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Relevant bibliographies by topics / Fibroblast formation

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Academic literature on the topic 'Fibroblast formation'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Fibroblast formation"

1

Heng, Madalene. "Phosphorylase Kinase Inhibition Therapy in Burns and Scalds." BioDiscovery 20 (February 24, 2017): e11207. https://doi.org/10.3897/biodiscovery.20.e11207.

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Severe burns and scalds almost always result in unsightly hypertrophic scarring. Among the important processes involved in scarring are fibroblast formation and transformation of fibroblasts into myofibroblasts. Myofibroblasts contain α-smooth muscle actin which has contractile properties and can lead to wound contraction and hypertrophic scarring. Phosphorylase kinase (PhK), expressed within 5 mins of injury, is among the earliest enzymes released after tissue damage. It is responsible for activation of NF-kB, which in turn activates over 200 different genes related to inflammation, fibroblas

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Lebel, Mégane, Dominic O. Cliche, Martine Charbonneau, et al. "Invadosome Formation by Lung Fibroblasts in Idiopathic Pulmonary Fibrosis." International Journal of Molecular Sciences 24, no. 1 (2022): 499. http://dx.doi.org/10.3390/ijms24010499.

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Idiopathic pulmonary fibrosis (IPF) is characterized by abnormal fibroblast accumulation in the lung leading to extracellular matrix deposition and remodeling that compromise lung function. However, the mechanisms of interstitial invasion and remodeling by lung fibroblasts remain poorly understood. The invadosomes, initially described in cancer cells, consist of actin-based adhesive structures that coordinate with numerous other proteins to form a membrane protrusion capable of degrading the extracellular matrix to promote their invasive phenotype. In this regard, we hypothesized that invadoso

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Qian, Huan, Yihan Shan, Ruicheng Gong, et al. "Fibroblasts in Scar Formation: Biology and Clinical Translation." Oxidative Medicine and Cellular Longevity 2022 (May 12, 2022): 1–11. http://dx.doi.org/10.1155/2022/4586569.

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Scarring, which develops due to fibroblast activation and excessive extracellular matrix deposition, can cause physical, psychological, and cosmetic problems. Fibroblasts are the main type of connective tissue cells and play important roles in wound healing. However, the underlying mechanisms of fibroblast in reaching scarless wound healing require more exploration. Herein, we systematically reviewed how fibroblasts behave in response to skin injuries, as well as their functions in regeneration and scar formation. Several biocompatible materials, including hydrogels and nanoparticles, were als

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Cai, Zhou, Hua Guo, Jing Qian та ін. "Effects of bone morphogenetic protein 4 on TGF-β1-induced cell proliferation, apoptosis, activation and differentiation in mouse lung fibroblasts via ERK/p38 MAPK signaling pathway". PeerJ 10 (27 липня 2022): e13775. http://dx.doi.org/10.7717/peerj.13775.

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Fibroblasts, in particular myofibroblasts, are the critical effector cells in idiopathic pulmonary fibrosis (IPF), a deadly lung disease characterized by abnormal lung remodeling and the formation of “fibroblastic foci”. Aberrant activation of TGF-β1 is frequently encountered and promotes fibroblast proliferation, activation, and differentiation in pulmonary fibrosis. Hence, the inhibition of TGF-β1-induced lung fibroblast activation holds promise as a therapeutic strategy for IPF. The present study aimed to investigate the potential effect and underlying mechanisms of bone morphogenetic prote

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Koo, Kyo-in, Andreas Lenshof, Le Thi Huong, and Thomas Laurell. "Acoustic Cell Patterning in Hydrogel for Three-Dimensional Cell Network Formation." Micromachines 12, no. 1 (2020): 3. http://dx.doi.org/10.3390/mi12010003.

