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Journal articles on the topic 'Drug-excipient compatibility'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Sims, Jonathan L., Judith A. Carreira, Daniel J. Carrier, et al. "A New Approach to Accelerated Drug-Excipient Compatibility Testing." Pharmaceutical Development and Technology 8, no. 2 (2003): 119–26. http://dx.doi.org/10.1081/pdt-120018476.

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2

da Silveira, Lucas Melo, Ariadne Botto Fiorot, Thiago Padovani Xavier, Maria Irene Yoshida, and Marcelo Antonio de Oliveira. "Drug-excipient compatibility assessment of solid formulations containing meloxicam." European Journal of Pharmaceutical Sciences 112 (January 2018): 146–51. http://dx.doi.org/10.1016/j.ejps.2017.11.015.

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3

CARLSON, E., W. CHANDLER, I. GALDO, T. KUDLA, and C. TA. "Automated Integrated Forced Degradation and Drug-Excipient Compatibility Studies." Journal of the Association for Laboratory Automation 10, no. 6 (2005): 374–80. http://dx.doi.org/10.1016/j.jala.2005.09.005.

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4

*P., Abhinandana and Ramarao Nadendla. "DRUG-EXCIPIENT COMPATABILITY STUDYON TORSEMIDE USING CURRENT TRENDS AND TECHNIQUES." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 07 (2019): 13521–30. https://doi.org/10.5281/zenodo.3344823.

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<em>A study of drug and excipient compatibility plays a major role in a pre-formulation study which is further useful in the development of dosage forms. The interaction between drug and excipient will affect the chemical nature and bioavailability of the drug which may test the safety and efficacy of the drug. Present research work was done to study the compatibility between Torsemideand different pharmaceutical excipients like cross-povidone (CP) , magnesium stearate (MS) , microcrystalline cellulose (MCC) and Anhydrous lactose (AL) by different analytical techniques like FTIR(Fourier transf

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5

Tandel, D. B., P. A. Shah, K. G. Patel, M. C. Gohel, V. T. Thakkar, and T. R. Gandhi. "IMPROVEMENT OF DISSOLUTION RATE OF FEBUXOSTAT USING HYBRID TECHNIQUE OF SPHERICAL CRYSTALLIZATION AND SOLID DISPERSION." INDIAN DRUGS 52, no. 09 (2015): 32–39. http://dx.doi.org/10.53879/id.52.09.10274.

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The present study was carried out with an aim to improve dissolution rate of febuxostat (FBX, BCSclass II) drug. Spherical agglomerates were prepared by hybrid technique of spherical crystallization and solid dispersion using different ratios of FBX and polymer (PVP K30, HPMC E3LV and chitosan). Drug excipient compatibility study was evaluated by Fourier transform infrared spectroscopy and X-ray diffractometry. Scanning electron microscopy was used for measurement of size of agglomerate. In vitro dissolution study of prepared spherical agglomerates was compared with untreated FBX and marketed

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6

Mohamed, Amir Ibrahim, Amal Abd-Elaal El-Khamery, Mohamed Ismail Herry, and Alaa Ibrahim Mohamed. "Compatibility Determination of Drug-Polymer, Drug-Excipient & Drug-Intravenous Admixtures Using Chemometric-assisted UVspectrophotometry." Current Pharmaceutical Analysis 16, no. 2 (2020): 125–42. http://dx.doi.org/10.2174/1573412914666181011142351.

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Purpose: A new multivariate chemometric approach was developed for fast and economic compatibility determinations of ranitidine hydrochloride (as model drug) with certain pharmaceutical; polymers (Alginate & Chitosan), excipient (Lactose) and intravenous fluids (Dextrose, Ringer & Dextrose/ Ringer). Binary mixtures of the drug and each item were prepared and investigated by chemometric- assisted UV- spectrophotometry as well as by HPLC reference method. Methods: Five drug concentration levels (0.004-0.025mg/ml) of test-mixtures were used and the average drug recovery percent after two

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7

Tita, Ioana Cristina, Lavinia Lupa, Bogdan Tita, Roxana Liana Stan, and Laura Vicas. "Compatibility Studies of Valsartan with Different Pharmaceutical Excipients." Revista de Chimie 70, no. 7 (2019): 2590–600. http://dx.doi.org/10.37358/rc.19.7.7386.

