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Journal articles on the topic 'Erythrocyte (human)'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Hsiao, L. L., R. J. Howard, M. Aikawa, and T. F. Taraschi. "Modification of host cell membrane lipid composition by the intra-erythrocytic human malaria parasite Plasmodium falciparum." Biochemical Journal 274, no. 1 (1991): 121–32. http://dx.doi.org/10.1042/bj2740121.

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The phospholipid and fatty acid compositions of the host infected erythrocyte plasma membrane (IEPM) have been determined for erythrocytes infected with the human malaria parasite Plasmodium falciparum. IEPM were prepared by selective lysis of the host erythrocyte (but not of the parasite membranes) with 0.1% saponin, followed by differential centrifugation. The purity of the IEPM was determined by measuring the membrane-specific enzyme markers acetylcholinesterase, glutamate dehydrogenase and lactate dehydrogenase, and by immunoelectron microscopy using monoclonal antibodies specific for huma

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2

Naparlo, Katarzyna, Grzegorz Bartosz, Ireneusz Stefaniuk, Bogumil Cieniek, Miroslaw Soszynski, and Izabela Sadowska-Bartosz. "Interaction of Catechins with Human Erythrocytes." Molecules 25, no. 6 (2020): 1456. http://dx.doi.org/10.3390/molecules25061456.

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The aim of this study was to characterize the interaction of chosen catechins ((+)-catechin, (−)-epigallocatechin (EGC), and (−)-epigallocatechin gallate (EGCG)) with human erythrocytes and their protective effects against oxidative damage of erythrocytes. Uptake of the catechins by erythrocytes was studied by fluorimetry, their interaction with erythrocyte membrane was probed by changes in erythrocyte osmotic fragility and in membrane fluidity evaluated with spin labels, while protection against oxidative damage was assessed by protection against hemolysis induced by permanganate and protecti

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3

Nardid, O., S. Repina, E. Bobrova, Yu Govorova, S. Narozhnyi, and E. Rozanova. "Beneficial impact of human placenta extracts on erythrocyte membrane thermostability." Trakia Journal of Sciences 16, no. 3 (2018): 204–11. http://dx.doi.org/10.15547/tjs.2018.03.006.

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PURPOSE: To study the influence of human placenta extract (HPE) and its individual fractions on the thermal stability of human erythrocyte membrane. METHODS: HPE fractions were isolated by gel chromatography. Thermal hemolysis of erythrocytes, exposed to 55°C was measured spectrophotometrically. Cytosol microvscosity and barrier function of erythrocyte membranes at hyperthermia were investigated by EPR spin probe TEMPON. Thermal denaturation of erythrocyte membrane proteins were studied by differential scanning calorimetry. RESULTS: Pre-treatment of erythrocytes with HPE or its fractions inhib

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4

Zhang, Dongyan, Junko Takahashi, Taiko Seno, Yoshihiko Tani, and Takeshi Honda. "Analysis of Receptor for Vibrio choleraeEl Tor Hemolysin with a Monoclonal Antibody That Recognizes Glycophorin B of Human Erythrocyte Membrane." Infection and Immunity 67, no. 10 (1999): 5332–37. http://dx.doi.org/10.1128/iai.67.10.5332-5337.1999.

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ABSTRACT El Tor hemolysin (ETH), a pore-forming toxin secreted byVibrio cholerae O1 biotype El Tor and most Vibrio cholerae non-O1 isolates, is able to lyse erythrocytes and other mammalian cells. To study the receptor for this toxin or the related molecule(s) on erythrocyte, we first isolated a monoclonal antibody, B1, against human erythrocyte membrane, which not only blocks the binding of ETH to human erythrocyte but also inhibits the hemolytic activity of ETH. Biochemical characterization and immunoblotting revealed that this antibody recognized an epitope on the extracellular domain of gl

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Duchnowicz, Piotr, Radosław Pilarski, Jaromir Michałowicz, and Bożena Bukowska. "Changes in Human Erythrocyte Membrane Exposed to Aqueous and Ethanolic Extracts from Uncaria tomentosa." Molecules 26, no. 11 (2021): 3189. http://dx.doi.org/10.3390/molecules26113189.

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Uncaria tomentosa (Willd.) DC is a woody climber species originating from South and Central America that has been used in the therapy of asthma, rheumatism, hypertension, and blood purification. Our previous study showed that U. tomentosa extracts altered human erythrocyte shape, which could be due to incorporation of the compounds contained in extracts into the erythrocyte membrane. The aim of the present study was to determine how the compounds contained in U. tomentosa extracts incorporate into the human erythrocyte membrane. The study has assessed the effect of aqueous and ethanolic extrac

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6

Klotz, F. W., J. D. Chulay, W. Daniel, and L. H. Miller. "Invasion of mouse erythrocytes by the human malaria parasite, Plasmodium falciparum." Journal of Experimental Medicine 165, no. 6 (1987): 1713–18. http://dx.doi.org/10.1084/jem.165.6.1713.

