Log in

Relevant bibliographies by topics / Epi-isomers / Journal articles

To see the other types of publications on this topic, follow the link: Epi-isomers.

Journal articles on the topic 'Epi-isomers'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 36 journal articles for your research on the topic 'Epi-isomers.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Son, Heebin, Keumhan Noh, InWha Park, et al. "Stereo-Selective Pharmacokinetics of Ilimaquinone Epimers Extracted from a Marine Sponge in Rats." Marine Drugs 17, no. 3 (2019): 171. http://dx.doi.org/10.3390/md17030171.

Full text

Abstract:

An ilimquinone (IQ) mixture isolated from Hippiospongia metachromia, consisting of IQ and epi-ilimaquinone (epi-IQ), exerts anti-HIV, anti-microbial, anti-inflammatory, and anti-cancer effects. An HPLC-MS/MS method was developed for simultaneous determination of the two epimers in rat plasma, separating them using a biphenyl column. Ascorbic acid is added during the sample preparation to ensure the stability of both isomers. The plasma concentrations of the isomers were monitored following intravenous and oral administration of the IQ mixture in rats as well as the individual epimers that were

APA, Harvard, Vancouver, ISO, and other styles

2

Tanase, Constantin, Denisa Ioana Udeanu, Constantin Draghici, and Florea Cocu. "Synthesis and Characterization of 1-Ethylamide and 1-Ethanolamide of D-Cloprostenol and their 15-Epimers." Revista de Chimie 69, no. 12 (2019): 3349–52. http://dx.doi.org/10.37358/rc.18.12.6747.

Full text

Abstract:

1-Ethylamide-, 1-ethanolamide of D-Cloprostenol and their 15-epi-isomers were synthesized by amidation of methyl esters of D-Cloprostenol or 15-epi-Cloprostenol. The crude compounds were purified by pressure chromatography on silica gel and fully characterized by IR, 1H-, 13C-, 2D-NMR (COSY and HETCOR) and MS spectroscopy.

APA, Harvard, Vancouver, ISO, and other styles

3

Sudhakar, Gangarajula, Karla Janardhan Reddy, and Jagadeesh Babu Nanubolu. "Total synthesis of palmyrolide A and its 5,7-epi isomers." Tetrahedron 69, no. 11 (2013): 2419–29. http://dx.doi.org/10.1016/j.tet.2013.01.048.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Rabe, Patrick, and Jeroen S. Dickschat. "The EIMS fragmentation mechanisms of the sesquiterpenes corvol ethers A and B, epi-cubebol and isodauc-8-en-11-ol." Beilstein Journal of Organic Chemistry 12 (July 5, 2016): 1380–94. http://dx.doi.org/10.3762/bjoc.12.132.

Full text

Abstract:

Farnesyl diphosphate (FPP) and all fifteen positional isomers of (13C1)FPP were enzymatically converted by the bacterial terpene cyclases corvol ether synthase from Kitasatospora setae, the epi-cubebol synthase from Streptosporangium roseum, and the isodauc-8-en-11-ol synthase from Streptomyces venezuelae. The enzyme products were analysed by GC–MS and GC–QTOF MS2 and the obtained data were used to delineate the EIMS fragmentation mechanisms of the two sesquiterpene ethers corvol ethers A and B, and the sesquiterpene alcohols epi-cubebol and isodauc-8-en-11-ol.

APA, Harvard, Vancouver, ISO, and other styles

5

Aparna, Das. "Quantitative structure-property relationships of Taxol, Taxotere and their epi-isomers." Journal of Indian Chemical Society Vol. 97, No. 11b, Nov 2020 (2020): 2468–76. https://doi.org/10.5281/zenodo.5656707.

