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Dissertations / Theses on the topic 'Estrogenic endocrine disruptors'

Author: Grafiati

Published: 26 July 2023

Last updated: 31 July 2025

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1

Swart, Johannes Cornelius. "The development and implementation of biomarker assays for estrogenic endocrine disruptors." Thesis, University of the Western Cape, 2008. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_6792_1258011445.

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<p>'Endocrine disrupting chemicals (EDCs) are compounds found in the environment that have the potential to disrupt normal endocrine function. Estrogenic EDCs (e-EDCs) is a subclass of EDCs and is defined as substances contaminating the environment that may mimic or inhibit the effect of endogenous estrogen and therefore may influence developmental and reproductive health in humans and animals. The aim of this study was to develop, validate and implement a battery of in vitro and in vivo screening assays for e-EDCs. The study was concluded by implementing this battery of assays to assess the E

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2

Al-Jandal, Noura. "The effects of estrogenic endocrine disruptors on the osmoregulatory functions in euryhaline fish." Thesis, University of Exeter, 2011. http://hdl.handle.net/10036/3131.

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Osmoregulation is an essential process to maintain water and ionic balance and when euryhaline fish move between freshwater and seawater environments as part of their life cycle this presents additional osmoregulatory challenges. Migrating fish can be exposed in both environments to pollutants such as endocrine disrupting chemicals (EDCs) that include natural hormones (e.g. 17β-estradiol; E2), synthetic hormones (e.g. 17α-ethinylestradiol; EE2), and industrial chemicals (e.g. nonylphenol). The focus of this thesis was to study the effects of different categories of EDCs on the osmoregulatory f

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3

Teske, Sondra Sue Gery. "Aspects of Measuring Mass Balances of Endocrine Disrupting Compounds through Wastewater Treatment." Diss., The University of Arizona, 2009. http://hdl.handle.net/10150/194944.

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Ecological impacts of natural estrogens and xenoestrogens in treated wastewater include altered sexual development and sex ratios among continuously exposed organisms. The primary sources of estrogenic activity in wastewater are natural estrogens such as estrone, 17β-estradiol and estriol and synthetic compounds like 17α- ethinylestradiol, alkylphenols and alklphenol ethoxylates. Precursors in raw wastewater can yield estrogenic intermediates during wastewater treatment. All these compounds can be destroyed by biochemical processes conventional wastewater treatment processes, suggesting that c

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4

Blavier, Julie. "Degradation of estrogenic endocrine disruptors by laccases: from estrogenicity monitoring methods to reactor design." Doctoral thesis, Universite Libre de Bruxelles, 2015. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/222520.

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In the past decades, much concern has been expressed regarding organic micropollutants generating endocrine disruption. In particular, estrogenic endocrine disruptors, compounds that interfere with the estrogenic hormonal mechanisms, are in the center of environmental scien- tists attention. Numerous endocrine disrupting effects have been observed at concentrations corresponding to those found in aquatic environments, such as feminization of fauna, infertility, reproductive disturbance, cancer, or developmental disruption. Wastewater treatment plants ef- fluents have been identified as the mai

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5

Le, Fol Vincent. "Approche in vivo/in vitro du métabolisme de perturbateurs endocriniens chez le poisson zèbre (Danio rerio)." Phd thesis, Toulouse, INPT, 2015. http://oatao.univ-toulouse.fr/15125/1/lefol_1.pdf.

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Les perturbateurs endocriniens (PE) posent des risques pour la santé Humaine et pour la faune. L’utilisation de tests biologiques basés sur des mécanismes d’action spécifiques permet de caractériser le potentiel PE des substances chimiques dans le cadre de l'évaluation toxicologique, mais les capacités de biotransformation de ces modèles sont rarement prises en compte. Or, le métabolisme conditionne le devenir des xénobiotiques (détoxication vs. bioactivation) et donc in fine l'activité biologique mesurée. Dans ce travail, le devenir de deux contaminants œstrogéniques émergents (benzophénone-2

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6

Cox, Brian Joseph. "Development of an assay for estrogenic endocrine disrupters involving the rat liver estrogen receptor alpha." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ31820.pdf.

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7

Wu, Fei. "Comparative activation of estrogen receptor alpha (er alpha) by endocrine disruptors." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-2433.

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8

Zhao, Zunyang. "Removal of Estrogens at Full and Pilot Scale Livestock Manure Treatment Systems." Diss., Virginia Tech, 2008. http://hdl.handle.net/10919/26067.

