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Relevant bibliographies by topics / Endothelioprotecive and cardioprotective activity

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Dissertations / Theses
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Academic literature on the topic 'Endothelioprotecive and cardioprotective activity'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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Journal articles on the topic "Endothelioprotecive and cardioprotective activity"

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Shakhno, Ekaterina, Tatyana Savitskaya, Tatyana Pokrovskaya, Vladimir Yakushev, Mikhail Pokrovskii, and Dmitry Grinshpan. "USE OF L-ARGININE IMMOBILISED ON ACTIVATED CARBON FOR PHARMACOLOGICAL CORRECTION OF ENDOTHELIAL DISFUNCTION." Research Results in Pharmacology 2, no. (1) (2016): 30–35. https://doi.org/10.18413/2313-8971-2016-2-1-30-35.

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For the first time a complex of L-arginine sodium salt of sulfate of cellulose acetate on activated carbon. To investigate the processes of sorption-desorption of L-arginine in a model environment. In animal experiments it was shown that granulirovannye the form of a combined preparation in dosages of 30 mg/kg, 70 mg/kg and 200 mg/kg exhibits a pronounced anti-hypertensive, endothelioprotecive and cardioprotective activity in a dosage of 200 mg/kg.

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Shakhno, Ekaterina, Tatyana Savitskaya, Tatyana Pokrovskaya, Vladimir Yakushev, and Dmitry Grinshpan. "NEW DOSAGE FORM OF L-ARGININE BASED ON ITS COMPLEX WITH CELLULOSE ACETATE SULFATE AND ACTIVATED CARBON." Research Results in Pharmacology 3, no. (2) (2017): 101–11. https://doi.org/10.18413/2313-8971-2017-3-2-101-111.

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Introduction: The oral route of L-arginine intake, despite its great comfort, is less effective in comparison with infusions. The development of new pharmaceutical forms for oral preparation is of undoubted interest. Objectives: To obtain a new dosage form of L-arginine by complexation with sodium salt of cellulose sulfate acetate (Na-CSA) followed by immobilization on activated carbon, and to evaluate its endothelial, cardioprotective and antihypertensive activity. Methods: UV-, visible spectroscopy, FTIR spectroscopy, viscometry, molecular mechanics, animal experiments with male Wistar albin

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Yakushev, Vladimir, Nikolaj Filippenko, Irina Kizilova, Mikhail Korokin, Evgeniya Beskhmelnitsyna, and Anna Litvinova. "STUDYING DOSE-DEPENDENT ENDOTHELIO- AND CARDIOPROTECTIVE ACTIVITY OF SELECTIVE ARGINASE II INHIBITOR IN HYPERHOMOCYSTEINE-INDUCED ENDOTHELIAL DYSFUNCTION." Research Results in Pharmacology 2, no. (1) (2016): 42–45. https://doi.org/10.18413/2313-8971-2016-2-1-42-45.

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This paper deals with the study of endothelio- and cardioprotective activity of arginase II selective inhibitor, the substance under the code ZB49-0010C in the model of hyperhomocysteine-induced endothelial dysfunction. The results of the studies prove the presence in the arginase II selective inhibitor, the substance under the code ZB49-0010C, dosedependent endothelioprotective and cardioprotective activity, which expression increases with the increase in dose and is maximum at a dose of 10 mg/kg. The research was partially supported by the grant of the President of the Russian Federation №MD

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Denisyuk, Tatiana. "PHARMACOTHERAPEUTIC STRATEGIES FOR ENDOTHELIAL DYSFUNCTION CORRECTION WITH USE OF STATINES IN SYNDROME OF SYSTEMIC INFLAMMATORY RESPONSE." Research Results in Pharmacology 3, no. (4) (2017): 35–77. https://doi.org/10.18413/2313-8971-2017-3-4-35-77.

