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Dissertations / Theses on the topic 'Endometrial cance'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

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1

Čaplakova, V., E. Blahovcova, E. Babušíkova, and J. Hatok. "Molecular analysis of apoptosis related genes DNA methylation status in endometrial carcinogenesis." Thesis, Сумський державний університет, 2016. http://essuir.sumdu.edu.ua/handle/123456789/44939.

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Aberrant methylation in the promoters of genes associated with apoptosis was observed in many human cancers, but in the context of endometrial cancer only few publications have described the DNA methylation status of these genes. Apoptosis is a program cell death to maintain a tissue homeostasis in normal menstrual cycle. Disturbances in this pathway can promote cancer cell survival and furthermore are associated with resistance to therapy in endometrial cancer. Despite a high curability of this cancer type, prognosis of patients with advanced disease is still poor. One of the major mechanism

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2

Wang, Yiying, Yue Wang, Jie Li, et al. "Lynch syndrome related endometrial cancer: clinical significance beyond the endometrium." BioMed Central, 2013. http://hdl.handle.net/10150/610184.

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Lynch syndrome (LS), an autosomal dominant inherited cancer susceptibility syndrome, also known as hereditary non-polyposis colon cancer (HNPCC), is caused by a germline mutation in one of several DNA mismatch repair (MMR) genes. LS is the most common presentation of hereditary colorectal cancer (CRC), accounting for about 2-5% of all CRC cases. More recently, it is found that a similar number of endometrial cancers is also due to one of the MMR gene mutations. There has been significant progress in LS-related CRC in terms of molecular pathogenesis, risks, genetic basis, and cancer prevention.

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3

Gatius, Calderó Sònia. "Alteracions metabolòmiques en el càncer d'endometri." Doctoral thesis, Universitat de Lleida, 2020. http://hdl.handle.net/10803/668709.

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El càncer d’endometri és la neoplàsia ginecològica més freqüent en els països desenvolupats. Malgrat que la majoria dels carcinomes són curables amb un tractament adequat, al voltant del 20% dels tumors es comporten de forma agressiva i suposen un repte terapèutic. És per aquest motiu que sorgeix la necessitat d’identificar nous paràmetres per tal de seleccionar pacients amb risc de recidiva o metàstasi. La cèl•lula eucariota presenta canvis en el seu metabolisme com a resposta coordinada a diferents situacions fisiològiques i patològiques, entre elles el càncer. L’anàlisi del metaboloma, mit

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4

Dowdy, Janet A. "Effects of acetaminophen on estrogen-responsive alkaline phosphatase in Ishikawa endometrial cancer cells." Morgantown, W. Va. : [West Virginia University Libraries], 2000. http://etd.wvu.edu/templates/showETD.cfm?recnum=1565.

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Thesis (M.S.)--West Virginia University, 2000.<br>Title from document title page. Document formatted into pages; contains vii, 79 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 68-79).

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5

Simón, Coll Marta. "Aportación de la ecografía tridimensional en el diagnóstico del cáncer de endometrio." Doctoral thesis, Universitat Autònoma de Barcelona, 2021. http://hdl.handle.net/10803/672073.

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L’objectiu d’aquesta Tesis constisteix en demostrar l’aportació que fa l’ecografia tridimensional a l’estudi del Càncer d’Endometri, tant en el diagnòstic com en la determinació de la infiltració miometrial i cervical. La importància ve donada per la implicació terapèutica especialment pel que fa a la valoració de la infiltració miometrial. L’aplicabilitat dels resultats queda patent amb la bona eficàcia diagnòstica de l’ ecografia 3D en el càncer d’endometri, tant en el diagnòstic, com en la valoració de la infiltració miometrial i cervical, amb l’avantatge de ser una prova de fàcil aplicaci

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6

Tonon, Ângela Favorito Santarém [UNESP]. "Claudina-3 e Claudina- 4, potenciais marcadores de agressividade no carcinoma endometrial Tipo I." Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/108608.

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Made available in DSpace on 2014-08-13T14:50:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-08-12Bitstream added on 2014-08-13T18:00:34Z : No. of bitstreams: 1 000758246.pdf: 1669883 bytes, checksum: ace7f36bd830a8ef0026e86e6c1f9acb (MD5)<br>O Carcinoma de Endométrio é a neoplasia epitelial maligna que acomete mulheres no pré, pós e peri -menopausa. Segundo diferenças endócrinas, metabólicas, fatores de risco e morfologia é classificado em dois grandes grupos: Tipo I (endometrióide) e Tipo II (não endometrióide). O Tipo I perfaz 90 % dos carcinomas de endométrio e sua patogenia es

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7

Bergadà, Bertran Laura. "Estudi dels efectes antineoplàsics del tractament amb Vorinostat, Vitamina D i radioteràpia en el càncer d’endometri." Doctoral thesis, Universitat de Lleida, 2013. http://hdl.handle.net/10803/272933.