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Three experiments were conducted to 1) develop appropriate methods for livestock manure estrogen analysis; 2) determine estrogen removal in different manure treatment systems; and 3) determine estrogen removal from dairy manure in pilot scale reactors. In Experiment I, the recoveries of 17Ã -estradiol (E2) and estriol (E3) were evaluated in double distilled water and dairy manure after a base extraction and analysis of estrogens by enzyme-linked immunoassay (ELISA) and yeast estrogen screen (YES) assay. The recoveries of E2 were 104% (ELISA) and 97% (YES) in double distilled water. 112% of E2

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9

Kwekel, Joshua Caleb. "Cross-species comparison of estrogenic endocrine disruptor-induced, uterotrophic gene expression in the rodent." Diss., Connect to online resource - MSU authorized users, 2008.

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10

Shimada, Kiyoshi, Yonju Ha, Akira Tsukada, et al. "In vivo and in vitro screening of endocrine disrupting chemicals with estrogenic activity in Japanese quail." Science Reviews 2000 Ltd, 2005. http://hdl.handle.net/2237/9265.

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11

Chen, Gunilla. "Changes in adipose tissue mRNA expression due to perinatal exposure to bisphenol A in rats." Thesis, Uppsala universitet, Institutionen för kvinnors och barns hälsa, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-235115.

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Bisphenol A (BPA) is an estrogen receptor binding chemical, widely used in the plastics industry, and as such commonly encountered from plastic containers etc. Even at very low doses, BPA is believed to induce obesity and to have various endocrine disruptive effects. The purpose of this study was to determine possible gene expression changes in gonadal and inguinal adipose tissue from rats perinatally exposed to BPA. The method used was quantitative real-time PCR, and genes found to be up-regulated were PLZF, adiponectin, RXRa and Tcf21, while down-regulated genes were PPARγ, Tmem26, EsR1, Res

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12

Coufal, Kendra. "A profile of oestrogrens and a survey of endocrine disrupters in marine turtles of Australia and Malaysia /." St. Lucia, Qld, 1998. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16547.pdf.

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13

Olowu, Rasaq Adewale. "Impedimetric and electrode kinetic dynamics of DNA aptamer nanobiosensors for estrogeneous endocrine disruptors." University of the Western Cape, 2011. http://hdl.handle.net/11394/8455.

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Philosophiae Doctor - PhD<br>In this work, DNA aptamer biosensor systems were developed for the detection of l7p-estradiol - an estrogeneous endocrine disrupting chemical (EDC). Endocrine disrupting chemicals are group of compounds that impact negatively on the endocrine system of humans and wildlife. High concentrations of l7p-estradiol in water or food chain disrupts the physiology of the endocrine system of various animal species, leading to feminisation in fish and stimulates the proliferation of cancer cells in humans. Aptasensor systems for the determination of l7pestradiol were prepared

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14

Holbrook, Richard David Jr. "Fate and Transport of Endocrine Disrupting Compounds during Wastewater Treatment: The Role of Colloidal and Particulate Material." Diss., Virginia Tech, 2003. http://hdl.handle.net/10919/28853.

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The presence of biologically-active estrogenic endocrine disrupting compounds (EDCs) in treated effluents from biological wastewater treatment facilities has prompted wide-spread interest in the behavior of these contaminants during the activated sludge process. The yeast-estrogen screen (YES) was used to quantify the estrogenic activity of samples taken from different areas of three wastewater treatment facilities. An estrogenic mass-balance around these facilities revealed that the majority of influent estrogenic activity was removed in the activated sludge process, but the main route for ED

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15

Bousoumah, Radia. "Le challenge de l’analyse multi-résidus de perturbateurs endocriniens à activité estrogénique dans les fluides et tissus biologiques humains : Choix de stratégies de préparation des échantillons et de mesure par spectrométrie de masse." Electronic Thesis or Diss., Paris, AgroParisTech, 2015. http://www.theses.fr/2015AGPT0028.

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Depuis plus d’une vingtaine d’années, la problématique des perturbateurs endocriniens (PE) mobilise la communauté scientifique et les pouvoirs publics en raison des effets néfastes, avérés ou suspectés, de ces composés sur la santé de l’Homme. En particulier, la génération de données d’exposition interne (imprégnation) chez certaines sous-populations reconnues ou supposées plus sensibles (femmes enceintes, foetus, nourrissons) est à la fois une priorité et un domaine exigeant associé à une certaine rareté. De par leur diversité au plan structural et en termes de propriétés physico-chimiques, l

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16

Yiu, Kwok Wing. "Measuring the binding between estrogen receptor alpha and potential endocrine disruptors by fluorescence polarization and total internal reflection fluorescence." HKBU Institutional Repository, 2013. http://repository.hkbu.edu.hk/etd_ra/1503.

