Relevant bibliographies by topics / Drug discovery; natural products; proteomics

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Drug discovery; natural products; proteomics'

Author: Grafiati
Published: 5 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "Drug discovery; natural products; proteomics"

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Huang, Huibin, and Jun He. "Proteomics in Natural Products: An Overview of Bioactive Compounds Research." Journal of Pharmaceutical and Biomedical Sciences 12, no. 02 (2022): 26–39. https://doi.org/10.5281/zenodo.7116089.

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Proteomics originated from 2-dimensional electrophoresis more than thirty years ago. Technological advances have made proteomics one of the most flourishing areas of modern biotechnology research. Proteomics mainly characterizes protein functions, protein–protein interactions, and protein modification in cells, tissues or animals. The integration of proteomic data helps to screen bioactive compounds, biomarkers of diseases, or signaling pathways in cells or the whole body. Natural products are valuable resources that contain a variety of bioactive compounds. However, the mechanisms of ac
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Wright, M. H., and S. A. Sieber. "Chemical proteomics approaches for identifying the cellular targets of natural products." Natural Product Reports 33, no. 5 (2016): 681–708. http://dx.doi.org/10.1039/c6np00001k.

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Piggott, Andrew, and Peter Karuso. "Quality not Quantity: The Role of Marine Natural Products in Drug Discovery and Reverse Chemical Proteomics." Marine Drugs 3, no. 2 (2005): 36–63. http://dx.doi.org/10.3390/md302036.

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Machado, António, Lizbeth Zamora-Mendoza, Frank Alexis, and José Miguel Álvarez-Suarez. "Use of Plant Extracts, Bee-Derived Products, and Probiotic-Related Applications to Fight Multidrug-Resistant Pathogens in the Post-Antibiotic Era." Future Pharmacology 3, no. 3 (2023): 535–67. http://dx.doi.org/10.3390/futurepharmacol3030034.

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The ‘post-antibiotic’ era is near according to the World Health Organization (WHO). It is well known, due to the work of the scientific community, that drugs (antibiotics, antifungals, and other antimicrobial agents) are continuously becoming less effective, and multidrug-resistant (MDR) pathogens are on the rise. This scenario raises concerns of an impending global infectious disease crisis, wherein a simple opportunistic infection could be deadly for humans. The war against MDR pathogens requires innovation and a multidisciplinary approach. The present study provides comprehensive coverage o
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Chele, Kekeletso H., Lizelle A. Piater, Justin J. J. van der van der Hooft, and Fidele Tugizimana. "Bridging Ethnobotanical Knowledge and Multi-Omics Approaches for Plant-Derived Natural Product Discovery." Metabolites 15, no. 6 (2025): 362. https://doi.org/10.3390/metabo15060362.

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For centuries, plant-derived natural products (NPs) have been fundamental to traditional medicine, providing essential therapeutic compounds. Ethnobotanical knowledge has historically guided NP discovery, leading to the identification of key pharmaceuticals such as aspirin, morphine, and artemisinin. However, conventional bioactivity-guided fractionation methods for NP isolation are labour-intensive and can result in the loss of bioactive properties due to the focus on a single compound. Advances in omics sciences—genomics, transcriptomics, proteomics, metabolomics, and phenomics—coupled with
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Satheeshkumar, Nanjappan, Narayanan Nisha, Nirmal Sonali, Jayabalan Nirmal, Gaurav K. Jain, and Vudataneni Spandana. "Analytical Profiling of Bioactive Constituents from Herbal Products, using Metabolomics - A Review." Natural Product Communications 7, no. 8 (2012): 1934578X1200700. http://dx.doi.org/10.1177/1934578x1200700837.