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El carcinoma d'endometri (CE) és la neoplàsia més freqüent del tracte genital femení en els països desenvolupats. El CE és una malignització de les cèl·lules epitelials que revesteixen l'úter en el seu interior. Tot i que quan està confinat l’úter té bon pronòstic, quan surt de la cavitat uterina es torna una malaltia pràcticament incurable, per la qual cosa requereix la recerca de nous fàrmacs. La identificació de noves dianes terapèutiques a més dels mecanismes moleculars d’actuació d’aquests fàrmacs en aquesta neoplàsia, té una gran rellevància translacional. Si es compara amb els tractamen

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8

Cheng, Timothy. "Genetic susceptibility to endometrial cancer." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:3a559ae0-156f-48a2-a64e-b03a13c562df.

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Endometrial cancer (EC) is the fourth most common cancer affecting women in the UK. Those with a family history of EC have an increased risk compared with the general population. Highly penetrant germline mutations in mismatch repair (MMR) genes and DNA polymerases account for only a small proportion of the familial aggregation. The aim of this thesis is to investigate the genetic susceptibility to EC in the general population using cases and controls of European ancestry. A GWAS meta-analysis totalling 7,737 EC cases and 37,144 controls yielded five novel EC risk loci of genome-wide significa

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9

Kho, Pik Fang. "Genetic epidemiology of endometrial cancer." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/211383/1/Pik%20Fang_Kho_Thesis.pdf.

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Endometrial cancer is the fifth most common cancer diagnosed in women in developed countries. This research used genetics to assess relationships between endometrial cancer and, previously identified and novel, risk factors. This work brings new insights by providing evidence that HDL and LDL cholesterol levels are linked to endometrial cancer risk. Further, I have shown that two gynaecological diseases, which are comorbid with endometrial cancer, also share genetic risk architecture with endometrial cancer. This work also advances the understanding of biological mechanisms of endometrial canc

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10

Peres, Gustavo Filipov [UNESP]. "Investigação da evolução dos pólipos endometriais em câncer de endométrio." Universidade Estadual Paulista (UNESP), 2015. http://hdl.handle.net/11449/132035.

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Made available in DSpace on 2015-12-10T14:23:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-02-27. Added 1 bitstream(s) on 2015-12-10T14:29:26Z : No. of bitstreams: 1 000849048.pdf: 1022160 bytes, checksum: c08754783f76207caeff18437f29cb15 (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Objetivo: Avaliar a expressão imunoistoquímica de receptores de estrogênio (RE) e progesterona (RP), de proteínas relacionadas à proliferação celular (Ki-67), à neoangiogênese (endoglina - CD105), à adesão celular (claudinas 3 e 4) e proteínas da matriz extracelular (metal

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11

Chen, Maxine M. "Genetics and Genomics of Endometrial Cancer." Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:27201719.

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Endometrial cancer (EC) is the most common gynecological cancer among women in the developed world and is hypothesized to arise from excess estrogen exposure from established risk factors like estrogen-only hormone therapy and obesity. EC is divided into the common “estrogen-dependent” endometrioid subtype and the rare “estrogen-independent” non- endometrioid subtype. However, this broad categorization of EC is not sufficient based on evidence for EC heterogeneity. Furthermore, family history and hereditary syndromes also increase risk, suggesting a genetic component. This dissertation examine

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12

Falck, Eva. "Genomic Alterations in Experimental Endometrial Adenocarcinoma." Licentiate thesis, Högskolan i Skövde, Institutionen för vård och natur, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-7419.

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13

Devis, Jauregui Laura. "The role of activated leukocyte cell adhesion molecule (ALCAM) in endometrial cancer progression and dissemination." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/403809.

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El carcinoma endometrial (CE) es el tumor infiltrante más común del tracto genital femenino y el cuarto en la mujer en países desarrollados, siendo la tipología endometrioide (CEE) la más frecuente. El 80% de las pacientes son diagnosticadas cuando el tumor sigue localizado en el útero, presentado una supervivencia a los 10 años que alcanza el 80%. Sin embargo, un número pequeño aunque relevante de estas pacientes recurren. Por ello, es de vital importancia encontrar marcadores para predecir la recidiva en esas pacientes para las cuales no se conoce un factor de riesgo suficientemente robusto.