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In the field of engineered organ and drug development, three-dimensional network-structured tissue has been a long-sought goal. This paper presents a direct hydrogel extrusion process exposed to an ultrasound standing wave that aligns fibroblast cells to form a network structure. The frequency-shifted (2 MHz to 4 MHz) ultrasound actuation of a 400-micrometer square-shaped glass capillary that was continuously perfused by fibroblast cells suspended in sodium alginate generated a hydrogel string, with the fibroblasts aligned in single or quadruple streams. In the transition from the one-cell str

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Kohlhauser, Michael, Marcel Mayrhofer, Lars-Peter Kamolz, and Christian Smolle. "An Update on Molecular Mechanisms of Scarring—A Narrative Review." International Journal of Molecular Sciences 25, no. 21 (2024): 11579. http://dx.doi.org/10.3390/ijms252111579.

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Fibroblasts, the principal cellular mediators of connective tissue remodeling, play a crucial role in the formation of physiological and pathological scars. Understanding the intricate interplay between fibroblasts and other cellular and molecular components is essential for elucidating the underlying mechanisms driving scar formation. Hypertrophic scars, keloids and atrophic scars arise from dysregulated wound healing processes characterized by persistent inflammation, aberrant collagen deposition, and impaired extracellular matrix remodeling. Fibroblasts play a central role in the pathogenes

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Newman, Andrew C., Martin N. Nakatsu, Wayne Chou, Paul D. Gershon, and Christopher C. W. Hughes. "The requirement for fibroblasts in angiogenesis: fibroblast-derived matrix proteins are essential for endothelial cell lumen formation." Molecular Biology of the Cell 22, no. 20 (2011): 3791–800. http://dx.doi.org/10.1091/mbc.e11-05-0393.

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A role for fibroblasts in physiological and pathological angiogenesis is now well recognized; however, the precise mechanisms underlying their action have not been determined. Using an in vitro angiogenesis model in combination with a candidate gene approach, column chromatography, and mass spectrometry, we identify two classes of fibroblast-derived factors—one that supports vessel sprouting but not lumen formation, and one that promotes lumen formation. In the absence of fibroblasts a combination of angiopoietin-1, angiogenin, hepatocyte growth factor, transforming growth factor-α, and tumor

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Yoon, Dajeong, Dogeon Yoon, Heejoong Sim, Inseok Hwang, Ji-Seon Lee, and Wook Chun. "Accelerated Wound Healing by Fibroblasts Differentiated from Human Embryonic Stem Cell-Derived Mesenchymal Stem Cells in a Pressure Ulcer Animal Model." Stem Cells International 2018 (December 30, 2018): 1–12. http://dx.doi.org/10.1155/2018/4789568.

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Fibroblasts synthesize and secrete dermal collagen, matrix proteins, growth factors, and cytokines. These characteristics of fibroblasts provide a potential way for fibroblast therapy to treat skin ulcers more effectively than conventional therapies such as cytokine therapy and negative pressure wound therapy. However, the obstacle to the commercialization of fibroblast therapy is the limited supply of cells with consistent quality. In this study, we tested whether human embryonic stem cell-derived mesenchymal stem cells (hESC-MSCs) could be differentiated into fibroblasts considering that the

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Srinivasan, Suseela, Jennifer Strange, Feyisola Awonusonu, and Margaret C. Bruce. "Insulin-like growth factor I receptor is downregulated after alveolarization in an apoptotic fibroblast subset." American Journal of Physiology-Lung Cellular and Molecular Physiology 282, no. 3 (2002): L457—L467. http://dx.doi.org/10.1152/ajplung.00050.2001.

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After alveolar formation, >20% of interstitial lung fibroblasts undergo apoptosis, a process that is of critical importance for normal lung maturation. The immature lung contains two morphologically distinct fibroblast populations, lipid-filled interstitial fibroblasts (LIF) and non-LIF (NLIF), which differ with respect to contractile protein content, proliferative capacity, and expression of mRNAs for fibronectin and types I and III collagen, but not tropoelastin. After alveolarization, apoptosis occurs in only one fibroblast population, the LIF. Using flow cytometry to analyze fibroblasts

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Volin, Michael, Brian Zanotti, Karolina Klosowska, et al. "Rheumatoid arthritis synovial tissue fibroblast Mucin 3 expression and function (54.27)." Journal of Immunology 188, no. 1_Supplement (2012): 54.27. http://dx.doi.org/10.4049/jimmunol.188.supp.54.27.

