, 2018. http://www.theses.fr/2018AIXM0746.

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L’activité électrique des neurones est déterminée par des interactions complexes entre leurs propriétés morphologiques et biophysiques. Les neurones dopaminergiques (DA) de la substance noire compacte (SNc) présentent une caractéristique morphologique peu commune parmi les neurones de mammifères: leur axone émerge fréquemment d’une dendrite à une distance très variable du soma. Malgré cette importante variabilité dans la localisation de l’axone, peu d’articles ont étudié un lien potentiel entre morphologie neuronale et activité électrique dans ces cellules. Dans un premier article, nous avons

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10

Sousa, Kyle Matthew. "Nuclear receptor and Wnt function in developing dopaminergic neurons /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-105-0/.

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11

Zambon, Federico. "Studying α-Synuclein pathology using iPSC-derived dopaminergic neurons". Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:2856dcf3-0f38-4a37-9242-8c685d1c2c3a.

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Parkinson's disease (PD) is characterised by the loss of dopaminergic neurons in the Substantia Nigra pars compacta in the midbrain and the presence of intracellular aggregates, known as Lewy bodies (LBs), in the surviving neurons. The aetiology of PD is unknown but a causative role for α-Synuclein (SNCA) has been proposed. Although the function of αSyn is not well understood, a number of pathological mechanisms associated with αSyn toxicity have been proposed. In this study, nine induced pluripotent stem cells (iPSCs) lines from healthy individuals and PD patients carrying t

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12

Gavinio, Roberto. "PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates." Kyoto University, 2013. http://hdl.handle.net/2433/180338.

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13

Hayashi, Hideki. "Meningeal cells induce dopaminergic neurons from embryonic stem cells." Kyoto University, 2008. http://hdl.handle.net/2433/124217.

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14

Vazin, Tandis. "Generation of Dopaminergic Neurons from Human Embryonic Stem Cells." Doctoral thesis, Stockholm : Bioteknologi, Kungliga Tekniska högskolan, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-9591.

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15

Yamazoe, Hironori. "Encapsulation of dopaminergic neurons derived from embryonic stem cells." 京都大学 (Kyoto University), 2006. http://hdl.handle.net/2433/143987.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(工学)<br>甲第12290号<br>工博第2619号<br>新制||工||1369(附属図書館)<br>24126<br>UT51-2006-J283<br>京都大学大学院工学研究科高分子化学専攻<br>(主査)教授岩田博夫, 教授田畑泰彦, 教授木村俊作<br>学位規則第4条第1項該当

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16

Contrafatto, Donatella. "Asymmetry of nigral dopaminergic neurons' depletion in parkinson's disease." Thesis, Universita' degli Studi di Catania, 2011. http://hdl.handle.net/10761/92.

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Parkinson's disease (PD) is a neurological disorder characterized by the lateralization of motor manifestations, that is still evident late in the course of disease, corresponding to the unilateral predominance of the nigrostriatal degenerative process. The diagnosis is essentially clinical, supported by the evidence of a good clinical dopaminergic response. However the diagnosis is sometimes difficult also in a movement disorders' specialist setting, especially with vascular parkinsonism (VP) due to the overlap in clinical presentation and the lack of specificity at neuroimaging. We studied

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17

Grison, Alice. "Unexpected expression of Olfactory Receptors in mesencephalic dopaminergic neurons." Doctoral thesis, SISSA, 2012. http://hdl.handle.net/20.500.11767/4716.

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Parkinson’s disease is the second most common neurodegenerative disease after Alzheimer’s disease. One of the most evident pathological hallmarks in PD is the selective loss of mesencephalic dopaminergic (mDA) neurons with the consequent decrease of dopamine in the brain. mDA neurons present two main groups of projecting cells: the A9 neurons of the Substantia Nigra (SN) and the A10 cells of the Ventral Tegmental Area (VTA). A9 neurons controls the nigrostriatal pathway and are involved in regulation of voluntary movements and postural reflexes. Their selective degeneration leads to Parkinson

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18

Brothwell, Shona Lindsay Crawford. "Properties of NMDA receptors in Substantia nigra pars compacta dopaminergic neurones." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612352.