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Plasmodium falciparum malaria merozoites require erythrocyte sialic acid for optimal invasion of human erythrocytes. Since mouse erythrocytes have the form of sialic acid found on human erythrocytes (N-acetyl neuraminic acid), mouse erythrocytes were tested for invasion in vitro. The Camp and 7G8 strains of P. falciparum invaded mouse erythrocytes at 17-45% of the invasion rate of human erythrocytes. Newly invaded mouse erythrocytes morphologically resembled parasitized human erythrocytes as shown on Giemsa-stained blood films and by electron microscopy. The rim of parasitized mouse erythrocyt

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7

Nakagawa, Kiyotaka, Takehiro Kiko, Keijiro Hatade, Phumon Sookwong, Hiroyuki Arai, and Teruo Miyazawa. "Antioxidant effect of lutein towards phospholipid hydroperoxidation in human erythrocytes." British Journal of Nutrition 102, no. 9 (2009): 1280–84. http://dx.doi.org/10.1017/s0007114509990316.

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Peroxidised phospholipid-mediated cytotoxity is involved in the pathophysiology of many diseases; for example, phospholipid hydroperoxides (PLOOH) are abnormally increased in erythrocytes of dementia patients. Dietary carotenoids (especially xanthophylls, polar carotenoids such as lutein) have gained attention as potent inhibitors against erythrocyte phospholipid hydroperoxidation, thereby making them plausible candidates for preventing diseases (i.e. dementia). To evaluate these points, we investigated whether orally administered lutein is distributed to human erythrocytes, and inhibits eryth

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8

Orwa, Titus Okello, Rachel Waema Mbogo, and Livingstone Serwadda Luboobi. "Mathematical Model for Hepatocytic-Erythrocytic Dynamics of Malaria." International Journal of Mathematics and Mathematical Sciences 2018 (July 2, 2018): 1–18. http://dx.doi.org/10.1155/2018/7019868.

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Human malaria remains a major killer disease worldwide, with nearly half (3.2 billion) of the world’s population at risk of malaria infection. The infectious protozoan disease is endemic in tropical and subtropical regions, with an estimated 212 million new cases and 429,000 malaria-related deaths in 2015. An in-host mathematical model ofPlasmodium falciparummalaria that describes the dynamics and interactions of malaria parasites with the host’s liver cells (hepatocytic stage), the red blood cells (erythrocytic stage), and macrophages is reformulated. By a theoretical analysis, an in-host bas

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9

Brittain, HA, JR Eckman, RA Swerlick, RJ Howard, and TM Wick. "Thrombospondin from activated platelets promotes sickle erythrocyte adherence to human microvascular endothelium under physiologic flow: a potential role for platelet activation in sickle cell vaso-occlusion." Blood 81, no. 8 (1993): 2137–43. http://dx.doi.org/10.1182/blood.v81.8.2137.2137.

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Abstract Adherence of erythrocytes to vascular endothelium likely contributes to the pathophysiology of episodic vascular occlusion in patients with sickle cell disease (SCD). In addition, coagulation activation has been reported in sickle patients during complications such as pain episodes. To test the hypothesis that platelet activation contributes to sickle erythrocyte binding, we investigated whether factors released from activated sickle platelets promote adherence of sickle erythrocytes to human microvascular endothelial cells (MEC) under flow conditions. Activated sickle platelet supern

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Brittain, HA, JR Eckman, RA Swerlick, RJ Howard, and TM Wick. "Thrombospondin from activated platelets promotes sickle erythrocyte adherence to human microvascular endothelium under physiologic flow: a potential role for platelet activation in sickle cell vaso-occlusion." Blood 81, no. 8 (1993): 2137–43. http://dx.doi.org/10.1182/blood.v81.8.2137.bloodjournal8182137.

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Adherence of erythrocytes to vascular endothelium likely contributes to the pathophysiology of episodic vascular occlusion in patients with sickle cell disease (SCD). In addition, coagulation activation has been reported in sickle patients during complications such as pain episodes. To test the hypothesis that platelet activation contributes to sickle erythrocyte binding, we investigated whether factors released from activated sickle platelets promote adherence of sickle erythrocytes to human microvascular endothelial cells (MEC) under flow conditions. Activated sickle platelet supernatant (AS

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Luneva, Oksana G., Svetlana V. Sidorenko, Olga O. Ponomarchuk, et al. "Deoxygenation Affects Composition of Membrane-Bound Proteins in Human Erythrocytes." Cellular Physiology and Biochemistry 39, no. 1 (2016): 81–88. http://dx.doi.org/10.1159/000445607.

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Background/Aims: ATP release from erythrocyte plays a key role in hypoxia-induced elevation of blood flow in systematic circulation. We have previously shown that hemolysis contributes to erythrocyte ATP release triggered by several stimuli, including hypoxia, but the molecular mechanisms of hypoxia-increased membrane fragility remain unknown. Methods: In this study, we compared the action of hypoxia on hemolysis, ATP release and the composition of membrane-bound proteins in human erythrocytes. Results: Twenty minutes incubation of human erythrocytes in the oxygen-free environment increased th

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12

Stephan, Huber. "Editorial: Ion Channels of Mature Human Erythrocytes." Open Biology Journal 4, no. 1 (2011): 1–2. http://dx.doi.org/10.2174/18750362010040100001.

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Ion channels in the plasma membrane serve multiple functions such as setting the membrane potential, adjusting the cell volume and the intracellular electrolyte concentrations or eliciting versatile cytosolic Ca2+ signals. Channel activities regulate many basic cellular processes. Among those are cell proliferation, migration, differentiation and apoptotic cell death. Although devoid of nuclei and mitochondria, mature mammalian erythrocytes maintain a full set of functional ion channels in their plasma membrane. This special issue of The Open Biology Journal focuses on ion channels in the memb

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Sblano, Cesare, Silvia Micelli та Daniela Meleleo. "Effects of n-Octyl-β-D-Glucopyranoside on Human and Rat Erythrocyte Membrane Stability Against Hemolysis". Open Biology Journal 5, № 1 (2012): 1–5. http://dx.doi.org/10.2174/1874196701205010001.

