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Journal articles on the topic 'Early Years (5 - 10 years)'

Author: Grafiati

Published: 4 June 2021

Last updated: 19 February 2022

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1

Morgan, D. A. L., H. Fiona Robinson, Leela Marsh, and P. J. Bradley. "Vocal quality 10 years after radiotherapy for early glottic cancer." Clinical Radiology 39, no. 3 (January 1988): 295–96. http://dx.doi.org/10.1016/s0009-9260(88)80541-5.

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Loeb, S., Z. Feng, A. Ross, B. J. Trock, E. B. Humphreys, and P. C. Walsh. "Can PSA testing stop 10 years after radical prostatectomy?" Journal of Clinical Oncology 29, no. 7_suppl (March 1, 2011): 179. http://dx.doi.org/10.1200/jco.2011.29.7_suppl.179.

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179 Background: Biochemical recurrence (BCR) most frequently occurs within the first five years following radical prostatectomy. Prior studies have suggested an association between lower-risk disease features and BCR at 5 years postoperatively. The objective of our study was to determine predictors of BCR ≥10 years after radical prostatectomy, and to examine the relationship between timing of BCR with the subsequent risk of metastases and cancer-specific mortality. Methods: Among 10,609 men from our institutional radical prostatectomy database, we identified 1684 men with BCR (PSA >0.2 ng/m

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Gómez-Palomares, JL, B. Acevedo-Martín, L. Andrés, E. Ricciarelli, and ER Hernández. "LH improves early follicular recruitment in women over 38 years old." Reproductive BioMedicine Online 12, no. 1 (January 2006): 132. http://dx.doi.org/10.1016/s1472-6483(10)60993-5.

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Gómez-Palomares, JL, B. Acevedo-Martín, L. Andrés, E. Ricciarelli, and ER Hernández. "LH improves early follicular recruitment in women over 38 years old." Reproductive BioMedicine Online 11, no. 4 (January 2005): 409–14. http://dx.doi.org/10.1016/s1472-6483(10)61131-5.

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Gray, Richard G., Daniel Rea, Kelly Handley, Sarah Jane Bowden, Philip Perry, Helena Margaret Earl, Christopher John Poole, et al. "aTTom: Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years in 6,953 women with early breast cancer." Journal of Clinical Oncology 31, no. 18_suppl (June 20, 2013): 5. http://dx.doi.org/10.1200/jco.2013.31.18_suppl.5.

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5 Background: In estrogen-receptor-positive (ER+) early breast cancer, 5 years of tamoxifen reduces breast cancer death rates by about a third throughout years 0-14. It has been uncertain how 10 years of tamoxifen compares with this. Methods: During 1991-2005, 6,953 women with ER+ (n=2755), or ER untested (4198, estimated 80% ER+ if status known) invasive breast cancer from 176 UK centres were, after 5 years of tamoxifen, randomized to stop tamoxifen or continue to year 10. Annual follow-up recorded compliance, recurrence, mortality, and hospital admissions. Results: Allocation to continue tam

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Sheridan, Margaret, Maria Kharitonova, Rebecca E. Martin, Aparna Chatterjee, and John D. E. Gabrieli. "Neural Substrates of the Development of Cognitive Control in Children Ages 5–10 Years." Journal of Cognitive Neuroscience 26, no. 8 (August 2014): 1840–50. http://dx.doi.org/10.1162/jocn_a_00597.

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Cognitive conflict detection and resolution develops with age across childhood and likely supports age-related increases in other aspects of cognitive and emotional development. Little is known about the neural correlates of conflict detection and resolution in early childhood. In the current study, we investigated age-related change in neural recruitment during a blocked spatial-incompatibility task (Simon task) in children ages 5–10 years using fMRI. Cortical thickness was measured using structural MRI. Across all children, there was greater activation in right prefrontal and bilateral parie

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Awdish, Rana L. A., and Hector R. Cajigas. "Early Initiation of Prostacyclin in Portopulmonary Hypertension: 10 Years of a Transplant Center’s Experience." Lung 191, no. 6 (August 25, 2013): 593–600. http://dx.doi.org/10.1007/s00408-013-9501-5.

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Gray, Richard G., Daniel Rea, Kelly Handley, Sarah Jane Bowden, Philip Perry, Helena Margaret Earl, Christopher John Poole, et al. "aTTom: Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years in 6,953 women with early breast cancer." Journal of Clinical Oncology 31, no. 15_suppl (May 20, 2013): 5. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.5.

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5 The full, final text of this abstract will be available at abstract.asco.org at 7:30 AM (EDT) on Sunday, June, 2, 2013, and in the Annual Meeting Proceedings online supplement to the June 20, 2013, issue of Journal of Clinical Oncology. Onsite at the Meeting, this abstract will be printed in the Sunday edition of ASCO Daily News.

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Theander, Lisa, Minna Willim, Jan Åke Nilsson, Magnus Karlsson, Kristina E. Åkesson, Lennart T. H. Jacobsson, and Carl Turesson. "Changes in bone mineral density over 10 years in patients with early rheumatoid arthritis." RMD Open 6, no. 1 (February 2020): e001142. http://dx.doi.org/10.1136/rmdopen-2019-001142.