Full text

Abstract:

Department of Mathematics and Natural Sciences, College of Sciences and Human Studies, Prince Mohammad Bin Fahd University, Al Khobar 31952, Kingdom of Saudi Arabia <em>E</em>-<em>mail:</em> aparnadasam@gmail.com, adas@pmu.edu.sa <em>Manuscript received online 20 October 2020, revised and accepted 31 November 2020</em> The current study investigates the importance of molecular structure analysis based on density functional theory (DFT) with a focus on Taxol, Taxotere, and related compounds. Numerous physicochemical parameters of these compounds with respect to their biological activity are cal

APA, Harvard, Vancouver, ISO, and other styles

6

An, Xiaosheng, and Yikang Wu. "Synthesis of (+)-Panamonon B, 7-epi-Panamonon B, and Their (Z)-Isomers." Journal of Organic Chemistry 86, no. 17 (2021): 11948–59. http://dx.doi.org/10.1021/acs.joc.1c01344.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Chen, Jie, Yang Li, and Xiao-Ping Cao. "First stereoselective synthesis of serinol-derived malyngamides and their 1′-epi-isomers." Tetrahedron: Asymmetry 17, no. 6 (2006): 933–41. http://dx.doi.org/10.1016/j.tetasy.2006.02.027.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Sehaki, Chabha, Roland Molinie, David Mathiron, et al. "Metabolomics-Based Profiling via a Chemometric Approach to Investigate the Antidiabetic Property of Different Parts and Origins of Pistacia lentiscus L." Metabolites 13, no. 2 (2023): 275. http://dx.doi.org/10.3390/metabo13020275.

Full text

Abstract:

Pistacia lentiscus L. is a medicinal plant that grows spontaneously throughout the Mediterranean basin and is traditionally used to treat diseases, including diabetes. The aim of this work consists of the evaluation of the α-glucosidase inhibitory effect (i.e., antidiabetic activity in vitro) of different extracts from the leaves, stem barks and fruits of P. lentiscus harvested on mountains and the littoral of Tizi-Ouzou in Algeria. Metabolomic profiling combined with a chemometric approach highlighted the variation of the antidiabetic properties of P. lentiscus according to the plant’s part a

APA, Harvard, Vancouver, ISO, and other styles

9

Braun, Norbert A., Jean-François Butaud, Jean-Pierre Bianchini, et al. "Eastern Polynesian Sandalwood Oil (Santalum insulare Bertero ex A. DC.) – a Detailed Investigation." Natural Product Communications 2, no. 6 (2007): 1934578X0700200. http://dx.doi.org/10.1177/1934578x0700200615.

Full text

Abstract:

Three qualities of Eastern Polynesian sandalwood oil were analyzed using GC and GC-MS. Sixty-six constituents were identified: 5 monoterpenes, 58 sesquiterpenes and 3 others. The main constituents of the essential oils were ( Z)-α-santalol and ( Z)-β-santalol. Beside chemical composition, olfactory evaluation and chiral gas chromatography of β- and epi-β-bisabolol isomers confirmed the close relationship of Eastern Polynesian to East Indian and New Caledonian sandalwood oil.

APA, Harvard, Vancouver, ISO, and other styles

10

Martins, Júlia, Joana Coelho, Maraine Catarina Tadini, et al. "Yangambin and Epi-yangambin Isomers: New Purification Method from Ocotea fasciculata and First Cytotoxic Aspects Focusing on In Vivo Safety." Planta Medica 86, no. 06 (2020): 415–24. http://dx.doi.org/10.1055/a-1118-3828.

Full text

Abstract:

Abstract Ocotea fasciculata presents yangambin (YAN) and its isomer epi-yangambin (EPI-YAN) as major lignans, which are employed as the plant markers for quality control purposes and as potential pharmacological compounds. However, a gap between the pure isomers and safety and efficacy protocols is faced by the scientific community. In this context, this work aimed to report (i) a new and advantageous purifying process in a semi-preparative scale for YAN and EPI-YAN isolation from Ocotea fasciculata, and (ii) an in vitro cytotoxicity study to estimate, for the first time, the LD50 values of th

APA, Harvard, Vancouver, ISO, and other styles

11

Malik, Sohail, and Klaus Albert. "Structural Studies on Vindolinine." Zeitschrift für Naturforschung B 41, no. 3 (1986): 386–92. http://dx.doi.org/10.1515/znb-1986-0316.

