Relevant bibliographies by topics / Drug-excipient compatibility

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters

Academic literature on the topic 'Drug-excipient compatibility'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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Journal articles on the topic "Drug-excipient compatibility"

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Sims, Jonathan L., Judith A. Carreira, Daniel J. Carrier, et al. "A New Approach to Accelerated Drug-Excipient Compatibility Testing." Pharmaceutical Development and Technology 8, no. 2 (2003): 119–26. http://dx.doi.org/10.1081/pdt-120018476.

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da Silveira, Lucas Melo, Ariadne Botto Fiorot, Thiago Padovani Xavier, Maria Irene Yoshida, and Marcelo Antonio de Oliveira. "Drug-excipient compatibility assessment of solid formulations containing meloxicam." European Journal of Pharmaceutical Sciences 112 (January 2018): 146–51. http://dx.doi.org/10.1016/j.ejps.2017.11.015.

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CARLSON, E., W. CHANDLER, I. GALDO, T. KUDLA, and C. TA. "Automated Integrated Forced Degradation and Drug-Excipient Compatibility Studies." Journal of the Association for Laboratory Automation 10, no. 6 (2005): 374–80. http://dx.doi.org/10.1016/j.jala.2005.09.005.

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*P., Abhinandana and Ramarao Nadendla. "DRUG-EXCIPIENT COMPATABILITY STUDYON TORSEMIDE USING CURRENT TRENDS AND TECHNIQUES." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 07 (2019): 13521–30. https://doi.org/10.5281/zenodo.3344823.

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<em>A study of drug and excipient compatibility plays a major role in a pre-formulation study which is further useful in the development of dosage forms. The interaction between drug and excipient will affect the chemical nature and bioavailability of the drug which may test the safety and efficacy of the drug. Present research work was done to study the compatibility between Torsemideand different pharmaceutical excipients like cross-povidone (CP) , magnesium stearate (MS) , microcrystalline cellulose (MCC) and Anhydrous lactose (AL) by different analytical techniques like FTIR(Fourier transf
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Tandel, D. B., P. A. Shah, K. G. Patel, M. C. Gohel, V. T. Thakkar, and T. R. Gandhi. "IMPROVEMENT OF DISSOLUTION RATE OF FEBUXOSTAT USING HYBRID TECHNIQUE OF SPHERICAL CRYSTALLIZATION AND SOLID DISPERSION." INDIAN DRUGS 52, no. 09 (2015): 32–39. http://dx.doi.org/10.53879/id.52.09.10274.

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The present study was carried out with an aim to improve dissolution rate of febuxostat (FBX, BCSclass II) drug. Spherical agglomerates were prepared by hybrid technique of spherical crystallization and solid dispersion using different ratios of FBX and polymer (PVP K30, HPMC E3LV and chitosan). Drug excipient compatibility study was evaluated by Fourier transform infrared spectroscopy and X-ray diffractometry. Scanning electron microscopy was used for measurement of size of agglomerate. In vitro dissolution study of prepared spherical agglomerates was compared with untreated FBX and marketed
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Mohamed, Amir Ibrahim, Amal Abd-Elaal El-Khamery, Mohamed Ismail Herry, and Alaa Ibrahim Mohamed. "Compatibility Determination of Drug-Polymer, Drug-Excipient & Drug-Intravenous Admixtures Using Chemometric-assisted UVspectrophotometry." Current Pharmaceutical Analysis 16, no. 2 (2020): 125–42. http://dx.doi.org/10.2174/1573412914666181011142351.

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Purpose: A new multivariate chemometric approach was developed for fast and economic compatibility determinations of ranitidine hydrochloride (as model drug) with certain pharmaceutical; polymers (Alginate &amp; Chitosan), excipient (Lactose) and intravenous fluids (Dextrose, Ringer &amp; Dextrose/ Ringer). Binary mixtures of the drug and each item were prepared and investigated by chemometric- assisted UV- spectrophotometry as well as by HPLC reference method. Methods: Five drug concentration levels (0.004-0.025mg/ml) of test-mixtures were used and the average drug recovery percent after two
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Tita, Ioana Cristina, Lavinia Lupa, Bogdan Tita, Roxana Liana Stan, and Laura Vicas. "Compatibility Studies of Valsartan with Different Pharmaceutical Excipients." Revista de Chimie 70, no. 7 (2019): 2590–600. http://dx.doi.org/10.37358/rc.19.7.7386.

