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Relevant bibliographies by topics / Ex vivo expanded cartilage cells

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Academic literature on the topic 'Ex vivo expanded cartilage cells'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Ex vivo expanded cartilage cells"

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Goh, Doreen, Yanmeng Yang, Eng Hin Lee, James Hoi Po Hui, and Zheng Yang. "Managing the Heterogeneity of Mesenchymal Stem Cells for Cartilage Regenerative Therapy: A Review." Bioengineering 10, no. 3 (2023): 355. http://dx.doi.org/10.3390/bioengineering10030355.

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Articular cartilage defects commonly result from trauma and are associated with significant morbidity. Since cartilage is an avascular, aneural, and alymphatic tissue with a poor intrinsic healing ability, the regeneration of functional hyaline cartilage remains a difficult clinical problem. Mesenchymal stem cells (MSCs) are multipotent cells with multilineage differentiation potential, including the ability to differentiate into chondrocytes. Due to their availability and ease of ex vivo expansion, clinicians are increasingly applying MSCs in the treatment of cartilage lesions. However, despi

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Jakob, Yvonne, Johann Kern, David Gvaramia, et al. "Suitability of Ex Vivo-Expanded Microtic Perichondrocytes for Auricular Reconstruction." Cells 13, no. 2 (2024): 141. http://dx.doi.org/10.3390/cells13020141.

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Tissue engineering (TE) techniques offer solutions for tissue regeneration but require large quantities of cells. For microtia patients, TE methods represent a unique opportunity for therapies with low donor-site morbidity and reliance on the surgeon’s individual expertise. Microtia-derived chondrocytes and perichondrocytes are considered a valuable cell source for autologous reconstruction of the pinna. The aim of this study was to investigate the suitability of perichondrocytes from microtia patients for autologous reconstruction in comparison to healthy perichondrocytes and microtia chondro

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Trubiani, O., R. Di Primio, T. Traini, et al. "Morphological and Cytofluorimetric Analysis of Adult Mesenchymal Stem Cells Expanded Ex Vivo from Periodontal Ligament." International Journal of Immunopathology and Pharmacology 18, no. 2 (2005): 213–21. http://dx.doi.org/10.1177/039463200501800204.

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Many adult tissues contain a population of stem cells that have the ability of regeneration after trauma, disease or aging. Recently, there has been great interest in mesenchymal stem cells and their roles in maintaining physiological structure tissues and their studies have been considered very important and intriguing after having shown that this cell population can be expanded ex vivo to regenerate tissues not only of the mesenchymal lineage, such as intervertebral disc cartilage, bone, tooth-associated tissue, cardiomyocytes, but also to differentiate into cells derived from other embryoni

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Krueger, Simone, Sophie Achilles, Julius Zimmermann, Thomas Tischer, Rainer Bader, and Anika Jonitz-Heincke. "Re-Differentiation Capacity of Human Chondrocytes in Vitro Following Electrical Stimulation with Capacitively Coupled Fields." Journal of Clinical Medicine 8, no. 11 (2019): 1771. http://dx.doi.org/10.3390/jcm8111771.

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Treatment of cartilage lesions remains a clinical challenge. Therefore, biophysical stimuli like electric fields seem to be a promising tool for chondrocytic differentiation and treatment of cartilage lesions. In this in vitro study, we evaluated the effects of low intensity capacitively coupled electric fields with an alternating voltage of 100 mVRMS (corresponds to 5.2 × 10−5 mV/cm) or 1 VRMS (corresponds to 5.2 × 10−4 mV/cm) with 1 kHz, on human chondrocytes derived from osteoarthritic (OA) and non-degenerative hyaline cartilage. A reduction of metabolic activity after electrical stimulatio

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Pei, Yixuan Amy, Jhanvee Patel, and Ming Pei. "Extracellular Matrix Tunes the Regenerative Potential of Fetal Stem Cells." Applied Sciences 14, no. 5 (2024): 1932. http://dx.doi.org/10.3390/app14051932.