Full text

Abstract:

19-S-Vindolinine has been found to undergo an interesting isomerisation in chloroform to 19-R-vindolinine at room temperature. NOEDS measurements have been carried out on both isomers and a 13C solid state CP-MAS spectrum recorded for 19-S-vindolininc. The structure assigned as 16-epi-19-S-vindolinine to an alkaloid isolated previously from Catharanthus roseus has been revised in the light of corrected 13C NMR values for 19-S- and 19-R-vindolinine.

APA, Harvard, Vancouver, ISO, and other styles

12

Dowd, MK, AD French, and PJ Reilly. "MM3(92) Analysis of Inositol Ring Puckering." Australian Journal of Chemistry 49, no. 3 (1996): 327. http://dx.doi.org/10.1071/ch9960327.

Full text

Abstract:

The molecular mechanics method MM3(92) was used to study the puckering of the nine inositol isomers. Energy surfaces were generated based on the Cremer-Pople puckering definitions and the geometric plate carree representations of Pickett and Strauss. Chair forms are favoured for all the inositol isomers in agreement with experiment. The lowest energy non-chair form, more than 10 kJ/mol in free energy above the chair, is a skew of muco-inositol , in which all the hydroxyls are oriented either equatorially or pseudo-equatorially. Hydrogen-hydrogen coupling constants are in good agreement with ex

APA, Harvard, Vancouver, ISO, and other styles

13

Moiteiro, Cristina, Teresa Esteves, Luís Ramalho, et al. "Essential Oil Characterization of Two Azorean Cryptomeria japonica Populations and Their Biological Evaluations." Natural Product Communications 8, no. 12 (2013): 1934578X1300801. http://dx.doi.org/10.1177/1934578x1300801233.

Full text

Abstract:

Essential oils from foliage, bark and heartwood of Cryptomeria japonica D. Don from Azores Archipelago (Portugal) were analyzed by GC and GC-MS. Two populations, of black and reddish heartwood color, were studied. The main compounds found in the foliage of both populations were α-pinene (9.6–29.5%), (+)-phyllocladene (3.5–26.5%), ent-kaur-16-ene (0.2–20.6%), sabinene (0.5–19.9%) and limonene (1.4–11.5%), with a large variation in individual compounds from each population. Heartwood oils were characterized by a high content of cubebol (2.8–39.9%) and epi-cubebol (4.1–26.9%) isomers, which were

APA, Harvard, Vancouver, ISO, and other styles

14

Taylor, Wesley F., Maria Yanez, Sara E. Moghadam, et al. "7-epi-Clusianone, a Multi-Targeting Natural Product with Potential Chemotherapeutic, Immune-Modulating, and Anti-Angiogenic Properties." Molecules 24, no. 23 (2019): 4415. http://dx.doi.org/10.3390/molecules24234415.

Full text

Abstract:

Targeted therapies have changed the treatment of cancer, giving new hope to many patients in recent years. The shortcomings of targeted therapies including acquired resistance, limited susceptible patients, high cost, and high toxicities, have led to the necessity of combining these therapies with other targeted or chemotherapeutic treatments. Natural products are uniquely capable of synergizing with targeted and non-targeted anticancer regimens due to their ability to affect multiple cellular pathways simultaneously. Compounds which provide an additive effect to the often combined immune ther

APA, Harvard, Vancouver, ISO, and other styles

15

de Moura, Patricia Homobono Brito, Amaryllis Almeida de Sousa, Andrea Porzel, Ludger A. Wessjohann, Ivana Correa Ramos Leal, and Roberto Carlos Campos Martins. "Characterization of Antibacterial Proanthocyanidins of Dalbergia monetaria, an Amazonian Medicinal Plant, by UHPLC-HRMS/MS." Planta Medica 86, no. 12 (2020): 858–66. http://dx.doi.org/10.1055/a-1170-8016.