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19

Castelo-Branco, Gonçalo de Sá e. Sousa de. "Wnt signalling in the development of ventral midbrain dopaminergic neurons /." Stockholm, 2004. http://diss.kib.ki.se/2005/91-7140-176-8/.

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20

Davies, Nicholas Oliver. "Function, regeneration and neuroprotection of dopaminergic neurons in the zebrafish." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25858.

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The zebrafish has an amazing capacity for regeneration which includes regeneration of neurons within the central nervous system (CNS) both during development and into adulthood. This attribute makes the zebrafish a valuable tool in the study of regeneration. In this thesis, the research focussed on the regeneration of a specific type of cell in the CNS, dopaminergic (DA) neurons. The DA system of the zebrafish is believed to be evolutionarily conserved with comparable DA populations found in the brain of mammals. Dissimilar to mammals, however, the zebrafish is capable of regenerating various

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21

Gonzalez, Robert Tomas. "Neurotrophic Effects of VEGF-B on Dopaminergic Neurons In-Vitro." Thesis, The University of Arizona, 2010. http://hdl.handle.net/10150/156914.

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Vascular endothelial growth factor B (VEGF-B) has shown potential for therapeutic implementation as a neuroprotective factor in the treatment of neurodegenerative disorders, including Parkinson's disease (PD). The goals of this study were two-fold: (i) to determine the neurotrophic effect of both known VEGF-B isoforms on primary neurite length of dopaminergic (DA) neurons in culture, and (ii) to compare this effect against the neurotrophic effects of other growth factors known to increase neurite outgrowth in culture. Glial-derived neurotrophic factor (GDNF), vascular endothelial growth factor

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22

Simone, Roberto. "New approaches to unveil the Transcriptional landscape of dopaminergic neurons." Doctoral thesis, SISSA, 2008. http://hdl.handle.net/20.500.11767/4676.

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Recent advances in studying the mammalian transcriptome arised new questions about how genes are organized and what is the function of noncoding RNAs. Furthermore, the discovery of large amounts of polyA- transcripts and antisense transcription proved that a portion of the transcriptome has still to be characterized. The complex anatomo-functional organization of the brain has prevented a comprehensive analysis of the transcriptional landscape of this tissue. New techniques must be developed to approach neuronal heterogeneity. In this study we combined Laser Capture Microdissection (LCM) and

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23

Tripanichkul, Wanida 1962. "Associations between glia and sprouting of dopaminergic axons." Monash University, Dept. of Medicine, 2002. http://arrow.monash.edu.au/hdl/1959.1/7630.

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24

Daniel, James St Vincent Clinical School UNSW. "Studies of neurotransmitter release mechanisms in dopamine neurons." Awarded by:University of New South Wales. St. Vincent Clinical School, 2007. http://handle.unsw.edu.au/1959.4/31934.

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Medications that treat diseases such as Parkinson???s disease work by regulating dopamine transmission at synapses. Surprisingly, little is known about the mechanisms regulating dopamine release at synapses. In this thesis, we study mechanisms that regulate vesicle recycling in axons and dendrites of dopamine neurons. Key questions we addressed were: (1) Are vesicles in axons and dendrites associated with the same regulatory proteins, and thus by implication the same regulatory mechanisms, as in excitatory neurons; (2) Do vesicles undergo recycling, and (3) if so, are they characterised by a d

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25

Schwartz, Catherine. "Derivation, enrichment and characterization of dopaminergic neurons from pluripotent stem cells /." Stockholm, 2010. http://diss.kib.ki.se/2010/978-91-7409-867-9/.

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26

Thuret, Sandrine. "Identification and characterization of genes expressed by the midbrain dopaminergic neurons." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=964263033.

