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Journal articles on the topic 'Endometrial cance'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

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1

Arai, Y., and M. Nishida. "Differential diagnosis between normal endometrium and endometrial hyperplasia with immunostaining cytology using anti-LeY monoclonal antibody." International Journal of Gynecologic Cancer 13, no. 1 (2003): 42–46. http://dx.doi.org/10.1136/ijgc-00009577-200301000-00008.

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We have previously reported that both endometrial cancer and endometrial hyperplasia stain positively for the anti-LeY monoclonal antibody, whereas normal endometrium does not. Endometrial hyperplasia is a premalignant change associated with the eventual development of endometrial carcinoma. However, it can be difficult to differentiate hyperplasia from normal endometrium in cytology. This study illustrates the use of immunocytochemical cytology using anti-LeY monoclonal antibody to differentiate between endometrial hyperplasia and normal endometrium. Immunostaining using anti-LeY monoclonal a

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Liolis, Elias, Francesk Mulita, Angelos Koutras, Thomas Makatsoris, and Gregory Sivolapenko. "Exploring Bevacizumab's Role in Gynecological Cancers: An Up-to-Date Narrative Review Focusing on Ovarian Cancer." Materia Socio Medica 36, no. 4 (2024): 268. https://doi.org/10.5455/msm.2024.36.268-279.

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Background: The Gynecological cancers, including ovarian cancer, endometrial cancer, breast cancer, and cervical cancer, have increased in frequency lately and it is estimated that one million cases are diagnosed every year worldwide. Bevacizumab is considered one of the first anti-angiogenic therapies as it is a monoclonal antibody binding to factors essential for tumor angiogenesis. Objective: This paper aims to review the most important findings of the literature that highlight the role of bevacizumab in gynecological cancers with a special emphasis on ovarian cance. Methods: For this narra

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Joshi, Narendra, Kalpesh Patel, Bhawani Shankar Sharma, Neeraj Choudhary, and Balveer Jakhar. "Prospective study of role of transvaginal sonography in postmenopausal bleeding and its histopathological correlation: a prospective study from a tertiary care hospital of Rajasthan." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 14, no. 4 (2025): 1235–43. https://doi.org/10.18203/2320-1770.ijrcog20250868.

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Postmenopausal bleeding is vaginal bleeding that occurring after one years of menopause. When periods have stopped for more than one years in women who are generally over than 45 years old and it is common condition in postmenopausal women, it can be the presenting symptom of endometrial cancer. Aim of study is to assess endometrial thickness by vaginal sonography and correlate it with the cytological pattern evaluated by endometrial sampling and histopathological typing of the endometrium. Methods: This is a prospective observational study conducted in department of obstetrics and gynaecology

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CAPLAKOVA, VERONIKA, EVA BABUSIKOVA, EVA BLAHOVCOVA, TOMAS BALHAREK, MARIA ZELIESKOVA, and JOZEF HATOK. "DNA Methylation Machinery in the Endometrium and Endometrial Cancer." Anticancer Research 36, no. 9 (2016): 4407–20. http://dx.doi.org/10.21873/anticanres.10984.

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Abdullah Abdulrazak, Aiad. "Computerized histomorphometry in the diagnosis of pre-malignant endometrial lesions." Tikrit Journal of Pharmaceutical Sciences 8, no. 1 (2023): 128–38. http://dx.doi.org/10.25130/tjphs.2012.8.1.17.128.138.

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Accurate diagnosis of precursors to endometrial cancer is a major challenge to pathologists. D-score is well reproducible and predictive of prognosis than the WHO schema, however it is not widely available, this study is an attempt to design a simple workstation for estimation of D-score. Fifteen samples of endometrium with low grade hyperplasia, fifteen proliferative and eight secretory phase endometria were analyzed by light microscopy and stereology. Severeal architectural and karyometric parameters were evaluated and the D-score was calculated. The volume density of stroma (VPS) was signif

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Mazzola, R., F. Ricchetti, S. Fersino, et al. "PD-0438: Adjuvant volumetric modulated arc therapy with vaginal cuff simultaneous integrated boost in endometrial cance." Radiotherapy and Oncology 115 (April 2015): S214. http://dx.doi.org/10.1016/s0167-8140(15)40434-7.

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Silveira, Débora Filardi, Carlos Alberto Rodrigues Junior, Fellipe Camargo Ferreira Dias, Camila Filardi Silveira, and Caroline Filardi Silveira. "Avaliação ultrassonográfica no espessamento endometrial: revisão de literatura." Revista de Patologia do Tocantins 4, no. 4 (2017): 60. http://dx.doi.org/10.20873/uft.2446-6492.2017v4n4p60.

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Introdução: A avaliação ecográfica do endométrio permite a análise minuciosa da mucosa uterina na prática clínica ginecológica, com o intuito de auxiliar no manejo das patologias endometriais. Neste artigo, fazemos uma revisão narrativa para avaliar o real papel da ecografia pélvica na visualização das doenças endometriais. As alterações uterinas, como pólipos, miomas, sinéquias uterinas, hiperplasia e câncer endometrial são morbidades frequentes na população feminina, tanto nas pacientes em idade reprodutiva como nas que estão na pós-menopausa. Os métodos de avaliação endometrial têm obtido d

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Mokhtar, N. M., F. SA Saghir, A. Mohd Dali, I. Mohamed Rose, and A. A. Jamal. "409. Differentially expressed genes in endometroid endometrial carcinoma using microarray: a preliminary report." Reproduction, Fertility and Development 20, no. 9 (2008): 89. http://dx.doi.org/10.1071/srb08abs409.

