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Journal articles on the topic 'Drug discovery; natural products; proteomics'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Huang, Huibin, and Jun He. "Proteomics in Natural Products: An Overview of Bioactive Compounds Research." Journal of Pharmaceutical and Biomedical Sciences 12, no. 02 (2022): 26–39. https://doi.org/10.5281/zenodo.7116089.

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Proteomics originated from 2-dimensional electrophoresis more than thirty years ago. Technological advances have made proteomics one of the most flourishing areas of modern biotechnology research. Proteomics mainly characterizes protein functions, protein–protein interactions, and protein modification in cells, tissues or animals. The integration of proteomic data helps to screen bioactive compounds, biomarkers of diseases, or signaling pathways in cells or the whole body. Natural products are valuable resources that contain a variety of bioactive compounds. However, the mechanisms of ac

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Wright, M. H., and S. A. Sieber. "Chemical proteomics approaches for identifying the cellular targets of natural products." Natural Product Reports 33, no. 5 (2016): 681–708. http://dx.doi.org/10.1039/c6np00001k.

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Piggott, Andrew, and Peter Karuso. "Quality not Quantity: The Role of Marine Natural Products in Drug Discovery and Reverse Chemical Proteomics." Marine Drugs 3, no. 2 (2005): 36–63. http://dx.doi.org/10.3390/md302036.

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Machado, António, Lizbeth Zamora-Mendoza, Frank Alexis, and José Miguel Álvarez-Suarez. "Use of Plant Extracts, Bee-Derived Products, and Probiotic-Related Applications to Fight Multidrug-Resistant Pathogens in the Post-Antibiotic Era." Future Pharmacology 3, no. 3 (2023): 535–67. http://dx.doi.org/10.3390/futurepharmacol3030034.

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The ‘post-antibiotic’ era is near according to the World Health Organization (WHO). It is well known, due to the work of the scientific community, that drugs (antibiotics, antifungals, and other antimicrobial agents) are continuously becoming less effective, and multidrug-resistant (MDR) pathogens are on the rise. This scenario raises concerns of an impending global infectious disease crisis, wherein a simple opportunistic infection could be deadly for humans. The war against MDR pathogens requires innovation and a multidisciplinary approach. The present study provides comprehensive coverage o

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Chele, Kekeletso H., Lizelle A. Piater, Justin J. J. van der van der Hooft, and Fidele Tugizimana. "Bridging Ethnobotanical Knowledge and Multi-Omics Approaches for Plant-Derived Natural Product Discovery." Metabolites 15, no. 6 (2025): 362. https://doi.org/10.3390/metabo15060362.

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For centuries, plant-derived natural products (NPs) have been fundamental to traditional medicine, providing essential therapeutic compounds. Ethnobotanical knowledge has historically guided NP discovery, leading to the identification of key pharmaceuticals such as aspirin, morphine, and artemisinin. However, conventional bioactivity-guided fractionation methods for NP isolation are labour-intensive and can result in the loss of bioactive properties due to the focus on a single compound. Advances in omics sciences—genomics, transcriptomics, proteomics, metabolomics, and phenomics—coupled with

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Satheeshkumar, Nanjappan, Narayanan Nisha, Nirmal Sonali, Jayabalan Nirmal, Gaurav K. Jain, and Vudataneni Spandana. "Analytical Profiling of Bioactive Constituents from Herbal Products, using Metabolomics - A Review." Natural Product Communications 7, no. 8 (2012): 1934578X1200700. http://dx.doi.org/10.1177/1934578x1200700837.

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Natural products have been the source of many active substances in drug discovery. There are several strategies/approaches in the field of biology, drug discovery, molecular and cell biology for identification of bioactive molecules. Metabolomics involves fewer complexities, is more precise and provides more relevant data compared with other techniques. This approach is based on the application of new technologies and provides real-world end points that complement and help in the interpretation of genomic and proteomic data in drug discovery. It has also been proven to be a valuable analytical

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Yingchutrakul, Yodying, Sucheewin Krobthong, Kiattawee Choowongkomon, et al. "Discovery of a Multifunctional Octapeptide from Lingzhi with Antioxidant and Tyrosinase Inhibitory Activity." Pharmaceuticals 15, no. 6 (2022): 684. http://dx.doi.org/10.3390/ph15060684.