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Compatibility studies between active drugs and excipients are substantial in the pharmaceutical technology. Thermal analysis has been extensively used to obtain information about drug-excipient interactions and to perform pre-formulation studies of pharmaceutical dosage forms. The objective of the present study was to evaluate the compatibility of the valsartan (VALS) with pharmaceutical excipients of common use including diluents, binders, disintegrants, lubricants and solubilising agents. Thermogravimetry (TG), derivative thermogravimetry (DTG), but especially differential scanning calorimet
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Wang, Nannan, Huimin Sun, Jie Dong, and Defang Ouyang. "PharmDE: A new expert system for drug-excipient compatibility evaluation." International Journal of Pharmaceutics 607 (September 2021): 120962. http://dx.doi.org/10.1016/j.ijpharm.2021.120962.

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Chadha, Renu, and Swati Bhandari. "Drug–excipient compatibility screening—Role of thermoanalytical and spectroscopic techniques." Journal of Pharmaceutical and Biomedical Analysis 87 (January 2014): 82–97. http://dx.doi.org/10.1016/j.jpba.2013.06.016.

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Chaves, Luíse L., Larissa A. Rolim, Maria L. C. M. Gonçalves, et al. "Study of stability and drug-excipient compatibility of diethylcarbamazine citrate." Journal of Thermal Analysis and Calorimetry 111, no. 3 (2012): 2179–86. http://dx.doi.org/10.1007/s10973-012-2775-7.

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Dissertations / Theses on the topic "Drug-excipient compatibility"

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Da, Costa Mathews Claudia Cristina Magalhaes. "An investigation into polymeric excipient-drug compatibility in solid-liquid formulations." Thesis, University of Greenwich, 2007. http://gala.gre.ac.uk/6244/.

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The aim of the investigation was to develop a less empirical way of selecting an appropriate polymeric stabilising agent that would effectively maintain good dispersibility of a given drug substance with known physico-chemical properties. This was achieved by quantifying the adsorption of different polymers onto a range of drug substances from different solvent environments and to establish which physico-chemical properties of the polymers control their adsorption or non-adsorption onto a particular drug. The pharmaceutical actives, two proprietary compounds SB-223412, SB-204269 and loperamide
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Guimarães, Thiago Frances. "High shear melt granulation como alternativa de processo para granulação de artesunato." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/60/60137/tde-13122016-093419/.

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A modernização dos equipamentos de granulação por via úmida permitiu o desenvolvimento de diversas técnicas a partir do método tradicional. Dentre as técnicas desenvolvidas, a granulação por solidificação de materiais fundidos (GSMF) elimina o uso de solventes e diminui o tempo de processo. O presente trabalho teve por objetivo estudar o processo de granulação por solidificação de materiais fundidos usando um misturador/granulador do tipo high-shear (HSMG) e avaliar a influência das variáveis do processo nas características farmacotécnicas dos granulados e comprimidos obtidos. O artesunato foi
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Velásquez, Armijo Cristián Jesús. "Aplicação de métodos termo-analíticos e espectroscóspicos na avaliação do comportamento do fármaco isoniazida frente a adjuvantes tecnológicos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2003. http://hdl.handle.net/10183/144233.

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Os métodos termo-analíticos são ferramentas úteis na avaliação da compatibilidade entre fármacos e adjuvantes, com destaque à calorimetria exploratória diferencial. Neste trabalho foram avaliados a compatibilidade e o comportamento térmico entre a isoniazida e adjuvantes tecnológicos primários usualmente empregados em formas farmacêuticas sólidas. A compatibilidade foi examinada por meio da preparação de misturas físicas binárias do tipo fármaco/adjuvante. Foi investigada também a influência da granulação por via úmida e do processo de compactação para as misturas de isoniazida e adjuvantes co
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Book chapters on the topic "Drug-excipient compatibility"

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Saha, Gourab. "Artificial Intelligence (AI) in Formulation Development." In Computer Aided Drug Development. THINKPLUS PHARMA PUBLICATIONS, 2024. http://dx.doi.org/10.69613/tkh3gv85.