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Compatibility studies between active drugs and excipients are substantial in the pharmaceutical technology. Thermal analysis has been extensively used to obtain information about drug-excipient interactions and to perform pre-formulation studies of pharmaceutical dosage forms. The objective of the present study was to evaluate the compatibility of the valsartan (VALS) with pharmaceutical excipients of common use including diluents, binders, disintegrants, lubricants and solubilising agents. Thermogravimetry (TG), derivative thermogravimetry (DTG), but especially differential scanning calorimet

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8

Wang, Nannan, Huimin Sun, Jie Dong, and Defang Ouyang. "PharmDE: A new expert system for drug-excipient compatibility evaluation." International Journal of Pharmaceutics 607 (September 2021): 120962. http://dx.doi.org/10.1016/j.ijpharm.2021.120962.

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9

Chadha, Renu, and Swati Bhandari. "Drug–excipient compatibility screening—Role of thermoanalytical and spectroscopic techniques." Journal of Pharmaceutical and Biomedical Analysis 87 (January 2014): 82–97. http://dx.doi.org/10.1016/j.jpba.2013.06.016.

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10

Chaves, Luíse L., Larissa A. Rolim, Maria L. C. M. Gonçalves, et al. "Study of stability and drug-excipient compatibility of diethylcarbamazine citrate." Journal of Thermal Analysis and Calorimetry 111, no. 3 (2012): 2179–86. http://dx.doi.org/10.1007/s10973-012-2775-7.

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11

Hamid, Junaid Ul, and Sunil Gupta. "Prediction of excipient-excipient incompatibility: A latent threat to pharmaceutical product development." Pharmaspire 14, no. 02 (2022): 65–75. http://dx.doi.org/10.56933/pharmaspire.2022.14208.

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The importance of pharmaceutical excipients in the creation of any dosage form is critical. These excipients are occasionally to blame for product underperformance and dosage form deterioration. Product deterioration and underperformance could be attributed to incompatibilities between drug and excipient or sometimes excipient and excipient either due to the presence of reactive impurities in the excipients or a reaction between the functional groups present on the excipients. Although the drug and excipient incompatibilities are monitored and reported, excipient-excipient incompatibilities ar

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12

Chaiya, Pornsit, and Thawatchai Phaechamud. "Differential Scanning Calorimetric Analysis for Incompatibility: Sodium Stearate/Magnesium Stearate and Acidic Compounds." Key Engineering Materials 859 (August 2020): 307–12. http://dx.doi.org/10.4028/www.scientific.net/kem.859.307.

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Compatibility investigation was performed between stearate lubricants (sodium stearate and magnesium stearate) and acidic pharmaceutical compounds (ibuprofen, indomethacin and valproic acid) and citric acid as acidic pharmaceutical excipient using differential scanning calorimetry (DSC). Alteration in DSC thermogram was found in all mixtures. There was a presence of melting endothermic peak of stearic acid in all mixtures (except that of stearate lubricants and indomethacin) indicating breakage of salt form of stearate lubricants depended on the physicochemical properties of drug compounds and

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13

Mohammed, Boma B., Adamu B. Isah, Teryilla S. Allagh, and Philip F. Builders. "Effects of a co-processed novel multifunctional excipient on the tablet properties of metronidazole." Journal of Science and Practice of Pharmacy 6, no. 1 (2019): 316–23. http://dx.doi.org/10.47227/jsppharm.v6i1.6.

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Purpose: The objective of this work was to formulate and determine the effects of a co-processed novel, multifunctional pharmaceutical excipient on tablet parameters of metronidazole tablets produced by direct compression. Methods: The excipient was prepared by co-processing lactose, mucin and gelatin in a ratio of 90:1:9, dried and pulverized into powder using the co-fusion method. The excipient formulated was characterized using Differential scanning calorimetry (DSC) and Fourier transform infra-red spectroscopy (FTIR). The excipient was used to prepare metronidazole tablets and compared wit

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14

Serajuddin, Abu T. M., Ajit B. Thakur, Rabin N. Ghoshal, et al. "Selection of solid dosage form composition through drug–excipient compatibility testing." Journal of Pharmaceutical Sciences 88, no. 7 (1999): 696–704. http://dx.doi.org/10.1021/js980434g.