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Abstract Mucin 3 (MUC3) is elevated in rheumatoid arthritis (RA) synovial tissues (STs). We hypothesized that MUC3 is expressed by RA synovial fibroblasts, that it is cytokine inducible and chemotactic for RA synovial fibroblasts. To test this, RA synovial fibroblast MUC3 expression was determined by immunohistochemistry, flow cytometry and Western blot analysis. Levels of MUC3 from arthritic synovial fluids (SFs) were measured by a novel MUC3 ELISA. RA synovial fibroblast chemotaxis to RA SFs was assessed using a modified Boyden chamber assay. RA ST cells stained for both MUC3 and vimentin in

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Dissertations / Theses on the topic "Fibroblast formation"

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Skelly, R. T. "The contribution of fibroblast phenotype to stricture formation in Crohn's disease." Thesis, Queen's University Belfast, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398093.

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Daley, Sandra J. "Basic fibroblast growth factor mediates neointimal formation in porcine aortic explants." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ27902.pdf.

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Davies, Paul Andrew. "Studies on the regulation of marrow fibroblast colony formation and differentiation." Thesis, University of Sheffield, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364241.

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Gallego-Llamas, Jabier. "Retinoic acid and Fibroblast Growth Factors during segmentation and somite formation." Université Louis Pasteur (Strasbourg) (1971-2008), 2007. http://www.theses.fr/2007STR13249.

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Au cours de la somitogénèse, l’action combinée d’un oscillateur moléculaire et la progression d’un front de détermination conduit à la formation périodique et synchronisée des somites. La régulation de la somitogénèse est sous le contrôle de plusieurs voies de signalisation dont les voies Notch, Wnt et Fgf. Récemment nous avons montré l’importance de l’acide rétinoïque (AR) dans cette cascade pour le positionnement correct des frontières somitiques de la synchronisation gauche/droite des oscillations moléculaires. L’asymétrie induite par la déficience en AR semble entre autre passer par la rég

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Manrique, Zuñiga Santiago. "Structural and computational studies of fibroblast growth factor receptor signalling complex formation." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:b6ccd433-f59b-40e6-838e-70aec5553caf.

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Fibroblast growth factor receptor (FGFR) signalling plays a crucial role in embryogenesis, adult tissue development and tissue repair. It has been implicated in a wide range of human pathologies such as cancers and skeletal disorders which is the reason for a particular interest over recent years. Concerted efforts in academia and industry are targeting the FGFR signalling networks at different stages. The intracellular canonical downstream signalling pathways in healthy and pathogenic cells are relatively well understood. A definition of the precise mechanism for ligand induced FGFR dimerisat

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Hamade, Fares. "Enhanced bone formation during distraction osteogenesis in FGFR3 deficient mice." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112630.

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Distraction Osteogenesis (DO) is a technique for bone lengthening and filling of bone defects following trauma, infection or resection of tumors. DO consists of an osteotomy of the bone to be lengthened, followed by controlled distraction of the bone segments with an external fixator until the desired lengthening is obtained (distraction phase). This is followed by the consolidation phase, during which the external fixator is kept in place until the newly formed bone in the distracted zone consolidates. This phase is long and may cause numerous problems. Ongoing research aims at finding a meth

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Mohammed, T. "Evaluating the effects of acoustic stimulation on fibroblast cell migration and muscle fibre formation." Thesis, Liverpool John Moores University, 2017. http://researchonline.ljmu.ac.uk/6047/.

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Cells are known to interact and respond to external mechanical cues and recent work has shown that application of mechanical stimulation, delivered via acoustic vibration, can be used to control complex cell behaviours. Much of the work in this area has focused on the effects of mechanical stimulation upon bone cells. Very little has been done to investigate the effects of mechanical stimulation on other cell types. Therefore, could mechanical stimulation be used to accelerate the wound healing process? Could mechanical stimulation be used to encourage muscle cell growth? The data generated in

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Mseka, T. "Behaviour, formation and function of oriented actin filament bundles in the establishment of fibroblast polarity." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1318097/.