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ObjectivesTo investigate changes in bone mineral density (BMD) in patients with early rheumatoid arthritis (RA) over a 10-year period.MethodsConsecutive patients with early RA (symptom duration <12 months) were followed according to a structured programme and examined with dual-energy X-ray absorptiometry (DXA) at inclusion and after 2, 5 and 10 years. Mean Z-scores over the study period were estimated using mixed linear effect models. Changes in Z-scores between follow-up visits were analysed using paired T-tests.ResultsAt inclusion, 220 patients were examined with DXA. At the femoral neck

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Hackshaw, Allan, Michael Roughton, Sharon Forsyth, Kathryn Monson, Krystyna Reczko, Richard Sainsbury, and Michael Baum. "Long-Term Benefits of 5 Years of Tamoxifen: 10-Year Follow-Up of a Large Randomized Trial in Women at Least 50 Years of Age With Early Breast Cancer." Journal of Clinical Oncology 29, no. 13 (May 1, 2011): 1657–63. http://dx.doi.org/10.1200/jco.2010.32.2933.

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Purpose The Cancer Research UK “Over 50s” trial compared 5 and 2 years of tamoxifen in women with early breast cancer. Results are reported after median follow-up of 10 years. Patients and Methods Between 1987 and 1997, 3,449 patients age 50 to 81 years with operable breast cancer who had been taking 20 mg of tamoxifen for 2 years were randomly assigned to either stop or continue for an additional 3 years, if they were alive and recurrence free. Data on recurrences, new tumors, deaths, and cardiovascular events were obtained (April 2010). Results There were 1,103 recurrences, 755 deaths as a r

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Roberts, Pauline, Lennie Barblett, and Ken Robinson. "Early years teachers’ perspectives on the effects of NAPLAN on stakeholder wellbeing and the impact on early years pedagogy and curriculum." Australasian Journal of Early Childhood 44, no. 3 (June 18, 2019): 309–20. http://dx.doi.org/10.1177/1836939119855562.

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National Assessment Program for Numeracy and Literacy (NAPLAN) is the national assessment programme for literacy and numeracy in Australia administered to children in Years 3, 5, 7 and 9 each year. The testing process was introduced in 2008 and is described by the developers as low stakes, however, research has highlighted that this is not the case. This paper examines the perceptions of teachers in the early years of school on the impact NAPLAN has on wellbeing of stakeholders, and the pedagogy and curriculum in early years teachers’ classrooms. Through focus group interviews, the early child

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Skröder, Helena, Maria Kippler, Fahmida Tofail, and Marie Vahter. "Early-Life Selenium Status and Cognitive Function at 5 and 10 Years of Age in Bangladeshi Children." Environmental Health Perspectives 125, no. 11 (November 2017): 117003. http://dx.doi.org/10.1289/ehp1691.

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Islam, Md Ashraful, Easnem Khanum, Md Rezaul Karim, Nelufa Tahera Rahman, and Md Rezaul Haque. "Effect of Spinal Anaesthesia in Children of 4-10 Years." Journal of Enam Medical College 7, no. 1 (January 30, 2017): 10–14. http://dx.doi.org/10.3329/jemc.v7i1.30744.

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Background: Though paediatric spinal anaesthesia has been used since early 20th century in developed countries even in neonates, still it is not common in our country. Spinal anaesthesia can be given in neonates and children for infraumbilical surgeries with an expert and experienced anaesthesiologist.Objective: The objective of this study was to establish spinal anaesthesia as a safe and effective regional anaesthetic procedure in children of 410 years.Materials and Methods: The study was done in the Department of Anaesthesiology & Intensive Care Unit of Enam Medical College & Hospit

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Haugeberg, Glenn, Pernille Bøyesen, Knut Helgetveit, and Anne Prøven. "Clinical and Radiographic Outcomes in Patients Diagnosed with Early Rheumatoid Arthritis in the First Years of the Biologic Treatment Era: A 10-year Prospective Observational Study." Journal of Rheumatology 42, no. 12 (November 15, 2015): 2279–87. http://dx.doi.org/10.3899/jrheum.150384.

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Objective.To study short-term and longterm clinical and radiographic outcomes in patients with early rheumatoid arthritis (RA) in the first decade of the biologic treatment era.Methods.Patients with early RA diagnosed at a rheumatology outpatient clinic were consecutively enrolled between 1999 and 2001. Data were collected on demographic characteristics, disease activity, patient-reported outcomes, and treatments. Radiographs of hands and feet were performed at baseline and after 2, 5, and 10 years and scored according to the Sharp/van der Heijde method, yielding a modified total Sharp score (

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Willard, Victoria W., Ibrahim Qaddoumi, Haitao Pan, Chia-Wei Hsu, Rachel C. Brennan, Matthew W. Wilson, Carlos Rodriguez-Galindo, Kristin Goode, Kendra Parris, and Sean Phipps. "Cognitive and Adaptive Functioning in Youth With Retinoblastoma: A Longitudinal Investigation Through 10 Years of Age." Journal of Clinical Oncology 39, no. 24 (August 20, 2021): 2676–84. http://dx.doi.org/10.1200/jco.20.03422.