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Background: Endometrial cancer is the commonest cancer among women in the western countries. It ranks the fourth in gynaecological cancers incidence in Malaysia. Endometriod carcinoma is the commonest subtype of endometrial cancer. The aetiology of this disease is still not fully understood. Previous theories have suggested the disease is caused by the activation of oncogenes and inactivation of the tumour suppressor genes. The aim of this study is to identify expressing genes involved in the endometrial carcinoma compared with the normal endometrium. Materials and Methods: All endometrial tis

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Mandic, Aljosa, and Tamara Vujkov. "Endometrial cancer: Diagnostic methods in postmenopausal vaginal bleeding." Archive of Oncology 11, no. 2 (2003): 97–101. http://dx.doi.org/10.2298/aoo0302097m.

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Postmenopausal vaginal bleeding (PMB) is the leading symptom of endometrial cancer. More than 70% of patients with endometrial cancer are postmenopausal. Despite PMB as a leading symptom in diagnosis of endometrial cancer, PMB could be caused by some benign processes in endometrium such as hyperplasia and focal endometrial disease, such as a polyp. The golden standard for histological evaluation of the endometrium is curettage. Transvaginal ultrasound (TVS) and measurement of endometrium thickness is also one of the favored methods in the last decade. Sonographic imaging of the endometrium can

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10

Easo, Anu Sarah, Rajeev Anand, and Mini Issac. "Evaluation of apparent diffusion coefficient in endometrial carcinoma compared to normal endometrium: a retrospective study." International Journal of Research in Medical Sciences 9, no. 7 (2021): 2043. http://dx.doi.org/10.18203/2320-6012.ijrms20212356.

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Background: To determine whether diffusion-weighted imaging (DWI) with measurement of apparent diffusion coefficient (ADC) will help in differentiating endometrial cancer from normal endometrium and to determine whether the grades of endometrial cancer will show significant difference in ADC values.Methods: This is a retrospective study done in MOSC medical college hospital Kolencherry. on patients on whom preoperative MRI was done before hysterectomy. Cases from July 2017 to March 2021 were included. Study cases included 40 females with pathologically confirmed endometrial cancer and 30 femal

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Capaci, Valeria, Giorgio Arrigoni, Lorenzo Monasta, et al. "Phospho-DIGE Identified Phosphoproteins Involved in Pathways Related to Tumour Growth in Endometrial Cancer." International Journal of Molecular Sciences 24, no. 15 (2023): 11987. http://dx.doi.org/10.3390/ijms241511987.

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Endometrial cancer (EC) is the most common gynecologic malignancy of the endometrium. This study focuses on EC and normal endometrium phosphoproteome to identify differentially phosphorylated proteins involved in tumorigenic signalling pathways which induce cancer growth. We obtained tissue samples from 8 types I EC at tumour stage 1 and 8 normal endometria. We analyzed the phosphoproteome by two-dimensional differential gel electrophoresis (2D-DIGE), combined with immobilized metal affinity chromatography (IMAC) and mass spectrometry for protein and phosphopeptide identification. Quantities o

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Dewi Anggraeni, Tricia, Raymond Surya, and Andrew Pratama Kurniawan. "Obesity and Endometrial Cancer: Mechanism and How to Deal with?" Cermin Dunia Kedokteran 48, no. 6 (2021): 343. http://dx.doi.org/10.55175/cdk.v48i6.1437.

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<p>Obesity is strongly associated with development of endometrial cancer more than any other cancer type. The relationship between obesity and endometrial cancer risk is combination of inflammation, insulin resistance, and increased bioavailability of estrogen. Obesity can increase risk to develop endometrial cancer as exogenous estrogen has impact for tumorigenesis. The best method to reduce the risk of endometrial cancer in obese women is through progesterone medication and lifestyle intervention.</p><p>Obesitas erat kaitannya dengan terjadinya kanker endometrium lebih dari

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Mladenovic-Segedi, Ljiljana, Milos Pantelic, and Dragan Stajic. "Endometrial carcinoma in asymptomatic postmenopausal women with a thickened endometrium." Medical review 75, no. 11-12 (2022): 333–37. http://dx.doi.org/10.2298/mpns2212333m.

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Introduction. The most common clinical manifestation of endometrial cancer is postmenopausal bleeding, as well as irregular uterine bleeding. Far less often, endometrial cancer may also be present in postmenopausal women without bleeding. The aim of our study was to examine the incidence of endometrial cancer in asymptomatic postmenopausal women with a thickened endometrium. Material and Methods. The research included 251 asymptomatic postmenopausal women with endometrial thickness over 4 mm established by ultrasound. Exploratory curettage was performed in all the patients, followed by histopa

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Boyarskikh, Ulyana, Andrey Kechin, Evgeniy Khrapov, et al. "Detecting Microsatellite Instability in Endometrial, Colon, and Stomach Cancers Using Targeted NGS." Cancers 15, no. 20 (2023): 5065. http://dx.doi.org/10.3390/cancers15205065.

