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Journal articles on the topic 'Drug-receptor interaction'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Al-Qaaneh, Ayman. "Effect of antibiotics' electromagnetic spectrums on the bacterial growths: beyond drug-receptor interaction." Journal of Medical pharmaceutical and allied sciences 12, no. 6 (2023): 6241–46. http://dx.doi.org/10.55522/jmpas.v12i6.5904.

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Electromagnetic frequencies (EF) generated from different laboratory devices and appliances can interact with biological systems, including humans. Several studies have assessed the effect of electromagnetic frequencies on the growth of microorganisms, which revealed that EF could inhibit bacterial growth, decrease colony-forming units, or decrease viability depending on the field strength and frequency. Accordingly, in this study, we aimed to assess the effect of the antibiotics extracted electromagnetic spectrums on the growth of Staphylococcus aureus (S. aureus). Drugs digital electromagnet

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2

Kenakin, Kenakin T. "Pharmacologic Analysis of Drug Receptor Interaction." Therapeutic Drug Monitoring 10, no. 3 (1988): 365–66. http://dx.doi.org/10.1097/00007691-198803000-00029.

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3

Neidle, Stephen. "Molecular foundations of drug-receptor interaction." FEBS Letters 233, no. 1 (1988): 215. http://dx.doi.org/10.1016/0014-5793(88)81394-2.

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4

Netter, K. J. "Pharmacologic analysis of drug-receptor interaction." Toxicology 93, no. 2-3 (1994): 301–2. http://dx.doi.org/10.1016/0300-483x(94)90086-8.

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5

Gago, Federico. "Molecular foundations of drug-receptor interaction." Journal of Molecular Graphics 5, no. 4 (1987): 223. http://dx.doi.org/10.1016/0263-7855(87)80032-2.

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6

Leff, Paul. "Pharmacologie analysis of drug-receptor interaction." Trends in Pharmacological Sciences 8, no. 12 (1987): 516–17. http://dx.doi.org/10.1016/0165-6147(87)90052-6.

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7

Short, Angela L. "Pharmacologic analysis of drug-receptor interaction." Toxicology Letters 78, no. 1 (1995): 83. http://dx.doi.org/10.1016/0378-4274(95)90240-6.

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8

Kietzmann, M. "Pharmacological analysis of drug-receptor interaction." Toxicon 32, no. 3 (1994): 377. http://dx.doi.org/10.1016/0041-0101(94)90098-1.

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9

Muzammil, Mahreen, and Syed Saad Hussain. "Drug-Drug Interaction between Non-Steroidal Anti-Inflammatory and Angiotensin Receptor Blocker." National Journal of Health Sciences 6, no. 2 (2022): 88–89. http://dx.doi.org/10.21089/njhs.62.0088.

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Abstract: Objective: In pharmacotherapy, factors such as mode of administration, dose, and contraindications play a significant part in determining the optimal pharmacotherapeutic strategy. A drug’s ability to influence the safety or efficacy of another drug (drug-drug interaction) is another factor to consider when choosing the best pharmacotherapy [1]. When multiple medications are prescribed at the same time, they may interact [2]. Drug-drug interactions (DDIs) can have a variety of outcomes, and adverse DDIs might result in patient death or drug withdrawal. Drug interactions can alter the

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10

Gupta, Satya Prakash. "Roles of Fluorine in Drug Design and Drug Action." Letters in Drug Design & Discovery 16, no. 10 (2019): 1089–109. http://dx.doi.org/10.2174/1570180816666190130154726.

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The article discusses the basic properties of fluorine atom that have made it so useful in drug development. It presents several examples of therapeutically useful drugs acting against many life-threatening diseases along with the mechanism as to how fluorine influences the drug activity. It has been pointed out that fluorine, due to its ability to increase the lipophilicity of the molecule, greatly affects the hydrophobic interaction between the drug molecule and the receptor. Because of its small size, it hardly produces any steric effect, rather due to electronic properties enters into elec

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11

Raffa, Robert B. "(Extra)thermodynamics of the drug-receptor interaction." Life Sciences 65, no. 10 (1999): 967–80. http://dx.doi.org/10.1016/s0024-3205(99)00197-6.

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12

Raffa, Robert B., and Frank Porreca. "Thermodynamic analysis of the drug-receptor interaction." Life Sciences 44, no. 4 (1989): 245–58. http://dx.doi.org/10.1016/0024-3205(89)90182-3.