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PURPOSE To describe the trajectory of cognitive and adaptive functioning in pediatric patients with retinoblastoma from diagnosis through age 10. This is an extension of a previous report that discussed findings from diagnosis through age 5. PATIENTS AND METHODS Ninety-eight participants with retinoblastoma completed psychological assessments as part of their enrollment on an institutional treatment protocol, with 73 completing an additional assessment at age 10. Trajectories of adaptive and cognitive functioning were determined, with data analyzed by treatment strata, and patients with 13q- a

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Srivastava, Sudhir. "The Early Detection Research Network: 10-Year Outlook." Clinical Chemistry 59, no. 1 (January 1, 2013): 60–67. http://dx.doi.org/10.1373/clinchem.2012.184697.

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BACKGROUND The National Cancer Institute's Early Detection Research Network (EDRN) has made significant progress in developing an organized effort for discovering and validating biomarkers, building resources to support this effort, demonstrating the capabilities of several genomic and proteomic platforms, identifying candidate biomarkers, and undertaking multicenter validation studies. In its first 10 years, the EDRN went from a groundbreaking concept to an operational success. CONTENTS The EDRN has established clear milestones for reaching a decision of “go” or “no go” during the biomarker d

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Gelley, Fanni, György Gámán, Zsuzsanna Gerlei, Gergely Zádori, Dénes Görög, László Kóbori, Imre Fehérvári, et al. "Hepatitis C virus recurrence after liver transplantation in Hungary. Trends over the past 10 years." Orvosi Hetilap 154, no. 27 (July 2013): 1058–66. http://dx.doi.org/10.1556/oh.2013.29647.

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Introduction: Management of hepatitis C virus recurrence is a challenge after liver transplantation. Aim: The aim of the authors was to analyse the outcome of liver transplantation performed in hepatitis C virus positive patients during the past ten years and to compare recent data with a previous report of the authors. Method: The authors retrospectively evaluated the data (donors, recipients, perioperative characteristics, patient and graft survival, serum titer of hepatitis C virus RNA, histology) of 409 patients who underwent liver transplantation between 2003 and 2012. Results: 156 patien

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Buchner, Thomas, Wolfgang E. Berdel, Bernhard J. Woermann, Maria Cristina Sauerland, Achim Heinecke, Utz Krug, and Wolfgang Hiddemann. "Up-Front Randomization 10 Years Later: The AML Cooperative Group Strategy." Blood 124, no. 21 (December 6, 2014): 2267. http://dx.doi.org/10.1182/blood.v124.21.2267.2267.

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Abstract As a global approach to acute myeloid leukemia the AMLCG started a clinical trial in 1999 with the intention to clarify the influence of baseline characteristics as well as treatment variables on patients’ outcome. The heterogeneity of this disease in mind, all randomization was done stratified for potential risk factors. Furthermore, all randomization was restricted to the single time point up-front of any treatment. Thus, an unbiased intention-to-treat analysis could be provided. Between June 1999 and January 2012, 3370 consecutive patients 16 - 86 (median 61) years of age entered t

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Kim, Jihye, Wonseok Kang, Dong Hyun Sinn, Geum-Youn Gwak, Yong-Han Paik, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, and Seung Woon Paik. "Substantial risk of recurrence even after 5 recurrence-free years in early-stage hepatocellular carcinoma patients." Clinical and Molecular Hepatology 26, no. 4 (October 1, 2020): 516–28. http://dx.doi.org/10.3350/cmh.2020.0016.

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Background/Aims: Although hepatocellular carcinoma (HCC) is notorious for its high recurrence rate, some patients do not experience recurrence for more than 5 years after resection or radiofrequency ablation for early-stage HCC. For those with five recurrence-free period, the risk of HCC recurrence within the next 5 years remains unknown.Methods: A total of 1,451 consecutive patients (median, 55 years old; males, 79.0%; hepatitis B virus-related, 79.3%) with good liver function (Child-Pugh class A) diagnosed with early-stage HCC by Barcelona Clinic Liver Cancer Staging and received radiofreque

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Mullin, T. J., and Y. S. Park. "Genetic parameters and age–age correlations in a clonally replicated test of black spruce after 10 years." Canadian Journal of Forest Research 24, no. 12 (December 1, 1994): 2330–41. http://dx.doi.org/10.1139/x94-301.

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Height growth at 10 years from striking was assessed for clonally replicated full-sib black spruce (Piceamariana (Mill.) B.S.P) families tested at three locations in central Nova Scotia. Variance components were interpreted according to an additive–dominance–epistasis genetic model and used to derive comparative estimates of gain from various selection and deployment strategies. Field performance at 5 and 10 years was compared with that of the original ortets and families growing in a 25-week greenhouse study, by means of phenotypic and genetic correlation, and rank-change analyses. Between ag

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Tse, Tao Sun Tycus, Yik-Cheung Samuel Wan, Kin-Ho Leo Leung, and Man-Kwan Wong. "Total knee arthroplasty: A single centre review at 10 years of follow-up." Journal of Orthopaedics, Trauma and Rehabilitation 27, no. 2 (June 22, 2020): 142–47. http://dx.doi.org/10.1177/2210491720928472.

