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Journal articles on the topic 'Flavonoids, chronic respiratory diseases'

Author: Grafiati

Published: 11 March 2023

Last updated: 31 July 2025

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1

Oršolić, Nada. "Allergic Inflammation: Effect of Propolis and Its Flavonoids." Molecules 27, no. 19 (2022): 6694. http://dx.doi.org/10.3390/molecules27196694.

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The incidence of allergic diseases and their complications are increasing worldwide. Today, people increasingly use natural products, which has been termed a “return to nature”. Natural products with healing properties, especially those obtained from plants and bees, have been used in the prevention and treatment of numerous chronic diseases, including allergy and/or inflammation. Propolis is a multi-component resin rich in flavonoids, collected and transformed by honeybees from buds and plant wounds for the construction and adaptation of their nests. This article describes the current views r

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Bora, Alina, Liliana Pacureanu, and Luminita Crisan. "In Silico Study of Some Natural Flavonoids as Potential Agents against COVID-19: Preliminary Results." Chemistry Proceedings 3, no. 1 (2020): 25. http://dx.doi.org/10.3390/ecsoc-24-08343.

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Flavonoids, widely distributed in fruits, vegetables, and medicinal herbs, are compounds with multiple biological benefits to human health from anti-inflammatory, antioxidant, anticancer, antibacterial to antiviral activity. Coronavirus disease 2019 (COVID-19), a serious concern in the world today, is a respiratory tract disease involving moderate to severe symptoms of pneumonia, with a major incidence in older people and patients having chronic diseases. This emergency health situation led us to evaluate the possible use of natural products to prevent respiratory diseases. The present study a

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Mattioli, Veronica, Maria Elisabetta Zanolin, Lucia Cazzoletti, et al. "Dietary flavonoids and respiratory diseases: a population-based multi-case–control study in Italian adults." Public Health Nutrition 23, no. 14 (2020): 2548–56. http://dx.doi.org/10.1017/s1368980019003562.

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AbstractObjective:To analyse the associations between chronic respiratory diseases and intakes of total flavonoids and their major subclasses (flavanones, anthocyanins, flavan-3-ols, flavonols, flavones, polymers and proanthocyanidins).Design:Multi-case–control study.Setting:The analysis was conducted in the frame of the Genes Environment Interaction in Respiratory Diseases (GEIRD) study. The European Prospective Investigation into Cancer and Nutrition FFQ was used to ascertain dietary intake. Multinomial regression models adjusting for age, sex, centre, BMI, smoking habit, alcohol intake, edu

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Hosawi, Salman. "Current Update on Role of Hesperidin in Inflammatory Lung Diseases: Chemistry, Pharmacology, and Drug Delivery Approaches." Life 13, no. 4 (2023): 937. http://dx.doi.org/10.3390/life13040937.

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Inflammation is a common feature of many respiratory diseases, such as pneumonia, asthma, pulmonary fibrosis, chronic obstructive pulmonary disease (COPD), lung cancer, acute lung injury, and COVID-19. Flavonoids have demonstrated their anti-inflammatory and antioxidant effects by influencing inflammation at different stages and majorly impacting several respiratory diseases’ onset and development. According to current studies, hesperidin, one of the most abundant polyphenols, can inhibit transcription factors or regulatory enzymes essential for controlling inflammation-linked mediators, inclu

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Liga, Sergio, and Cristina Paul. "Puerarin—A Promising Flavonoid: Biosynthesis, Extraction Methods, Analytical Techniques, and Biological Effects." International Journal of Molecular Sciences 25, no. 10 (2024): 5222. http://dx.doi.org/10.3390/ijms25105222.

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Flavonoids, a variety of plant secondary metabolites, are known for their diverse biological activities. Isoflavones are a subgroup of flavonoids that have gained attention for their potential health benefits. Puerarin is one of the bioactive isoflavones found in the Kudzu root and Pueraria genus, which is widely used in alternative Chinese medicine, and has been found to be effective in treating chronic conditions like cardiovascular diseases, liver diseases, gastric diseases, respiratory diseases, diabetes, Alzheimer’s disease, and cancer. Puerarin has been extensively researched and used in

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SHAH, ZAHIDA, Sabeeha Shafi, and Tabasum Ali. "Phytomedicines as potent alternative Anti-microbial naturopathic treatment in Chronic Communicable diseases: A Review." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 952–53. http://dx.doi.org/10.22270/jddt.v9i3-s.3071.