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The practical importance for the pharmaceutical and cosmetics industries of the interactions between biological membranes and surfactant molecules has led to intensive research within this area. The interactions of non-ionic surfactant n-octyl-β-D-glucopyranoside (OG) with the human and rat erythrocyte membranes were studied. The in vitro hemolytic and antihemolytic activities were determined by employing a method in which both erythrocytes were added to the hypotonic medium containing OG at different concentrations, and the amount of haemoglobin released was determined. noctyl- β-D-glucopyran

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14

Lisovskaya, I. L., E. S. Shurkhina, E. E. Yakovenko, et al. "Distributions of rheological parameters in populations of human erythrocytes." Biorheology: The Official Journal of the International Society of Biorheology 36, no. 4 (1999): 299–309. http://dx.doi.org/10.1177/0006355x1999036004002.

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We have previously proposed the osmofiltration method based on a modified Hanss hemorheometer to analyze distributions of erythrocytes in their ability to pass through membrane filters with 3 $\mu$ m pores. Upon decrease in medium osmolality ( $u$ ) the erythrocyte volume increases. When cell volume becomes $V=V_{\mathrm{cr}}$ at $u=u_{\mathrm{cr}}$ , such cell loses its ability to pass through a 3 $\mu$ m pore. The flow rate of erythrocyte suspension containing cells with different $u_{\mathrm{cr}}$ through a filter gradually decreases with decreasing medium osmolality. This rate becomes zero

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15

Peterson, John W., Byung-Duk Kwun, Atsushi Teramura, et al. "Immunological reaction against the aging human subarachnoid erythrocyte." Journal of Neurosurgery 71, no. 5 (1989): 718–26. http://dx.doi.org/10.3171/jns.1989.71.5.0718.

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✓ The role of the aging human erythrocyte in the mechanisms leading to cerebral vasospasm after subarachnoid hemorrhage was investigated using an in vitro model for the environment of the erythrocyte in a subarachnoid blood clot. It has long been suspected that, due to its potent vasoactivity, erythrocyte lysate provides the major vasoconstrictive input to cerebral arteries during vasospasm. Under the model conditions (incubation at 37°C in an artificial cerebrospinal fluid), however, the rate of spontaneous hemolysis was quite slow (about 1%/day), becoming only somewhat more rapid after 4 day

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16

Howe, C. L., L. M. Sacramone, M. S. Mooseker, and J. S. Morrow. "Mechanisms of cytoskeletal regulation: modulation of membrane affinity in avian brush border and erythrocyte spectrins." Journal of Cell Biology 101, no. 4 (1985): 1379–85. http://dx.doi.org/10.1083/jcb.101.4.1379.

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The spectrins isolated from chicken erythrocytes and chicken intestinal brush border, TW260/240, share a common alpha subunit and a tissue-specific beta subunit. The ability of these related proteins to bind human erythrocyte inside out vesicles (IOVs) and human erythrocyte ankyrin in vitro have been quantitatively compared with human erythrocyte spectrin. Chicken erythrocyte spectrin binds human IOVs and human ankyrin with affinities nearly identical to that for human erythrocyte spectrin. TW260/240 does not significantly bind to either IOVs or ankyrin. These results demonstrate a remarkable

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17

Sun, Kaiqi, Hong Liu, Anren Song, et al. "Erythrocyte purinergic signaling components underlie hypoxia adaptation." Journal of Applied Physiology 123, no. 4 (2017): 951–56. http://dx.doi.org/10.1152/japplphysiol.00155.2017.

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Erythrocytes are vital to human adaptation under hypoxic conditions because of their abundance in number and irreplaceable function of delivering oxygen (O2). However, although multiple large-scale altitude studies investigating the overall coordination of the human body for hypoxia adaptation have been conducted, detailed research with a focus on erythrocytes was missing due to lack of proper techniques. The recently maturing metabolomics profiling technology appears to be the answer to this limitation. Metabolomics profiling provides unbiased high-throughput screening data that reveal the ov

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Chen, Shao-Yin, Yulei Wang, Marilyn I. Telen, and Jen-Tsan A. Chi. "The Identification and Genomic Analysis of microRNAs in Human Erythrocytes in Sickle Cell Diseases." Blood 110, no. 11 (2007): 3400. http://dx.doi.org/10.1182/blood.v110.11.3400.3400.

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Abstract Erythrocytes are circulating blood cells responsible for efficient gas exchange in human body. Since mature erythrocytes are terminally differentiated cells without nuclei and organelles, it is commonly thought that they do not contain nucleic acids. In this study, we re-examined this issue and found that human mature erythrocytes, while lacking ribosomal and large-sized RNAs, possess abundant small-sized RNAs. Using a combination of microarray analysis, real-time RT-PCR and Northern blots we found that mature erythrocytes contained abundant and diverse microRNAs which were distinct f

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Fowler, V. M., J. Q. Davis, and V. Bennett. "Human erythrocyte myosin: identification and purification." Journal of Cell Biology 100, no. 1 (1985): 47–55. http://dx.doi.org/10.1083/jcb.100.1.47.