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Ganoderma lucidum or Lingzhi is a fungus species widely known as a traditional medicine. Exploring the beneficial peptides by hydrolysis using pepsin and trypsin has been extensively performed to identify new bioactive natural products. A multifunctional peptide that expresses potential scavenging activity and tyrosinase inhibition is valuable in therapeutic and cosmetic applications. This study aimed to identify and investigate the effects of a novel multifunctional peptide from Lingzhi on the melanogenic enzymes in melanoma cells by a targeted-proteomics approach. The multifunctional peptide

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Freitas e Silva, Kleber S., Lívia C. Silva, Relber A. Gonçales, Bruno J. Neves, Célia M. A. Soares, and Maristela Pereira. "Setting New Routes for Antifungal Drug Discovery Against Pathogenic Fungi." Current Pharmaceutical Design 26, no. 14 (2020): 1509–20. http://dx.doi.org/10.2174/1381612826666200317125956.

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: Fungal diseases are life-threatening to human health and responsible for millions of deaths around the world. Fungal pathogens lead to a high number of morbidity and mortality. Current antifungal treatment comprises drugs, such as azoles, echinocandins, and polyenes and the cure is not guaranteed. In addition, such drugs are related to severe side effects and the treatment lasts for an extended period. Thus, setting new routes for the discovery of effective and safe antifungal drugs should be a priority within the health care system. The discovery of alternative and efficient antifungal drug

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9

Gubbens, Jacob, Hua Zhu, Geneviève Girard, et al. "Natural Product Proteomining, a Quantitative Proteomics Platform, Allows Rapid Discovery of Biosynthetic Gene Clusters for Different Classes of Natural Products." Chemistry & Biology 21, no. 6 (2014): 707–18. http://dx.doi.org/10.1016/j.chembiol.2014.03.011.

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Genilloud, Olga. "Mining Actinomycetes for Novel Antibiotics in the Omics Era: Are We Ready to Exploit This New Paradigm?" Antibiotics 7, no. 4 (2018): 85. http://dx.doi.org/10.3390/antibiotics7040085.

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The current spread of multi-drug resistance in a number of key pathogens and the lack of therapeutic solutions in development to address most of the emerging infections in the clinic that are difficult to treat have become major concerns. Microbial natural products represent one of the most important sources for the discovery of potential new antibiotics and actinomycetes have been one of the most relevant groups that are prolific producers of these bioactive compounds. Advances in genome sequencing and bioinformatic tools have collected a wealth of knowledge on the biosynthesis of these molec

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Zhang, Peixi, Ziqing Zhang, Jie Li, et al. "Advanced PROTAC and Quantitative Proteomics Strategy Reveals Bax Inhibitor-1 as a Critical Target of Icaritin in Burkitt Lymphoma." International Journal of Molecular Sciences 25, no. 23 (2024): 12944. https://doi.org/10.3390/ijms252312944.

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Understanding the molecular targets of natural products is crucial for elucidating their mechanisms of action, mitigating toxicity, and uncovering potential therapeutic pathways. Icaritin (ICT), a bioactive flavonoid, demonstrates significant anti-tumor activity but lacks defined molecular targets. This study employs an advanced strategy integrating proteolysis targeting chimera (PROTAC) technology with quantitative proteomics to identify ICT’s key targets. A library of 22 ICT-based PROTAC derivatives were synthesized, among which LJ-41 exhibited a superior IC50 of 5.52 μM against Burkitt lymp

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Carsanba, Erdem, Manuela Pintado, and Carla Oliveira. "Fermentation Strategies for Production of Pharmaceutical Terpenoids in Engineered Yeast." Pharmaceuticals 14, no. 4 (2021): 295. http://dx.doi.org/10.3390/ph14040295.

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Terpenoids, also known as isoprenoids, are a broad and diverse class of plant natural products with significant industrial and pharmaceutical importance. Many of these natural products have antitumor, anti-inflammatory, antibacterial, antiviral, and antimalarial effects, support transdermal absorption, prevent and treat cardiovascular diseases, and have hypoglycemic activities. Production of these compounds are generally carried out through extraction from their natural sources or chemical synthesis. However, these processes are generally unsustainable, produce low yield, and result in wasting

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13

Li, Fangyi, Biaobiao Jiang, Yuqin Luo, et al. "Discovery of a Novel Class of Acylthiourea-Containing Isoxazoline Insecticides against Plutella xylostella." Molecules 28, no. 8 (2023): 3300. http://dx.doi.org/10.3390/molecules28083300.

