Academic literature on the topic 'Extended-release tablet development and manufacturing'

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Journal articles on the topic "Extended-release tablet development and manufacturing"

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Chandra, Prakash Sunuwar* Meenakshi Kandwal Shivanand Patil. "A Review on Formulation and Evaluation of Mirabegron Extended-Release Tablets." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4859–65. https://doi.org/10.5281/zenodo.15547921.

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A type of modified-release dosage form known as an extended-release (ER) tablet is designed to release the active pharmaceutical ingredient (API) gradually over a long period of time. The human body metabolizes and excretes drugs at different rates. Fast drug absorption may result in peak plasma concentrations that could be harmful, whereas fast clearance in conventional formulations causes subtherapeutic levels that necessitate frequent dose. Extended-release formulations get around these issues and ensure a long-lasting therapeutic effect by modifying the kinetics of medicine release. This s
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Chandan, Singh* Dr. Rita Saini and Dr. Shivanand Patil. "A Process Development and Validation of Mirabegron Extended Release 25 Mg and Silodosin 8mg Bilayer Tablet." International Journal of Pharmaceutical Sciences 3, no. 6 (2025): 634–43. https://doi.org/10.5281/zenodo.15593321.

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Mirabegron & silodosin, is used often in combination as bilayer tablets, are primarily used to treat the symptoms of overactive bladder (OAB) & benign prostatic hyperplasia (BPH). Mirabegron drug helps to relax bladder muscles by increasing urine storage capacity and reduction in urine urgency. The drug Silodosin helps to relax the muscles in the prostate and bladder neck by improving urinary flow and reducing BPH-related symptoms.  The aim of the research study is to process validation (PV) of the formulation development of bilayer tablet of Mirabegron & silodosin drug. 
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Chandan, Singh* Rita Saini Shivanand Patil. "A Review of Bilayer Tablet Technology Immediate and Extended-Release Drug Delivery." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4491–503. https://doi.org/10.5281/zenodo.15534239.

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Compared to monotherapy (traditional dosage forms), combination therapy is more common and has several benefits.  The best and most recent example of mixed dose formulation is bilayer tablet technology. The pharmaceutical industry has seen a rise in single-dose formulation that combines 2 or 3 molecules within the tablets. By lowering the number of dosages and increasing the bioavailability of dosage forms, it is well known for encouraging patient convenience and compliance.  Innovative variations of traditional oral drug delivery technologies are bilayer or multilayer tablets. The o
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Alshetaili, Abdullah, Bjad K. Almutairy, Sultan M. Alshehri, and Michael A. Repka. "Development and Characterization of Sustained-Released Donepezil Hydrochloride Solid Dispersions Using Hot Melt Extrusion Technology." Pharmaceutics 13, no. 2 (2021): 213. http://dx.doi.org/10.3390/pharmaceutics13020213.

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The aim of this work was to develop the sustained release formulation of donepezil hydrochloride (DH) using the hot-melt extruded solid dispersion technique via the rational screening of hydrophobic carriers. Hydrophobic carriers with different physicochemical properties such as pH-independent swellability, low-permeability (Eudragit® RS PO (E-RS)), pH-independent non-swellability (ethyl cellulose N7 (EC-N7)), and the presence of lipids (Compritol® 888 ATO (C-888)) with or without pore-forming agents were used to achieve the sustained release profile of DH. Mannitol (MNT) was chosen as the tem
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Gangurde, Gayatri* Dhum Manohar Gavali Prashant Sonawane Mitesh. "Review on Bilayer Tablets." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 1192–203. https://doi.org/10.5281/zenodo.15019244.

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Bi-layer tablets are essential for developing both immediate and modified drug delivery systems for various diseases. They facilitate controlled medication release, representing a significant advancement in Controlled Drug Delivery Systems (CDDS) and improving the effectiveness of medication delivery. Over the past 30 years, the complexity and costs of introducing new drugs have increased, leading to greater focus on sustained or controlled release systems. Bi-layer tablets enable precise delivery of medications with predetermined release profiles, preventing chemical incompatibilities between
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Prof., Madhuri T. Deshmukh Ganesh Deokate *. Prof. R.V. Shete. "A REVIEW ON BILAYER TECHNOLOGY." Journal of Pharma Research 8, no. 3 (2019): 81–87. https://doi.org/10.5281/zenodo.2620324.