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Objectives: The ways of pharmacological correction of cardiovascular complications in the syndrome of the systemic inflammatory response (SIRS) are not fully developed. Goal: Determination of statins' new pharmacological effects and its combination with endothelioprotectors in the SIRS correction. Methods: In experiments on mice, rats and rabbits, the anti-inflammatory, cardioprotective and endothelioprotective effects of statins and endothelioprotectors were explored. The modeling of endotoxin-induced endothelial dysfunction (EIED) was created by infecting rats with Staphylococcus aureus (str

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Tursunova, N. V., M. G. Klinnikova, O. A. Babenko, and E. L. Lushnikova. "Molecular mechanisms of the cardiotoxic action of anthracycline antibiotics and statin-induced cytoprotective reactions of cardiomyocytes." Biomeditsinskaya Khimiya 66, no. 5 (2020): 357–71. http://dx.doi.org/10.18097/pbmc20206605357.

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The manifestation of the side cardiotoxic effect of anthracycline antibiotics limits their use in the treatment of malignant processes in some patients. The review analyzes the main causes of the susceptibility of cardiomyocytes to the damaging effect of anthracyclines, primarily associated with an increase in the processes of free radical oxidation. Currently, research is widely carried out to find ways to reduce anthracycline cardiotoxicity, in particular, the use of cardioprotective agents in the complex treatment of tumors. Hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) ha

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Sun, Zhonghao, Zhaocui Sun, Daoshun Wu, et al. "Gram-Scale Total Synthesis of TAB with Cardioprotective Activity and the Structure-Activity Relationship of Its Analogs." Molecules 28, no. 13 (2023): 5197. http://dx.doi.org/10.3390/molecules28135197.

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Traditional Chinese medicine has been proven to be of great significance in cardioprotective effects. Clinopodium chinense (Lamiaceae) has unique advantages in the treatment and prevention of cardiovascular diseases. Tournefolic acid B (TAB) was proven to be a potent component against myocardial ischemia reperfusion injury (MIRI) from Clinopodium chinense (Lamiaceae). This article will attempt to establish a gram-scale synthesis method of TAB and discuss the structure-activity relationship of its analogs. The total synthesis of TAB was completed in 10 steps with an overall yield of 13%. In add

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Peltier, S., V. Novel-Chate, W. Malaisse, A. Molnar, X. Leverve, and R. Favier. "Cardioprotective Effect of Spontaneous Activity." International Journal of Sports Medicine 28, no. 12 (2007): 987–93. http://dx.doi.org/10.1055/s-2007-965070.

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Toffoli, Barbara, Stella Bernardi, Riccardo Candido, Serena Zacchigna, Bruno Fabris, and Paola Secchiero. "TRAIL shows potential cardioprotective activity." Investigational New Drugs 30, no. 3 (2011): 1257–60. http://dx.doi.org/10.1007/s10637-010-9627-8.

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Tarigan, Modesta Harmoni, Urip Harahap, Aminah Dalimunthe, and Nerdy Nerdy. "ANTIOXIDANT ACTIVITY AND CARDIOPROTECTIVE ACTIVITY OF BANGUN-BANGUN LEAVES (PLECTRANTHUS AMBOINICUS LOUR.) ETHANOLIC EXTRACT." Asian Journal of Pharmaceutical and Clinical Research 11, no. 9 (2018): 165. http://dx.doi.org/10.22159/ajpcr.2018.v11i9.26907.

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Objectives: The objectives of this study were to determine the antioxidant activity and cardioprotective activity of bangun-bangun leaves ethanolic extract.Methods: Bangun-bangun leaves ethanolic extract was obtained by maceration process. The antioxidant activity test was performed by 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) free radical scavenging method with various concentrations of extract. The absorbance was measured by visible spectrophotometric method and calculated the inhibitory concentration (IC50) value for antioxidant activity analysis. Cardioprotective activity test

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Kurniati, Neng Fisheri, and Yuthika Raihan Nadhirah. "Cardioprotective activity of Apples Juice on Isoproterenol-Induced Myocardial Infarction in Rat." Indonesian Journal of Pharmaceutical Science and Technology 10, no. 3 (2023): 154. http://dx.doi.org/10.24198/ijpst.v10i3.41445.

