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Dissertations / Theses on the topic 'Early Parkinson disease'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Chamoun, Mario-Christofer. "An Alzheimer-type cerebrospinal fluid profile in early Parkinson's disease." Thesis, Umeå universitet, Institutionen för psykologi, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-167374.

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In recent years, several studies have discovered traces of Alzheimer's (AD) biomarkers in a large portion of patients with Parkinson's disease (PD), which have been associated with subsequent dementia (PDD). However, the manifestation of AD biomarkers in PD is not fully understood. At present, few studies have investigated how common AD biomarkers are in newly diagnosed and unmedicated patients with PD. This cross-sectional cohort study investigated whether AD biomarkers were present in unmedicated and newly diagnosed patients with PD and patients with PD and overlapping clinical symptoms (cog

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2

Carola, Giulia. "Investigating early functional alteration in a human iPSC-based model of Parkinson’s Disease." Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/667606.

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Dopaminergic neurons (DAn) were efficiently differentiated from 6 different iPSC lines derived from a 2 control, 3 PD lines, and an isogenic PD line. We characterize the culture at different time point in order to verify the composition of the culture. At day 35 almost 50% of the cells expressed the neuronal marker TUJ1, of which 20% were of DA lineage as judged by TH expression. No astrocytes were found in the culture. Interestingly at day 50 of differentiation the amount of DAn increased up to 25-35% of which 35% were expressing Girk2, a midbrain DA neuronal marker that was not expressed at

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3

Filali, razzouki Anas. "Deep learning-based video face-based digital markers for early detection and analysis of Parkinson disease." Electronic Thesis or Diss., Institut polytechnique de Paris, 2025. http://www.theses.fr/2025IPPAS002.

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Cette thèse vise à développer des biomarqueurs numériques robustes pour la détection précoce de la maladie de Parkinson (MP) en analysant des vidéos faciales afin d'identifier les changements associés à l'hypomimie. Dans ce contexte, nous introduisons de nouvelles contributions à l'état de l'art : l'une fondée sur l'apprentissage automatique superficiel et l'autre fondée sur l'apprentissage profond. La première méthode utilise des modèles d'apprentissage automatique qui exploitent des caractéristiques faciales extraites manuellement, en particulier les dérivés des unités d'action faciale (AUs)

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4

Page, Brent Michael. "Study of an Early Wellness Program in Parkinson ’s Disease: Impact On Quality Of Life And Early Intervention Guidance." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/623632.

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A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.<br>Previous studies have shown that Parkinson’s disease (PD) patients are at an increased risk for a variety of complications impacting health related quality of life (HRQoL). Additionally, these various complications often lead to increased healthcare utilization. Wellness intervention in PD has shown to be effective in improving HRQoL and objective measures of disease burden such as motor functioning. What has not been demonstrated to

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5

Catalá, Maria Moreno. "A multi-dimensional approach for early identification of increased risk of falling in early-onset Parkinson`s disease patients." Doctoral thesis, Humboldt-Universität zu Berlin, Kultur-, Sozial- und Bildungswissenschaftliche Fakultät, 2016. http://dx.doi.org/10.18452/17624.

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Gleichgewichtsstörungen und Stürze gehören zu den wichtigsten Symptomen der Parkinson Krankheit (PD). Bei jungen PD-Patienten werden diese Probleme durch Nebenwirkungen der Medikation zusätzlich verstärkt. Aufgrund des noch sehr limitierten Verständnisses der zugrunde liegenden Mechanismen, die zum erhöhten Sturzrisiko bei jungen PD-Patienten beitragen, mangelt es derzeit an alternativen und effektiven bewegungsbasierten Therapien, um diese Sturzgefahr zu verringern. Diese Arbeit zielt darauf ab, solche Mechanismen zu identifizieren und eine effektive Methode zur Früherkennung des Sturzrisikos

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6

Stiévenard, Aliçia. "Investigation of the roles of ghrelin in experimental models of early stages of Parkinson’s disease : towards a clarification of ghrelin’s diagnostic and therapeutic potentials." Thesis, Lille 2, 2016. http://www.theses.fr/2016LIL2S041/document.

