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Journal articles on the topic 'Endothelioprotecive and cardioprotective activity'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Shakhno, Ekaterina, Tatyana Savitskaya, Tatyana Pokrovskaya, Vladimir Yakushev, Mikhail Pokrovskii, and Dmitry Grinshpan. "USE OF L-ARGININE IMMOBILISED ON ACTIVATED CARBON FOR PHARMACOLOGICAL CORRECTION OF ENDOTHELIAL DISFUNCTION." Research Results in Pharmacology 2, no. (1) (2016): 30–35. https://doi.org/10.18413/2313-8971-2016-2-1-30-35.

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For the first time a complex of L-arginine sodium salt of sulfate of cellulose acetate on activated carbon. To investigate the processes of sorption-desorption of L-arginine in a model environment. In animal experiments it was shown that granulirovannye the form of a combined preparation in dosages of 30 mg/kg, 70 mg/kg and 200 mg/kg exhibits a pronounced anti-hypertensive, endothelioprotecive and cardioprotective activity in a dosage of 200 mg/kg.

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Shakhno, Ekaterina, Tatyana Savitskaya, Tatyana Pokrovskaya, Vladimir Yakushev, and Dmitry Grinshpan. "NEW DOSAGE FORM OF L-ARGININE BASED ON ITS COMPLEX WITH CELLULOSE ACETATE SULFATE AND ACTIVATED CARBON." Research Results in Pharmacology 3, no. (2) (2017): 101–11. https://doi.org/10.18413/2313-8971-2017-3-2-101-111.

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Introduction: The oral route of L-arginine intake, despite its great comfort, is less effective in comparison with infusions. The development of new pharmaceutical forms for oral preparation is of undoubted interest. Objectives: To obtain a new dosage form of L-arginine by complexation with sodium salt of cellulose sulfate acetate (Na-CSA) followed by immobilization on activated carbon, and to evaluate its endothelial, cardioprotective and antihypertensive activity. Methods: UV-, visible spectroscopy, FTIR spectroscopy, viscometry, molecular mechanics, animal experiments with male Wistar albin

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Yakushev, Vladimir, Nikolaj Filippenko, Irina Kizilova, Mikhail Korokin, Evgeniya Beskhmelnitsyna, and Anna Litvinova. "STUDYING DOSE-DEPENDENT ENDOTHELIO- AND CARDIOPROTECTIVE ACTIVITY OF SELECTIVE ARGINASE II INHIBITOR IN HYPERHOMOCYSTEINE-INDUCED ENDOTHELIAL DYSFUNCTION." Research Results in Pharmacology 2, no. (1) (2016): 42–45. https://doi.org/10.18413/2313-8971-2016-2-1-42-45.

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This paper deals with the study of endothelio- and cardioprotective activity of arginase II selective inhibitor, the substance under the code ZB49-0010C in the model of hyperhomocysteine-induced endothelial dysfunction. The results of the studies prove the presence in the arginase II selective inhibitor, the substance under the code ZB49-0010C, dosedependent endothelioprotective and cardioprotective activity, which expression increases with the increase in dose and is maximum at a dose of 10 mg/kg. The research was partially supported by the grant of the President of the Russian Federation №MD

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Denisyuk, Tatiana. "PHARMACOTHERAPEUTIC STRATEGIES FOR ENDOTHELIAL DYSFUNCTION CORRECTION WITH USE OF STATINES IN SYNDROME OF SYSTEMIC INFLAMMATORY RESPONSE." Research Results in Pharmacology 3, no. (4) (2017): 35–77. https://doi.org/10.18413/2313-8971-2017-3-4-35-77.

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Objectives: The ways of pharmacological correction of cardiovascular complications in the syndrome of the systemic inflammatory response (SIRS) are not fully developed. Goal: Determination of statins' new pharmacological effects and its combination with endothelioprotectors in the SIRS correction. Methods: In experiments on mice, rats and rabbits, the anti-inflammatory, cardioprotective and endothelioprotective effects of statins and endothelioprotectors were explored. The modeling of endotoxin-induced endothelial dysfunction (EIED) was created by infecting rats with Staphylococcus aureus (str

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Tursunova, N. V., M. G. Klinnikova, O. A. Babenko, and E. L. Lushnikova. "Molecular mechanisms of the cardiotoxic action of anthracycline antibiotics and statin-induced cytoprotective reactions of cardiomyocytes." Biomeditsinskaya Khimiya 66, no. 5 (2020): 357–71. http://dx.doi.org/10.18097/pbmc20206605357.