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Adult mesenchymal stem cells (MSCs) are a promising cell source for tissue regeneration. However, ex vivo expansion results in cell senescence; cells lose their proliferation and differentiation capacity. Fetal MSCs can offer an alternative due to their robust proliferation and differentiation capacities, as well as their immune privilege properties. Given the rejuvenation effect of the decellularized extracellular matrix (dECM) on adult MSCs, it remains unknown whether dECM influences the regenerative potential of fetal stem cells. In this study, passage five fetal nucleus pulposus cells (fNP

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Busse, Dan. "Increased Knee Cartilage Volume in Degenerative Joint Disease using Percutaneously Implanted, Autologous Mesenchymal Stem Cells." Pain Physician 3;11, no. 5;3 (2008): 343–53. http://dx.doi.org/10.36076/ppj.2008/11/343.

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Background: The ability to repair tissue via percutaneous means may allow interventional pain physicians to manage a wide variety of diseases including peripheral joint injuries and osteoarthritis. This review will highlight the developments in cellular medicine that may soon permit interventional pain management physicians to treat a much wider variety of clinical conditions and highlight an interventional case study using these technologies Objective: To determine if isolated and expanded human autologous mesenchymal stem cells could effectively regenerate cartilage and meniscal tissue when

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Li, Siming, Xiaohong Yang, Zhencheng Feng, Pengzhen Wang, Weicong Zhu та Shuliang Cui. "Catalase Enhances Viability of Human Chondrocytes in Culture by Reducing Reactive Oxygen Species and Counteracting Tumor Necrosis Factor-α-Induced Apoptosis". Cellular Physiology and Biochemistry 49, № 6 (2018): 2427–42. http://dx.doi.org/10.1159/000493841.

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Background/Aims: Both physiologic remodeling and pathologic regeneration of cartilage tissue rely upon chondrocyte functions and are benefited from factors that promote viability and inhibit apoptosis of the cell, and associated mechanisms. High level of reactive oxygen species (ROS) and proinflammatory cytokines activate apoptosis signaling and initiate cell death, which can be attenuated by antioxidants. This study examined the effect of catalase (CAT) on ROS and tumor necrosis factor-α (TNF-α)-induced apoptosis in human C28/I2 chondrocytes cultured in monolayer. Methods: Chondrocytes were t

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Kim, Dong Hwan, Bo Young Kim, Dong Hyun Kim, Jin Hur, and Chung-Hwan Baek. "Rabbit palatum-derived mesenchymal progenitor cells tri-lineage differentiation on 2D substrates and 3D printed constructs." Journal of Applied Biomaterials & Functional Materials 17, no. 3 (2019): 228080001983452. http://dx.doi.org/10.1177/2280800019834520.

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Hard palate, developed by embryo neural crest stem cells, is a tissue with strong regenerative abilities. It is considered an abundant source of progenitor cells, forming various mesenchymal tissues. Rabbits are more suitable models than murine animals for regenerative preclinical study of the head and neck, owing to their larger size. However, there are no reports of the existence or characteristics of neural crest stem cells in the hard palate of rabbits. In this study, we demonstrate for the first time the presence of nestin-, Sox2-, and p75-positive neural crest stem cells obtained from th

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Jamnig, Angelika, and Günter Lepperdinger. "From tendon to nerve: an MSC for all seasons." Canadian Journal of Physiology and Pharmacology 90, no. 3 (2012): 295–306. http://dx.doi.org/10.1139/y11-109.

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The potential of mesenchymal stem cells (MSCs) to regenerate damaged tissue is well documented, as this specialized progenitor cell type exhibits superior cellular properties, and would allow medical as well as ethical limitations to be overcome. By now, MSCs have been successfully introduced in manifold experimental approaches within the newly defined realm of Regenerative Medicine. Advanced methods for in vitro cell expansion, defined induction of distinct differentiation processes, 3-dimensional culture on specific scaffold material, and tissue engineering approaches have been designed, and

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Taketani, Takeshi, Rie Kanai, Aya Mihara, et al. "Transplantation of Ex Vivo Expanded Allogeneic Mesenchymal Stem Cells with Bone Marrow Improved Osteogenesis and Bone Formation In Patients with Perinatal Hypophosphatasia." Blood 116, no. 21 (2010): 4690. http://dx.doi.org/10.1182/blood.v116.21.4690.4690.

