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Journal articles on the topic 'Drug solution'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Shurshina, Anzhela, Roman Lazdin, Elena Zakharova, Anastasiya Titlova, and Elena Kulish. "Prolonging effect of polyvinyl alcohol on the drug release." Chimica Techno Acta 9, no. 2 (2022): 20229206. http://dx.doi.org/10.15826/chimtech.2022.9.2.06.

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Polymers are currently of interest as drug delivery systems. The use of polymeric forms of medicinal substances will eliminate or reduce the disadvantages of traditional drugs. The purpose of this work was to assess the ability to prolong the action of polyvinyl alcohol in relation to the drug release when going from dilute to more concentrated solutions. It was established that an increase in the viscosity of the polymer in solution caused by an increase in its concentration results not only in a slowdown in the diffusion of drugs from the polymer solution, but also in a significant decrease

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2

Scanga, Lisa. "Drug Problem: Environmental Solution." Pace Environmental Law Review 22, no. 1 (2005): 151. http://dx.doi.org/10.58948/0738-6206.1139.

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3

De Vin, Filip, Peter Rutherford, and Dirk Faict. "Intraperitoneal Administration of Drugs in Peritoneal Dialysis Patients: A Review of Compatibility and Guidance for Clinical Use." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 29, no. 1 (2009): 5–15. http://dx.doi.org/10.1177/089686080902900101.

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Peritoneal dialysis (PD) is an effective home-based therapy for end-stage renal failure. Intraperitoneal administration of drugs to PD patients is particularly important for the treatment of peritonitis. Clinicians need to know that the administered drug is compatible with both the PD solution and its container. A detailed literature search on drug compatibility and stability was performed and results of all published stability studies are presented for all drugs, PD solutions, and containers studied. These data will aid clinicians managing PD patients and provide a resource to demonstrate whi

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4

Odeh, Afnan Bany, Boushra El-Sayed, Matthias Manne Knopp, Thomas Rades, and Lasse Ingerslev Blaabjerg. "Influence of Polyvinylpyrrolidone Molecular Weight and Concentration on the Precipitation Inhibition of Supersaturated Solutions of Poorly Soluble Drugs." Pharmaceutics 15, no. 6 (2023): 1601. http://dx.doi.org/10.3390/pharmaceutics15061601.

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Supersaturating drug delivery systems such as solid dispersions of a drug in a polymer are frequently used in pharmaceutical development to enable oral delivery of poorly soluble drugs. In this study, the influence of the concentration and molecular weight of polyvinylpyrrolidone (PVP) on the precipitation inhibition of the poorly soluble drugs albendazole, ketoconazole and tadalafil is investigated to expand the understanding of the mechanism of PVP as a polymeric precipitation inhibitor. A three-level full-factorial design was used to delineate the influence of polymer concentration and visc

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5

Shi, Li, and Naixia Zhang. "Applications of Solution NMR in Drug Discovery." Molecules 26, no. 3 (2021): 576. http://dx.doi.org/10.3390/molecules26030576.

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During the past decades, solution nuclear magnetic resonance (NMR) spectroscopy has demonstrated itself as a promising tool in drug discovery. Especially, fragment-based drug discovery (FBDD) has benefited a lot from the NMR development. Multiple candidate compounds and FDA-approved drugs derived from FBDD have been developed with the assistance of NMR techniques. NMR has broad applications in different stages of the FBDD process, which includes fragment library construction, hit generation and validation, hit-to-lead optimization and working mechanism elucidation, etc. In this manuscript, we

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6

Chen, Pin, Xin Wang, Yan Dong, and Xiaohong Hu. "Development of a Layer-by-Layer Assembled Film on Hydrogel for Ocular Drug Delivery." International Journal of Polymer Science 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/535092.

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Hydrogel is a kind of attractive drug carriers because of its good biocompatibility and transparency. But traditional hydrogel showed some restrictions in its application in ocular drug delivery. A simple surface modification technique based on layer-by-layer (LbL) self-assembled multilayer for ocular drug delivery was developed in this work. Polycarboxymethyl-β-cyclodextrin (poly(CM-β-CD))/poly-l-lysine (PLL) multilayer film was designed and constructed for ocular drug delivery, sinceβ-CD showed good drug delivery property. The properties such as the contact angle and transparency varied a li

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7

Potts, Keagan. "A Solution to the Hard Problem of Soft Law." Michigan Journal of Environmental & Administrative Law, no. 10.2 (2021): 483. http://dx.doi.org/10.36640/mjeal.10.2.solution.

