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Journal articles on the topic 'Furanones'

Author: Grafiati

Published: 4 June 2021

Last updated: 27 July 2025

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1

Ndagijimana, Maurice, Melania Vallicelli, P. Sandro Cocconcelli, et al. "Two 2[5H]-Furanones as Possible Signaling Molecules in Lactobacillus helveticus." Applied and Environmental Microbiology 72, no. 9 (2006): 6053–61. http://dx.doi.org/10.1128/aem.00363-06.

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ABSTRACT Two 2[5H]-furanones, in association with medium-chain fatty acids, were released in whey by Lactobacillus helveticus exposed to oxidative and heat stresses. This species plays an important role in cheese technology, particularly for Swiss-type cheeses and Grana cheese. Moreover, it significantly contributes to cheese ripening by means of an early autolysis and the release of enzymes during processing. Experimental evidence of the involvement of the two 2[5H]-furanones, detected by a gas chromatography-mass spectrometry/solid-phase microextraction technique, in the autolysis phenomenon

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2

Janssens, Joost C. A., Hans Steenackers, Stijn Robijns, et al. "Brominated Furanones Inhibit Biofilm Formation by Salmonella enterica Serovar Typhimurium." Applied and Environmental Microbiology 74, no. 21 (2008): 6639–48. http://dx.doi.org/10.1128/aem.01262-08.

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ABSTRACT Salmonella enterica serovar Typhimurium is a main cause of bacterial food-borne diseases. As Salmonella can form biofilms in which it is better protected against antimicrobial agents on a wide diversity of surfaces, it is of interest to explore ways to inhibit biofilm formation. Brominated furanones, originally extracted from the marine alga Delisea pulchra, are known to interfere with biofilm formation in several pathogens. In this study, we have synthesized a small focused library of brominated furanones and tested their activity against S. enterica serovar Typhimurium biofilm forma

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3

Rodríguez-López, Pedro, Andrea Emparanza Barrenengoa, Sergio Pascual-Sáez, and Marta López Cabo. "Efficacy of Synthetic Furanones on Listeria monocytogenes Biofilm Formation." Foods 8, no. 12 (2019): 647. http://dx.doi.org/10.3390/foods8120647.

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Furanones are analogues of acylated homoserine lactones with proven antifouling activity in both Gram-positive and Gram-negative bacteria though the interference of various quorum sensing pathways. In an attempt to find new strategies to prevent and control Listeria monocytogenes biofilm formation on stainless steel (SS) surfaces, different concentrations of six synthetic furanones were applied on biofilms formed by strains isolated from food, environmental, and clinical sources grown onto AISI 316 SS coupons. Among the furanones tested, (Z-)-4-Bromo-5-(bromomethylene)-2(5H)-furanone and 3,4-D

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4

Huang, Huicai, Xue Lu, Yukang Mao, and Jinxing Ye. "Asymmetric synthesis of highly functionalized furanones via direct Michael reactions mediated by a bulky primary amine." Organic Chemistry Frontiers 6, no. 8 (2019): 1080–83. http://dx.doi.org/10.1039/c8qo01132j.

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5

Żurawska, Katarzyna, Anna Byczek-Wyrostek, Anna Kasprzycka, and Krzysztof Walczak. "3,4-Dihalo-5-hydroxy-2(5H)-furanones: Highly Reactive Small Molecules." Molecules 29, no. 21 (2024): 5149. http://dx.doi.org/10.3390/molecules29215149.

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3,4-Dichloro-5-hydroxy-2(5H)-furanone and its dibromo analog are highly reactive molecules. Both are members of the 2(5H)-furanone family, which are important as pharmacophores present in drugs and natural products. Compounds possessing the 2(5H)-furanone skeleton isolated from plants and marine organisms exhibit bioactivity against various microorganisms and viruses and can also be used in other medical treatments. The structures of these 3,4-dihalo-2(5H)-furanones cause their high reactivity due to the presence of a carbonyl group on the C2 carbon conjugated with a double bond and a hydroxyl

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6

Liao, Liang, and Didier Villemin. "A Rapid and Efficient One-Pot Synthesis of Substituted 2-(5H)-furanones under focused microwave irradiations." Journal of Chemical Research 2000, no. 4 (2000): 179–81. http://dx.doi.org/10.3184/030823400103166869.