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Background: Total knee arthroplasty is a common procedure for treatment of various non-infective arthritis. This study reviewed total knee arthroplasty cases up to 10 years of follow-up for the survival rate, reasons of revision and associated perioperative risk factors for revision. Methods: All cases to total knee arthroplasty performed in a single centre in the years 2007 and 2008 were reviewed. A total of 227 cases of total knee arthroplasty were performed during the 2-year period, with 156 cases followed up to 10 years. Perioperative information, follow-up information and information of p

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Zubrick, S. R., D. Lawrence, F. Mitrou, D. Christensen, and C. L. Taylor. "Early mental health morbidity and later smoking at age 17 years." Psychological Medicine 42, no. 5 (October 20, 2011): 1103–15. http://dx.doi.org/10.1017/s0033291711002182.

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BackgroundWe examined the relationship between the onset and pattern of childhood mental health disorders and subsequent current smoking status at age 17 years.MethodData were from a prospective cohort study of 2868 births of which 1064 supplied information about their current smoking at 17 years of age. The association between the onset and pattern of clinically significant mental health disorders in the child and subsequent smoking at age 17 years was estimated via multivariable logistic regression.ResultsRelative to 17 year olds who never had an externalizing disorder, 17-year-olds who had

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Hoff, M., G. Haugeberg, S. Ødegård, S. Syversen, R. Landewé, D. van der Heijde, and T. K. Kvien. "Cortical hand bone loss after 1 year in early rheumatoid arthritis predicts radiographic hand joint damage at 5-year and 10-year follow-up." Annals of the Rheumatic Diseases 68, no. 3 (March 13, 2008): 324–29. http://dx.doi.org/10.1136/ard.2007.085985.

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Objective:To examine 1-year hand bone loss in early rheumatoid arthritis (RA) as a predictor of radiographic damage at 5-year and 10-year follow-upMethods:A total of 136 patients with RA (disease duration 0–4 years) were followed for 10 years with clinical data and hand radiographs. Joint damage was scored according to the van der Heijde modification of the Sharp method (vdH Sharp score) and hand bone mineral density (BMD) was measured by digital x ray radiogrammetry (DXR). Group comparisons, correlation analyses and multivariate analyses were performed to evaluate the relationship between han

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Ciric, Jasmina, Milos Zarkovic, and Biljana Beleslin. "Fifty years of subclinical primary aldosteronism: Importance of early diagnosis." Srpski arhiv za celokupno lekarstvo 140, no. 11-12 (2012): 800–805. http://dx.doi.org/10.2298/sarh1212800c.

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Clinical presentation of excessive aldosterone secretion is often not specific. The presence of resistant severe hypertension (HT) and signs of hypokalemia is useful but inconsistent characteristic. Plasma aldosterone level in primary aldosteronism (PA) could be normal, although inappropriately high for a low plasma renin activity and not suppressed by sodium. Screening of hypertensive population with no obvious signs of PA has revealed an increased prevalence of idiopathic adrenal hyperplasia as a cause of aldosterone excess. Nowadays, PA is the most common endocrine form of secondary HT, wit

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Gurunathan, Deepa, Danalakshmi Jayachandar, and Ganesh Jeevanandan. "Prevalence of early loss of primary molars among children aged 5–10 years in Chennai: A cross-sectional study." Journal of Indian Society of Pedodontics and Preventive Dentistry 37, no. 2 (2019): 115. http://dx.doi.org/10.4103/jisppd.jisppd_22_19.

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Giuliani, J., A. Mercanti, and A. Bonetti. "Late recurrence (more than 10 years) in early (tumors equal to or smaller than 2 cm) breast cancer patients." Clinical and Translational Oncology 18, no. 8 (October 30, 2015): 859–62. http://dx.doi.org/10.1007/s12094-015-1433-5.

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DuMontier, Clark, Kerri Clough-Gorr, Rebecca A. Silliman, and André Moser. "Motivation and mortality in geriatric patients with early stage breast cancer." Journal of Clinical Oncology 33, no. 28_suppl (October 1, 2015): 105. http://dx.doi.org/10.1200/jco.2015.33.28_suppl.105.

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105 Background: Evidence suggests that an older patient’s motivation and life outlook are associated with health outcomes. A measure of motivation called the Getting Out of Bed Scale (GOB) was previously validated in a cohort of geriatric patients with early stage breast cancer. The aim of our project was to assess the association between GOB and mortality, both all-cause and breast-cancer specific, using the same dataset. Methods: We evaluated 660 women ≥ 65-years old diagnosed with stage I-IIIA primary breast cancer in four geographic regions in the US. Data were collected over ten-years of

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Rakhmawati, Nur Ika Sari, Rachma Hasibuan, and Erni Lutfiyah. "Study of Domino Number Game Development for Early Children’s Ability to Recognize Numbers." Jurnal Obsesi : Jurnal Pendidikan Anak Usia Dini 3, no. 2 (August 22, 2019): 578. http://dx.doi.org/10.31004/obsesi.v3i2.263.