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The manifestation of the side cardiotoxic effect of anthracycline antibiotics limits their use in the treatment of malignant processes in some patients. The review analyzes the main causes of the susceptibility of cardiomyocytes to the damaging effect of anthracyclines, primarily associated with an increase in the processes of free radical oxidation. Currently, research is widely carried out to find ways to reduce anthracycline cardiotoxicity, in particular, the use of cardioprotective agents in the complex treatment of tumors. Hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) ha

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Sun, Zhonghao, Zhaocui Sun, Daoshun Wu, et al. "Gram-Scale Total Synthesis of TAB with Cardioprotective Activity and the Structure-Activity Relationship of Its Analogs." Molecules 28, no. 13 (2023): 5197. http://dx.doi.org/10.3390/molecules28135197.

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Traditional Chinese medicine has been proven to be of great significance in cardioprotective effects. Clinopodium chinense (Lamiaceae) has unique advantages in the treatment and prevention of cardiovascular diseases. Tournefolic acid B (TAB) was proven to be a potent component against myocardial ischemia reperfusion injury (MIRI) from Clinopodium chinense (Lamiaceae). This article will attempt to establish a gram-scale synthesis method of TAB and discuss the structure-activity relationship of its analogs. The total synthesis of TAB was completed in 10 steps with an overall yield of 13%. In add

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Peltier, S., V. Novel-Chate, W. Malaisse, A. Molnar, X. Leverve, and R. Favier. "Cardioprotective Effect of Spontaneous Activity." International Journal of Sports Medicine 28, no. 12 (2007): 987–93. http://dx.doi.org/10.1055/s-2007-965070.

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8

Toffoli, Barbara, Stella Bernardi, Riccardo Candido, Serena Zacchigna, Bruno Fabris, and Paola Secchiero. "TRAIL shows potential cardioprotective activity." Investigational New Drugs 30, no. 3 (2011): 1257–60. http://dx.doi.org/10.1007/s10637-010-9627-8.

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9

Tarigan, Modesta Harmoni, Urip Harahap, Aminah Dalimunthe, and Nerdy Nerdy. "ANTIOXIDANT ACTIVITY AND CARDIOPROTECTIVE ACTIVITY OF BANGUN-BANGUN LEAVES (PLECTRANTHUS AMBOINICUS LOUR.) ETHANOLIC EXTRACT." Asian Journal of Pharmaceutical and Clinical Research 11, no. 9 (2018): 165. http://dx.doi.org/10.22159/ajpcr.2018.v11i9.26907.

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Objectives: The objectives of this study were to determine the antioxidant activity and cardioprotective activity of bangun-bangun leaves ethanolic extract.Methods: Bangun-bangun leaves ethanolic extract was obtained by maceration process. The antioxidant activity test was performed by 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) free radical scavenging method with various concentrations of extract. The absorbance was measured by visible spectrophotometric method and calculated the inhibitory concentration (IC50) value for antioxidant activity analysis. Cardioprotective activity test

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Kurniati, Neng Fisheri, and Yuthika Raihan Nadhirah. "Cardioprotective activity of Apples Juice on Isoproterenol-Induced Myocardial Infarction in Rat." Indonesian Journal of Pharmaceutical Science and Technology 10, no. 3 (2023): 154. http://dx.doi.org/10.24198/ijpst.v10i3.41445.

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Myocardial infarction was local necrosis of heart tissue due to reduced oxygen supply because of theocclusion of coronary arteries. Fruits could reduce the risk of developing obesity and CVDs. Severalstudies have shown that apples had a strong cardioprotective effect. This study aimed to understandthe cardioprotective activity of two variants of apples, e.g., Fuji and Malang, on isoproterenol-inducedmale Wistar rats. The cardioprotective activity test was carried out for 14 days, all testing group exceptnegative control, was induced by isoproterenol. The results of testing cardioprotective act

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11

Ma, Yina, Jinli Wang, Junjie Gao, et al. "Antithrombin up-regulates AMP-activated protein kinase signalling during myocardial ischaemia/reperfusion injury." Thrombosis and Haemostasis 113, no. 02 (2015): 338–49. http://dx.doi.org/10.1160/th14-04-0360.