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<strong><em>ABSTRACT</em></strong> <strong><em>O</em></strong><em>ver the past 30 years, the expenses and complications involved in marketing new drug entities have increased with concomitant recognition of therapeutic advantages of controlled drug delivery. Now a days greater attention has been focused on development of controlled &amp; immediate release drug delivery systems. Bi-layer tablet is suitable for sequential release of two drugs in combination and also for sustained release of tablet in which one layer is for immediate release as loading dose and second layer is maintenance dose. S
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Coutinho, Ana Luisa, Asmita Adhikari, and James Polli. "10122 Development of an In Vitro in Vivo Correlation of Itraconazole Spray-Dried Dispersion Tablets." Journal of Clinical and Translational Science 5, s1 (2021): 96–97. http://dx.doi.org/10.1017/cts.2021.649.

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ABSTRACT IMPACT: As the number of poorly water-soluble drugs in development increases, our research will expand on the science behind improving drug solubility and absorption and ensuring that promising poorly-water solubility drugs do not fail drug development. OBJECTIVES/GOALS: Spray-dried dispersion (SDD) tablet formulation is an approach to increase oral drug solubility and absorption. Methods to predict SDD performance in humans are poorly developed. We aim to develop an in vivo in vitro correlation (IVIVC) between in vitro dissolution and in vivo absorption of itraconazole SDD tablets. M
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K, Kulkarni, and Deokar G. "From Challenges to Advancement for Bilayer Tablet Technology as Drug Delivery System." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 04 (2024): 1676–82. https://doi.org/10.25258/ijddt.14.4.64.

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Bilayer tablet technology is in focus because it advantageous for combination therapy, for combining two different release profile and it gives patent novelty to existing dosage. Hence its advantages, challenges and applications need to be discuss. The objective of preparing a review article on bilayer tablets is multifaceted, aiming to cover challenges at formulation development to scaleup and opportunity for new product development by integrating it bilayer tablet technology with other formulation technology. With reference to all the electronic data it was found that bilayer tablets face ma
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Jain, Priyanshi, ,. Ekta, R. S. Kushwaha, and Azaz Khan. "Formulation and Evaluation of Sustained Release Matrix Tablets of Isoxsuprine Hydrochloride by Direct Compression Method." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 80–85. http://dx.doi.org/10.22270/jddt.v9i3-s.2797.

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A sustained-release tablet formulation should ideally have a proper release profile insensitive to moderate changes in tablet hardness that is usually encountered in manufacturing. Isoxsuprine hydrochloride is structurally a novel vasodilator. The short biological half-life (5±2 hr) and the fast clearance make the drug, a suitable candidate for the development of modified release formulation. A novel oral controlled delivery system for isoxsuprine hydrochloride was developed and optimized. Matrix tablets of isoxsuprine hydrochloride were prepared by using hydroxypropylmethylcellulose (HPMC K15
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Sadhana, Shahi, B. Barkate Manoj, A. Shete Nikita, and N. Bobade Manjari. "A Review on Multi-layered Tablets: A way to control the drug release." AMERICAN JOURNAL OF PHARMACY AND HEALTH RESEARCH 11, no. 01 (2023): 1–18. https://doi.org/10.5281/zenodo.7807820.

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ABSTRACT Due to necessities their affordable manufacturing costs and simplicity of administration, especially in controlled-release applications, tablet dosage forms have traditionally been chosen over other formulations for oral medication delivery. Over monotherapy, combination therapy has a number of benefits. The pharmaceutical industry has grown more interested in recent years in creating dosage forms (monolithic, bilayer, or multi-layered tablets) that combine two or more Active Pharmaceutical Ingredients (API), improving patient convenience and compliance. The active pharmaceutical ingr
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Dissertations / Theses on the topic "Extended-release tablet development and manufacturing"

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TILLOTSON, JOHN KING. "DEVELOPMENT AND EVALUATION OF EXTENDED-RELEASE BUMETANIDE TABLETS." University of Cincinnati / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1085067185.