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Communicable Diseases are caused by various opportunistic pathogenic micro-organisms that pose a serious health threat to the health of human beings. The contagious diseases are spread by various pathogenic micro-organisms like bacteria, viruses, fungi, bacteria or Protozoa through various mediums like air, blood, feces or through other blood fluids etc. Malaria, Respiratory disorders, fever, Measles, athletes foot, rabies are some common examples of these diseases. Allopathic management of these diseases by synthetic drugs pose serious health threats like multi-drug resistance. Phytomedicines

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Hidanah, Sri, Emy Koestanti Sabdoningrum, Retno Sri Wahjuni, and Arimbi Arimbi. "Implementation of Meniran Extract (Phyllanthus Niruri Linn) on the Performance of Broiler Chickens Infected by Mycoplasma gallisepticum Caused Chronic Respiratory Disease." KnE Life Sciences 3, no. 6 (2017): 296. http://dx.doi.org/10.18502/kls.v3i6.1138.

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Chronic respiratory disease (CRD) of chicken is a disease that has great economic losses in poultry industry in the world. The losses are mainly due to the decrease of body weight gain, feed efficiencies, hatchabilities and increase conversion of the feed, of embryo mortality. The main causative agent of Chronic Respiratory Disease (CRD) is Mycoplasma gallisepticum. Mycoplasma gallisepticum attacks the respiratory tract, especially in young broiler chickens with age ranged 3-5 weeks. CRD treatment usually uses macrolide antibiotics, because it has proven effective to inhibit protein synthesis.

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Santana, Fernanda Paula R., Nathalia M. Pinheiro, Márcia Isabel B. Mernak, et al. "Evidences of Herbal Medicine-Derived Natural Products Effects in Inflammatory Lung Diseases." Mediators of Inflammation 2016 (2016): 1–14. http://dx.doi.org/10.1155/2016/2348968.

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Pulmonary inflammation is a hallmark of many respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), and acute respiratory syndrome distress (ARDS). Most of these diseases are treated with anti-inflammatory therapy in order to prevent or to reduce the pulmonary inflammation. Herbal medicine-derived natural products have been used in folk medicine and scientific studies to evaluate the value of these compounds have grown in recent years. Many substances derived from plants have the biological effectsin vitroandin vivo, such as flavonoids, alkaloids, and terpenoids. Am

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Ziółkowska, Paulina, Michalina Strzedulla, Mirosław Śnit, Dariusz Szczyra, and Roman Kuźniewicz. "The (un)known herb – fennel." Herba Polonica 70, no. 1 (2024): 57–65. http://dx.doi.org/10.5604/01.3001.0054.4607.

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Fennel (Foeniculum vulgare) was one of the basic herbs used in traditional medicine. Nowadays, it is also a promising therapeutic factor in the treatment of many diseases. The plant is ascribed to have antioxidant, hypoglycemic, hypotensive, diuretic, expectorant, antidepressant, antianxiety, anticancer, anti-inflammatory as well as antispasmodic effects. Due to the following properties, fennel potentially is able to play an important role in the treatment of diabetes mellitus, hypertension, respiratory diseases (acute lung injury, chronic obstructive pulmonary disease [COPD], adult respirator

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Fu, Yaw-Syan, Ning Kang, Yanping Yu, et al. "Polyphenols, flavonoids and inflammasomes: the role of cigarette smoke in COPD." European Respiratory Review 31, no. 164 (2022): 220028. http://dx.doi.org/10.1183/16000617.0028-2022.

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COPD is predicted to become the third leading cause of morbidity and mortality worldwide by 2030. Cigarette smoking (active or passive) is one of its chief causes, with about 20% of cigarette smokers developing COPD from cigarette smoke (CS)-induced irreversible damage and sustained inflammation of the airway epithelium. Inflammasome activation leads to the cleavage of pro-interleukin (IL)-1β and pro-IL-18, along with the release of pro-inflammatory cytokines via gasdermin D N-terminal fragment membrane pores, which further triggers acute phase pro-inflammatory responses and concurrent pyropto

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Koss-Mikołajczyk, Izabela, Monika Baranowska, Vanja Todorovic, et al. "Prophylaxis of Non-communicable Diseases: Why Fruits and Vegetables may be Better Chemopreventive Agents than Dietary Supplements Based on Isolated Phytochemicals?" Current Pharmaceutical Design 25, no. 16 (2019): 1847–60. http://dx.doi.org/10.2174/1381612825666190702093301.

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The World Health Organization (WHO) report from 2014 documented that non-communicable socalled civilization diseases such as cardiovascular disease, chronic respiratory diseases, cancer or type 2 diabetes are responsible for over 50% of all premature deaths in the world. Research carried out over the past 20 years has provided data suggesting that diet is an essential factor influencing the risk of development of these diseases. The increasing knowledge on chemopreventive properties of certain food ingredients, in particular, those of plant origin, opened the discussion on the possibility to u

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Zullkiflee, Nadzirah, Hussein Taha, and Anwar Usman. "Propolis: Its Role and Efficacy in Human Health and Diseases." Molecules 27, no. 18 (2022): 6120. http://dx.doi.org/10.3390/molecules27186120.