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SummaryAntithrombin (AT) is a protein of the serpin superfamily involved in regulation of the proteolytic activity of the serine proteases of the coagulation system. AT is known to exhibit anti-inflammatory and cardioprotective properties when it binds to heparan sulfate proteo - glycans (HSPGs) on vascular cells. AMP-activated protein kinase (AMPK) plays an important cardioprotective role during myocardial ischaemia and reperfusion (I/R). To determine whether the cardioprotective signaling function of AT is mediated through the AMPK pathway, we evaluated the cardioprotective activities of wil

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Kumar, Amith, Gopala Krishna, Prabha Hullatti, Tanmoy T, and Akshara A. "Indian Plants with Cardioprotective Activity – A Review." Systematic Reviews in Pharmacy 8, no. 1 (2016): 08–12. http://dx.doi.org/10.5530/srp.2017.1.3.

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13

Johnston, Cameron. "Ramipril: cardioprotective activity goes beyond BP reduction." Inpharma Weekly &NA;, no. 1327 (2002): 11–12. http://dx.doi.org/10.2165/00128413-200213270-00025.

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14

Koshma, Mallapu, V. Jaya Sankar Reddy, T. Naga Aditya, S. Jilani basha, Y. Sudha Rani, and P. Swaroopa. "CARDIOPROTECTIVE ACTIVITY OF MEDICINAL PLANTS: A REVIEW." International Research Journal of Pharmacy 8, no. 12 (2018): 4–11. http://dx.doi.org/10.7897/2230-8407.0812244.

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15

., Jude E. Okokon, and Bassey S. Antia . "Hypolipidaemic and Cardioprotective Activity of Mammea africana." Research Journal of Medicinal Plant 1, no. 4 (2007): 154–57. http://dx.doi.org/10.3923/rjmp.2007.154.157.

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16

Moreira Souza, Ana Carolina, Neila Marcia Silva Barcellos, Homero Nogueira Guimaraes, et al. "0109 : Increase liposomes cardioprotective activity of pyridostigmine." Archives of Cardiovascular Diseases Supplements 7, no. 2 (2015): 149. http://dx.doi.org/10.1016/s1878-6480(15)30052-5.

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17

Drapak, Iryna, Lina Perekhoda, Natalya Demchenko, et al. "Cardioprotective Activity of Some 2-Arylimino-1,3-Thiazole Derivatives." Scientia Pharmaceutica 87, no. 1 (2019): 7. http://dx.doi.org/10.3390/scipharm87010007.

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The article presents the synthesis of 2-arylimino-4-methyl-2,3-dihydro-1,3-thiazoles via Hantzsch reaction of thioureas and 3-chloropentane-2,4-dione or ethyl 2-chloro-3-oxobutanoate. The structure of synthesized compounds was confirmed by LCMS, 1H, and 13C NMR spectra. Cardioprotective activity of synthesized thiazole derivatives were studied in vitro on the isolated rings of the thoracic aorta of laboratory rats. Based on pharmacological studies, the tested compounds possessed a moderate to high cardioprotective effect. A prospective 1-[2-(4-methoxyphenylimino)-4-methyl-3-(4-methylpiperazine

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18

Khadse, Neha A., Manish P. Deshmukh, and Anjali M. Wankhade. "Cardioprotective Activity Of Herbal Formulation In Experimental Animal." American Journal of PharmTech Research 10, no. 5 (2020): 15–27. http://dx.doi.org/10.46624/ajptr.2020.v10.i5.002.

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19

Kalatanova, A. V., V. G. Makarov, N. M. Faustova, Ya I. Gushchin, and M. N. Makarova. "Evaluation of the cardioprotective effect of ubiquinol on the model of reperfusion injury of rat myocardium." Biomeditsinskaya Khimiya 64, no. 2 (2018): 188–94. http://dx.doi.org/10.18097/pbmc20186402188.

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The cardioprotective effect of ubiquinol on the model of myocardium reperfusion injury in rats was investigated. The study was carried out using mature males of outbred rats. Myocardial ischemia-reperfusion injury was performed after 30-minute ligation of the left coronary artery followed by reperfusion. The main criteria for assessing the development of pathology included the results of electrocardiography, biochemical analysis of blood plasma, histological and histochemical study of the myocardium. Development of the reperfusion damage of the myocardium caused specific changes in non-treated

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20

Atwal, Kamail S., and Gary J. Grover. "Treatment of Myocardial Ischemia with ATP-Sensitive Potassium Channel (KATP) Openers." Current Pharmaceutical Design 2, no. 5 (1996): 585–95. http://dx.doi.org/10.2174/1381612802666221004183709.