Full text

Abstract:

Abstract Dalbergia monetaria is an Amazonian plant whose bark is widely used to treat urinary tract infections. This paper describes a bio-guided study of ethanolic extracts from the bark and leaves of D. monetaria, in a search for metabolites active against human pathogenic bacteria. In vitro assays were performed against 10 bacterial strains, highlighting methicillin-sensitive Staphylococcus aureus and methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa. Fractioning of the extracts was performed using instrumental and classical techniques, and samples were characterized by

APA, Harvard, Vancouver, ISO, and other styles

16

Chi, Junxi, Jiahao Cheng, Shang Wang, Cheng Li, and Ming Chen. "Promising Anti-Inflammatory Tools: Biomedical Efficacy of Lipoxins and Their Synthetic Pathways." International Journal of Molecular Sciences 24, no. 17 (2023): 13282. http://dx.doi.org/10.3390/ijms241713282.

Full text

Abstract:

Lipoxins (LXs) have attracted widespread attention as a class of anti-inflammatory lipid mediators that are produced endogenously by the organism. LXs are arachidonic acid (ARA) derivatives that include four different structures: lipoxin A4 (LXA4), lipoxin B4 (LXB4), and the aspirin-induced differential isomers 15-epi-LXA4 and 15-epi-LXB4. Because of their unique biological activity of reducing inflammation in the body, LXs have great potential for neuroprotection, anti-inflammatory treatment of COVID-19, and other related diseases. The synthesis of LXs in vivo is achieved through the action o

APA, Harvard, Vancouver, ISO, and other styles

17

Jain, Vipin Kumar, та Mrityunjay Kumar. "Synthesis of (–)-Bulgecinine and 5-epi-Bulgecinine through Proline-Catalysed Asymmetric α-Hydroxylation of an Aldehyde Derived from l-Glutamic Acid". SynOpen 03, № 04 (2019): 96–102. http://dx.doi.org/10.1055/s-0039-1690332.

Full text

Abstract:

A very efficient synthetic route to (–)-bulgecinine and 5-epibulgecinine from an aldehyde derived from l-glutamic acid is reported. Proline-catalysed asymmetric α-hydroxylation reaction of an aldehyde is the key step in this synthesis, which is used to incorporate a hydroxyl group at the α-position to that aldehyde in good yield and with very high diastereoselectivity. Both (–)-bulgecinine and 5-epi-bulgecinine are synthesised from the same olefin via epoxidation followed by BF3·OEt2-catalyzed intramolecular cyclisation. This synthetic route can easily be extended for the synthesis of the enan

APA, Harvard, Vancouver, ISO, and other styles

18

Barrero, Alejandro F., Juan F. Sánchez, Nuria Ferrol та A. San Feliciano. "Conformational isomers of 14-hydroxy-9-epi-β-caryophyllene isolated from the wood of Juniperus oxycedrus". Tetrahedron Letters 30, № 2 (1989): 247–50. http://dx.doi.org/10.1016/s0040-4039(00)95172-4.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Zerbib, Marie, Guillaume Cazals, Marie-Agnès Ducasse, Christine Enjalbal, and Cédric Saucier. "Evolution of Flavanol Glycosides during Red Grape Fermentation." Molecules 23, no. 12 (2018): 3300. http://dx.doi.org/10.3390/molecules23123300.

Full text

Abstract:

Monomeric and dimeric flavanol glycosides were quantified by UHPLC-MRM in Syrah (SYR) and Grenache (GRE) grapes and in their corresponding wines for the first time. Quantities were extremely variable depending on grape tissue (seeds or skins) and during fermentation. Overall, 22 monomeric and dimeric mono- and diglycosides were determined with concentrations ranging from 0.7 nanograms to 0.700 micrograms per gram of grape tissue, and 0 to 60 micrograms per liter for wines. The evolution of the glycosides’ composition during winemaking suggests that almost all these compounds originate in the g

APA, Harvard, Vancouver, ISO, and other styles

20

Zomborszki, Zoltán Péter, Norbert Kúsz, Judit Hohmann, and Dezső Csupor. "Three novel constituents from the roots of Rhaponticum carthamoides." Acta Pharmaceutica Hungarica 93 (2023): 9–14. https://doi.org/10.33892/aph.2023.93.9-14.