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Administrative Agencies often rely on guidance documents to carry out their statutory mandate. Over the past few decades, the Food and Drug Administration (FDA) has been criticized for using soft law guidance documents to exercise powers beyond those authorized by Congress. Since attacks on the use of guidance documents persist and agencies need soft law to respond quickly and flexibly to rapid technological growth, it is essential to develop a solution that preserves this crucial regulatory mechanism and prevents its abuse. The most likely alternative to soft law guidance is formal regulation

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8

Walicka, A., and B. Iwanowska-Chomiak. "Drug Diffusion Transport Through Human Skin." International Journal of Applied Mechanics and Engineering 23, no. 4 (2018): 977–88. http://dx.doi.org/10.2478/ijame-2018-0055.

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Abstract The stratum corneum (SC) forms the outermost layer of the human skin and is essentially a multilamellar lipid milieu punctuated by protein-filled corneocytes that augment membrane integrity and significantly increase membrane tortuosity. The lipophilic character of the SC, coupled with its intrinsic tortuosity, ensure that it almost always provides the principal barrier to the entry of drug molecules into the organism. Drugs can be administered either as suspensions or as solutions and the formulation can range in complexity from a gel or and ointment to a multilayer transdermal path.

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9

Almakaeva, LG, LG Naumenok, NV Begunova, VG Dolya, and MS Almakaev. "DEVELOPMENT OF DOMESTIC INFUSION DRUGS BASED ON PARACETAMOL." Annals of Mechnikov Institute, no. 2 (November 18, 2016): 65–68. https://doi.org/10.5281/zenodo.167497.

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The intravenous form of paracetamol compared with oral more reliably supports effective drug concentration in blood plasma that promotes a higher therapeutic effect. Recent studies have confirmed that the use of the intravenous form of paracetamol to deal with postoperative pain multimodal analgesia modes results in reducing the frequency and quantity of opioids administered , and, as a consequence, its associated side effects. The drug Paracetamol , infusion solution 10 mg / ml to 100 ml glass bottles is a drug - generic . His qualitative and quantitative composition is developed from the stu

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10

Gomez-Sanchez, Ruben, Stephen Besley, Zoe Zeliku, and Robert J. Young. "Method Development and Application of an Accelerated Solution Stability Screen for Drug Discovery." SLAS DISCOVERY: Advancing the Science of Drug Discovery 25, no. 10 (2020): 1191–96. http://dx.doi.org/10.1177/2472555220931795.

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An important aspect to understand about an experimental molecule in drug discovery is its stability in solution. A compound that degrades might be eliciting its apparent effect via a degradation product, so it is important to understand the solution stability profile of a compound early on in the drug discovery process. Improvements and application of a streamlined, higher-throughput method for testing solution stability to support drug discovery are described. Mass spectrometry detection has been incorporated into the screen to allow for the identification of degradation products. The amount

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11

Sibinovska, Nadica, Simon Žakelj, Jurij Trontelj, and Katja Kristan. "Applicability of RPMI 2650 and Calu-3 Cell Models for Evaluation of Nasal Formulations." Pharmaceutics 14, no. 2 (2022): 369. http://dx.doi.org/10.3390/pharmaceutics14020369.

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The RPMI 2650 and Calu-3 cell lines have been previously evaluated as models of the nasal and airway epithelial barrier, and they have demonstrated the potential to be used in drug permeation studies. However, limited data exist on the utilization of these two cell models for the assessment of nasal formulations. In our study, we tested these cell lines for the evaluation of in vitro permeation of intranasally administered drugs having a local and systemic effect from different solution- and suspension-based formulations to observe how the effects of formulations reflect on the measured in vit

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12

Satir, Aylin, Miriam Pfiffner, Christoph R. Meier, and Angela Caduff Good. "Use of unlicensed drugs in a Swiss Pediatric University Hospital and associated prescribing error rates – a retrospective observational study." Swiss Medical Weekly 154, no. 3 (2024): 3369. http://dx.doi.org/10.57187/s.3369.

