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Dissertations / Theses on the topic 'Elastic tissue'

Author: Grafiati

Published: 4 June 2021

Last updated: 30 July 2024

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1

Wang, Ziyu. "Development of electrospun tropoelastin-polyglycerol sebacate scaffolds for soft tissue engineering applications." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/27880.

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Soft tissue damages from disease, trauma, and ageing often have limited regeneration capability, leading to the loss of tissue functions and impacting the quality of life. Repair tissue damage using polymeric materials can alleviate issues such as donor shortage and transplantation rejection associated with undesirable immune responses. This project developed tropoelastin-polyglycerol sebacate (tropelastin-PGS) scaffolds with a spectrum of 3D microstructures, tuneable mechanical properties, controllable degradation profile, and excellent biocompatibility suitable for diverse soft tissue applic

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2

Ferron, Florence Joelle. "The implications of fibulin-5 on elastin assembly and its role in the elastic fiber /." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101846.

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The extracellular matrix (ECM) is the material found surrounding the cells in a tissue. One component of the ECM is the elastic fiber, which confers the property of elasticity to its environment. Organs such as the lung, skin and major blood vessels have an abundance of elastic fibers so that they are able to expand and recoil. Elastic fibers are composed of two main components; elastin and microfibrils. Microfibrils are composed primarily of fibrillin-1 and provide a scaffold unto which tropoelastin monomers assemble. Elastic fibers interact with many other proteins in the ECM, one of which i

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Hyder, Safeer. "Ultrasound based soft tissue elastic modulus and strain measurement." Thesis, University of Leeds, 2017. http://etheses.whiterose.ac.uk/18279/.

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Conventional B-mode ultrasound provides information on the anatomical features using acoustic impedance differences in the tissues. Ultrasound elastography uses a variety of techniques to map soft tissue elasticity. Tissue stiffness is a novel indicator of the tissue health, as many pathologies can alter the tissue stiffness such as cancer and fibrosis. Accurate and early detection of tissue elasticity can guide towards reliable diagnosis, and prognosis of diseases. The objectives of the research reported in this thesis are to implement strain and shear wave elastography techniques on the loca

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Grant, Tyler M. "Microstructural deformation of tendon." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:0ad70415-af7a-4b97-a93a-d17a73d8ff44.

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Tendon disorders are painful, disabling, and a major healthcare problem, with millions of people affected by tendon injuries each year. Current treatment strategies are inadequate and knowledge of the underlying mechanobiological mechanisms is required to develop novel therapies. Although the tissue–level properties of tendon are well–documented there remains a lack of understanding of the deformation mechanisms of this complex tissue. Therefore, the aim of this thesis is to characterize the microstructural deformation of tendon through biological imaging, mechanical testing, and computational

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Shankara, Bhanu Fricke Brian A. "Determination of the elastic properties of cardiac tissue using scanning acoustic microscopy." Diss., UMK access, 2006.

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Thesis (M.S.)--School of Computing and Engineering. University of Missouri--Kansas City, 2006.<br>"A thesis in mechanical engineering." Typescript. Advisor: Brian A. Fricke. Vita. Title from "catalog record" of the print edition Description based on contents viewed Jan. 29, 2007. Includes bibliographical references (leaves 69-70). Online version of the print edition.

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6

Pascoe, Katie Clare, and n/a. "Heritable and early life growth factors affect arterial elastic tissue defect formation." University of Otago. Dunedin School of Medicine, 2006. http://adt.otago.ac.nz./public/adt-NZDU20070306.160709.

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A German pathologist first described defects in the elastic tissues of human arteries over one hundred years ago. Much evidence now supports the involvement of these elastic tissue defects (ETDs) in the initiation and progression of atherosclerosis, although this association is not well accepted. Recent research has determined that the migration of medial smooth muscle cells into the intima (and therefore the start of the atherosclerotic process) is initiated in an attempt to repair these defects and in addition, that there is a correlation between the extent of intimal thickening and the degr

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7

Aghaei-Ghareh-Bolagh, Behnaz. "Development of elastic biomaterials as high performance candidates for tissue engineering applications." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/18789.