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15

Thomas, V. Hayden, and Maryanne Naath. "Design and utilization of the drug–excipient chemical compatibility automated system." International Journal of Pharmaceutics 359, no. 1-2 (2008): 150–57. http://dx.doi.org/10.1016/j.ijpharm.2008.03.043.

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16

Maximiano, Flávia Pires, Kátia Monteiro Novack, Maria Terezinha Bahia, Lívia Lira de Sá-Barreto, and Marcílio Sérgio Soares da Cunha-Filho. "Polymorphic screen and drug–excipient compatibility studies of the antichagasic benznidazole." Journal of Thermal Analysis and Calorimetry 106, no. 3 (2011): 819–24. http://dx.doi.org/10.1007/s10973-011-1371-6.

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17

Schlich, Michele, Francesco Lai, Anna Maria Fadda, Chiara Sinico, and Elena Pini. "Drug-Excipients Compatibility Studies in Proniosomal Formulation: A Case Study with Resveratrol." Journal of Nanoscience and Nanotechnology 21, no. 5 (2021): 2917–21. http://dx.doi.org/10.1166/jnn.2021.19056.

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Proniosomal drug delivery system is one of the advancements in nanotechnology. Similarly to traditional dosage forms, chemical and physical compatibility of proniosomes components with the active ingredient(s) is a key step in the preformulation process of such systems. In this work, the compatibility of resveratrol with selected excipients in the development of proniosomal formulation was investigated by thermal and spectroscopic techniques. To evaluate the drug-excipient compatibility, different techniques such as differential scanning calorimetric study, attenuated total reflectance Fourier

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18

Rayakwar, Neetesh, and Yuvraj Singh Dangi. "Development and characterization of controlled release bilayered tablets of Citicoline sodium." Journal of Drug Delivery and Therapeutics 9, no. 2-s (2019): 125–31. http://dx.doi.org/10.22270/jddt.v9i2-s.2471.

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Objectives: The aim of present investigation was formulation development and evaluation of bi-layer tablets of citicoline sodium. Materials and Methods: An aqueous granulation process was adopted to formulate citicoline sodium (CTS) bilayer tablets. Wet granulation method has been utilized for the formulation of bilayer CTS tablet. Citicoline sodium, microcrystalline cellulose (pH 101 & 102), HPMC K4, K15, K-100, PVP K-30, Magnesium stearate, cross-carmellose sodium, sodium starch glycolate and red oxide were used for preparation. Pre-formulation studies of citicoline sodium and drug excip

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19

Dudhat, Ms Kiran Rameshbhai. "The Overview of Oral Solid Dosage Forms and Different Excipients Used for Solid Dosage Formulation." Global Academic Journal of Pharmacy and Drug Research 4, no. 3 (2022): 66–72. http://dx.doi.org/10.36348/gajpdr.2022.v04i03.003.

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When creating pharmaceutical dosage forms, the selection of excipients plays a significant role in the preformulation and formulation research. Excipients physical, mechanical, and chemical characteristics have a big impact on the final product and other formulation parameters like disintegration, dissolution, and shelf life. As a result, numerous studies have been carried out to assess how drug-excipient interactions affect the formulation as a whole. The information on excipients physical and chemical instability and compatibility with the active pharmaceutical component in solid oral dosage

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20

Savisa Yadav, Pooja Rani, Kumari Shanno, et al. "Development and characterization of Tinospora cordifolia extract-loaded SLNs for the treatment of autoimmune hepatitis." World Journal of Advanced Research and Reviews 20, no. 3 (2023): 1102–14. http://dx.doi.org/10.30574/wjarr.2023.20.3.2565.

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Solid Lipid Nanoparticles (SLNs) have emerged as promising drug delivery systems with the potential to enhance the therapeutic efficacy of bioactive compounds. In this study, T. Cordifolia extract-loaded SLNs were developed and characterized for their application in the treatment of autoimmune hepatitis. T. Cordifolia, known for its immunomodulatory and anti-inflammatory properties, was chosen as the active ingredient. The formulations were systematically evaluated for drug-excipient compatibility, particle size, zeta potential, drug loading efficiency, drug release kinetics, encapsulation eff

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21

Savisa, Yadav, Rani Pooja, Shanno Kumari, et al. "Development and characterization of Tinospora cordifolia extract-loaded SLNs for the treatment of autoimmune hepatitis." World Journal of Advanced Research and Reviews 20, no. 3 (2023): 1102–14. https://doi.org/10.5281/zenodo.12755037.