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3-Hydroxy-3-methyl-2-butanone 1 reacted with ethyl cyanocetate in 2 in the presence of sodium ethoxide under focused microwave irradiations to afford 3-cyano-4,5,5-trimethyl-2-( 5H)-furanone 3. Furanone 3 then condensed with aromatic or heteroaromatic aldehydes 4a–h to produce 3-cyano-4-( trans-aryl-vinyl)-5,5-dimethyl-2-( 5H)-furanones 5a–h in high overall yields (71–88%).

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7

Viturro, Carmen I., Juana R. de la Fuente, and Marta S. Maier. "One New Prenylated Furanone and Other non Polar Constituents from Mutisia friesiana." Zeitschrift für Naturforschung B 60, no. 5 (2005): 585–89. http://dx.doi.org/10.1515/znb-2005-0519.

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In addition to the known furanones 1 and 2, the aerial parts of the shrub Mutisia friesiana afforded a new prenylated furanone, Mutisifuranone A (3), together with the known triterpenoids oleanic (4) and ursolic (5) acids and some sesquiterpenoids and n-alkanes. Their structures were elucidated by spectroscopic methods.

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8

Muñoz-Cázares, Naybi, Israel Castillo-Juárez, Rodolfo García-Contreras, et al. "A Brominated Furanone Inhibits Pseudomonas aeruginosa Quorum Sensing and Type III Secretion, Attenuating Its Virulence in a Murine Cutaneous Abscess Model." Biomedicines 10, no. 8 (2022): 1847. http://dx.doi.org/10.3390/biomedicines10081847.

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Quorum sensing (QS) and type III secretion systems (T3SSs) are among the most attractive anti-virulence targets for combating multidrug-resistant pathogenic bacteria. Some halogenated furanones reduce QS-associated virulence, but their role in T3SS inhibition remains unclear. This study aimed to assess the inhibition of these two systems on Pseudomonas aeruginosa virulence. The halogenated furanones (Z)-4-bromo-5-(bromomethylene)-2(5H) (C-30) and 5-(dibromomethylene)-2(5H) (named hereafter GBr) were synthesized, and their ability to inhibit the secretion of type III exoenzymes and QS-controlle

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9

Markus, Victor, Karina Golberg, Kerem Teralı, et al. "Assessing the Molecular Targets and Mode of Action of Furanone C-30 on Pseudomonas aeruginosa Quorum Sensing." Molecules 26, no. 6 (2021): 1620. http://dx.doi.org/10.3390/molecules26061620.

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Quorum sensing (QS), a sophisticated system of bacterial communication that depends on population density, is employed by many pathogenic bacteria to regulate virulence. In view of the current reality of antibiotic resistance, it is expected that interfering with QS can address bacterial pathogenicity without stimulating the incidence of resistance. Thus, harnessing QS inhibitors has been considered a promising approach to overriding bacterial infections and combating antibiotic resistance that has become a major threat to public healthcare around the globe. Pseudomonas aeruginosa is one of th

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10

Hosseinzadeh, Zahra, and Ali Ramazani. "An Overview of the Chemistry and Pharmacological Potentials of Furanones Skeletons." Current Organic Chemistry 23, no. 14 (2019): 1581–99. http://dx.doi.org/10.2174/1385272823666190820111928.

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The furanone structure, a significant group of heterocyclic compounds, is frequently found in natural products that are exhibiting striking pharmacological effects and a growing field of research. They have a wide spectrum of pharmaceutical activity: anticataract, anticancer, antibacterial, anti-inflammatory, anticonvulsant. This review article presents a summary of natural furanones, synthetic methods, and the biological effects of these important compounds. Solid-phase method, cross-coupling reactions, Maillard-type reaction, the cycloaddition of alcohol and phenyl nitrile oxide, and side-ch

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11

Cimmino, Alessio, Patrizia Scafato, Veronique Mathieu, et al. "Natural and Synthetic Furanones with Anticancer Activity." Natural Product Communications 11, no. 10 (2016): 1934578X1601101. http://dx.doi.org/10.1177/1934578x1601101013.