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La maladie de Parkinson (MP) est une maladie neurodégénérative caractérisée par trois symptômes moteurs principaux : la bradykinésie, la rigidité et le tremblement de repos. Son diagnostic définitif repose sur l’identification post-mortem d’une importante mort des neurones dopaminergiques de la substance noire (SN) et la présence de corps de Lewy dans les neurones survivants. Cette maladie progresse lentement et les premiers symptômes moteurs n’apparaissent qu’après la dégénérescence de plus de 50% de la SN. Le diagnostic clinique de MP est donc établi tardivement, réduisant ainsi la fenêtre d

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Stiévenard, Aliçia. "Investigation of the roles of ghrelin in experimental models of early stages of Parkinson’s disease : towards a clarification of ghrelin’s diagnostic and therapeutic potentials." Electronic Thesis or Diss., Lille 2, 2016. http://www.theses.fr/2016LIL2S041.

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La maladie de Parkinson (MP) est une maladie neurodégénérative caractérisée par trois symptômes moteurs principaux : la bradykinésie, la rigidité et le tremblement de repos. Son diagnostic définitif repose sur l’identification post-mortem d’une importante mort des neurones dopaminergiques de la substance noire (SN) et la présence de corps de Lewy dans les neurones survivants. Cette maladie progresse lentement et les premiers symptômes moteurs n’apparaissent qu’après la dégénérescence de plus de 50% de la SN. Le diagnostic clinique de MP est donc établi tardivement, réduisant ainsi la fenêtre d

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8

Figueiredo, Isabel De. "Early Detection of Parkinson's Disease through Microfluidics and Ion Mobility - Mass Spectrometry Integration." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASF070.

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L'alpha-synucléine est un biomarqueur crucial pour la maladie de Parkinson, mais sa détection précoce est difficile en raison de sa faible abondance et de la nature intrinsèquement désordonnée de la protéine. Le développement de méthodes de diagnostic précoces repose fortement sur la compréhension et la différenciation des caractéristiques structurales de l'alpha-synucléine native par rapport à ses formes pathologiques, ces variations offrant des informations précieuses sur le début et la progression de la maladie. Cette thèse de doctorat examine le paysage conformationnel de l'alpha-synucléin

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Moreno, Catalá María [Verfasser], Adamantios [Gutachter] Arampatzis, Kirsten [Gutachter] Legerlotz, and Hendrik [Gutachter] Schmidt. "A multi-dimensional approach for early identification of increased risk of falling in early-onset Parkinson`s disease patients / Maria Moreno Catalá ; Gutachter: Adamantios Arampatzis, Kirsten Legerlotz, Hendrik Schmidt." Berlin : Kultur-, Sozial- und Bildungswissenschaftliche Fakultät, 2016. http://d-nb.info/1117638324/34.

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Moreno, Catalá María Verfasser], Adamantios [Gutachter] [Arampatzis, Kirsten [Gutachter] Legerlotz, and Hendrik [Gutachter] Schmidt. "A multi-dimensional approach for early identification of increased risk of falling in early-onset Parkinson`s disease patients / Maria Moreno Catalá ; Gutachter: Adamantios Arampatzis, Kirsten Legerlotz, Hendrik Schmidt." Berlin : Kultur-, Sozial- und Bildungswissenschaftliche Fakultät, 2016. http://d-nb.info/1117638324/34.

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11

Siepmann, Timo, Alexandra Pintér, Sylvia J. Buchmann, et al. "Cutaneous Autonomic Pilomotor Testing to Unveil the Role of Neuropathy Progression in Early Parkinson’s Disease (CAPTURE PD): Protocol for a Multicenter Study." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-230507.