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13

Juan, S. Gómez-Jeria, and Olarte-Lezcano Lilian. "On the relationships between electronic structure and 5-HT2A, 5-HT2C and D2 receptor affinities in a group of 2-aryl tryptamines. A DFT study." Chemistry Research Journal 7, no. 4 (2022): 14–35. https://doi.org/10.5281/zenodo.11402838.

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<strong>Abstract </strong>2-aryl tryptamines, hallucinogens, serotonin 5-HT<sub>2A</sub> receptor, serotonin 5-HT<sub>2C</sub> receptor, dopamine D<sub>2</sub> receptor, Klopman-Peradejordi-Gómez method, QSAR, receptor affinity, drug-receptor interaction, KPG method, alkyl interactions, hydrogen bond formation, MO-MO interactions.

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14

Kubica, Jacek. "Opioids and oral P2Y12 receptor inhibitors: A drug–drug interaction." Cardiology Journal 29, no. 5 (2022): 727–29. http://dx.doi.org/10.5603/cj.2022.0082.

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15

Sumartin, Yunita, and Elin Yulinah Sukandar. "STUDI INTERAKSI OBAT-OBAT JANTUNG YANG DILAKUKAN TERHADAP ORANG SEHAT: TINJAUAN SISTEMATIS." Kartika : Jurnal Ilmiah Farmasi 9, no. 2 (2024): 128–46. http://dx.doi.org/10.26874/kjif.v9i2.669.

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Pasien dengan penyakit kardiovaskular memiliki prevalensi interaksi obat yang lebih tinggi dibandingkan kelompok pasien lain karena jumlah dan penggunaan obat yang komplek. Interaksi obat merupakan perubahan efek kerja dari suatu obat karena adanya obat lain ketika diberikan bersamaan. Jenis interaksi obat terdiri dari interaksi farmakokinetik, farmakodinamik, dan farmasetik. Studi ini berupa tinjauan sistematis yang bertujuan untuk mengidentifikasi interaksi obat yang berkaitan dengan obat-obat jantung. Proses penelusuran artikel dilakukan pada database PubMed dan ScienceDirect untuk mengiden

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16

Vernier, P. "An evolutionary view of drug-receptor interaction: the bioamine receptor family." Trends in Pharmacological Sciences 16, no. 11 (1995): 375–81. http://dx.doi.org/10.1016/s0165-6147(00)89078-1.

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17

Singh, R. K., and Mohd Adil Khan. "Interaction energy-based drug-receptor interaction study of metal-bicyclam complexes." International Journal of Quantum Chemistry 111, no. 15 (2011): 4174–85. http://dx.doi.org/10.1002/qua.22983.

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18

Sahu, Vishnu Kumar, Neetu Chandra, Anil Kumar Soni, Pratibha Singh, and Rajesh Kumar Singh. "Drug-Receptor Interaction of Peptidic HIV-1 Protease: Intermolecular Interaction-III." Online Journal of Microbiological Research 3, no. 1 (2023): 1–22. http://dx.doi.org/10.31586/ojmr.2023.630.

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19

Colquhoun, David. "Pharmacologic Analysis of Drug–Receptor Interaction (3rd edn)." Trends in Pharmacological Sciences 19, no. 12 (1998): 515–16. http://dx.doi.org/10.1016/s0165-6147(98)01235-8.

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20

de Barros, Yuri Yabu, Amanda A. Carneiro, Simone Batista Pires Sinoti, et al. "Herbal-drug interaction through the pregnane X receptor." Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas 22, no. 3 (2023): 326–38. http://dx.doi.org/10.37360/blacpma.23.22.3.24.

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The interaction potential of Cynara scolymusL.,Mikania glomerataSpreng.,Rhamnus purshianaDC and Uncaria tomentosa(Willd. Ex Roem. & Schult.) with conventional drugs metabolized by the CYP3A4 metabolic route was tested in HeLa cell lines, using the in vitromodel of the hPXR. The herbal medicines C. scolymus(1.5 mg/mL dry extract) did not affect the receptor. On the other hand, M. glomerata(5.5 mg/mL dry extract), R. purshiana(1.5 mg/mL dry extract), and U. tomentosa(2.0 mg/mL dry extract) showed to be hPXR agonist, suggesting a potential interaction with the conventional drugs metabolized b

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21

Cui, Zhijie, Hong Kang, Kailin Tang, Qi Liu, Zhiwei Cao, and Ruixin Zhu. "Screening Ingredients from Herbs against Pregnane X Receptor in the Study of Inductive Herb-Drug Interactions: Combining Pharmacophore and Docking-Based Rank Aggregation." BioMed Research International 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/657159.