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ATP-sensitive potassium channel (KATP) openers are potent antihypertensive agents due to their peripheral vasodilating properties. Although KATP openers have been shown to be direct cardioprotective agents, they carry a certain degree of liability for their use as cardioprotective agents. Their potent coronary and peripheral vasodilating properties can cause complications such as coronary artery steal and hypotension resulting in underperfusion of the tissue already at risk. Also, cardioprotection is not related to action potential shortening and the development of agents devoid of this activi

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21

Zuurbier, Coert J., Otto Eerbeek, and Alfred J. Meijer. "Ischemic preconditioning, insulin, and morphine all cause hexokinase redistribution." American Journal of Physiology-Heart and Circulatory Physiology 289, no. 1 (2005): H496—H499. http://dx.doi.org/10.1152/ajpheart.01182.2004.

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Association of hexokinase (HK) with mitochondria preserves mitochondrial integrity and is an important mechanism by which cancer cells are protected against hypoxic conditions. Maintenance of mitochondrial integrity also figures prominently as a major characteristic of many cardioprotective manipulations. In this study, we provide evidence that cardioprotective interventions may promote HK redistribution from the cytosol to the mitochondria in the heart. Isolated Langendorff-perfused rat hearts ( n = 6/group) were subjected to normoxic perfusion (control, Con), three 5-min ischemia-reperfusion

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22

Karachentsev, A. N., V. G. Kukes, A. S. Kisrieva, and E. A. Mazerkina. "Cardiotropic activity of estrogens during hormone replacement therapy in postmenopausal women." Problems of Endocrinology 46, no. 1 (2000): 16–20. http://dx.doi.org/10.14341/probl11830.

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Cardiotropic activity of estrogens after a single administration and during 12-week substitute hormone therapy was studied during echocardiography and Doppler echocardiography in estrogen deficient women with natural or surgical postmenopause with negative cardiovascular (vasomotor) symptoms with hyperkinetic central hemodynamics, high arterial pressure, and disordered diastolic function of the left ventricle. The results confirm the cardioprotective and positive hemodynamic activity of substitute estrogens. Estrogens improved the initially disturbed diastolic and systolic function of the left

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23

Chiriapkin, A. S., D. S. Zolotykh, and D. I. Pozdnyakov. "Review of Biological Activity of Flavonoids: Quercetin and Kaempferol." Juvenis Scientia, no. 2 (April 30, 2023): 5–20. http://dx.doi.org/10.32415/jscientia_2023_9_2_5-20.

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Flavonoids are an extensive class of secondary metabolites present in varying concentrations in different parts of plants. Medicinal raw materials containing flavonoids have been used in traditional medicine in various countries for centuries and are also used in modern medicine for the production of drugs. Compared to other groups of secondary metabolites, flavonoids are often present in relatively large amounts. Interest in flavonoids is driven by constantly updated data on their biological activity and their wide distribution in the plant world. This review focuses on the two most commonly

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He, Yifei, Yu Fu, Mengyao Xi, et al. "Zn2+ and mPTP mediate resveratrol-induced myocardial protection from endoplasmic reticulum stress." Metallomics 12, no. 2 (2020): 290–300. http://dx.doi.org/10.1039/c9mt00264b.

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Aminabee, Sk Aminabee, K. Indraja K. Indraja, K. Matha Manogna, K. Naga Devika, K. Ramya Sri, and A. Lakshmana Rao. "Antioxidant and Cardioprotective Activity of Indigofera barberi on Doxorubicin Induced Toxicity on Rats." Biomedical and Pharmacology Journal 15, no. 3 (2022): 1299–309. http://dx.doi.org/10.13005/bpj/2467.

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Background: Worldwide, the major death causing diseases are cardiovascular diseases and today the need for herb based therapeutics is needed. Present study was undertaken the whole plant of Indigofera Barberi (IB) to evaluate its cardioprotective activity against cardiotoxicity on rats induced by Doxorubicin (DXR). Methods: Soxlet extraction was used to prepare extracts. Preliminary phytochemical tests and in-vitro antioxidant activity are the methods used for standardization of all the extracts. Chloroform extract of Indigofera barberi (CEIB) and aqueous extract of Indigofera barberi (AQIB) a

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Sangweni, Nonhlakanipho F., Kwazi Gabuza, Ruzayda van Aarde, et al. "Doxorubicin-Induced Cardiomyopathy: A Preliminary Study on the Cardioprotective Benefits of 7-Hydroxyflavanone." International Journal of Molecular Sciences 24, no. 20 (2023): 15395. http://dx.doi.org/10.3390/ijms242015395.