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Solid Lipid Nanoparticles (SLNs) have emerged as promising drug delivery systems with the potential to enhance the therapeutic efficacy of bioactive compounds. In this study, <em>T. Cordifolia</em> extract-loaded SLNs were developed and characterized for their application in the treatment of autoimmune hepatitis. <em>T. Cordifolia</em>, known for its immunomodulatory and anti-inflammatory properties, was chosen as the active ingredient. The formulations were systematically evaluated for drug-excipient compatibility, particle size, zeta potential, drug loading efficiency, drug re

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22

Li, Yu, Xiangwen Kong, and Fan Hu. "Crystal Transition and Drug-excipient Compatibility of Clarithromycin in Sustained Release Tablets." Current Pharmaceutical Analysis 16, no. 7 (2020): 950–59. http://dx.doi.org/10.2174/1573412915666190328234326.

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Background: Clarithromycin is widely used for infections of helicobacter pylori. Clarithromycin belongs to polymorphic drug. Crystalline state changes of clarithromycin in sustained release tablets were found. Objective: The aim of this study was to find the influential factor of the crystal transition of clarithromycin in preparation process of sustained-release tablets and to investigate the possible interactions between the clarithromycin and pharmaceutical excipients. Methods and Results: The crystal transition of active pharmaceuticals ingredients from form II to form I in portion in clar

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23

Wyttenbach, Nicole, Christian Birringer, Jochem Alsenz, and Martin Kuentz. "Drug-Excipient Compatibility Testing Using a High-Throughput Approach and Statistical Design." Pharmaceutical Development and Technology 10, no. 4 (2005): 499–505. http://dx.doi.org/10.1080/10837450500299875.

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24

Gao, Rui, Yi Jin, Qing-Yi Yang, Bai-Wang Sun, and Jun Lin. "Study of stability and drug-excipient compatibility of estradiol and pharmaceutical excipients." Journal of Thermal Analysis and Calorimetry 120, no. 1 (2014): 839–45. http://dx.doi.org/10.1007/s10973-014-4234-0.

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25

Balestrieri, Fabrizio, Andrea D. Magrì, Antonio L. Magrì, Domenico Marini, and Amalia Sacchini. "Application of differential scanning calorimetry to the study of drug-excipient compatibility." Thermochimica Acta 285, no. 2 (1996): 337–45. http://dx.doi.org/10.1016/0040-6031(96)02904-8.

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26

V, Kishan, Swathi Yambadi, and Ramesh Bomma. "Drug Excipient Compatibility, Development and Preliminary Clinical Studies of Tizanidine Hydrochloride Floating Drug Delivery System." International Journal of Pharmaceutical Sciences and Nanotechnology 14, no. 1 (2021): 5334–42. http://dx.doi.org/10.37285/ijpsn.2021.14.1.9.

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The objective of this investigation was to develop formulation of floating matrix tablets of tizanidine HCl to prolong the gastric residence time by using hydroxy propyl methyl cellulose (HPMC K15M) or xanthan gum as sole release retardant and to check the clinical response. The drug-excipients compatibility studies were conducted using DSC and also by visual observation. Incorporation of NaHCO3 in the formulation resulted incompatibility with drug and therefore, the composition was modified by replacing NaHCO3 with CaCO3 in remaining formulations. Floating matrix tablets of tizanidine were de

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27

Karishma, Singh, Mehrotra Archana, and Singh Sobhna. "Methods Development and Validation for the Estimation of Pioglitazone HCl in Bulk and Formulations by UV Spectroscopy and FTIR." UTTAR PRADESH JOURNAL OF ZOOLOGY 44, no. 22 (2023): 184–92. http://dx.doi.org/10.56557/upjoz/2023/v44i223732.