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Tropoelastin is an extracellular matrix protein, which polymerises to form elastin in the body. Due to its distinctive structural, mechanical and biological properties, tropoelastin provides a versatile building block for manufacturing biomaterials applicable to tissue engineering. Silk fibroin is a fibrous protein that has been widely used in biomedical applications because of its strength and durability. Hybrid protein polymers comprised of recombinant human tropoelastin and silk fibroin have favourable characteristics as implantable scaffolds in terms of mechanical and biological properties

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8

Dahal, Shataakshi. "Stem Cells Based Elastic Matrix Regeneration for Small Abdominal Aortic Aneurysms (AAAs) Repair." Cleveland State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=csu1599137475237285.

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9

Dahal, Shataakshi. "Stem Cells Based Elastic Matrix Regeneration for Small Abdominal Aortic Aneurysms (AAAs) Repair." Cleveland State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=csu1599137475237285.

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10

Anderson, Courtney Rae. "The Rate of Intramuscular Tissue Temperature Reduction Between Wetted Ice with Elastic Wrap and Game Ready®." Thesis, North Dakota State University, 2020. https://hdl.handle.net/10365/31747.

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In recent years, the Game Ready® unit has become a popular cryotherapy modality to treat musculoskeletal injuries. The purpose of this study was to determine which cryotherapy method, wetted ice bag with elastic wrap or Game Ready®, decreases triceps surae intramuscular tissue temperature the most during a 30-minute treatment. The independent variables were the cryotherapy modalities (Game Ready® and wetted ice with elastic wrap) and time (baseline, 10, 20, and 30 minutes). Twenty patients participated in this study. Wetted ice with elastic wrap decreased tissue temperatures significantly grea

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11

Ling, Yuting. "Elastic characterization of ex vivo human prostate tissue using vibration optical coherence elastography and second harmonic generation microscopy." Thesis, University of Dundee, 2018. https://discovery.dundee.ac.uk/en/studentTheses/4c4f7057-aaf5-43b0-89c9-dc948e2698dc.

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12

Swaminathan, Ganesh. "Evaluation Of Adult Stem Cell Derived Smooth Muscle Cells For Elastic Matrix Regenerative Repair." University of Akron / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=akron1462209321.

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13

Jalkanen, Ville. "Tactile sensing of prostate cancer : a resonance sensor method evaluated using human prostate tissue in vitro." Doctoral thesis, Umeå : Department of Applied Physics and Electronics, Umeå Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1445.

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MURALIDHARAN, PRASANNA. "FINITE DEFORMATION BIPHASIC MATERIAL CHARACTERIZATION AND MODELING OF AGAROSE GEL FOR FUNCTIONAL TISSUE ENGINEERING APPLICATIONS." University of Cincinnati / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1148319031.

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15

Iori, Gianluca. "Micro-FEM models based on micro-CT reconstructions for the in vitro characterization of the elastic properties of trabecular bone tissue." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amslaurea.unibo.it/5422/.

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This master’s thesis describes the research done at the Medical Technology Laboratory (LTM) of the Rizzoli Orthopedic Institute (IOR, Bologna, Italy), which focused on the characterization of the elastic properties of the trabecular bone tissue, starting from october 2012 to present. The approach uses computed microtomography to characterize the architecture of trabecular bone specimens. With the information obtained from the scanner, specimen-specific models of trabecular bone are generated for the solution with the Finite Element Method (FEM). Along with the FEM modelling, mechanical test

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Jobeili, Lara. "Évolution de modèles tridimensionnels de peau reconstruite pour approfondir la connaissance des mécanismes du vieillissement cutané et validation de l’efficacité « anti-âge » du sélénium." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1044/document.

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La peau et son vieillissement sont un enjeu de santé publique. Les modèles expérimentaux disponibles pour l'étude du vieillissement cutané restent perfectibles. Dans ce contexte, nos objectifs étaient simultanément d'utiliser les modèles de peaux reconstruites (PR) développés dans notre laboratoire afin i) de mieux comprendre les mécanismes du vieillissement cutané, ii) de démontrer l'efficacité et le mécanisme d'action du sélénium comme « anti âge » et enfin iii) de les faire évoluer en utilisant le support poreux ou auto-assemblé avec des fibroblastes du même donneur prélevés à des âges diff

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Sgarbi, Flávia Celina [UNESP]. "Histomorfometria das fibras colágenas e das fibras do sistema elástico da queilite actínica e sua relação com os níveis de atipia." Universidade Estadual Paulista (UNESP), 2006. http://hdl.handle.net/11449/87942.