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The therapeutic properties of flavonoids are reported to offer cardioprotective benefits against doxorubicin (Dox)-induced cardiotoxicity (DIC). In the current study, we aimed to investigate the prophylactic properties of 7-hydroxyflavanone (7H), a flavonoid with antioxidative properties, against DIC. An in vitro model of DIC was established by exposing H9c2 cardiomyoblasts to Dox for 6 days. Similarly, cells were also co-treated with 7H to assess its ability to mitigate DIC. The data obtained indicate that 7H, as a co-treatment, alleviates Dox-induced oxidative stress by enhancing total gluta

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M, Ranjitha, Babu VLA, and Shwetha K. "Cardioprotective Activity of Nyctanthes arbor-tristis Linn Extract Loaded Nanoparticles." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 04 (2024): 1106–9. https://doi.org/10.25258/ijddt.14.4.26.

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The study targets to develop and evaluate nanoparticles loaded with Nyctanthes arbor-tristis Linn stem extracts for its cardioprotective activity. The Nyctanthes-arbor-tristis Linn stem was extracted by continuous hot percolation method using the soxhlet apparatus and subjected to phytochemical evaluation. Nanoparticles was developed by precipitation technique with zinc nitrate and sodium hydroxide and characterized by laser light transmission test, scanning electron microscopy and dynamic light scattering. The safety profile was performed as per OECD 423 guidelines. The cardioprotective activ

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Xiang, Zhi-Nan, Jun-Cheng Su, Yi-Hui Liu, et al. "Structurally diverse alkaloids from Buxus sempervirens with cardioprotective activity." Bioorganic Chemistry 109 (April 2021): 104753. http://dx.doi.org/10.1016/j.bioorg.2021.104753.

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29

M., Jalaiah, Sarvanan R., Gowtham C. H., Vinay Y., and Akhila Y. "EVALUATION OF CARDIOPROTECTIVE ACTIVITY OF ALLIUM CEPA AERIAL LEAVES." International Journal of Current Pharmaceutical Research 9, no. 6 (2017): 27. http://dx.doi.org/10.22159/ijcpr.2017v9i6.23424.

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Objective: The present work deals with the study of the ethanolic extract of fruits of Allium cepa aerial leaves for cardioprotective activity.Methods: Cardioprotective activity of the ethanolic extract of aerial leaves of Allium cepa was determined by the administration of isoproterenol (60 mg/kg, s. c) for two days.Results: Pretreatment with ethanolic extract of Allium cepa aerial leaves (200 mg/kg, p. o and 100 mg/kg, p. o) for 28 d in significantly (p<0.01) reduce the levels of serum transaminases, alkaline phosphates, lactate dehydrogenase, creatinine kinase, total cholesterol, triglyc

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Badole, Sachin L., Swapnil M. Chaudhari, Ganesh B. Jangam, Amit D. Kandhare, and Subhash L. Bodhankar. "Cardioprotective Activity ofPongamia pinnatain Streptozotocin-Nicotinamide Induced Diabetic Rats." BioMed Research International 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/403291.

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Pongamia pinnata(L.) Pierre has been used in traditional medicine for the treatment for diabetes and metabolic disorder. The aim of this study was to investigate the effect of petroleum ether extract of the stem bark ofP. pinnata(known as PPSB-PEE) on cardiomyopathy in diabetic rats. Diabetes was induced in overnight fasted Sprague-Dawley rats by using injection of streptozotocin (55 mg/kg, i.p.). Nicotinamide (100 mg/kg, i.p.) was administered 20 min before administration of streptozotocin. Rats were divided into group I: nondiabetic, group II: diabetic control (tween 80, 2%; 10 mL/kg, p.o.)

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Flores, Yvo, Gerald Zapata-Torres, Agustín Nuñez, et al. "Angiotensin-(1-9) Retro-Enantiomer Peptide With Cardioprotective Activity." Circulation 150, no. 10 (2024): 816–20. http://dx.doi.org/10.1161/circulationaha.122.061322.

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Tanwar, Ankur Kumar, and Meera K. Bhojani. "Network pharmacology approach to understand Kodo millet cardioprotective activity." Journal of Drug Research in Ayurvedic Sciences 9, no. 5 (2024): 319–24. https://doi.org/10.4103/jdras.jdras_227_23.

