Relevant bibliographies by topics / Endogenous melatonin

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  2. Dissertations / Theses
  3. Book chapters

Academic literature on the topic 'Endogenous melatonin'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Endogenous melatonin"

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Reiter, Russel J., Sergio Rosales-Corral, and Ramaswamy Sharma. "Melatonin: Protection of the Intervertebral Disc." Melatonin Research 2, no. 3 (2019): 1–9. http://dx.doi.org/10.32794/mr11250028.

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Low back pain (lumbar pain) due to injury of or damage to intervertebral discs is common in all societies. The loss of work time as a result of this problem is massive. Recent research suggests that melatonin may prevent or counteract intervertebral disc damage. This may be especially relevant in aging populations given that endogenous melatonin, in most individuals, dwindles with increasing age. The publications related to melatonin and its protection of the intervertebral disc are reviewed herein, including definition of some molecular mechanisms that account for melatonin’s protective actio
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LI, Beibei, Hongjian ZHANG, Mohammed AKBAR, and Hee-Yong KIM. "Negative regulation of cytosolic phospholipase A2 by melatonin in the rat pineal gland." Biochemical Journal 351, no. 3 (2000): 709–16. http://dx.doi.org/10.1042/bj3510709.

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In this paper evidence that supports a new role for melatonin as a negative endogenous regulator of cytosolic phospholipase A2 (cPLA2) is presented. When rat pineal glands were incubated in culture, time-dependent release of arachidonic acid (AA) was observed, which was significantly inhibited by a known 85-kDa cPLA2 inhibitor, methyl arachidonyl fluorophosphonate. Co-incubation with melatonin inhibited the AA release in a concentration-dependent manner, and this decrease was accompanied by a reduction of cPLA2 protein and mRNA expression. Melatonin-receptor agonists, 2-iodo-N-butanoyl-5-metho
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Tang, Kuo-Shu, Chun-Yi Ho, Chien-Ning Hsu, and You-Lin Tain. "Melatonin and Kidney Health: From Fetal Stage to Later Life." International Journal of Molecular Sciences 24, no. 9 (2023): 8105. http://dx.doi.org/10.3390/ijms24098105.

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Melatonin, an endogenous hormone mainly released at night by the pineal gland, has multifaceted biofunctions. Emerging evidence points to melatonin having a crucial role in kidney health and disease. As the prevalence of chronic kidney disease (CKD) is still rising, a superior strategy to advance global kidney health is needed to not just treat CKD, but prevent it early on. Adult kidney disease can have its origins in early life. This review aims to evaluate the recent literature regarding melatonin’s effect on kidney development, its clinical uses in the early stage of life, animal models doc
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Moretti, Enrico, Gaia Favero, Luigi Fabrizio Rodella, and Rita Rezzani. "Melatonin’s Antineoplastic Potential Against Glioblastoma." Cells 9, no. 3 (2020): 599. http://dx.doi.org/10.3390/cells9030599.

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Glioblastoma (GBM) is one of the most intransigent and aggressive brain tumors, and its treatment is extremely challenging and ineffective. To improve patients’ expectancy and quality of life, new therapeutic approaches were investigated. Melatonin is an endogenous indoleamine with an incredible variety of properties. Due to evidence demonstrating melatonin’s activity against several cancer hallmarks, there is growing interest in its use for preventing and treating cancer. In this review, we report on the potential effects of melatonin, alone or in combination with anticancer drugs, against GB
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Sohn, Eun-Hwa, Su-Nam Kim, and Sung-Ryul Lee. "Melatonin’s Impact on Wound Healing." Antioxidants 13, no. 10 (2024): 1197. http://dx.doi.org/10.3390/antiox13101197.

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Melatonin (5-methoxy-N-acetyltryptamine) is an indoleamine compound that plays a critical role in the regulation of circadian rhythms. While melatonin is primarily synthesized from the amino acid tryptophan in the pineal gland of the brain, it can also be produced locally in various tissues, such as the skin and intestines. Melatonin’s effects in target tissues can be mediated through receptor-dependent mechanisms. Additionally, melatonin exerts various actions via receptor-independent pathways. In biological systems, melatonin and its endogenous metabolites often produce similar effects. Whil
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Yang, Xiaoxiao, Qifeng Shi, Xinru Wang, et al. "Melatonin-Induced Chromium Tolerance Requires Hydrogen Sulfide Signaling in Maize." Plants 13, no. 13 (2024): 1763. http://dx.doi.org/10.3390/plants13131763.

