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Dissertations / Theses on the topic 'Early detection of heart disease'

Author: Grafiati

Published: 12 May 2023

Last updated: 31 July 2025

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1

Hartnick, Maria Diana. "Echocardiography for early detection of heart disease in high risk diabetic patients." Thesis, Cape Peninsula University of Technology, 2015. http://hdl.handle.net/20.500.11838/1566.

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Masters of Technology: Radiography in the Faculty of Health and Wellness Sciences at the Cape Peninsula University of Technology 2015<br>Introduction: Diabetes mellitus is a chronic disease with a significant impact on personal lifestyle and wellbeing. It is associated with a high prevalence of myocardial disease, the early detection of which is important for prevention of disease progression. Although echocardiography is recognised as a leading cardiovascular imaging modality, there has been limited work on its role in the early detection of diabetes-related myocardial dysfunction. Th

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2

Kounali, Daphne. "Early growth and coronary heart disease." Thesis, University of Southampton, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.436926.

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Springer, David Brian. "Mobile phone-based rheumatic heart disease detection." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:5ec8c818-dafb-4571-8198-97607f8d0451.

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Rheumatic heart disease (RHD), the permanent damage of the heart valves caused by an untreated 'strep throat' infection, is the leading cause of cardiovascular mortality and morbidity in children and young adults worldwide. Simple penicillin treatment after the early diagnosis of RHD can stop recurring bouts of the condition, which lead to the most severe valvulopathy, and ultimately, heart failure. However, RHD is an under-diagnosed condition in the developing world, as such a diagnosis requires, at a minimum, a trained clinician to perform auscultation to detect pathological heart sounds. Tr

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4

Bull, Adrian Richard. "Early determinants of blood pressure and related disease." Thesis, University of Southampton, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.238962.

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5

Suh, Doug Young. "Knowledge-based boundary detection system : on MRI cardiac image sequences." Diss., Georgia Institute of Technology, 1990. http://hdl.handle.net/1853/13291.

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6

Pursiainen, V. (Ville). "Autonomic dysfunction in early and advanced Parkinson's disease." Doctoral thesis, University of Oulu, 2007. http://urn.fi/urn:isbn:9789514283888.

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Abstract Parkinson's disease (PD) is known to affect both the extrapyramidal system and the autonomic nervous system even in the early phases of the disease. This study was designed to evaluate cardiovascular autonomic regulation in early PD by measuring heart rate (HR) variability from 24-hour ECG recordings. The dynamics of blood pressure (BP), HR and sweating in patients with and without wearing-off were assessed during clinical observations after a morning dose of levodopa. In patients with wearing-off the tests were repeated after selegiline withdrawal. The power spectral components of H

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7

Shen, Ze-ping. "An application of neural networks for the detection of coronary heart disease." Thesis, Brunel University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385186.

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8

Heard, Stephanie. "Plant pathogen sensing for early disease control." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/plant-pathogen-sensing-for-early-disease-control(48949f80-2596-4ce2-912a-6513e72f6a8d).html.

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Sclerotinia sclerotiorum, a fungal pathogen of over 400 plant species has been estimated to cost UK based farmers approximately £20 million per year during severe outbreak (Oerke and Dehne 2004). S. sclerotiorum disease incidence is difficult to predict as outbreaks are often sporadic. Ascospores released from the fruiting bodies or apothecia can be dispersed for tens of kilometres. This makes disease control problematic and with no S. sclerotiorum resistant varieties available, growers are forced to spray fungicides up to three times per flowering season in anticipation of the arrival of this

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9

Mendel, Julian L. "Laurel Wilt Disease: Early Detection through Canine Olfaction and "Omics" Insights into Disease Progression." FIU Digital Commons, 2017. http://digitalcommons.fiu.edu/etd/3475.