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Background: In Parkinson’s disease (PD), alpha-synuclein accumulation in cutaneous autonomic pilomotor and sudomotor nerve fibers has been linked to autonomic nervous system disturbances even in the early stages of the disease. This study aims to assess the association between alpha-synuclein-mediated structural autonomic nerve fiber damage and function in PD, elucidate the role of neuropathy progression during the early disease stages, and test reproducibility and external validity of pilomotor function assessment using quantitative pilomotor axon-reflex test and sudomotor function via quanti

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12

ATZORI, ALESSIO. "Extraction of vocal features for health assessment and early diagnosis - Effects of measurement uncertainty on classification algorithms." Doctoral thesis, Politecnico di Torino, 2022. http://hdl.handle.net/11583/2972104.

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13

Konstantopoulos, Konstantinos. "Dysarthria in early Parkinson's disease." Thesis, University College London (University of London), 2004. http://discovery.ucl.ac.uk/10055767/.

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The aim of the present study was threefold. First, to examine the incidence of dysarthria in patients in the beginning of Parkinson's disease by using a standardised test (Frenchay Dysarthria Assessment/FDA) and an intelligibility assessment tool. Second, to identify differences in speech and in measures of phonation between the Parkinsonian group and a matched control geriatric group using the FDA and electrolaryngography. Finally, to identify the effect of medication on speech and phonation in the dysarthric Parkinsonian group. The results showed that 8 out of 12 (66%) Parkinsonian subjects

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14

Bastide, Matthieu. "Approche expérimentale de la physiopathologie des dyskinésies L-Dopa induites dans la maladie de Parkinson : comparaison de la cible classique, le striatum avec l’ensemble du cerveau." Thesis, Bordeaux, 2014. http://www.theses.fr/2014BORD0132/document.

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Le traitement de référence de la maladie de Parkinson (MP) reste l’utilisation du précurseurdirect de la dopamine: la L-3,4-dihydroxyphenylalanine (L-Dopa). Le traitement chroniquedes patients parkinsoniens à la L-Dopa induit, en revanche, systématiquement desmouvements involontaires anormaux que l’on qualifie de dyskinésies induites par la L-Dopa(DIL). L’étude de l’expression des dyskinésies s’est essentiellement focalisée sur lesdysfonctions neuronales engendrées dans les régions motrices des ganglions de la base et apermis de révéler une surexpression significative de gènes de réponse préco

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15

Taleb, Catherine. "Parkinson's desease detection by multimodal analysis combining handwriting and speech signals." Electronic Thesis or Diss., Institut polytechnique de Paris, 2020. http://www.theses.fr/2020IPPAT039.

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La maladie de Parkinson (MP) est un trouble neurologique causé par une diminution du niveau de dopamine dans le cerveau. Cette maladie est caractérisée par des symptômes moteurs et non moteurs qui s'aggravent avec le temps. Aux stades avancés de la maladie de Parkinson, le diagnostic clinique est clair. Cependant, dans les premiers stades, lorsque les symptômes sont souvent incomplets ou subtils, le diagnostic devient difficile et, parfois, le sujet peut rester non diagnostiqué. En outre, il n'existe pas de méthodes efficaces et fiables permettant d'établir avec certitude un diagnostic précoce

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16

Kudlicka, Aleksandra Katarzyna. "Executive functioning in early stage Parkinson's disease." Thesis, Bangor University, 2013. https://research.bangor.ac.uk/portal/en/theses/executive-functioning-in-early-stage-parkinsons-disease(4985b570-fd51-48ba-8c39-f377b5e2edf0).html.

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Background: Cognitive decline is commonly reported in Parkinson’s disease (PD), with some deficits evident even at the onset of PD. Executive functions (EF) are extensively studied in PD and emerge as the domain involving the most profound deficits. Nevertheless, there are some inconsistencies in the literature with regard to the exact pattern of executive deficits and their impact on everyday life in PD. The aim of the literature review presented in this thesis was to synthesise and clarify existing research evidence on EF in early stage PD, and to explore what are the possible factors affect

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17

Pursiainen, V. (Ville). "Autonomic dysfunction in early and advanced Parkinson's disease." Doctoral thesis, University of Oulu, 2007. http://urn.fi/urn:isbn:9789514283888.

