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Dissertations / Theses on the topic 'Erythrocyte (human)'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Gonzalez, Laurie J. "The influence of membrane lipid order on cell shape and microvesiculation in human erythrocytes /." Diss., CLICK HERE for online access, 2006. http://contentdm.lib.byu.edu/ETD/image/etd1615.pdf.

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2

Flatt, Joanna Frances. "A study of human erythrocyte membrane structure and function using variant erythrocytes." Thesis, University of Bristol, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.560498.

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Human erythrocytes are highly specialised cells boasting numerous features to maximise gas carriage, exchange and delivery around the body. The role of the highly proteinaceous red cell membrane in these processes is vital. Some membrane proteins such as the Rh-associated glycoprotein (RhAG) and aquaporin-1 (AQP1) are postulated to form gas channels, and disorders affecting membrane proteins can have extensive effects on normal red cell function. In this work, the role and interactions of Rh proteins are probed using rare variant Rh-deficient erythrocytes. The RhCE polypeptide is required for

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3

Darmani, Homa. "Erythrocyte adhesion by macromolecules." Thesis, Cardiff University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278681.

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4

Boey, Seng Kee. "Computer simulation of the human erythrocyte cytoskeleton." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq24296.pdf.

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5

Sommerville, W. "An evaluation of human erythrocyte sulphydryl groups." Thesis, University of Strathclyde, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382552.

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6

Morrow, Robert Peter. "A study into human erythrocyte membrane protein association." Thesis, University of Bristol, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288406.

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7

Bruce, Lesley J. "A study of human erythrocyte band 3 variants." Thesis, University of Bristol, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240590.

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8

Kharalkar, Shilpa S. "Identification of Novel Allosteric Regulators of Human Erythrocyte Pyruvate Kinase." VCU Scholars Compass, 2006. http://hdl.handle.net/10156/2083.

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9

Taylor, Andrew Mark. "Biophysical studies on the human erythrocyte anion transporter, band 3." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360571.

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10

Graybill, Christopher A. "Biophysical Analysis of the Human Erythrocyte Glucose Transporter: a Dissertation." eScholarship@UMMS, 2005. https://escholarship.umassmed.edu/gsbs_diss/207.

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Hydrodynamic analysis and electron microscopy of GLUT1/lipid/detergent micelles and freeze fracture electron microscopy of GLUT1 proteoliposomes support the hypothesis that the glucose transporter is a multimeric (probably tetrameric) complex of GLUT1 proteins. Some detergents (e.g. octylglucoside) maintain the multimeric complex while other detergents (e.g. CHAPS and dodecylmaltoside) promote the dissociation of GLUT1 oligomers into smaller aggregation states (dimers or monomers). GLUT1 does not appear to exchange rapidly between protein/lipid/detergent micelles but is able to self-associate

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11

Graybill, Christopher A. "Biophysical Analysis of the Human Erythrocyte Glucose Transporter: a Dissertation." eScholarship@UMMS, 2010. http://escholarship.umassmed.edu/gsbs_diss/207.

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Hydrodynamic analysis and electron microscopy of GLUT1/lipid/detergent micelles and freeze fracture electron microscopy of GLUT1 proteoliposomes support the hypothesis that the glucose transporter is a multimeric (probably tetrameric) complex of GLUT1 proteins. Some detergents (e.g. octylglucoside) maintain the multimeric complex while other detergents (e.g. CHAPS and dodecylmaltoside) promote the dissociation of GLUT1 oligomers into smaller aggregation states (dimers or monomers). GLUT1 does not appear to exchange rapidly between protein/lipid/detergent micelles but is able to self-associate

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12

Holme, E. R. "C3b receptors (CR1) on peripheral human blood cells." Thesis, University of Glasgow, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381473.

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13

Storry, Jill Rosalind. "A study of the expression of human erythrocyte glycophorin B variants." Thesis, University of the West of England, Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322431.

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14

Blodgett, David M. "Human Erythrocyte Glucose Transporter (GLUT1) Structure, Function, and Regulation: A Dissertation." eScholarship@UMMS, 2007. https://escholarship.umassmed.edu/gsbs_diss/326.

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The structure-function relationship explains how the human erythrocyte glucose transport protein (GLUT1) catalyzes sugar transport across the plasma membrane. This work investigates the glucose transport mechanism, the structural arrangement and dynamics of GLUT1 membrane-spanning α-helices, the molecular basis for glucose transport regulation by ATP, and how cysteine accessibility contributes to GLUT1 structure. A rapid kinetics approach was applied to examine the conformational changes GLUT1 undergoes during the transport cycle. To transition from a global to molecular focus, a novel mass sp

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15

Chapman, Bogdan E., and Philip W. Kuchel. "Diffusion-Ordered (DOSY) NMR of solute exchange across the human erythrocyte membrane." Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-194446.