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Both melatonin and hydrogen sulfide (H2S) mitigate chromium (Cr) toxicity in plants, but the specific interaction between melatonin and H2S in Cr detoxification remains unclear. In this study, the interaction between melatonin and H2S in Cr detoxification was elucidated by measuring cell wall polysaccharide metabolism and antioxidant enzyme activity in maize. The findings revealed that exposure to Cr stress (100 μM K2Cr2O7) resulted in the upregulation of L-/D-cysteine desulfhydrase (LCD/DCD) gene expression, leading to a 77.8% and 27.3% increase in endogenous H2S levels in maize leaves and ro
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Hodzic, Elvisa, Milica Balaban, Nevena Suskalo, Semira Galijasevic, Dino Hasanagic, and Biljana Kukavica. "Antioxidative response of Melissa officinalis L. and Valeriana officinalis L. leaves exposed to exogenous melatonin and excessive zinc and cadmium level." Journal of the Serbian Chemical Society 84, no. 1 (2019): 11–25. http://dx.doi.org/10.2298/jsc180504070h.

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Heavy metals disturb the redox homeostasis of the plant cell. The indolamine hormone, melatonin, protects plants from oxidative damage by directly scavenging reactive oxygen species or by stimulating the activity of antioxidant enzymes. The antioxidative role of melatonin in the leaves of two medicinal plants, lemon balm (Melissa officinalis L.) and valerian (Valeriana officinalis L.) that were treated with increased concentrations of Zn and Cd 24 h after sowing at an open field, were investigated. The plants were treated with Zn, Cd, melatonin and a mixture of melatonin with the mentioned met
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Claustrat, Bruno, Jocelyne Brun, Martine Geoffriau, and Guy Chazot. "Melatonin: From the Hormone to the Drug?" Restorative Neurology and Neuroscience 12, no. 2-3 (1998): 151–57. https://doi.org/10.3233/rnn-1998-00031.

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Melatonin (MLT) is a methoxyindole secreted principally by the pineal gland. It is synthesized at night under normal environmental conditions. The endogenous rhythm of secretion is generated by the suprachiasmatic nuclei and entrained by the light/dark cycle. Light is able to both suppress or synchronize melatonin production according to the light schedule. The nycthohemeral rhythm of this hormone is determined by repeated measurement of plasma of saliva MLT or urine sulfatoxymelatonin, the main hepatic metabolite. Melatonin can be considered as the output (the hand) of the endogenous clock. S
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Aashish1, Ravi Kumar Yadav2. "Role of the pineal gland, endogenous opioids and neuropeptides in reproduction." Vet Farm Frontier 02, no. 02 (2025): 65–69. https://doi.org/10.5281/zenodo.15014297.

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T he pineal governs or participates in the command of many bodily functions by means of its endocrine action, using mechanisms and physiological correlations that are presently not fully explained. Investigations in both animals and humans have provided evidence that the gland plays an important role in the regulation of both the circadian and seasonal rhythms in a variety of species (Masson Pevet and Gauer,1994). It recently was shown that the gland has a significant role in regulating the seasonal reproductive behaviors of animals that breed seasonally. Primarily in follicular growth, melato
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Boatright, Jeffrey H., Nara M. Rubim, and P. Michael Iuvone. "Regulation of endogenous dopamine release in amphibian retina by melatonin: The role of GABA." Visual Neuroscience 11, no. 5 (1994): 1013–18. http://dx.doi.org/10.1017/s0952523800003941.

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AbstractIn the retina of the African clawed frog (Xenopus laevis), endogenous dopamine release increases in light and decreases in darkness. Exogenous melatonin and several chemical analogs of melatonin suppressed light-evoked dopamine release from frog retina in a concentration-dependent manner. The rank order of potency for inhibition of light-evoked dopamine release was melatonin » 5-methoxytryptamine ≥ N-acetylserotonin > 5-methoxytryptophol ⋙ serotonin. Melatonin did not suppress dopamine release below levels seen in darkness. The putative melatonin receptor antagonist luzindole inhibi
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Dissertations / Theses on the topic "Endogenous melatonin"

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Sallinen, P. (Pirkko). "Myocardial infarction:aspects relating to endogenous and exogenous melatonin and cardiac contractility." Doctoral thesis, University of Oulu, 2008. http://urn.fi/urn:isbn:9789514287558.