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14

魏燕萍 and Yin-ping Ngai. "p21-activated kinases in endometrial carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B40738528.

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15

Campoy, Moncayo Irene. "Exosomes in uterine aspirates: characterization and identification of diagnostic and prognostic biomarkers in endometrial cancer." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/458138.

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El càncer d’endometri (CE) és la malaltia del tracte genital femení més freqüent als EE.UU i ocupa la quarta posició del rànquing de càncers més comuns en dones. Malauradament, les morts per CE estan augmentant ràpidament i les taxes van incrementar un 2% anual del 2010 al 2014. Tot i que els tumors confinats dins l’úter i diagnosticats precoçment representen un 67% dels casos i presenten un supervivència als 5 anys d’un 95%, resta un 30% dels casos diagnosticats en estadis avançats de la malaltia que presenten una davallada dràstica en la taxa de supervivència a 5 anys (69% i 17% pels casos a

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16

Wedrén, Sara. "Genetic susceptibility to breast and endometrial cancer /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-053-2/.

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17

鄧國全 and Kwok-tsuen Dang. "Methylation status of endometrial cancer related genes." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31970497.

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18

Nickkho-Amiry, Mahshid. "Peroxisome proliferator-activated receptors in endometrial cancer." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/peroxisome-proliferatoractivated-receptors-in-endometrial-cancer(2388ac43-ecd4-402f-a9c7-853be4902ec8).html.

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Endometrial cancer is a common gynaecological cancer. Improving outcomes for women with advanced disease remains a challenge and there is also a need to develop preventative strategies in those women at highest risk of developing disease. Peroxisome proliferator-activated receptors (PPARs) comprise of a group of transcription factors belonging to the nuclear hormone receptor subfamily. PPAR sub-types are involved in metabolic homeostasis and have been implicated in malignancy, particularly breast and colo-rectal malignancies both of which are associated with obesity. Endometrial cancer is also

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19

Dang, Kwok-tsuen. "Methylation status of endometrial cancer related genes." Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25549583.

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20

陳君怡 and Kwan-yi Queeny Chan. "Molecular studies on endometrial and ovarian carcinogenesis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39634474.

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21

Naftalin, J. G. "Ultrasound studies of the endometrial-myometrial junction for the diagnosis of adenomyosis and endometrial cancer." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1432603/.

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This thesis investigated the ultrasound assessment of the endometrial-myometrial junction (EMJ) and its clinical relevance to the uterine diseases, adenomyosis and endometrial cancer. The inter- and intraobserver variability in the classification of EMJ visualisation using three-dimensional ultrasound was assessed and a high level of agreement was found. Endometrial thickness and parity were found to be significantly associated with the quality of EMJ visualisation. Seven recognised ultrasound features of adenomyosis, including an irregular endometrial-myometrial junction, were investigated fo

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22

Einarsdóttir, Kristjana. "Genetic determinants of postmenopausal breast and endometrial cancer /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-037-4/.

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23

Holland, C. M. "Genomic and post-genomic studies in endometrial cancer." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604158.

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Genomic abnormalities lead to aberrant cell growth and signalling, contributing to the development of malignancy. Growth and metastasis also require the development of tumour vasculature. The VEGFs and angiopoietins are growth factor families central to this process. This thesis examines their expression in endometrial cancer. Genomic and post-genomic studies are used to broaden the investigation of angiogenesis and include related pathways. Using <i>in situ</i> hybridisation VEGF-A mRNA was detected in epithelial cancer cells but not pre-malignant and benign endometrium while VEGF-B was local

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24

Davis, Warren. "Bioactivation of tamoxifen : its metabolites and metabolites to genotoxic species." Thesis, University of London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314343.

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25

Jurcevic, Sanja. "MicroRNA expression profiling in endometrial adenocarcinoma." Doctoral thesis, Örebro universitet, Institutionen för hälsovetenskap och medicin, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-41640.

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26

Chan, Carolyn. "Characterization of the extended kallikrein (KLK) gene family in the normal and malignant endometrium." Thesis, Queensland University of Technology, 2003.

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27

Martínez, García Elena. "Protein signatures in uterine aspirates to improve diagnosis of endometrial cancer "The CEMARK project"." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/458514.