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To establish morphological polarity, a cell must form a rear that is distinct from its front. For subsequent directional migration it must continuously retract its rear and protrude its front, polarised in the direction of migration. Here, two methods for the analysis of the transition from a pre-polar to a polarised state are used; spontaneous and cue dependant polarisation. Time-lapse microscopy of primary chick embryo heart fibroblasts expressing GFP-actin showed that, prior to cell polarization, actin filament bundles in the cell body reorganise to form oriented filament bundles spanning t

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Marui, Akira. "Simultaneous application of basic fibroblast growth factor and hepatocyte growth factor to enhance the blood vessels formation." Kyoto University, 2005. http://hdl.handle.net/2433/144737.

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Albishi, Waleed. "Inhibition of fibroblast growth factor receptor 3 (FGFR3) signalling to accelerate bone formation during distraction osteogenesis of mice tibiae." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=121465.

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Distraction osteogenesis (DO) is a surgical technique widely used for the treatment of limb length discrepancies, limb deformities, long bone nonunions, and bone loss. The technique involves performing an osteotomy and then gradually distracting the two bone segments with an external fixator. This generates new bone within the distracted gap. Although very successful, one of the limitations of this technique is the long period of time the external fixator needs to be kept on, until the newly formed bone in the distracted zone consolidates. This prolonged process may lead to numerous social, ps

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Books on the topic "Fibroblast formation"

1

Daley, Sandra J. Basic fibroblast growth factor mediates neointimal formation in porcine aortic explants. National Library of Canada = Bibliothèque nationale du Canada, 1997.

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2

Matsui, Mary Steidl. Fatty-acid induced modification of mouse embryo fibroblast C3H 10T1/2 cells: Lipid composition, benzo[a]pyrene metabolism and DNA adduct formation, malignant transformation, and phorbol ester binding. 1986.

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Duman, Ronald S. Neurotrophic Mechanisms of Depression. Edited by Dennis S. Charney, Eric J. Nestler, Pamela Sklar, and Joseph D. Buxbaum. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190681425.003.0027.

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Early theories of depression and treatment response were centered on the monoamine neurotransmitters, but more recent work has focused on functional and structural synaptic plasticity and the role of neurotrophic factors, particularly brain derived neurotrophic factor (BDNF). Neurotrophic factors regulate all aspects of neuronal function, including adaptive plasticity, synapse formation, and neuronal survival. Chronic stress and depression cause reductions in levels of BDNF and other key factors, including vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF2), in cort

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Turner, Neil. Crescentic (rapidly progressive) glomerulonephritis. Edited by Neil Turner. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0070.

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Crescent formation refers to the appearance of proliferating cells in Bowman’s space in response to severe glomerular inflammation. Any aggressive ‘nephritic’ diseases that cause basement membrane breaks may provoke this. Specific serum proteins appear to be responsible for provoking crescent formation as it is largely abolished by defibrination in animal models. The cells in the crescent are initially mostly hypertrophying and proliferating parietal epithelial cells that normally line Bowman’s capsule. Foci of proliferation of these cells (extracapillary proliferation) are the first steps of

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Sprague, Stuart M., and James M. Pullman. Spectrum of bone pathologies in chronic kidney disease. Edited by David J. Goldsmith. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0122.

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Histologic bone abnormalities begin very early in the course of chronic kidney disease. The KDIGO guidelines recommend that bone disease in patients with chronic kidney disease should be diagnosed on the basis of bone biopsy examination, with bone histomorphometry. They have also proposed a new classification system (TMV), using three key features of bone histology—turnover, mineralization, and volume—to describe bone disease in these patients. However, bone biopsy is still rarely performed today, as it involves an invasive procedure and highly specialized laboratory techniques. High-turnover

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Crawshaw, Anjali. Sarcoidosis and other granulomatous lung disease. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0138.