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With technological advancements in the medicinal and pharmaceutical industries, numerous research studies have focused on the propolis produced by stingless bees (Meliponini tribe) and Apis mellifera honeybees as alternative complementary medicines for the potential treatment of various acute and chronic diseases. Propolis can be found in tropical and subtropical forests throughout the world. The composition of phytochemical constituents in propolis varies depending on the bee species, geographical location, botanical source, and environmental conditions. Typically, propolis contains lipid, be

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Reddy, Amala, and Sujatha Sundaresan. "PHYTOCHEMICAL ANALYSIS AND SUPPRESSION OF INFLAMMATORY TARGETS BY ADATHODA VASICA." Asian Journal of Pharmaceutical and Clinical Research 11, no. 5 (2018): 162. http://dx.doi.org/10.22159/ajpcr.2018.v11i5.24243.

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Objectives: A persistent and chronic inflammation may act as an underlying definition for many of the long-term illness such as diabetic foot ulcer, Alzheimer’s disease and rheumatoid arthritis. Folklore medicinal plants provide immense health benefits with new remedies. Active compounds from plants containing alkaloids and phenolic compounds (flavonoids and tannins) possess antioxidant and anti-inflammatory activity. The leaves of Adhatoda vasica are most known for its effectiveness in treating respiratory diseases such as asthma, chronic bronchitis, and other respiratory conditions. In this

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Wahab, Shadma, Sivakumar Annadurai, Shahabe Saquib Abullais, et al. "Glycyrrhiza glabra (Licorice): A Comprehensive Review on Its Phytochemistry, Biological Activities, Clinical Evidence and Toxicology." Plants 10, no. 12 (2021): 2751. http://dx.doi.org/10.3390/plants10122751.

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There are more than 30 species of Glycyrrhiza genus extensively spread worldwide. It was the most prescribed herb in Ancient Egyptian, Roman, Greek, East China, and the West from the Former Han era. There are various beneficial effects of licorice root extracts, such as treating throat infections, tuberculosis, respiratory, liver diseases, antibacterial, anti-inflammatory, and immunodeficiency. On the other hand, traditional medicines are getting the attraction to treat many diseases. Therefore, it is vital to screen the medicinal plants to find the potential of new compounds to treat chronic

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Maluwa, Chikondi, Blecious Zinan’dala, Hataichanok Chuljerm, Wason Parklak, and Kanokwan Kulprachakarn. "Watercress (Nasturtium officinale) as a Functional Food for Non-Communicable Diseases Prevention and Management: A Narrative Review." Life 15, no. 7 (2025): 1104. https://doi.org/10.3390/life15071104.

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Non-communicable diseases (NCDs) such as cardiovascular disease, diabetes, cancer, and chronic respiratory conditions are the leading causes of death globally, largely driven by modifiable lifestyle factors. With growing interest in dietary strategies for NCDs prevention and management, functional foods like watercress (Nasturtium officinale) have attracted attention for their rich phytochemical content and potential health benefits. This narrative review synthesizes 88 sources published between 2019 and March 2025, exploring the effects of watercress bioactive compounds on major NCDs. Watercr

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Febin, K. P.* Syamjith P. Dr. E. Tamil Jothi. "Review On Anti-Oxidant Potential of Gymnema sylvestre." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 1682–92. https://doi.org/10.5281/zenodo.15046734.

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Oxidative stress plays a significant role in the development of chronic inflammatory diseases, such as cancer, diabetes, neurological disorders, and cardiovascular diseases, resulting from an imbalance between pro-oxidants and antioxidants. Gymnema sylvestre, a medicinal plant used in Ayurvedic medicine, offers a natural alternative to synthetic drugs for managing these conditions. Known for its antioxidant, anti-inflammatory, anti-diabetic, and hepatoprotective properties, Gymnema sylvestre contains bioactive compounds like gymnemic acids, flavonoids, and saponins that contribute to its thera

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Gurov, A. V., and A. V. Muzhichkova. "Modern possibilities of herbal medicine in the treatment of acute inflammatory diseases of the upper respiratory tract." Meditsinskiy sovet = Medical Council, no. 18 (December 1, 2021): 127–33. http://dx.doi.org/10.21518/2079-701x-2021-18-127-133.