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Alrededor del 30% de las pacientes con cáncer de endometrio (CE) son diagnosticadas en un estadio avanzado de la enfermedad, asociado con un drástico descenso de la supervivencia a los 5 años. El diagnóstico se realiza mediante el examen histopatológico de una biopsia endometrial, que se obtiene preferiblemente mediante una aspiración mínimamente invasiva del interior de la cavidad uterina (aspirado uterino). Desafortunadamente, el número limitado de células en estas biopsias está asociado a dos inconvenientes importantes: i) alrededor del 22% de pacientes no reciben un diagnóstico definitivo

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28

Koutoukidis, D. "Diet, nutrition and physical activity in endometrial cancer survivors." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1539075/.

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Endometrial cancer survivors comprise a high-risk group for obesity-related comorbidities. Healthy eating and physical activity can lead to better health and well-being, but this population may experience difficulties adopting healthy lifestyle practices. Personalised behaviour change programmes that are feasible, acceptable, and cost-effective are needed. Using various methodologies, this doctoral research aimed to develop and pilot a healthy eating and physical activity program. Through a systematic literature review and meta-analysis, study 1 demonstrated preliminary evidence that obesity i

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29

Chedumbarum, Pillay O. D. "The association between polycystic ovary syndrome and endometrial cancer." Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/19981/.

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HYPOTHESIS: Women suffering from polycystic ovary syndrome have an increased risk of developing endometrial carcinoma. AIM: To determine whether people with polycystic ovary syndrome have an increased risk of developing endometrial carcinoma. BACKGROUND: Endometrial cancer is one of the commonest cancers to occur in women in the Western World and unopposed oestrogen stimulation of the uterus is amongst one of the aetiologies postulated for this condition. It is generally assumed that women with polycystic ovary syndrome are more likely to develop endometrial hyperplasia and carcinoma for the r

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30

Kalogera, Eleftheria. "Quinacrine in endometrial cancer| Repurposing an old antimalarial drug." Thesis, College of Medicine - Mayo Clinic, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10111530.

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<p> <u>Background and Rationale:</u> Although the majority of patients with endometrial cancer (EC) are diagnosed early when disease is confined in the uterus and prognosis is excellent, there is a subset of patients with dismal prognosis. Carboplatin and paclitaxel is the standard chemotherapeutic regimen for EC. Given that response to chemotherapy impacts disease prognosis, especially in advanced, recurrent and metastatic disease, novel chemotherapeutic agents with improved safety profile are necessary to improve response rates and outcomes in these patients. Quinacrine (QC) is an inexpensiv

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31

Crosland, Rachel. "Studies of the PTEN tumour suppressor in endometrial cancer." Thesis, Sheffield Hallam University, 2004. http://shura.shu.ac.uk/19515/.

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Somatic mutations in the PTEN gene (Phosphatase and Tensin Homologue Deleted on Chromosome Ten) have been found in many types of cancer, but most frequently in cancer of the endometrium. The PTEN gene encodes a D3 lipid phosphatase of the second messenger phosphatidylinositol 3,4,5-trisphosphate (PIP3), which activates protein kinase B/Akt. Constitutive activation of Akt has been found in cells that lack functional PTEN, thus by dephosphorylating PIP3, this enzyme modulates several cellular functions e.g. proliferation, differentiation and migration. The PTEN protein comprises a 403 amino acid

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32

Ziou, Arisa. "Gene expression of MYPT1 and ROCK1 in endometrial cancer." Thesis, Högskolan i Skövde, Institutionen för hälsovetenskaper, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-19249.

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Endometrial adenocarcinoma is a cancer that develops from the endometrium, from cells thatform the glands in the endometrium. Animal models such as the BDII rat have thecharacteristic property that they are prone to cancers, characterized by rapid tumor growth,that resemble human cancers. Such rat models are therefore used to study gene expression andsignal pathways in cancer. Cancer cells have the ability to invade surrounding tissues throughlymphatic and/or vascular circulation to produce secondary tumors at new sites. TheRho/ROCK pathway orchestrates cell motility thereby contributing in si

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33

Haughian, James M. "Defining protein kinase C function in endometrial cancer cells /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2008. http://proquest.umi.com/pqdweb?did=1545964851&sid=2&Fmt=6&clientId=18952&RQT=309&VName=PQD.