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Mehrotra, Mamta. "Characterisation of electrochemical detection of oestrogen by using yeast oestrogen binding protein." Thesis, University of Canterbury. School of Biological Sciences, 2015. http://hdl.handle.net/10092/10223.

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Oestrogens are female sex hormones. Both natural and synthetic oestrogens have been found in many aquatic environments. There are three naturally occurring oestrogens – oestradiol, estriol and estrone. Oestradiol (correctly known as 17β oestradiol or E2) is a naturally occurring steroid hormone and is the most potent of these three. Diethylstilbestrol, dienestrol, quinestrol etc are synthetic oestrogens. These environmental steroidal and nonsteroidal oestrogens act as endocrine disruptors (EDs). Both types of oestrogens in the environmental samples can be quantified using several laboratory me

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18

Siegel, Jan. "Matematické modelování systému reverzní osmózy pro detekci estrogenů ve vodě." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2017. http://www.nusl.cz/ntk/nusl-316845.

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Estrogen compounds are a subgroup of the environmental pollutants named Endocrine Disrupting Chemicals. It is a large group of chemicals which are capable of causing hormonal imbalance of an organism and affecting its reproductive, developmental or behavioral functions. In the environment, they are found in very low concentrations (below ng/l). This makes their detection and elimination highly problematic. The Research Centre for Toxic Compounds in the Environment (RECETOX) has been developing an experimental device which employes reverse osmosis (RO) to concentrate the trace amounts of microp

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Hoffmann, Frauke. "Mating behavior as non-invasive biomarker in Xenopus laevis for the assessment of endocrine disrupting compounds." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://dx.doi.org/10.18452/16519.

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Hormonell wirksame Chemikalien, wie Pflanzenschutzmittel oder Pharmaka gelangen durch Abwässer in die Umwelt und akkumulieren vor allem in Oberflächengewässern. Ein erhöhtes Augenmerk liegt auf Substanzen, die durch (anti)androgene und (anti)östrogene Wirkungsweise die Reproduktion von Tieren und Menschen beeinträchtigen. Bei den bisherigen Nachweismethoden für diese Stoffe handelt es sich um invasive Methoden, die das Töten der Tiere beinhalten. Diesen Methoden mangelt es jedoch an der nötigen Sensitivität, um umweltrelevante Konzentrationen der endokrinen Disruptoren (EDs) nach Kurzzeitexpos

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20

Tan, Benjamin L. L. "Chemical and Biological Analyses of Selected Endocrine Disruptors in Wastewater Treatment Plants in South East Queensland, Australia." Thesis, Griffith University, 2007. http://hdl.handle.net/10072/365603.

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Studies in North America, Europe, Japan and Australia have reported the presence of endocrine disrupting compounds (EDCs) in wastewater treatment plants (WWTPs) effluent could affect physiological and reproductive function in exposed fish consistent with exposure to hormonally active chemicals. The occurrence of EDCs in rivers and receiving environments situated near WWTPs raises concern over the removal efficacy of these compounds by conventional treatment processes. The main aim of this study was to utilize chemical analyses to assess concentrations of selected endocrine disruptors as well

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Guimarães, Tatiane Sant\'Ana. "Detecção e quantificação dos hormônios sexuais 17 \'beta\'-estradiol (E2), estriol (E3), estrona (E1) e 17 \'alfa\'-etinilestradiol (EE2) em água de abastecimento: estudo de caso da cidade de São Carlos, com vistas ao saneamento ambiental." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/18/18138/tde-26022009-100015/.

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Um dos grandes problemas da engenharia ambiental é a contaminação dos corpos hídricos. Os sanitaristas têm se preocupado com os hormônios sexuais, notadamente os estrógenos, compostos extremamente ativos biologicamente, que têm sido referidos como agentes etiológicos de feminilização e de vários tipos de cânceres. Os estrógenos naturais 17 \'beta\'-estradiol (E2), estriol (E3), estrona (E1) e o sintético 17 \'alfa\'-etinilestradiol (EE2), desenvolvidos para uso médico em terapias de reposição hormonal feminina e métodos contraceptivos, são os que despertam maiores preocupações, pela contínua i

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Gerolin, Eleonilce Rosa Rossi. "Ocorrencia e remoção de disruptores endocrinos em aguas utilizadas para abastecimento publico de Campinas e Sumare - SP." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/257939.