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The use of spectroscopic analysis, particularly UV spectrophotometer, is a simple and essential technique for bulk drug estimation, formulation studies, and compatibility assessments of drugs with various excipients. In the pharmaceutical industry, various analytical instruments, including Fourier transform infrared spectroscopy (FTIR), are employed for investigating drug-excipient interactions that can impact the stability of active pharmaceutical ingredients. This study aimed to develop a UV spectrophotometric method for the analysis of Pioglitazone hydrochloride in phosphate buffer (pH 7.4)

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28

Challa, Stalin. "Preparation And Invitro Evaluation of Nanocapsules by Using Tapentadol." Clinical and Medical Research and Studies 2, no. 3 (2023): 1–2. http://dx.doi.org/10.59468/2836-8525/027.

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The primary object of the current study is to form and evaluate tapentadole nano capsules. According to this study, polymers are used to prepare nano capsules by nanoprecipitation method. In this method ethyl cellulose as a key ingredient and Ethanol is used as solvent. Various formulations were produced by varying the ratios of ethyl cellulose and drug. The resulted formulations were evaluated for parameters like drug content, weight variation, invitro drug release and drug excipient compatibility, SEM, FTIR, DSC. In this method, the release profile highlydepends on concentration of polymer.

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29

Sharma, Shyam Bihari, Suman Jain, and K. Ganesan. "Preformulation Studies of Pralidoxime Chloride for Formulation Development of Microspheres." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 338–42. http://dx.doi.org/10.22270/jddt.v9i4-s.3336.

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Microspheres are one of the novel drug delivery system which possess several applications and are made up of assorted polymers. Microspheres can be defined as solid, approximately spherical particles ranging in size from 1 to 1000 μm range in diameter having a core of drug and entirely outer layers of polymers as coating material. They are made up of polymeric, waxy or other protective materials i.e. biodegradable synthetic polymer and modified natural products such as starches, gums, proteins, fats and waxes. Preformulation is a group of studies that focus on the physicochemical properties of

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30

Shalini, Chenna M., S. Anila, and Tadikonda Rama Rao. "Formulation and Evaluation of Bilayered Floating Tablets of Aceclofenac." Journal of Drug Delivery and Therapeutics 14, no. 8 (2024): 84–95. http://dx.doi.org/10.22270/jddt.v14i8.6738.

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The objective of this study was to create and assess homogeneous bilayered floating tablets of aceclofenac in order to increase the drug's bioavailability and prolong its stomach release. One of the nonsteroidal anti-inflammatory drugs (NSAID) common side effects is poor solubility and minimal stomach retention, which makes it difficult to treat effectively. As matrix-forming polymers, ten formulations (F1–F10) were made with different amounts of HPMC K15 and additional excipients. Physical properties, buoyancy, in vitro drug release, and kinetic modelling were evaluated for each formulation.

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31

Hamid, Junaid Ul, and Sunil Gupta. "Development and validation of a system for the prediction of excipient-excipient incompatibility using machine learning tools." Pharmaspire 14, no. 01 (2022): 18–27. http://dx.doi.org/10.56933/pharmaspire.2022.14103.

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The importance of pharmaceutical excipients in the creation of any dosage form is critical. These excipients are occasionally to blame for product underperformance and dosage form deterioration. Product deterioration and underperformance could be attributed to incompatibilities between drug and excipient or sometimes excipient and excipient either due to the presence of reactive impurities in the excipients or a reaction between the functional groups present on the excipients. Although, the drug and excipient incompatibilities are monitored and reported, excipient-excipient incompatibilities a

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32

Parasuramudu, Samudram, and N. Sai Gowthami. "Development and Evaluation of Controlled Release Matrix Microspheres of Doxazosin using HPMC and Carbopol." International Journal of Enhanced Research in Medicines & Dental Care 12, no. 07 (2025): 21–33. https://doi.org/10.55948/ijermdc.2025.0704.