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Natural products have been the source of many active substances in drug discovery. There are several strategies/approaches in the field of biology, drug discovery, molecular and cell biology for identification of bioactive molecules. Metabolomics involves fewer complexities, is more precise and provides more relevant data compared with other techniques. This approach is based on the application of new technologies and provides real-world end points that complement and help in the interpretation of genomic and proteomic data in drug discovery. It has also been proven to be a valuable analytical
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Yingchutrakul, Yodying, Sucheewin Krobthong, Kiattawee Choowongkomon, et al. "Discovery of a Multifunctional Octapeptide from Lingzhi with Antioxidant and Tyrosinase Inhibitory Activity." Pharmaceuticals 15, no. 6 (2022): 684. http://dx.doi.org/10.3390/ph15060684.

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Ganoderma lucidum or Lingzhi is a fungus species widely known as a traditional medicine. Exploring the beneficial peptides by hydrolysis using pepsin and trypsin has been extensively performed to identify new bioactive natural products. A multifunctional peptide that expresses potential scavenging activity and tyrosinase inhibition is valuable in therapeutic and cosmetic applications. This study aimed to identify and investigate the effects of a novel multifunctional peptide from Lingzhi on the melanogenic enzymes in melanoma cells by a targeted-proteomics approach. The multifunctional peptide
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Freitas e Silva, Kleber S., Lívia C. Silva, Relber A. Gonçales, Bruno J. Neves, Célia M. A. Soares, and Maristela Pereira. "Setting New Routes for Antifungal Drug Discovery Against Pathogenic Fungi." Current Pharmaceutical Design 26, no. 14 (2020): 1509–20. http://dx.doi.org/10.2174/1381612826666200317125956.

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: Fungal diseases are life-threatening to human health and responsible for millions of deaths around the world. Fungal pathogens lead to a high number of morbidity and mortality. Current antifungal treatment comprises drugs, such as azoles, echinocandins, and polyenes and the cure is not guaranteed. In addition, such drugs are related to severe side effects and the treatment lasts for an extended period. Thus, setting new routes for the discovery of effective and safe antifungal drugs should be a priority within the health care system. The discovery of alternative and efficient antifungal drug
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Gubbens, Jacob, Hua Zhu, Geneviève Girard, et al. "Natural Product Proteomining, a Quantitative Proteomics Platform, Allows Rapid Discovery of Biosynthetic Gene Clusters for Different Classes of Natural Products." Chemistry & Biology 21, no. 6 (2014): 707–18. http://dx.doi.org/10.1016/j.chembiol.2014.03.011.

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Genilloud, Olga. "Mining Actinomycetes for Novel Antibiotics in the Omics Era: Are We Ready to Exploit This New Paradigm?" Antibiotics 7, no. 4 (2018): 85. http://dx.doi.org/10.3390/antibiotics7040085.

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The current spread of multi-drug resistance in a number of key pathogens and the lack of therapeutic solutions in development to address most of the emerging infections in the clinic that are difficult to treat have become major concerns. Microbial natural products represent one of the most important sources for the discovery of potential new antibiotics and actinomycetes have been one of the most relevant groups that are prolific producers of these bioactive compounds. Advances in genome sequencing and bioinformatic tools have collected a wealth of knowledge on the biosynthesis of these molec
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Dissertations / Theses on the topic "Drug discovery; natural products; proteomics"

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Demers, Danielle H. "Chemical Investigations of Fungal Natural Products for Drug Discovery." Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/6825.

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Natural products have, historically, played an important role in drug discovery. Nevertheless, drug resistance, pathogen evolution, and global climate change threaten human health and nearly all current anti-infective treatments on the market today. It is undeniable that new drug discovery efforts are needed with increasing urgency. Bolstered by a rich history of discovering treatments in the world around us, natural products chemists continue to look to the environment with increasing understanding and emerging technologies that allow efficient, effective isolation of new chemical entities. T
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Dinarvand, Mojdeh. "Discovery and development of novel antibacterials from natural products." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/18569.

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Methicillin-resistant Staphylococcus aureus (MRSA) is a major human pathogen associated with a variety of moderate to severe infections. The multi-drug resistant nature of this pathogen makes treatment difficult. The main aim of this study was to screen a library of marine samples for novel compounds with antibacterial activity. A high-throughput assay was developed to identify active extracts, followed by determination of minimum inhibitory concentrations (MICs) for hits. The toxicity of marine samples was measured against different cells lines. Crude extracts were purified using column chrom
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Larsson, Sonny. "Mistletoes and Thionins : as Selection Models in Natural Products Drug Discovery." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7705.