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Abstract BACKGROUND: Kodo millet, commonly referred to as “Varagu” or “Kodra” is a kind of millet that plays an important role in the Ayurveda nutritional concept. According to Ayurveda, nutrition is essential for sustaining health and preventing disease. Because of its nutritional richness and potential health benefits, Kodo millet has been used in Ayurveda since ancient times. However, the network’s pharmacology technique greatly aids in understanding the scientific use of any herb. METHODS: Network pharmacology is an interdisciplinary approach to understanding how drugs act within intricate

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Hu, Yu-Xia, Wei Zhang, Wen Zhang, et al. "Oleanane triterpene saponins with cardioprotective activity from Clinopodium polycephalum." Journal of Asian Natural Products Research 19, no. 7 (2016): 697–703. http://dx.doi.org/10.1080/10286020.2016.1254199.

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Wang, Di, Xin Zhang, Zhiying Bian, et al. "Multiple fingerprinting and cardioprotective activity of Salvia miltiorrhiza polysaccharides." International Journal of Biological Macromolecules 306 (May 2025): 141468. https://doi.org/10.1016/j.ijbiomac.2025.141468.

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Das, Samarjit, Saul R. Powell, Ping Wang, et al. "Cardioprotection with palm tocotrienol: antioxidant activity of tocotrienol is linked with its ability to stabilize proteasomes." American Journal of Physiology-Heart and Circulatory Physiology 289, no. 1 (2005): H361—H367. http://dx.doi.org/10.1152/ajpheart.01285.2004.

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Tocotrienols, isomers of vitamin E, have been found to possess many health benefits. The present study was designed to determine whether tocotrienol has a direct cardioprotective role. Isolated rat hearts were perfused for 15 min with Krebs-Ringer bicarbonate buffer in the absence or presence of palm tocotrienol derived from the tocotrienol-rich fraction (0.035%) of palm oil (TRF). In another group of studies, the hearts were preperfused for 15 min in the presence of a c-Src inhibitor, 4-amino-5-(4-methylphenyl)-7-( t-butyl)-pyrazolo-3,4- d-pyrimidine (PPI). The hearts were then subjected to 3

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Lukevics, E., P. Arsenyan, and M. Veveris. "Synthesis, Vasodilating, Antithrombotic and Cardioprotective Activity of Pyridyl Substituted 5-Silyl(Germyl)Isoxazolines-2." Metal-Based Drugs 5, no. 4 (1998): 251–57. http://dx.doi.org/10.1155/mbd.1998.251.

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The reactions of [2+3] cycloaddition of pyridylnitrile oxides to vinyl- and allylgermanes proceed regioselectively and afford 5-Ge-substituted isoxazolines-2. We have synthesized 9 new pyridyl substituted 5-Si(Ge)-isoxazolines-2 and investigated their biological activity. The vasodilating, anticoagulant and cardioprotective activities of 5-Si(Ge) substituted isoxazolines-2 have been studied in vitro and in vivo. Substitution of the silicon atom for the germanium one leads to the significant increase in vasodilating, antithrombotic and cardioprotective activity. The insertion of the methylene g

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P., Kavitha, and Sowmia C. "ANTIOXIDANT EFFECT OF POLYHERBAL FORMULATION IN ISOPRENALINE HYDROCHLORIDE INDUCED MYOCARDIAL INFARCTION IN RATS." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 10 (2017): 273. http://dx.doi.org/10.22159/ijpps.2017v9i10.20310.

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Objective: Myocardial infarction (MI) continues to be a major public health problem in the world. The prepared polyherbal formulation (PHF) exhibit cardioprotective effects by several mechanisms. The objective of the research was to evaluate the antioxidant effect of a polyherbal formulation in isoprenaline hydrochloride (ISO) induced myocardial infarction in rats.Methods: Oxidative stress and myocardial infarction was induced by administration of isoprenaline hydrochloride (25 mg/kg) for 2 d. The degree of protection was determined by measuring the levels of lipid peroxidation (LPO), enzymati

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Vishwakarma, Pinki, Manisha Chatterjee, Monica Sharma, Manish Saini, Rajkumar Goel, and K. K. Saxena. "Evaluation of Cardioprotective activity of Asparagus racemosus against Doxorubicin induced cardiotoxicity in albino rats: an experimental study." International Journal of Basic & Clinical Pharmacology 8, no. 7 (2019): 1693. http://dx.doi.org/10.18203/2319-2003.ijbcp20192673.

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Background: Cardiotoxicity is one of the most feared side effects of anticancer agents like Doxorubicin. Asparagus racemosus is a widely used medicinal plant in Indian system of medicine known for its antioxidant activity. In certain studies ethanol extract of Asparagus racemosus has shown to possess cardioprotective activity in experimental animals while in some other studies cardioprotective potential of Asparagus racemosus has not been demonstrated. Therefore, due to the controversial action, the present study was designed to explore the cardioprotective effect of aqueous effect of Asparagu

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Jovanović, Aleksandar. "Isosteviol: A potential cardioprotective agent." Arhiv za farmaciju 74, no. 5 (2024): 689–97. http://dx.doi.org/10.5937/arhfarm74-52624.