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Objective: This study aims to develop and evaluate controlled release matrix microspheres of Doxazosin, a poorly water-soluble antihypertensive drug, to overcome limitations associated with conventional oral dosage forms, including fluctuating plasma levels and frequent dosing. Methods: Microspheres were formulated using Hydroxypropyl Methylcellulose (HPMC K15) and Carbopol via the emulsion solvent evaporation technique. A series of ten formulations were developed and characterized for drug entrapment efficiency, mean particle size, micromeritic properties, and in-vitro drug release. FTIR and

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33

Tiwari, Sandip Prasad, and Gali Vidyasagar. "Identification, Characterization and Drug-Excipient Compatibility of Diltiazem Hydrochloride by Physico-Chemical Techniques." UK Journal of Pharmaceutical Biosciences 2, no. 5 (2014): 49. http://dx.doi.org/10.20510/ukjpb/2/i5/91134.

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34

Wu, Yongmei, Mandar Dali, Abhishek Gupta, and Krishnaswamy Raghavan. "Understanding drug-excipient compatibility: Oxidation of compound A in a solid dosage form." Pharmaceutical Development and Technology 14, no. 5 (2009): 556–64. http://dx.doi.org/10.1080/10837450903182140.

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35

Pires, Felipe Q., Tamara Angelo, Joyce K. R. Silva, et al. "Use of mixture design in drug-excipient compatibility determinations: Thymol nanoparticles case study." Journal of Pharmaceutical and Biomedical Analysis 137 (April 2017): 196–203. http://dx.doi.org/10.1016/j.jpba.2017.01.037.

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36

Bruni, Giovanna, Vittorio Berbenni, Chiara Milanese, Alessandro Girella, and Amedeo Marini. "Drug-excipient compatibility studies in binary and ternary mixtures by physico-chemical techniques." Journal of Thermal Analysis and Calorimetry 102, no. 1 (2009): 193–201. http://dx.doi.org/10.1007/s10973-009-0382-z.

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37

Xiao, Yuxuan, Haiyu Zheng, Meng Du, and Zhe Zhang. "Investigation on the Potential Application of Na-Attapulgite as an Excipient in Domperidone Sustained-Release Tablets." Molecules 27, no. 23 (2022): 8266. http://dx.doi.org/10.3390/molecules27238266.

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In this study, Na-attapulgite was explored as an excipient to prepare domperidone sustained-release tablets and test them in accordance with United States Pharmacopoeia requirements. Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD) and differential scanning calorimetry (DSC) were employed to explore the compatibility between Na-attapulgite and domperidone. The XRD and DSC show no interaction between the drug and Na-attapulgite. The FTIR spectrum indicates a shift in the absorption of N-H in the drug molecule, which can be explained by the hydrogen bonding interact

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38

Shinkar, D. M., M. S. Alai, and R. B. Saudagar. "Formulation and Evaluation of Floating Mucoadhesive Tablet of Clopidogrel." International Journal of Current Pharmaceutical Review and Research 8, no. 4 (2017): 320–27. https://doi.org/10.5281/zenodo.12674964.

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The objective of the present study was to formulate and evaluate Floating Mucoadhesive tablets of Clopidogrel for thetreatment of antithrombotic and antiplatelet agent. Tablets were prepared by direct compression using directly compressiblepolymers such as HPMC K4M, and Carbopol 934 were evaluated for drug-excipient compatibility, density, buoyancy test,mucoadhesion force, swelling study, drug content and In-Vitro release profile. Sodium bicarbonate and citric acid wereused producing effervescent base for buoyancy of tablets. Analysis of drug release from tablet indicates drug release byzero o

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39

Vlad, Robert-Alexandru, Andrada Pintea, Cezara Pintea, et al. "Hydroxypropyl Methylcellulose—A Key Excipient in Pharmaceutical Drug Delivery Systems." Pharmaceutics 17, no. 6 (2025): 784. https://doi.org/10.3390/pharmaceutics17060784.

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Hydroxypropyl methylcellulose (Hypromellose, HPMC) is a well-known excipient used in the pharmaceutical and nutraceutical fields due to its versatile physicochemical properties. HPMC (derived from cellulose and obtained through etherification) varies in polymerization degree and viscosity, factors that both influence its functional applications. Usually, an increased polymerization degree implies a higher viscosity, depending also on the amount of polymer used. Hypromellose plays a crucial role in solid dosage forms, serving as a binder in the case of controlled-release tablets, a film-forming

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40

Jadi, Rajendra K., Divya J. Yadagiri, Mounika Kuchukuntla, Mounika Konatham, Mounika T. Gorle, and Vasudha Bakshi. "Development and Characterization of Sildenafil Citrate Oral Thin Films." International Journal of Pharmaceutical Sciences and Drug Research 13, no. 02 (2020): 147–51. http://dx.doi.org/10.25004/ijpsdr.2021.130205.