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Abstract Abstract 4690 Hypophosphatasia (HPP) is one of the bone metabolic disorders caused by mutations of the liver/bone/kidney alkaline phosphatase (ALPL) gene encoding tissue-nonspecific alkaline phosphatase (ALP). The disease is characterized by the disturbance of bone and tooth mineralization and reduced serum ALP activity. Clinical severity of HPP often depends on the age of onset. Patients with perinatal and infantile forms usually have poor prognosis. Phenotype in patients with HPP is also closely related to residual enzyme activity affected by ALPL mutations. Most perinatal patients

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Dissertations / Theses on the topic "Ex vivo expanded cartilage cells"

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Guven, Hayrettin. "The therapeutic potential of ex vivo expanded natural killer (NK) cells for immunotherapy of cancer /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-564-X/.

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Sato, Kiyoshi. "Cytotoxic effects of γδ T cells expanded ex vivo by a third generation bisphosphonate for cancer immunotherapy". Kyoto University, 2007. http://hdl.handle.net/2433/135916.

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Ota, Tsuyoshi. "Administration of ex vivo-expanded bone marrow-derived endothelial progenitor cells attenuates focal cerebral ischemia-reperfusion injury in rats." Kyoto University, 2006. http://hdl.handle.net/2433/135643.

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Keith, Melinda Roskos. "The Contribution of Homeostatically Expanded Donor CD8 T Cells to Host Reconstitution Following Syngeneic Hematopoietic Cell Transplantation." Scholarly Repository, 2008. http://scholarlyrepository.miami.edu/oa_dissertations/134.

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During homeostatic expansion, peripheral T cells proliferate in response to lymphopenia, in the absence of cognate antigen or costimulatory signals. Host CD8 reconstitution following hematopoietic cell transplantation (HCT) involves the de novo-generation of T cells in addition to the homeostatic expansion of mature donor T cells present in the graft and donor lymphocyte infusion as well as host T cells that survive conditioning. Although it is well appreciated that CD8 homeostatic expansion contributes to host CD8 reconstitution following HCT, the factors governing the extent of the contribut

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Baylis, Oliver Jack. "The safety and efficacy of ex vivo expanded autologous limbal stem cells for the treatment of unilateral total limbal stem cell deficiency." Thesis, University of Newcastle upon Tyne, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.748549.

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The cornea is the clear window at the front of the eye, which allows light to focus onto the retina. The outer surface is covered in epithelial cells that are continually replaced by a population of stem cells located at the edge of the cornea termed the limbal stem cells. Limbal stem cell deficiency (LSCD) results in epithelial failure and conjunctival overgrowth, resulting in a painful, blinding disease. This condition can be treated by the transplantation of ex vivo expanded limbal stem cells from a donor eye in a technique originally described by Pellegrini et al. in 1997. Previously, a pr

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CHUANG, CHING-MIN, and 莊靜旻. "Ex Vivo Induction of Monocytes From Serum–Free Expanded Human Hematopoietic Stem Cells." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/58505275078513540746.

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碩士<br>元智大學<br>化學工程與材料科學學系<br>105<br>Hematopoietic stem cells (HSCs) are classified as adult stem cells with multiple differentiation abilities. After induction, HSCs can differentiate into various types of blood and immune cells, such as monocytes. The regulation of immune system is an important topic for pathology and oncology. In human immune system, monocytes were the type of first immune cell that was investigated in cell pathology. Monocytes have the ability to migrate rapidly to the injured or infected site of tissue in the early stage of inflammation, and show the association with many

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Windgassen, Dirk [Verfasser]. "Transcriptional analysis and characterization of ex vivo expanded T cells / vorgelegt von Dirk Windgassen." 2005. http://d-nb.info/974505862/34.

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Zysk, Aneta. "Adoptive transfer of ex vivo expanded gamma delta T cells targeting osteolytic cancer in the bone." Thesis, 2017. http://hdl.handle.net/2440/119272.