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Sarcoidosis is a multisystem disorder characterized by the formation of non-caseating granulomas in many tissues. A granuloma is an organized aggregate of immune cells; it forms in response to an antigenic stimulus. It contains abnormal macrophages (epithelioid histiocytes, which often fuse to form multinucleated giant cells), lymphocytes, neutrophils, eosinophils, fibroblasts, and collagen.

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Covic, Adrian, Mugurel Apetrii, Luminita Voroneanu, and David J. Goldsmith. Vascular calcification. Edited by David J. Goldsmith. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0120_update_001.

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Vascular calcification (VC) is a common feature of patients with advanced CKD and it could be, at least in part, the cause of increased cardiovascular mortality in these patients. From a morphologic point of view, there are at least two types of pathologic calcium phosphate deposition in the arterial wall—namely, intima calcification (mostly associated with atherosclerotic plaques) and media calcification (associated with stiffening of the vasculature, resulting in significantly adverse cardiovascular outcomes). Although VC was viewed initially as a passive phenomenon, it appears to be a cell-

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Reader, Jocelyn, Sarah Lynam, Amy Harper, Gautam Rao, Maya Matheny, and Dana M. Roque. Ovarian Tumor Microenvironment and Innate Immune Recognition. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190248208.003.0004.

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Ovarian adenocarcinoma is typified by detection at late stages with dissemination of cancer cells into the peritoneal cavity and frequent acquisition of chemoresistance. A number of studies show the importance of the tumor microenvironment and innate immune recognition in tumor progression. Ovarian cancer cells can regulate the composition of their stroma to promote the formation of ascitic fluid rich in cytokines and bioactive lipids such as PGE2, and to stimulate the differentiation of stromal cells into a pro-tumoral phenotype. In response, cancer-associated fibroblasts, cancer-associated m

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Book chapters on the topic "Fibroblast formation"

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Nerede, Helin, and Menduh Oruc. "Aspiration Pneumonia in Children." In Pediatric Chest Infection. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053359463.14.

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Idiopathic pulmonary fibrosis is characterized by an aberrant wound healing response following lung injury, leading to excessive fibroblast proliferation and extracellular matrix deposition. Fibroblasts and myofibroblasts play a central role in the disease process. They proliferate abnormally and produce collagen and other matrix proteins, resulting in fibrosis. Epithelial-mesenchymal transition where epithelial cells transform into mesenchymal cells, contributes to the pool of fibroblasts in the fibrotic lung. Mutations in genes related to telomere maintenance (TERT, TERC) and surfactant prot

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Olcay, Mahmut. "Viral Pneumonia in Children." In Pediatric Chest Infection. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053359463.15.

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Abnormal wound healing of idiopathic pulmonary fibrosis is characterized by an inappropriate wound healing response following lung injury, leading to excessive proliferation of fibroblasts and deposition of extracellular matrix proteins. Fibroblasts and myofibroblasts are central players in the fibrotic process, these cells proliferate and produce large amounts of collagen and other matrix components, contributing to the stiffening of lung tissue. Epithelial-mesenchymal transition of epithelial cells transform into mesenchymal cells, adding to the fibroblast population and promoting fibrosis.

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Sugi, Yukiko, Naoki Ito, Gyorgyi Szebenyi, John F. Fallon, Takashi Mikawa, and Roge R. Markwald. "Role of Fibroblast Growth Factors in Early Valve Leaflet Formation." In Cardiovascular Development and Congenital Malformations. Blackwell Publishing Ltd, 2007. http://dx.doi.org/10.1002/9780470988664.ch16.

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Kato, Yukio. "Roles of Fibroblast Growth Factor and Transforming Growth Factor-β Families in Cartilage Formation." In Biological Regulation of the Chondrocytes. Routledge, 2022. http://dx.doi.org/10.1201/9781315138329-5.