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Myocardial infarction was local necrosis of heart tissue due to reduced oxygen supply because of theocclusion of coronary arteries. Fruits could reduce the risk of developing obesity and CVDs. Severalstudies have shown that apples had a strong cardioprotective effect. This study aimed to understandthe cardioprotective activity of two variants of apples, e.g., Fuji and Malang, on isoproterenol-inducedmale Wistar rats. The cardioprotective activity test was carried out for 14 days, all testing group exceptnegative control, was induced by isoproterenol. The results of testing cardioprotective act

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Dissertations / Theses on the topic "Endothelioprotecive and cardioprotective activity"

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Buss, Joan L. "Mechanism of hydrolysis-activation of the cardioprotective antioxidant dexrazoxane and identification of more effective analogs by development of a quantitative structure-activity relationship describing imide hydrolysis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ31967.pdf.

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Barandier, Christine. "Potentiel thérapeutique du manganèse et de l'un de ses dérivés synthétiques sur le système cardiovasculaire." Université Joseph Fourier (Grenoble), 1998. http://www.theses.fr/1998GRE10238.

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Le present travail qui s'inscrit dans le cadre general des etudes consacrees a la protection pharmacologique des tissus cardiaque et vasculaire au cours de la reperfusion post-ischemique, comprend deux parties principales. La premiere a ete realisee sur un modele d'ischemie/reperfusion myocardique sur un modele experimental de coeur isole de rat. Les resultats sont exprimes en termes de donnees fonctionnelles, metaboliques et ultrastructurales. La seconde partie est une etude pharmacologique menee sur un modele d'anneaux d'aorte isolee de rat et comporte essentiellement des mesures de contract

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Chien, Yi-Wen, and 簡意文. "Comparison of the in vivo cardioprotective activity of cinnamophilin and quinidine in ischemia-reperfusion rats." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/74973708647340054904.

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碩士<br>國立臺灣大學<br>藥理學研究所<br>89<br>Abstract 1. Cinnamophilin (Cinn), which is non-alkaloid in nature, was found to have the capability to reverse coronary ligation-reperfusion induced ventricular arrhythmia to regular rhythm in isolated Langendorff perfused rat heart models. This action was proved to be related with its prolongation of APD50 and inhibition of potassium outward current and sodium inward current in isolated rat cardiac cell. 2. In animals, reperfusion of ischemic heart is associated with an excessive generation of free radicals which results in imbalance betwe

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Martinková, Pavla. "Antiproliferační aktivita nových analogů dexrazoxanu a jejich vliv na protinádorový účinek antracyklinů." Master's thesis, 2014. http://www.nusl.cz/ntk/nusl-333277.

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Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Bc. Pavla Martinková Supervisor: PharmDr. Anna Jirkovská, PhD. Title of diploma thesis: Antiproliferative activity of novel dexrazoxane analogues and their effect on antitumor effectiveness of anthracyclines Athracycline antibiotics (such as daunorubicin, doxorubicin or epirubicin) belong to the most common terapeutics of both solid tumors and hematological malignities. Unfortunately the serious and life-threatening adverse effect cardiotoxicity compromises their clinical usefulness

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Book chapters on the topic "Endothelioprotecive and cardioprotective activity"

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"Cardioprotective Plant Alkaloids: Ethnopharmacology, Structure Activity Relationship and Synthetic Analogues." In Herbal Medicine Back to the Future, edited by Abhijit Dey, Samapika Nandy, Anuradha Mukherjee, and Rabindranath Bhattacharyya. Bentham Science Publishers Ltd., 2017. http://dx.doi.org/10.2174/9781681084893117010009.

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Kumar Sahu, Pratap, and Prashant Tiwari. "Impact of Shodhana on Semecarpus anacardium Nuts." In Alternative Medicine - Update. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.94189.