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Nuclear magnetic resonance (NMR) spectroscopy was used to study exchange of three distinctly different molecules across the membranes of human red blood cells (RBCs). In studying water, t-butanol, and dimethyl sulfoxide we exploited the marked differences in the apparent diffusion coefficients of these species inside and outside the cells in suspensions. The measurements were made with diffusion ordered spectroscopy (DOSY) with a domain of ‘diffusion times’ of 20 - 100 ms. In attempting to make the DOSY spectra quantitative we identified time domains for each of the three molecules in which th

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16

Thomas, James A. "A protease cascade regulates egress of Plasmodium falciparum from the human erythrocyte." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10045224/.

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Malaria parasites invade erythrocytes and replicate inside a parasitophorous vacuole (PV). Invasive merozoites eventually egress in a process that involves sequential rupture of first the PV membrane (PVM) then the erythrocyte membrane. Egress is protease-dependent, with both cysteine and serine proteases implicated. The parasite serine protease SUB1 is stored in merozoite secretory organelles that are discharged into the PV 10 minutes before erythrocyte membrane rupture. Pharmacological inhibition of SUB1 activity or discharge blocks egress, but the mechanism by which SUB1 regulates egress is

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17

D'Avila, F. "Identification and characterization of the acidic sialidase present on human erythrocyte membranes." Doctoral thesis, Università degli Studi di Milano, 2008. http://hdl.handle.net/2434/49651.

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Sialidases or neuraminidases (EC 3.2.1.18) are enzymes widely distributed in nature, from viruses to vertebrates. They play a key role in the metabolism of sialoglycoconjugates. In particular, they are able to remove sialic acid residues from gangliosides, sialoglycoproteins and sialoligosaccharides. It is becoming more and more evident that the partial desialylation of senescent erythrocyte membrane sialoglycoconjugates is a primary or preliminary signal for erythrophagocytosis. The removal of sialic acid from the sialoglycoconjugates is assumed to be promoted by the sialidases present on the

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18

Burlak, Christopher II. "Analysis of Porcine Kupffer Cell Recognition of Human Erythrocytes." University of Toledo Health Science Campus / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=mco1083268448.

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19

Lloyd, Kenneth P. "Understanding Human Erythrocyte Glucose Transporter (GLUT1) Mediated Glucose Transport Phenomena Through Structural Analysis." eScholarship@UMMS, 2018. https://escholarship.umassmed.edu/gsbs_diss/962.

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GLUT1-mediated, facilitated sugar transport is proposed to be an example of transport by a carrier that alternately presents exofacial (e2) and endofacial (e1) substrate binding sites, commonly referred to as the alternating access carrier model. This hypothesis is incompatible with observations of co-existent exo- and endofacial ligand binding sites, transport allostery, and e1 ligand (e.g. cytochalasin B) induced GLUT1 sugar occlusion. The fixed-site carrier model proposes co-existent, interacting e2 and e1 ligand binding sites but involves sugar translocation by geminate exchange through in

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20

Moniwa, Mariko. "Characterization of the human HDAC1, HDAC2, HDAC3, and chicken erythrocyte histone deacetylase activities." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0018/MQ53197.pdf.

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21

Ridgwell, K. "A study of some protein blood group antigens of the human erythrocyte membrane." Thesis, University of Bristol, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375406.

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22

Wang, Lin. "Complementation and membrane assembly studies of human erythrocyte anion exchanger (AE1, band 3)." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388102.

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23

Young, Mark. "Studies of the transmembrane domain of the human erythrocyte anion exchanger (band 3)." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340324.

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24

Levine, Kara B. "Identification of the Human Erythrocyte Glucose Transporter (GLUT1) ATP Binding Domain: A Dissertation." eScholarship@UMMS, 1999. https://escholarship.umassmed.edu/gsbs_diss/247.

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The human erythrocyte glucose transport protein (GLUT1) interacts with, and is regulated by, cytosolic ATP. This study asks the following questions concerning ATP modulation of GLUT1 mediated sugar transport. 1) Which region(s) of GLUT1 form the adenine nucleotide-binding domain? 2) What factors influence ATP modulation of sugar transport? 3) Is ATP interaction with GLUT1 sufficient for sugar transport regulation? The first question was addressed through peptide mapping, n-terminal sequencing, and alanine scanning mutagenesis of GLUT1 using [32P]-azidoATP, a photoactivatable ATP analog. We the

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25

Crick, Alex James. "Live imaging studies of the interactions of the malaria parasite with the human erythrocyte." Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708165.