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This paper describes the enantioselective synthesis of analogues of sapinofuranones A and B, namely 5-substitutes dihydro- and 5 H-furan-ones, and their in vitro growth inhibitory activity against six cancer cell lines in comparison with fungal furanones such as diplofuranone A, diplobifuranylones A and B, as well as ( S,S)-enantiomer of sapinofuranone B. The compounds under study displayed weak if any in vitro growth inhibitory activity against the analysed cancer cell lines. However, it seems that among dihydro- and 5 H-furan-ones bearing a 1-hydroxypentyl side chain, the stereochemistry of

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12

Villegas Pañeda, Alejandra Guadalupe, and María Teresa Obdulia Ramírez Apan. "Synthesis and cytotoxic evaluation of protoanemonin and three brominated derivatives." Revista Colombiana de Química 49, no. 3 (2020): 13–18. http://dx.doi.org/10.15446/rcq.v49n3.87159.

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The protoanemonin, a natural furanone, was synthesized from (Z)-4-bromo-5-(bromomethylene)-furan-2(5H)-one by a reductive dehalogenation reaction with zinc. The 5-(dibromomethylene)-2(5H)-furanone and (E)-5-(bromomethylene)-2(5H)-furanone were also synthetized from levulinic acid bromination and acid promoted cyclization. The antiproliferative activity of all synthesized compounds against the human cancer cell lines PC-3 (prostate) and U-251 (glioblastoma) was investigated. The results showed that all the obtained furanones are more active than the reference drug cisplatin, with IC50 values in

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13

John, Jubi, Eliza Târcoveanu, Peter G. Jones, and Henning Hopf. "A tandem Mannich addition–palladium catalyzed ring-closing route toward 4-substituted-3(2H)-furanones." Beilstein Journal of Organic Chemistry 10 (June 27, 2014): 1462–70. http://dx.doi.org/10.3762/bjoc.10.150.

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A facile route towards highly functionalized 3(2H)-furanones via a sequential Mannich addition–palladium catalyzed ring closing has been elaborated. The reaction of 4-chloroacetoacetate esters with imines derived from aliphatic and aromatic aldehydes under palladium catalysis afforded 4-substituted furanones in good to excellent yields. 4-Hydrazino-3(2H)-furanones could also be synthesized from diazo esters in excellent yields by utilising the developed strategy. We could also efficiently transform the substituted furanones to aza-prostaglandin analogues.

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14

Fišera, Lubor, and Peter Oravec. "Stereoselectivity of cycloadditions of arylnitrile oxides to 5-alkoxy-2(5H)-furanone." Collection of Czechoslovak Chemical Communications 52, no. 5 (1987): 1315–24. http://dx.doi.org/10.1135/cccc19871315.

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1,3-Dipolar cycloaddition of arylnitrile oxides to 5-alkoxy-2(5H)-furanones (II) and 5-hydroxy-2(5H)-furanone leads regiospecifically to 4-oxo-3a,4,6,6a-tetrahydrofuro[3,4-d]isoxazole derivatives IIIa-IIIj. The alkoxy derivatives give exclusively products of exo-configuration (III), whereas the hydroxy compound affords a 52 : 48 mixture of both diastereoisomers IIIj and IVj. Reaction of III with ammonia furnished diastereoisomeric tetrahydropyrrolo[3,4-d]isoxazoles V and VI, reaction with hydrazines led to hexahydroisoxazolo[4,5-d]pyridazin-7-one derivatives VII.

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15

Newland, Mike J., Yangang Ren, Max R. McGillen, Lisa Michelat, Véronique Daële, and Abdelwahid Mellouki. "NO<sub>3</sub> chemistry of wildfire emissions: a kinetic study of the gas-phase reactions of furans with the NO<sub>3</sub> radical." Atmospheric Chemistry and Physics 22, no. 3 (2022): 1761–72. http://dx.doi.org/10.5194/acp-22-1761-2022.