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The article provides data on the effectiveness of the use of the drug in the treatment of acute, chronic and recurrent diseases of the respiratory tract and ENT organs. The drug is an extract of Pelargonium sidoides. From the standpoint of modern pharmacology, it is known that the use of natural products based on plant materials ensures safety and the absence of pronounced side effects. The main active ingredients of pelargonium are phenolic compounds: coumarins, flavonoids and phenolic acids. The article details the biochemical and pharmacological properties of each of the above groups of com

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Kim, Min-Young, Jung-In Kim, Sang-Woo Kim, et al. "Influence of Secondary Metabolites According to Maturation of Perilla (Perilla frutescens) on Respiratory Protective Effect in Fine Particulate Matter (PM2.5)-Induced Human Nasal Cell." International Journal of Molecular Sciences 25, no. 22 (2024): 12119. http://dx.doi.org/10.3390/ijms252212119.

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Fine particulate matter (PM2.5) exposure worsens chronic respiratory diseases through oxidative stress and inflammation. Perilla frutescens (L.) has potential respiratory protective properties, but the impact of growth stages on its beneficial metabolites is unclear. We aimed to evaluate how different growth stages affect phenolic acids, flavonoids, and polycosanols in perilla seeds and flowers and their efficacy in countering PM2.5-induced damage. Perilla seeds and flowers from five varieties at 10, 20, 30, and 40 days post-flowering were analyzed for metabolite content. Their antioxidant, an

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Jiang, T. Alan. "Health Benefits of Culinary Herbs and Spices." Journal of AOAC INTERNATIONAL 102, no. 2 (2019): 395–411. http://dx.doi.org/10.5740/jaoacint.18-0418.

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Abstract Spices and herbs have been in use for centuries both for culinary and medicinal purposes. Spices not only enhance the flavor, aroma, and color of foodand beverages, but they can also protect from acuteand chronic diseases. More Americans are considering the use of spices and herbs for medicinal and therapeutic/remedy use, especially for various chronicconditions. There is now ample evidence that spicesand herbs possess antioxidant, anti-inflammatory, antitumorigenic, anticarcinogenic, and glucose- and cholesterol-lowering activities as well as properties that affect cognition and mood

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Wunpathe, Chutamas, and Anongnard Kasorn. "A Review of the Beneficial Effects of Hesperidin on Urban Diseases." Vajira Medical Journal : Journal of Urban Medicine 69, no. 2 (2025): e272526. https://doi.org/10.62691/vmj.2025.272526.

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The urban environment is increasingly recognized as a key determinant of health, influencing lifestyles that can either promote or hinder well-being. This review aims to summarize recent studies (2020-2024) on the potential therapeutic effects of hesperidin, a flavonoid derived from citrus fruits, in addressing urban-related diseases worsened by pollution, sedentary habits, poor nutrition, and chronic stress. These health conditions include cardiovascular diseases respiratory issues, metabolic disorders, neurodegenerative diseases, mental health challenges, infectious diseases, and cancer. Hes

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Ptak, Jakub, Marek Miśkiewicz, Rafał Noga, et al. "Propolis in Human Health: Unraveling Chemistry, Applications, and Efficacy." Quality in Sport 21 (September 9, 2024): 54248. http://dx.doi.org/10.12775/qs.2024.21.54248.

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The paper explores the diverse aspects of propolis, a resinous substance created by bees from botanical sources, presenting a comprehensive overview of its chemistry, applications, and efficacy in human health. Propolis, colloquially known as "bee glue," serves as a versatile material in hive construction and defense against diseases and predators. Its chemical composition, influenced by geographic origins, comprises a myriad of bioactive compounds, including flavonoids, phenolic acids, terpenoids, and more. The study delves into the pharmacological activities of propolis, emphasizing its anti

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Tanno, Yasuo, Yasunori Kakuta, Takashi Aikawa, Yuriko Shindoh, Isao Ohno, and Tamotsu Takishima. "Effects of Qing-Fei-Tang (Seihai-to) and Baicalein, Its Main Component Flavonoid, on Lucigenin-Dependent Chemiluminescence and Leukotriene-Dependence Chemiluminescence and Leukotriene B4 Synthesis of Human Alveolar Macrophages." American Journal of Chinese Medicine 16, no. 03n04 (1988): 145–54. http://dx.doi.org/10.1142/s0192415x88000212.

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A traditional Chinese remedy, Qing-Fei-Tang (Seihai-to, T90), has been used for treatment of chronic respiratory diseases with long-lasting cough and sputum, e.g. chronic bronchitis. We examined the effect of T90 and its main component flavonoid, baicalein, on the lucigenin-dependent chemiluminescence (CL) and leukotrine B4 (LTB4) synthesis of human alveolar macrophages (AM). AM were obtained by bronchoalveolar lavage from patients with various respiratory diseases, including sacroidosis, idiopathic pulmonary fibrosis, bronchial asthma, chronic bronchitis and lung cancer. CL were observed by s

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Thomas, Robert, Madeleine Williams, Jeffrey Aldous, and Kevin Wyld. "Multiple Biological Mechanisms for the Potential Influence of Phytochemicals on Physical Activity Performance: A Narrative Review." Nutraceuticals 3, no. 3 (2023): 353–65. http://dx.doi.org/10.3390/nutraceuticals3030027.