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26

Wang, Kevin Ka-Wang. "Studies on the proteolysis of the human erythrocyte calcium-pumping ATPase by endogenous calpain." Thesis, University of British Columbia, 1989. http://hdl.handle.net/2429/29314.

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It is well known that the erythrocyte plasma membrane Ca²⁺-pumping ATPase can be activated by calmodulin. Limited proteolysis of the Ca²⁺-ATPase with exogenous proteases can also produce a calmodulin-like activation. Because a calcium-dependent cysteine protease (calpain I) is present in the erythrocyte cytosol, it was proposed that this enzyme could proteolytically activate the Ca²⁺-ATPase during a sustained elevation of the cytosolic free Ca²⁺ level. Upon incubation of red blood cell membranes with purified calpain I and Ca²⁺, the membrane-bound Ca²⁺-ATPase activity was increased and its se

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27

Meenaghan, Michael. "Human erythrocyte membrane UDPgal:GalNAc #beta#1,3 D-galactosyltransferase activity in individuals with Tn syndrome." Thesis, University of the West of England, Bristol, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236252.

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28

Parsons, Stephen Frederick. "The use of monoclonal antibodies to study the components of the human erythrocyte membrane." Thesis, Open University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278501.

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29

Tate, Christopher G. "cDNA cloning of human erythrocyte membrane proteins and studies of abnormal blood group phenotypes." Thesis, University of Bristol, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327929.

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30

Alghamdi, Sultan Ahmed. "Genetic determinants of selectivity of erythrocyte invasion in the human malaria parasite Plasmodium falciparum." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/6605/.

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The aim of this study was to investigate the genetic basis of selectivity in invasion of the red blood cells by the human malaria parasite Plasmodium falciparum. Multiple invasions of a single host red blood cell by more than one merozoite, which can be described or assessed in terms of the selectivity index (SI), has been reported to be related to the severity of malaria disease. In this study, selectivity index, defined as the ratio of the number of multiply-infected red cells observed to that expected from random invasion, as modelled by a Poisson distribution was determined for certain clo

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31

Waldman, Joshua. "Mechanisms of Human Erythrocyte Clearance During Human-to-Porcine-Liver Xenoperfusion and the Assessment of Current Pre-clinical Models." University of Toledo Health Science Campus / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=mco1378745834.

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32

Jones, Graham K. "Expression and anion transport studies on the human erythrocyte anion exchange protein (AE1, band 3)." Thesis, University of Bristol, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245676.

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33

Nokhostin, Kamaloddin Hamidi. "Human erythrocyte peroxire doxin II and its interaction with thioredoxin, sulfiredoxin and mitogen activated protein kinase." Thesis, University of Exeter, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.504638.

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34

Stauffer, Kathrin. "On the structure and function of membrane-integrated segments of the human erythrocyte band 3 protein /." [S.l : s.n.], 1986. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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35

Chaleckis, Romanas. "Fission yeast and human blood metabolomic comparison with focus on age related compounds." 京都大学 (Kyoto University), 2014. http://hdl.handle.net/2433/192226.

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36

Wang, Kai Ling. "Identification and characterisation of a Ras-related GTP-binding protein, Tal-A, purified from human erythrocyte membranes." Thesis, The University of Sydney, 1997. https://hdl.handle.net/2123/29249.

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This thesis investigates the identification and characterisation of a protein with monomeric molecular mass of 28 kDa (referred as to p28) purified from human erythrocyte plasma membrane. Chapter Two describes the purification of p28 from Triton X-100 extracts of human erythrocyte membrane by calmodulin affinity chromatography. Based on internal peptide sequencing and its protein amino acid composition, this protein has been shown to be highly related, if not identical to Ral-A, a Ras-related GTP-binding protein. Results presented in Chapter Three characterises this protein as a low-molecu

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37

Siano, James P. "Mechanism of plasmodium falciparum infected erythrocyte adherence to human dermal microvascular endothelial cells under physiologic flows conditions." Thesis, Georgia Institute of Technology, 1994. http://hdl.handle.net/1853/10153.

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38

Mills-Davies, Nicola Louise. "Structure of human erythrocyte 5-aminolaevulinic acid dehydratase, the second enzyme in the biosynthesis pathway of haem." Thesis, University of Southampton, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341613.

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39

Gonzalez, Laurie Jackson. "The Influence of Membrane Lipid Order on Cell Shape and Microvesiculation in Human Erythrocytes." BYU ScholarsArchive, 2006. https://scholarsarchive.byu.edu/etd/1058.