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Made available in DSpace on 2014-06-11T19:23:04Z (GMT). No. of bitstreams: 0 Previous issue date: 2006-08-01Bitstream added on 2014-06-13T20:49:55Z : No. of bitstreams: 1 sgarbi_fc_me_sjc.pdf: 1257619 bytes, checksum: e8d58cf54222cb30a853c958e6bbefd1 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>A Queilite Actínica (QA) é uma lesão cancerizável, intimamente relacionada com a exposição solar crônica sobre os lábios que pode evoluir para o carcinoma espinocelular. Os achados histológicos de atipia no tecido epitelial são freqüentes, embora subjetivos. A lâmina

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Sgarbi, Flávia Celina. "Histomorfometria das fibras colágenas e das fibras do sistema elástico da queilite actínica e sua relação com os níveis de atipia /." São José dos Campos : [s.n.], 2006. http://hdl.handle.net/11449/87942.

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Orientador: Ana Sueli Rodrigues Cavalcante<br>Banca: Ana Lia Albinder<br>Banca: Yasmin Rodarte Carvalho<br>Resumo: A Queilite Actínica (QA) é uma lesão cancerizável, intimamente relacionada com a exposição solar crônica sobre os lábios que pode evoluir para o carcinoma espinocelular. Os achados histológicos de atipia no tecido epitelial são freqüentes, embora subjetivos. A lâmina própria subjacente apresenta uma alteração basofílica acelular e amorfa, conhecida como elastose solar e degeneração basofílica do colágeno. O melhor meio de prevenção é evitar a exposição constante aos raios solares.

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Fink, Gisele Miozzo. "Estudo da distribuição diferencial das fibras do sistema elástico no ventrículo esquerdo do coração de ratos normais." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-16062009-162743/.

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A elasticidade do tecido conjuntivo desempenha uma função protetora agindo como uma mola tênsil durante o trabalho muscular, No entanto, existem poucos estudos sobre a distribuição das fibras do sistema elástico no coração. Considerando que: a) o estudo da distribuição destas fibras pode ajudar a compreender a mecânica cardíaca, e b) o rato tem sido usado como o melhor modelo animal para as disfunções cardiovasculares, o objetivo deste estudo é apresentar uma descrição sistemática da distribuição diferencial das fibras do sistema elástico do endocárdio, epicárdio e miocárdio ventricular. Corte

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20

Nita, Luciana Miwa. "Estudo histoquímico e ultra-estrutural da distribuição das fibras da matriz extracelular na prega vocal humana fetal no período perinatal." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5143/tde-29052008-093547/.

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Acredita-se que nos humanos, o ligamento vocal se desenvolva após o nascimento. No entanto, não há consenso na literatura sobre qual a faixa etária de seu aparecimento. Muitos estudos indicam que no neonato, a lâmina própria da prega vocal apresenta-se com algumas fibras esparsas sem uma organização particular. O principal objetivo deste estudo foi obter informação a respeito das fibras colagênicas e do sistema elástico (sob a luz dos conhecimentos atuais sobre a matriz extracelular), na lâmina própria de pregas vocais de fetos no período perinatal. Laringes obtidas por autópsia de fetos entre

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21

Patriota, Regia Celli Ribeiro. "Estudo comparativo pré e pós luz intensa pulsada no tratamento do fotoenvelhecimento cutâneo: avaliação clínica, histopatológica e imunoistoquímica." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5133/tde-10092009-115612/.

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Introdução: A luz intensa pulsada(LIP) tem sido muito utilizada no tratamento do fotoenvelhecimento sem completo conhecimento de seu mecanismo de ação. Métodos: Foram acompanhados 26 pacientes apresentando fotoenvelhecimento grau II-III (GLOGAU, 1994), os quais foram submetidas à avaliação clínica , histológica e imunoistoquímica 6 e 12 meses após o término do tratamento com LIP. Foram realizadas cinco sessões com intervalos de trinta dias. Além da quantificação histomorfométrica das fibras colágenas e elásticas na derme, foram avaliados CD1, CD4, CD8 e ICAM-1. Resultados: Após 6 meses houve m

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22

Gemmer, John Alan. "Shape Selection in the Non-Euclidean Model of Elasticity." Diss., The University of Arizona, 2012. http://hdl.handle.net/10150/223311.