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Natural phytochemicals (PCs) are responsible for the taste, colour, and aroma of many edible plants. Cohort studies have linked higher intake to a reduced risk of chronic degenerative diseases and premature ageing. The ability of foods rich in PCs, such as phytanthocyanins, apigenin, flavonols, flavonoids, bioflavonoids, gallic acid, ellagic acid, quercetin, and ellagitannins, to support physical activity has also been highlighted in a number of published pre-clinical and prospective clinical studies. This literature mostly emphasises the ability of PCs to enhance the adaptive upregulation of

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Thakur, Anjali, Ankush Dhiman, Anjali Sharma, and Nutan Sharma. "Antiasthmatic Potential of Methanolic Extracts of Pistacia integerrima." Research & Review: Drugs and Drugs Development 7, no. 2 (2025): 1–15. https://doi.org/10.46610/rrddd.2025.v07i02.001.

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An infection happens when a germ affects the body and causes problems by reacting with the immune system. Diseases caused by infections can spread from person to person. These infections can last a short time (acute) or a long time (chronic). Asthma, a multifactorial respiratory condition, particularly prevalent among pediatric populations, has prompted interest in alternative treatments with fewer side effects. Numerous medicinal plants have been traditionally employed for asthma management, including Glycyrrhiza glabra, Adhatoda vasica, Albizzia lebbeck, Ephedra sinica, and others, each cont

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Demir, Elif. "Pharmacological studies of sumac plant on COVID-19." Atlantic Journal of Medical Science and Research 2, no. 3 (2022): 69–71. http://dx.doi.org/10.55358/atjmed.2022.08.015.

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Since 2019, the COVID-19 virus has caused severe lung damage and acute respiratory syndrome, leading to global epidemics with high morbidity and mortality. The world health organization has declared it a cause of the pandemic. At the beginning of 2020, many national and international organizations urgently took action to develop vaccines, and dozens of approved vaccines have been developed so far. Despite the significant effectiveness of vaccines, the continuation of deaths because of COVID-19 has increased people’s interest in traditional medicine. The uncertainty in the diagnosis, prevention

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Koch, Christiane E., Goutham K. Ganjam, Juliane Steger, et al. "The dietary flavonoids naringenin and quercetin acutely impair glucose metabolism in rodents possibly via inhibition of hypothalamic insulin signalling." British Journal of Nutrition 109, no. 6 (2012): 1040–51. http://dx.doi.org/10.1017/s0007114512003005.

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Secondary metabolites of herbs and spices are widely used as an alternative strategy in the therapy of various diseases. The polyphenols naringenin, quercetin and curcumin have been characterised as anti-diabetic agents. Conversely, in vitro, naringenin and quercetin are described to inhibit phosphoinositide-3-kinase (PI3K), an enzyme that is essential for the neuronal control of whole body glucose homoeostasis. Using both in vitro and in vivo experiments, we tested whether the inhibitory effect on PI3K occurs in neurons and if it might affect whole body glucose homoeostasis. Quercetin was fou

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Mr. Nilesh N Shinde, Mr Nilesh N. Shinde, Ms Annapurna G. Dawale Ms. Annapurna G. Dawale, Mr Rohan R. Dhanke Mr. Rohan R Dhanke, et al. "Unveiling the Phytopharmacology of Tinospora cordifolia: A Multifunctional Medicinal Marve." International Journal of Pharmaceutical Research and Applications 10, no. 2 (2025): 2224–29. https://doi.org/10.35629/4494-100222242229.

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known as Giloy or Guduchi, is a renowned medicinal plant in traditional Indian systems of medicine such as Ayurveda and Siddha. A member of the Menispermaceae family, this deciduous climbing shrub is native to tropical regions across Asia, Africa, and Australia. Revered for its adaptogenic and immunomodulatory capabilities, T. cordifolia has been traditionally employed to promote overall wellness and manage a wide range of ailments. Its broad pharmacological spectrum is attributed to a rich phytochemical profile, including alkaloids (e.g., berberine, palmatine), diterpenoid lactones (e.g., tin

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Liu, Siqi, Mengli Zhong, Hao Wu, Weiwei Su, Yonggang Wang, and Peibo Li. "Potential Beneficial Effects of Naringin and Naringenin on Long COVID—A Review of the Literature." Microorganisms 12, no. 2 (2024): 332. http://dx.doi.org/10.3390/microorganisms12020332.