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AIMS OF THE STUDY: Unlicensed drugs are frequently used in paediatric care. To what extent they are prescribed in hospital care in Switzerland is unclear. Because prescribing errors seem to occur more frequently with unlicensed drugs, we aimed to assess the prevalence of unlicensed drug prescriptions in two study periods (2018 and 2019) at the University Children’s Hospital Zurich, compare these periods and investigate whether unlicensed drugs were more prone to prescribing errors than licensed drugs. METHODS: We conducted a sub-analysis of a retrospective single-centre observational study and

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13

Tamam, Hassan, Jelan Abdel-Aleem, Sayed Abdelrahman, Aly Abdelrahman, and Yoon Yeo. "ENHANCEMENT OF LIPOSOMAL DRUG LOADING BY USING SUPERSATURATED DRUG SOLUTION." Bulletin of Pharmaceutical Sciences. Assiut 42, no. 1 (2019): 31–38. http://dx.doi.org/10.21608/bfsa.2019.62263.

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14

Kennedy, D. "Drug Prices: Real Problem, Wrong Solution." Science 292, no. 5523 (2001): 1797. http://dx.doi.org/10.1126/science.292.5523.1797.

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15

Veesler, Stéphane, Laurent Lafferrère, Eric Garcia, and Christian Hoff. "Phase Transitions in Supersaturated Drug Solution." Organic Process Research & Development 7, no. 6 (2003): 983–89. http://dx.doi.org/10.1021/op034089f.

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16

Tuma, Rabiya S. "Drug designers seek a structural solution." Drug Discovery Today 8, no. 22 (2003): 1012. http://dx.doi.org/10.1016/s1359-6446(03)02906-4.

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17

Naplekov, D. K., E. T. Zhilyakova, A. Yu Malyutina, et al. "New Approach to Drug Delivery in Ophthalmological Practice: Development of Composite Ophthalmological Solution for Drug Loading of Soft Contact Lenses." Drug development & registration 9, no. 4 (2020): 59–64. http://dx.doi.org/10.33380/2305-2066-2020-9-4-59-64.

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Introduction. This article provides a tentative justification of use of soft contact lenses as a carrier of ophthalmological solutions to eye tissues.Aim. The aim of the research is to develop the composition of the ophthalmic transport system for the treatment of glaucoma. Also, the proposed manufacturing algorithms were proposed for drug loading ophthalmological solutions.Materials and methods. Preparation of sodium hyaluronate solution was carried out based on the methodology described in EP 7.0 [01/2011:1472] (Sodium hyaluronate).Results and discussion. The conducted investigation with the

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18

Rao, Linjie, and Xinrong Lyu. "Research Progress of Paclitaxel Drug Source Solution and Extraction and Separation Technology." BIO Web of Conferences 124 (2024): 01004. http://dx.doi.org/10.1051/bioconf/202412401004.

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Taxol, a natural secondary metabolite extracted from the bark of taxus chinensis, is one of the best natural anti-tumor drugs in the past decade and has great medicinal value. However, the content of paclitaxel in plant body is low, the extraction and separation are difficult, and the drug source is short. Based on the review of the literature on paclitaxel, this paper discusses and reviews the solutions of paclitaxel’s drug sources in terms of its synthesis, plant cell culture, endophytic fungi fermentation and synthetic biology. The research progress of paclitaxel extraction and separation t

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19

Mau, Robert, and Hermann Seitz. "Influence of the Volatility of Solvent on the Reproducibility of Droplet Formation in Pharmaceutical Inkjet Printing." Pharmaceutics 15, no. 2 (2023): 367. http://dx.doi.org/10.3390/pharmaceutics15020367.

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Drop-on-demand (DOD) inkjet printing enables exact dispensing and positioning of single droplets in the picoliter range. In this study, we investigate the long-term reproducibility of droplet formation of piezoelectric inkjet printed drug solutions using solvents with different volatilities. We found inkjet printability of EtOH/ASA drug solutions is limited, as there is a rapid forming of drug deposits on the nozzle of the printhead because of fast solvent evaporation. Droplet formation of c = 100 g/L EtOH/ASA solution was affected after only a few seconds by little drug deposits, whereas for

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20

Song, Ji Eun, Seung-Hyun Jun, Sun-Gyoo Park, and Nae-Gyu Kang. "A Semi-Dissolving Microneedle Patch Incorporating TEMPO-Oxidized Bacterial Cellulose Nanofibers for Enhanced Transdermal Delivery." Polymers 12, no. 9 (2020): 1873. http://dx.doi.org/10.3390/polym12091873.