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Abstract Melatonin is an important modulator of several physiological and behavioural processes, and it influences the function of many different tissues. Melatonin has effective antioxidative properties, but some of its actions in mammals are also mediated through the MT1 and MT2 melatonin receptors. Antioxidative properties are seen especially when the melatonin concentration is high (≥ nM), and melatonin's affinity for its receptors appears at lower concentrations (pM). Recently, the involvement of melatonin in protecting the heart against cardiac diseases, including myocardial infarction (
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Herrero, Ramón María Jesús. "Ritmos de actividad motora, comportamiento alimentario e influencia de la melatonina exógena en peces teleósteos." Doctoral thesis, Universidad de Murcia, 2007. http://hdl.handle.net/10803/10856.

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La presente Tesis Doctoral tiene como objetivo profundizar en los conocimientos sobre ritmos biológicos y comportamiento alimentario de tres especies de peces teleósteos de interés en acuicultura: tenca (Tinca tinca), trucha alpina (Salvelinus alpinus) y lubina (Dicentrarchus labrax).Con este fin se ha investigado la influencia de factores bióticos y abióticos en la sincronización de los ritmos de actividad locomotora y alimentaria, así como el carácter endógeno y/o exógeno de estos ritmos. A su vez, se ha profundizado en el comportamiento individual de truchas alpinas mantenidas en grupo, med
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Γουρνή, Δέσποινα. "Ενδογενείς παράγοντες με άμεση επίδραση στην αγγειογένεση". Thesis, 2007. http://nemertes.lis.upatras.gr/jspui/handle/10889/661.

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Η αγγειογένεση ρυθμίζει πολλές φυσιολογικές και παθολογικές διαδικασίες. Έτσι είναι μεγάλου ενδιαφέροντος να ανακαλυφθούν μηχανισμοί που συμμετέχουν. Στο πρώτο μέρος της μεταπτυχιακής εργασίας πραγματοποιήθηκε η σύνθεση των τριών πεπτιδίων, ανάλογα ΤR1-41). Στην συνέχεια μελετήθηκε ο βιολογικός ρόλος του ΤR1-41. Είναι γνωστό ότι η θρομβίνη, η πρωτεάση σερίνης, έχει κεντρικό ρόλο στην αιμόσταση, και έχει προταθεί για να διαδραματίσει έναν σημαντικό ρόλο στην έναρξη της αγγειογέννεσης μέσω της μεταγωγής σήματος από τους PARs υποδοχέων. Οι PARs αποτελούνται μια νέα οικογένεια πρωτεϊνικών υ
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Book chapters on the topic "Endogenous melatonin"

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Wirz-Justice, Anna, Francesco Benedetti, and Michael Terman. "Endogenous and Exogenous Melatonin." In Chronotherapeutics for Affective Disorders. KARGER, 2009. http://dx.doi.org/10.1159/000210073.

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Lewy, Alfred J., Robert L. Sack, Mary L. Blood, Vance K. Bauer, Neil L. Cutler, and Katherine H. Thomas. "Melatonin Marks Circadian Phase Position and Resets the Endogenous Circadian Pacemaker in Humans." In Novartis Foundation Symposia. John Wiley & Sons, Ltd., 2007. http://dx.doi.org/10.1002/9780470514597.ch15.

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Uba, Abdullahi Ibrahim, Atif Khurshid Wani, and Sani Sharif Usman. "Melatonin and Postharvest Biology of Fruits and Vegetables: Augmenting the Endogenous Molecule by Exogenous Application." In Plant in Challenging Environments. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-40173-2_9.

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"Endogenous and Exogenous Melatonin." In Chronotherapeutics for Affective Disorders. KARGER, 2013. http://dx.doi.org/10.1159/000188344.

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Goel, Ms Neha. "Endogenous Antioxidants-III." In Edited Book of Dietary Supplements and Nutraceuticals [According to latest syllabus of B. Pharm-VIII Semester of Pharmacy Council of India]. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/nbennurdsch14.