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Abstract. Furans are emitted to the atmosphere during biomass burning from the pyrolysis of cellulose. They are one of the major contributing volatile organic compound (VOC) classes to OH and NO3 reactivity in biomass burning plumes. The major removal process of furans from the atmosphere at night is reaction with the nitrate radical, NO3. Here, we report a series of relative rate experiments in the 7300 L indoor simulation chamber at Institut de Combustion Aérothermique Réactivité et Environnement, Centre national de la recherche scientifique (ICARE-CNRS), Orléans, using a number of different

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16

Ramadan, Sayed K., Wael S. I. Abou-Elmagd, and Ahmed I. Hashem. "Alkylation of 2(3H)-Furanones: Inter- versus Intra-Molecular." Letters in Organic Chemistry 17, no. 6 (2020): 430–33. http://dx.doi.org/10.2174/1570178617666191203102528.

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In this review, a survey on the behavior of 2(3H)-furanones as alkylating agents is systematized. It is obvious that the direction of the reaction was mainly dependent on the solvent used. Furanones reacted with AlCl3 in excess benzene, toluene, or anisole to give the corresponding butadienecarboxylic acids via an intermolecular alkylation mode. Carrying out the reaction in tetrachloroethane and nitrobenzene as solvents, the reactions may lead to intramolecular alkylation mode or fail to give any product and the unreacted furanones were isolated, depending upon the electron density on C-2 at t

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17

Shemyakina, Olesya, Olga Volostnykh, Anton Stepanov, Igor Ushakov, and Tatyana Borodina. "Synthesis of Functionalized 5-Amino-3(2H)-furanones via Base-Catalyzed Ring-Cleavage/Recyclization of 4-Cyano-3(2H)-furanones in the Presence of Water." Synthesis 50, no. 24 (2018): 4905–14. http://dx.doi.org/10.1055/s-0037-1609916.

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5-Alkyl/aryl/hetaryl-4-cyano-3(2H)-furanones undergo ring-cleavage/recyclization in the presence of water under mild conditions [MOH (M = Na, K), aqueous ethanol, 20–25 °C] to afford 4-acyl/aroyl/hetaroyl-5-amino-3(2Н)-furanones in 75–99% yields.

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18

Kuehl, Richard, Sameer Al-Bataineh, Oliver Gordon, et al. "Furanone at Subinhibitory Concentrations Enhances Staphylococcal Biofilm Formation by luxS Repression." Antimicrobial Agents and Chemotherapy 53, no. 10 (2009): 4159–66. http://dx.doi.org/10.1128/aac.01704-08.

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ABSTRACT Brominated furanones from marine algae inhibit multicellular behaviors of gram-negative bacteria such as biofilm formation and quorum sensing (QS) without affecting their growth. The interaction of furanone with QS in gram-positive bacteria is unknown. Staphylococci have two QS systems, agr and luxS, which lower biofilm formation by two different pathways, RNAIII upregulation and bacterial detachment, and polysaccharide intercellular adhesin (PIA) reduction, respectively. We synthesized natural furanone compound 2 [(5Z)-4-bromo-5-(bromomethylene)-3-butyl-2(5H)-furanone] from Delisea p

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19

Khabibrakhmanova, Alsu M., Roza G. Faizova, Olga A. Lodochnikova, et al. "The Novel Chiral 2(5H)-Furanone Sulfones Possessing Terpene Moiety: Synthesis and Biological Activity." Molecules 28, no. 6 (2023): 2543. http://dx.doi.org/10.3390/molecules28062543.

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Over the past decades, 2(5H)-furanone derivatives have been extensively studied because of their promising ability to prevent the biofilm formation by various pathogenic bacteria. Here, we report the synthesis of a series of optically active sulfur-containing 2(5H)-furanone derivatives and characterize their biological activity. Novel thioethers were obtained by an interaction of stereochemically pure 5-(l)-menthyloxy- or 5-(l)-bornyloxy-2(5H)-furanones with aromatic thiols under basic conditions. Subsequent thioethers oxidation by an excess of hydrogen peroxide in acetic acid resulted in the

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20

Desmaele, Didier, Jean d'Angelo, and Claudette Bois. "Asymmetric synthesis of furanones." Tetrahedron: Asymmetry 1, no. 11 (1990): 759–62. http://dx.doi.org/10.1016/s0957-4166(00)80438-3.