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Human erythrocytes contain an Mr 200,000 polypeptide that cross-reacts specifically with affinity-purified antibodies to the Mr 200,000 heavy chain of human platelet myosin. Immunofluorescence staining of formaldehyde-fixed erythrocytes demonstrated that the immunoreactive myosin polypeptide is present in all cells and is localized in a punctate pattern throughout the cell. Between 20-40% of the immunoreactive myosin polypeptide remained associated with the membranes after hemolysis and preparation of ghosts, suggesting that it may be bound to the membrane cytoskeleton as well as being present

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Spolarics, Zoltán, Michael R. Condon, Muhammad Siddiqi, George W. Machiedo, and Edwin A. Deitch. "Red blood cell dysfunction in septic glucose-6-phosphate dehydrogenase-deficient mice." American Journal of Physiology-Heart and Circulatory Physiology 286, no. 6 (2004): H2118—H2126. http://dx.doi.org/10.1152/ajpheart.01085.2003.

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Glucose-6-phosphate dehydrogenase (G-6-PDH) deficiency is the most common known human genetic polymorphism. This study tested the hypothesis that G-6-PDH deficiency worsens sepsis-induced erythrocyte dysfunction. Sepsis (24 h) was induced by cecal ligation and puncture in wild-type (WT) and G-6-PDH-deficient (G-6-PDH activity 15% of WT) mice. Erythrocyte responses were tested in whole blood as well as in subpopulations of circulating erythrocytes. Whereas erythrocyte deformability was similar in unchallenged deficient and WT animals, sepsis decreased erythrocyte deformability that was more pro

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Luo, Gang-Yue, Li Sun, and Timon Cheng-Yi Liu. "Aquaporin-1-Mediated Effects of Low Level He-Ne Laser Irradiation on Human Erythrocytes." International Journal of Photoenergy 2012 (2012): 1–5. http://dx.doi.org/10.1155/2012/275209.

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The role of membrane aquaporin-1 (APQ-1) in the photobiomodulation (PBM) on erythrocyte deformability will be studied in this paper with human dehydrated erythrocytes as echinocytic shape alterations lead to decreased cellular deformability. Human dehydrated erythrocytes were irradiated with low intensity He-Ne laser irradiation (LHNL) at 0.9, 1.8, 2.7, and 4.4 mW/cm2for 5, 15, and 30 min, respectively, and APQ-1 inhibitor, 0.2 μmol/L HgCl2, was used to study the role of APQ-1 in mediating PBM with LHNL at 4.4 mW/cm2for 5 min. Comprehensive morphological parameters of an intact cell such as co

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Signoretto, Elena, Michela Castagna, Abdulla Al Mamun Bhuyan, and Florian Lang. "Stimulating Effect of Terfenadine on Erythrocyte Cell Membrane Scrambling." Cellular Physiology and Biochemistry 38, no. 4 (2016): 1425–34. http://dx.doi.org/10.1159/000443085.

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Background/Aims: The antihistaminic drug Terfenadine may trigger apoptosis of tumor cells, an effect unrelated to its effect on histamine receptors. Similar to apoptosis of nucleated cells, erythrocytes may enter eryptosis, the suicidal death of erythrocytes characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface. Signaling triggering eryptosis include increase of cytosolic Ca2+ activity ([Ca2+]i), oxidative stress, and ceramide. The present study explored, whether Terfenadine is capable to trigger eryptosis. Methods: Flow c

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Hair, Pamela, Daniel W. Goldman, Jessica Li, Michelle Petri, Neel Krishna, and Kenji Cunnion. "Classical complement activation on human erythrocytes in subjects with systemic lupus erythematosus and a history of autoimmune hemolytic anemia." Lupus 29, no. 10 (2020): 1179–88. http://dx.doi.org/10.1177/0961203320936347.

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Introduction Autoimmune hemolytic anemia (AIHA) is a serious manifestation of systemic lupus erythematosus (SLE) associated with significant morbidity and mortality. In order to more fully understand the causative pathways, we utilized sera from subjects with SLE and active AIHA, or a history of AIHA, to evaluate the classical complement pathway, anti-erythrocyte antibodies, and immune complexes. Methods To evaluate antibody-mediated complement activation on the surface of erythrocytes, as occurs in AIHA, blood type O erythrocytes were incubated with sera from 19 subjects with SLE and a histor

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Nakagawa, Kiyotaka, Takehiro Kiko, Taiki Miyazawa, et al. "Antioxidant effect of astaxanthin on phospholipid peroxidation in human erythrocytes." British Journal of Nutrition 105, no. 11 (2011): 1563–71. http://dx.doi.org/10.1017/s0007114510005398.

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Phospholipid hydroperoxides (PLOOH) accumulate abnormally in the erythrocytes of dementia patients, and dietary xanthophylls (polar carotenoids such as astaxanthin) are hypothesised to prevent the accumulation. In the present study, we conducted a randomised, double-blind, placebo-controlled human trial to assess the efficacy of 12-week astaxanthin supplementation (6 or 12 mg/d) on both astaxanthin and PLOOH levels in the erythrocytes of thirty middle-aged and senior subjects. After 12 weeks of treatment, erythrocyte astaxanthin concentrations were higher in both the 6 and 12 mg astaxanthin gr

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Ivanov, Ivan T., and Boyana K. Paarvanova. "Role of Plasma Membrane at Dielectric Relaxations and Intermembrane Interaction in Human Erythrocytes." Membranes 13, no. 7 (2023): 658. http://dx.doi.org/10.3390/membranes13070658.