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27

Karuppagounder, Senthilkumar S. Dhanasekaran Muralikrishnan Suppiramaniam Vishnu. "Environmental toxins and dopaminergic neurotoxicity novel neuroprotective strategies /." Auburn, Ala, 2009. http://hdl.handle.net/10415/1883.

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28

Edman, Linda C. "Chemokines and their role in dopaminergic development." Stockholm : Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2009. http://diss.kib.ki.se/2009/978-91-7409-688-0/.

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29

Bogusz, Adrienne L. "Afferent regulation of A15 dopamine neurons in the ewe." Morgantown, W. Va. : [West Virginia University Libraries], 2006. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=4928.

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Thesis (M.S.)--West Virginia University, 2006.<br>Title from document title page. Document formatted into pages; contains vi, 86 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 75-85).

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30

GAMBARDELLA, Cristina. "Caratterizzazione della corrente h in neuroni dopaminergici della substantia nigra pars compacta." Doctoral thesis, Università degli studi di Ferrara, 2011. http://hdl.handle.net/11392/2388763.

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1. Introduzione I neuroni dopaminergici (DA) della substantia nigra pars compacta (SNc) sono tra i più studiati nel sistema nervoso centrale per la loro implicazione nella malattia del Parkinson. Essi presentano un ampio corredo di correnti voltaggio-dipendenti, tra le quali emerge una tipica corrente attivata da iperpolarizzazione, la Ih. Diversamente dalla maggior parte delle cellule nervose, i neuroni dopaminergici della SNc presentano una attività spontanea regolare dopo isolamento o riduzione degli input sinaptici, e non è, quindi, sorprendente che numerosi lavori abbiano indagato il ruo

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31

Dugan, James P. "Midbrain dopaminergic axons are guided longitudinally by slit/robo signaling." abstract and full text PDF (free order & download UNR users only), 2008. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:1456486.

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32

Doherty, Michael 1964. "Effects of repeated stress on mesocorticolimbic dopaminergic neurons : in vivo voltammetric studies." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=57013.

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The effects of repeated, once daily exposure to either tail pinch or restraint stress on extracellular DA levels in nucleus accumbens (NAcc), prefrontal cortex (PFC), and striatum (STR) was monitored in conscious rats using high-speed chronoamperometry, an electrochemical detection technique. The first exposure to either stress reliably and consistently elevated DA levels in the extracellular space of NAcc, PFC, and STR; the increases observed in PFC were of a greater magnitude than those observed in NAcc and STR. These data are consistent with those of previous studies suggesting a higher res

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33

Brown, Sarah. "Adult generation of dopaminergic neurons in a genetic model of Parkinson's disease." Thesis, University of Sheffield, 2018. http://etheses.whiterose.ac.uk/21269/.

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34

Senior, Steven L. "Functional analysis of alpha-synuclein." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670161.

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35

Bergstrom, Brian P. Garris Paul A. "Compensatory adaptation in preclinical Parkinson's disease." Normal, Ill. Illinois State University, 2001. http://wwwlib.umi.com/cr/ilstu/fullcit?p3064477.

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Thesis (Ph. D.)--Illinois State University, 2001.<br>Title from title page screen, viewed April 13, 2006. Dissertation Committee: Paul A. Garris (chair), John E. Baur, Hou T. Cheung, Maarten E.A. Reith, David L. Williams. Includes bibliographical references (leaves 170-186) and abstract. Also available in print.

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36

Godoy, Rafael Soares. "Chemogenetic Ablation of Dopaminergic Neurons in the Brain of Larval and Adult Zebrafish (Danio Rerio): Phenotypes and Regenerative Ability." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32541.