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Thesis (Ph.D. in Reproductive Sciences) -- University of Colorado Denver, 2008.<br>Typescript. Includes bibliographical references (leaves 150-183). Free to UCD Anschutz Medical Campus. Online version available via ProQuest Digital Dissertations;

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Hill, Deirdre A. "Hormone use patterns, intrauterine device use, and endometrial cancer /." Thesis, Connect to this title online; UW restricted, 1997. http://hdl.handle.net/1773/10899.

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35

Kamal, A. M. "Endometrial cancer : involvement of androgens and metastasis inducing proteins." Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/3004396/.

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The alarming escalation of endometrial cancer incidence with associated parallel rise in mortality has increased the urge to find reliable prognostic markers in order to improve risk stratification of patients and therefore promote more individualised treatment strategies. The principal goal of this thesis was to examine the prognostic role of steroid hormone receptors, particularly AR, and metastasis inducing proteins S100A4, S100P and AGR2 in endometrial cancer and to investigate the hormonal regulation of these proteins. A comprehensive expression profile for each of these target proteins w

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Sivalingam, Vanitha. "The role of metformin in obesity-driven endometrial cancer." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-metformin-in-obesitydriven-endometrial-cancer(5a4418b9-5dab-4e6a-be05-9180996073c1).html.

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Endometrial cancer (EC) is the most common gynaecological cancer affecting women in developed countries. Improving outcomes for women who are unfit for primary surgery or have advanced disease remains a challenge. Metformin use is associated with reduced cancer risk in several observational studies of patients with type 2 diabetes. Pre-clinical studies in EC show that metformin reduces cellular proliferation. The work described in this thesis tests the hypothesis that metformin reduces cellular proliferation in vitro and in vivo in type I EC through actions on the PI3K/AKT/mTOR pro-proliferati

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Wang, Yue, and 王悦. "Molecular analysis of mitochondrial DNA alterations in endometrial carcinomas." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B32059127.

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Doherty, Jennifer Anne. "Genetic influences on estrogen biosynthesis, catabolism, and response in relation to the incidence of endometrial cancer /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/10869.

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Juraskova, Ilona. "Psycho-sexual adjustment following treatment for early stage cervical and endometrial cancer." Phd thesis, School of Psychology, 2003. http://hdl.handle.net/2123/3928.

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40

Obón, Santacana Mireia. "Dietary intake and biomarkers of acrylamide exposure and risk of endometrial and ovarian cancer: A molecular epidemiologic study in the European Prospective Investigation into Cancer and Nutrition." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/401757.

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Acrylamide is an organic chemical that has several important uses in industry, such as a flocculant in public water supplies, and in biomedical research. In 1994, acrylamide was classified by the International Agency for Research on Cancer as ‘probably carcinogenic’ to humans. In 2002, acrylamide was discovered in some starchy foods that are cooked at high temperature (e.g., potato crisps and chips). Acrylamide also is a common component of cigarette smoke. From 2006-2010, epidemiologic studies began to examine and report on the possible association between dietary acrylamide intake and risk o

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41

Santacana, Espasa Maria. "Utilitat de la Immunohistoquímica i els Tissue Micro Arrays en el coneixement de les alteracions moleculars del càncer d'endometri." Doctoral thesis, Universitat de Lleida, 2015. http://hdl.handle.net/10803/307214.

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Generalment el Càncer d’Endometri (EC) s’associa a bon pronòstic, no obstant el 20% dels EC associats a bon pronòstic recidiven. El propòsit d’aquesta tesi ha estat l’estudi de les principals diferències en l’expressió de gens implicats en el desenvolupament i progressió del CE i que estan relacionats amb la hipòxia, l’apoptosi i l’adaptació a la radioteràpia mitjançant la Immunohistoquímica i els Arrays matricials de teixit en CE primaris i recidives post radioteràpia. Les recidives presenten valors més elevats de p53, HIF-1α, FLIP, Ki67, p50, c-REL, Rel B i β-catenina. La hipòxia activa ta

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42

Wallace, Alison E. "F-prostanoid receptor regulation of inflammation in endometrial adenocarcinoma." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4447.

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Endometrial adenocarcinoma is the most common gynaecological malignancy in Western countries, affecting mainly post-menopausal women with a frequency of 15-20 per 100 000 women per year. Over-expression of the cyclooxygenase (COX) enzymes and prostaglandin receptors has been demonstrated in endometrial adenocarcinoma as well as other gynaecological pathologies. Increased expression of the prostaglandin F2α (PGF2α) receptor (FP) has been previously demonstrated in endometrial adenocarcinoma. A role for the FP receptor in the promotion of endometrial adenocarcinoma has been shown, with evidence

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43

Velasco, Sánchez Ana. "Oncogenes y genes supresores de tumores en carcinoma de endometrio." Doctoral thesis, Universitat de Lleida, 2012. http://hdl.handle.net/10803/110545.