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Abstract Parkinson's disease (PD) is known to affect both the extrapyramidal system and the autonomic nervous system even in the early phases of the disease. This study was designed to evaluate cardiovascular autonomic regulation in early PD by measuring heart rate (HR) variability from 24-hour ECG recordings. The dynamics of blood pressure (BP), HR and sweating in patients with and without wearing-off were assessed during clinical observations after a morning dose of levodopa. In patients with wearing-off the tests were repeated after selegiline withdrawal. The power spectral components of H

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18

Szewczyk-Krolikowski, Konrad. "Clinical and imaging characteristics of early Parkinson's disease." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:c118f620-19a9-4d0c-bcfc-018e3dd9ff3d.

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<strong>Background</strong>. Pathological processes in Parkinson’s disease (PD) start long before the first symptoms appear and by the time the disease is clinically established the results of neurodegeneration may be irreversible. Efforts to prevent or stem disease progression need to start in early disease and good characterization and new markers of early PD are urgently needed. <strong>Objectives</strong>. This thesis aims to characterize early disease stages in three projects. Firstly, clinical features of PD within 3 years of diagnosis will be explored in an incident cohort of patients a

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19

Possin, Katherine L. "Visuospatial and visual object cognition in early Parkinson's disease." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2007. http://wwwlib.umi.com/cr/ucsd/fullcit?p3250074.

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Thesis (Ph. D.)--University of California, San Diego and San Diego State University, 2007.<br>Title from first page of PDF file (viewed April 4, 2007). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 128-166).

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20

Sullivan, Kelly. "Indicators of Early Adult and Current Personality in Parkinson's Disease." Scholar Commons, 2011. http://scholarcommons.usf.edu/etd/3371.

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Introduction: Previous epidemiologic studies suggest that the personality of Parkinson's disease (PD) patients differs from that of controls, and laboratory evidence supports a potential common pathophysiology of personality traits and PD. One nested case-control study found that PD cases were significantly more anxious than controls before the clinical onset of the disease, and additional data suggest that certain occupations may be risk factors for the disease. Additionally, the latent period that precedes the onset of motor symptoms of PD is unknown. Objectives: The objectives of this study

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Malek, Naveed. "Variation in Parkinson's disease : age, gender, genotype and phenotype correlations in early onset disease." Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/5602/.

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There is a wide variation in the phenotypic expression, progression rates, therapy response and complications in Parkinson’s disease (PD). The primary research objective in this thesis was to analyse the variation in the 4 domains of phenotypic expression i.e. motor, non-motor, cognitive, and quality of life in a subset of early onset Parkinson’s disease (EOPD) patients from the PRoBaND study, in the United Kingdom. The secondary objective was to explore the factors responsible for this variation or heterogeneity in the clinical characteristics. Linking genotypes with phenotypes, besides evalu

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Domellöf, Magdalena Eriksson. "Cognitive and motor dysfunction in the early phase of Parkinson's disease." Doctoral thesis, Umeå universitet, Institutionen för farmakologi och klinisk neurovetenskap, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-82897.

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Background: Parkinson’s disease (PD) is a chronic and progressive neurodegenerative disease. The diagnosis is based on a combination of the motor signs: tremor, bradykinesia, rigidity and postural abnormalities. Mild Cognitive Impairment (MCI) is common early in the disease and a large proportion of patients with PD develop dementia (PDD). Associations between motor symptoms and cognitive decline have been suggested but the results are inconclusive due to differences in the selection of participants and variables tested. Large population based studies with comprehensive neuropsychological inve

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23

Ho, Arthur Yau Wing. "Recommendation for using deep brain stimulation in early stage Parkinson's disease." Thesis, Boston University, 2013. https://hdl.handle.net/2144/21175.

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Thesis (M.A.) PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Parkinson's disease is a progressively debilitating disease that affects about 1% of the world's population, and does not differentiate between genders or races. The disease is caused by the death of the dopaminergic neurons in the

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Lui, Nga Ping. "Endogenous neuroprotective mechanisms in early stages of rat parkinsonism." HKBU Institutional Repository, 2011. http://repository.hkbu.edu.hk/etd_ra/1251.