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Isoxazoline structures are widely found in natural products and are rich in biological activities. This study discloses the development of a series of novel isoxazoline derivatives by introducing acylthiourea fragments to access insecticidal activity. All synthetic compounds were examined for their insecticidal activity against Plutella xylostella, with results showing moderate to strong activity. Based on this, the structure–activity relationship analysis was carried out via the constructed three-dimensional quantitative structure–activity relationship model to further guide the structure opt

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Ali, Hamid, Abdus Samad, Amar Ajmal, et al. "Identification of Drug Targets and Their Inhibitors in Yersinia pestis Strain 91001 through Subtractive Genomics, Machine Learning, and MD Simulation Approaches." Pharmaceuticals 16, no. 8 (2023): 1124. http://dx.doi.org/10.3390/ph16081124.

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Yersinia pestis, the causative agent of plague, is a Gram-negative bacterium. If the plague is not properly treated it can cause rapid death of the host. Bubonic, pneumonic, and septicemic are the three types of plague described. Bubonic plague can progress to septicemic plague, if not diagnosed and treated on time. The mortality rate of pneumonic and septicemic plague is quite high. The symptom-defining disease is the bubo, which is a painful lymph node swelling. Almost 50% of bubonic plague leads to sepsis and death if not treated immediately with antibiotics. The host immune response is slo

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Vilaboa, Nuria, Juan Antonio Lopez, Marco de Mesa, et al. "Disruption of Proteostasis by Natural Products and Synthetic Compounds That Induce Pervasive Unfolding of Proteins: Therapeutic Implications." Pharmaceuticals 16, no. 4 (2023): 616. http://dx.doi.org/10.3390/ph16040616.

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Exposure of many cancer cells, including multiple myeloma cells, to cytotoxic concentrations of natural products celastrol and withaferin A or synthetic compounds of the IHSF series resulted in denaturation of a luciferase reporter protein. Proteomic analysis of detergent-insoluble extract fractions from HeLa-derived cells revealed that withaferin A, IHSF058 and IHSF115 caused denaturation of 915, 722 and 991 of 5132 detected cellular proteins, respectively, of which 440 were targeted by all three compounds. Western blots showed that important fractions of these proteins, in some cases approac

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Siriwaseree, Jeeraprapa, Yodying Yingchutrakul, Pawitrabhorn Samutrtai, et al. "Exploring the Apoptotic-Induced Biochemical Mechanism of Traditional Thai Herb (Kerra™) Extract in HCT116 Cells Using a Label-Free Proteomics Approach." Medicina 59, no. 8 (2023): 1376. http://dx.doi.org/10.3390/medicina59081376.

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Background and Objectives: Natural products have proven to be a valuable source for the discovery of new candidate drugs for cancer treatment. This study aims to investigate the potential therapeutic effects of “Kerra™”, a natural extract derived from a mixture of nine medicinal plants mentioned in the ancient Thai scripture named the Takxila Scripture, on HCT116 cells. Materials and Methods: In this study, the effect of the Kerra™ extract on cancer cells was assessed through cell viability assays. Apoptotic activity was evaluated by examining the apoptosis characteristic features. A proteomic

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17

Moyer, Tessa B., Amanda M. Brechbill, and Leslie M. Hicks. "Mass Spectrometric Identification of Antimicrobial Peptides from Medicinal Seeds." Molecules 26, no. 23 (2021): 7304. http://dx.doi.org/10.3390/molecules26237304.

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Traditional medicinal plants contain a variety of bioactive natural products including cysteine-rich (Cys-rich) antimicrobial peptides (AMPs). Cys-rich AMPs are often crosslinked by multiple disulfide bonds which increase their resistance to chemical and enzymatic degradation. However, this class of molecules is relatively underexplored. Herein, in silico analysis predicted 80–100 Cys-rich AMPs per species from three edible traditional medicinal plants: Linum usitatissimum (flax), Trifolium pratense (red clover), and Sesamum indicum (sesame). Bottom-up proteomic analysis of seed peptide extrac

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18

Hernández, Ángela-Patricia, Lorea Chaparro-González, Olga Garzo-Sánchez, et al. "Podophyllic Aldehyde, a Podophyllotoxin Derivate, Elicits Different Cell Cycle Profiles Depending on the Tumor Cell Line: A Systematic Proteomic Analysis." International Journal of Molecular Sciences 25, no. 9 (2024): 4631. http://dx.doi.org/10.3390/ijms25094631.