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21

Srinivasan, Sujatha, Jörgen Östling, Timothy Charlton, Rocky de Nys, Kathy Takayama, and Staffan Kjelleberg. "Extracellular Signal Molecule(s) Involved in the Carbon Starvation Response of Marine Vibrio sp. Strain S14." Journal of Bacteriology 180, no. 2 (1998): 201–9. http://dx.doi.org/10.1128/jb.180.2.201-209.1998.

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ABSTRACT The role of exogenous metabolites as putative signal molecules mediating and/or regulating the carbon starvation adaptation program inVibrio sp. strain S14 was investigated. Addition of the stationary-phase supernatant extract (SSE) of Vibrio sp. strain S14 to logarithmic-phase cells resulted in a significant number of carbon starvation-induced proteins being up-regulated. Halogenated furanones, putative antagonists of acylated homoserine lactones (AHLs), inhibited the synthesis of proteins specifically induced upon carbon starvation. The effect of the furanone was the opposite of tha

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22

Khabibrakhmanova, A. M., R. G. Faizova, D. P. Gerasimova, et al. "Optically Active Sulfoxides from 2(5H)-Furanone and Monoterpene Alcohols: Synthesis, Structure, and Antibacterial Activity." Uchenye Zapiski Kazanskogo Universiteta Seriya Estestvennye Nauki 166, no. 4 (2024): 563–89. http://dx.doi.org/10.26907/2542-064x.2024.4.563-589.

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A series of optically active 5(S)-(l-bornyloxy)- and 5(S)-(l-menthyloxy)-2(5H)-furanones with an arylthio group at the C(4) position of the γ-lactone ring was synthesized and studied for its oxidation reactions with various reagents. Novel 2(5H)-furanone sulfoxides were obtained as mixtures of two diastereoisomers through the oxidation of arylthioethers with m-chloroperbenzoic acid (m-СРВА) or hydrogen peroxide in acetic acid. Individual stereoisomers of these sulfoxides were isolated using recrystallization and high-performance liquid chromatography (HPLC) and characterized by IR and NMR spec

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23

Litera, Jaroslav, Miloš Buděšínský, Ján Urban, and Milan Souček. "Peptide Inhibitors of Aspartic Proteinases with Hydroxyethylene Isostere Replacement of Peptide Bond. I. Preparation of Four Diastereoisomeric (2R or 2S,4R or 4S,5S)-2-Benzyl-5-[(tert-butoxycarbonyl)amino]-4-hydroxy-6-phenylhexanoic Acids." Collection of Czechoslovak Chemical Communications 63, no. 2 (1998): 231–44. http://dx.doi.org/10.1135/cccc19980231.

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By two separate routes were prepared four diastereoisomers of (2R or 2S,5R or 5S)-3-benzyl-5-{(1S)- [(tert-butoxycarbonyl)amino]-2-phenylethyl}tetrahydrofuran-2-ones (11, 12, 17 and 18). Since the furanones were derived from (S)-phenylalanine, absolute configurations of all chiral carbon atoms could be deduced from their 1H NMR spectra. The furanones were easily hydrolyzed to four (2R or 2S,4R or 4S,5S)-2-benzyl-5- [(tert-butoxycarbonyl)amino]-4-hydroxy-6-phenylbutanoic acids (20-23), hydroxyethylene isosteres of Phe-Phe peptide bond.

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24

Oelgemöller, Michael, Norbert Hoffmann, and Oksana Shvydkiv. "From 'Lab & Light on a Chip' to Parallel Microflow Photochemistry." Australian Journal of Chemistry 67, no. 3 (2014): 337. http://dx.doi.org/10.1071/ch13591.