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Purpose: To develop a method for testing the MSI based on targeted NGS. Methods: Based on the results of previous studies, 81 microsatellite loci with high variability in MSI-H tumors were selected, and a method for calculating the MSI score was developed. Using the MSI score, we defined the MSI status in endometral (162), colon (153), and stomach (190) cancers. Accuracy of the MSI scores was evaluated by comparison with MMR immunohistochemistry for 137 endometrium (63 dMMR and 74 pMMR), 76 colon (29 dMMR and 47 pMMR), and 81 stomach (8 dMMR and 73 pMMR) cancers. Results: Classification of MSS

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Coelho, Jyotsna Mirabel, Nagarathna G., and Dinesh Shet. "Study of tamoxifen associated endometrial changes in women with breast cancer: a prospective study." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 12, no. 12 (2023): 3542–47. http://dx.doi.org/10.18203/2320-1770.ijrcog20233631.

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Background: Studies have estimated that women with breast cancer on tamoxifen therapy have a greater risk of developing endometrial cancer. We undertook this study to correlate the ultrasonographic findings, hysteroscopy findings and endometrial pathology in breast cancer patients on tamoxifen. Methods: This was a prospective study conducted over a period of two years. Patients of histologically proven breast cancer on tamoxifen treatment for more than a year were taken into the study. Transvaginal ultrasonography and hysteroscopic biopsy (if endometrial thickness on TVS was 8mm or more) was p

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Degasper, Christine, Andrea Brunner, Natalie Sampson, et al. "NADPH oxidase 4 expression in the normal endometrium and in endometrial cancer." Tumor Biology 41, no. 2 (2019): 101042831983000. http://dx.doi.org/10.1177/1010428319830002.

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The aim of this study was to explore the role of NOX4 in the biology of the normal endometrium and endometrial cancer. NOX4 plays a key role in other adenocarcinomas and has been implicated in the pathogenesis of diabetes and obesity, which are important risk factors for endometrial cancer. NOX4 expression was assessed in 239 endometrial cancer and 25 normal endometrium samples by quantitative real-time polymerase chain reaction, in situ hybridization, and immunohistochemistry. DNA methylation of the NOX4 promoter was determined by means of MethyLight PCR. Data were correlated with clinicopath

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Jabłoński, Krzysztof, Łukasz Kurek, Maciej Żukowski, et al. "Elastography of Endometrium in Women Taking Tamoxifen: A New Approach to an Old Diagnostic Problem." Journal of Clinical Medicine 9, no. 12 (2020): 3870. http://dx.doi.org/10.3390/jcm9123870.

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Tamoxifen is a commonly used selective estrogen receptor modulator applied in the treatment for breast cancer. However, in the endometrium, Tamoxifen stimulates tissue growth, cellular transformation, the migration of the cells, and metastatic potential in endometrial cancer. Considering that uterine cancer is the most common neoplasm of the reproductive tract and the third most common neoplastic disease in women, the aim of this study was to investigate if applying elastography in examining the endometrium was beneficial for uterine cancer screening protocols in women on selective estrogen re

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Bohiltea, Roxana Elena, Corina Grigoriu, Bianca-Margareta Mihai, et al. "Ten ultrasound endometrial issues." Romanian Medical Journal 68, S6 (2021): 37–48. http://dx.doi.org/10.37897/rmj.2021.s6.7.

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Abnormal uterine bleeding is probably the most frequent gynecological issue that leads women to a consult with a subsequent ultrasound. Transvaginal ultrasonographic evaluation represents the most sensitive method of endometrial evaluation, being more adequate than the transabdominal approach, especially when differentiating the benign lesions from the malignant ones. Transvaginal ultrasound is extremely useful in measurement, morphology and vascularization examination of the uterine cavity, especially the endometrium. We present 10 endometrial issues in which transvaginal ultrasound has prove

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Kulinczak, Mariusz, Maria Sromek, Grzegorz Panek, et al. "Endometrial Cancer-Adjacent Tissues Express Higher Levels of Cancer-Promoting Genes than the Matched Tumors." Genes 13, no. 9 (2022): 1611. http://dx.doi.org/10.3390/genes13091611.

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Molecular alterations in tumor-adjacent tissues have recently been recognized in some types of cancer. This phenomenon has not been studied in endometrial cancer. We aimed to analyze the expression of genes associated with cancer progression and metabolism in primary endometrial cancer samples and the matched tumor-adjacent tissues and in the samples of endometria from cancer-free patients with uterine leiomyomas. Paired samples of tumor-adjacent tissues and primary tumors from 49 patients with endometrial cancer (EC), samples of endometrium from 25 patients with leiomyomas of the uterus, and

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Pańczyszyn, Anna, Ewa Boniewska-Bernacka, Karolina Włodarczyk, Iwona Wertel, and Anna Goc. "Telomeres and telomerase in endometrial cancer and hyperplasia." Archives of Medical Science 20, no. 2 (2024): 682–85. http://dx.doi.org/10.5114/aoms/186189.

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IntroductionThe study aimed to measure telomeres length (TL) and telomerase expression in normal endometrium and endometrial hyperplasia and cancer.Material and methodsTotal RNA and DNA were isolated from endometrium samples of 117 patients. The RT-PCR method was used to determine telomerase expression and relative telomere length.ResultsThe control group had the longest telomeres in comparison to the hyperplasia and endometrial cancer groups. Only in the endometrial cancer group was telomerase expressed and positively correlated with telomere length.ConclusionsTelomere extension in endometria

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Kathuria, Priyanka. "#331 : Bilateral Endometriomas Masquerading Synchronous Endometrial and Ovarian Cancer (SEOC) in an Infertile Female." Fertility & Reproduction 05, no. 04 (2023): 512–13. http://dx.doi.org/10.1142/s2661318223742753.