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Book chapters on the topic "Extended-release tablet development and manufacturing"

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Sunitha, Ramineni, Praveen Sivadasu, and Raghavendra Kumar Gund. "Statistical Optimization and Evaluation of Extended Release Tablets for Divalproex Sodium." In Current Trends in Drug Discovery, Development and Delivery (CTD4-2022). Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/9781837671090-00549.

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The purpose of current experimental research is to optimize the quantities of macromolecules such as EudragitL/100-55, HPMC-K-100M for the development of divalproex sodium extended release tablets. Divalproexsodium, an anticonvulsant or epileptic agent. It was used in the effective management of bipolar disorders, Mania, seizures, convulsions, tremors/epilepsy. Divalproex sodium ER tablets were formulated with the help of EudragitL/100-55 and HPMC-K-100M in variable composition and variable amounts as per 32 factorial design technique. They were prepared by direct compression technique. Quanti
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Conference papers on the topic "Extended-release tablet development and manufacturing"

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Zambrano, Consuelo Del Pilar Vega, Nikolaos A. Diangelakis, and Vassilis M. Charitopoulos. "Closed-Loop Data-Driven Model Predictive Control For A Wet Granulation Process Of Continuous Pharmaceutical Tablet Production." In The 35th European Symposium on Computer Aided Process Engineering. PSE Press, 2025. https://doi.org/10.69997/sct.192802.

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In 2023, the International Council for Harmonisation (ICH) guideline for the development, implementation, and lifecycle management of pharmaceutical continuous manufacturing (PCM), was implemented in Europe. It promotes quality-by-design (QbD) and quality by control (QbC) strategies as well as the appropriate use of mathematical modelling. This development urges a harmonizing understanding across academia and industry for adoption of interpretable models instead of black-box models for advanced control strategies such as model predictive control (MPC), especially when applied in Good Manufactu
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Chadha, Bipin, R. E. Fulton, and J. C. Calhoun. "Case Study Approach for Information-Integration of Material Handling." In ASME 1991 International Computers in Engineering Conference and Exposition. American Society of Mechanical Engineers, 1991. http://dx.doi.org/10.1115/edm1991-0178.

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Abstract Information-Integration is vital for keeping manufacturing operations competitive. A case study approach has been adopted to better understand the role of information in integrated manufacturing. Information is now considered a corporate asset. Creation, processing, movement, and security of information is therefore as important as that of the products/services of an enterprise. The case studies have helped in identifying the issues involved in developing an information system and supporting software framework for a manufacturing enterprise. The case studies have helped in refining an
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Ira, Martha Mead. "Process Safety Management and Risk Management Program (PSM/RMP) Audits: Are You Prepared?" In ASME 2003 Citrus Engineering Conference. American Society of Mechanical Engineers, 2003. http://dx.doi.org/10.1115/cec2003-4903.

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In June 1996, the Environmental Protection Agency (EPA) promulgated 40 CFR Part 68, Accidental Release Prevention Requirements: Risk Management Programs (RMP) Under Clean Air Act, Section 112 r (7), commonly called the RMP rule. Much of the RMP rule was already required by the Occupational Safety and Health Administration’s (OSHA) 29 CFR 1910.119 Process Safety Management of Highly Hazardous Chemicals (the PSM Standard), which had been issued four years earlier. Because both of these regulations include anhydrous ammonia at a threshold level of 10,000 lbs., many refrigerated warehousing and ma
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Borges Farconi, Leonardo, and Matias Bestard Körner. "Methods and Procedure for the nonlinear dynamic characterization of Inertial Sensors under diverse operational conditions." In ESA 12th International Conference on Guidance Navigation and Control and 9th International Conference on Astrodynamics Tools and Techniques. ESA, 2023. http://dx.doi.org/10.5270/esa-gnc-icatt-2023-062.

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Gyroscopes and accelerometers are sensors of ultimate importance in Inertial Navigation Systems (INS), where the rate and acceleration readings are cumulated to estimate the current attitude and position of a system. The errors in those readings therefore degrade the attitude and position estimates with time. With the purpose of reducing those errors inertial sensors have been characterized in laboratories to better model and compensate the errors by means of calibrations in the respective navigation filters or to simulate them for performance analysis. Historically, these errors have been red
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