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Laurel wilt disease is a vascular wilt affecting the xylem and water conductivity in trees belonging to the family Lauraceae. The disease was introduced by an invasive species of ambrosia beetle, Xyleborus glabratus. The beetle, together with its newly described fungal symbiont Raffaelea lauricola (pathogenic to host trees), has lead to the devastation and destruction of over 300 million wild redbay trees in southeastern forests. Ambrosia beetles make up a very unique clade of beetle and share a co-evolved obligatory mutualistic relationship with their partner fungi. Rather than consuming host

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10

Balderson, Diane E. "Observations on the detection of ventricular late potentials." Thesis, Queen's University Belfast, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.238982.

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11

Sridhara, Bangalore Sitaramiah. "Clinical evaluation of '9'9'mTc tetrofosmin in the detection of ischaemic heart disease." Thesis, University of Surrey, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259561.

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12

Olsson, Louise. "Early detection of colorectal cancer /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-841-6/.

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13

Hurrell, Karen Tracy. "Screening for serious disease : modelling the early detection of breast cancer." Thesis, University of Leicester, 1989. http://hdl.handle.net/2381/34546.

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14

Sriram, Deepa. "Early detection of bowel disease in symptomatic patients attending community pharmacies." Thesis, Curtin University, 2016. http://hdl.handle.net/20.500.11937/510.

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With evidence that a substantial number of individuals manage symptoms without seeking medical help, a pharmacy service with symptom management guided by a screening tool should assist in the triage of clients with underlying health conditions. This research describes the successful development, validation and testing of an assessment questionnaire to guide pharmacy staff in identification of pharmacy clients at risk of serious bowel conditions, with referral of clients for further investigation where warranted.

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15

Cunningham, Adam F. "The detection, epidemiology and immunobiology of Chlamydia pneumoniae." Thesis, University of Southampton, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295711.

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Lopez-Alvarez, Jordi. "Evaluation of early indicators of disease progression in dogs with degenerative mitral valve disease." Thesis, Royal Veterinary College (University of London), 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.669194.

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17

Biba, Matilda. "Colour vision within occupations and in the early detection of retinal disease." Thesis, City University London, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.654960.

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Colour is used extensively in the railway industry to enhance conspicuity, code information and group objects of interest together. An acceptable level of colour discrimination is therefore required to enhance visibility even when colour is used redundantly, thus justifying the need to adequately screen all employed personnel. Rail Safety and Standards Board (2002, 2007) state that colour vision must be normal, as assessed by the Ishihara Plates Test or City University test. However, current conventional screening tests are limited in design and have high variability. As a result, a study was

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18

Howard, Newton. "Approach to study the brain : towards the early detection of neurodegenerative disease." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:2f81e9d4-ac91-444f-b966-ce1fc665b065.

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Neurodegeneration is a progressive loss of neuron function or structure, including death of neurons, and occurs at many different levels of neuronal circuitry. In this thesis I discuss Parkinson’s Disease (PD), the second most common neurodegenerative disease (NDD). PD is a devastating progressive NDD often with delayed diagnosis due to detection methods that depend on the appearance of visible motor symptoms. By the time cardinal symptoms manifest, 60 to 80 percent or more of the dopamine-producing cells in the substantia nigra are irreversibly lost. Although there is currently no cure, earli

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19

Ren, Jinyi [Verfasser], and Michael [Akademischer Betreuer] Ewers. "Automated detection of early-stage Alzheimer’s Disease / Jinyi Ren ; Betreuer: Michael Ewers." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1211957322/34.

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20

Forsén, Tom. "Early growth and adult disease : programming of coronary heart disease, type 2 diabetes and hypertension by fetal and childhood growth." Helsinki : University of Helsinki, 2000. http://ethesis.helsinki.fi/julkaisut/laa/kansa/vk/forsen/.

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21

Timmaraju, Venkat Krishna Chaitanya. "Simulating the early detection and intervention of vascular disease in the caerphilly cohort." Thesis, Cardiff University, 2007. http://orca.cf.ac.uk/55711/.

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Introduction: The purpose of the project is to simulate the effect of hypothetical intervention on risk of vascular disease in the Caerphilly cohort. The cohort comprises a total population sample of 2959 men aged 45--59 years at the recruitment who has been followed up for 20 years. During that time there has been particular emphasis on assessing exposure to vascular risk factors and assessing vascular related outcomes. Aim: The aim of the thesis is to estimate the effects at population level of public health interventions to change the levels of modifiable risk factors for the vascular disea

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22

Hett, Kilian. "Multi-scale and multimodal imaging biomarkers for the early detection of Alzheimer’s disease." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0011/document.