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Background and Aims: Endometriomas are diagnosed in clinical practice by imaging (mostly ultrasound) in females presenting with infertility. CA-125 level is an adjuvant investigation which may be indicative of endometriosis. A few research questions that are yet to be answered. Is ultrasound a sufficient modality to diagnose endometrioma? Is there any cut off as far as the measurement of endometrioma is concerned to step up the imaging modality to MRI? Synchronous endometrial and ovarian cancer (SEOC) is a rare phenomenon with an incidence of 1.4 - 3.8%. Mostly in SEOC, the ovarian endometroid

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Abe, Naoya, Jun Watanabe, Shinpei Tsunoda, Hiroyuki Kuramoto, and Isao Okayasu. "Significance of Nuclear p-Akt in Endometrial Carcinogenesis: Rapid Translocation of p-Akt Into the Nucleus by Estrogen, Possibly Resulting in Inhibition of Apoptosis." International Journal of Gynecologic Cancer 21, no. 2 (2011): 194–202. http://dx.doi.org/10.1097/igc.0b013e318207964c.

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Introduction:Endometrial endometrioid adenocarcinoma (endometrial cancer) develops through endometrial hyperplasia caused by estrogenic hyperstimulation. Estrogen is known to activate growth factor signaling pathways, resulting in cellular proliferation, but precisely how has not been clarified. The aim of this study was to investigate the significance of estrogen and downstream factors such as the MAPK (MEK, ERK) and Akt pathways in endometrial carcinogenesis.Methods:The expression of p-MEK, p-ERK, and p-Akt was analyzed immunohistochemically in normal, hyperplastic, and neoplastic endometria

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KÖSE, Mesut, Ayhan VURMAZ, and Yasemin ÇELİK. "BENİGN, PRE-MALİGN VE MALİGN ENDOMETRİYAL LEZYONLARDA PROLİDAZ AKTİVİTESİ VE OKSİDATİF STRES." Kocatepe Tıp Dergisi 24, no. 2 (2023): 195–200. http://dx.doi.org/10.18229/kocatepetip.1105749.

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OBJECTIVE: The present study aims to investigate the prolidase activity, total oxidant status (TOS) and total anti-oxidant status (TAS) in women who have been diagnosed with benign, pre-malignant and malignant endometrial pathologies. MATERIAL AND METHODS: Ninety women who underwent endometrial biopsy due to abnormal uterine bleeding were divided into three groups according to their histopathological findings: Benign endometrial pathology (n=65), endometrial hyperplasia (n=12) and endometrial cancer (n=13). These groups were compared with respect to oxidative stress markers and prolidase activ

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Delforce, Sarah J., Eugenie R. Lumbers, Celine Corbisier de Meaultsart, et al. "Expression of renin–angiotensin system (RAS) components in endometrial cancer." Endocrine Connections 6, no. 1 (2017): 9–19. http://dx.doi.org/10.1530/ec-16-0082.

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A dysfunctional endometrial renin–angiotensin system (RAS) could aid the growth and spread of endometrial cancer. To determine if the RAS is altered in endometrial cancer, we measured RAS gene expression and protein levels in 30 human formalin-fixed, paraffin-embedded (FFPE) endometrioid carcinomas and their adjacent endometrium. All components of the RAS were expressed in most tumours and in adjacent endometrium; mRNA levels of (pro)renin receptor (ATP6AP2), angiotensin II type 1 receptor (AGTR1), angiotensin-converting enzyme (ACE1) and angiotensin-converting enzyme 2 (ACE2) mRNA levels were

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Ellinidi, Vera N., Elizaveta A. Smaglenko, Viktoria A. Pechenikova, Igor A. Samusenko, and Maxim V. Bunyakov. "Human leukocyte antigen, isotype DR (HLA-DR) expression in the normal endometrium and in endometrial pathology." Journal of obstetrics and women's diseases 73, no. 5 (2024): 96–104. https://doi.org/10.17816/jowd632930.

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BACKGROUND: Human leukocyte antigen, isotype DR (HLA-DR) expression is associated with inflammatory and autoimmune diseases. It is also found on the surface of tumor cells. The role of HLA-DR in endometrial pathology has not been sufficiently studied. AIM: The aim of this study was to determine HLA-DR expression features in the endometrium under normal and pathological conditions. MATERIALS AND METHODS: We performed immunohistochemical examination of endometrial biopsy specimens, namely, 18 cases of endometrioid carcinomas, 139 cases of chronic endometritis, and 37 cases of endometrial polyps.

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Rusda, Muhammad, Andri Sipahutar, and Andrina Yunita Murni Rambe. "Application of International Endometrial Tumor Analysis in Abnormal Uterine Bleeding: A Case Report." Open Access Macedonian Journal of Medical Sciences 10, T7 (2022): 7–11. http://dx.doi.org/10.3889/oamjms.2022.9236.