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Conrado, Daniela J., Timothy Nicholas, Kuenhi Tsai, et al. "Dopamine Transporter Neuroimaging as an Enrichment Biomarker in Early Parkinson's Disease Clinical Trials: A Disease Progression Modeling Analysis." WILEY, 2018. http://hdl.handle.net/10150/626602.

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Given the recognition that disease-modifying therapies should focus on earlier Parkinson's disease stages, trial enrollment based purely on clinical criteria poses significant challenges. The goal herein was to determine the utility of dopamine transporter neuroimaging as an enrichment biomarker in early motor Parkinson's disease clinical trials. Patient-level longitudinal data of 672 subjects with early-stage Parkinson's disease in the Parkinson's Progression Markers Initiative (PPMI) observational study and the Parkinson Research Examination of CEP-1347 Trial (PRECEPT) clinical trial were ut

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Kaladytė, Lokominienė Rūta. "Cognitive functions in early-stage Parkinson's disease according to computerised test results, their relationship with biological markers and clinical non-cognitive symptoms." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20140303_135449-49961.

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The aim of the study: to evaluate the cognitive functions of patients with early-stage Parkinson‘s disease (PD) without dementia using Cambridge Neuropsychological Test Automated Battery (CANTAB Eclipse 3.0.0), to compare the obtained results with the data of control subjects, to determine the associations of the variables of cognitive testing with biological markers and clinical non-cognitive symptoms of PD. Objectives: to examine attention, memory, visuospatial and executive functions of patients with early-stage PD without dementia using CANTAB Eclipse 3.0.0 and to compare the obtained res

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27

Stephens, Aubree. "Non-motor symptoms and their use as markers for prodromal and early Parkinson's disease." Thesis, Uppsala universitet, Institutionen för organismbiologi, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-445208.

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Parkinson’s Disease (PD) is the second most common neurodegenerative disorder. It is a disease with a broad spectrum of symptoms, both motor and non-motor, but is often only diagnosed when the motor symptoms begin to appear. By this time however, a large amount of the dopaminergic neurons of the substantia nigra pars compacta have already deteriorated. It is therefore of great interest to be able to diagnose the disease earlier on in its progression and perhaps slow down or halt its course. Recent literature has supported the idea that non-motor symptoms begin to appear years, perhaps even dec

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Ortuño-Lizarán, Isabel. "Cellular alterations of the human retina in Parkinson’s disease and their use as early biomarkers." Doctoral thesis, Universidad de Alicante, 2019. http://hdl.handle.net/10045/118447.

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En la presente Tesis Doctoral se describen los cambios celulares que ocurren en la retina en la enfermedad de Parkinson y su posible uso como biomarcadores tempranos de la enfermedad. Los pacientes con enfermedad de Parkinson poseen acumulaciones de alfa sinucleína fosforilada en la retina similares a las que se encuentran en el cerebro de los mismos pacientes. De hecho, la cantidad de alfa-sinucleína fosforilada en la retina correlaciona con la cantidad de alfa-sinucleína fosforilada en el cerebro, con el estadio de progresión de la enfermedad y con la severidad de los síntomas motores. Ademá

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Buckley, Christopher. "Upper body accelerations as a biomarker of gait impairment in the early stages of Parkinson's disease." Thesis, University of Sheffield, 2017. http://etheses.whiterose.ac.uk/19779/.

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Neurodegenerative diseases such as Parkinson's disease (PD) impair the ability to walk safely and efficiently. Currently, clinical rating scales designed to assess gait are often described to be subjective and lacking sensitivity to detect gait impairments at the early stage of the disease. Devices are available to objectively measure gait within research laboratories; however, they are often expensive and require trained expertise. Inertial measurement units (IMUs) may be an ideal device to measure gait while overcoming many of the limitations of other devices. They can measure movements of t

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Geng, Jiao [Verfasser], and Jochen [Akademischer Betreuer] Herms. "Early changes in miRNAs in a mouse model of Parkinson's Disease / Jiao Geng ; Betreuer: Jochen Herms." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1226092357/34.

