Academic literature on the topic 'Dp103'

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Journal articles on the topic "Dp103"

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Singh, Shikha Satendra. "Characterization of a novel regulator of AKT/mTOR signaling in gastric cancer." Journal of Clinical Oncology 34, no. 4_suppl (2016): 68. http://dx.doi.org/10.1200/jco.2016.34.4_suppl.68.

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68 Background: Gastric cancer (GC) is a leading cause of cancer-related death with poor prognosis and “one-size fits all approach”. Dysregulation of PI3K/Akt/mTOR pathway is a common event in GC with PIK3CAmutations reported to correlate with poor prognosis. With prognosis far from satisfactory, we aimed to identify novel surrogate biomarkers. We hypothesize the role of DP103, a DEAD-box RNA helicase, as a novel surrogate biomarker for GC by regulating the PI3K/Akt/mTOR pathway. Additionally, we shed light on high DP103 GC cells responding to Akt/mTOR dual inhibitor treatment, indicating its p
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Mouillet, Jean-François, Xiaomei Yan, Qinglin Ou, et al. "DEAD-Box Protein-103 (DP103, Ddx20) Is Essential for Early Embryonic Development and Modulates Ovarian Morphology and Function." Endocrinology 149, no. 5 (2008): 2168–75. http://dx.doi.org/10.1210/en.2007-1237.

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The DEAD-box helicase DP103 (Ddx20, Gemin3) is a multifunctional protein that interacts with Epstein-Barr virus nuclear proteins (EBNA2/EBNA3) and is a part of the spliceosomal small nuclear ribonucleoproteins complex. DP103 also aggregates with the micro-RNA machinery complex. We have previously shown that DP103 interacts with the nuclear receptor steroidogenic factor-1 (SF-1, NR5A1), a key regulator of reproductive development, and represses its transcriptional activity. To further explore the physiological function of DP103, we disrupted the corresponding gene in mice. Homozygous Dp103-null
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Voss, Marc D., Annette Hille, Stephanie Barth, et al. "Functional Cooperation of Epstein-Barr Virus Nuclear Antigen 2 and the Survival Motor Neuron Protein in Transactivation of the Viral LMP1 Promoter." Journal of Virology 75, no. 23 (2001): 11781–90. http://dx.doi.org/10.1128/jvi.75.23.11781-11790.2001.

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ABSTRACT Epstein-Barr virus nuclear antigen 2 (EBNA2) is essential for viral transformation of B cells and transactivates cellular and viral target genes by binding RBPJκ tethered to cognate promoter elements. EBNA2 interacts with the DEAD-box protein DP103 (DDX20/Gemin3), which in turn is complexed to the survival motor neuron (SMN) protein. SMN is implicated in RNA processing, but a role in transcriptional regulation has also been suggested. Here, we show that DP103 and SMN are complexed in B cells and that SMN coactivates the viral LMP promoter in the presence of EBNA2 in reporter gene assa
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Yan, Xiaomei, Jean-François Mouillet, Qinglin Ou, and Yoel Sadovsky. "A Novel Domain within the DEAD-Box Protein DP103 Is Essential for Transcriptional Repression and Helicase Activity." Molecular and Cellular Biology 23, no. 1 (2003): 414–23. http://dx.doi.org/10.1128/mcb.23.1.414-423.2003.

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ABSTRACT Members of the DEAD-box family of helicases, distinguished by a core characteristic sequence of Asp-Glu-Ala-Asp, are expressed in a wide range of prokaryotes and eukaryotes and exhibit diverse cellular functions, including DNA transcription, recombination and repair, RNA processing, translation, and posttranslational regulation. Although ubiquitous, the function of most DEAD-box proteins is unknown. We and others have recently cloned DP103, which harbors conserved DEAD-box, helicase, and ATPase domains in its N terminus. DP103 (also termed Gemin3 and DDX20) interacts with SF-1, SMN, E
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Heba, G. Abd El-Aziz, S. El-Shaer Shereen, M. Abd El-Latif Doaa, Gomaa M., and M. Kamel Mahmoud. "Dp103 in Egyptian Patients with Breast Cancer: Prognosis to Lymph Node Metastasis." Journal of Cancer and Tumor International 5, no. 4 (2017): 1–10. https://doi.org/10.9734/JCTI/2017/35052.

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<strong>Background:</strong> Dp103 is a multifunctional protein which binds and unwinds RNA secondary structures, therefore plays a vital role in RNA metabolism from birth to death. <strong>Aims: </strong>The present study aimed to evaluate both serum levels and tissue expressions of Dp103 and explored their possible roles in lymph node metastasis within breast cancer Egyptian patients. <strong>Methodology:</strong> Sixty patients were enrolled in this study; they were subdivided into two groups. First group included forty females newly diagnosed as primary breast cancer their age ranged from
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Ou, Qinglin, Jean-François Mouillet, Xiaomei Yan, Christoph Dorn, Peter A. Crawford, and Yoel Sadovsky. "The DEAD Box Protein DP103 Is a Regulator of Steroidogenic Factor-1." Molecular Endocrinology 15, no. 1 (2001): 69–79. http://dx.doi.org/10.1210/mend.15.1.0580.