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Although dissolving microneedles have garnered considerable attention as transdermal delivery tools, insufficient drug loading remains a challenge owing to their small dimension. Herein, we report a one-step process of synthesizing semi-dissolving microneedle (SDMN) patches that enable effective transdermal drug delivery without loading drugs themselves by introducing TEMPO-oxidized bacterial cellulose nanofibers (TOBCNs), which are well dispersed, while retaining their unique properties in the aqueous phase. The SDMN patch fabricated by the micro-molding of a TOBCN/hydrophilic biopolymer mixt

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21

Matencio, Adrián, Gjylije Hoti, Yousef Monfared, et al. "Cyclodextrin Monomers and Polymers for Drug Activity Enhancement." Polymers 13, no. 11 (2021): 1684. http://dx.doi.org/10.3390/polym13111684.

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Cyclodextrins (CDs) and cyclodextrin (CD)-based polymers are well-known complexing agents. One of their distinctive features is to increase the quantity of a drug in a solution or improve its delivery. However, in certain instances, the activity of the solutions is increased not only due to the increase of the drug dose but also due to the drug complexation. Based on numerous studies reviewed, the drug appeared more active in a complex form. This review aims to summarize the performance of CDs and CD-based polymers as activity enhancers. Accordingly, the review is divided into two parts, i.e.,

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22

Khaydarov, V. R., N. S. Fayzullaeva, F. Kh Maksudova, and Sh B. Yusupova. "OPTIMIZATION OF THE TECHNOLOGY OF “PHOSFARGININE SUCCINATE” INFUSION SOLUTION." American Journal of Applied Sciences 04, no. 11 (2022): 09–23. http://dx.doi.org/10.37547/tajas/volume04issue11-02.

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In recent years, much attention has been paid to providing the population with domestically produced pharmaceuticals, the production of new import-substituting drugs that are affordable from an economic point of view, important tasks have been identified for “the development of the pharmaceutical industry, as well as improving the provision of the population and medical institutions with cheap, high-quality drugs”. In this regard, the search for new drugs, their introduction into the pharmaceutical industry is being carried out. One of these drugs is "Phosfarginine succinate" (consisting of D-

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23

GARSHASBI, M., and H. KAMAL GHARIBI. "NUMERICAL INVESTIGATION OF THE RELEASE OF DRUG FROM A DRUG-DELIVERY DEVICE." International Journal of Modern Physics: Conference Series 09 (January 2012): 119–26. http://dx.doi.org/10.1142/s201019451200517x.

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In this study a mathematical model for the release of drug from porous, nonswelling transdermal drug-delivery devices to a perfect sink is considered. The drug is postulated to diffuse in both the solvent-filled pores and the body of the polymer. The limit in which the dissolution of drug is the dominant process is considered and a moving boundary problem governing drug release is derived. This model is solved numerically under some spacial conditions. Furthermore, another limit case in which the dissolution process is not so rapid is investigated and analytical and numerical solutions based o

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Wawro, Dariusz, Andrzej Bodek, and Kazimiera Henryka Bodek. "Starch Film as a Carrier of a Model Drug Substance from the Group of Non-Steroidal Anti-Inflammatory Drugs." Fibres and Textiles in Eastern Europe 26, no. 6(132) (2018): 102–13. http://dx.doi.org/10.5604/01.3001.0012.5166.

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The article describes the production of starch film as a carrier of a model drug substance from the group of non-steroidal anti-inflammatory drugs (NSAIDs). An analgesic/anti- inflammatory drug was put into aqueous starch solution, and next a film was formed. The following solid drug substances were included in the tests: acetylsalicylic acid, salicylic acid, ibuprofen lysine salt, naproxen in the form of acid, and sodium salt. Solutions were obtained from ibuprofen lysine salt and naproxen sodium, whereas the other drugs enabled to obtain aqueous suspensions. Such a drug substance was mixed w

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Naureen, Faiza, Yasar Shah, Shahnaz, and Fazli Khuda. "Determination of Saturated Solubility of Mirtazapine Using UV Visible Spectrophotometer." Pharmaceutical Communications 3, no. 01 (2024): 27–34. https://doi.org/10.55627/pharma.003.001.0799.

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Solubility is an important parameter for designing new drug formulations. Many drugs possess poor aqueous solubility hence, poor bioavailability. Many pharmaceutical industries face these issues while designing new drug entities. A new assessment revealed that about 70–90% of drug candidates are in the development stage, while up to 40% of the marketed products are water-insoluble which leads to low bioavailability, reduced therapeutic effects, and increased dose. Poor solubility is one of the major driving forces behind the development of numerous new drugs. There are various techniques to en

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Romanenko, О., Т. Tkachuk, and B. Blyshchyk. "Ultraviolet radiation treatment of the drug «KENO CID 210»." Energy and Automation, no. 4 (September 23, 2020): 116–21. http://dx.doi.org/10.31548/energiya2020.04.116.