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Dielectric relaxations at 1.4 MHz (βsp) and 9 MHz (γ1sp) on the erythrocyte spectrin network were studied by dielectric spectroscopy using dense suspensions of erythrocytes and erythrocyte ghost membranes, subjected to extraction with up to 0.2% volume Triton-X-100. The step-wise extraction of up to 60% of membrane lipids preserved γ1sp and gradually removed βsp-relaxation. On increasing the concentration up to 100 mM of NaCl at either side of erythrocyte plasma membranes, the βsp-relaxation was linearly enhanced, while the strength of γ1sp-relaxation remained unchanged. In media with NaCl bet

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Campanella, M. Estela, Haiyan Chu, Nancy J. Wandersee, et al. "Characterization of glycolytic enzyme interactions with murine erythrocyte membranes in wild-type and membrane protein knockout mice." Blood 112, no. 9 (2008): 3900–3906. http://dx.doi.org/10.1182/blood-2008-03-146159.

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Previous research has shown that glycolytic enzymes (GEs) exist as multienzyme complexes on the inner surface of human erythrocyte membranes. Because GE binding sites have been mapped to sequences on the membrane protein, band 3, that are not conserved in other mammalian homologs, the question arose whether GEs can organize into complexes on other mammalian erythrocyte membranes. To address this, murine erythrocytes were stained with antibodies to glyceraldehyde-3-phosphate dehydrogenase, aldolase, phosphofructokinase, lactate dehydrogenase, and pyruvate kinase and analyzed by confocal microsc

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Spinedi, A., L. Pacini, C. Limatola, P. Luly, and R. N. Farias. "A study of human erythrocyte acetylcholinesterase inhibition by chlorpromazine." Biochemical Journal 278, no. 2 (1991): 461–63. http://dx.doi.org/10.1042/bj2780461.

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Membrane-bound acetylcholinesterase (AChE) from the human erythrocyte is inhibited by chlorpromazine (CPZ) in a concentration range within this amphiphilic drug has been demonstrated to interact with erythrocyte membranes, causing a large spectrum of physical and structural effects; membrane solubilization with 0.5% Triton X-100 results in a complete loss of CPZ inhibitory potency. Although these observations might suggest a role of membrane lipid environment in mediating human erythrocyte AChE inhibition, we observed that CPZ retains its full inhibitory effect on the fraction of enzyme (5-6%

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Tham, Wai-Hong, Danny W. Wilson, Linda Reiling, Lin Chen, James G. Beeson, and Alan F. Cowman. "Antibodies to Reticulocyte Binding Protein-Like Homologue 4 Inhibit Invasion of Plasmodium falciparum into Human Erythrocytes." Infection and Immunity 77, no. 6 (2009): 2427–35. http://dx.doi.org/10.1128/iai.00048-09.

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ABSTRACT Plasmodium falciparum invasion into human erythrocytes relies on the interaction between multiple parasite ligands and their respective erythrocyte receptors. The sialic acid-independent invasion pathway is dependent on the expression of P. falciparum reticulocyte binding protein-like homologue 4 (PfRh4), as disruption of the gene abolishes the ability of parasites to switch to this pathway. We show that PfRh4 is present as an invasion ligand in culture supernatants as a 160-kDa proteolytic fragment. We confirm that PfRh4 binds to the surfaces of erythrocytes through recognition of an

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Bewaji, C. O., and E. A. Bababunmi. "Abundance of the Ca2+-pumping ATPase in pig erythrocyte membranes." Biochemical Journal 248, no. 1 (1987): 297–99. http://dx.doi.org/10.1042/bj2480297.

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The Ca2+-pumping ATPase (Ca2+-ATPase) was purified from human and pig erythrocyte membranes by calmodulin affinity chromatography in the presence of phosphatidylcholine. The amount of enzyme present in pig erythrocytes is at least 7 times greater than that isolated from human erythrocyte ghosts. However, the properties of the enzyme from the two species are similar in many respects.

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BAX, Bridget E., Murray D. BAIN, Peter J. TALBOT, E. John PARKER-WILLIAMS, and Ronald A. CHALMERS. "Survival of human carrier erythrocytes in vivo." Clinical Science 96, no. 2 (1999): 171–78. http://dx.doi.org/10.1042/cs0960171.

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Erythrocytes offer the exciting opportunity of being used as carriers of therapeutic agents. Encapsulation within erythrocytes will give the therapeutic agent a clearance equivalent to the normal life of the erythrocyte therefore maintaining therapeutic blood levels over prolonged periods and also giving a sustained delivery to the monocyte–macrophage system (reticulo-endothelial system). Both the dose and frequency of therapeutic interventions could thus be reduced. Ensuring a near-physiological survival time of carrier erythrocytes is essential to their successful use as a sustained drug del

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Davids, Mariska, Albert J. van Hell, Marlieke Visser, Robert J. Nijveldt, Paul A. M. van Leeuwen, and Tom Teerlink. "Role of the human erythrocyte in generation and storage of asymmetric dimethylarginine." American Journal of Physiology-Heart and Circulatory Physiology 302, no. 8 (2012): H1762—H1770. http://dx.doi.org/10.1152/ajpheart.01205.2011.