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Hatherley, Rowan. "Structural bioinformatics studies and tool development related to drug discovery." Thesis, Rhodes University, 2016. http://hdl.handle.net/10962/d1020021.

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This thesis is divided into two distinct sections which can be combined under the broad umbrella of structural bioinformatics studies related to drug discovery. The first section involves the establishment of an online South African natural products database. Natural products (NPs) are chemical entities synthesised in nature and are unrivalled in their structural complexity, chemical diversity, and biological specificity, which has long made them crucial to the drug discovery process. South Africa is rich in both plant and marine biodiversity and a great deal of research has gone into isolatin
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Huffman, Olivia G. "Drug Discovery: identification of Anticancer Properties of Podophyllotoxin Analogues." Youngstown State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1588874335556129.

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Hagos, Selam. "Chemical Investigation of Bioactive Marine Extracts." Scholar Commons, 2018. https://scholarcommons.usf.edu/etd/7301.

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Natural products have been a fundamental source of medicinal scaffolds for decades; with sixty percent of marketed drugs. Many synthetic chemists are focused on synthesizing potent and nontoxic compounds for pharmaceutical targets, however, nature is still proving to be a source of new bioactive compounds. Produced by the host organism for defense, reproduction and communication, secondary metabolites also demonstrate promising bioactivity against human pathogens. Hence, natural product chemists continue their quest for new leads. As a continuation
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Voser, Tanja M. "Marine Biodiscovery - An Exploration of Chemical Diversity, Antibiotic Discovery, and Invertebrate Natural Product Chemistry." Thesis, Griffith University, 2022. http://hdl.handle.net/10072/414294.

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This thesis covers a wide range of research on marine natural products with a focus on their role in drug discovery. Chapter 1 starts with a general introduction to marine natural product chemistry, describing current trends and problems. It gives an insight into the importance of the discovery of new antibiotics in this pressing time where multidrug-resistant bacteria are on the rise. Chapter 2 is a meta-analysis of current trends in marine microbial natural product research and an analysis of how much of their chemistry overlaps with the chemistry of terrestrial microbial natural products. O
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Turbyville, Thomas Jefferson. "Using Phylogenetically Conserved Stress Responses to Discover Natural Products with Anticancer Activity." Diss., Tucson, Arizona : University of Arizona, 2005. http://etd.library.arizona.edu/etd/GetFileServlet?file=file:///data1/pdf/etd/azu%5Fetd%5F1078%5F1%5Fm.pdf&type=application/pdf.

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Holland, Darren C. "Marine Natural Products Biodiscovery and Meta-analysis of their Bioactivities to Improve their Potential for Drug Discovery." Thesis, Griffith University, 2022. http://hdl.handle.net/10072/416310.

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Marine natural products biodiscovery continues to evolve into an increasingly more sophisticated and multidisciplinary field. Since the first reported marine compound in the 1970’s, there have been more than 33,000 marine natural products reported in the literature with seventeen marine-derived drugs currently approved for therapeutic use worldwide. Despite this, how much do we really know about marine natural product chemical space with respect to biological activity, and are we examining these precious resources against suitable disease targets that aim to maximise their potentials for drug
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Wang, Tao Verfasser], and Jeroen S. [Akademischer Betreuer] [Dickschat. "Discovery of antifungal and antibacterial volatile natural products and synthetic drug analogs / Tao Wang ; Betreuer: Jeroen S. Dickschat." Braunschweig : Technische Universität Braunschweig, 2018. http://d-nb.info/1175815454/34.

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Books on the topic "Drug discovery; natural products; proteomics"

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Genilloud, Olga, and Francisca Vicente, eds. Drug Discovery from Natural Products. Royal Society of Chemistry, 2012. http://dx.doi.org/10.1039/9781849734950.