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Continuous-flow microreactors offer major advantages for photochemical applications. This mini-review summarizes the technological development of microflow devices in the Applied and Green Photochemistry Group at James Cook University, and its associates, from fixed microchips for microscale synthesis to flexible multicapillary systems for parallel photochemistry. Whereas the enclosed microchip offered high space–time-yields, the open capillary-type reactor showed a greater potential for further modifications. Consequently, a 10-microcapillary reactor was constructed and used successfully for

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25

Anis’kova, T. V., I. E. Kamneva, and A. Yu Egorova. "Synthesis of arylmethylidene(ethylidene)furanones." Review Journal of Chemistry 4, no. 3 (2014): 204–20. http://dx.doi.org/10.1134/s2079978014030017.

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26

Xu, Zhi Ping, Chup Yew Mok, Wee Shong Chin, Hsing Hua Huang, Sheng Li, and Wei Huang. "Interconversion and decomposition of furanones." Journal of the Chemical Society, Perkin Transactions 2, no. 4 (1999): 725–30. http://dx.doi.org/10.1039/a810028d.

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27

Ramadan, Sayed K., Wael S. I. Abou-Elmagd, and Ahmed I. Hashem. "Reactions of 2(3H)-furanones." Synthetic Communications 49, no. 22 (2019): 3031–57. http://dx.doi.org/10.1080/00397911.2019.1647441.

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28

Saalfrank, R. W., W. Hafner, J. Markmann, and H. J. Bestmann. "Convenient synthesis of 5-alkylidene-2(5H)-furanones,2(5H)-furanones and 2-ethoxyfurans." Tetrahedron 44, no. 16 (1988): 5095–100. http://dx.doi.org/10.1016/s0040-4020(01)86013-0.

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29

Wu, Xiangfei, Seiji Shirakawa, and Keiji Maruoka. "Efficient asymmetric synthesis of spiro-2(3H)-furanones via phase-transfer-catalyzed alkynylation." Org. Biomol. Chem. 12, no. 29 (2014): 5388–92. http://dx.doi.org/10.1039/c4ob00969j.

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30

Bai, Zhushuang, Ling Ji, Zemei Ge, Xin Wang, and Runtao Li. "Asymmetric Michael addition reactions of nitroalkanes to 2-furanones catalyzed by bifunctional thiourea catalysts." Organic & Biomolecular Chemistry 13, no. 19 (2015): 5363–66. http://dx.doi.org/10.1039/c5ob00708a.

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31

Veena, Joshi, Prakash S., and P. Chamoli R. "Some new furanones : Synthesis, characterisation and antimicrobial activity." Journal of Indian Chemical Society Vol. 87, Mar 2010 (2010): 373–78. https://doi.org/10.5281/zenodo.5779167.

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Depanment of Chemistry, HNB Garhwal University Campus, Badshahithaul-249 199, Tehri Garhwal, Uttarakhand, India <em>E-mail:</em> drrpchamoli@rediffmail.com Department of Chemistry, Govt. Post-Graduate College, Kotdwara-246 149, Uttarakhand, India <em>Manuscript received 11 November 2008, revised 24 April 2009, accepted 7 August 2009</em> The synthesis of some new furanones starting from three \(\gamma\)-keto acids, β-(3 4-dlmethylbenzoyl),aerylic acid and β-(2,5-dimethylbenzoyl)aerylic acid is deseribed. Each acid is condensed with various phenols useing catalytic sulphuric acid

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32

Khabibrakhmanova, A. M., E. S. Rabbanieva, D. P. Gerasimova, O. A. Lodochnikova, L. Z. Latypova, and A. R. Kurbangalieva. "Oxidation of Chiral 2(5H)-Furanone Bis-Thioethers to Disulfoxides." Uchenye Zapiski Kazanskogo Universiteta. Seriya Estestvennye Nauki 165, no. 1 (2023): 133–48. http://dx.doi.org/10.26907/2542-064x.2023.1.133-148.