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BACKGROUND: Abnormal uterine bleeding (AUB) is one of the clinical symptoms found in malignant conditions where the incidence of newly diagnosed cancers reached 100,000 cases in Europe in 2012 with an incidence of around 14.7/100,000 women. The International Endometrial Tumor Analysis (IETA) group, formed in Chicago in 2008, published a consensus stating how to examine and measure the endometrium. CASE REPORT: Mrs. M, 49 years old, came to Gynecology Clinic of USU Hospital on February 22, 2021, at 13.00 WIB with the complaints of prolonged menstruation for 2 months with a volume of >10 time

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Vaccaro, Emanuela, Luigi Navas, Martina Ercolano, et al. "Immunohistochemical Investigation of Cyclooxygenase-2 Expression in Rabbit Uterine Adenocarcinoma and the Potential Use of COX-2 Inhibitors in Cancer Therapy." Animals 14, no. 22 (2024): 3169. http://dx.doi.org/10.3390/ani14223169.

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Cyclooxygenase-2 (COX-2) is overexpressed in many human and animal cancers. Selective COX-2 inhibitors have shown antitumoral effects in tumors with a high expression of COX-2. This study evaluates (1) the expression of COX-2 in rabbit uterine adenocarcinomas, (2) the correlation between immunophenotypic expression and histopathological changes, and (3) the post-surgery response to therapy with COX-2 inhibitors. Forty rabbit uteri were divided into three groups: neoplastic, hyperplastic, and normal endometrium. A histological and immunohistochemical score was applied to investigate the tumor’s

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Helmanda, Shylvia, and Yusrawati Yusrawati. "Factors Related to Type of Endometrial Cancer in RSUP Dr. M. Djamil Padang." Indonesian Journal of Obstetrics & Gynecology Science 2, no. 2 (2019): 157. http://dx.doi.org/10.24198/obgynia.v2i2.122.

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Objective: This study aims to determine the relationship of risk factors with type of endometrial cancer.Method: This study used a cross sectional design in patients with endometrial cancer. Sampling uses total sampling technique, with a total sample of fifty six people. Data were obtained from the anatomical pathology section and medical records of Dr. RSUP M. Djamil Padang from 2016 until 2018. Analysis of data using Chi-Square test and logistic regressionResult: In this study, type I endometrial cancer is 75% cases while type II is 25% cases. Age, parity, diabetes mellitus, hypertension, ge

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Serteva, D., E. Poryazova, and Ts Velikova. "Endometriosis Locations and Coexistence with other Uterine Conditions in a Bulgarian Sample of Patients." American International Journal of Multidisciplinary Scientific Research 5, no. 2 (2019): 5–9. http://dx.doi.org/10.46281/aijmsr.v5i2.255.

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Endometriosis is a non-tumor, estrogen-dependent, chronic gynecological disease, which is characterized by the presence of endometrial glands and stroma outside the endometrium of the uterus. Endometriosis affects between 10% and 15% of women in reproductive age. It is often associated with chronic pelvic pain and reproductive difficulties. Endometriosis can be classified as ovarian, extra-ovarian or mixed. Adenomyosis is considered, by some authors, as a separate variant of endometriosis. It is diagnosed as the presence of ectopic benign endometrial glands and stroma in the myometrium, where

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Liu, Ming-Ming, Yu-Ting Liang, and Er-Hu Jin. "Endometrial carcinoma with cervical stromal invasion: Three case reports." World Journal of Clinical Cases 12, no. 24 (2024): 5583–88. http://dx.doi.org/10.12998/wjcc.v12.i24.5583.

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BACKGROUND Endometrial cancer is a kind of well-known tumors of female genitourinary system. Cervical stromal invasion is an adverse factor for poor prognosis of endometrial cancer. There is still controversy regarding the use of magnetic resonance imaging (MRI) in the diagnosis of cervical stromal invasion of endometrial cancer. The diagnosis of cervical stromal invasion varies significantly between different observers and institutions. We present a limited case series of the particular pattern of endometrial cancer, which infiltrates the cervical stroma and is often overlooked. CASE SUMMARY

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Liu, Xuerun, Jianliu Wang, and Jingyi Zhou. "The role of oestrogen and oestrogen-calcium axis in endometrial carcinoma." Gynecology and Obstetrics Clinical Medicine 4, no. 1 (2024): e000012. http://dx.doi.org/10.1136/gocm-2024-000012.

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Unopposed oestrogen is recognised as an inducer of endometrial cancer. Over the past 50 years, the effects of oestrogen on the endometrium and endometrial cancer have been a hot topic in the field of gynaecological oncology. In recent years, a series of studies by our team revealed that the non-genomic transcriptional effects of oestrogen can influence the progression of endometrial carcinoma by regulating calcium ions, suggesting that inhibiting calcium ion channel proteins could serve as an adjuvant therapy for endometrial cancer. In this review, we retrospectively summarise the sources of o

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Atkins, Sage, Angela Nolin, Shakthi Unnithan, et al. "Analysis of Timely Follow-Up in the Evaluation of Postmenopausal Bleeding." O&G Open 2, no. 1 (2025): e054. https://doi.org/10.1097/og9.0000000000000054.