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This study aims to develop and produce feasible and effective numerical domino game prototype used as learning to recognize symbols of number 1-10 for children aged 4-5 years. The design of study is research and development research adapted from Borg & Gall research and development using Single one shot case study and One Pretest-Posttest Design Group. But the writers used only 9 steps. The subject in this study are Group A children aged 4-5 years in 6 kindergartens in Duduk sampeyan Subdistrict, Gresik District. Data were analyzed using descriptive quantitative. The results of this develo

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Kavitha, Vanagondi K., Khetavath Gopal Singh, and Dundigalla Chandraiah. "Nutritional assessment in developmentally retarded children of 3-10 years age group." International Journal of Contemporary Pediatrics 6, no. 1 (December 24, 2018): 77. http://dx.doi.org/10.18203/2349-3291.ijcp20185087.

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Background: Intellectual disability is a condition of arrested or incomplete development of mind of a child and is specifically characterized by sub average intellectual functioning existing concurrently with limitations in conceptual, social, practical adaptive skills. Non-nutritional factors may influence growth, but nutritional factors such as insufficient calorie intake, excessive nutrient losses and abnormal energy metabolism also contribute to growth failure.Methods: A hospital based descriptive study was conducted where children with intellectual disability of 3 years to 10 years age gr

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Bertoli, Sarah, Suzanne Tavitian, Emilie Berard, Noemie Gadaud, Audrey Sarry, Francoise Huguet, Eric Delabesse, and Christian Recher. "More Than 10% of NPM1-Mutated AML Relapses Occur after 5 Years from Complete Remission." Blood 132, Supplement 1 (November 29, 2018): 2802. http://dx.doi.org/10.1182/blood-2018-99-113109.

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Abstract The majority of relapses in acute myeloid leukemia (AML) patients occur in the first or second year following complete remission. In routine, AML patients are followed during five years because few relapses can occur after three or five years. These late or very late relapses remain poorly described, particularly at the molecular level, with only few consistent series in the literature. (Medeiros B et al., Leuk Lymphoma 2007; Verma D et al., Leuk Lymphoma 2010; Watts J et al., Leuk Res 2014). We retrospectively studied all AML relapses occurring after complete remission (CR) obtained

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Schaefer, Peter R., and Norman W. Baer. "Stability of Ponderosa Pine Provenance Performance: Results after 21 Years in Eastern South Dakota." Northern Journal of Applied Forestry 9, no. 3 (September 1, 1992): 102–7. http://dx.doi.org/10.1093/njaf/9.3.102.

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Abstract Present seed source recommendations for ponderosa pine throughout most of the Great Plains are based on provenance data of trees up to 15 years old. There are indications in the literature that these recommendations may change as test plantations get older. Height and survival of 69 provenances of ponderosa pine were recorded 5, 10, 15, and 21 years following field establishment in 1968. The three provenances forming the north central Nebraska cluster maintained a significant height superiority over the remaining clusters at all measurement dates. Age/age correlations for total height

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Rodriguez-Muguruza, S., B. Combe, F. Guillemin, A. Olive, O. Valero, R. Fontova Garrofe, S. Marsal, F. Bruno, and C. Lukas. "POS0308 TRAJECTORIES OF FATIGUE IN EARLY RA OVER 10 YEARS: RESULTS FROM THE ESPOIR COHORT." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 380.1–380. http://dx.doi.org/10.1136/annrheumdis-2021-eular.214.

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Background:Fatigue is one of the most prevalent symptom reported by persons with RA. RA-related fatigue is a complex concept with biological, psychological and social interactions.Objectives:In a cohort of early RA patients, to determine and characterize fatigue trajectories over 10 years of follow-up and identify predictors of trajectory membership.Methods:Patients fulfilling the 2010 ACR/EULAR criteria for RA included in the ESPOIR cohort. We used a cluster analysis to obtain fatigue (assessed by fatigue visual analogue scale) trajectories over the course of 10 years from enrolment. Chi-squa

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Pfister, Hugo, Jane Lixin Dai, Marta Volonteri, Katie Auchettl, Maxime Trebitsch, and Enrico Ramirez-Ruiz. "Tidal disruption events in the first billion years of a galaxy." Monthly Notices of the Royal Astronomical Society 500, no. 3 (November 15, 2020): 3944–56. http://dx.doi.org/10.1093/mnras/staa3471.

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ABSTRACT Accretion of stars on massive black holes (MBHs) can feed MBHs and generate tidal disruption events (TDEs). We introduce a new physically motivated model to self-consistently treat TDEs in cosmological simulations, and apply it to the assembly of a galaxy with final mass $3\times 10^{10}\, \mathrm{M}_{\odot }$ at z = 6. This galaxy exhibits a TDE rate of $\sim 10^{-5}\, \mathrm{yr}^{-1}$, consistent with local observations but already in place when the Universe was one billion year old. A fraction of the disrupted stars participate in the growth of MBHs, dominating it until the MBH re

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Bhan, Alok, Cecilie Jacobsen, Kjell Morten Myhr, Ingvild Dalen, Kirsten Lode, and Elisabeth Farbu. "Neurofilaments and 10-year follow-up in multiple sclerosis." Multiple Sclerosis Journal 24, no. 10 (August 1, 2018): 1301–7. http://dx.doi.org/10.1177/1352458518782005.