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Proteolytic activity in whole blood may lead to release of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA). We investigated the role of the human erythrocyte in storage and generation of ADMA in healthy controls ( n = 36) and critically ill patients ( n = 38). Both free and total (sum of free and protein-incorporated) ADMA were measured. Upon incubation of intact erythrocytes with extracellular ADMA (0 to 40 μmol/l), equilibrium between intra- and extracellular ADMA was reached within 3 h. Compared with controls, patients had significantly higher basal concent

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Petrov, V., and P. Lijnen. "Regulation of human erythrocyte Na+/H+ exchange by soluble and particulate guanylate cyclase." American Journal of Physiology-Cell Physiology 271, no. 5 (1996): C1556—C1564. http://dx.doi.org/10.1152/ajpcell.1996.271.5.c1556.

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Guanylate cyclase activity in human erythrocytes is investigated by evaluating the intracellular guanosine 3',5'-cyclic monophosphate (cGMP) content in the presence of various agents that exert specific effects on soluble or particulate guanylate cyclase. The increase in the intraerythrocyte cGMP content by the soluble guanylate cyclase activators nitroprusside and NaNO2 suggests the presence of this enzyme in human erythrocytes. The effects of four different atrial natriuretic peptide (ANP) fragments on the intraerythrocyte cGMP content is also studied. ANP II and ANP III increase the intraer

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Adderley, Shaquria P., Eileen A. Dufaux, Meera Sridharan, et al. "Iloprost- and isoproterenol-induced increases in cAMP are regulated by different phosphodiesterases in erythrocytes of both rabbits and humans." American Journal of Physiology-Heart and Circulatory Physiology 296, no. 5 (2009): H1617—H1624. http://dx.doi.org/10.1152/ajpheart.01226.2008.

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Activation of the G protein Gs results in increases in cAMP, a necessary step in the pathway for ATP release from rabbit and human erythrocytes. In all cells, the level of cAMP is the product of its synthesis by adenylyl cyclase and its hydrolysis by phosphodiesterases (PDEs). Both iloprost (Ilo), a PGI2 analog, and isoproterenol (Iso), a β-agonist, stimulate receptor-mediated increases in cAMP in rabbit and human erythrocytes. However, the specific PDEs associated with each of these signaling pathways in the erythrocyte have not been fully characterized. Previously, we reported that PDE3B is

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Schülein, Ralf, Anja Seubert, Christian Gille, et al. "Invasion and Persistent Intracellular Colonization of Erythrocytes." Journal of Experimental Medicine 193, no. 9 (2001): 1077–86. http://dx.doi.org/10.1084/jem.193.9.1077.

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The expanding genus Bartonella includes zoonotic and human-specific pathogens that can cause a wide range of clinical manifestations. A productive infection allowing bacterial transmission by blood-sucking arthropods is marked by an intraerythrocytic bacteremia that occurs exclusively in specific human or animal reservoir hosts. Incidental human infection by animal-adapted bartonellae can cause disease without evidence for erythrocyte parasitism. A better understanding of the intraerythrocytic lifestyle of bartonellae may permit the design of strategies to control the reservoir and transmittab

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Almukadi, Haifa, Christopher Schwake, Maima M. Kaiser, et al. "Human erythrocyte band 3 is a host receptor for Plasmodium falciparum glutamic acid–rich protein." Blood 133, no. 5 (2019): 470–80. http://dx.doi.org/10.1182/blood-2018-07-865451.

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Abstract Malaria remains a major global threat to human health and economic development. Microvascular lesions caused by Plasmodium falciparum–infected human erythrocytes/red blood cells are hallmarks of severe pathogenesis contributing to high mortality, particularly in children from sub-Saharan Africa. In this study, we used a phage display complementary DNA library screening strategy to identify P falciparum glutamic acid–rich protein (PfGARP) as a secreted ligand that recognizes an ectodomain of human erythrocyte anion-exchanger, band 3/AE1, as a host receptor. Domain mapping of PfGARP rev

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Chitnis, C. E., and L. H. Miller. "Identification of the erythrocyte binding domains of Plasmodium vivax and Plasmodium knowlesi proteins involved in erythrocyte invasion." Journal of Experimental Medicine 180, no. 2 (1994): 497–506. http://dx.doi.org/10.1084/jem.180.2.497.

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Plasmodium vivax and the related monkey malaria, P. knowlesi, require interaction with the Duffy blood group antigen, a receptor for a family of chemokines that includes interleukin 8, to invade human erythrocytes. One P. vivax and three P. knowlesi proteins that serve as erythrocyte binding ligands in such interactions share sequence homology. Expression of different regions of the P. vivax protein in COS7 cells identified a cysteine-rich domain that bound Duffy blood group-positive but not Duffy blood group-negative human erythrocytes. The homologous domain of the P. knowlesi proteins also b

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Linko, Anna-Maria, and Herman Adlercreutz. "Whole-grain rye and wheat alkylresorcinols are incorporated into human erythrocyte membranes." British Journal of Nutrition 93, no. 1 (2005): 11–13. http://dx.doi.org/10.1079/bjn20041281.