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La maladie d’Alzheimer est la première cause de démence chez les personnes âgées. Cette maladie est caractérisée par un déclin irréversible des fonctions cognitives. Les patients atteints par la maladie d’Alzheimer ont de sévères pertes de mémoire et ont de grandes difficultés à apprendre de nouvelles informations ce qui pose de gros problèmes dans leur vie quotidienne. À ce jour, cette maladie est diagnostiquée après que d’importantes altérations des structures du cerveaux apparaissent. De plus, aucune thérapie existe permettant de faire reculer ou de stopper la maladie. Le développement de n

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23

Valluru, Keerthi Srivastav. "Study of Biomolecular Optical Signatures for Early Disease Detection and Cell Physiology Monitoring." University of Akron / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=akron1213627946.

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24

Li, Jiangwei. "Applications of single-molecule detection in early disease diagnosis and enzymatic reaction study." [Ames, Iowa : Iowa State University], 2008.

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25

Figueiredo, Isabel De. "Early Detection of Parkinson's Disease through Microfluidics and Ion Mobility - Mass Spectrometry Integration." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASF070.

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L'alpha-synucléine est un biomarqueur crucial pour la maladie de Parkinson, mais sa détection précoce est difficile en raison de sa faible abondance et de la nature intrinsèquement désordonnée de la protéine. Le développement de méthodes de diagnostic précoces repose fortement sur la compréhension et la différenciation des caractéristiques structurales de l'alpha-synucléine native par rapport à ses formes pathologiques, ces variations offrant des informations précieuses sur le début et la progression de la maladie. Cette thèse de doctorat examine le paysage conformationnel de l'alpha-synucléin

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26

Telford, Lisa Helen. "Standard echocardiography versus handheld echocardiography for the detection of subclinical rheumatic heart disease: A systematic review." Master's thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/29528.

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Rheumatic heart disease (RHD) is a permanent heart valve condition resulting from an abnormal immune reaction to group A streptococcal (GAS) infection typically occurring in childhood. If left untreated, disease progression can result in irreversible heart valve damage, cardiac failure, stroke and premature death. Significantly, RHD is a preventable and treatable chronic condition which mostly effects disadvantaged populations across the world. Moreover, the continued persistence of RHD contributes to considerable amounts of preventable morbidity and mortality, predominantly among adolescents

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27

Sjöberg, Rebecca. "Astrocyte-specific druggable protein as PET-ligand target for early detection of Alzheimer's disease." Thesis, KTH, Skolan för bioteknologi (BIO), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-215308.

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28

Savage, Henry Oluwasefunmi. "Early detection of decompensation of chronic heart failure using a non-contact monitor of nocturnal respiratory patterns." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/24577.

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Heart failure affects 1-2% of the adult population in the United Kingdom and accounts for the majority of hospitalisations in patients with cardiovascular disease. The financial implications are enormous as it consumes 1-2% of the national health care budget with 70% of these costs relating to hospitalisation expenses. Prevention of these admissions may be possible by detecting early signs of decompensation in patients with chronic heart failure (CHF) and instituting interventions that may steer the course of disease back to stability without the need for a hospital inpatient stay. Further, Sl

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29

Palmer, Katie. "Early detection of Alzheimer's disease and dementia in the general population : results from the Kungsholmen project /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-055-9/.

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30

Filali, razzouki Anas. "Deep learning-based video face-based digital markers for early detection and analysis of Parkinson disease." Electronic Thesis or Diss., Institut polytechnique de Paris, 2025. http://www.theses.fr/2025IPPAS002.