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In this dissertation we investigate the behavior of radially symmetric non-Euclidean plates of thickness t with constant negative Gaussian curvature. We present a complete study of these plates using the Föppl-von Kármán and Kirchhoff reduced theories of elasticity. Motivated by experimental results, we focus on deformations with a periodic profile. For the Föppl-von Kármán model, we prove rigorously that minimizers of the elastic energy converge to saddle shaped isometric immersions. In studying this convergence, we prove rigorous upper and lower bounds for the energy that scale like the thic

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23

Sakae, Flavio Akira. "Distribuição das fibras colágenas e do sistema de fibras elásticas na camada superficial da lâmina própria da prega vocal com edema de Reinke." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5143/tde-31102008-173147/.

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A fisiopatologia do edema de Reinke ainda permanece desconhecida e poucos estudos abordam sobre as alterações das proteínas fibrosas, colágeno e elastina, na matriz extracelular da prega vocal com edema de Reinke. Por isso, este estudo foi idealizado para descrever a distribuição das fibras colágenas e do sistema de fibras elásticas do espaço de Reinke com edema de Reinke comparando com a prega vocal normal e com a severidade do edema. Foram obtidas 20 amostras de pregas vocais de indivíduos com edema de Reinke, sendo nove casos com edema de Reinke grau II e 11 casos grau III. Dezessete indiví

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Ramos, Helena Hotz Arroyo. "Estudo histológico dos efeitos agudos de lesão com laser de diodo 980 nm em pregas vocais de coelhos." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5143/tde-09052018-090014/.

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INTRODUÇÃO: A cicatriz em prega vocal que ocorre após injúria constitui causa importante de disfonia. A fonocirurgia ideal é aquela em que a lesão efetivamente removida com o menor dano possível ao tecido adjacente, a fim de reestabelecer a função da prega vocal ao mesmo tempo em que a sua ultraestrutura sua ultraestrutura é preservada. Tanto o bisturi frio quanto lasers em geral são aceitos como instrumentos para fonocirurgia. O laser de diodo tem sido usado no tratamento de doenças laríngeas. Entretanto, não há consenso quanto os parâmetros ideais desse aparelho para tal finalidade. Inexiste

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Rosenstrauch, Doreen. "Use of autologous auricular chondrocytes for lining left ventricular assist devices." Doctoral thesis, [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972610480.

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Vieira-Damiani, Gislaine 1976. "Análise computacional de fibras elásticas e colágenas da aorta humana." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310249.

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Orientadores: Konradin Metze, Carlos Lenz Cesar<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-21T10:46:07Z (GMT). No. of bitstreams: 1 Vieira-Damiani_Gislaine_D.pdf: 4044155 bytes, checksum: 7a862a3866981d1827845318ce37b121 (MD5) Previous issue date: 2012<br>Resumo: A hipertensão arterial sistêmica (HAS) bem como o envelhecimento provoca mudanças na estrutura dos grandes vasos sanguíneos - aorta e seus ramos - propiciando o desenvolvimento de processos degenerativos que são a causa de diversas doenças. O uso de f

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27

Nejjar, Ibtissam. "Etude morphologique et biochimique du tissu elastique de l'aorte thoracique humaine lors du vieillissement et de l'atherosclerose." Toulouse 3, 1988. http://www.theses.fr/1988TOU30154.

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Tavares, Raquel Aguiar. "Estudo histológico da matriz extracelular do músculo cricofaríngeo em cadáveres de diferentes idades." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5143/tde-24022010-155855/.

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O músculo cricofaríngeo desempenha um importante papel na deglutição. Acredita-se que seu comportamento elástico seja dependente não apenas do componente muscular, mas também do tecido conectivo intramuscular. O objetivo desse estudo foi analisar a presença e a distribuição do colágeno total, colágenos tipo I e III, fibras elásticas, fibronectina e versican no endomísio do músculo cricofaríngeo em cadáveres de diferentes idades. Vinte e sete músculos foram obtidos mediante autópsia de indivíduos de ambos os sexos com idades entre 28 e 92 anos. Foram realizadas colorações histoquímicas, Método

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Lundström, Jonathan, and Joel Skagersten. "Optimering samt implementering av Harts automatiserade färgningsmetod : Ersättning av Verhoeffs manuella elastinfärgning." Thesis, Jönköping University, HHJ, Avd. för naturvetenskap och biomedicin, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-52932.