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When new antitumor therapy drugs are discovered, it is essential to address new target molecules from the point of view of chemical structure and to carry out efficient and systematic evaluation. In the case of natural products and derived compounds, it is of special importance to investigate chemomodulation to further explore antitumoral pharmacological activities. In this work, the compound podophyllic aldehyde, a cyclolignan derived from the chemomodulation of the natural product podophyllotoxin, has been evaluated for its viability, influence on the cell cycle, and effects on intracellular

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19

Sang, Chun-Yan, Yi-Dan Zheng, Li-Mei Ma, et al. "Potential Anti-Tumor Activity of Nardoguaianone L Isolated from Nardostachys jatamansi DC. in SW1990 Cells." Molecules 27, no. 21 (2022): 7490. http://dx.doi.org/10.3390/molecules27217490.

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Natural products (NPs) were a rich source of diverse bioactive molecules. Most anti-tumor agents were built on natural scaffolds. Nardostachys jatamansi DC. was an important plant used to process the traditional Chinese herbal medicines “gansong”. Pancreatic cancer was the fourth most common cause of cancer-related death in the world. Hence, there was an urgent need to develop novel agents for the treatment of pancreatic cancer. In this paper, nardoguaianone L (G-6) is isolated from N. jatamansi, which inhibited SW1990 cells colony formation and cell migration, and induced cell apoptosis. Furt

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20

Esch, Stefan, Simone König, Bertan Bopp, Joachim Jose, Simone Brandt, and Andreas Hensel. "Cryptotanshinone from Salvia miltiorrhiza Roots Reduces Cytokeratin CK1/10 Expression in Keratinocytes by Activation of Peptidyl-prolyl-cis-trans-isomerase FKBP1A." Planta Medica 85, no. 07 (2018): 552–62. http://dx.doi.org/10.1055/a-0660-0441.

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AbstractCryptotanshinone (CTS) (1 µM) from the roots of Salvia miltiorrhiza exerts a strong influence on the terminal differentiation of human keratinocytes (HaCaT cell line, primary natural human keratinocytes) and downregulates the expression of differentiation-specific cytokeratins CK1 and CK10 on protein and gene level. Other differentiation specific proteins as involucrin, filaggrin, loricrin, and transglutaminase were not affected to a higher extent. CTS (1 µM) did not influence the cell viability and the proliferation of keratinocytes. Using a combination of drug affinity response targe

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21

Roggo, Silvio. "Natural Products in Drug Discovery." CHIMIA International Journal for Chemistry 61, no. 6 (2007): 312. http://dx.doi.org/10.2533/chimia.2007.312.

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22

Ji, Hong‐Fang, Xue‐Juan Li, and Hong‐Yu Zhang. "Natural products and drug discovery." EMBO reports 10, no. 3 (2009): 194–200. http://dx.doi.org/10.1038/embor.2009.12.

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23

Marrero, Faz E. "Natural products for drug discovery." Toxicology Letters 259 (October 2016): S15. http://dx.doi.org/10.1016/j.toxlet.2016.07.074.

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24

Gullo, Vincent P., James McAlpine, Kin S. Lam, Dwight Baker, and Frank Petersen. "Drug discovery from natural products." Journal of Industrial Microbiology & Biotechnology 33, no. 7 (2006): 523–31. http://dx.doi.org/10.1007/s10295-006-0107-2.

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25

HARVEY, A. "Natural products in drug discovery." Drug Discovery Today 13, no. 19-20 (2008): 894–901. http://dx.doi.org/10.1016/j.drudis.2008.07.004.

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26

Newman, David J. "Natural Products and Cancer Drug Discovery." Future Oncology 9, no. 7 (2013): 949–50. http://dx.doi.org/10.2217/fon.13.69.

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27

Rastelli, Giulio, Federica Pellati, Luca Pinzi, and Maria Cristina Gamberini. "Repositioning Natural Products in Drug Discovery." Molecules 25, no. 5 (2020): 1154. http://dx.doi.org/10.3390/molecules25051154.

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28

Abdel-Razek, Ahmed S., Mehrez E. El-Naggar, Ahmed Allam, Osama M. Morsy, and Sarah I. Othman. "Microbial Natural Products in Drug Discovery." Processes 8, no. 4 (2020): 470. http://dx.doi.org/10.3390/pr8040470.