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Bone metastases occur in more than 75% of patients with advanced breast cancer. Cancer in bone is associated with bone destruction and is responsible for high levels of morbidity and mortality but is notoriously difficult to treat. Bone destruction is also the primary cause of morbidity in patients with primary bone cancer, such as osteosarcoma, with metastatic spread to the lungs correlating with poor survival. Therefore, clearly new therapies are desperately required to target cancers in the bone. This study explored the therapeutic potential of gamma delta (Vγ9Vδ2) T cell based adoptive tra

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Path, Jan Ragnar. "Untersuchungen an humanen chondrogenen Progenitorzellen aus späten Stadien der Osteoarthrose zu dem Migrationspotential und der Proliferationsfähigkeit ex vivo sowie zu den Auswirkungen einer Kultivierung in vitro auf das Genexpressionsmuster." Doctoral thesis, 2015. http://hdl.handle.net/11858/00-1735-0000-0022-5FE3-9.

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Diese Arbeit untersucht die humanen chondrogenen Progenitorzellen (CPC) auf ihre Eignung für einen möglichen Therapieansatz der Osteoarthrose (OA). Hierbei zeigte sich, dass die CPC die Fähigkeit zur Migration sowohl in vitro als auch ex vivo besitzen. In vitro steigerte der Einsatz von TGF-ß3 die Migrationsrate, was von therapeutischem Nutzen sein könnte. Die CPC wanderten ex vivo ebenso in Knorpelgewebe aus makroskopisch unauffälligen Bereichen wie in an den Hauptdefekt angrenzendes Gewebe ein. Mit der Versuchsdauer nahm die Einwanderungstiefe zu, wobei dies im unauffällig erscheinenden Knor

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Book chapters on the topic "Ex vivo expanded cartilage cells"

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Lu, Jingwei, Reeva Aggarwal, Vincent J. Pompili, and Hiranmoy Das. "Ex Vivo Expanded Hematopoietic Stem Cells for Ischemia." In Stem Cells and Cancer Stem Cells, Volume 2. Springer Netherlands, 2011. http://dx.doi.org/10.1007/978-94-007-2016-9_23.

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Maiti, Sourindra N. "Measurement of Average Telomere Length in Ex Vivo Expanded Natural Killer Cells by Fluorescence In Situ Hybridization (FISH) and Flow Cytometry." In Natural Killer Cells. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3684-7_5.

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Scheding, Stefan, Wolfram Brugger, and Lothar Kanz. "Transplantation of Ex-Vivo Expanded Peripheral Blood Progenitor Cells After High Dose Chemotherapy in Cancer Patients." In Bone Marrow Transplantation. Springer Japan, 1996. http://dx.doi.org/10.1007/978-4-431-68320-9_31.

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Bouchlaka, M. N., P. Hematti, and C. M. Capitini. "Therapeutic Purposes and Risks of Ex Vivo Expanded Mesenchymal Stem/Stromal Cells." In Mesenchymal Stromal Cells as Tumor Stromal Modulators. Elsevier, 2017. http://dx.doi.org/10.1016/b978-0-12-803102-5.00022-7.

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Goan, S. R., I. Junghahn, I. Fichtner, et al. "Ex vivo Expanded CD34+ Blood Progenitor Cells Display Lymphomyeloid plus Stromal Cell Differentiation Potential after Transplantation into NOD/SCID Mice." In Contributions to Oncology. S. Karger AG, 1999. http://dx.doi.org/10.1159/000425837.

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Conference papers on the topic "Ex vivo expanded cartilage cells"

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Hardwick, R. Alan, Bruce L. Levine, Carl H. June, et al. "Development of Closed Systems for Ex Vivo Cell Processing: Utility in Cell and Gene Therapy." In ASME 1997 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1997. http://dx.doi.org/10.1115/imece1997-1316.