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OBJECTIVE: To characterize guideline-adherent follow-up in patients evaluated with transvaginal ultrasonography (TVUS) for postmenopausal bleeding. METHODS: We conducted a retrospective study of patients with an intact uterus and postmenopausal bleeding who presented to a single academic institution and underwent TVUS between January 2013 and December 2022. Primary outcome measures were prompt follow-up, defined as receipt of endometrial sampling within 3 months of a finding of thickened or inadequately visualized endometrium, diagnosis of endometrial cancer, cancer stage at diagnosis, and rat

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Rawat, Rajani, Soniya Vishwakarma, Shikha Seth, Vaibhav Kanti, and Pragati Mishra. "Clear Cell Carcinoma of Endometrium: A Clinical Review." Journal of SAFOMS 2, no. 1 (2014): 15–19. http://dx.doi.org/10.5005/jp-journals-10032-1026.

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ABSTRACT Clear cell carcinoma of endometrium is a rare (1-6%) but aggressive malignancy with high propensity of early extra-uterine spread. The usual presentation is postmenopausal bleeding and discharge as with other endometrial cancers but it does not have preceding hyperplastic stage, instead it develops from thin atrophic endometrium, therefore impossible to identify by the screening measures like Pap smear and transvaginal sonography. First step for early diagnosis of such unfavorable endometrial cancer should be endometrial biopsy. Histopathological diagnosis is mandatory to confirm the

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Lugo, Carlos, and Nazira Monsalve. "Evaluación endometrial vía histeroscopia en pacientes con cáncer de mama – receptores hormonales positivos, tratadas con hormonoterapia." Revista de Obstetricia y Ginecología de Venezuela 80, no. 04 (2020): 312–21. http://dx.doi.org/10.51288/00800408.

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Objective: To know via hysteroscopy the endometrial pathology associated with the use of hormone therapy in patients with breast cancer. Methods: Research design: non-experimental, longitudinal, trend; based on patients who come randomly, from January to July 2014, to the consultation of Los Andes University Hospital. Results: The mean age of the patients was 55.3 years, mean time of menopause 8.03 years; 8 (26.6%) patients had associated chronic arterial hypertension and diabetes mellitus II, and 10% of the patients had arterial hypertension. The most common endometrial alterations were: 46.7

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KARAKUŞ, SAVAŞ, and TUNCAY Songul VARIS. "ENDOMETRIAL PATHOLOGIES IN MENSTRUAL IRREGULARITIES: A PRE- AND POST-COVID-19 COMPARATIVE STUDY." ID HEALTH SCIENCE 2, no. 2 (2024): 54–57. https://doi.org/10.5281/zenodo.12664819.

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To compare endometrial pathologies in patients with menstrual irregularity before and after the COVID-19 pandemic. This cross-sectional study examined 140 patients before COVID-19 and 150 patients after COVID-19 who presented with   menstrual irregularity. Endometrial thickness values, hysteroscopy findings, and pathology results were recorded via   transvaginal ultrasonography (USG) between days 3-6 of menstruation. Patients receiving hormone replacement therapy (HRT), having a positive COVID-19 test, systemic disease, using an intrauterine device, having fluid accumulatio

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Love, C. D. B., B. B. Muir, J. B. Scrimgeour, R. C. F. Leonard, P. Dillon, and J. M. Dixon. "Investigation of Endometrial Abnormalities in Asymptomatic Women Treated With Tamoxifen and an Evaluation of the Role of Endometrial Screening." Journal of Clinical Oncology 17, no. 7 (1999): 2050. http://dx.doi.org/10.1200/jco.1999.17.7.2050.

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PURPOSE: Tamoxifen is the most commonly prescribed adjuvant therapy for women with breast cancer. It has agonist activity on the endometrium and is associated with an increased risk of endometrial cancer. The aim of this study was to evaluate whether screening with transvaginal ultrasound (TV USS) with or without hysteroscopy is worthwhile. PATIENTS AND METHODS: A total of 487 women with breast cancer, 357 treated with tamoxifen and 130 controls, were screened with TV USS, and endometrial thickness was measured. Women with thickened endometrium underwent outpatient hysteroscopy. RESULTS: Lengt

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Saccardi, Carlo, Salvatore Gizzo, Tito Silvio Patrelli, et al. "Endometrial surveillance in tamoxifen users: role, timing and accuracy of hysteroscopic investigation: observational longitudinal cohort study." Endocrine-Related Cancer 20, no. 4 (2013): 455–62. http://dx.doi.org/10.1530/erc-13-0020.

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To determine the role, timing and indications for endometrial hysteroscopic investigation in relation to the clinical, ultrasound and histological features of the endometrium during tamoxifen (TAM) use. We performed an observational longitudinal cohort study (years 2007–2012) that investigated the endometria of 151 TAM users with hysteroscopy and histology. For all patients, gynaecological history, years of adjuvant treatment, ultrasound endometrial thickness measurement and indications for hysteroscopy were recorded. Hysteroscopic findings showed that 100% of patients referred for simple foll

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Habler, L., R. Halperin, S. Zehavi, E. Hadas, I. Bukovsky, and D. Schneider. "Simultaneous carcinoma of the endometrium and ovary vs. endometrial carcinoma with ovarian metastases: A clinical and immunohistochemical determination." International Journal of Gynecologic Cancer 13, no. 1 (2003): 32–37. http://dx.doi.org/10.1136/ijgc-00009577-200301000-00006.