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Orientador: Ricardo de Lima Isaac<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia Civil, Arquitetura e Urbanismo<br>Made available in DSpace on 2018-08-12T13:40:20Z (GMT). No. of bitstreams: 1 Gerolin_EleonilceRosaRossi_D.pdf: 4382249 bytes, checksum: 11ae4682864ae425b2aad5ee5844f76c (MD5) Previous issue date: 2008<br>Resumo: A ocorrência de compostos considerados disruptores endócrinos (DE) em efluente de Estação de Tratamento de Esgoto (ETE) e em águas superficiais em concentrações de risco para animais silvestres constitui campo de pesquisa de elevado inte

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23

Slater, Heather. "Development of a chemical analysis protocol and application with whole estrogenic and androgenic assays to assess endocrine disruptor activity during wastewater and sludge treatment processes." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/48628.

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Wastewater and sludge treatment can decrease or increase estrogenic activity through degradation and transformation processes. Endocrine disrupting chemicals (EDCs) tend to adsorb to solids and partition into sludge during the wastewater treatment process. Analytical procedures to detect EDCs in sludge media can be time / labour intensive and require expensive analytical instrumentation. As a result, little information is available on EDC content or fate in municipal sludge. A gas chromatography-mass spectrometry (GC-MS) chemical analysis procedure to detect estrogens in mixed and digested

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Verbinnen, Raphael Teixeira. "Avaliação da atividade estrogênica das águas do rio Itapecuru no município de Bacabeira-MA." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/75/75135/tde-26012015-112322/.

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O rio Itapecuru foi investigado quanto a sua atividade estrogênica por meio das técnicas de ecotoxicologia aquática e de cromatografia líquida. No município de Bacabeira, amostras de água do rio Itapecuru foram coletadas no ponto de captação do sistema de abastecimento público de água que atende cerca da metade da população de São Luís, capital do Maranhão. Elas foram utilizadas na realização de ensaios ecotoxicológicos crônicos de 21 dias com Danio rerio e Oreochromis niloticus. A VTG nestes organismos-teste foi quantificada por meio do ensaio imunoenzimático ELISA, cujos resultados indicaram

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Dell\'Acqua, Marcelo Marques. "Efeito do hormônio 17α-etinilestradiol sobre a biologia de Chironomus sancticaroli (Chironomidae, Diptera)." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/18/18138/tde-09062017-152252/.

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A água constitui um dos compostos de maior distribuição e importância na crosta terrestre. Sua importância para vida está no fato de que nenhum processo metabólico ocorre sem a sua ação direta ou indireta. Entre os vários compostos contaminantes dos ambientes aquáticos, os hormônios, estrógenos naturais e sintéticos, devem ser vistos com uma maior importância, devido a sua persistência no ambiente. O 17α-etinilestradiol (EE2) é um hormônio sintético utilizado na formulação de contraceptivos orais, transdérmico e injetáveis. O presente estudo tem como objetivo analisar o efeito do hormônio

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26

Ajj, Hussein. "Influence des micropolluants en mélange sur la croissance de tumeurs testiculaires d'origine germinale." Thesis, Université de Lorraine, 2014. http://www.theses.fr/2014LORR0215/document.

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L’incidence des cancers testiculaires a fortement augmenté au cours des 50 dernières années. Des études épidémiologiques in vitro et in vivo, ont montré que l’exposition des hommes aux perturbateurs endocriniens est impliquée dans l’initiation et la progression du cancer du testicule (Beiki et al., 2010). L’exposition fœtale à ces produits pourrait provoquer des altérations de la différenciation des cellules germinales (CGs) au cours leur développement pendant la vie fœtale. Au cours de cette thèse, nous nous sommes intéressés à déterminer le rôle des perturbateurs endocriniens œstrogéno-mimét

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27

Julien, Benoit. "Caractérisation des effets métaboliques d’un mélange de polluants à faibles doses dans un modèle de souris déficientes en oestrogènes." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSE1092.