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Background: The role of biomarkers to predict clinical outcome in multiple sclerosis (MS) is still debated. Objective: To test whether cerebrospinal fluid (CSF) light-chain neurofilament (NfL) levels in newly diagnosed patients with MS could predict clinical outcome over a 10-year period. Methods: Patients with newly diagnosed MS underwent standardized clinical assessments at baseline and 5 and 10 years of follow-up. Expanded Disability Status Scale (EDSS) progression between assessments was defined as an increase in one point or more if <6 and 0.5 or more if ≥6. CSF obtained at baseline wa

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Punglia, Rinaa S., Karen M. Kuntz, Eric P. Winer, Jane C. Weeks, and Harold J. Burstein. "Optimizing Adjuvant Endocrine Therapy in Postmenopausal Women With Early-Stage Breast Cancer: A Decision Analysis." Journal of Clinical Oncology 23, no. 22 (August 1, 2005): 5178–87. http://dx.doi.org/10.1200/jco.2005.02.964.

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Purpose The optimal adjuvant endocrine strategy for postmenopausal breast cancer is unknown. Options include the antiestrogen tamoxifen, estrogen deprivation with aromatase inhibitors, and sequential therapy with tamoxifen and then an aromatase inhibitor. Methods We developed Markov models to simulate 10-year disease-free survival among postmenopausal women with hormone receptor–positive breast cancer. The treatment strategies analyzed were 5 years of tamoxifen alone, 5 years of an aromatase inhibitor alone, and sequential treatment consisting of tamoxifen with cross over to an aromatase inhib

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Saarto, Tiina, Leena Vehmanen, Carl Blomqvist, and Inkeri Elomaa. "Ten-Year Follow-Up of 3 Years of Oral Adjuvant Clodronate Therapy Shows Significant Prevention of Osteoporosis in Early-Stage Breast Cancer." Journal of Clinical Oncology 26, no. 26 (September 10, 2008): 4289–95. http://dx.doi.org/10.1200/jco.2007.15.4997.

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PurposeWe have previously reported that 3-year adjuvant clodronate treatment prevents bone loss in breast cancer patients. Here we report the 10-year follow-up data of clodronate in the prevention of treatment-related osteoporosis in women with early-stage breast cancer.Patients and MethodsTwo hundred sixty-eight pre- and postmenopausal, node-positive breast cancer patients were randomly assigned to clodronate, 1.6 g orally administered daily, or to control groups for 3 years. Premenopausal women were treated with adjuvant CMF chemotherapy; and postmenopausal women were treated with antiestrog

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Stojakov, Dejan, Predrag Sabljak, Milos Bjelovic, M. Dunjic, B. Nenadic, K. Ebrahimi, B. Spica, et al. "Iatrogenicperforations of the esophagus and hypopharynx: 5 years experience of single institution." Acta chirurgica Iugoslavica 51, no. 1 (2004): 93–101. http://dx.doi.org/10.2298/aci0401093s.

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Iatrogenic perforations of the esophagus and hypopharynx are important problem, due to diagnostic difficulties, controversies about adequate treatment, and high morbidity and mortality rate. Incidence of iatrogenic perforations is from 50 to 75% of all perforations. In the period from April 1999. to April 2004, 15 patients with iatrogenic perforation of the esophagus and hypopharynx were treated at the Department of esophageal surgery, First University Surgical Hospital in Belgrade. In majority of patients iatrogenic perforation occured during endoscopie interventional procedure (endoscopie re

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Patterson, Brooke E., Adam G. Culvenor, Christian J. Barton, Ali Guermazi, Joshua J. Stefanik, Hayden G. Morris, Timothy S. Whitehead, and Kay M. Crossley. "Worsening Knee Osteoarthritis Features on Magnetic Resonance Imaging 1 to 5 Years After Anterior Cruciate Ligament Reconstruction." American Journal of Sports Medicine 46, no. 12 (September 4, 2018): 2873–83. http://dx.doi.org/10.1177/0363546518789685.

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Background: An anterior cruciate ligament (ACL) injury is a well-established risk factor for the long-term development of radiographic osteoarthritis (OA). However, little is known about the early degenerative changes (ie, <5 years after injury) of individual joint features (ie, cartilage, bone marrow), which may be reversible and responsive to interventions. Purpose: To describe early degenerative changes between 1 and 5 years after ACL reconstruction (ACLR) on magnetic resonance imaging (MRI) and explore participant characteristics associated with these changes. Study Design: Case-control

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Mikhaylovskiy, M. N., V. V. Novikov, A. S. Vasyura, V. N. Sarnadskiy, and L. G. Kuz'mishcheva. "SOVREMENNAYa KONTsEPTsIYa RANNEGO VYYaVLENIYa I LEChENIYa IDIOPATIChESKOGO SKOLIOZA." N.N. Priorov Journal of Traumatology and Orthopedics 10, no. 1 (March 15, 2003): 3–10. http://dx.doi.org/10.17816/vto20031013-10.