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The issue of herb-drug interactions has been widely reported. Herbal ingredients can activate nuclear receptors and further induce the gene expression alteration of drug-metabolizing enzyme and/or transporter. Therefore, the herb-drug interaction will happen when the herbs and drugs are coadministered. This kind of interaction is called inductive herb-drug interactions. Pregnane X Receptor (PXR) and drug-metabolizing target genes are involved in most of inductive herb-drug interactions. To predict this kind of herb-drug interaction, the protocol could be simplified to only screen agonists of P

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22

Skoutakis, Vasilios A. "Comparison of the Parenteral Histamine2-Receptor Antagonists." DICP 23, no. 10_suppl (1989): S17—S22. http://dx.doi.org/10.1177/1060028089023s1003.

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The chemical structure, pharmacokinetic properties, and drug–drug interaction profiles of the parenterally available histamine2 (H2)-receptor antagonists were compared. Famotidine is a guanidinothiazole derivative, ranitidine contains an aminomethylfuran ring, and cimetidine has an imidazole ring. Data from the literature indicate that because of its chemical structure famotidine has a much greater potency and affinity for the H2-receptor and a notable lack of drug–drug interactions when compared with ranitidine and cimetidine. As a result, famotidine should be considered the H2-receptor antag

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23

Bohl, Martin, та Manfred Wunderwald. "Molecular Mechanics Investigation on Conformational Flexibility of 14β Steroids in Drug-Receptor Interactions". Zeitschrift für Naturforschung C 41, № 3 (1986): 297–300. http://dx.doi.org/10.1515/znc-1986-0309.

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The interaction between two 14 β steroids being still unsynthesized and a model receptor binding site is theoretically studied by a molecular mechanics scheme. Both com pounds containing seven-membered rings in the 17 β position are found to form stable hydrogen bonds to the receptor and can be attributed to be potential inhibitors of the Na +,K + -ATPase activity. Substantial steroid conformational changes necessary for an efficient receptor binding are calculated to reduce the interaction energy by only 10 kJ mol -1. Therefore, alterations in steroid structure should be generally taken into

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24

Piedade, Rita, Stefanie Traub, Andreas Bitter, et al. "Carboxymefloquine, the Major Metabolite of the Antimalarial Drug Mefloquine, Induces Drug-Metabolizing Enzyme and Transporter Expression by Activation of Pregnane X Receptor." Antimicrobial Agents and Chemotherapy 59, no. 1 (2014): 96–104. http://dx.doi.org/10.1128/aac.04140-14.

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ABSTRACTMalaria patients are frequently coinfected with HIV and mycobacteria causing tuberculosis, which increases the use of coadministered drugs and thereby enhances the risk of pharmacokinetic drug-drug interactions. Activation of the pregnane X receptor (PXR) by xenobiotics, which include many drugs, induces drug metabolism and transport, thereby resulting in possible attenuation or loss of the therapeutic responses to the drugs being coadministered. While several artemisinin-type antimalarial drugs have been shown to activate PXR, data on nonartemisinin-type antimalarials are still missin

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25

Millan-Casarrubias, Elmer Joel, Yunia Verónica García-Tejeda, Claudia Haydée González-De la Rosa, Lucero Ruiz-Mazón, Yazmín Mariela Hernández-Rodríguez, and Oscar Eduardo Cigarroa-Mayorga. "Molecular Docking and Pharmacological In Silico Evaluation of Camptothecin and Related Ligands as Promising HER2-Targeted Therapies for Breast Cancer." Current Issues in Molecular Biology 47, no. 3 (2025): 193. https://doi.org/10.3390/cimb47030193.

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Breast cancer is one of the leading causes of cancer-related mortality in women worldwide, highlighting the importance of effective therapies. This study evaluates the interaction between camptothecin, a potent anticancer agent, and two key receptors implicated in breast cancer progression: HER2 (human epidermal growth factor receptor 2) and EGFR (epidermal growth factor receptor), using molecular docking. The results reveal a stronger binding affinity between camptothecin and HER2 than EGFR, in contrast to neratinib, which demonstrated affinity exclusively for HER2. Camptothecin exhibits sign

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26

Hasnita, Hasnita, Farit Mochamad Afendi, and Anwar Fitrianto. "PERBANDINGAN BEBERAPA METODE KLASIFIKASI DALAM MEMPREDIKSI INTERAKSI FARMAKODINAMIK." Indonesian Journal of Statistics and Its Applications 4, no. 1 (2020): 11–21. http://dx.doi.org/10.29244/ijsa.v4i1.328.