Full text

Abstract:

Aims: The purpose of our study was to conduct a phytochemical analysis of Rhaponticum carthamoides in order to gain a better understanding of its chemical profile and the active constituents responsible for its bioactivities. Methods: The methanolic extract of the root was fractionated using multiple chromatographic methods, including normal, medium and high-pressure chromatography, rotation planar chromatography with a variety of stationary phases and eluents. The structures of the isolated compounds were identified by comparing their NMR spectra with those reported in the literature. Results

APA, Harvard, Vancouver, ISO, and other styles

21

Angelopoulou, Dimitra, Costas Demetzos, Costas Dimas, Dimitrios Perdetzoglou, and Anargyros Loukis. "Essential Oils and Hexane Extracts from Leaves and Fruits of Cistus monspeliensis. Cytotoxic Activity of ent-13-epi-Manoyl Oxide and its Isomers." Planta Medica 67, no. 2 (2001): 168–71. http://dx.doi.org/10.1055/s-2001-11497.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

López-Gambero, Antonio J., Carlos Sanjuan, Pedro Jesús Serrano-Castro, Juan Suárez, and Fernando Rodríguez de Fonseca. "The Biomedical Uses of Inositols: A Nutraceutical Approach to Metabolic Dysfunction in Aging and Neurodegenerative Diseases." Biomedicines 8, no. 9 (2020): 295. http://dx.doi.org/10.3390/biomedicines8090295.

Full text

Abstract:

Inositols are sugar-like compounds that are widely distributed in nature and are a part of membrane molecules, participating as second messengers in several cell-signaling processes. Isolation and characterization of inositol phosphoglycans containing myo- or d-chiro-inositol have been milestones for understanding the physiological regulation of insulin signaling. Other functions of inositols have been derived from the existence of multiple stereoisomers, which may confer antioxidant properties. In the brain, fluctuation of inositols in extracellular and intracellular compartments regulates ne

APA, Harvard, Vancouver, ISO, and other styles

23

de Sousa Dias, Aécio L., Arnaud Verbaere, Emmanuelle Meudec, et al. "Improved Analysis of Isomeric Polyphenol Dimers Using the 4th Dimension of Trapped Ion Mobility Spectrometry—Mass Spectrometry." Molecules 27, no. 13 (2022): 4176. http://dx.doi.org/10.3390/molecules27134176.

Full text

Abstract:

Dehydrodicatechins resulting from (epi)catechin oxidation have been investigated in different foods and natural products, but they still offer some analytical challenges. The purpose of this research is to develop a method using ultra-high performance liquid chromatography coupled with trapped ion mobility spectrometry and tandem mass spectrometry (UHPLC−ESI−TIMS−QTOF−MS/MS) to improve the characterization of dehydrodicatechins from model solutions (oxidation dimers of (+)-catechin and/or (−)-epicatechin). Approximately 30 dehydrodicatechins were detected in the model solutions, including dehy

APA, Harvard, Vancouver, ISO, and other styles

24

Taraj Lulja, Krenaida, and Mary Mrad - Hage. "Metabolic Profiling of Metoprolol via HPLC Coupled with ESI - QqQLIT Mass Spectrometry." Technium BioChemMed 13 (April 25, 2025): 72–92. https://doi.org/10.47577/biochemmed.v13i.12710.

