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Dissertations / Theses on the topic 'Epidermal hair'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Whitehouse, Claire Jenna. "Hair follicle germinative epidermal cells : a molecular study." Thesis, Durham University, 1999. http://etheses.dur.ac.uk/4292/.

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At the base of the hair follicle epidermal matrix is a population of germinative epidermal (GE) cells that is in close communication with the dermal papilla. These GE cells are at the core of activities that comprise the fundamental processes of cell signalling and differentiation in the hair follicle. Since it is in the germinative region that the signals that produce hair are being received and transcribed, identification of genes expressed in the GE cells will be important for our understanding of hair growth control and the molecular mechanisms operating at the site of epidermal proliferat

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2

Asamaowei, Inemo E. "The Role of Polycomb Repressive Complex 2 in Epidermal Homeostasis and Hair Growth." Thesis, University of Bradford, 2017. http://hdl.handle.net/10454/16844.

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Polycomb repressive complex 2 (PRC2) catalyses the methylation of ‘Lys-27’ of histone H3, leading to transcriptional repression of target genes through its catalytic subunit Enhancer of zeste homolog 1/2 (EZH1/2). PRC2 functions as a critical regulator of stem cells in mouse embryonic and adult tissues. However, the role of PRC2 in human skin remains largely unknown. This study investigated the role of PRC2 in human epidermal homeostasis and hair growth. The expression of EZH2 was elevated in differentiating suprabasal layers of the human epidermis. Consistently, EZH1/2 expression and enzymat

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3

Foreman, Julia Louise. "Genetic and molecular analysis of root hair initiation and tip growth in Arabidopsis thaliana." Thesis, University of East Anglia, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247111.

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4

Duhéron, Vincent. "Hair and epidermal renewal by the receptor activator of NF-kappaB." Strasbourg, 2009. http://www.theses.fr/2009STRA6154.

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5

Mak, King-lun Kingston. "A transgenic mouse model to study the role of epidermal growth factor (EGF) in hair and skin development." Click to view the E-thesis via HKUTO, 2002. http://sunzi.lib.hku.hk/hkuto/record/B42576787.

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6

Davidson, Bruce Paul, University of Western Sydney, and School of Biological Sciences. "Compound mutations in the mammalian EGFR signalling pathway affect epidermal development, growth and viability." THESIS_XXXX_SBS_Davidson_B.xml, 1997. http://handle.uws.edu.au:8081/1959.7/518.

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The widespread expression of polypeptide growth factors from the earliest stages of embryonic development through to mature issues in the adult organism suggests an involvement in a reiterated developmental process affecting the underlying cellular growth and differentiation of many tissues. The hair follicle has taken on increased significance with the observation that many genetic mutations in these peptide growth factor genes affect its development. The targeted disruption of genes encoding members of the EpidermalGrowth Factor (EGF) and Fibroblast Growth Factor (FGF) families in the mouse

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7

Yang, Chia-Ling. "Studies on the metabolism, ageing and response to epidermal growth factor of hair follicles." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620083.

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8

Barnbrook, Matthew David. "The gene(s) responsible for variation in epidermal hair (trichome) distribution amongst Antirrhinum species." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/29565.

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Trichomes are hair-like structures found on the surface of virtually all terrestrial plants (Yang et al., 2015). They are epidermal outgrowths that can occur on all of the aerial parts of a plant, varying markedly in size, shape, distribution, and in their ability to produce secondary metabolites. About 30% of all vascular plants carry the glandular trichomes capable of producing secondary metabolites (Glas et al., 2012). Trichomes are vitally important to plants as a defence mechanism, they are highly significant commercially, and they are of interest to plant biologists in that they serve as

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9

麥經綸 and King-lun Kingston Mak. "A transgenic mouse model to study the role of epidermal growthfactor (EGF) in hair and skin development." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B42576787.