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Cette thèse vise à développer des biomarqueurs numériques robustes pour la détection précoce de la maladie de Parkinson (MP) en analysant des vidéos faciales afin d'identifier les changements associés à l'hypomimie. Dans ce contexte, nous introduisons de nouvelles contributions à l'état de l'art : l'une fondée sur l'apprentissage automatique superficiel et l'autre fondée sur l'apprentissage profond. La première méthode utilise des modèles d'apprentissage automatique qui exploitent des caractéristiques faciales extraites manuellement, en particulier les dérivés des unités d'action faciale (AUs)

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Hamshere, Stephen. "Investigation of the effect of early intracoronary autologous bone marrow cell infusion in the management and treatment of acute myocardial infarction." Thesis, Queen Mary, University of London, 2017. http://qmro.qmul.ac.uk/xmlui/handle/123456789/30705.

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Cardiovascular disease (CVD) is a complex combination of multiple conditions. The majority of deaths within CVD include heart attacks and strokes caused by atherosclerotic disease. The pathophysiological process for atherosclerotic disease occurs within the endothelial lining of the vessels of the body. This prolonged process occurs when cholesterol deposits form irregularity in luminal flow resulting in decreased blood flow and ischaemia. This unstable cholesterol plaque can rupture resulting in clot formation and artery occlusion. Within this thesis I aim to show background to the relevant p

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32

Atherton, Daniel Lee. "HYPERSPECTRAL REMOTE SENSING FOR ADVANCED DETECTION OF EARLY BLIGHT (ALTERNARIA SOLANI) DISEASE IN POTATO (SOLANUM TUBEROSUM) PLANTS." OpenSIUC, 2015. https://opensiuc.lib.siu.edu/dissertations/1106.

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Early detection of disease and insect infestation within crops and precise application of pesticides can help reduce potential production losses, reduce environmental risk, and reduce the cost of farming. The goal of this study was the advanced detection of early blight (Alternaria solani) in potato (Solanum tuberosum) plants using hyperspectral remote sensing data captured with a handheld spectroradiometer. Hyperspectral reflectance spectra were captured 10 times over five weeks from plants grown to the vegetative and tuber bulking growth stages. The spectra were analyzed using principal co

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Brunchault, Valérie. "Identification of biomarkers using-omics approach for the early detection of chronic kidney disease and its complications." Thesis, Toulouse 3, 2018. http://www.theses.fr/2018TOU30133/document.

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Diagnostiquer précocement les maladies est un défi à relever pour améliorer la prise en charge des patients concernés et leur offrir une meilleure qualité de vie. Les analyses 'omiques', qui quantifient globalement, simultanément et sans a priori l'abondance de milliers de molécules dans les liquides biologiques, s'avèrent très prometteuses pour l'identification de biomarqueurs précoces des maladies complexes. Dans ce contexte, mon travail de thèse avait pour objectif de développer des outils de diagnostics, à partir d'analyses du peptidome et métabolome urinaire, pour détecter précocement la

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34

Gopalappa, Chaitra. "Three Essays on Analytical Models to Improve Early Detection of Cancer." Scholar Commons, 2010. https://scholarcommons.usf.edu/etd/1647.

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Development of approaches for early detection of cancer requires a comprehensive understanding of the cellular functions that lead to cancer, as well as implementing strategies for population-wide early detection. Cell functions are supported by proteins that are produced by active or expressed genes. Identifying cancer biomarkers, i.e., the genes that are expressed and the corresponding proteins present only in a cancer state of the cell, can lead to its use for early detection of cancer and for developing drugs. There are approximately 30,000 genes in the human genome producing over 500,000

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35

Alhadi, Hafidh A. A. "Role of heart fatty acid binding protein in the early detection of myocardial injury in patients with acute coronary syndromes." Thesis, University of Edinburgh, 2002. http://hdl.handle.net/1842/23007.

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BONZANO, ELISABETTA. "Development of a comprehensive platform for treatment optimization in breast radiotherapy: respiratory gating, heart sparing, early detection of cardiac damage." Doctoral thesis, Università degli studi di Pavia, 2022. http://hdl.handle.net/11571/1463184.