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Alkylresorcinols (AR), a group of phenolic lipids, exist in the human diet in whole-grain rye and wheat. They are absorbed by humans and have been quantified in plasma. In this 2-week study we assessed AR incorporation into human erythrocyte membranes. Nine subjects attended the study; four avoided whole-grain products for 1 week and then included whole-grain rye and wheat bread in the diet for the second week, four included whole-grain rye and wheat products in the diet during the whole follow-up and one followed a gluten-free diet. Plasma and erythrocyte membrane AR were analysed after weeks

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Murali, J., D. Koteeswari, J. M. Rifkind, and R. Jayakumar. "Amyloid insulin interaction with erythrocytes." Biochemistry and Cell Biology 81, no. 1 (2003): 51–59. http://dx.doi.org/10.1139/o03-009.

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Erythrocyte membrane interactions with insulin fibrils (amyloid) have been investigated using centrifugation, fluorescence spectroscopy, light scattering, and flow cytometric techniques. The results indicate that insulin fibrils are having moderate affinity to erythrocyte membrane. However, analysis of the apparent dissociation constants of human erythrocyte membranes (leaky and resealed vesicles) with amyloid insulin reveal that the insulin binding is drastically reduced on attaining the fibrillar state compared with native insulin. To understand the role of insulin receptors on erythrocytes

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Generalov, V. M., A. S. Safatov, M. V. Kruchinina, et al. "Dielectric properties of the human red blood cell." Izmeritel`naya Tekhnika, no. 7 (2020): 62–67. http://dx.doi.org/10.32446/0368-1025it.2020-7-62-67.

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The dielectric properties of the erythrocyte were studied. Experimental methods and results of measuring the dielectric properties of individual human erythrocyte are presented. The method is theoretically justified. It is established that values of the complex permittivity of the erythrocyte, capacitance, tangent of dielectric losses remains almost constant despite significant changes in conductivity, the content of NaCl of the cell suspension. These values reflect the stability of the studied parameters of erythrocytes under conditions of changes within a wide range of the environment in whi

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Suwalsky, M., P. Hernández, F. Villena, F. Aguilar, and C. P. Sotomayor. "Interaction of the Anticancer Drug Tamoxifen with the Human Erythrocyte Membrane and Molecular Models." Zeitschrift für Naturforschung C 53, no. 3-4 (1998): 182–90. http://dx.doi.org/10.1515/znc-1998-3-407.

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Abstract Tamoxifen, Anticancer Drug, Erythrocyte Membrane, Phospholipid Bilayer Tamoxifen is a non steroidal antiestrogen drug extensively used in the prevention and treatment of hormone-dependent breast cancer. To evaluate its perturbing effect upon cell membranes it was made to interact with human erythrocytes and molecular models. These consisted of bilayers of dimyristoylphosphatidylcholine (DMPC) and of dimyristoylphospha-tidylethanolamine (DMPE), representative of phospholipids classes located in the outer and inner leaflets of the erythrocyte membrane, respectively. Experiments by fluor

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Misiti, Francesco, Federica Orsini, M. Elisabetta Clementi, et al. "Amyloid peptide inhibits ATP release from human erythrocytes." Biochemistry and Cell Biology 86, no. 6 (2008): 501–8. http://dx.doi.org/10.1139/o08-139.

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The oxygen required to meet metabolic needs of all tissues is delivered by the erythrocyte, a small, flexible cell, which, in mammals, is devoid of a nucleus and mitochondria. Despite its simple appearance, this cell has an important role in its own distribution, enabling the delivery of oxygen to precisely meet localized metabolic need. When an erythrocyte enters in a hypoxic area, a signalling pathway is activated within the cell resulting in the release of ATP in amounts adequate to activate purinergic receptors on vascular endothelium, which trigger secretion of nitric oxide and other fact

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Zhu, Qin Yan, Derek D. Schramm, Heidrun B. Gross, et al. "Influence of Cocoa Flavanols and Procyanidins on Free Radical-induced Human Erythrocyte Hemolysis." Clinical and Developmental Immunology 12, no. 1 (2005): 27–34. http://dx.doi.org/10.1080/17402520512331329514.

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Cocoa can be a rich source of antioxidants including the flavan-3-ols, epicatechin and catechin, and their oligomers (procyanidins). While these flavonoids have been reported to reduce the rate of free radical-induced erythrocyte hemolysis in experimental animal models, little is known about their effect on human erythrocyte hemolysis. The major objective of this work was to study the effect of a flavonoid-rich cocoa beverage on the resistance of human erythrocytes to oxidative stress. A second objective was to assess the effects of select purified cocoa flavonoids, epicatechin, catechin, the

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43

ZINTL, A., C. WESTBROOK, H. E. SKERRETT, J. S. GRAY, and G. MULCAHY. "Chymotrypsin and neuraminidase treatment inhibits host cell invasion by Babesia divergens (Phylum Apicomplexa)." Parasitology 125, no. 1 (2002): 45–50. http://dx.doi.org/10.1017/s0031182002001798.

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The process of host cell invasion by Babesia divergens is poorly understood and improved knowledge of the mechanism involved could lead to development of measures effective in disease prevention. To investigate parasite ligands on the erythrocyte surface, B. divergens cultures in bovine erythrocytes were transferred into enzyme-treated bovine, human, ovine and equine erythrocytes. Parasite invasion of bovine erythrocytes was not affected by trypsin treatment while treatment with alpha-chymotrypsin led to a reduction in parasite growth of 20–40%. Treatment of bovine and non-bovine erythrocytes

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Suzuki, Y., N. Tateishi, and N. Maeda. "Electrostatic repulsion among erythrocytes in tube flow, demonstrated by the thickness of marginal cell‐free layer." Biorheology: The Official Journal of the International Society of Biorheology 35, no. 2 (1998): 155–70. http://dx.doi.org/10.1177/0006355x1998035002005.