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Abstract The nuclear receptor steroidogenic factor-1 (SF-1) is essential for development of the gonads, adrenal gland, and the ventromedial hypothalamic nucleus. It also regulates the expression of pivotal steroidogenic enzymes and other important proteins in the reproductive system. We sought to elucidate the mechanisms that govern the transcriptional activity of SF-1. We demonstrate here that a previously uncharacterized domain, located C-terminal to the DNA binding domain of SF-1, exhibits transcriptional repression function. Point mutations in this domain markedly potentiate the transcript
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Lee, Martin B., Lioudmila A. Lebedeva, Miyuki Suzawa, Subhagya A. Wadekar, Marion Desclozeaux, and Holly A. Ingraham. "The DEAD-Box Protein DP103 (Ddx20 or Gemin-3) Represses Orphan Nuclear Receptor Activity via SUMO Modification." Molecular and Cellular Biology 25, no. 5 (2005): 1879–90. http://dx.doi.org/10.1128/mcb.25.5.1879-1890.2005.

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ABSTRACT Structural analysis of nuclear receptor subfamily V orphan nuclear receptors suggests that ligand-independent mechanisms must regulate this subclass of receptors. Here, we report that steroidogenic factor 1 (SF-1) and liver receptor homolog 1 are repressed via posttranslational SUMO modification at conserved lysines within the hinge domain. Indeed, mutating these lysines or adding the SUMO isopeptidase SENP1 dramatically increased both native and Gal4-chimera receptor activities. The mechanism by which SUMO conjugation attenuates SF-1 activity was found to be largely histone deacetyla
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Lee, Kangseok, Margareta D. Pisarska, Jeong-Jae Ko, et al. "Transcriptional factor FOXL2 interacts with DP103 and induces apoptosis." Biochemical and Biophysical Research Communications 336, no. 3 (2005): 876–81. http://dx.doi.org/10.1016/j.bbrc.2005.08.184.

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Shin, Eun Myoung, Motomi Osato, Alan Prem Kumar, and Vinay Tergaonkar. "RNA helicase DP103 and TAK1: a new connection in cancer." Molecular & Cellular Oncology 2, no. 3 (2015): e985911. http://dx.doi.org/10.4161/23723556.2014.985911.

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Shin, Eun Myoung, Hui Sin Hay, Moon Hee Lee, et al. "DEAD-box helicase DP103 defines metastatic potential of human breast cancers." Journal of Clinical Investigation 124, no. 9 (2014): 3807–24. http://dx.doi.org/10.1172/jci73451.

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Books on the topic "Dp103"

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Lost Civilisation?: The Contested Islamic Past in Spain and Portugal (Duckworth Debates in Archaeology). Duckworth Publishers, 2007.

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Spanish identity in the age of nations. Manchester University Press, 2011.

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Islamic Spain, 1250 to 1500. University of Chicago Press, 1992.

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Islamic Spain, 1250 to 1500. University of Chicago Press, 1990.

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Book chapters on the topic "Dp103"

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Younis, Wasim. "DP13 – Assembly Optimization." In Up and Running with Autodesk Inventor Simulation 2011. Elsevier, 2010. http://dx.doi.org/10.1016/b978-0-12-382102-7.10015-7.

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Younis, Wasim. "DP10 – Cyclic Symmetry Analysis." In Up and Running with Autodesk Inventor Simulation 2011. Elsevier, 2010. http://dx.doi.org/10.1016/b978-0-12-382102-7.10012-1.

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Mortensen, John J. "After Furno." In Improvising Fugue. Oxford University PressNew York, 2023. http://dx.doi.org/10.1093/oso/9780197645239.003.0004.

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Abstract This chapter lists and explains many additional bass motions in common use in the eighteenth century (beyond those taught in Furno). Motions include Fauxbourdon, 8-7-6, 10-9-8, Corelli Leapfrog, Romanesca, DP10, Perfidia, Monte Principale, Dolareti, Domirefa, Falling Thirds, Monte, Lamento, Valente Chromatic Ascent, Fenaroli Chromatic Ascent, Über-Lamento, and Martini. Each motion is explained in detail, followed by guided exercises at the keyboard.
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Conference papers on the topic "Dp103"

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Lai, Xianning, Tingting Wang, Tuan Zea Tan, et al. "Abstract A28: DEAD-box RNA helicase DP103 enhances YAP sumoylation for YAP-TEAD dependence and statin sensitivity in triple-negative breast cancer." In Abstracts: AACR Special Conference on the Hippo Pathway: Signaling, Cancer, and Beyond; May 8-11, 2019; San Diego, CA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1557-3125.hippo19-a28.

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Cai, W., JK Cheong, E. Edison та ін. "Abstract P4-08-03: DEAD-box RNA helicase DP103 as a novel regulator of Wnt/β-catenin signaling pathway and promotes cancer stem cell-like behavior in triple negative breast cancers". У Abstracts: Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium; December 8-12, 2015; San Antonio, TX. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.sabcs15-p4-08-03.

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