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Semecarpus anacardium is classified in Ayurveda under the category of toxic plants. However, this toxic plant is reported to possess anti-inflammatory activity, anti-arthritic effect, antioxidant activity, antimicrobial activity, anti- carcinogenic activity, hypoglycemic activity, cardioprotective, hepatoprotective, neuroprotective, and hypolipidemic activity etc. All these activities are attributed to its various constituents like phenolic compounds, flavonoids, carbohydrates, alkaloids, steroids, etc. In Ayurveda, a series of pharmaceutical procedures which converts a poisonous drug into a s

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Sohail, Zoha, Noohela Khan, Mnahil Moazzam, et al. "Perspective Chapter: Beyond Delicious – The Hidden Functional Benefits of Cheese." In Recent Trends on Cheese As Functional Food With Great Nutritive and Health Benefits [Working Title]. IntechOpen, 2023. http://dx.doi.org/10.5772/intechopen.113047.

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Cheese; a diverse and healthy milkproduct with a long history that stretches back thousands of years. It is available worldwide in varying forms and is valued for its delicious taste and superior nutritional content. Classification of cheese is dependent on texture or moisture content, method of coagulation or coagulating agent, maturation or ripening, type of milk and manufacturing techniques. Cheese is comprised of macronutrients, micronutrients and functional nutrients; major macronutrients in cheese are proteins and fats, major micronutrients in cheese include vitamins and minerals and fun

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Gupta, Ena. "Elucidating the Phytochemical and Pharmacological Potential of Myristica fragrans (Nutmeg)." In Ethnopharmacological Investigation of Indian Spices. IGI Global, 2020. http://dx.doi.org/10.4018/978-1-7998-2524-1.ch004.

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Myristica fragrans or nutmeg is a ground spice of the family Myristicaceae. Its tree has dark leaves mainly cultivated in Grenada, Malaysia, and Kerala. It is majorly a source of two spices derived from its fruit: nutmeg (jaiphal) from its seed and mace (javitri) from the covering of seed. The important bioactive constituents present in nutmeg include macelignan, carvacrol, myristicin, β-caryophyllene, β-pinene, α-pinene, p-cymene, and eugenol. Low doses of nutmeg do not cause any side effects whereas after consuming 5g toxic overdose occurs, and central nervous system (CNS) effects were induc

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R., Vimalavathini, Sittarthan V., and Kavimani S. "Molecular Basis of Therapeutic Action of Flavonoids." In Therapeutic Insights into Herbal Medicine through the Use of Phytomolecules. BENTHAM SCIENCE PUBLISHERS, 2024. http://dx.doi.org/10.2174/9789815238129124030006.

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Herbs have been an integral part of human life for ages. Modern allopathic drugs had an upper hand over traditional medicine in the past century due to their mounting inefficacy, resistance, cost, and adverse effects that have led to the reclaim of herbs once again. Herbs holistically confer biological activity due to the presence of phytochemicals, which are classified broadly as carbohydrates, lipids, terpenoids, alkaloids, polyphenols, and essential and volatile oils. In this, polyphenols are a vast group further comprising flavonoids, phenolic acid, stilbenoids, tannins, lignans, xanthones

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Mahato, Harekrishna, and Brajesh Kumar. "Medicinal Uses with Immense Economic Potential and Nutritional Properties of Aegle marmelos: A Concise Review." In Biocomposites. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.102876.

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Aegle marmelos is the only member of the monotype genus Aegle and belongs to the Rutaceae family, the citrus fruits family. This review shows the economically feasible pharmacological applications and the nutritional properties of A. marmelos. Each part of the A. marmelos/Bael tree such as root, bark, leaf, flower, fruit, and seed has therapeutic significance in Ayurvedic systems as well as other traditional medicines. In bael fruit, there are various valuable bioactive compounds that have remarkable nutritional and medicinal properties. The isolated components belong to alkaloids, terpenoids,

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Krishnan, Mahalakshmi, Livya Catherene Martin, Parimalanandhini Duraisamy, et al. "An Overview of Natural Steroid Sources and their Therapeutic Profile." In Steroids and their Medicinal Potential. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/789815049336123010004.