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Dopamine exerts an important role in the regulation of motor activity in humans. During the progression of Parkinson’s disease, patients are faced with the progressive neurodegeneration of nigro-striatal dopamine neurons resulting in an array of pathological symptoms characteristic of the disease. Current treatment relies on targeting symptomatic aspects of the disease but currently Parkinson’s disease is incurable. Targeting the regeneration of DA neurons in PD patients could offer an alternative therapeutic approach that could stall and perhaps even revert the progression of the disease and

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37

Vinciati, Federica. "Electrophysiological properties of striatal neurons in the dopamine-intact and Parkinsonian brain." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:e4e84e31-bc00-43b2-a930-dc7fa4143b1a.

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The striatum is the major input structure of the basal ganglia, and is composed of two major populations of spiny projection neurons (MSNs), which give rise to the socalled direct and indirect pathways, and several types of interneuron. Dopaminergic inputs to striatum are critical for its proper function. Indeed, loss of dopaminergic neurons in Parkinsonism leads to motor disturbances, grossly disturbs striatal activity, and is associated with the emergence of excessively-synchronized network oscillations at beta frequencies (15-30 Hz) throughout the basal ganglia. How the distinct structural,

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38

Tripathi, Prem Prakash. "Developmental basis of seizure susceptibility: a focus on dopaminergic and serotonergic systems." Doctoral thesis, Scuola Normale Superiore, 2010. http://hdl.handle.net/11384/85977.

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39

Brown, Matthew Thomas Clifford. "Electrophysiological Neurochemical and morphological characterisation of the dopaminergic neurons in the substantia Nigra." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.504319.

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40

Chabrat, Audrey, and Audrey Chabrat. "Role of Lmx1a and Lmx1b transcription factors in post-mitotic midbrain dopaminergic neurons." Doctoral thesis, Université Laval, 2016. http://hdl.handle.net/20.500.11794/28203.

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Lmx1a et Lmx1b sont des facteurs de transcription connus pour leur rôle au cours du développement des neurones dopaminergiques du mésencéphale (mDA). Ils ont été montrés comme essentiels à chacune des étapes de différentiation des progéniteurs en neurones dopaminergiques matures. Des études récentes ont également mis en évidence l'importance de ces deux facteurs de transcription dans les neurones dopaminergiques chez l'adulte. Lmx1a/b sont impliqués dans la régulation de gènes mitochondriaux ainsi que dans l'autophagie. Cependant, jusqu'à présent, rien n'est connu sur le rôle de Lmx1a/b dans l

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41

Wiemerslage, Lyle N. "Neuroprotection of Dopaminergic Neurons and their Subcellular Structures from Parkinson's Disease-like Treatment." Ohio University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1395669814.

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42

Takeuchi, Hiroki. "Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone-induced Parkinson's disease models." Kyoto University, 2009. http://hdl.handle.net/2433/124255.

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43

Bertram, Craig. "Cortical and subcortical somatosensory regulation of dopaminergic neurons : role of the superior colliculus." Thesis, University of Sheffield, 2011. http://etheses.whiterose.ac.uk/2262/.

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Dopaminergic (DA) neurons exhibit a short-latency, phasic response to unexpected biologically salient stimuli, including rewards. Despite extensive research on this DA signal, very little is known about the sources of sensory information reaching DA neurons. Previous research has identified the superior colliculus (SC) as the primary, if not exclusive route of short latency visual input to DA neurons. However, more recent research has suggested that the phasic DA response comprises two components; a short latency (50-110 ms), stimulus insensitive component, and a longer latency component (110-

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44

Tang, Sze-Man Clara. "The effects of cholinergic and dopaminergic neurons on hippocampal learning and memory processes." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/270864.

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Dysfunction of cholinergic and dopaminergic systems has been implicated in memory function de cits that are core pathology and associated features of several neurological disorders. However, in order to develop more effective treatments, it is crucial to better understand how different aspects of learning and memory are modulated by these neuromodulatory systems. Using optogenetic stimulation or silencing, this thesis aims to investigate the effects of cholinergic and dopaminergic modulation on various hippocamal learning and memory processes. To understand how these neuromodulatory systems mo

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Booth, Heather D. E. "Modelling and analysis of LRRK2 mutations in iPSC-derived dopaminergic neurons and astrocytes." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:d85d164e-e9d4-4911-8aa0-831d4519a5a2.