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10

Rahbar, Ramtin. "Claudin tight junctionwhat's your function? The role of Claudin 6 in epidermal and hair follicle differentiation." Thesis, University of Ottawa (Canada), 2004. http://hdl.handle.net/10393/26751.

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To elucidate the role of Claudin 6, a member of a new super family of TJ molecules, in the skin, we overexpressed it using the promoter for the differentiation marker, involucrin (Carrot et. al. 1993). Homozygous INV-Claudin 6 animals exhibit epidermal differentiation aberrations that result in incomplete formation of EPB and neonatal death (Turksen and Troy 2002). Heterozygote animals have milder EPB defects and survive to adulthood. All heterozygotes have pronounced abnormalities in their coat characterized by fuzzy hairs and a matte texture. In agreement with our hypothesis, the anagen phas

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11

Gharzi, Ahmad. "Dermal and epidermal cell functions in the growth and regeneration of hair follicles and other skin appendages." Thesis, Durham University, 1998. http://etheses.dur.ac.uk/4659/.

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Epithelial-mesenchymal interactions are central to the development of skin and skin appendages in vertebrates. These interactions continue throughout adult life and underpin the cyclic growth and loss of hair in mammals. While the molecular basis of such interactions are being gradually uncovered, at the cellular level many questions remain unanswered. For example, the localisation and role of hair follicle epithelial stem cells remains a subject of debate, as does the function of the dermal sheath component. In embryonic appendage development there is strong evidence for common signalling mec

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12

Davidson, Bruce Paul. "Compound mutations in the mammalian EGFR signalling pathway affect epidermal development, growth and viability /." View thesis, 1997. http://library.uws.edu.au/adt-NUWS/public/adt-NUWS20030826.115144/index.html.

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13

Petersson, Monika [Verfasser], Jens [Akademischer Betreuer] Brüning, and Thomas [Akademischer Betreuer] Krieg. "Characterisation of hair follicle stem cell function in epidermal regeneration and tumourigenesis / Monika Petersson. Gutachter: Jens Brüning ; Thomas Krieg." Köln : Universitäts- und Stadtbibliothek Köln, 2011. http://d-nb.info/1038111307/34.

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14

Robertson, Jennifer Vivian. "Distribution of the epidermal growth factor receptor during the initial hair cycle of C57-BL/6J-A§w§-§j and downy mice." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ35927.pdf.

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15

Poterlowicz, Krzysztof. "An integrative bioinformatics approach for analyses of multi-level transcriptional regulation and three-dimensional organization in the epidermis and skin appendages : exploring genomic transcriptional profiles of the distinct stages of hair follicle and sweat gland development and analyses of mechanism integrating the transcriptional regulation, linear and high-order genome organization within epidermal differentiation complex in keratinocytes." Thesis, University of Bradford, 2013. http://hdl.handle.net/10454/5658.

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The transcription in the eukaryotic cells involves epigenetic regulatory mechanisms that control local and higher-order chromatin remodelling. In the skin, keratinocyte-specific genes are organized into distinct loci including Epidermal Differentiation Complex (EDC) and Keratin type I/II loci. This thesis introduces bioinformatics approaches to analyze multi-level regulatory mechanisms that control skin development and keratinocyte-specific differentiation. Firstly, integration of gene expression data with analyses of linear genome organization showed dramatic downregulation of the genes that

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16

Tan, Ying. "Trichome morphology and development in the genus Antirrhinum." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/33235.

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The distribution of epidermal hairs (trichomes) is an important taxonomic character in the genus Antirrhinum. Most species in subsection Antirrhinum produce trichomes from lower internodes and leaves, then have bald stems and leaf blades after the third node and resume trichomes production again in the inflorescence (the "bald" phenotype). All species in subsection Kickxiella produce trichomes throughout development (the "hairy" phenotype). Populations of some species are polymorphic for trichome distribution-both bald and hairy individuals were observed in A. australe, A. graniticum, A. latif

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17

Yamamoto, Norio. "Notch/RBP-J Signaling Regulates Epidermis/Hair Fate Determination of Hair Follicular Stem Cells." Kyoto University, 2004. http://hdl.handle.net/2433/147463.