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One mechanism for Drug-Drug Interaction (DDI) is pharmacodynamic (PD) interactions. They are interactions by which the effects of a drug are changed by other drugs at the site of receptor. The interactions can be predicted based on Side Effects Similarity (SES), Chemical Similarity (CS) and Target Protein Connectedness (TPC). This study aims to find the best classification technique by first applying the scaling process, variable interaction, discretization and resampling technique. We used Random Forest, Support Vector Machines (SVM) and Binary Logistic Regression for the classification. Out

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27

Kabbani, Nadine, Mathew P. Woll, Jacob C. Nordman, and Robert Levenson. "Dopamine Receptor Interacting Proteins: Targeting Neuronal Calcium Sensor-1/D2 Dopamine Receptor Interaction for Antipsychotic Drug Development." Current Drug Targets 13, no. 1 (2012): 72–79. http://dx.doi.org/10.2174/138945012798868515.

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28

Mohd Hatta, Muhammad Najmi Munawwar, and Normala Abd Latip. "Comprehensive Review of CYP2B6 Transcriptional Modulators, Variants, and Their Role in Drug Interactions." Biomedical and Pharmacology Journal 18, no. 2 (2025): 1191–207. https://doi.org/10.13005/bpj/3162.

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Cytochrome P450 2B6 (CYP2B6) plays a significant role in the metabolism of various drugs, yet its regulation and clinical relevance are often underappreciated. Numerous substrates of CYP2B6 have been identified to date, and these findings may contribute to potential drug-drug interactions in patients. Extensive research has been conducted to assess how drugs affect the activity of CYP2B6 and, consequently, impact therapy effectiveness in patients. These investigations are crucial for establishing safe drug dosages for patients. The objective of this review is to offer insights into the drug-dr

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Hossain, Md Jamal, Md Shamiul Islam, Saimon Shahriar, et al. "COMEDICATION OF RABEPRAZOLE SODIUM CAUSES POTENTIAL DRUG-DRUG INTERACTION WITH DIABETIC DRUG LINAGLIPTIN: In-vitro AND In-silico APPROACHES." Journal of Experimental Biology and Agricultural Sciences 9, no. 4 (2021): 528–42. http://dx.doi.org/10.18006/2021.9(4).528.542.

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Drug-drug interaction is a notable concern among physicians when prescribing multi-therapy to the patients as concomitant administration of multi-drugs might cause unexpected adverse drug reactions. The main objective of this research is to predict a potential drug-drug interaction between two frequently used drugs by diabetic patients, an antidiabetic drug (linagliptin) and a proton pump inhibitor (rabeprazole sodium). Here, several in vitro techniques, including thermal (melting point, thermogravimetric analysis [TGA]), morphological (scanning electron microscopy [SEM] and X-ray powder diffr

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Egieyeh, Samuel, Elizabeth Egieyeh, Sarel Malan, Alan Christofells, and Burtram Fielding. "Computational drug repurposing strategy predicted peptide-based drugs that can potentially inhibit the interaction of SARS-CoV-2 spike protein with its target (humanACE2)." PLOS ONE 16, no. 1 (2021): e0245258. http://dx.doi.org/10.1371/journal.pone.0245258.

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Drug repurposing for COVID-19 has several potential benefits including shorter development time, reduced costs and regulatory support for faster time to market for treatment that can alleviate the current pandemic. The current study used molecular docking, molecular dynamics and protein-protein interaction simulations to predict drugs from the Drug Bank that can bind to the SARS-CoV-2 spike protein interacting surface on the human angiotensin-converting enzyme 2 (hACE2) receptor. The study predicted a number of peptide-based drugs, including Sar9 Met (O2)11-Substance P and BV2, that might bind

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Egieyeh, Samuel, Elizabeth Egieyeh, Sarel Malan, Alan Christofells, and Burtram Fielding. "Computational drug repurposing strategy predicted peptide-based drugs that can potentially inhibit the interaction of SARS-CoV-2 spike protein with its target (humanACE2)." PLOS ONE 16, no. 1 (2021): e0245258. http://dx.doi.org/10.1371/journal.pone.0245258.