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Koehn, Frank E., ed. Natural Products and Cancer Drug Discovery. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-4654-5.

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Singh, Joginder, Vineet Meshram, and Mahiti Gupta, eds. Bioactive Natural products in Drug Discovery. Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-1394-7.

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1951-, Grabley S., and Thiericke R. 1957-, eds. Drug discovery from nature. Springer, 1999.

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S, Grabley, and Thiericke R, eds. Drug discovery from nature. Springer-Verlag, 2000.

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D, Zhang Lixin Ph, and Demain A. L. 1927-, eds. Natural products: Drug discovery and therapeutic medicine. Humana Press, 2005.

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Kuhn, Cynthia M. Natural products: Drug discovery and therapeutic medicine. Humana, 2010.

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Cruz, Jorddy Neves, ed. Drug Discovery and Design Using Natural Products. Springer Nature Switzerland, 2023. http://dx.doi.org/10.1007/978-3-031-35205-8.

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Mulzer, J., and R. Bohlmann, eds. The Role of Natural Products in Drug Discovery. Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-662-04042-3.

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Royal Society of Chemistry (Great Britain), ed. Natural product chemistry for drug discovery. Royal Society of Chemistry, 2010.

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Book chapters on the topic "Drug discovery; natural products; proteomics"

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Spainhour, Charles B. "Natural Products." In Drug Discovery Handbook. John Wiley & Sons, Inc., 2005. http://dx.doi.org/10.1002/0471728780.ch1.

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Thorson, Jon S., and Thomas Vogt. "Glycosylated Natural Products." In Carbohydrate-Based Drug Discovery. Wiley-VCH Verlag GmbH & Co. KGaA, 2005. http://dx.doi.org/10.1002/3527602437.ch25.

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Howes, Melanie-Jayne R. "Alkaloids and Drug Discovery for Neurodegenerative Diseases." In Natural Products. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-22144-6_43.

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Manjunatha*, Ujjini, Fumiaki Yokokawa, Meera Gurumurthy, and Thomas Dick. "Chapter 14. Natural Products: New Agents Against MDR Tuberculosis." In Drug Discovery. Royal Society of Chemistry, 2012. http://dx.doi.org/10.1039/9781849734950-00307.

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Müller, H., O. Brackhagen, R. Brunne, T. Henkel, and F. Reichel. "Natural Products in Drug Discovery." In The Role of Natural Products in Drug Discovery. Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-662-04042-3_7.

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Bianchi, S. E., L. A. Frank, I. A. Alves, and M. R. Serafini. "Drug Discovery from Natural Products." In Nanophytomedicine. CRC Press, 2022. http://dx.doi.org/10.1201/9781003231745-1.

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Mishra, Bhuwan B., Navneet Kishore, Rakesh K. Singh, and Vinod Kumar Tiwari. "Scope of Alkaloids in Antileishmanial Drug Discovery and Development." In Natural Products. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-22144-6_91.

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Mishra, Tripti, Vinod K. Tiwari, and Bhuwan B. Mishra. "Scope of Alkaloids in Antileishmanial Drug Discovery and Development." In Natural Products. Springer Berlin Heidelberg, 2025. https://doi.org/10.1007/978-3-642-36202-6_91-1.

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Singh, Inder Pal, Furkan Ahmad, Debanjan Chatterjee, Ruchi Bajpai, and Neha Sengar. "Natural Products: Drug Discovery and Development." In Drug Discovery and Development. Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-5534-3_2.

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Genilloud*, Olga, and Francisca Vicente*. "Chapter 11. Novel Approaches to Exploit Natural Products from Microbial Resources." In Drug Discovery. Royal Society of Chemistry, 2012. http://dx.doi.org/10.1039/9781849734950-00221.

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Conference papers on the topic "Drug discovery; natural products; proteomics"

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Obeyesekere, Nihal, and Thusitha Wickramarachchi. "Transition from Combinatorial Chemistry to Present Day Robotics in Product Development for Oil Field Chemicals." In MECC 2023. AMPP, 2023. https://doi.org/10.5006/mecc2023-20245.