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Elastinfibrer ger blodkärl och andra vävnader deras flexibilitet. Elastinfärgning är relevant när man misstänker melanom, temporalis artrit, venös invasion och efter blodkärlsoperationer. Syftet var att med hjälp av olika vävnadstyper optimera och implementera den automatiserad elastinfärgningen enligt Hart, för att ersätta den nuvarande manuella elastinfärgning enligt Verhoeff vid patologilaboratoriet på länssjukhuset Ryhov, Jönköping. Colon, njure, hud samt navelsträng färgades med den automatiska metoden enligt Hart för att hitta optimala inställningar. Vävnader från samma områden färgades

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Patel, Dhaval Pradipkumar. "Novel PEG-elastin copolymer for tissue engineered vascular grafts." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/45811.

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The growing incidences of coronary artery bypass graft surgeries have triggered a need to engineer a viable small diameter blood vessel substitute. An ideal tissue engineered vascular graft should mimic the microenvironment of a native blood vessel, while providing the adequate compliance post-implantation. Current vascular graft technologies lack the ability to promote vascular ECM deposition, leading to a compliance mismatch and ultimately, graft failure. Hence, in order to engineer suitable vascular grafts, this thesis describes the synthesis and characterization of novel elastin mimetic pe

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Annoni, Raquel. "Composição da matriz extracelular na doença pulmonar obstrutiva crônica." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5144/tde-24052011-132145/.

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A doença pulmonar obstrutiva crônica (DPOC) é caracterizada por inflamação crônica e alterações estruturais que levam a obstrução das pequenas vias aéreas e destruição do parênquima alveolar. A composição da matriz extracelular (MEC) nos pulmões tem um importante papel em prover e sustentar a arquitetura pulmonar. No entanto, não há uma descrição abrangente da composição da matriz extracelular no trato respiratório de indivíduos portadores de DPOC. No presente estudo investigou-se a composição da MEC das vias aéreas grandes (VAG), pequenas (VAP) e do parênquima pulmonar de pacientes com DPOC.

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Ravi, Swathi. "Recombinant elastin analogues as cell-adhesive matrices for vascular tissue engineering." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/42728.

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Biomimetic materials that recapitulate the complex mechanical and biochemical cues in load-bearing tissues are of significant interest in regenerative medicine and tissue engineering applications. Several investigators have endeavored to not only emulate the mechanical properties of the vasculature, but to also mimic the biologic responsiveness of the blood vessel in creating vascular substitutes. Previous studies in our lab generated the elastin-like protein polymer LysB10, which was designed with the capability of physical and chemical crosslinks, and was shown to display a range of elastome

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Trejo, Miguel. "Theoretical studies of fluid and elastic membranes." Paris 6, 2009. http://www.theses.fr/2009PA066698.

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Cette thèse est consacrée à l'étude théorique des membranes fluides, comme les vésicules lipidiques, et des membranes élastiques comme les tissus vivants. Nous avons utilisé des méthodes alliant calcul variationnel et géométrie différentielle des surfaces pour décrire les divers aspects mécaniques et topologiques de ces objets et leur influence sur leur comportement physique et biologique. Dans une première partie nous avons abordé le problème de la tension de ligne entre deux domaines qui composent une vésicule inhomogène. A partir d'un modèle modifiant la description habituelle de ces membra

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Beekman, Anneke. "The Next Step For A Collagen-Elastin Dermal Template In Skin Tissue Engineering." Thesis, The University of Sydney, 2019. http://hdl.handle.net/2123/21092.

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Background MatriDerm, a collagen-elastin dermal template, is commonly used in full-thickness wound repair, to promote dermal regeneration and improve scar tissue quality. Due to the non-cross-linked status, it is expected to biodegrade relatively quickly. Cross-linking the collagen-elastin template could potentially enhance its performance. Aim The aim of this study was to investigate the effects of cross-linking on MatriDerm stability, cell interaction, biodegradation and wound contraction using established cell culture and murine models. Method MatriDerm was cross-linked with glutaraldehyde

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Kinikoglu, Fatma Beste. "Tissue engineering of full-thickness human oral mucosa." Thesis, Lyon 1, 2010. http://www.theses.fr/2010LYO10310.