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The current work aimed to develop sildenafil citrate (SC) oral thin films. SC oral thin films (OTF) were prepared by solvent casting method. The ingredients include hydroxypropyl methylcellulose (HPMC), E4 (as film former), glycerol (as lubricating agent), polyethylene glycol 600 (as plasticizer), rose oil (as flavoring agent), and de-ionized water (as solvent). The SC-OTFs were successfully prepared by the solvent casting method. The drug excipient compatibility studies showed the absence of drug excipient interactions in fourier transform infrared spectroscopy (FTIR) spectra. All the prepare

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41

Sharma, Megha, Seema Kohli, and Abhisek Pal. "PREPARATION AND EVALUATION OF CONTROLLED RELEASE FLOATING MICROSPHERES OF REPAGLINIDE: OPTIMIZATION AND IN-VITRO STUDIES." Asian Journal of Pharmaceutical and Clinical Research 10, no. 3 (2017): 103. http://dx.doi.org/10.22159/ajpcr.2017.v10i3.15310.

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ABSTRACTObjective: To develop and evaluate floating microspheres of repaglinide (RG).Materials and Methods: RG loaded noneffervescent microspheres of different ratios of ethylcellulose (EC) and hydroxypropyl methylcellulose (HPMCK4M) were prepared using polyvinyl alcohol as emulsifier by solvent evaporation technique. Various process variables such as polymer ratio, stirringspeed, concentration of drug, and emulsifying agent were studied. Compatibility of drug and polymers was studied by Fourier-transform infraredspectroscopy (FTIR). Characterization, in-vitro evaluation, and kinetic studies w

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42

Varghese, Nina, and M. Komala. "Determining the Influence of Breadfruit Mucilage on the Disintegration and Dissolution of Losartan Fast-Dissolving Tablets." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 13, no. 03 (2023): 780–91. http://dx.doi.org/10.25258/ijddt.13.3.01.

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organoleptic characteristics, hydration, swelling capacity, and pasting temperature of breadfruit starch were determined. It was found that breadfruit starch exhibited partial solubility in warm water, a pH of 5.8, and good hydration and swelling capacities. Furthermore, a compatibility test using differential scanning calorimetry confirmed the compatibility of losartan and breadfruit starch. It was determined that the formulated losartan tablets were satisfactory in terms of flow properties as well as consistent drug content both before and after compression. Dissolution studies in-vitro show

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Verma, Rajan K., and Sanjay Garg. "Selection of excipients for extended release formulations of glipizide through drug–excipient compatibility testing." Journal of Pharmaceutical and Biomedical Analysis 38, no. 4 (2005): 633–44. http://dx.doi.org/10.1016/j.jpba.2005.02.026.

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Saatkamp, Rodrigo Henrique, Bruna Mattos Dos Santos, Mariele Paludetto Sanches, et al. "Drug-excipient compatibility studies in formulation development: A case study with benznidazole and monoglycerides." Journal of Pharmaceutical and Biomedical Analysis 235 (October 2023): 115634. http://dx.doi.org/10.1016/j.jpba.2023.115634.

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Aslam, Aysha, Muhammad Umer Ashraf, Kashif Barkat, et al. "Fabrication of Stimuli-Responsive Quince/Mucin Co-Poly (Methacrylate) Hydrogel Matrices for the Controlled Delivery of Acyclovir Sodium: Design, Characterization and Toxicity Evaluation." Pharmaceutics 15, no. 2 (2023): 650. http://dx.doi.org/10.3390/pharmaceutics15020650.

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Free-radical polymerization technique was adopted to fabricate a stimuli-responsive intelligent quince/mucin co-poly (methacrylate) hydrogel for the controlled delivery of acyclovir sodium. The developed hydrogel matrices were appraised using different parameters, such as drug loading (%), swelling kinetics, pH- and electrolyte-responsive swelling, and sol–gel fraction. Drug-excipient compatibility study, scanning electron microscopy, thermal analysis, powder X-ray diffraction (PXRD) analysis, in vitro drug release studies, drug release kinetics and acute oral toxicity studies were conducted.