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Artificial intelligence has transformed pharmaceutical formulation development through advanced computational methods and predictive modeling. Machine learning algorithms analyze vast formulation databases to identify optimal excipient combinations and processing parameters. Deep learning networks predict drug-excipient compatibility, stability profiles, and dissolution characteristics with unprecedented accuracy. AI-powered systems accelerate preformulation studies by predicting physicochemical properties and potential formulation challenges. Neural networks optimize formulation compositions
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VADAGA, ANILKUMAR. "Pharmaceutical Aids." In A Text Book of Pharmaceutics for I Year Diploma in Pharmacy. THINKPLUS PHARMA PUBLICATIONS, 2024. http://dx.doi.org/10.69613/5zhfxq55.

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Pharmaceutical aids, also known as excipients, are essential components in drug formulations that serve various functions beyond the active pharmaceutical ingredient (API). These substances play crucial roles in enhancing the stability, bioavailability, manufacturability, and patient acceptability of medicinal products. Common categories of pharmaceutical aids include diluents, binders, disintegrants, lubricants, glidants, and preservatives. Each type of excipient contributes uniquely to the overall performance of the dosage form. For instance, diluents provide bulk to small-dose drugs, while
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Segall, Adriana. "Preformulation: Active Pharmaceutical Ingredient-Excipient Compatibility Studies." In Advanced Pharmacy. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815049428123010004.

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A relevant area of research in the preformulation phase for the development of new dosages is active pharmaceutical ingredient (API)-excipient compatibility. The possibilities of chemical and physical interaction of API and the excipients may affect how efficient and effective it is, while displaying an impact on the nature, stability and availability of API. The most common signs of deterioration of an API are changes in the color, taste, odor, polymorphic form, or crystallization (pharmaceutical incompatibility). These changes arise from chemical reactions with the excipient, leading to degr
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Kasturi, Madhavi. "Development of Liquisolid Compacts: An Approach for Dissolution Enhancement of Poorly Aqueous Soluble Drugs." In Drug Formulation Design [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.108706.

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Solubility plays a key role to achieve desired concentration of drug in systemic circulation and show its pharmacological action. An approach of liquisolid technique, developed by Spireas, was employed for the dissolution enhancement of poorly aqueous soluble drugs. Initially, liquid medication (liquid drug or drug solution or suspension in hydrophilic liquid vehicle) is transformed to free-flowing, non-sticky, compressible powder by the addition of suitable carrier material and coating materials for the development of liquisolid compacts. The postulated mechanism for enhanced solubility was i
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Balanagu, Haranatha Babu, Tatavarti SVS Gopala Krishna, Ramesh Cheruvu, and Buchi N. Nalluri. "Development and Validation of HPLC Method for Quantification of Parecoxib in Parecoxib Injection." In Current Trends in Drug Discovery, Development and Delivery (CTD4-2022). Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/9781837671090-00199.

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The purpose of the present study was to evaluate and optimize lyophilization cycle time for the manufacturing of Parecoxib Injection than reported longer lyophilization cycle times. Optimization of lyophilization cycle time reduces the manufacturing costs since lyophilization process involves longer times which incurs cost to the finished product. Optimization of lyophilization cycle was done by using inputs from the results of Differential Scanning Calorimetry (DSC), Differential Thermal Analysis (DTA) and Impedance analysis. HPLC method was developed for quantification of Parecoxib Active Ph
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Aftab Alam, Md, Aditya Sharma, Sakshi Sagar, Manjeet Kaur, Pramod Kumar Sharma, and Tarique Anwer. "11 Applications and molecular simulation strategies for excipient–excipient compatibility." In Computational Drug Delivery. De Gruyter, 2024. http://dx.doi.org/10.1515/9783111208671-011.

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You might also be interested in the extended bibliographies on the topic 'Drug-excipient compatibility' for particular source types:
Journal articles
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