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In the present work, I explored innovative radiotherapy (RT) techniques for treatment optimization in breast cancer patients to spare the heart from radiation exposure and obtain a better and safer treatment strategy. I have implemented a moderate deep inspiration breast hold (DIBH) radiation technique and prospectively collected data on this treatment to assess the efficacy and advantage of this procedure in left breast cancer treatment. This study applied a model-based approach to data by calculating the normal tissue complication probability (NTCP) to determine the probability of damage i

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37

Munder, Tonia [Verfasser]. "Investigation of early histopathological changes in rodent models of Alzheimer's Disease, Parkinson's Disease and CADASIL : brain magnet resonance elastography for early disease detection and staging correlated to histopathology and analysis of neurogenesis and cell survival / Tonia Munder." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2018. http://d-nb.info/1160514887/34.

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Munder, Tonia Laura [Verfasser]. "Investigation of early histopathological changes in rodent models of Alzheimer's Disease, Parkinson's Disease and CADASIL : brain magnet resonance elastography for early disease detection and staging correlated to histopathology and analysis of neurogenesis and cell survival / Tonia Munder." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2018. http://d-nb.info/1160514887/34.

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39

Chaung, Monica. "Role of Lung Clearance Index in the Early Detection of Pulmonary Changes in Children with Sickle Cell Disease." Thesis, The University of Arizona, 2018. http://hdl.handle.net/10150/627163.

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A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.<br>Pulmonary complications including acute chest syndrome are leading causes of sickle cell disease related morbidity and mortality. Studies have shown that pulmonary changes can be detected during childhood. Spirometry is the current standard for measuring lung function. Growing evidence suggests that lung clearance index (LCI) is as sensitive as spirometry in identifying pulmonary changes in pediatric patients. Our cross-section

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40

Pan, Tao. "Towards early stage disease detection in microdevices : fabrication and testing of micro total analysis systems for bioanalytical applications / /." Diss., CLICK HERE for online access, 2007. http://contentdm.lib.byu.edu/ETD/image/etd1836.pdf.

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Pan, Tao. "Towards Early State Disease Detection in Microdevices: Fabrication and Testing of Micro Total Analysis Systems for Bioanalytical Applications." BYU ScholarsArchive, 2007. https://scholarsarchive.byu.edu/etd/1351.

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The past few years have seen a rapid expansion in interest in the characterization of the entire complement of proteins, or proteome. Micro total analysis systems (μTAS) are an emerging promising method, offering rapid, sensitive and low sample consumption separations. I have demonstrated microchip capillary electrophoresis (CE) devices made of CaF2. New methods have been developed for micromachining enclosed capillaries in CaF2. CE analysis of fluorescently labeled amino acids was used to illustrate bioanalytical applications of these microdevices. Initial on-chip infrared spectroscopy result

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Gyenes, Gábor. "Cardiac side-effects of adjuvant radiotherapy for early breast cancer /." [Budapest] ; Stockholm, 1997. http://diss.kib.ki.se/1997/963-9106-04-6.

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43

Comuni, Federica. "A natural language processing solution to probable Alzheimer’s disease detection in conversation transcripts." Thesis, Högskolan Kristianstad, Fakulteten för naturvetenskap, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-19889.

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This study proposes an accuracy comparison of two of the best performing machine learning algorithms in natural language processing, the Bayesian Network and the Long Short-Term Memory (LSTM) Recurrent Neural Network, in detecting Alzheimer’s disease symptoms in conversation transcripts. Because of the current global rise of life expectancy, the number of seniors affected by Alzheimer’s disease worldwide is increasing each year. Early detection is important to ensure that affected seniors take measures to relieve symptoms when possible or prepare plans before further cognitive decline occurs.

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Farajipour, Parisa. "In Vitro Biomarker Detection for Early Diagnosis of Neurodegenerative Diseases via the Ocular Fluid." University of Akron / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=akron1259778648.

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Olsson, Anna, and Denise Nordlöf. "Early screening diagnostic aid for heart disease using data mining : An evaluation using patient data that can be obtained without medical equipment." Thesis, KTH, Skolan för datavetenskap och kommunikation (CSC), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-166593.