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The effectiveness of the process of photoactivation of aqueous solutions has been proven by studies conducted in the article. As a method of exposure, UV radiation is low-cost and natural, so there is a need to study the effect of ultraviolet radiation on aqueous disinfectant solutions and to determine effective methods of irradiation. Accordingly, there is a need to investigate the effect of UV radiation on disinfectants, in particular on their antimicrobial properties and to determine the effective effect of ultraviolet radiation on the tool. The high pressure mercury arc lamp DRT-400 lamp w

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Bhakti, Ms Kharat, Ms Kumbhar Sneha, Ms Khatal Dhanashri, et al. "A Review on: Herbal Thin Film Forming Solution." International Journal of Pharmaceutical Research and Applications 09, no. 05 (2024): 1098–107. https://doi.org/10.35629/4494-090510981107.

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The strength of any Partial formulation deepens effective level. This limitation can be overcome by development of enhanced bioavailability and better stability of phyto constituents the better therapeutic effect Several novel herbal delivery systems have been successfully developed Topical film forming system is novel approach for treatment of skin diseases give both topical and transdermal treatment, FFS is defined a non-solid doses form which produces film in situ i.e., on the evaporation of vehicle excipients in the formulations form film on skin. Skin is considered as an important route o

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Han, Ling, Yingbo Ma, Hao Dou, and Wei Fan. "Dual-functional SFP/PAN based nano drug release system for treatment and nutrients." Textile Research Journal 91, no. 15-16 (2021): 1742–51. http://dx.doi.org/10.1177/0040517520988094.

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Nano drug delivery systems can control the ordered release of drugs. To achieve the target of supplying therapeutics and nutrients at the same time, a novel nano drug delivery system with a core–shell structure was prepared by coaxial electrospinning. Polyacrylonitrile (PAN) has been used to produce a drug release scaffold in the shell section, mixed with absorbable silk fibroin peptide (SFP) as a nutrient. Ciprofloxacin (CPFX), a broad-spectrum antibiotic, was used as the core, as well as an antibacterial agent. Owing to its low molecular weight, using a pure SFP thin solution to manufacture

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Pedro, Sónia N., Maria S. M. Mendes, Bruno M. Neves, et al. "Deep Eutectic Solvent Formulations and Alginate-Based Hydrogels as a New Partnership for the Transdermal Administration of Anti-Inflammatory Drugs." Pharmaceutics 14, no. 4 (2022): 827. http://dx.doi.org/10.3390/pharmaceutics14040827.

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The transdermal administration of nonsteroidal anti-inflammatory drugs (NSAIDs) is a valuable and safer alternative to their oral intake. However, most of these drugs display low water solubility, which makes their incorporation into hydrophilic biopolymeric drug-delivery systems difficult. To overcome this drawback, aqueous solutions of bio-based deep eutectic solvents (DES) were investigated to enhance the solubility of ibuprofen, a widely used NSAID, leading to an increase in its solubility of up to 7917-fold when compared to its water solubility. These DES solutions were shown to be non-to

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30

Urakov, Alexander L. "Method and technology for drug repurposing based on changes in the physicochemical properties of dosage forms: experience of use in Russia." Psychopharmacology & biological narcology 14, no. 3 (2023): 203–8. http://dx.doi.org/10.17816/phbn567970.

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Controlled local hyperthermia and hypothermia are important factors in drug pharmacodynamics and pharmacokinetics because changing the temperature of drugs changes their physicochemical properties. In this regard, a controlled change in the temperature of the drug and/or the body part with which the drug interacts, relative to the level of human body temperature (hyperthermia or hypothermia) forms the basis of temperature pharmacology. To analyze the authors publications on the problem of methodology and technology for repurposing drugs based on changes in the physicochemical properties of dos

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Kamolov, Imomali H., Dzhamil A. Asadov, Tamara S. Sandodze, and Irina E. Chernysheva. "Microporous surface as a new solution for stent surface modification: A review." Consilium Medicum 24, no. 10 (2022): 718–25. http://dx.doi.org/10.26442/20751753.2022.10.201955.