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Sarini, Sarini. "Statistical methods for modelling falls and symptoms progression in patients with early stages of Parkinson's disease." Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/116208/1/_Sarini_Thesis.pdf.

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This thesis was a step forward in gaining insight into falls in people with early stages of Parkinson's disease (PD), and in monitoring the disease progression based on clinical assessments. This research contributes new knowledge by providing new insights into utilizing information provided by the clinically administered instruments used routinely for the assessment of PD severity. The novel approach to modelling the progression of PD symptoms using multi-variable clinical assessment measurements for longitudinal data provides a new perspective into disease progression.

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Kaladytė, Lokominienė Rūta. "Ankstyva Parkinsono liga sergančiųjų pažinimo funkcijos remiantis kompiuterizuotais testais, jų ryšys su biologiniais žymenimis ir klinikiniais nekognityviniais simptomais." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20140303_135434-58570.

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Darbo tikslas: įvertinti ankstyva Parkinsono liga (PL) be demencijos sergančių asmenų pažinimo funkcijas naudojant Kembridžo kompiuterinės neuropsichologinio ištyrimo sistemos testų rinkinį, palyginti rezultatus su kontrolinės grupės asmenų duomenimis bei nustatyti kognityvinių rodiklių ryšius su biologiniais žymenimis ir klinikiniais nekognityviniais PL simptomais. Darbo uždaviniai: ištirti ankstyva PL sergančių asmenų dėmesio, atminties, regos erdvinę ir vykdomąsias funkcijas, naudojant kompiuterizuotų testų rinkinį CANTAB eclipse 3.0.0, ir palyginti juos su kontrolinių asmenų duomenimis; n

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Khan, Naheed Lubna. "Familial parkinsonism (Parkinson's disease and early onset parkinsonism) : a genetic, clinical study and 18F-dopa PET study." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1444816/.

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This thesis reports a study of familial parkinsonism using diverse scientific tools of both molecular genetics and positron emission tomography functional imaging. Population-based allelic association studies are also described. Molecular and clinical characterisation of the largest British kindred with autosomal Parkinson's disease (PD). Genome wide linkage analysis was used to map the sub-chromosomal location of the disorder as the first step for disease-gene identification. The disease mapped to a 50cM region on the short arm of chromosome 12 overlapping a locus, PARK8 that had just been re

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Cirnaru, M. D. "IMPACT OF LRRK2 KINASE ACTIVITY AT THE PRE-SYNAPTIC SITE: EARLY AND LATE EFFECTS ON PARKINSON'S DISEASE." Doctoral thesis, Università degli Studi di Milano, 2016. http://hdl.handle.net/2434/353078.

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Parkinson’s disease (PD) is a common neurodegenerative disease clinically characterized by bradykinesia, rigidity and resting tremor. PD is characterized pathologically by the degeneration of nigrostriatal dopaminergic neurons and the presence of Lewy bodies containing a small protein, alpha-synuclein. Mutations in Leucine-rich repeat kinase 2 gene (LRRK2) are associated with familial and sporadic Parkinson’s disease (PD). LRRK2 is a complex protein that consists of multiple domains executing several functions, including GTP hydrolysis, kinase activity, and protein binding. There are many sing

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Warton, Fleur L. "The effects of early developmental stress and exercise intervention on neurodegeneration in a rat model of Parkinson's disease." Master's thesis, University of Cape Town, 2010. http://hdl.handle.net/11427/11069.

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Includes bibliographical references (p. 224-253).<br>Early developmental stress has been shown to produce numerous deleterious effects, e.g. the later development of affective disorders, and this has been related to chronic enhanced hypothalamic-pituitary-adrenal axis activity. Animal studies have shown that maternally separated rats exhibit increased anxiety- and depression-like behaviour in adulthood, although other evidence shows hyperactivity and impulsivity in such cases. Given that stress has these behavioural effects, it is of interest to determine whether early developmental stress mig

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Munder, Tonia [Verfasser]. "Investigation of early histopathological changes in rodent models of Alzheimer's Disease, Parkinson's Disease and CADASIL : brain magnet resonance elastography for early disease detection and staging correlated to histopathology and analysis of neurogenesis and cell survival / Tonia Munder." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2018. http://d-nb.info/1160514887/34.