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Coronavirus disease 2019 (COVID-19) caused a severe epidemic due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Recent studies have found that patients do not completely recover from acute infections, but instead, suffer from a variety of post-acute sequelae of SARS-CoV-2 infection, known as long COVID. The effects of long COVID can be far-reaching, with a duration of up to six months and a range of symptoms such as cognitive dysfunction, immune dysregulation, microbiota dysbiosis, myalgic encephalomyelitis/chronic fatigue syndrome, myocarditis, pulmonary fibrosis, cough, dia

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Russo, Caterina, Giovanni Enrico Lombardo, Giuseppe Bruschetta, Antonio Rapisarda, Alessandro Maugeri, and Michele Navarra. "Bergamot Byproducts: A Sustainable Source to Counteract Inflammation." Nutrients 16, no. 2 (2024): 259. http://dx.doi.org/10.3390/nu16020259.

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Chronic inflammation is the result of an acute inflammatory response that fails to eliminate the pathogenic agent or heal the tissue injury. The consequence of this failure lays the foundations to the onset of several chronic ailments, including skin disorders, respiratory and neurodegenerative diseases, metabolic syndrome, and, eventually, cancer. In this context, the long-term use of synthetic anti-inflammatory drugs to treat chronic illnesses cannot be tolerated by patients owing to the severe side effects. Based on this, the need for novel agents endowed with anti-inflammatory effects prom

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Eunice, Wothaya Muthee*1 Mathew Ngugi1 Stephen Gitahi2 Alex Machocho1. "Ficus Sycomorus: Ecological, Cultural, And Medicinal Insights into A Timeless Tree." International Journal of Scientific Research and Technology 2, no. 4 (2025): 342–47. https://doi.org/10.5281/zenodo.15236250.

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<em>Ficus sycomorus</em>, commonly known as the sycamore fig, is a large deciduous tree native to tropical and subtropical regions of Africa, the Mediterranean, and the Middle East. It plays a crucial ecological role in riparian zones, supporting biodiversity and preventing soil erosion. Historically, the tree has held significant cultural and spiritual importance, particularly in ancient Egypt and various African cultures, where it symbolizes fertility, protection, and nourishment. Medicinally, <em>Ficus sycomorus</em> has been utilized for centuries, with various parts of the tree—such

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Ding, Kaixi, Wei Jiang, Wenling Zhan, et al. "The therapeutic potential of quercetin for cigarette smoking–induced chronic obstructive pulmonary disease: a narrative review." Therapeutic Advances in Respiratory Disease 17 (January 2023): 175346662311708. http://dx.doi.org/10.1177/17534666231170800.

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Quercetin is a flavonoid with antioxidant and anti-inflammatory properties. Quercetin has potentially beneficial therapeutic effects for several diseases, including cigarette smoking–induced chronic obstructive pulmonary disease (CS-COPD). Many studies have shown that quercetin’s antioxidant and anti-inflammatory properties have positive therapeutic potential for CS-COPD. In addition, quercetin’s immunomodulatory, anti-cellular senescence, mitochondrial autophagy–modulating, and gut microbiota–modulating effects may also have therapeutic value for CS-COPD. However, there appears to be no revie

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Cavallero, Andrea, Francesca Vidotto, Cristiana Sbrana, Laryssa Peres Fabbri, Giulio Petroni та Morena Gabriele. "Antioxidant-Rich Polyfloral Bee Pollen Exerts Antimicrobial Activity and Anti-Inflammatory Effect in A549 Lung Epithelial Cells by Modulating the NF-κB Pathway". Foods 14, № 5 (2025): 802. https://doi.org/10.3390/foods14050802.

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Bee pollen is produced by honeybees from the agglutination of pollen grains belonging to one or more plant species. Although it is intended to be a nutritional source for the hive, its remarkable concentration of nutrients and phytochemicals, combined with its pleasant organoleptic qualities, makes it appealing for human consumption. This study examined the phytochemical content and the antioxidant and antimicrobial activities of a polyfloral bee pollen collected in Tuscany (Italy). Additionally, its less studied anti-inflammatory potential towards tumor necrosis factor-alpha (TNF-α)-inflamed

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Holland, W. W. "Chronic respiratory diseases." Journal of Epidemiology & Community Health 47, no. 1 (1993): 4–5. http://dx.doi.org/10.1136/jech.47.1.4.

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Rabe, Klaus F. "Understanding chronic respiratory diseases." Lancet 372, no. 9643 (2008): 1027–28. http://dx.doi.org/10.1016/s0140-6736(08)61426-9.