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The introduction of coronary stents into clinical practice has reduced repeated patient visits compared with balloon angioplasty alone. Also, drug-eluting stents substantially reduced the restenosis incidence. Therefore, later complications related to the implantation of a stent coated with a cytostatic-containing polymer became more relevant. The mechanism of late stent complications is multifactorial. It is mainly due to the body's response to the prolonged indwelling of the drug carrier polymer on the coronary stent's surface. There is a trend towards the return of polymer-free drug coating

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Miriyala, Nikhila, Daniel J. Kirby, Aude Cumont, et al. "Synthesis of Carbon Onion and Its Application as a Porous Carrier for Amorphous Drug Delivery." Crystals 10, no. 4 (2020): 281. http://dx.doi.org/10.3390/cryst10040281.

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Given the great potential of porous carrier-based drug delivery for stabilising the amorphous form of drugs and enhancing dissolution profiles, this work is focussed on the synthesis and application of carbon onion or onion-like carbon (OLC) as a porous carrier for oral amorphous drug delivery, using paracetamol (PA) and ibuprofen (IBU) as model drugs. Annealing of nanodiamonds at 1100 °C produced OLC with a diamond core that exhibited low cytotoxicity on Caco-2 cells. Solution adsorption followed by centrifugation was used for drug loading and results indicated that the initial concentration

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Kulkarni, Ajit S., Nagesh H. Aloorkar, Madhav S. Mane, and Jayashree B. Gaja. "Liquisolid Systems: A Review." International Journal of Pharmaceutical Sciences and Nanotechnology 3, no. 1 (2010): 795–802. http://dx.doi.org/10.37285/ijpsn.2010.3.1.1.

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Liquisolid technique is a new and promising method that can change the dissolution rate of water insoluble drugs. According to the new formulation method of liquisolid compacts, liquid medications such as solutions or suspensions of water insoluble drugs in suitable non-volatile liquid vehicles can be converted into acceptably flowing and compressible powders by blending with selected powder excipients. It has been speculated that such systems exhibit enhanced release profiles. In this case, even though the drug is in a solid dosage form, it is held within the powder substrate in solution or,

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Goel, R., M. Mangal, A. Sharma, P. Kumar та A. Gupta. "Exploring Self-Assembled Cationic Nanostructures of Amphiphilic β-Peptides for Amplifying Drug Delivery Efficiency". Asian Journal of Chemistry 35, № 12 (2023): 3093–104. http://dx.doi.org/10.14233/ajchem.2023.30738.

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In this study, a set of short sequences of amphiphilic peptides composed of synthetic amino acids β-alanine and ornithine were designed. The synthesis of these peptides was carried out in a solution phase and then self-assembled into cationic nanostructures. The formation of cationic nanostructures was confirmed using dynamic light scattering (DLS) and the morphology of the nanostructures was studied using transmission electron microscopy (TEM), which revealed that the nanostructure adopted a spherical shape. To gain insight into the conformation of both solid samples and peptide solutions, th

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35

Sikarra, Deepshikha. "TECHNIQUES FOR SOLUBILITY ENHANCEMENT OF POORLY SOLUBLE DRUGS: AN OVERVIEW." Journal of Medical Pharmaceutical and Allied Sciences 1, no. 1 (2012): 4–11. http://dx.doi.org/10.55522/jmpas.v1i1.0002.

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A success of formulation depends on how efficiently it makes the drug available at the site of action. Solubility is the phenomenon of dissolution of solid in liquid phase to give a homogenous system. There are many techniques which are used to enhance the aqueous solubility. The ability to increase aqueous solubility can thus be a valuable aid to increasing efficiency and/or reducing side effects for drugs. This is true for parenterally, topically and orally administered solutions. Hence various techniques are used for the improvement of the solubility of poorly water soluble drugs include hy

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36

Budiman, Arif, Zahra Ganesya Citraloka, Muchtaridi Muchtaridi, Sriwidodo Sriwidodo, Diah Lia Aulifa, and Agus Rusdin. "Inhibition of Crystal Nucleation and Growth in Aqueous Drug Solutions: Impact of Different Polymers on the Supersaturation Profiles of Amorphous Drugs—The Case of Alpha-Mangostin." Pharmaceutics 14, no. 11 (2022): 2386. http://dx.doi.org/10.3390/pharmaceutics14112386.

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The polymer used in supersaturated solutions plays a critical role in maintaining supersaturation levels of amorphous drugs. The prevention of drug crystallization in the supersaturated solutions by adding polymers depends on their ability to inhibit nucleation and crystal growth of drugs. This showed that understanding the mechanism of nucleation inhibition by polymers is necessary to develop the drug formulation in supersaturated solutions. Therefore, this study aims to evaluate the impact of water-soluble polymers on the supersaturation behavior of drugs and elucidate the mechanism of maint

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Sornsuvit, Chuleegone, Purida Wientong, Suriyon Uitrakul, Siriporn Okonogi, and Wasan Katip. "Influence of Concentration and Temperature on Stability of Imipenem Focused on Solutions for Extended Infusion." Dose-Response 19, no. 4 (2021): 155932582110593. http://dx.doi.org/10.1177/15593258211059325.