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18

Jorge, Aline Roberta Campos Donati. "Caracterização clínica e laboratorial do acometimento dos folículos velos e da epiderme da face, pescoço e região anterossuperior do tórax na alopecia frontal fibrosante." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5133/tde-05122018-123917/.

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INTRODUÇÃO: A alopecia frontal fibrosante (AFF) é uma alopecia cicatricial primária linfocítica descrita em 1994, cuja prevalência vem aumentando rapidamente em todo mundo. A participação de um fator desencadeante ambiental na patogênese da doença é aventada e uma pesquisa recente encontrou uma associação da doença com o uso de cosméticos faciais. Alterações da pele e dos pelos da face e do corpo têm sido descritas em pacientes com AFF nos últimos anos e alguns estudos sugerem que essas alterações possam preceder a perda dos cabelos, indicando o início da doença fora do couro cabeludo. OBJETIV

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19

Chrostek-Grashoff, Anna Magdalena. "The Role of Rac1 in the Epidermis and in the Hair Follicle." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-68133.

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20

Bruce, Gareth. "Characterisation of epidermal primary afferents innervating the hairy skin in a THY1.2-EGFP transgenic mouse." Thesis, University of Liverpool, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526788.

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21

Matos, Catarina Fernandes Marques de. "Histofisiologia das glândulas sudoríparas em vacas leiteiras face à aclimatação sazonal." Master's thesis, Universidade de Évora, 2015. http://hdl.handle.net/10174/17659.

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O presente estudo teve como objetivos, caracterizar a pele e anexos de vacas Holstein Frísia em lactação e avaliar eventuais alterações face à aclimatação sazonal. Foram realizados dois períodos de ensaio, de Inverno e de Verão. Em cada período, com a duração de 5 dias, foram recolhidas diariamente, em 10 vacas, às 8, 13 e 18h: a frequência respiratória, a temperatura retal e a taxa de sudação. Os dados meteorológicos foram obtidos antes de cada medição, através da aferição direta dos termómetros de Globo Negro no local das recolhas, localizados ao sol e à sombra. Em cada um dos períodos foram

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22

Hirano, Zelinda Maria Braga. "Secreção epidérmica de Alouatta guariba clamitans (Primates: Atelidae)." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/59/59139/tde-26042012-090335/.

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Primatas da subespécie A. g. clamitans, popular bugio, possuem um dimorfismo sexual evidenciado na fase adulta com machos de cor ruiva e fêmeas de cor castanho com nuanças avermelhadas. Em estudos de cativeiro com esta subespécie descobriu-se uma secreção epidérmica avermelhada, semelhante à cor da pelagem dos MA. A partir desta constatação diferentes hipóteses têm sido levantadas sobre a função e a origem desta secreção. Assim, o presente estudo objetivou: 1- Analisar se esta secreção é responsável pela coloração do pêlo dos animais e se a água é capaz de descolorir os pêlos 2- Verificar se

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23

Seldin, Lindsey. "The Role of Spindle Orientation in Epidermal Development and Homeostasis." Diss., 2015. http://hdl.handle.net/10161/9835.