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Drug repurposing for COVID-19 has several potential benefits including shorter development time, reduced costs and regulatory support for faster time to market for treatment that can alleviate the current pandemic. The current study used molecular docking, molecular dynamics and protein-protein interaction simulations to predict drugs from the Drug Bank that can bind to the SARS-CoV-2 spike protein interacting surface on the human angiotensin-converting enzyme 2 (hACE2) receptor. The study predicted a number of peptide-based drugs, including Sar9 Met (O2)11-Substance P and BV2, that might bind

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32

Botts, Sheila R., and Cara Alfaro. "Antidepressant Drug Interactions." Journal of Pharmacy Practice 14, no. 6 (2001): 467–77. http://dx.doi.org/10.1177/089719001129040964.

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Second-generation antidepressants are more selective in their pharmacological mechanisms and offer fewer side effects and a safer toxicological profile than cyclic antidepressants and monoamine oxidase inhibitors. While the risk for pharmacodynamic interactions is more limited than with older agents with broader receptor effects, the risks for pharmacokinetic interactions is greater. The capacity of selective serotonin reuptake inhibitors to inhibit the metabolic activity of cytochrome P450 isozyme system has spurred over a decade of intense psychopharmacological and pharmacogenetics research

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Gonçalves, Sónia, and Nuno C. Santos. "Membrane–Peptide Interactions: From Basics to Current Applications 2.0." International Journal of Molecular Sciences 24, no. 8 (2023): 7202. http://dx.doi.org/10.3390/ijms24087202.

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The interaction between peptides and biological membranes is of fundamental importance in the mechanism of numerous membrane-mediated cellular processes, including antimicrobial peptide action, hormone–receptor interactions, drug bioavailability across the blood–brain barrier, and viral fusion processes [...]

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34

Patil, Prajakta, Mrunal Desai, Gayathri Baburaj, et al. "Optimizing Cardiovascular Treatment in Non-Small Cell Lung Cancer: A Comprehensive Computational Approach for Assessment of Drug-Drug Interactions between Tyrosine Kinase Inhibitors and Cardiovascular Drugs." F1000Research 14 (March 19, 2025): 309. https://doi.org/10.12688/f1000research.162353.1.

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Background As lung cancer treatment has progressed, there has been an increase in awareness of the short- and long-term adverse effects of targeted cancer therapies of tyrosine kinase inhibitors, particularly cardiovascular toxicities. Methods The current study assessed the potential drug interactions using interaction drug-interaction checkers (IBM Micromedex and Drugs.com). Molecular docking was employed to further investigate the involvement of human ether-à-go-go-related gene (hERG) and pregnane X receptor (PXR) proteins to elucidate their potential interactions and underlying mechanisms.

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35

Basak, Subhash C., and Lemont B. Kier. "Editorial: Delving into the Fundamental Aspects of Drug-Receptor Interaction." Current Computer-Aided Drug Design 13, no. 2 (2017): 87–88. http://dx.doi.org/10.2174/157340991302170418214357.

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36

Fang, Ye. "Ligand–receptor interaction platforms and their applications for drug discovery." Expert Opinion on Drug Discovery 7, no. 10 (2012): 969–88. http://dx.doi.org/10.1517/17460441.2012.715631.

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37

Dayan, A. D. "Book Reviews: Pharmacologic Analysis of Drug-Receptor Interaction Terry Kenakin." Human & Experimental Toxicology 13, no. 8 (1994): 579. http://dx.doi.org/10.1177/096032719401300816.

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38

Sahu, V. K., A. K. R. Khan, R. K. Singh, and P. P. Singh. "Drug-receptor interaction-based quantitative structure-activity relationship of tetrahydroimidazodiazepinone." International Journal of Quantum Chemistry 109, no. 6 (2009): 1243–54. http://dx.doi.org/10.1002/qua.21942.

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39

Kuthuru, Srikanth, Adam T. Szafran, Fabio Stossi, Michael A. Mancini, and Arvind Rao. "Leveraging Image-Derived Phenotypic Measurements for Drug-Target Interaction Predictions." Cancer Informatics 18 (January 2019): 117693511985659. http://dx.doi.org/10.1177/1176935119856595.