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Cardioprotection is a term describing the myocardial property to protect itself from injury, particularly in the context of ischemia-reperfusion injury and other metabolic stresses. Recently, isosteviol, a diterpene derived from the hydrolysis of stevioside, a natural sweetener found in the leaves of the Stevia rebaudiana plant, has emerged as a potential cardioprotective compound. In addition to the many therapeutic benefits of isosteviol, including antihyperglycemic, antihypertensive, and anti-inflammatory effects, recent studies have suggested that this compound might have cardioprotective

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Angelovski, Marija, Nikola Hadzi-Petrushev, Dino Atanasov, et al. "Protective Effects of L-2-Oxothiazolidine-4-Carboxylate during Isoproterenol-Induced Myocardial Infarction in Rats: In Vivo Study." Life 12, no. 10 (2022): 1466. http://dx.doi.org/10.3390/life12101466.

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This study aimed to evaluate the cardioprotective effects of L-2-oxothiazolidine-4-carboxylate (OTC) against isoproterenol (ISO)-induced acute myocardial infarction (MI) in rats. Results demonstrated that OTC treatments inhibited ISO-induced oxidative damage, suppressed lipid peroxidation, and increased superoxide dismutase and catalase activity in the hearts of the treated rats compared to those of the untreated controls. The ISO-related NF-κB activation was reduced due to the OTC treatment, and lower degrees of inflammatory cell infiltration and necrosis in the hearts were observed. In summa

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Panda, Vandana S., and Suresh R. Naik. "Cardioprotective effect of a chronic treatment of Ginkgo biloba Phytosomes in isoproterenol-induced cardiac necrosis in rats : Involvement of antioxidant system." Journal of Phytopharmacology 3, no. 4 (2014): 222–33. http://dx.doi.org/10.31254/phyto.2014.3401.

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The present study investigates the cardioprotective effect and antioxidant activity of a chronic treatment of Ginkgo biloba Phytosomes (GBP) in isoproterenol (ISO) induced cardiac necrosis in rats. Pretreatment of GBP 100 mg/kg daily for 30 & 45 days to rats treated with ISO (85 mg/kg, s.c) on the last 2 days, resulted in a significant cardioprotective activity reflected by attenuation of the ISO-elevated levels of serum marker enzymes (aspartate aminotransferase, lactate dehydrogenase & creatine phosphokinase) and malondialdehyde, and restoration of the activities and levels of the IS

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Wang, Yongyi, Min Men, Wengang Yang, Hui Zheng, and Song Xue. "MiR-31 Downregulation Protects Against Cardiac Ischemia/Reperfusion Injury by Targeting Protein Kinase C Epsilon (PKCe) Directly." Cellular Physiology and Biochemistry 36, no. 1 (2015): 179–90. http://dx.doi.org/10.1159/000374062.

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Background: Various miRNAs have been shown to participate in cardiac ischemia/reperfusion injury (I/R). miR-31 was identified as the most strikingly upregulated miRNA after acute myocardial infarction; therefore, the underlying role and mechanism of miR-31 in cardiac I/R was investigated. Methods: miR-31 expression was detected after cardiac I/R in mice. The cardioprotective effect of miR-31 downregulation was assessed in vitro and in vivo. The functional target gene and its downstream molecule were determined. Results: miR-31 expression increased after I/R. miR-31 downregulation increased cel

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Zanwar, Anand, Mahabaleshwar Hegde, and Subhash Bodhankar. "Cardioprotective activity of flax lignan concentrate extracted from seeds of Linum usitatissimum in isoprenalin induced myocardial necrosis in rats." Interdisciplinary Toxicology 4, no. 2 (2011): 90–97. http://dx.doi.org/10.2478/v10102-011-0016-8.

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Cardioprotective activity of flax lignan concentrate extracted from seeds ofLinum usitatissimumin isoprenalin induced myocardial necrosis in ratsThe objective of the study was to evaluate the cardioprotective activity of flax lignan concentrate (FLC) in isoprenalin (ISO) induced cardiotoxicity in rats. Male Wistar rats (200-230 g) were divided into three groups. Group I: control, Group II: isoprenalin, Group III: FLC (500 mg/kg, p.o.) orally for 8 days and in group II and III isoprenalin 5.25 mg/kg, s.c. on day 9 and 8.5 mg/kg on day 10. On day 10 estimation of marker enzymes in serum and haem

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Franklin, Barry A., and Sae Young Jae. "Physical Activity, Cardiorespiratory Fitness and Atherosclerotic Cardiovascular Disease: Part 1." Pulse 12, no. 1 (2024): 113–25. http://dx.doi.org/10.1159/000541165.