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L’ingénierie de la muqueuse orale humaine (MOH) a pour but le comblement des pertes de substances suite à un traumatisme facial ou à la chirurgie des lésions malignes. Elle a aussi des applications en recherche pour élucider les mécanismes biologiques de la MO et en pharmacotoxicologie comme alternative à l’expérimentation animale. L'objectif de cette thèse était de reconstruire une MOH proche du tissu normal. À cette fin, la faisabilité du concept a d'abord été testée par co-culture de fibroblastes de la lamina propria et de cellules épithéliales de MOH dans le substrat de collagène-chitosan

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Broiles, JoSette Leigh Briggs. "The use of a tissue engineered media equivalent in the study of a novel smooth muscle cell phenotype." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/22652.

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Thesis (Ph. D.)--Mechanical Engineering, Georgia Institute of Technology, 2008.<br>Committee Chair: Nerem, Robert; Committee Member: Chaikof, Elliot; Committee Member: Taylor, W. Robert; Committee Member: Vito, Raymond; Committee Member: Wight, Thomas.

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Rohan, Christian Pierre-Yves. "Etude biomécanique de l’action des Bas Médicaux de Compression sur les parois veineuses du membre inférieur." Thesis, Saint-Etienne, EMSE, 2013. http://www.theses.fr/2013EMSE0721/document.

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La compression élastique est la thérapeutique conservatrice la plus efficace pour la prise en charge de l'insuffisance veineuse et pour le traitement de la maladie veineuse chronique et de ses complications. Malheureusement, en pratique, les objectifs thérapeutiques ne sont pas toujours atteints ce qui souligne le manque de connaissance actuel concernant les mécanismes qui permettent aux Bas Médicaux de Compression (BMC) d'apporter les bienfaits thérapeutiques. Pour apporter des éléments de réponse, une étude numérique de l’action des BMC sur les veines a été réalisée. Dans un premier temps, u

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Mäki, J. (Joni). "Lysyl oxidases:cloning and characterization of the fourth and the fifth human lysyl oxidase isoenzymes, and the consequences of a targeted inactivation of the first described lysyl oxidase isoenzyme in mice." Doctoral thesis, University of Oulu, 2002. http://urn.fi/urn:isbn:9514267397.

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Abstract Lysyl oxidases (EC 1.4.3.13, protein-lysine 6-oxidases) are extracellular copper enzymes that initiate the cross-linking of collagens and elastin by catalyzing oxidative deamination of the ε-amino group in certain lysine and hydroxylysine residues. The cross-links formed are responsible for the tensile strength of collagen fibers and the unique elastic properties of elastin. Three human lysyl oxidase isoenzymes, lysyl oxidase (LOX), lysyl oxidase-like protein (LOXL), and lysyl oxidase-like 2 protein (LOXL2), have been identified and characterized so far. Two additional human lysyl o

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Zhao, Xuefeng. "Pointwise identification of elastic properties in nonlinear heterogeneous membranes, and application to soft tissues." Diss., University of Iowa, 2009. https://ir.uiowa.edu/etd/222.

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Identifying the elastic properties of heterogeneous materials has long been a very challenging problem both theoretically and experimentally. When it comes to biological tissues, this task is even more difficult since biological tissues generally exhibit substantial anisotropic behavior. Moreover, identification is often required to be performed in the service condition of living human tissues and organs, i.e., in vivo. Presently, a method capable of performing such tasks is lacking. The primary goal of this study is to fill this gap by developing a novel experimental method, termed as pointwi

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Kinikoglu, Beste F. "Tissue Engineering Of Full-thickness Human Oral Mucosa." Phd thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/12612770/index.pdf.

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Tissue engineered human oral mucosa has the potential to fill tissue deficits caused by facial trauma or malignant lesion surgery. It can also help elucidate the biology of oral mucosa and serve as an alternative to in vivo testing of oral care products. The aim of this thesis was to construct a tissue engineered full-thickness human oral mucosa closely mimicking the native tissue. To this end, the feasibility of the concept was tested by co-culturing fibroblasts and epithelial cells isolated from normal human oral mucosa biopsies in a collagen-glycosaminoglycan-chitosan scaffold, developed in

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Walton, Lucy Anne. "From molecules to tissues : characterising the relationship between structure and function in ageing arteries." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/from-molecules-to-tissues-characterising-the-relationship-between-structure-and-function-in-ageing-arteries(b06aab9a-6845-41d2-ac97-0aac85e71e1a).html.