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Abstract Two examples are described in which cells were processed in a closed sterile fluid path by using custom-designed instruments, plastic bags and tubing sets, and a sterile connection device. In the first example, nucleated blood cells were collected from HIV+ patients. These cells were enriched for CD4+ cells and the CD4+ cells were expanded in the presence of immobilized CD3 and CD28 antibodies. The cells were then concentrated, washed, and re-infused. For the largest batches this resulted in 2.20 × 1010 cells with 86% viability and a CD4+ cell purity ≥ 95%. In two out of three re-infu

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Olivares, Simon, Fiorela N. Hernandez, Wendong Zhang, Zhongting Zhang, Richard Gorlick та Harjeet Singh. "423 Effective targeting of osteosarcoma byex vivoexpanded TCR γδ T cells". У SITC 39th Annual Meeting (SITC 2024) Abstracts. BMJ Publishing Group Ltd, 2024. http://dx.doi.org/10.1136/jitc-2024-sitc2024.0423.

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Zoine, Jaquelyn T., Kathryn S. Sutton, Kristopher A. Knight, Kelly C. Goldsmith, Christopher B. Doering та H. Trent Spencer. "Abstract B42: The properties of ex vivo expanded γδ T cells provide for the rational use of combination therapies". У Abstracts: AACR Special Conference: Pediatric Cancer Research: From Basic Science to the Clinic; December 3-6, 2017; Atlanta, Georgia. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.pedca17-b42.

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Irving, Professor Peter, TRIBUTE Investigators, and Graham Lord. "P76 First in human treatment of crohn’s disease with autologous ex-vivo expanded, regulatory T-cells: initial results of the tribute feasibility study." In BSG LIVE’24, 17-20 June 2024, ICC Birmingham. BMJ Publishing Group Ltd and British Society of Gastroenterology, 2024. http://dx.doi.org/10.1136/gutjnl-2024-bsg.158.

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Ruggiero-Sherman, Alistaire D., Keene Lee, Xinyuan Liu, Imran A. Mohammad, and John B. Sunwoo. "389 Ex vivo expanded ieILC1-like NK cells induce significant tumor cell death and demonstrate metabolic flexibility and macrophage reprogramming capacity under hypoxic conditions." In SITC 39th Annual Meeting (SITC 2024) Abstracts. BMJ Publishing Group Ltd, 2024. http://dx.doi.org/10.1136/jitc-2024-sitc2024.0389.

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Hasan, Md Faqrul, Tayler Croom-Perez, Jeremiah Oyer, Thomas Dieffenthaller, Liza Robles-Carrillo, and Alicja Copik. "1009 Knockout of the inhibitory receptor TIGIT enhances anti-tumor response ofex vivoexpanded NK cells and prevents fratricide with therapeutic Fc-competent TIGIT antibodies." In SITC 37th Annual Meeting (SITC 2022) Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/jitc-2022-sitc2022.1009.

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Khatua, Soumen, Dean Lee, Laurence Cooper, et al. "Abstract CT216: Phase I study of intraventricular infusions of autologous ex vivo expanded NK cells in children with recurrent/refractory malignant posterior fossa tumors of the central nervous system." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-ct216.

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Khatua, Soumen, Dean Lee, Laurence Cooper, et al. "Abstract CT216: Phase I study of intraventricular infusions of autologous ex vivo expanded NK cells in children with recurrent/refractory malignant posterior fossa tumors of the central nervous system." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-ct216.

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Morelli, Maria Pia, Rafet Basar, David Marin, et al. "1457 Phase IB study of immunotherapy combining ex-vivo pre-activated and expanded cord blood NK cells with cetuximab in colorectal cancer patients with minimal residual disease: an interim report." In SITC 39th Annual Meeting (SITC 2024) Late Breaking Abstracts. BMJ Publishing Group Ltd, 2024. http://dx.doi.org/10.1136/jitc-2024-sitc2024.1457.

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Reports on the topic "Ex vivo expanded cartilage cells"

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Identification of Hazards in Meat Products Manufactured From Cultured Animal Cells. Food Standards Agency, 2023. http://dx.doi.org/10.46756/sci.fsa.crw572.

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Culturing of animal cells was developed in the late 19th and early 20th century, when researchers worked out how to support the growth of cells in media in an ex-vivo environment(footnote). The technology has been used commercially in the medical products industry, notably to produce antibodies for use as new medicines and as reagents in diagnostics. Animal cell culturing has expanded into the food industry especially due to its benefit in promoting sustainability for example by freeing up global arable land used for livestock farming, with cultured meat predicted to enter the UK market in the

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