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Kerkis, A. Ju. "An Electron Microscopic Study of the Structural Mechanisms of Hybrid Nucleus Formation During Spontaneous Splenocyte-Fibroblast Fusion." In Nuclear Structure and Function. Springer US, 1990. http://dx.doi.org/10.1007/978-1-4613-0667-2_100.

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Darby, Ian A., and Alexis Desmoulière. "Scar Formation: Cellular Mechanisms." In Textbook on Scar Management. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-44766-3_3.

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AbstractFibroblasts are key players in the maintenance of skin homeostasis and in orchestrating physiological tissue repair. Fibroblasts secrete and are embedded in a sophisticated extracellular matrix, and a complex and interactive dialogue exists between fibroblasts and their microenvironment. In addition to the secretion of the extracellular matrix, fibroblasts and myofibroblasts secrete extracellular matrix remodeling enzymes, matrix metalloproteinases and their inhibitors, and tissue inhibitors of metalloproteinases and are thus able to remodel the extracellular matrix. Myofibroblasts and

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Shimura, Tsutomu. "Roles of Fibroblasts in Microenvironment Formation Associated with Radiation-Induced Cancer." In Advances in Experimental Medicine and Biology. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-73119-9_13.

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Choi, C. H., B. I. Kim, H. K. Kwon, and Suck Jin Hong. "Effects of Herbal Extracts on Dental Plaque Formation and Human Gingival Fibroblasts." In Advanced Biomaterials VII. Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-436-7.773.

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Sadiq, Alia, Nonhlanhla P. Khumalo, and Ardeshir Bayat. "Genetics of Keloid Scarring." In Textbook on Scar Management. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-44766-3_8.

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AbstractKeloid disease is a benign fibro-proliferative reticular dermal tumor that develops in response to dysregulated cutaneous wound-healing process. The key alterations result in keloid formation have not been fully understood yet.Extensive literature review suggests that there is a strong genetic predisposition for keloid formation as keloid cases have appeared in twins, families, Asian and African descendant ethnic groups predominantly. Thus, there have been several attempts to investigate the genetic variations that may act as contributing factors in keloid pathogenesis, but no single g

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Gürdal, Mehmet, Gülinnaz Ercan, and Dimitrios I. Zeugolis. "Formation of Corneal Stromal-Like Assemblies Using Human Corneal Fibroblasts and Macromolecular Crowding." In Methods in Molecular Biology. Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0599-8_9.

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Conference papers on the topic "Fibroblast formation"

1

Hurley, Jennifer R., and Daria A. Narmoneva. "Fibroblasts Induce Mechanical Changes in the Extracellular Environment and Enhance Capillary-Like Network Formation." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-193093.

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Cardiac tissue engineering studies have demonstrated the importance of revascularization in engineered grafts for successful implantation and regeneration [1]. Understanding the myocardium’s complex cellular organization and the interactions between the major cardiac cell types (cardiomyocytes, endothelial cells, and cardiac fibroblasts) is critical for revascularization. Our previous studies have shown the importance of cardiomyocyte-endothelial interactions [2]. However, there is limited information available on endothelial-fibroblast interactions. We and others have previously observed that

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Schiele, Nathan R., Douglas B. Chrisey, and David T. Corr. "Proliferation and Fiber Formation of Human Dermal Fibroblasts on Patterned Differentially Adherent Substrates." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192910.

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Fibroblast cells are crucial in the human body for maintenance of the extracellular matrix, including synthesizing macromolecules like collagen, and they play a critical role in wound healing of soft tissues such as skin [1]. Directing fibroblast growth is an important step in tissue engineering where the focus has gone from a top-down approach of homogeneously introducing cells into a pre-formed scaffold to a bottom-up approach in which the tissue construct is built on a cell-by-cell basis with ability to manipulate specific cell environments through location, proximity, and geometry. The abi

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Ruder, Warren C., Erica D. Pratt, Metin Sitti, Philip R. LeDuc, and James F. Antaki. "Investigation of Calcium Mechanotransduction by Quasi 3-D Microfiber Mechanical Stimulation of Cells." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192913.