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The aim of this study was to perform a clinical and immunohistochemical comparison between simultaneous independent tumors involving endometrium and ovary and metastatic endometrial tumors, and to try to find clinical and /or immunohistochemical parameters differentiating between these two entities. Sixteen cases of simultaneous independent primaries of endometrium and ovary, presenting the same histologic type, were compared with 12 cases of primary endometrial cancer, demonstrating ovarian metastases. The comparison related to patients' characteristics and immunohistochemical expression of e

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Li, Xiao, Yiping Gao, Mingzi Tan, et al. "Expression of HE4 in Endometrial Cancer and Its Clinical Significance." BioMed Research International 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/437468.

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The main aims of this study were to determine the expression of human epididymis protein 4 (HE4) in endometrial cancer and to explore the relationships between HE4 expression, clinicopathological parameters, and prognosis. Immunohistochemistry was used to detect HE4 expression in 102 cases of endometrial cancer, 30 cases of endometrial atypical hyperplasia, and 20 cases of normal endometrium. The positive expression rate of HE4 in endometrial carcinoma was 84.62%, significantly higher than 66.67% in atypical hyperplasia (P<0.05) and 15.00% in normal endometrium (P<0.0.01). With the excep

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Vukićević, D., Ž. Perišić, V. Plešinac-Karapandžić, et al. "ENDOMETRIAL CARCINOMA." Praxis medica 36, no. 2 (2008): 103–10. http://dx.doi.org/10.70949/pramed200802257v.

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&lt;p&gt;Endometrial carcinoma is still one of the most common malignant tumor of the female genital system in the most industrialized countries. Endometrial cancer is due to 3,9% of all female malignant tumors. The occurence of endometrial cancer varies with age. In 75% of all cases endometral carcinoma tipically occurs in postmenopausal women, with the highest incidence between 50 and 59 year. The high frequence of endometrial carcinoma in younger age is also found in women with ovarian estrogen-secreting tumors. About 10% of all endometrial carcinomas also in association with a gene

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Adomaitienė, Nadišauskienė, Nickkho-Amiry, et al. "Proliferation in Postmenopausal Endometrial Polyps—A Potential for Malignant Transformation." Medicina 55, no. 9 (2019): 543. http://dx.doi.org/10.3390/medicina55090543.

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Background and objectives: Endometrial polyps in asymptomatic postmenopausal women are often incidentally found, yet only 1.51% of them are malignant. Their potential for malignant transformation has not been adequately addressed. The aim of this study was to investigate the proliferation within endometrial polyps as one of the indicators of their malignization potential in asymptomatic postmenopausal women. Materials and Methods: Immunohistochemical studies of Ki-67 were performed. Cases included 52 benign postmenopausal polyps, 19 endometrioid carcinoma with coexisting benign polyps, 12 poly

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Lépine, Johanie, Etienne Audet-Walsh, Jean Grégoire, et al. "Circulating Estrogens in Endometrial Cancer Cases and Their Relationship with Tissular Expression of Key Estrogen Biosynthesis and Metabolic Pathways." Journal of Clinical Endocrinology & Metabolism 95, no. 6 (2010): 2689–98. http://dx.doi.org/10.1210/jc.2010-2648.

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Abstract Background: Endometrial cancer is the most common gynecological malignancy. Estrogen exposure is strongly associated with endometrial cancer. Whereas this cancer occurs predominantly in postmenopausal women lacking estrogen production by ovaries, the conversion of adrenal androgen-estrogen precursors to estradiol (E2), estrone (E1), and its sulfate (E1-S) has been well documented in peripheral tissues. Experimental Design: We initially explored whether circulating levels of estrogens, measured by validated mass spectrometry assays, differ in women with endometrial cancer (n = 126) com

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Putra, Very Great Eka, and Teuku Mirza Iskandar. "Endometrial thickness is a prognostic factor in endometrial carcinoma." Bali Medical Journal 12, no. 2 (2023): 2083–87. http://dx.doi.org/10.15562/bmj.v12i2.4552.

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Background: Ultrasonography is a method that is commonly used today to measure endometrial thickness. It is useful as the initial step to detect endometrial hyperplasia or cancer in women with abnormal uterine bleeding. This study seeks to explore the predictive role of endometrial thickness in the development of endometrial cancer and identify the variables that affect endometrial thickness. Methods: This study is a cross sectional retrospective analytical study of women with a history of endometrial cancer who underwent transabdominal ultrasonography or transvaginal ultrasonography (TVS) fol

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Jongen, V. H. W. M., J. H. H. Thijssen, H. Hollema, et al. "Is aromatase cytochrome P450 involved in the pathogenesis of endometrioid endometrial cancer?" International Journal of Gynecologic Cancer 15, no. 3 (2005): 529–36. http://dx.doi.org/10.1136/ijgc-00009577-200505000-00019.

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Prospectively, the relationship between androgen levels in the utero-ovarian circulation, aromatase activity in endometrial and body fat tissue, and the presence or absence of endometrioid endometrial cancer was studied in postmenopausal women. In 43 women with endometrioid endometrial cancer and 8 women with a benign gynecological condition, a hysterectomy with bilateral salpingo-oophorectomy was performed. Using tritium water-release assays, aromatase activities in endometrial and body fat tissue were determined and related to the steroid levels from the peripheral and the utero-ovarian veno

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Kuru, Oguzhan, Ipek Betul Ozcivit Erkan, Cansu Turker Saricoban, Utku Akgor, Neslihan Gokmen Inan, and Sennur Ilvan. "The Role of Endometrial Sampling before Hysterectomy in Premenopausal Women with Abnormal Uterine Bleeding." Journal of Clinical Medicine 13, no. 13 (2024): 3709. http://dx.doi.org/10.3390/jcm13133709.