Full text

Abstract:

Metoprolol, a selective β₁-adrenergic antagonist, is widely prescribed for the treatment of hypertension and heart failure due to its proven mortality benefits. With the expected rise in cardiovascular diseases, understanding the metabolic fate of metoprolol is crucial for assessing its safety, efficacy, and pharmacokinetics. This study aimed to elucidate the in vitro metabolic pathways of metoprolol using High-Performance Liquid Chromatography coupled with Electrospray Ionization and hybrid Triple Quadrupole–Linear Ion Trap Mass Spectrometry (HPLC-ESI-QqQLIT-MS). Metabolism was simulated usin

APA, Harvard, Vancouver, ISO, and other styles

25

Jin, Zhicheng, Roger Bertholf та Xin Yi. "Quantitation of 1α,25-Dihydroxyvitamin D by Liquid Chromatography-Tandem Mass Spectrometry without immunoextraction". American Journal of Clinical Pathology 156, Supplement_1 (2021): S17—S18. http://dx.doi.org/10.1093/ajcp/aqab189.031.

Full text

Abstract:

Abstract Objective The objective is to develop a LC-MS/MS method to quantify 1α,25-dihydroxyvitamin D without using antibody-based extraction procedure. Methods Vitamin D is a lipid-soluble micronutrient that regulates calcium and phosphate absorption. 25-Hydroxyvitamin D is the primary form in circulation and 1α,25-dihydroxyvitamin D (DHVD) is the biologically active form. DHVD assay is challenging because of very low concentrations (picomolar) and numerous isomers or epimers present in serum. Solid phase extraction and Cookson-type triazolinedione derivatization of vitamin D increases the an

APA, Harvard, Vancouver, ISO, and other styles

26

Vederas, John C. "2005 Alfred Bader Award Lecture Diaminopimelate and lysine biosynthesis - An antimicrobial target in bacteria." Canadian Journal of Chemistry 84, no. 10 (2006): 1197–207. http://dx.doi.org/10.1139/v06-072.

Full text

Abstract:

The development of bacterial resistance to current antibiotic therapy has stimulated the search for novel antimicrobial agents. The essential peptidoglycan cell wall layer in bacteria is the site of action of many current drugs, such as β-lactams and vancomycin. It is also a target for a number of very potent bacterially produced antibiotic peptides, such as nisin A and lacticin 3147, both of which are highly posttranslationally modified lantibiotics that act by binding to lipid II, the peptidoglycan precursor. Another set of potential targets for antibiotic development are the bacterial enzym

APA, Harvard, Vancouver, ISO, and other styles

27

Goodrich, Jaclyn M., Miriam M. Calkins, Alberto J. Caban-Martinez, et al. "Per- and polyfluoroalkyl substances, epigenetic age and DNA methylation: a cross-sectional study of firefighters." Epigenomics 13, no. 20 (2021): 1619–36. http://dx.doi.org/10.2217/epi-2021-0225.

Full text

Abstract:

Background: Per- and polyfluoroalkyl substances (PFASs) are persistent chemicals that firefighters encounter. Epigenetic modifications, including DNA methylation, could serve as PFASs toxicity biomarkers. Methods: With a sample size of 197 firefighters, we quantified the serum concentrations of nine PFASs, blood leukocyte DNA methylation and epigenetic age indicators via the EPIC array. We examined the associations between PFASs with epigenetic age, site- and region-specific DNA methylation, adjusting for confounders. Results: Perfluorohexane sulfonate, perfluorooctanoate (PFOA) and the sum of

APA, Harvard, Vancouver, ISO, and other styles

28

Ke, Mujing. "Identification and Validation of Apparent Imbalanced Epi-lncRNAs Prognostic Model Based on Multi-Omics Data in Pancreatic Cancer." Frontiers in Molecular Biosciences 9 (May 12, 2022). http://dx.doi.org/10.3389/fmolb.2022.860323.

Full text

Abstract:

Background: Globally, pancreatic adenocarcinoma is a recognized cause of pancreatic death (PAAD) associated with high mortality. Long non-coding RNAs (lncRNAs) play an important role in several biological processes in pancreatic cancer.Methods: The gene expression profile of PAAD patients were obtained from The Cancer Genome Atlas (TCGA) database. The limma package was used to identify epigenetic disorders of lncRNAs and PCG. Subsequently, the genomic characteristics and landscape of lncRNAs were explored. The pancreatic cancer-related lncRNAs gene set from Lnc2Cancer v3.0 were collected and t

APA, Harvard, Vancouver, ISO, and other styles

29

Turner, K. A., T. W. Radecki, E. L. Boughner, and K. D. Bolhuis. "B-183 The Impact of 3-EPI-25-Hydroxyvitamin D on 25-Hydroxyvitamin D Measurement by Liquid Chromatography/Mass Spectrometry." Clinical Chemistry 69, Supplement_1 (2023). http://dx.doi.org/10.1093/clinchem/hvad097.514.