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Concept of early detection and treatment of patients with idiopathic scoliosis is presented. That concept has been elaborated at Novosibirsk Institute of Traumatology and Orthpaedics (Republican Center of spine pathology) and includes the following stages. 1. Screening of large groups of children for early diagnosis of spine deformities using computer optic tomography. 2. Follow up of children from the "risk groups". 3. Conservative treatment of children with deformities within 20-40° by Cobb using jacket elaborated at Novosibirsk. 4. Surgical treatment of progressive deformities with individu

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Gercovich, N., E. Gil Deza, M. Russo, C. Garcia Gerardi, C. Diaz, E. Morgenfeld, B. Rolnik, J. Emina, E. Rivarola, and F. G. Gercovich. "Early-stage male breast cancer: A 10-year experience." Journal of Clinical Oncology 27, no. 15_suppl (May 20, 2009): e11630-e11630. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e11630.

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e11630 Introduction: Male breast cancer is very rare, representing only between 0.7% and 1% of all breast cancers, and only half of them are early stage cases. Objective: The present study has been designed with the aim of studying retrospectively the clinical onset and evolution of male invasive breast cancer patients (stages I and II) treated at IOHM between 1997 and 2008. Methods: The records of 3,000 breast cancer cases followed between 1997 and 2008 were searched, looking for male stage I and II breast cancer patients. A database was designed following the recommendations of the Directors

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Fitzgerald, Kelly, and Adil Daud. "Response to PD-1 inhibition in early- and late-relapsing cutaneous melanoma." Journal of Clinical Oncology 37, no. 15_suppl (May 20, 2019): e21038-e21038. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e21038.

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e21038 Background: Up to 45% of stage I-II melanomas will relapse within 5 years, and some relapses occur more than 10 years after surgical resection. Little is known about the differences in tumor characteristics, including immunogenicity, of early- vs. late-relapsing melanoma, or the implication of these differences in response to PD-1 inhibition. Methods: A retrospective cohort study was conducted to compare time from definitive treatment of localized melanoma to relapse with response to pembrolizumab. Patients with prior stage I-II melanoma who relapsed, and then treated with pembrolizumab

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Goss, Paul E., James N. Ingle, Kathleen I. Pritchard, Nicholas J. Robert, Hyman Muss, Julie Gralow, Karen A. Gelmon, et al. "A randomized trial (MA.17R) of extending adjuvant letrozole for 5 years after completing an initial 5 years of aromatase inhibitor therapy alone or preceded by tamoxifen in postmenopausal women with early-stage breast cancer." Journal of Clinical Oncology 34, no. 18_suppl (June 20, 2016): LBA1. http://dx.doi.org/10.1200/jco.2016.34.18_suppl.lba1.

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LBA1 Background: Five years of aromatase inhibitor (AI) therapy either as up-front treatment or after 2-5 years of tamoxifen has become the standard of care for postmenopausal women with hormone receptor positive early breast cancer. Extending treatment with an AI to 10 years may further reduce the risk of breast cancer recurrence. Methods: We conducted a double-blind, placebo-controlled trial (Canadian Cancer Trials Group MA.17R) to test the efficacy of extending AI treatment for an additional five years using letrozole. The primary endpoint was disease-free survival. Results: A total of 1,91

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Grant, Valerie V., Alexa L. Bagnell, Christine T. Chambers, and Sherry H. Stewart. "Early Temperament Prospectively Predicts Anxiety in Later Childhood." Canadian Journal of Psychiatry 54, no. 5 (May 2009): 320–30. http://dx.doi.org/10.1177/070674370905400506.

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Objective: To investigate the contribution of early childhood temperamental constructs corresponding to 2 subtypes of general negative emotionality—fearful distress (unadaptable temperament) and irritable distress (fussy–difficult temperament)—to later anxiety in a nationally representative sample. Method: Using multiple linear regression analyses, we tested the hypothesis that caregiver-reported child unadaptable temperament and fussy–difficult temperament scales of children aged 2 to 3 years (in 1995) would prospectively predict caregiver-reported child anxiety symptoms at ages 4 to 5, 6 to

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Fickett, Nathanael D., Chris M. Boerboom, and David E. Stoltenberg. "Soybean Yield Loss Potential Associated with Early-Season Weed Competition across 64 Site-Years." Weed Science 61, no. 3 (September 2013): 500–507. http://dx.doi.org/10.1614/ws-d-12-00164.1.

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Glyphosate applied POST can provide a high level of efficacy on many weed species in soybean, but delayed application beyond optimal weed growth stages might fail to fully protect yield potential. Further, we do not have a good understanding of the extent to which delayed glyphosate application and its associated yield loss is occurring on-farm. Our goal was to characterize on-farm weed communities in glyphosate-resistant soybean just prior to glyphosate application and estimate potential yield loss associated with early-season soybean-weed competition. In field surveys conducted across 64 sit

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Jeremic, Branislav, Yuta Shibamoto, Ljubisa Acimovic, Nebojsa Nikolic, Aleksandar Dagovic, Jasna Aleksandrovic, and Gordana Radosavljevic-Asic. "Second Cancers Occurring in Patients With Early Stage Non–Small-Cell Lung Cancer Treated With Chest Radiation Therapy Alone." Journal of Clinical Oncology 19, no. 4 (February 15, 2001): 1056–63. http://dx.doi.org/10.1200/jco.2001.19.4.1056.