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In recent years, protein kinases have become some of the most significant drug targets in cancer patients. Kinases are known to regulate the activity of many human proteins, and consequently their inhibition has been used to control cancer proliferation. A significant challenge in drug discovery is the rapid and efficient identification of new small molecules. In this study, we propose a novel in silico drug discovery approach to identify kinase targets that impinge on nuclear receptor signaling with data generated using high-content analysis (HCA). A high-throughput imaging dataset was genera

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40

Pan, Xian, Cong Liu, Felix Stader, Abdallah Derbalah, Masoud Jamei, and Iain Gardner. "Mechanistic Insights into Cytokine Antagonist-Drug Interactions: A Physiologically Based Pharmacokinetic Modelling Approach with Tocilizumab as a Case Study." Pharmaceutics 17, no. 7 (2025): 896. https://doi.org/10.3390/pharmaceutics17070896.

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Background: Understanding interactions between cytokine antagonists and drugs is essential for effective medication management in inflammatory conditions. Recent regulatory authority guidelines emphasise a systematic, risk-based approach to evaluating these interactions, underscoring the need for mechanistic insight. Proinflammatory cytokines, such as interleukin-6 (IL-6), modulate cytochrome P450 (CYP) enzymes, reducing the metabolism of CYP substrates. Cytokine antagonists (such as IL-6 receptor antagonists) can counteract this effect, restoring CYP activity and increasing drug clearance. Ho

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Filip, M., M. Zaniewska, M. Frankowska, K. Wydra, and K. Fuxe. "The Importance of the Adenosine A2A Receptor-Dopamine D2 Receptor Interaction in Drug Addiction." Current Medicinal Chemistry 19, no. 3 (2012): 317–55. http://dx.doi.org/10.2174/092986712803414231.

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Gnerre, Carmela, Jérôme Segrestaa, Swen Seeland, et al. "The metabolism and drug–drug interaction potential of the selective prostacyclin receptor agonist selexipag." Xenobiotica 48, no. 7 (2017): 704–19. http://dx.doi.org/10.1080/00498254.2017.1357088.

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Chadwick, Ben, Derek G. Waller, and J. Guy Edwards. "Potentially hazardous drug interactions with psychotropics." Advances in Psychiatric Treatment 11, no. 6 (2005): 440–49. http://dx.doi.org/10.1192/apt.11.6.440.

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Of the many interactions with psychotropic drugs, a minority are potentially hazardous. Most interactions are pharmacodynamic, resulting from augmented or antagonistic actions at a receptor or from different mechanisms in the same tissue. Most important pharmacokinetic interactions are due to effects on metabolism or renal excretion. The major enzymes involved in metabolism belong to the cytochrome P450 (CYP) system. Genetic variation in the CYP system produces people who are ‘poor’, ‘extensive’ or ‘ultra-rapid’ drug metabolisers. Hazardous interactions more often result from enzyme inhibition

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Gaikwad, Nikita Maruti, Pravin Digambar Chaudhari, Karimunnisa Sameer Shaikh, et al. "Albendazole repurposing on VEGFR-2 for possible anticancer application: In-silico analysis." PLOS ONE 18, no. 8 (2023): e0287198. http://dx.doi.org/10.1371/journal.pone.0287198.

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Drug repurposing is the finding new activity of the existing drug. Recently, Albendazole’s well-known antihelmintic has got the attention of an anticancer drug. Plausible evidence of the interaction of Albendazole with one of the types of tyrosine kinase protein receptor, vascular endothelial growth factor receptor-2 (VEGFR-2) is still not well understood. Inhibition of the VEGFR-2 receptor can prevent tumor growth. The current study investigated the interaction of Albendazole with VEGFR-2.It was found that the said interaction exhibited potent binding energy ΔG = -7.12 kcal/mol, inhibitory co

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Sangita and Ray S. "Impact of chirality on drug action." Journal of Indian Chemical Society Vol. 83, Apr 2006 (2006): 315–26. https://doi.org/10.5281/zenodo.5835662.

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Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow-226 001, Uttar Pradesh Indta E-mail : suprabhatray @yahoo.co.in <em>Manuscript received 30 December 2004. revised 26 September 2005, accepted 28 December 2005</em> The biological activity of a drug molecule is usually initiated through its interaction with receptors. The effect induced by the drug depends upon the affinity of the drug molecule for its specific receptor.For chiral receptors such rureceptor proteins, the chirality of the interacting molecule plays a major role in defining biological activity towards affini

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Brody, Gene H., Yi-Fu Chen, Tianyi Yu, et al. "Life stress, the dopamine receptor gene, and emerging adult drug use trajectories: A longitudinal, multilevel, mediated moderation analysis." Development and Psychopathology 24, no. 3 (2012): 941–51. http://dx.doi.org/10.1017/s0954579412000466.