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Background/Objectives: An endometrial sampling is recommended for patients experiencing abnormal uterine bleeding above the age of 40 or 45. Valid risk prediction models are needed to accurately assess the risk of endometrial cancer and avoid an unnecessary endometrial biopsy in premenopausal women. We aimed to assess the necessity and usefulness of preoperative endometrial sampling by evaluating premenopausal women who underwent hysterectomy for abnormal uterine bleeding after preoperative endometrial sampling at our clinic. Methods: A retrospective analysis was conducted on 339 patients who

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Nandan, Neetha, Lakshmi Manjeera, Supriya Rai, and Mangala Gowri. "DIAGNOSTIC HYSTEROSCOPY IN ABNORMAL UTERINE BLEEDING & IT'S HISTOPATHOLOGIC CORRELATION: OUR EXPERIENCE." Journal of Health and Allied Sciences NU 03, no. 02 (2013): 013–17. http://dx.doi.org/10.1055/s-0040-1703646.

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Abstract Aims & objectives: 1) To study the accuracy of hysteroscopy in evaluation of abnormal uterine bleeding in perimenopausal and postmenopausal women. 2) To correlate hysteroscopic findings with histopathologic results. Materials and methods: It is a retrospective study done in the department of OBG at K. S.Hegde Medical Academy, Mangalore. All patients who underwent diagnostic hysteroscopy for abnormal uterine bleeding in the past 6 years were included in this study. Patients underwent clinical and sonographical evaluation. Following hysteroscopic evaluation, patients had undergone d

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Reske, Jake J., Mike R. Wilson, Jeanne Holladay, et al. "Co-existing TP53 and ARID1A mutations promote aggressive endometrial tumorigenesis." PLOS Genetics 17, no. 12 (2021): e1009986. http://dx.doi.org/10.1371/journal.pgen.1009986.

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TP53 and ARID1A are frequently mutated across cancer but rarely in the same primary tumor. Endometrial cancer has the highest TP53-ARID1A mutual exclusivity rate. However, the functional relationship between TP53 and ARID1A mutations in the endometrium has not been elucidated. We used genetically engineered mice and in vivo genomic approaches to discern both unique and overlapping roles of TP53 and ARID1A in the endometrium. TP53 loss with oncogenic PIK3CAH1047R in the endometrial epithelium results in features of endometrial hyperplasia, adenocarcinoma, and intraepithelial carcinoma. Mutant e

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Nivedita, Singh, and P. Dwivedi O. "Study of Histopathological Pattern of Endometrial Lesion in Abnormal Uterine Bleeding." International Journal of Pharmaceutical and Clinical Research 14, no. 10 (2022): 419–25. https://doi.org/10.5281/zenodo.13293049.

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<strong>Background:</strong> One of the most frequent presenting symptoms in the gynaecology out-patient department is abnormal uterine bleeding (AUB). When there is aberrant uterine bleeding without a known reason, it is referred to as dysfunctional uterine haemorrhage. For the patient with abnormal uterine bleeding to be managed effectively, an assessment of the endometrium’s histological pattern is necessary. Endometrial biopsy may be utilised successfully as the initial step in DUB diagnosis. <strong>Methods:</strong> In order to determine the endometrial aetiology of

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TANOS, V., I. ARIEL, D. PRUS, N. DE-GROOT, and A. HOCHBERG. "H19 and IGF2 gene expression in human normal, hyperplastic, and malignant endometrium." International Journal of Gynecologic Cancer 14, no. 3 (2004): 521–25. http://dx.doi.org/10.1136/ijgc-00009577-200405000-00015.

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We examined H19 and insulin-like growth factor 2 (IGF2) gene expression in normal endometrium (12 cases), hyperplasia (27 cases), and cancer (27 cases) by non-radioactivein situhybridization. H19 was not expressed in the epithelium of normal endometrium, but its frequency of expression was 15% in hyperplastic and 60% in neoplastic epithelium. In stroma cells, H19 frequency of expression was 75% in normal endometrium, 55% in hyperplasia, and 37% in carcinoma. According to the grade of endometrial cancer cell differentiation, H19 showed increased frequency and level of expression in the epitheli

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Watanabe, Koichi, Nobuyuki Kakiuchi, Kosuke Ieiri, et al. "Abstract 3895: Clonal expansion in normal endometrium and its association with endometriosis-associated ovarian cancer." Cancer Research 85, no. 8_Supplement_1 (2025): 3895. https://doi.org/10.1158/1538-7445.am2025-3895.

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[Introduction] Recent studies have revealed pervasive mutations affecting cancer-related genes in many normal tissues, including the endometrium, suggesting their role in cancer development. Endometriosis-associated ovarian cancer (EAOC) is thought to develop from endometriosis lesions seeded from endometrium to the ovary, although no solid evidence supports this. In this study, we sought to identify the clonal origin of EAOC by demonstrating ancestral clones of EAOC in the endometrium by detecting shared mutations between EAOC and endometrial clones. [Methods] We performed high-density sampli

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