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Munder, Tonia Laura [Verfasser]. "Investigation of early histopathological changes in rodent models of Alzheimer's Disease, Parkinson's Disease and CADASIL : brain magnet resonance elastography for early disease detection and staging correlated to histopathology and analysis of neurogenesis and cell survival / Tonia Munder." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2018. http://d-nb.info/1160514887/34.

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Pu, Christopher Hao. "Quantitative mass spectrometry to discover interactors of parkin E3 ubiquitin ligase, a protein implicated in early-onset Parkinson's disease." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/17757.

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Ubiquitylation is a major post-translational modification based on a network of about six hundred E3 ubiquitin ligases in human. It is involved in several processes such as proteolysis, vesicle trafficking and DNA damage response. Mutations in PARK2, which encode parkin E3 ubiquitin ligase, account for half of autosomal recessive juvenile Parkinsonism cases, an early onset form of Parkinson’s disease. Multiple PARK2 mutations underlie the RING domain, which contains ligase activity. This finding suggests an inability for substrate ubiquitylation may trigger neurodegeneration. We used a quantit

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Umemura, Atsushi. "Diagnostic Accuracy of Apparent Diffusion Coefficient and 123I-Metaiodobenzylguanidine for Differentiation of Multiple System Atrophy and Parkinson's Disease." Kyoto University, 2015. http://hdl.handle.net/2433/200316.

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PASQUINI, JACOPO. "Multimodal Magnetic Resonance Imaging for the identification of early Multiple System Atrophy biomarkers." Doctoral thesis, Università degli Studi di Milano, 2022. http://hdl.handle.net/2434/890787.

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Background. Multiple system atrophy (MSA) is a rare, sporadic disease characterized by autonomic failure and a various combination of parkinsonism and cerebellar dysfunction. Currently, development of new treatment strategies in MSA is hampered by the lack of reliable diagnostic and disease-progression biomarkers. The aim of this study was to investigate brain microstructural abnormalities in MSA through diffusion and neuromelanin-sensitive magnetic resonance imaging (MRI) and their relationship with clinical manifestations. Methods. Clinical evaluation and MRI were performed on 11 MSA patie

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Pérez, Pi Irene. "Design and development of a novel bead-based assay for early stage alpha-synuclein aggregation." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28761.

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α-synuclein is a small presynaptic protein whose misfolding and aggregation are considered drivers of the neurological disorders Parkinson’s disease, multiple system atrophy, dementia with Lewy bodies and related synucleopathies. α-synuclein exists in a dynamic state that changes from an α-helical conformation when bound to liposomes to natively unfolded in solution, the majority being in the latter state. The disease process by which native healthy α-synuclein undergoes a change in conformation to form β-sheet oligomers and fibrils is still unresolved. The fibrillation process has been widely

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Parisi, Luca. "Machine Learning-based Feature Selection and Optimisation for Clinical Decision Support Systems. Optimal Data-driven Feature Selection Methods for Binary and Multi-class Classification Problems: Towards a Minimum Viable Solution for Predicting Early Diagnosis and Prognosis." Thesis, University of Bradford, 2019. http://hdl.handle.net/10454/18417.

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This critical synopsis of prior work by Luca Parisi is submitted in support of a PhD by Published Work. The work focuses on deriving accurate, reliable and explainable clinical decision support systems as minimum clinically viable solutions leveraging Machine Learning (ML) and evolutionary algorithms, for the first time, to facilitate early diagnostic predictions of Parkinson's Disease and hypothermia in hospitals, as well as prognostic predictions of optimal postoperative recovery area and of chronic hepatitis. Despite the various pathological aetiologies, the underlying capabil

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Brockelt, David [Verfasser], Judith [Akademischer Betreuer] [Gutachter] Stegmüller, and Tiago Fleming [Gutachter] Outeiro. "The role of the E3 ubiquitin ligase FBXO7-SCF in early-onset Parkinson's disease / David Brockelt. Betreuer: Judith Stegmüller. Gutachter: Judith Stegmüller ; Tiago Fleming Outeiro." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2016. http://d-nb.info/1112736522/34.