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Fibroblast cells mechanically interact with their environment through several mechanisms, including the formation of focal adhesion complexes (FACs) with adjacent ligands. A quasi-3D (Q3D) experimental device was devised to investigate chemo-mechanical stimulation of these cells. It employed a novel microscopic fixture featuring micropolymer arrays positioned just above a cellular monolayer, enabling mechanical stimulation through dorsal attachment to FACs. This protocol demonstrated the ability to preserve the normal stellate morphology of fibroblasts. Live-cell imaging during mechanical stim

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Freyman, Toby M., Ioannis V. Yannas, Yuri-Shona Pek, Rayka Yokoo, and Lorna J. Gibson. "Micromechanics of Fibroblast Contraction of a Collagen-Gag Matrix." In ASME 2001 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2001. http://dx.doi.org/10.1115/imece2001/bed-23150.

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Abstract Contractile fibroblasts play a major role in the synthesis and remodeling of scar tissue following dermal injury. Inhibition of dermal wound contraction by contractile fibroblasts, using a collagen-GAG matrix, has been linked to the blocking of scar formation[1]. Scar tissue is mechanically and functionally inferior to the dermal tissue which it replaces. Specifically, scar tissue is weaker, physically disfiguring, and can lead to restricted joint mobility.

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Ciminieri, C., M. Woest, N. L. Reynaert та ін. "IL-1β Induces a Pro-Inflammatory Fibroblast Micro-Environment That Impairs Alveolar Epithelial Organoid Formation". У American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a5585.

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Baker, J. B., M. P. McGrogan, C. Simonsen, R. L. Gronke, and B. W. Festoff. "STRUCTURE AND PROPERTIES OF PROTEASE NEXIN I." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644765.

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Human foreskin fibroblasts secrete several different serine protease inhibitors which differ in size and protease specificities. These proteins, called protease nexins (PNs) all form SDS-resistant complexes with their protease targets. Fibroblast surface receptors recognize the protease-PN complexes and mediate their delivery to lysosomes. PNI is a 45 kilodalton glycoprotein that rapidly inhibits several arg or lys-specific proteases including trypsin, thrombin, and urokinase (k assoc.∼ 4×l06,∼ 6×105 and ∼ 2×105, m−1s−1 respectively). Like antithrombin III, PNI binds heparin and inhibits throm

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Muszbek, L., R. Adåny, M. A. Glukhova, M. G. Frid, A. E. Kabakov, and V. E. Kot-e-liansky. "THE IDENTIFICATION OF VIMENTIN, AN INTERMEDIATE,FILAMENT SUBUNIT PROTEIN IN HUMAN PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643900.

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Abstract:

In platelets the presence of basic subunit proteins of microtubules as well as microfilaments has been verified a long time ago and it was also shown that both of these cytoskeletal systems go through a tremendous reorganization during the activation process. Surprisingly, none of the components of intermediate filaments has so far been identified in these cells, perhaps because platelets were considered too motile to have intermediate filaments, the most static structures among the three major cytoskeletal systems. By using two different monoclonal antibodies (II C4 and II D8) here we attempt

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Schissel, SL, RW Shine, RD Brown, MA Perrella, and MD Layne. "Aortic Carboxypeptidase-Like Protein, a Discoidin Domain Protein, Regulates Lung Fibroblast Lamellipodia Formation and Collagen Contraction." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3486.

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Li, Qiong, Yongbin Wang, Wujun Xiong та Jun Mi. "Abstract 1635: MiR-21/Smad 7 signaling determines TGF-β1-induced cancer associated fibroblast (CAF) formation." У Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-1635.

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Christensen, M. A., P. Juhl, D. J. Leeming, and J. M. B. Sand. "Extracellular matrix formation reduction by nintedanib varies in the Scar-in-a-Jar fibroblast model depending on pathway induction." In ERS International Congress 2022 abstracts. European Respiratory Society, 2022. http://dx.doi.org/10.1183/13993003.congress-2022.1715.

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