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Sun, Mengshi, and Qin Ding. "Correlation of dietary flavonoid intake with chronic bronchitis, emphysema, and asthma in U.S. adults: A large, national, cross-sectional study." PLOS ONE 19, no. 10 (2024): e0309310. http://dx.doi.org/10.1371/journal.pone.0309310.

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Objective To explore the relationship between dietary flavonoids and bronchitis, emphysema and asthma. Method A total of 11743 United States adults were extracted from the National Health and Nutrition Examination Survey (NHANES) in 2007–2008, 2009–2010 and 2017–2018. Of these, 47.7% were male and 52.3% female. Dietary flavonoid intake assessed using FDNNS and 24-hour dietary recall data. Inclusion of demographics (gender, age, education, family income), behavioral factors (BMI, smoking, drinking status, diet), chronic disease information (diabetes, hypertension) as covariates to eliminate con

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Atrahimovich, Dana, Dorit Avni, and Soliman Khatib. "Flavonoids-Macromolecules Interactions in Human Diseases with Focus on Alzheimer, Atherosclerosis and Cancer." Antioxidants 10, no. 3 (2021): 423. http://dx.doi.org/10.3390/antiox10030423.

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Flavonoids, a class of polyphenols, consumed daily in our diet, are associated with a reduced risk for oxidative stress (OS)-related chronic diseases, such as cardiovascular disease, neurodegenerative diseases, cancer, and inflammation. The involvement of flavonoids with OS-related chronic diseases have been traditionally attributed to their antioxidant activity. However, evidence from recent studies indicate that flavonoids’ beneficial impact may be assigned to their interaction with cellular macromolecules, rather than exerting a direct antioxidant effect. This review provides an overview of

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Jannat, Khoshnur, Alok K. Paul, Tohmina A. Bondhon, et al. "Nanotechnology Applications of Flavonoids for Viral Diseases." Pharmaceutics 13, no. 11 (2021): 1895. http://dx.doi.org/10.3390/pharmaceutics13111895.

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Recent years have witnessed the emergence of several viral diseases, including various zoonotic diseases such as the current pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Other viruses, which possess pandemic-causing potential include avian flu, Ebola, dengue, Zika, and Nipah virus, as well as the re-emergence of SARS (Severe Acute Respiratory Syndrome) and MERS (Middle East Respiratory Syndrome) coronaviruses. Notably, effective drugs or vaccines against these viruses are still to be discovered. All the newly approved vaccines against the SARS-CoV-2-indu

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Hussain, Tarique, Ghulam Murtaza, Huansheng Yang, Muhammad S. Kalhoro, and Dildar H. Kalhoro. "Exploiting Anti-Inflammation Effects of Flavonoids in Chronic Inflammatory Diseases." Current Pharmaceutical Design 26, no. 22 (2020): 2610–19. http://dx.doi.org/10.2174/1381612826666200408101550.

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Background: Inflammation is a complex response of the host defense system to different internal and external stimuli. It is believed that persistent inflammation may lead to chronic inflammatory diseases such as, inflammatory bowel disease, neurological and cardiovascular diseases. Oxidative stress is the main factor responsible for the augmentation of inflammation via various molecular pathways. Therefore, alleviating oxidative stress is effective a therapeutic option against chronic inflammatory diseases. Methods: This review article extends the knowledge of the regulatory mechanisms of flav

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Shangyao Mo, Hao Deng, Yong Xie, Lixia Yang та Lili Wen. "Chryseriol attenuates the progression of OVA-induced asthma in mice through NF-κκB/HIF-1αα and MAPK/STAT1 pathways". Allergologia et Immunopathologia 51, № 1 (2023): 146–53. http://dx.doi.org/10.15586/aei.v51i1.776.

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Background: Asthma is a hackneyed chronic inflammatory disease of the airway. Chryseriol (CSR) is a kind of flavonoid, and has the effect of bronchiectasis, indicating its potential application for treating respiratory diseases. However, the functions of CSR in asthma have not been reported till now. Materials and methods: The histopathologic changes of the lung tissues were assessed by hematoxylin and eosin staining. The cell apoptosis was identified through terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling assay. Total numbers of eosinophils, neutrophils, and macrophages

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Purghè, Beatrice, Marcello Manfredi, Beatrice Ragnoli, Gianluca Baldanzi, and Mario Malerba. "Exosomes in chronic respiratory diseases." Biomedicine & Pharmacotherapy 144 (December 2021): 112270. http://dx.doi.org/10.1016/j.biopha.2021.112270.

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Blasi, Francesco. "Lung Diseases: Chronic Respiratory Infections." International Journal of Molecular Sciences 19, no. 10 (2018): 3051. http://dx.doi.org/10.3390/ijms19103051.