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Background Imipenem remains active against most Gram-positive and Gram-negative organisms. This study aimed to evaluate chemical stability of imipenem in 2 commonly used concentrations when stored in 3 various temperatures. Methods Imipenem injection powder was used to prepare 5 mL and 10 mg/mL of imipenem in .9% sodium chloride solution. Prepared solutions in PVC bags were stored at 25°C, 30°C, and 40°C. The solutions were investigated over 0, 1, 2, 3, 4, and 6 hours using HPLC analysis. The association between drug stability, temperature, and concentration was determined. Results The 5 mg/mL

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Rohit Ambare, Rohit Ambare, Dhanshri Khatal Dhanshri Khatal, Sneha Kumbhar Sneha Kumbhar, et al. "Formulation and Evaluation of Potato extract Herbal thin film forming solution." International Journal of Pharmaceutical Research and Applications 10, no. 2 (2025): 2164–74. https://doi.org/10.35629/4494-100221642174.

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The escalating demand for enhanced therapeutic efficacy and reduced adverse effect & in pharmaceutical domain has catalyzed frontier of innovation and research. The D nekl in the field of pharmacy. Novel drug delivery system Drug delivery methods known as topical film forming systems” are administered topically. Adhere to the body and create a delicate transparent film that carries active components to body tissue. Topical film forming systems. Are such developing drug delivery systems ment for topical application to the skin, which adhere to the body, forming a thin transparent film and p

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Le, Mengqi, Wen Huang, Kai-Feng Chen, et al. "Upper critical solution temperature polymeric drug carriers." Chemical Engineering Journal 432 (March 2022): 134354. http://dx.doi.org/10.1016/j.cej.2021.134354.

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Harding, Margaret M., Georgina V. Long, and Christopher L. Brown. "Solution conformation of the antitumor drug streptonigrin." Journal of Medicinal Chemistry 36, no. 21 (1993): 3056–60. http://dx.doi.org/10.1021/jm00073a003.

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Barcon, Douglas L., Cary A. Presant, and Jean Melville. "Purging procedure eliminates antineoplastic drug solution spillage." American Journal of Health-System Pharmacy 44, no. 10 (1987): 2254. http://dx.doi.org/10.1093/ajhp/44.10.2254.

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Leed, Alison, Kateri DuBay, Lyann M. B. Ursos, Devin Sears, Angel C. de Dios, and Paul D. Roepe. "Solution Structures of Antimalarial Drug−Heme Complexes†." Biochemistry 41, no. 32 (2002): 10245–55. http://dx.doi.org/10.1021/bi020195i.

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Ulery, B. D. "SNAPPy solution for fighting drug-resistant bacteria." Science Translational Medicine 8, no. 360 (2016): 360ec164. http://dx.doi.org/10.1126/scitranslmed.aai9161.

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Wasiullah, Prof (Dr )Mohd, Prof (Dr )Piyush Yadav, Mohit Vishwakarma, and Masheera Tasleem. "A Universal Solution for Monitoring Drug Safety." International Journal of Pharmaceutical Research and Applications 10, no. 2 (2025): 2730–38. https://doi.org/10.35629/4494-100227302738.

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This review article provides a comprehensive overview of pharmacovigilance, a crucial discipline that ensures the safety and efficacy of medications. Pharmacovigilance involves the detection, assessment, understanding, and prevention of adverse effects or other drug-related problems. The article discusses the history and development of pharmacovigilance, its scope, functions, and importance in public health. It also highlights the challenges and future trends in pharmacovigilance, including the adoption of artificial intelligence and machine learning, patient engagement, and the use of real-wo

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K, Tiwari. "Drug Resistance: Challenges and Updates." Journal of Natural & Ayurvedic Medicine 3, no. 3 (2019): 1–2. http://dx.doi.org/10.23880/jonam-16000196.

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Use of antibiotics increased dramatically in last two decades. To cure most of the diseases broad spectrum antibiotics given. Human society and healthcare is going in wrong direction. One way the pharmaceutical companies are making huge money from it. The other way around is the overuse of these antibiotics, by patients knowing or unknowingly, not only making pathogens adapted but also the normal flora organisms becoming pathogens in coming future? Present article highlight the issues and possible solution of the present scenario.