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La ménopause est un facteur de risques associé au développement des maladies métaboliques. Du fait de ce déficit hormonal, les femmes ménopausées pourraient présenter des risques particuliers une fois exposées à des agents chimiques capables de perturber le système endocrinien. Pour en savoir plus, nous avons mis au point un modèle de souris ovariectomisées supplémentées ou non en œstradiol (E2), et exposées de manière chronique à un mélange de polluants (TCDD, PCB153, DEHP et BPA) ajoutés à une alimentation obésogène. Chaque polluant est utilisé à une dose équivalente à la Dose Journalière To

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28

Essandoh, Helen M. K. "Efficiency of soil aquifer treatment in the removal of wastewater contaminants and endocrine disruptors. A study on the removal of triclocarban and estrogens and the effect of chemical oxygen demand and hydraulic loading rates on the reduction of organics and nutrients in the unsaturated and saturated zones of the aquifer." Thesis, University of Bradford, 2011. http://hdl.handle.net/10454/5710.

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This study was carried out to evaluate the performance of Soil Aquifer Treatment (SAT) under different loading regimes, using wastewater of much higher strength than usually encountered in SAT systems, and also to investigate the removal of the endocrine disruptors triclocarban (TCC), estrone (E1), 17¿-estradiol (E2) and 17¿- ethinylestradiol (EE2). SAT was simulated in the laboratory using a series of soil columns under saturated and unsaturated conditions. Investigation of the removal of Chemical Oxygen Demand (COD), Biochemical Oxygen Demand (BOD), Dissolved Organic Carbon (DOC), nit

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Essandoh, Helen Michelle Korkor. "Efficiency of soil aquifer treatment in the removal of wastewater contaminants and endocrine disruptors : a study on the removal of triclocarban and estrogens and the effect of chemical oxygen demand and hydraulic loading rates on the reduction of organics and nutrients in the unsaturated and saturated zones of the aquifer." Thesis, University of Bradford, 2011. http://hdl.handle.net/10454/5710.

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This study was carried out to evaluate the performance of Soil Aquifer Treatment (SAT) under different loading regimes, using wastewater of much higher strength than usually encountered in SAT systems, and also to investigate the removal of the endocrine disruptors triclocarban (TCC), estrone (E1), 17β-estradiol (E2) and 17α-ethinylestradiol (EE2). SAT was simulated in the laboratory using a series of soil columns under saturated and unsaturated conditions. Investigation of the removal of Chemical Oxygen Demand (COD), Biochemical Oxygen Demand (BOD), Dissolved Organic Carbon (DOC), nitrogen an

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Silva, Mariana Aguilera Alencar da. "Avaliação da neurotoxicidade do Bisfenol A em cultura primária de hipocampo." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/9/9141/tde-04102016-152552/.

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O Bisfenol A (BPA) é usado na fabricação de plásticos de policarbonato e resinas epóxi. A exposição pré-natal a esse agente pode causar diversos efeitos, tais como: antecipação da puberdade, hiperplasia de próstata, diminuição do número de espermatozoides, diminuição dos níveis de testosterona, alteração do desenvolvimento e organização tecidual da glândula mamária, diminuição da resposta celular induzida por hormônios, câncer de mama, diabetes, doenças cardiovasculares, alterações das funções de enzimas hepáticas, além de efeitos sobre o desenvolvimento cognitivo. Poucos estudos avaliam os ef

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Mercado-Feliciano, Minerva. "Estrogenic Activity of the Polybrominated Diphenyl Ether Flame Retardant Mixture DE-71." Thesis, 2008. http://hdl.handle.net/1805/1603.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Polybrominated diphenyl ethers (PBDEs) are widely used flame retardants suspected to act as endocrine disruptors. We tested the commercial PBDE mixture DE-71 and its in vivo metabolites for estrogenic activity. MCF-7 breast cancer cells culture, ERE-luciferase gene expression, 3H-β-estradiol displacement from recombinant ERα, and ovariectomized (OVX) mice served as bioassays. Although DE-71 did not bind ERα, it was able to increase MCF-7 cell proliferation and this was prevented by the antiestrogen fulvestrant. DE-71 co-treatment red

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"Effect of dietary and environmental endocrine disruptors on estrogen metabolic enzyme expression." Thesis, 2009. http://library.cuhk.edu.hk/record=b6074976.

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Because of the structural resemblance to the female hormone, phytoestrogen is another important class of endocrine disruptor. In the present project, we evaluated the effects of phytoestrogens isoliquiritigenin (ILN), hesperetin (HES), genistein, (GEN) and naringenin (NAR) on estrogen metabolism and also their effects on MCF-7 tumor growth in ovariectomized nude mice. We found that these phytoestrogens had differential effect on MCF-7 xenografts. NAR and GEN had totally different responses in the tumor growth. In contrast, ILN and HES only deterred MCF-7 xenograft growth when CYP19 was overexp

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Medková, Jaroslava. "Optimalizace stanovení endokrinních disruptorů v čistírenských kalech a aplikace metody v reálných vzorcích." Master's thesis, 2012. http://www.nusl.cz/ntk/nusl-307047.