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Russo, Patrizia, Giulia Prinzi, Palma Lamonaca, Vittorio Cardaci, and Massimo Fini. "Flavonoids and Reduction of Cardiovascular Disease (CVD) in Chronic Obstructive Pulmonary Disease (COPD)." Current Medicinal Chemistry 26, no. 39 (2019): 7048–58. http://dx.doi.org/10.2174/0929867325666180514100640.

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Background: Chronic Obstructive Pulmonary Disease (COPD) and Cardiovascular Diseases (CV) Often Coexist. COPD and CVD are complex diseases characterized by a strict interaction between environment and genetic. The mechanisms linking these two diseases are complex, multifactorial and not entirely understood, influencing the therapeutic approach. COPD is characterized by several comorbidities, it hypothesized the treatment of cardiovascular co-morbidities that may reduce morbidity and mortality. Flavonoids are an important class of plant low molecular weight Secondary Metabolites (SMs). Convinci

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Yang, Yang, Xin Jin, Xinyi Jiao, et al. "Advances in Pharmacological Actions and Mechanisms of Flavonoids from Traditional Chinese Medicine in Treating Chronic Obstructive Pulmonary Disease." Evidence-Based Complementary and Alternative Medicine 2020 (December 31, 2020): 1–10. http://dx.doi.org/10.1155/2020/8871105.

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Chronic obstructive pulmonary disease (COPD) is a common respiratory disease with high morbidity and mortality. The conventional therapies remain palliative and have various undesired effects. Flavonoids from traditional Chinese medicine (TCM) have been proved to exert protective effects on COPD. This review aims to illuminate the poly-pharmacological properties of flavonoids in treating COPD based on laboratory evidences and clinical data and points out possible molecular mechanisms. Animal/laboratory studies and randomised clinical trials about administration of flavonoids from TCM for treat

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Rodriguez-Roisin, Roberto, Sonja D. Bartolome, Gérard Huchon, and Michael J. Krowka. "Inflammatory bowel diseases, chronic liver diseases and the lung." European Respiratory Journal 47, no. 2 (2016): 638–50. http://dx.doi.org/10.1183/13993003.00647-2015.

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This review is devoted to the distinct associations of inflammatory bowel diseases (IBD) and chronic liver disorders with chronic airway diseases, namely chronic obstructive pulmonary disease and bronchial asthma, and other chronic respiratory disorders in the adult population. While there is strong evidence for the association of chronic airway diseases with IBD, the data are much weaker for the interplay between lung and liver multimorbidities. The association of IBD, encompassing Crohn's disease and ulcerative colitis, with pulmonary disorders is underlined by their heterogeneous respirator

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Nazarova, Karina. "Chronic Respiratory Diseases: Treatment and Prevention." Journal of Complementary Medicine Research 13, no. 3 (2022): 76. http://dx.doi.org/10.5455/jcmr.2022.13.03.16.

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The article investigates the therapeutic and preventive aspects of chronic respiratory diseases. The authors note that chronic respiratory diseases are among the most common non-communicable diseases worldwide, mainly due to the widespread distribution of harmful environmental, occupational and behavioral inhalation effects. In addition to chronic obstructive pulmonary disease (COPD) and asthma, chronic respiratory diseases include interstitial lung disease, pulmonary sarcoidosis, and pneumoconioses such as silicosis and asbestos. Unfortunately, chronic respiratory diseases have received propo

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Bansal, Vishal, and Rajendra Prasad. "Pulmonary Rehabilitation in Chronic Respiratory Diseases." Indian Journal of Chest Diseases and Allied Sciences 56, no. 3 (2022): 147–48. http://dx.doi.org/10.5005/ijcdas-56-3-147.

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Chetambath, Ravindran. "Pulmonary rehabilitation in chronic respiratory diseases." Journal of Advanced Lung Health 2, no. 1 (2022): 5. http://dx.doi.org/10.4103/jalh.jalh_9_21.

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Froes, Filipe, Nicolas Roche, and Francesco Blasi. "Pneumococcal vaccination and chronic respiratory diseases." International Journal of Chronic Obstructive Pulmonary Disease Volume 12 (December 2017): 3457–68. http://dx.doi.org/10.2147/copd.s140378.

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Viegi, Giovanni, Sara Maio, Salvatore Fasola, and Sandra Baldacci. "Global Burden of Chronic Respiratory Diseases." Journal of Aerosol Medicine and Pulmonary Drug Delivery 33, no. 4 (2020): 171–77. http://dx.doi.org/10.1089/jamp.2019.1576.

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Bousquet, J., R. Dahl, and N. Khaltaev. "Global Alliance against Chronic Respiratory Diseases." European Respiratory Journal 29, no. 2 (2006): 233–39. http://dx.doi.org/10.1183/09031936.00138606.

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