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Enéas, Paula Cristina Rezende, Renata Barbosa de Oliveira, and Gerson Antônio Pianetti. "Oxcarbazepine: validation and application of an analytical method." Brazilian Journal of Pharmaceutical Sciences 46, no. 2 (2010): 265–72. http://dx.doi.org/10.1590/s1984-82502010000200013.

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Oxcarbazepine (OXC) is an important anticonvulsant and mood stabilizing drug. A pharmacopoeial monograph for OXC is not yet available and therefore the development and validation of a new analytical method for quantification of this drug is essential. In the present study, a UV spectrophotometric method for the determination of OXC was developed. The various parameters, such as linearity, precision, accuracy and specificity, were studied according to International Conference on Harmonization Guidelines. Batches of 150 mg OXC capsules were prepared and analyzed using the validated UV method. Th

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Miskan, Risha, S. M. Shahidulla, and Sana Sultana. "Revolutionizing Drug Delivery: Nicardipine Nanosuspension Formulation and In-Vitro Evaluation." Journal of Drug Delivery and Therapeutics 13, no. 12 (2023): 137–47. http://dx.doi.org/10.22270/jddt.v13i12.6134.

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Nicardipine hydrochloride, is a potent calcium channel blocker, is commonly used in the management of hypertension and angina. It is a BCS class II drug which has low aqueous solubility and high permeability. In the present study, an attempt was made to formulate and evaluate nanosuspension of Nicardipine hydrochloride using different stabilizers, namely Tween 80, PVP K30, Poloxamer 188 by using Nanoprecipitation method with the objective to improve solubility and enhance dissolution of Nicardipine hydrochloride. Prepared nanosuspensions were evaluated for drug-excipient compatibility, particl

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Pakhale, Nilesh V., S. B. Gondkar, and R. B. Saudagar. "Formulation Development and Evalua Tion of Fluoxetine Effervescent Floating Tablet." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 358–66. http://dx.doi.org/10.22270/jddt.v9i4-a.3490.

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The objective of the present study was to formulate and evaluate Effervescent Floating Tablet of Fluoxetine for the treatment of antidepressant agent. Tablets were prepared by direct compression using directly compressible polymers such as HPMC K4M, and Carbopol 934 were evaluated for drug-excipient compatibility, density, buoyancy test, swelling study, drug content and In-Vitro release profile. Sodium bicarbonate and citric acid were used producing effervescent base for buoyancy of tablets. Analysis of drug release from tablet indicates drug release by zero order, first order rate kinetics. N

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Mounika, P., P. Vishnu, and Abbulu Konde. "Development and characterization of self micro emulsifying drug delivery system of rosavastatin." GSC Biological and Pharmaceutical Sciences 3, no. 1 (2018): 001–10. https://doi.org/10.5281/zenodo.4307465.

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The present study was undertaken to enhance solubility and dissolution rate of rosuvastatin by formulating it as a self -micro emulsifying drug delivery system (SMEDDS). The SMEDDS were prepared by using castor oil and sesame oil as oils, Tween 80 as surfactant and PEG 200 as co-surfactant. The prepared SMEDDS were further evaluated for drug content, thermodynamic stability and <em>in vitro</em> drug release. Among all the formulations the drug release for F2 formulation was 99.70% in 120 min. So it was considered as the optimized formulation. The selected optimized F2 formulation wa

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Pani, Nihar, Lila Nath, and Sujata Acharya. "Compatibility studies of nateglinide with excipients in immediate release tablets." Acta Pharmaceutica 61, no. 2 (2011): 237–47. http://dx.doi.org/10.2478/v10007-011-0016-4.

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Compatibility studies of nateglinide with excipients in immediate release tabletsExperiments were done to assess the compatibility of nateglinide with selected excipients in the development of immediate release tablets of nateglinide by thermal and isothermal stress testing (IST) techniques. To evaluate the drug-excipient compatibility, different techniques such as differential scanning calorimetric (DSC) study, infra-red (IR) spectrophotometric study and isothermal stress testing were adopted. The results of DSC study showed that magnesium stearate exhibited some interaction with nateglinide.

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