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Electrostatic repulsion among erythrocytes in flow was evaluated through measurement of the thickness of the marginal cell‐free layer in narrow glass tubes of 20–50 $\mu$ m in inner diameter. To reduce the electrostatic repulsive force, due mainly to sialic acid of the membrane glycoproteins, human erythrocytes were treated with neuraminidase. The surface negative charge of the erythrocytes, as determined from the electrophoretic mobility using free‐flow electrophoresis, was found to be proportional to the sialic acid content. When erythrocytes with decreased sialic acid content flowed through

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Herrmann, Andreas, Peter Müller, and Roland Glaser. "Shape transformation of erythrocyte ghosts depends on ion concentrations." Bioscience Reports 5, no. 5 (1985): 417–23. http://dx.doi.org/10.1007/bf01116559.

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Resealed human erythrocyte ghosts undergo shape transformations similar to those of intact erythrocytes. The results indicate that the shape of these ghosts depends on the inner as well as on the outer NaCl concentration. A correlation between shape and calculated transmembrane potential was established similar to that for intact human erythrocytes.

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Chabanel, A., W. Reinhart, and S. Chien. "Increased resistance to membrane deformation of shape-transformed human red blood cells [published erratum appears in Blood 1987 Sep;70(3):893]." Blood 69, no. 3 (1987): 739–43. http://dx.doi.org/10.1182/blood.v69.3.739.739.

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Abstract The study of shape-transformed human erythrocytes is of hematological interest since several clinical conditions are associated with erythrocyte shape changes. Using the micropipette technique, we examined the rheological behaviors of echinocytes induced by sodium salicylate or ATP depletion and of stomatocytes induced by chlorpromazine. Both the discocyte-echinocyte and discocyte-stomatocyte transformations resulted in an increased resistance to extension. Sodium salicylate-treated erythrocytes could be returned to normal morphology and normal membrane rheology by addition of chlorpr

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47

Chabanel, A., W. Reinhart, and S. Chien. "Increased resistance to membrane deformation of shape-transformed human red blood cells [published erratum appears in Blood 1987 Sep;70(3):893]." Blood 69, no. 3 (1987): 739–43. http://dx.doi.org/10.1182/blood.v69.3.739.bloodjournal693739.

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The study of shape-transformed human erythrocytes is of hematological interest since several clinical conditions are associated with erythrocyte shape changes. Using the micropipette technique, we examined the rheological behaviors of echinocytes induced by sodium salicylate or ATP depletion and of stomatocytes induced by chlorpromazine. Both the discocyte-echinocyte and discocyte-stomatocyte transformations resulted in an increased resistance to extension. Sodium salicylate-treated erythrocytes could be returned to normal morphology and normal membrane rheology by addition of chlorpromazine.

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Altman, R. J., C. C. Smith, and J. Betteridge. "Catecholamine content of human erythrocytes." Clinical Chemistry 34, no. 10 (1988): 2120–22. http://dx.doi.org/10.1093/clinchem/34.10.2120.

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Abstract We used high-performance liquid chromatography with electrochemical detection to measure the catecholamine content of human erythrocytes. The ratio of free norepinephrine to epinephrine was three to four times lower than that in plasma and four to seven times lower than that in platelets. This suggests differences in uptake, degradation, or conjugation of norepinephrine and epinephrine by erythrocytes, as compared with plasma and platelets. Erythrocyte free norepinephrine was significantly greater (P less than 0.01) in women than in men.

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Waibel, Sabrina, Rosi Bissinger, Ghada Bouguerra, Salem Abbès, and Florian Lang. "Saquinavir Induced Suicidal Death of Human Erythrocytes." Cellular Physiology and Biochemistry 37, no. 5 (2015): 1973–82. http://dx.doi.org/10.1159/000438558.

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Background/Aims: The antiretroviral protease inhibitor saquinavir is used for the treatment of HIV infections. Effects of saquinavir include induction of apoptosis, the suicidal death of nucleated cells. Saquinavir treatment may further lead to anemia. In theory, anemia could result from accelerated erythrocyte loss by enhanced suicidal erythrocyte death or eryptosis, which is characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface. Stimulators of eryptosis include Ca2+ entry with increase of cytosolic Ca2+ activity ([Ca2+]i

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Tsai, HM, II Sussman, RL Nagel, and DK Kaul. "Desmopressin induces adhesion of normal human erythrocytes to the endothelial surface of a perfused microvascular preparation." Blood 75, no. 1 (1990): 261–65. http://dx.doi.org/10.1182/blood.v75.1.261.261.

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Abstract The interaction of red blood cells (RBCs) with vascular endothelium under flow conditions was investigated using the perfused rat mesocecum. Under videomicroscopy, normal human erythrocytes were found to adhere to the venular endothelium of desmopressin-treated microvasculature. Transmission electron microscopy showed that the erythrocytes were attached to the endothelial cells at discrete electron-dense sites. Compared with control preparations in which the microvasculature was perfused with Ringer's-albumin solution alone, more than a 10-fold increase in radioactivity was retained i

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