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Maheswari, Karra. "Identifying Side Effects of Adverse Drug Reactions via Drug-Drug Interactions with Advanced Neural Network Techniques." International Journal for Research in Applied Science and Engineering Technology 13, no. 4 (2025): 914–20. https://doi.org/10.22214/ijraset.2025.68392.

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Abstract: Adverse Drug Reactions (ADRs) due to drug-drug interactions pose a significant public health issue, impacting mortality, morbidity, and healthcare costs. The increasing complexity of therapeutics and aging populations intensify these challenges. Currently, no standard method exists to detect such ADRs before drugs reach the market, as rare interactions often emerge only after patient reports. Clinical trials struggle to capture these rare effects. Thus, a reliable technique to predict ADRs prior to drug release is urgently needed. We propose an effective framework that models drug-dr

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Sudi Mungkasi. "Modelling And Simulation of Topical Drug Diffusion in The Dermal Layer of Human Body." Journal of Advanced Research in Fluid Mechanics and Thermal Sciences 86, no. 2 (2021): 39–49. http://dx.doi.org/10.37934/arfmts.86.2.3949.

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We consider the problem of drug diffusion in the dermal layer of human body. Two existing mathematical models of the drug diffusion problem are recalled. We obtain that the existing models lead to inconsistent equations for the steady state condition. We also obtain that solutions to the existing models are unrealistic for some cases of the unsteady state condition, because negative drug concentrations occur due to the inappropriate assumption of the model. Therefore, in this paper, we propose a modified mathematical model, so that the model is consistent, and the solution is nonnegative for b

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Anacardio, R., S. Bartolini, M. M. Gentile, M. Bagnasco, and G. Carlucci. "HPLC Investigated Physicochemical Compatibility between Artrosilene® Injectable Solution and other Pharmaceutical Products Frequently Used for Combined Therapy into Elastomeric Baxter LV5 Infusion Devices." International Journal of Immunopathology and Pharmacology 18, no. 4 (2005): 791–98. http://dx.doi.org/10.1177/039463200501800423.

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Ketoprofen lysine salt (Artrosilene®, injectable solution) is a non-steroidal anti-inflammatory agent frequently administered by slow intravenous infusion with portable elastomeric infusion systems in association regimen with other analgesic drugs. The aim of this study was to investigate the physicochemical compatibility between ketoprofen lysine salt (Artrosilene®, injectable solution) and other injectable drugs frequently used in association, such as tramadol hydrochloride, keterolac tromethamine and morphine hydrochloride, into the Infusor LV5, Baxter elastomeric infusion system. Physicoch

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G., V. S. R. Pavan Kumar, Srinivasa Rao K., Sreerama Murty B., and V. N. Partha Sarathi T. "Molybdenum blue method for the spectrophotometric determination of acetazolamide and piracetam." Journal of Indian Chemical Society 93, Jun 2016 (2016): 667–74. https://doi.org/10.5281/zenodo.5638682.

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Department of Chemistry, M. V. G. R. College of Engineering, Vijayramnagar Campus, Chintalavalasa, Vizianagaram-535 002, Andhra Pradesh, India <em>E-mail</em> : prs_ganti@yahoo.co.in <em>Manuscript received 02 February 2016, accepted 23 February 2016</em> A novel method for the spectrophotometric determination of acetazolamide and piracetam in pharmaceutical formulations using molybdenum blue complex formation was developed by the authors. Aqueous and acidic solutions of the drug sample of acetazolamide on reaction with ammonium molybdate solution and hydrazine sulphate solution gave a clear,

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Négrier, Laura, Anthony Martin Mena, Christian Dupont, et al. "The Infusion of Piperacillin/Tazobactam with an Elastomeric Device: A Combined 24-H Stability Study and Drug Solution Flow Rate Analysis." Pharmaceuticals 17, no. 8 (2024): 1085. http://dx.doi.org/10.3390/ph17081085.

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Bacterial respiratory tract infections (e.g., in patients with cystic fibrosis) may be treated with the intravenous infusion of a piperacillin/tazobactam (P/T) solution through an elastomeric device. In the present work, we combined a 24-h drug stability study with an assessment of the drug solution flow rate during an in vitro simulated infusion. Experiments were performed in triplicate with two excipient-free generic P/T solutions and an excipient-containing proprietary P/T solution in saline (all 50/6.25 mg/mL) released from an elastomeric infusion device at 32 °C. The P/T solutions’ stabil

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