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Over a long period of time, humans have explored many natural resources looking for remedies of various ailments. Traditional medicines have played an intrinsic role in human life for thousands of years, with people depending on medicinal plants and their products as dietary supplements as well as using them therapeutically for treatment of chronic disorders, such as cancer, malaria, diabetes, arthritis, inflammation, and liver and cardiac disorders. However, plant resources are not sufficient for treatment of recently emerging diseases. In addition, the seasonal availability and other politic

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29

Cooper, Edwin L. "Drug Discovery, CAM and Natural Products." Evidence-Based Complementary and Alternative Medicine 1, no. 3 (2004): 215–17. http://dx.doi.org/10.1093/ecam/neh032.

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30

Mangla, Kanchan, and Rao Nargis Jahan. "Pharmacognosy: Natural products in drug discovery." Pharma Innovation 8, no. 4 (2019): 1276–80. http://dx.doi.org/10.22271/tpi.2019.v8.i4s.25511.

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31

Xu, Zhihong, Barrett Eichler, Eytan A. Klausner, Jetty Duffy-Matzner, and Weifan Zheng. "Lead/Drug Discovery from Natural Resources." Molecules 27, no. 23 (2022): 8280. http://dx.doi.org/10.3390/molecules27238280.

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Natural products and their derivatives have been shown to be effective drug candidates against various diseases for many years. Over a long period of time, nature has produced an abundant and prosperous source pool for novel therapeutic agents with distinctive structures. Major natural-product-based drugs approved for clinical use include anti-infectives and anticancer agents. This paper will review some natural-product-related potent anticancer, anti-HIV, antibacterial and antimalarial drugs or lead compounds mainly discovered from 2016 to 2022. Structurally typical marine bioactive products

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32

Suresh, P., K. Bhagya Lakshmi, G. Sailaja, N. L. Janaki, and K. Aruna. "NATURAL PRODUCTS: THE ROLE IN DRUG DISCOVERY." International Journal of Advanced Research 12, no. 11 (2024): 1010–13. https://doi.org/10.21474/ijar01/19912.

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Natural products have been used since ancient times and in myth for the treatment of numerous conditions and ails. Natural products and their derivations have been honored for numerous times as a source of remedial agents and of structural diversity. still, natural products are nt medicines. Theyre products of nature and through natural assays theyre linked as leads which come campaigners for medicine development. further than 50 of the medicines that are in the request decide from natural resource. still, in addition to their chemical structure diversity and their biodiversity, the developmen

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33

G. Grothaus, Paul, Gordon M. Cragg, and David J. Newman. "Plant Natural Products in Anticancer Drug Discovery." Current Organic Chemistry 14, no. 16 (2010): 1781–91. http://dx.doi.org/10.2174/138527210792927708.

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34

Gehrtz, Paul, and Nir London. "Electrophilic Natural Products as Drug Discovery Tools." Trends in Pharmacological Sciences 42, no. 6 (2021): 434–47. http://dx.doi.org/10.1016/j.tips.2021.03.008.

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35

Calderón, Angela I., Johayra Simithy-Williams, and Mahabir P. Gupta. "Antimalarial natural products drug discovery in Panama." Pharmaceutical Biology 50, no. 1 (2011): 61–71. http://dx.doi.org/10.3109/13880209.2011.602417.

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36

Lahlou, Mouhssen. "Screening of natural products for drug discovery." Expert Opinion on Drug Discovery 2, no. 5 (2007): 697–705. http://dx.doi.org/10.1517/17460441.2.5.697.

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37

Ojima, Iwao. "Modern Natural Products Chemistry and Drug Discovery." Journal of Medicinal Chemistry 51, no. 9 (2008): 2587–88. http://dx.doi.org/10.1021/jm701291u.

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38

Cragg, Gordon M., David J. Newman, and Kenneth M. Snader. "Natural Products in Drug Discovery and Development." Journal of Natural Products 60, no. 1 (1997): 52–60. http://dx.doi.org/10.1021/np9604893.

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Cirla, Alessandra, and John Mann. "Combretastatins: from natural products to drug discovery." Natural Product Reports 20, no. 6 (2003): 558. http://dx.doi.org/10.1039/b306797c.

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Knight, V., J. J. Sanglier, D. DiTullio, et al. "Diversifying microbial natural products for drug discovery." Applied Microbiology and Biotechnology 62, no. 5-6 (2003): 446–58. http://dx.doi.org/10.1007/s00253-003-1381-9.