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Parkinson's disease (PD) is a common neurodegenerative disorder, characterised by preferential loss of ventral midbrain dopaminergic (vmDA) neurons in the substantia nigra pars compacta (SNc). The majority of PD cases have unknown aetiology; however, between 5-10% arise due to known genetic mutations, the most common of which are found in the LRRK2 gene. LRRK2 is expressed in neurons and glia in the human brain; therefore, cell-autonomous and/or non-cell autonomous effects may participate in LRRK2-mutation-mediated degeneration of vmDA neurons. This study set out to understand the effects of L

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46

Marcuzzi, Federica. "Erythropoietin Receptor and Hemoglobin, two commonly blood – associated proteins, in mesencephalic dopaminergic neurons." Doctoral thesis, SISSA, 2012. http://hdl.handle.net/20.500.11767/4720.

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Dopaminergic neurons (DA) are an anatomically and functionally heterogeneous group of cells involved in a wide range of neuronal network activities and behaviour. Among them, mesencephalic dopaminergic neurons (mDA) are the major source of dopamine in the brain. They present two main groups of projecting cells: the A9 neurons of the Substantia Nigra (SN) and the A10 cells of the Ventral Tegmental Area (VTA). A9 neurons form the nigrostriatal pathway and are involved in regulating voluntary movements and postural reflexes. Their selective degeneration leads to Parkinson’s disease (PD) and the l

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47

Sánchez, Danés Adriana 1984. "Generation of human dopaminergic neurons from induced pluripotent stem cells to model Parkinson's disease." Doctoral thesis, Universitat Pompeu Fabra, 2012. http://hdl.handle.net/10803/96912.

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Parkinson’s disease (PD) is an incurable, chronically progressive neurodegenerative disease leading to premature invalidity and death. The locomotor disability of PD patients is mainly rooted in the gradual and insidious degeneration of dopaminergic neurons (DA) projecting from the midbrain substantia nigra (SN) to the basal ganglia striatum, a pathological process highlighted microscopically by the formation of insoluble cytosolic protein aggregates, known as Lewy bodies and Lewy neurites. The pathogenic mechanisms leading to PD remain poorly understood, arguably owing to the lack of suitable

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48

Alberi, Lavinia. "Engrailed genes are cell autonomously required for the survival of the mesencephalic dopaminergic neurons." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=970524617.

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49

Venables, Maddie Jolyane. "Characterization of Nestin Proteins in the Goldfish: Implications for Regeneration of Adult Dopaminergic Neurons." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34191.

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Nestin is a type VI intermediate filament protein that marks proliferative cells in the central and peripheral nervous system of vertebrates during development and adulthood. Nestin is not only expressed in progenitor cells of neuronal tissues but is also present in muscle, heart, lung, pancreas and skin follicle tissues. The goal of this thesis is to investigate and characterize the nestin protein in goldfish and relate nestin expression to neuroregeneration and brain plasticity events in the adult goldfish forebrain. Currently little is known about nestin function and regulation in vertebrat

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50

Alireza, Tamara. "Investigating the effects of the microglial inflammatory response on iron metabolism in dopaminergic neurons." Thesis, Imperial College London, 2017. http://hdl.handle.net/10044/1/60641.

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Parkinson’s disease (PD) is a chronic progressive neurodegenerative disorder characterised by selective loss of dopaminergic neurons in the substantia nigra. Drugs are the principal method of symptom treatment, yet remain unable to reverse underlying neurodegeneration. As PD prevalence increases with aging populations, greater emphasis falls on understanding pathogenesis to establish an effective neuroprotective strategy. Current research identifies iron accretion as a potential pathogenic factor. Iron is crucial for healthy cellular physiology, however, dysregulation can be highly neurotoxic.

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