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Prashanth, R. "Computer-aded early detection of parkinson`s disease through multimodal data analysis." Thesis, 2015. http://localhost:8080/xmlui/handle/12345678/6910.

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Hsiao, Chih-Wen, and 蕭至紋. "Probabilistic cost-effectiveness analysis for early detection of Parkinson''s disease." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/70581723336290293867.

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碩士<br>國立臺灣大學<br>流行病學與預防醫學研究所<br>99<br>Background: Parkinson''s disease (PD) is the second most common neurodegenerative disease in Taiwan. A total of 85,510 patients suffered from PD have been under treated in 2008 in Taiwan. It has been showed that screening for early PD can lead to 51% reduction for late stage of PD, and 25% mortality reduction. Thus, early detection could relieve medical burden from PD for patients themselves, the family members, and even for society. However, the cost-effectiveness of PD screening was never addressed. The aim of this thesis was to evaluate the co

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Adrião, Mariana Filipa de Oliveira Manuel. "Pharmacological modulation of DJ-1 : relevance in early onset autosomal recessive Parkinson's disease." Master's thesis, 2012. http://hdl.handle.net/10316/81435.

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Trabalho final de mestrado integrado em Medicina área científica de Farmacologia, apresentado á Faculdade de Medicina da Universidade de Coimbra<br>O tratamento atual para a Doença de Parkinson (DP), como a levodopa (L-DOPA) e os agonistas dopaminérgicos, pode efetivamente reverter os sintomas motores da doença. No entanto, além dos efeitos adversos associados aos fármacos, como a discinesia associada à LDOPA, até a terapêutica farmacológica disponível não é capaz de prevenir o seu aparecimento ou de travar a evolução da doença. Assim, tem sido colocado muito enfâse na descoberta dos fato

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Salvado, Ruben Joel Bispo. "Oxidative Stress Biomarkers: Closer to early diagnosis of neurodegenerative diseases?" Master's thesis, 2017. http://hdl.handle.net/10316/83037.

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Dissertação de Mestrado em Química Forense apresentada à Faculdade de Ciências e Tecnologia<br>Parkinson’s disease (PD) is a neurodegenerative disorder, the second most common after Alzheimer’s disease, and the most common age-associated movement disorder, affecting 1% of the population over 60 years old. The cause of the disease is not yet known, but some of the factors that contribute for its appearance can be grouped in genetic and environmental factors.The symptoms usually appear when the loss of dopaminergic neurons in the substantia nigra exceeds 60%, with this being the only characteris

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Huang, Chu-Yun, and 黃楚雲. "The Feasibility of Overnight Switching of Pramipexole from Immediate-release to Extended-release Formulation in Early Parkinson''s Disease: An Open-labeled, Crossover Study in Taiwan." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/05201880697333044257.

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Graça, Ricardo. "ParkDetect - Early Diagnosing Parkinsons Disease." Dissertação, 2013. http://hdl.handle.net/10216/76048.

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Graça, Ricardo Gabriel da Silva. "ParkDetect - Early Diagnosing Parkinson's Disease." Master's thesis, 2013. https://repositorio-aberto.up.pt/handle/10216/67646.

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A doença de Parkinson é uma das doenças neurodegenerativas do sistema central nervoso mais comuns que afeta, principalmente, idosos. Existem quatro sintomas principais da doença: tremores, rigidez, movimentos lentos e instabilidade na postura. Atualmente qualquer tipo de diagnóstico é feito através de observação por parte de um profissional de saúde treinado nesta área. Então é necessário um método que seja simples e eficaz para que profissionais de saúde de, por exemplo, clínica geral possam efetuar para reencaminhar um possível paciente da doença para um especialista. Neste contexto uma apli

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