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Abstract In this paper, the slow evolution of combinatorial chemistry from its dawn in 1980’s to today’s oil field product development is discussed. Combinatorial chemistry comprises chemical synthetic methods that make it possible to prepare a vast number of compounds in a single process. These compound libraries can be made as mixtures, sets of individual compounds or chemical structures generated by computer software. This phenomenon was first invented by Arpad Furka (Lorand University, Budapest) in 1982. He described the principle of it, the combinatorial synthesis and a deconvolution proc
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"In Silico Drug Discovery using Natural Products." In INTERNATIONAL CONFERENCE ON BIOLOGICAL RESEARCH AND APPLIED SCIENCE. Jinnah University for Women, 2024. http://dx.doi.org/10.37962/ibras/2024/14.

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Petersen, F. "Natural products based molecules for target and drug discovery in pharmaceutical research." In GA 2017 – Book of Abstracts. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1608577.

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Nabatanzi, Alice. "The Future of Africa’s Natural Products in Drug Discovery and Development: Trends and Challenges." In GA – 69th Annual Meeting 2021, Virtual conference. Georg Thieme Verlag, 2021. http://dx.doi.org/10.1055/s-0041-1736749.

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Hamon, Morgan, Kirn Cramer, Sachin Jambovane, Jing Dai, Ali Khademhosseini, and Jong Wook Hong. "Wide Range Logarithmic Gradient Formation for Cell Response." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53710.

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Recently, the number of potential drug targets has dramatically increased because of the recent completion of the human genome sequencing and the progress in genomics and proteomics. In parallel, the number of new drugs for those targets has also been increased due to the use of combinatorial synthesis and the increased access to natural molecules [1]. However, this has not increased consequently the number of approved new drugs delivered to patients [2]. Indeed the drug discovery process is still limited by numbers of challenges; among them the need to analyze in more rapid and accurate manne
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Rubani, Muhammad, and Arli Aditya Parikesit. "Molecular Simulation of Coffee Beans’ Natural Products as Lead Compounds for Stroke Remedy." In The 6th International Conference on Science and Engineering. Trans Tech Publications Ltd, 2024. http://dx.doi.org/10.4028/p-k5delo.

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The consumption of coffee has its health benefits and its risks, one of the risks is mostly related to cardiovascular diseases. One of the diseases is hypertension which is considered “the silent killer” as it is a serious condition which promotes other complications and typically has no symptoms for a period of time until it has done significant damage. Acute hypertension can lead to a stroke. It is a very serious medical condition where the blood flow to the brain is poor, causing the death of cells within the brain. Some medications, surgeries and other healthcare programs are capable of co
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Millen, David R. "AI in Healthcare practice: opportunities and challenges for clinical decision support systems." In XVIII Simpósio Brasileiro de Fatores Humanos em Sistemas Computacionais. Sociedade Brasileira de Computação - SBC, 2019. http://dx.doi.org/10.5753/ihc.2019.8372.

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In the past few years there has been great optimism about the potential benefits of incorporating AI (cognitive) capabilities into healthcare products and services. Indeed, progress in Natural Language Processing (NLP) has made electronic health records both more accessible and comprehensible, advances in image processing algorithms has helped to early identify tumors, and large datasets with new discovery services can help with breakthrough insights in life sciences and drug discovery. Importantly, new AI-based solutions are embedded in the sociotechnical systems of clinical care and within c
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Ahmed, Faez, Yaxin Cui, Yan Fu, and Wei Chen. "A Graph Neural Network Approach for Product Relationship Prediction." In ASME 2021 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/detc2021-69462.

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Abstract Graph representation learning has revolutionized many artificial intelligence and machine learning tasks in recent years, ranging from combinatorial optimization, drug discovery, recommendation systems, image classification, social network analysis to natural language understanding. This paper shows their efficacy in modeling relationships between products and making predictions for unseen product networks. By representing products as nodes and their relationships as edges of a graph, we show how an inductive graph neural network approach, named GraphSAGE, can efficiently learn contin
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