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Increased arterial stiffness is a predictor of cardiovascular events and mortality across a diverse range of populations. Although gross-mechanical stiffness can be measured in vivo, in order to understand the pathological mechanisms it will be necessary to identify which local micro-structural remodelling events are the prime drivers of altered macro-mechanical function. However, characterisation of arterial structure by conventional histological approaches: i) commonly induces artefacts as a consequence of the sectioning process, ii) provides no insight into the three dimensional structure o

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Harrington, Christine. "The Prevalence of Pseudoxanthoma Elasticum-like Connective Tissue Changes in an Oral Biopsy Service." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1308062343.

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Silva, Patricia Angeli da. "Efeitos da inibição crônica das óxido nítrico sintases na mecânica de tecido periférico, no recrutamento eosinofílico e no remodelamento da matriz extracelular induzida por inflamação crônica pulmonar." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-25032009-140404/.

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INTRODUÇÃO: A importância da resposta mecânica do parênquima pulmonar na fisiopatologia da asma tem sido recentemente reconhecida. O óxido nítrico é um mediador que controla o tônus muscular liso das vias aéreas, porém este efeito no parênquima pulmonar periférico ainda não foi previamente investigado. Nossa hipótese é que a inibição crônica das óxido nítrico sintases por meio do tratamento com L-NAME (falso substrato para todas as óxido nítrico sintases) pode modular a mecânica do parênquima pulmonar, o recrutamento eosinofílico e o remodelamento da matriz extracelular em modelo de inflamação

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Kurane, Aditee. "Vascular tissue engineering the creation of living, non-thrombogenic, functional blood vessels based on elastin scaffolds /." Connect to this title online, 2008. http://etd.lib.clemson.edu/documents/1239895754/.

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Kumar, Vivek Ashok. "Design and evaluation of scaffolds for arterial grafts using extracellular matrix based materials." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/45869.

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For small diameter (<6 mm) blood vessel replacements, lack of collaterals and vascular disease preclude homografts; while synthetic analogs, ePTFE, expanded polytetrafluoroethylene, and PET, polyethyleneterephathalate, are prone to acute thrombosis and restenosis. It is postulated that the hierarchical assembly of cell populated matrices fabricated from protein analogs provides a new design strategy for generating a structurally viable tissue engineered vascular graft. To this end, synthetic elastin and collagen fiber analogs offer a novel strategy for creating tissue engineered vascular graft

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Wintrich, Sahithya. "Elastogenic characterization of rat BM-MSC-derived SMCS towards use in soft Tissue Engineering." Cleveland State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=csu1351784707.

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Berglund, Joseph Delore. "Elastin and viscoelasticity in cell-seeded collagen constructs cultured in virto : implications for tissue-engineered blood vessels." Diss., Georgia Institute of Technology, 2002. http://hdl.handle.net/1853/11722.

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La, Joie Elaine Naomi. "Tissue welding : studies of pulsed diode laser interaction with ICG stained porcine aorta and elastin-based biomaterial /." Full text open access at:, 1995. http://content.ohsu.edu/u?/etd,249.

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Caforio, Federica. "Mathematical modelling and numerical simulation of elastic wave propagation in soft tissues with application to cardiac elastography." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLX001/document.

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Les objectifs de cette thèse sont la modélisation mathématique et la simulation numérique de l’élastographie impulsionnelle basée sur la force de radiation acoustique (FRA) dans un tissu mou précontraint, et en particulier le myocarde. La première partie du manuscript concerne la modélisation mathématique de la FRA, la propagation d’ondes de cisaillement qui en résulte et la caractérisation de la vitesse des ondes de cisaillement pour une loi de comportement générale du tissu myocardique. Nous montrons aussi des applications pour l’estimation de l’orientation des fibres cardiaques dans le myoc

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Frauziols, Fanny. "Elastographie ultrasonore des tissus mous du membre inférieur en vue de la caractérisation des effets mécaniques de dispositifs médicaux textiles." Thesis, Saint-Etienne, EMSE, 2015. http://www.theses.fr/2015EMSE0809/document.

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La compression élastique de la jambe est le traitement de référence des pathologies liées à l’insuffisance veineuse. Bien que l’efficacité ne soit plus à prouver, les objectifs thérapeutiques restent non atteints pour certains patients. Un objectif de la compression élastique est la réduction de la pression pariétale des veines afin de rétablir ou d’augmenter le retour du sang vers le cœur par une transmission de pression au travers des tissus mous. Ce mécanisme est complexe et peut être prédit par des modèles éléments finis personnalisés. Pour être personnalisés, ces modèles doivent prendre e

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