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Exposure of human erythrocytes to elevated intracellular calcium causes alterations in cell shape and stimulates shedding of the cell membrane in the form of microvesicles. We hypothesized that both the shape transition and microvesiculation are influenced by microscopic membrane physical properties such as lipid order. To test this hypothesis, membrane properties were manipulated by varying the experimental temperature, membrane cholesterol content, and the internal ionic environment. Changes in membrane order were assessed using steady-state fluorescence spectroscopy with an environment-sens

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40

Ghouma, S. M. "An investigation of the function of human IgM and IgG antibodies recognizing P. falciparum erythrocyte membrane protein 1 (PfEMP1)." Thesis, University of Liverpool, 2018. http://livrepository.liverpool.ac.uk/3022830/.

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41

Emami, Seyedeh Noushin. "The impact of erythrocyte density on the fitness of Anopheles gambiae mosquitoes and their capacity to transmit human malaria." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3724/.

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Anaemia is a common health problem affecting women and children in the developing world. This condition is characterized by a reduction in erythrocyte density, primarily resulting from malnutrition and/or infectious diseases such as malaria. As red blood cells are the most important source of protein for haematophagous mosquitoes, any reduction could impede the ability of mosquito vectors to transmit malaria by influencing their fitness and/or that of the parasites they transmit. The aim of this study was to determine the impact of differences in the density of red blood cells in human blood o

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42

Parker, Mark D. "Expression and anion transport studies on the human erythrocyte anion exchange protein (AE1, band 3) in the yeast Saccharomyces cerevisiae." Thesis, University of Bristol, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310589.

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43

Chapman, Bogdan E., and Philip W. Kuchel. "Diffusion-Ordered (DOSY) NMR of solute exchange across the human erythrocyte membrane: including an application of Post-Widder Laplace inversion." Diffusion fundamentals 4 (2007) 8, S. 1-15, 2007. https://ul.qucosa.de/id/qucosa%3A13230.

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Nuclear magnetic resonance (NMR) spectroscopy was used to study exchange of three distinctly different molecules across the membranes of human red blood cells (RBCs). In studying water, t-butanol, and dimethyl sulfoxide we exploited the marked differences in the apparent diffusion coefficients of these species inside and outside the cells in suspensions. The measurements were made with diffusion ordered spectroscopy (DOSY) with a domain of ‘diffusion times’ of 20 - 100 ms. In attempting to make the DOSY spectra quantitative we identified time domains for each of the three molecules in which th

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44

Montineri-Berling, Christine. "Proprietes rheologiques de melanges de populations d'erythrocytes en suspension dans leur plasma : application a la conservation du sang et a la transfusion." Paris 7, 1987. http://www.theses.fr/1987PA077137.

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45

Dalby, Amanda Louise. "Forward programming of human pluripotent stem cells to a megakaryocyte-erythrocyte bi-potent progenitor population : an in vitro system for the production of platelets and red blood cells for transfusion medicine." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/273749.

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There exists a need to produce platelets in vitro for use in transfusion medicine, due to increased platelet demands and short shelf life. Our lab uses human induced pluripotent stem cells (iPSCs), as an attractive alternative supply, as iPSCs can be cultured indefinitely and differentiate into almost any cell type. Using a technique called forward programming, we over express three key haematological transcription factors (TFs), pushing iPSCs towards the megakaryocyte lineage, to produce mature megakaryocytes, the platelet precursor cell type. A major limitation of the forward programming tec

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46

Janzen, Johan. "Fibrinogen adsorption to human erythrocytes." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/25820.

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Fibrinogen adsorption to human erythrocytes has been implicated as the mechanism responsible for the reversible aggregation of red cells. The object of this thesis was to measure the binding of fibrinogen to human erythrocytes and to compare the binding with aggregation behaviour. The binding of isolated ¹²⁵I-fibrinogen to red cells was estimated from the amount of radiolabel removed from solution upon addition of cells, from the amount of radiolabel retained in cell pellets produced by ultracentrifugation and corrected for intracellular radiolabel, and from radiolabel retained by cells af

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47

Staines, Henry Michael. "Cation transport in Plasmodium falciparum-infected human erythrocytes." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298726.

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48

Shapiro, Vladimir Michael. "GOLD UPTAKE BY DICYANOGOLD(I) TREATED HUMAN ERYTHROCYTES." University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin998307802.

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49

Bütikofer, Peter. "Membrane vesiculation of normal and pathologic human erythrocytes /." [S.l : s.n.], 1987. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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50

Dorval, Brent Leonard. "Human Erythrocytes inhibit complement-mediated solubilization on immune complexes by human serum /." The Ohio State University, 1987. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487326511716122.

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