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Endogenous antioxidants are critical components of the body’s defense system against oxidative stress, with Vitamin E, α-lipoic acid, and melatonin playing pivotal roles in maintaining cellular health and preventing damage. Vitamin E is a fat-soluble antioxidant that primarily protects cell membranes from oxidative damage by neutralizing free radicals. It is particularly effective in safeguarding lipids from peroxidation, thereby supporting skin health, immune function, and reducing the risk of chronic diseases such as cardiovascular disease. α-Lipoic acid is a versatile antioxidant that is bo
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Albreiki, Mohammed. "Characteristic, synthesis, and non-photic regulation of endogenous melatonin." In Melatonin - Recent Updates [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.106574.

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Several researchers have confirmed that the melatonin hormone is significant to the body’s circadian rhythm, hence, the need to explore the connection between the two aspects. The circadian rhythm is a natural endogenous process that controls essential body functions as it affects hormone release, body temperature, sleep patterns, and eating habits. In that view, the circadian rhythm relies on melatonin to synchronize the night and day cycles. Melatonin plays a significant role in controlling the circadian rhythm by facilitating quality sleep at night and alertness during the day. In effect, u
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Solís-Chagoyán, Héctor, Jairo Muñoz-Delgado, Rosa Estrada-Reyes, Salvador Alarcón-Elizalde, and Gloria Benítez-King. "Circadian Modulation of Neurodevelopment in the Adult Human Brain: Importance of Melatonin." In Circadian Rhythm - New Insights Into the Physiological and Pathological Implications [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.102859.

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Melatonin (N-acetyl-5-methoxytryptamine) is an indoleamine synthesized by the pineal gland in the dark phase of the photoperiod. Released melatonin into the pineal recess and the cerebrospinal fluid is the chemical signal that conveys information about the environmental illumination to the brain. In recent years, it was described that melatonin stimulates the neurodevelopment in the adult brain. During this complex process, new neurons are formed and differentiate to form synaptic connections. Neuropsychiatric disorders are characterized by the loss of neuronal connectivity and diminished leve
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Aulinas, Anna, Cristina Colom, and Susan M. Webb. "Pineal physiology and pathophysiology, including pineal tumours." In Oxford Textbook of Endocrinology and Diabetes. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199235292.003.2222.

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The pineal gland is innervated mainly by sympathetic nerve fibres that inform the gland of the prevailing light-dark cycle and acts as a neuroendocrine transducer. The gland is located behind the third ventricle in the centre of the brain and is a highly vascular organ formed by neuroglial cells and parenchymal cells or pinealocytes. The latter synthesize melatonin as well as other indoleamines and peptides. The main pineal hormone melatonin (N-acetyl-5-methoxytryp-tamine) exhibits an endogenous circadian rhythm, reflecting signals originating in the suprachiasmatic nucleus; environmental ligh
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Arendt, J., and Timothy M. Cox. "The pineal gland and melatonin." In Oxford Textbook of Medicine, edited by Mark Gurnell. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198746690.003.0262.

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The pineal gland transduces light–dark cycles for the timing of body rhythms by secretion of melatonin, an endogenous indoleamine derived from tryptophan, the concentrations of which in plasma and cerebrospinal fluid are up to 100 times higher at night than in the daytime. This exerts its effects through transmembrane, G-protein coupled receptors (MT1 and MT2), and nuclear receptors primarily in the suprachiasmatic nucleus, pars tuberalis of the pituitary gland and hypothalamus. The natural period of the human circadian system is on average 24.1 to 24.3 h, and the principal resetting agent is
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Haldar, Chandana, and Jayita Pal Chowdhury. "Chronodisruption and Loss of Female Reproductive Potential Due to Shift Work." In Research Anthology on Advancements in Women's Health and Reproductive Rights. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-6684-6299-7.ch032.

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Entrainment of 24 hrs light/dark cycle is nowadays getting altered in corporate sector and even at home due to over exposure to artificial light at night (ALAN) and is commonly denoted as chronodisruption. Chronodisruption interferes with the daily physiology that is regulated by SCN/pineal-melatonin/Hypothalamo-Pituitary axis. In females, reduction in sleep due to shift work desynchronizes HPG-HPA axis induces a stress like condition, accompanied by increased free radical generation in ovary leading to polycystic ovaries, depletion of ovarian reserve, luteal phase defects, endometriosis, impl
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