Full text

Abstract:

Abstract Background 25-hydroxyvitamin D is the recommended target to evaluate vitamin D status. The accurate measurement of 25-hydroxyvitamin D by liquid chromatography/mass spectrometry (LC/MS/MS) is impacted by the presence of the biologically inactive epimer of 25-hydroxyvitamin D2 and D3, 3-EPI-25-hydroxyvitamin D2 and D3. The epimers are isomers and share the same mass and fragment transitions as 25-hydroxyvitamin D2 and D3. For an accurate measurement the epimer should be chromatographically separated from 25-hydroxyvitamin D. Herein we assess the significance of 3-EPI-25-hydroxyvitamin

APA, Harvard, Vancouver, ISO, and other styles

30

Sun, Chunzhao, Tsubasa Inokuma, Daisuke Tsuji, Yousuke Yamaoka, Reiko Akagi, and Ken-ichi Yamada. "Total Synthesis of 1,4a-di-epi-ent-Pancratistatin, Exemplifying a Stereodivergent Approach to Pancratistatin Isomers." Chemical Communications, 2024. http://dx.doi.org/10.1039/d4cc02199a.

Full text

Abstract:

The total synthesis of 1,4a-di-epi-ent-pancratistatin, a novel stereoisomer of the anti-tumor Amaryllidaceae alkaloid pancratistatin, was achieved in 14 steps starting from D-mannitol. The construction of the pancratistatin skeleton involved conjugate...

APA, Harvard, Vancouver, ISO, and other styles

31

Amir Hamzah, Khalisa, Leisa-Maree Toms, Nathaniel Kucharski, et al. "Age and sex effects of a validated LC-MS/MS method for the simultaneous quantification of testosterone, allopregnanolone, and its isomers in human serum." Scientific Reports 14, no. 1 (2024). http://dx.doi.org/10.1038/s41598-024-78807-3.

Full text

Abstract:

AbstractDespite the great relevance of the neurosteroid allopregnanolone and related isomers to various health conditions, quantification typically involves immunoassay, which suffers from serious issues with cross-reactivity of closely related molecules. This article describes the development and partial validation of a liquid chromatography coupled with tandem mass spectrometry assay for the simultaneous quantification of allopregnanolone, pregnanolone, isopregnanolone, epi-allopregnanolone, and testosterone in the human serum of healthy males and females aged 5–85 years. 1-amino-4-methylpip

APA, Harvard, Vancouver, ISO, and other styles

32

Egenolf, Konrad, Jochen Schöne, Jürgen Conrad, et al. "Root exudate fingerprint of Brachiaria humidicola reveals vanillin as a novel and effective nitrification inhibitor." Frontiers in Molecular Biosciences 10 (December 5, 2023). http://dx.doi.org/10.3389/fmolb.2023.1192043.

Full text

Abstract:

Introduction: Biological Nitrification Inhibition (BNI) is defined as the plant-mediated control of soil nitrification via the release of nitrification inhibitors. BNI of Brachiaria humidicola (syn. Urochloa humidicola) has been mainly attributed to root-exuded fusicoccane-type diterpenes, e.g., 3-epi-brachialactone. We hypothesized, however, that BNI of B. humidicola is caused by an assemblage of bioactive secondary metabolites.Methods:B. humidicola root exudates were collected hydroponically, and metabolites were isolated by semi-preparative HPLC. Chemical structures were elucidated by HRMS

APA, Harvard, Vancouver, ISO, and other styles

33

Flachsmann, Felix, Natalie Aeberli, Sandro Dossenbach, et al. "Ambrox through the Looking Glass: Chemoenzymatic Synthesis and GC‐Olfactometric Analysis of 15 Ambrox Stereoisomers." Helvetica Chimica Acta, May 8, 2024. http://dx.doi.org/10.1002/hlca.202400016.