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El objetivo principal de este trabajo ha sido la identificación de alteraciones moleculares que participen de manera significativa en el desarrollo y la progresión del cáncer de endometrio, con el propósito de añadir mas claves para el descubrimiento de nuevas dianas de diagnosis y terapias individuales contra esta patología. El trabajo ha sido centrado en el estudio de modificaciones en el ADN de las células que forman el tejido tumoral en una serie de pacientes con carcinoma endometrial, en concreto, en el análisis mutacional de los genes PIK3CA y FGFR2 y el análisis de hipermetilación del p

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44

Fearon, Abbie Elizabeth. "Dissection of drug resistance mechanisms in FGFR2 mutant endometrial cancer." Thesis, Queen Mary, University of London, 2015. http://qmro.qmul.ac.uk/xmlui/handle/123456789/9027.

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Mutations in FGFR2 are common in a subset of endometrial carcinomas. Given the emergence of small molecule inhibitors specific to this receptor tyrosine kinase, FGFR2 is an attractive therapeutic target. However, compensatory and adaptation mechanisms limit the clinical utility of compounds that target nodes in the receptor tyrosine kinase network. Here, we analysed the impact of FGFR inhibition in endometrial cancer cells and observed the emergence of a resistant population in an FGFR2-mutant cell line. To understand the mechanisms underlying this adaptation response, we used a phosphoproteom

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Sahbai, Samine [Verfasser]. "Scintigraphic detection of sentinel nodes in endometrial cancer / Samine Sahbai." Tübingen : Universitätsbibliothek Tübingen, 2019. http://d-nb.info/1227963939/34.

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Denu, Stefanie. "Impact of Acceptance and Body Compassion in Endometrial Cancer Patients." Xavier University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=xavier1531398277520261.

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Hovey, Adriann Marie. "Characterization of miR-888 expression and regulation in endometrial cancer." Diss., University of Iowa, 2014. https://ir.uiowa.edu/etd/4649.

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Endometrial cancer is the fourth most common cancer in women and the most common gynecological malignancy. While patient outcome has improved for the majority of cancers, the outlook for endometrial cancer has steadily decreased. In order to address this problem, we must better understand the different mechanisms involved in endometrial cancer development and progression. To this end, we quantified expression of 667 miRNAs in four endometrioid adenocarcinoma and four serous adenocarcinoma using Taqman Low Density Arrays (TLDAs). miR-888 was one of the most highly overexpressed miRNAs in both e

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Geng, Xinyan. "Investigations into how best to target FGFR2 mutant endometrial cancer." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/123437/1/Xinyan%20Geng%20Thesis.pdf.

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Endometrial cancer (EC) is the fourth most common cancer in women in developed countries, such as North America, Europe and Australia. Patients with low-grade, early-stage disease usually have a favourable survival rate. However, patients that present at an advanced stage of disease have an average survival of only 12 months. Current treatments for these patients are radiation and chemotherapy, which offer limited clinical benefit. There is no efficient treatment for advanced EC. Improved therapeutic approaches are needed for the treatment of recurrent and metastatic endometrial cancer. Recent

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Chan, Kwan-yi Queeny, and 陳君怡. "Molecular study of pi-class glutathione-S-transferase in endometrial carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B29157717.

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Cubo, Abert Montserrat. "Estadificación prequirúrgica del carcinoma endometrial mediante ecografía en dos y tres dimensiones." Doctoral thesis, Universitat Autònoma de Barcelona, 2021. http://hdl.handle.net/10803/672056.

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Objectius: El nostre objectiu era comparar el rendiment diagnòstic de l’ecografia transvaginal (ETV) i la ressonància magnètica (RM) per predir la profunditat de la invasió miometrial (IMP) i la invasió estromal cervical (IEC) en pacients amb càncer d’endometri (CE). Mètodes: Estudi prospectiu i consecutiu que inclou totes les pacients amb CE diagnosticades entre l’octubre del 2013 i el juliol del 2018 a l’Hospital Vall d’Hebron de Barcelona. Es va realitzar una estadificació preoperatòria amb ETV i ressonància magnètica seguida d’una estadificació quirúrgica. La histologia final es va consid

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