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Heart disease is the leading cause of death in the world. Being able to conduct an early screening diagnosis of heart disease at home, could potentially be a tool to reduce the amount of people who lose their lives to the disease in the future. This report aims at investigating if an early screening diagnostic aid using no attributes requiring advanced medical equipment to be measured can be created, that acquires the same level of accuracy as previous data sets and studies. A litera- ture study of medical background, patient data sets and attributes, as well as data mining was conducted. A un

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Kodewitz, Andreas. "Methods for large volume image analysis : applied to early detection of Alzheimer's disease by analysis of FDG-PET scans." Thesis, Evry-Val d'Essonne, 2013. http://www.theses.fr/2013EVRY0005/document.

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Dans cette thèse, nous explorons de nouvelles méthodes d’analyse d’images pour la détection précoce des changements métaboliques cérébraux causés par la maladie d’Alzheimer. Nous introduisons deux apports méthodologiques que nous appliquons à un ensemble de données réelles. Le premier est basé sur l’apprentissage automatique afin de créer une carte des informations pertinentes pour la classification d'un ensemble d’images. Pour cela nous échantillonnons des blocs de Voxels selon un algorithme de Monte-Carlo. La mise en œuvre d’une classification basée sur ces patchs 3d a pour conséquence la ré

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Milano, Isabel. "The Characterization of Alzheimer’s Disease and the Development of Early Detection Paradigms: Insights from Nosology, Biomarkers and Machine Learning." Scholarship @ Claremont, 2019. https://scholarship.claremont.edu/cmc_theses/2192.

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Alzheimer’s Disease (AD) is the only condition in the top ten leading causes of death for which we do not have an effective treatment that prevents, slows, or stops its progression. Our ability to design useful interventions relies on (a) increasing our understanding of the pathological process of AD and (b) improving our ability for its early detection. These goals are impeded by our current reliance on the clinical symptoms of AD for its diagnosis. This characterizations of AD often falsely assumes a unified, underlying AD-specific pathology for similar presentations of dementia that leads t

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Ansart, Manon. "Design of data driven decision support systems for the early detection of subjects at risk to develop Alzheimer's disease." Electronic Thesis or Diss., Sorbonne université, 2019. http://www.theses.fr/2019SORUS450.

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Le but de cette thèse est de proposer des méthodes d’apprentissage automatique pour identifier des sujets à risque de développer la maladie d'Alzheimer. L'identification à un stade très précoce de sujets à risque de développer la maladie est une problématique clé, qui permettrait de mieux étudier la maladie, de sélectionner des patients pour des essais cliniques et de leur proposer un suivi adapté. Dans un premier chapitre, nous effectuons une revue des méthodes prédisant le diagnostic futur de sujets atteints de troubles cognitifs légers. Nous effectuons un travail de synthèse, à la fois qual

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Matthew, Shona. "The development and assessment of cardiac magnetic resonance imaging for the detection of age- and disease-related changes in the human heart." Thesis, University of St Andrews, 2012. http://hdl.handle.net/10023/3558.

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Cardiovascular disease (CVD) is a term used to describe a variety of diseases and events that impact the heart and circulatory system. CVD is the United Kingdom's (UKs) biggest killer, causing more than 50,000 premature deaths each year. Early recognition of the potential for magnetic resonance imaging (MRI) to provide a versatile, non-ionising, non-invasive, technique for the assessment of CVD resulted in the modality becoming an area of intense interest in the research, radiology and cardiology communities. The first half of this thesis reviews some of the key developments in magnetic resona

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Kleiren, Emilie. "Towards an early diagnosis of Alzheimer's disease: development of an ATR-FTIR biosensor for the detection of Abeta toxic conformations." Doctoral thesis, Universite Libre de Bruxelles, 2013. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209415.

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Abstract:

As the most prevalent cause of dementia worldwide, Alzheimer’s disease (AD) has become a global issue of public health. By current criteria, diagnosis of this neurodegenerative disorder requires both clinical confirmation of dementia and post-mortem detection of the so-called neurofibrillary tangles and senile plaques in the brain. Yet the main proteinaceous component of these plaques, the amyloid beta peptide (Abeta) is now widely believed to initiate a cascade of events that ultimately leads to Alzheimer’s disease. Besides, extensive evidence supports a pathogenic role of soluble oligomers f

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