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Natural steroids are organic compounds that play important physiological roles in various organisms. They are the key components of a cell, which act as important signalling molecules engaging in stress response, metabolic activities, reproduction, inflammation, and behavioural uniformities. Naturally, the human body embraces a cluster of steroids in the form of biological hormones, namely, sex hormones, adrenal cortical hormones and bile acids. Steroidal derivatives can imitate human hormones and exhibit their activities by boosting enzymes that the body lacks. Clinically, it is evident that

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Jennings, Catriona, Kathy Berra, Laura L. Hayman, et al. "Cardiovascular prevention and rehabilitation." In ESC Textbook of Cardiovascular Nursing, edited by Catriona Jennings, Felicity Astin, Donna Fitzsimons, Ekaterini Lambrinou, Lis Neubeck, and David R. Thompson. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780198849315.003.0011.

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There is a global imperative for the prevention of cardiovascular disease which includes primordial, primary, and secondary prevention. Prevention requires a multifactor risk reduction approach because of the multifaceted aetiology of cardiovascular disease. Components of cardiovascular disease prevention include behavioural strategies to encourage the adoption of healthy lifestyle habits (abstaining from tobacco, adopting a cardioprotective diet, achieving optimal physical activity and exercise levels, and achieving a healthy body weight and shape), the use of medications to manage biological

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Conference papers on the topic "Endothelioprotecive and cardioprotective activity"

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Soemijarto, Daniel Agustinus Teddy, I. Nyoman Ehrich Lister, and Sukirman Lie. "Reduction of Tropinin Levels in Rats through Cardioprotective Activity of Syzygium Polyanthum Ethanol Extract." In 2021 IEEE International Conference on Health, Instrumentation & Measurement, and Natural Sciences (InHeNce). IEEE, 2021. http://dx.doi.org/10.1109/inhence52833.2021.9537281.

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Papachristodoulou, A., K. Komianos, N. Psarras, et al. "The natural product Oleuropein shows enhanced anticancer and cardioprotective activity when co-administered in vivo with Doxorubicin." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3400098.

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Devarajan, Asokan, Dawoud Sulaiman, Feng Su, Ekambaram Ganapathy, Robin Farias-Eisner, and Srinivasa Reddy. "Abstract 3309: Cardioprotective paraoxonase 2 enhances the tumoricidal activity of natural killer cells in a paracrine manner." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-3309.

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Clemmer, John S., W. Andrew Pruett, and Robert L. Hester. "Simulating Baroreflex Activation Therapy for the Treatment of Heart Failure with Preserved Ejection Fraction." In 2022 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2022. http://dx.doi.org/10.1115/dmd2022-1043.

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Abstract Clinical trials demonstrate baroreflex activation therapy (BAT) reduces LV mass and blood pressure (BP) in hypertensive patients and in patients with hypertensive heart failure with preserved ejection fraction (HFpEF). It is thought that high sympathetic nerve activity (SNA) in the heart plays a role in the disease progression seen in these patients. However, the impact of BAT on hemodynamics, cardiac SNA, and disease progression during HFpEF is unknown. In the present study, we used HumMod, a large physiology model to predict the time-dependent changes of BAT during HFpEF. Our result

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Petrovic, Anica M., Jovana V. Bradic, and Vladimir Lj Jakovljevic. "The influence of the methanol extract of Galium verum on cardiac oxidative damage in hypertensive rats in a model of global ischemia." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.571p.

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Galium verum (G. verum, Lady ҆s bedstraw) is a perennial herbaceous plant that has been used for centuries as a sedative, an anticancer agent, in the treatment of gout, epilepsy, as antioxidant. Previous studies confirmed cardioprotective properties of this plant species extract in animal models of heart dysfunction, however, the impact of G. verum consumption on cardiac redox state in a condition of global ischemia has not been fully clarified. Therefore, our goal was to examine the effect of G. verum methanol extract on cardiac redox state in spontaneously hypertensive rats in the model of g

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