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Background: The cardioprotective benefits and prognostic significance of regular moderate-to-vigorous physical activity (PA), increased cardiorespiratory fitness (CRF), or both are often underappreciated by the medical community and the patients they serve. Individuals with low CRF are two to three times more likely to die prematurely from atherosclerotic cardiovascular disease (CVD), than their fitter counterparts when matched for risk factor profile or coronary artery calcium (CAC) score. Accordingly, part 1 of this 2-part review examines these relations and the potential underlying mechanis

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Castoldi, Giovanna, Raffaella Carletti, Silvia Ippolito, et al. "Cardioprotective Effects of Sodium Glucose Cotransporter 2 Inhibition in Angiotensin II-Dependent Hypertension Are Mediated by the Local Reduction of Sympathetic Activity and Inflammation." International Journal of Molecular Sciences 24, no. 13 (2023): 10710. http://dx.doi.org/10.3390/ijms241310710.

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The cardioprotective effects of sodium glucose cotrasponter 2 (SGLT2) inhibitors seem to be independent from the effects on glycemic control, through little-known mechanisms. In this study, we investigate whether the cardioprotective effects of empagliflozin, a SGLT2 inhibitor, may be associated with myocardial sympathetic activity and inflammatory cell infiltration in an experimental model of angiotensin II-dependent hypertension. Angiotensin II (Ang II), Ang II plus Empagliflozin, physiological saline, or physiological saline plus empagliflozin were administered to Sprague Dawley rats for tw

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Plaza, Andrea, Lyanne Rodríguez, Anibal A. Concha-Meyer, et al. "Effects of Extraction Methods on Phenolic Content, Antioxidant and Antiplatelet Activities of Tomato Pomace Extracts." Plants 12, no. 5 (2023): 1188. http://dx.doi.org/10.3390/plants12051188.

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Aqueous and ethanolic extracts of tomato pomace were examined with the aim of optimizing the extraction process of compounds with cardioprotective activity. Once the results of the ORAC response variables, total polyphenols, °Brix, and antiplatelet activity of the extracts were obtained, a multivariate statistical analysis was performed using the Statgraphics Centurion XIX software. This analysis showed that the most relevant positive effects in the inhibition of platelet aggregation were 83 ± 2% when using the agonist TRAP-6, when the working conditions were the type of tomato pomace conditio

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Treviño-Saldaña, Niria, and Gerardo García-Rivas. "Regulation of Sirtuin-Mediated Protein Deacetylation by Cardioprotective Phytochemicals." Oxidative Medicine and Cellular Longevity 2017 (2017): 1–16. http://dx.doi.org/10.1155/2017/1750306.

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Modulation of posttranslational modifications (PTMs), such as protein acetylation, is considered a novel therapeutic strategy to combat the development and progression of cardiovascular diseases. Protein hyperacetylation is associated with the development of numerous cardiovascular diseases, including atherosclerosis, hypertension, cardiac hypertrophy, and heart failure. In addition, decreased expression and activity of the deacetylases Sirt1, Sirt3, and Sirt6 have been linked to the development and progression of cardiac dysfunction. Several phytochemicals exert cardioprotective effects by re

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Divya, B., S. Shivashree, K. Mruthunjaya, and S. N. Manjula. "Cardioprotective activity of Lawsonia inermis roots against Doxorubicin Treated Mice." Research Journal of Pharmacy and Technology 13, no. 7 (2020): 3279. http://dx.doi.org/10.5958/0974-360x.2020.00581.8.

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Chauhan, Gauri Madhav, and Suresh R. Naik. "Cardioprotective Activity of A.V. Circulo in Isoproterenol-Induced Myocardial Necrosis." Journal of Herbal Pharmacotherapy 5, no. 4 (2005): 51–61. http://dx.doi.org/10.1080/j157v05n04_06.

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Chauhan, Gauri Madhav, and Suresh Naik. "Cardioprotective Activity of A.V. Circulo in Isoproterenol-Induced Myocardial Necrosis." Journal Of Herbal Pharmacotherapy 5, no. 4 (2006): 51–61. http://dx.doi.org/10.1300/j157v05n04_06.

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