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PURPOSE: To investigate the incidence of second cancers occurring in patients with early stage (I/II) non–small-cell lung cancer (NSCLC) treated with radiation therapy (RT) alone.PATIENTS AND METHODS: Seventy-eight patients had been treated with conventionally fractionated (CF) RT (1982 to 1987), and 116 patients had been treated with hyperfractionated (Hfx) RT (1988 to 1993). Tumor doses were 60 Gy for CF and 69.6 Gy (1.2 Gy bid) for Hfx.RESULTS: A total of 26 patients developed second cancers. The cumulative incidence of second cancer was 21.8% (SE, 4.7%) at 5 years and 34.8% (SE, 6.7%) at 1

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Dar, Hanief Mohamed, Tariq Ahmed Mala, Yaqoob Hassan, Shahid Amin Malla, Mir Mujtaba Ahmad, and Varun Dogra. "Penile fracture; three years’ experience from a tertiary care centre." International Surgery Journal 5, no. 2 (January 25, 2018): 553. http://dx.doi.org/10.18203/2349-2902.isj20180350.

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Background: To study cause, presentation, diagnosis and early management of penile fracture and to prevent the complications.Methods: In this study 48 patients of penile fracture were included in the study who were admitted in general surgery department at Government Medical College Srinagar from May 2007 to May 2010. All patients were evaluated with detailed history, clinical examination and baseline investigations followed by immediate surgical repair.Results: Age range of patients was 21-75 years. Youngest being 21 years and eldest being 75 years (median-30 years). 38(79.1%) patients were m

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Falch-Madsen, Jonas, Lars Wichstrøm, Ståle Pallesen, and Silje Steinsbekk. "Prevalence and stability of insomnia from preschool to early adolescence: a prospective cohort study in Norway." BMJ Paediatrics Open 4, no. 1 (June 2020): e000660. http://dx.doi.org/10.1136/bmjpo-2020-000660.

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BackgroundThere is limited knowledge about the prevalence and stability of insomnia defined by the Diagnostic and Statistical Manual of Mental Disorders (DSM). We therefore provide such estimates from preschool to early adolescence and explore potential sex differences.MethodsWe followed a representative community sample (n=1037) biennially from 4 to 14 years of age (2007–2017). Insomnia diagnoses and symptoms were captured by a semistructured clinical interview of parents and children (from age 8 years).ResultsAt ages 4 and 6 years approximately 2.5% of children met the criteria for insomnia,

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Kawalec, Anna, and Krystyna Pawlas. "Breakfast Frequency and Composition in a Group of Polish Children Aged 7–10 Years." Nutrients 13, no. 7 (June 29, 2021): 2241. http://dx.doi.org/10.3390/nu13072241.

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Breakfast is considered one of the crucial elements of a healthy diet. Most studies evaluate breakfast consumption with the risk of obesity and other health effects. Less attention is paid to the evaluation of breakfast composition and patterns. Thus, this study aimed to describe the most frequently observed breakfast patterns and to assess breakfast composition and quality in a group of Polish early school-age children. The cross-sectional survey study was conducted in school years 2017/2018 and 2018/2019. Information regarding breakfast was obtained with the use of an original paper-based we

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Nofiyanto, Muhamat, Muhamad Munif, and Miftafu Darussalam. "PENGETAHUAN DAN SIKAP PERAWAT TENTANG MOBILISASI DINI PASIEN DI ICU RSUD PANEMBAHAN SENOPATI BANTUL YOGYAKARTA." MEDIA ILMU KESEHATAN 6, no. 1 (November 11, 2019): 9–17. http://dx.doi.org/10.30989/mik.v6i1.173.

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Background: Early mobilization is necessary in critically ill patients in Intensive Care Unit (ICU) to prevent hypovolemia which endangers patient’s life. The role of nurses in early mobilization is important by providing explanations and motivating patients to achieve the purpose of healing. Guidance and intensive intervention from nurses can reduce the recurrence of disease. Objective: To investigate the level of knowledge and attitude of nurses on patients early mobilization in ICU of RSUD Panembahan Senopati Bantul. Method: A descriptive, cross sectional study, was applied on 2

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Demirag, M. Kemal, Hasan Tahsin Keçeligil, and Fersat Kolbakir. "Primary Surgical Repair of Ventricular Septal Defect." Asian Cardiovascular and Thoracic Annals 11, no. 3 (September 2003): 213–16. http://dx.doi.org/10.1177/021849230301100307.

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Between January 1983 and December 2000, 78 patients underwent primary repair of a ventricular septal defect. There were 42 males (54%) and 36 females (46%) of whom 13 (17%) were under 1 year old, 50 (64%) were aged 1–10 years, 11 (14%) were aged 10–20 years, and 4 (5%) were over 20 years old. The ventricular septal defect was a perimembranous type in 60 patients (77%), subarterial (outlet) type in 10 (13%), and atrioventricular canal (inlet) type in 4 (5%). Operative repair was performed with a patch in all except 2 patients. Early postoperative complications included insignificant aortic regu

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