Full text

Abstract:

All eight theoretical stereoisomers of 10S‐Ambrox have been synthesized by enzymatic polycyclization of the four geometric isomers of homofarnesol with selected squalene hopene cyclases. This includes the highly strained (+)‐(8S,9S)‐Ambrox, an isomer historically considered unlikely to exist. The enantiomeric 10R‐series has been prepared by a combination of diastereoselective synthesis and preparative chiral HPLC. Thus, for the first time, the synthesis and sensory properties of all but one stereoisomers of Ambrox are presented. The results solve a long standing peradventure: the commercial pr

APA, Harvard, Vancouver, ISO, and other styles

34

Chadha, Sanya, N. Arjunreddy Mallampudi, Debendra K. Mohapatra, and Rentala Madhubala. "Genetic Validation of Leishmania donovani Lysyl-tRNA Synthetase Shows that It Is Indispensable for Parasite Growth and Infectivity." mSphere 2, no. 4 (2017). http://dx.doi.org/10.1128/mspheredirect.00340-17.

Full text

Abstract:

ABSTRACT Leishmania donovani is a protozoan parasite that causes visceral leishmaniasis. Increasing resistance and severe side effects of existing drugs have led to the need to identify new chemotherapeutic targets. Aminoacyl-tRNA synthetases (aaRSs) are ubiquitous and are required for protein synthesis. aaRSs are known drug targets for bacterial and fungal pathogens. Here, we have characterized and evaluated the essentiality of L. donovani lysyl-tRNA synthetase (LdLysRS). Two different coding sequences for lysyl-tRNA synthetases are annotated in the Leishmania genome database. LdLysRS-1 (LdBP

APA, Harvard, Vancouver, ISO, and other styles

35

Singh, Sadhana, Varsha Kothari, Anupama Gupta, Puneet Panwar, Sonal Mishra, and Pavan Gaurav. "Effect of Isobaric Levobupivacaine and Fentanyl versus Isobaric Ropivacaine and Fentanyl as an Adjuvant in Patients Undergoing Transurethral Resection of the Prostate: A Randomised Clinical Study." JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2023. http://dx.doi.org/10.7860/jcdr/2023/64666.18748.

Full text

Abstract:

Introduction: Ropivacaine is a newer local anaesthetic proven to have a lower systemic toxicity profile, particularly in terms of cardiac and Central Nervous System (CNS) toxicity, than the racemic and levorotatory isomers of bupivacaine, especially in elderly patients. Fentanyl, as an adjuvant, enhances analgesia and promotes early postoperative mobility. Aim: To assess and compare the efficacy and safety of isobaric levobupivacaine and fentanyl versus isobaric ropivacaine and fentanyl in patients undergoing Transurethral Resection of the Prostate (TURP) under Spinal Anaesthesia (SA). Materia

APA, Harvard, Vancouver, ISO, and other styles

36

Yoon, Hyung-Suk, Jie Wu, Chris Shidal, et al. "Associations between Plasma Tocopherols and Lung Cancer Risk: Results from the Southern Community Cohort Study." Cancer Epidemiology, Biomarkers & Prevention, January 29, 2024. http://dx.doi.org/10.1158/1055-9965.epi-23-1107.

Full text

Abstract:

Abstract Background: Despite the various anticancer activities of tocopherols, little is known about tocopherols associated with lung cancer risk among low-income African Americans (AAs) and European Americans (EAs) who are disproportionately affected by the disease. Methods: We conducted a nested case-control study that included 209 incident lung cancer cases and 406 matched controls within the Southern Community Cohort Study. Using biospecimens collected at cohort enrollment, plasma levels of α-, β/γ-, δ-, and total-tocopherols were measured by high-performance liquid chromatography with pho

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!