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Hormonaly active compounds in wastewaters represent nowdays a serious problem. Proceses currently used in watewater treatment plants (WWTP) are unefficient in removing these compounds from contaminated wastewaters. The compounds are supposed to sorb onto solid sludge elements and sediments. In this work seven endocrine disruptors were detected in the sludge samples from WWTPs. A new sensitive method for detection of seven selected endocrine disruptors (4-nonylphenol, bisphenol A, estriol, 17β-estradiol, estrone, 17α- ethynylestradiol, irgasan) was developed. The method is based on accelerated

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"Effect of endocrine disruptors on the synthesis of estrogen and corticotrophin-releasing hormone in vitro and in vivo." Thesis, 2011. http://library.cuhk.edu.hk/record=b6075154.

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Huang, Hui.<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 2011.<br>Includes bibliographical references (leaves 141-154).<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Abstract also in Chinese.

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Cotter, Kellie Anne. "Alternative splicing of estrogen receptor alpha: potential mechanism for endocrine disruption and adaptation in teleost fishes." Thesis, 2014. https://hdl.handle.net/2144/15399.

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Accumulating evidence from epidemiological, wildlife, and laboratory studies indicates that abnormalities of reproduction, development and physiology can be ascribed to environmental contaminants with biological activities. Many such contaminants disrupt essential hormone-regulated processes by virtue of their ability to interact with nuclear hormone receptors (endocrine disrupting chemicals, EDC). Of particular concern are chemicals that mimic or block estrogen signaling (xenoestrogens, XE) through their direct interaction with estrogen receptors (ER). The current model of XE action focuses o

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Dytczak, Magdalena Anna. "Using ozonation and alternating redox potential to increase nitrogen and estrogen removal while decreasing waste activated sludge production." 2008. http://hdl.handle.net/1993/3062.

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The effectiveness of partial ozonation of return activated sludge for enhancing denitrification and waste sludge minimization were examined. A pair of nitrifying sequencing batch reactors was operated in either aerobic or alternating anoxic/aerobic conditions, with one control and one ozonated reactor in each set. The amount of solids decreased with the ozone dose. Biomass in the anoxic/aerobic reactor was easier to destroy than in the aerobic one, generating approximately twice as much soluble chemical oxygen demand (COD) by cell lysis. Increased COD favoured production of extracellular poly

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Hill, Corinne E. "Effects of Developmental Exposures of Two Emerging Environmental Toxicants on Estrogen-Sensitive Endpoints." 2015. https://scholarworks.umass.edu/masters_theses_2/200.

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Abstract:

Thousands of synthetic chemicals have been released into the environment, causing widespread exposures of wildlife and humans alike. Some of these chemicals are known to disrupt aspects of hormone action thus inducing abnormalities in endocrine tissues and organs. Bisphenol S (BPS) and tetrabromobisphenol A (TBBPA), two largely unstudied chemicals commonly used in consumer products, are suspected to have endocrine disrupting properties based on their similar chemical structures to known endocrine disrupting chemicals (EDCs). To determine whether developmental exposure to BPS or TBBPA induced a

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Klammer, Holger. "Pharmakologische Untersuchungen zu endokrinen Effekten des UV-Filters Ethylhexyl-methoxycinnamat." Doctoral thesis, 2006. http://hdl.handle.net/11858/00-1735-0000-0006-ABC4-2.

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Adamusová, Hana. "Využití vysokoúčinných separačních metod pro analýzy biologicky aktivních látek." Doctoral thesis, 2017. http://www.nusl.cz/ntk/nusl-369437.

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Abstract:

In the first part of this doctoral thesis, a new analytical HPLC-MS/MS method for monitoring of concentration changes of 17β-estradiol (βE2) during in vitro mouse sperm capacitation was developed. Capacitation was performed for three initial concentrations of βE2 (200, 20 and 2 μg/L). For all the concentrations a similar trend for the total unbound βE2 was observed. In general, the βE2 concentration decreased to reach its minimum and then increased again. The position of the minimum differed for the individual tested βE2 concentrations. Experimentally obtained results were subjected to the kin

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