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<p>Robust regulation of spindle orientation is essential for driving asymmetric cell divisions (ACDs), which generate cellular diversity within a tissue. During the development of the multilayered mammalian epidermis, mitotic spindle orientation in the proliferative basal cells is crucial not only for dictating daughter cell fate but also for initiating stratification of the entire tissue. A conserved protein complex, including LGN, Nuclear mitotic apparatus (NuMA) and dynein/dynactin, plays a key role in establishing proper spindle orientation during ACDs. Two of these proteins, NuMA and dyne

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24

Brito, Joana Rita Fernandes Castilho de. "Evaluation of hair dyes influence on the epidermal barrier using an in vitro test." Master's thesis, 2017. http://hdl.handle.net/10451/36040.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2017<br>The human being has the intrinsic desire to improve his appearance. Therefore, hair dyes have become a very popular product, which knows no gender or age barriers. According to statistics, more than 70% of women in developed world admit dyeing their hair at least once in their lifetime and most do so on a regular basis. Due to the extensive use of this type of products and their high chemical complexity, safety and legislation are very important aspects to ensure high standards

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25

Kauser, Sobia, Gillian E. Westgate, M. R. Green, and Desmond J. Tobin. "Human Hair Follicle and Epidermal Melanocytes Exhibit Striking Differences in Their Aging Profile which Involves Catalase." 2011. http://hdl.handle.net/10454/7453.

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no<br>Canities or senile hair graying, a universally recognized sign of aging, remains unresolved in terms of physiological causes, although a strong genetic contribution is understood (Gunn et al., 2009). As the hair fiber continues to grow long after melanin production ceases, we suggest that melanocytes in the hair follicle may be more sensitive to the impact of chronological aging than are keratinocytes. Moreover, follicular melanocytes also age more markedly than those in the overlying epidermis. The hair follicle provides a unique opportunity to decouple the impact of age on two hair fol

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26

Davidson, Bruce P. "Compound mutations in the mammalian EGFR signalling pathway affect epidermal development, growth and viability." Thesis, 1997. http://handle.uws.edu.au:8081/1959.7/518.

Full text

Abstract:

The widespread expression of polypeptide growth factors from the earliest stages of embryonic development through to mature issues in the adult organism suggests an involvement in a reiterated developmental process affecting the underlying cellular growth and differentiation of many tissues. The hair follicle has taken on increased significance with the observation that many genetic mutations in these peptide growth factor genes affect its development. The targeted disruption of genes encoding members of the EpidermalGrowth Factor (EGF) and Fibroblast Growth Factor (FGF) families in the mouse

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27

Mardaryev, Andrei N., N. Meier, Krzysztof Poterlowicz, et al. "Lhx2 differentially regulates Sox9, Tcf4 and Lgr5 in hair follicle stem cells to promote epidermal regeneration after injury." 2011. http://hdl.handle.net/10454/6079.

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The Lhx2 transcription factor plays essential roles in morphogenesis and patterning of ectodermal derivatives as well as in controlling stem cell activity. Here, we show that during murine skin morphogenesis, Lhx2 is expressed in the hair follicle (HF) buds, whereas in postnatal telogen HFs Lhx2(+) cells reside in the stem cell-enriched epithelial compartments (bulge, secondary hair germ) and co-express selected stem cell markers (Sox9, Tcf4 and Lgr5). Remarkably, Lhx2(+) cells represent the vast majority of cells in the bulge and secondary hair germ that proliferate in response to skin injury

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28

Chrostek-Grashoff, Anna Magdalena [Verfasser]. "The role of Rac1 in the epidermis and in the hair follicle / vorgelegt von Anna Magdalena Chrostek-Grashoff." 2007. http://d-nb.info/984634843/34.

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29

Lyubimova, A., J. J. Garber, G. Upadhyay, et al. "Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in mice." 2010. http://hdl.handle.net/10454/6073.

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The Rho family GTPases Cdc42 and Rac1 are critical regulators of the actin cytoskeleton and are essential for skin and hair function. Wiskott-Aldrich syndrome family proteins act downstream of these GTPases, controlling actin assembly and cytoskeletal reorganization, but their role in epithelial cells has not been characterized in vivo. Here, we used a conditional knockout approach to assess the role of neural Wiskott-Aldrich syndrome protein (N-WASP), the ubiquitously expressed Wiskott-Aldrich syndrome-like (WASL) protein, in mouse skin. We found that N-WASP deficiency in mouse skin led to se

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