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Wruck, Wasco, Afua Kobi Ampem Genfi, and James Adjaye. "Natural Products in Renal-Associated Drug Discovery." Antioxidants 12, no. 8 (2023): 1599. http://dx.doi.org/10.3390/antiox12081599.

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The global increase in the incidence of kidney failure constitutes a major public health problem. Kidney disease is classified into acute and chronic: acute kidney injury (AKI) is associated with an abrupt decline in kidney function and chronic kidney disease (CKD) with chronic renal failure for more than three months. Although both kidney syndromes are multifactorial, inflammation and oxidative stress play major roles in the diversity of processes leading to these kidney malfunctions. Here, we reviewed various publications on medicinal plants with antioxidant and anti-inflammatory properties

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Chen, Yunqiu, Michelle Unger, Ioanna Ntai, et al. "Gobichelin A and B: mixed-ligandsiderophores discovered using proteomics." MedChemComm 4, no. 1 (2013): 233–38. http://dx.doi.org/10.1039/c2md20232h.

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Alam, Fahmida, Md Asiful Islam, Mohammad Amjad Kamal, and Siew Hua Gan. "Updates on Managing Type 2 Diabetes Mellitus with Natural Products: Towards Antidiabetic Drug Development." Current Medicinal Chemistry 25, no. 39 (2019): 5395–431. http://dx.doi.org/10.2174/0929867323666160813222436.

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Over the years, natural products have shown success as antidiabetics in in vitro, in vivo studies and clinical trials. Because natural product-derived drugs are more affordable and effective with fewer side-effects compared to conventional therapies, pharmaceutical research is increasingly leaning towards the discovery of new antidiabetic drugs from natural products targeting pathways or components associated with type 2 diabetes mellitus (T2DM) pathophysiology. However, the drug discovery process is very lengthy and costly with significant challenges. Therefore, various techniques are current

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Ali, Parniya Akbar, Farah Hanif, Hosna Nettour, and Mubashar Rehman. "Strategies and Techniques of Drug Discovery from Natural Products." Global Drug Design & Development Review II, no. I (2017): 34–43. http://dx.doi.org/10.31703/gdddr.2017(ii-i).04.

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New drugs are mostly obtained from Natural sources. The traditional and ethic medicines have provided evidence on the therapeutic properties and resulted in some distinguished drug discovery of natural products. The microorganisms and the endogenous active materials from human or animal have also become a significant approach to the discovery of a drug. Bioinformatics and artificial intelligence have facilitated the study and development of products. For discovery of natural products different software have been used. Different computational software needed in the future for the predicting fea

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45

Atanasov, Atanas G., Sergey B. Zotchev, Verena M. Dirsch, and Claudiu T. Supuran. "Natural products in drug discovery: advances and opportunities." Nature Reviews Drug Discovery 20, no. 3 (2021): 200–216. http://dx.doi.org/10.1038/s41573-020-00114-z.

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L. Harvey, Alan. "Plant Natural Products in Anti-Diabetic Drug Discovery." Current Organic Chemistry 14, no. 16 (2010): 1670–77. http://dx.doi.org/10.2174/138527210792927681.

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Mondal, Susmita, Santu Bandyopadhyay, Mrinal K. Ghosh, Sibabrata Mukhopadhyay, Siddhartha Roy, and Chitra Mandal. "Natural Products: Promising Resources for Cancer Drug Discovery." Anti-Cancer Agents in Medicinal Chemistry 12, no. 1 (2012): 49–75. http://dx.doi.org/10.2174/187152012798764697.

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Neves, Bruno, Carolina Andrade, and Pedro Cravo. "Natural Products as Leads in Schistosome Drug Discovery." Molecules 20, no. 2 (2015): 1872–903. http://dx.doi.org/10.3390/molecules20021872.

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Lahlou, Mouhssen. "The Success of Natural Products in Drug Discovery." Pharmacology & Pharmacy 04, no. 03 (2013): 17–31. http://dx.doi.org/10.4236/pp.2013.43a003.

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Harvey, Alan L., Rachel L. Clark, Simon P. Mackay, and Blair F. Johnston. "Current strategies for drug discovery through natural products." Expert Opinion on Drug Discovery 5, no. 6 (2010): 559–68. http://dx.doi.org/10.1517/17460441.2010.488263.

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