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AbstractThis study was designed to examine the prospective relations of life stress and genetic status with increases in drug use. African Americans (N = 399) in rural Georgia (Wave 1 mean age = 17 years) provided three waves of data across 27.5 months and a saliva sample from which the dopamine receptor D4 (DRD4) gene was genotyped. Multilevel growth curve modeling analysis indicated that emerging adults manifested the highest escalations in drug use when they reported high life stress and carried an allele of DRD4 with 7 or more repeats (7 + R allele). In addition, emerging adults who report

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Veeramachaneni, Thunuguntla, Bhaswant, Mathai, and Bondili. "Pharmacophore Directed Screening of Agonistic Natural Molecules Showing Affinity to 5HT2C Receptor." Biomolecules 9, no. 10 (2019): 556. http://dx.doi.org/10.3390/biom9100556.

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Obesity prevalence continues to be a foremost health concern across the globe leading to the development of major health risk conditions like type II diabetes, hyperlipidemia, hypertension and even cancers. Because of the deprived drug-based management system, there is an urgent need for the development of new drugs aiming at satiety and appetite control targets. Among the reported satiety signaling targets, 5HT2C receptor plays a crucial role in decreasing appetite and has become a promising target for the development of anti-obesity drugs. Lorcaserin, a 5HT2C receptor agonist and the only dr

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Queirós-Reis, Luís, Rui Alvites, Ana Colette Maurício, Andrea Brancale, Marcella Bassetto, and João R. Mesquita. "Disrupting SARS-CoV-2 Spike Protein Activity: A Virtual Screening and Binding Assay Study." International Journal of Molecular Sciences 26, no. 1 (2024): 151. https://doi.org/10.3390/ijms26010151.

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Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a respiratory virus that emerged in late 2019 and rapidly spread worldwide, causing the COVID-19 pandemic. The spike glycoprotein (S protein) plays a crucial role in viral target recognition and entry by interacting with angiotensin, converting enzyme 2 (ACE2), the functional receptor for the virus, via its receptor binding domain (RBD). The RBD availability for this interaction can be influenced by external factors, such as fatty acids. Linoleic acid (LA), a free fatty acid, has been shown to bind the S protein, modulating the vi

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Fan, Hushuai, Xiaomin Huang, Ziru Zhang, Ting Wang, Ludan Wang, and Yajun Zhang. "Immobilization of M3 Muscarinic Receptor to Rapidly Analyze Drug—Protein Interactions and Bioactive Components in a Natural Plant." International Journal of Molecular Sciences 24, no. 8 (2023): 7171. http://dx.doi.org/10.3390/ijms24087171.

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Despite its increasing application in pursing potential ligands, the capacity of receptor affinity chromatography is greatly challenged as most current research studies lack a comprehensive characterization of the ligand–receptor interaction, particularly when simultaneously determining their binding thermodynamics and kinetics. This work developed an immobilized M3 muscarinic receptor (M3R) affinity column by fixing M3R on amino polystyrene microspheres via the interaction of a 6-chlorohexanoic acid linker with haloalkane dehalogenase. The efficiency of the immobilized M3R was tested by chara

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Occhipinti, Mario, Marta Brambilla, Giulia Galli, et al. "Evaluation of Drug—Drug Interactions in EGFR-Mutated Non-Small-Cell Lung Cancer Patients during Treatment with Tyrosine-Kinase Inhibitors." Journal of Personalized Medicine 11, no. 5 (2021): 424. http://dx.doi.org/10.3390/jpm11050424.

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(1) Background. The onset of a drug–drug interaction (DDI) may affect treatment efficacy and toxicity of advanced non-small-cell lung cancer (aNSCLC) patients during epidermal growth factor receptor (EGFR) tyrosine-kinase inhibitor (TKI) use. Here we present the use of Drug-PIN® (Personalized Interactions Network) software to detect DDIs in aNSCLC patients undergoing EGFR-TKIs. (2) Methods. We enrolled patients with Stage IV aNSCLC already treated with or candidates to receive EGFR-TKIs, in any line; ECOG PS 0–2; taking at least one concomitant drug. Cancer treatments, concomitant drugs, and c

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