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Novel disulfinyl derivatives based on 3,4-dichloro-2(5H)-furanone, aliphatic dithiols, and monoterpene alcohols were synthesized. Chiral bis-thioethers in the molecules of which the dithiol fragment links two five-membered cycles at C4 atoms were obtained in the reactions of 5(S)-(l-menthyloxy)- and 5(S)-(l-bornyloxy)-2(5H)-furanones with ethane-1,2-dithiol and propane-1,3-dithiol in acetone in basic medium. The action of an excess of m-chloroperoxybenzoic acid (2.0–3.2 equiv.) on bis-thioethers led to the formation of the corresponding mono- and disulfoxides bearing l-menthol or l-borneol fra

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33

Janecki, Tomasz, and Edyta Błaszczyk. "A Convenient Synthesis of 3-Alkylidenetetrahydro-2-furanones from 3-Diethoxyphosphoryl-2,5-dihydro-2-furanones." Synthesis 2001, no. 03 (2001): 0403–8. http://dx.doi.org/10.1055/s-2001-11432.

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34

Hollingworth, Gregory J., and J. B. Sweeney. "Preparation and reactions of 3- and 4-tributylstannyl-2-(5H)-furanones: Preparation of aryl furanones." Tetrahedron Letters 33, no. 46 (1992): 7049–52. http://dx.doi.org/10.1016/s0040-4039(00)60930-9.

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35

Matsuda, Takanori, Yuki Tabata, and Hirotsugu Suzuki. "Silver-catalyzed ring-opening [3+2] annulation of cyclopropenones with amides." New Journal of Chemistry 42, no. 23 (2018): 19178–82. http://dx.doi.org/10.1039/c8nj04579h.

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36

Yang, Kai, Juan-Juan Gao, Shi-He Luo, et al. "Quick construction of a C–N bond from arylsulfonyl hydrazides and Csp2–X compounds promoted by DMAP at room temperature." RSC Advances 9, no. 35 (2019): 19917–23. http://dx.doi.org/10.1039/c9ra03403j.

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37

Muthusamy, Gopinathan, and Sunil V. Pansare. "Stereoselective synthesis of E-3-(arylmethylidene)-5-(alkyl/aryl)-2(3H)-furanones by sequential hydroacyloxylation-Mizoroki–Heck reactions of iodoalkynes." Organic & Biomolecular Chemistry 16, no. 42 (2018): 7971–83. http://dx.doi.org/10.1039/c8ob02063a.

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38

Zhou, Jing, Lijuan Bai, Guojuan Liang, et al. "Organocatalytic asymmetric domino Michael/O-alkylation reaction for the construction of succinimide substituted 3(2H)-furanones catalyzed by quinine." RSC Advances 7, no. 63 (2017): 39885–88. http://dx.doi.org/10.1039/c7ra07317h.

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39

Krayushkin, M. M., D. V. Pashchenko, B. V. Lichitskii, T. M. Valova, Yu P. Strokach, and V. A. Barachevskii. "Synthesis and properties of dihetaryl-substituted furanones. Synthesis of photochromic dithienylethenes containing a furanone bridging fragment." Russian Journal of Organic Chemistry 42, no. 12 (2006): 1816–21. http://dx.doi.org/10.1134/s1070428006120104.

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Oelgemöller, Michael, and Norbert Hoffmann. "Photochemically induced radical reactions with furanones." Pure and Applied Chemistry 87, no. 6 (2015): 569–82. http://dx.doi.org/10.1515/pac-2014-0902.

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AbstractRadicals are easily generated via hydrogen transfer form secondary alcohols or tertiary amines using photochemical sensitization with ketones. They can subsequently add to the electron deficient double bond of furanones. The addition of the alcohols is particularly efficient. Therefore, this reaction was used to characterize and to compare the efficiency of different photochemical continuous flow microreactors. A range of micro-structured reactors were tested and their performances evaluated. The enclosed microchip enabled high space-time-yields but its microscopic dimensions limited i

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Boeykens, Marc, and Norbert De Kimpe. "Synthesis of 4,4-Dialkyltetrahydro-3-furanones." Synthesis 1992, no. 11 (1992): 1109–12. http://dx.doi.org/10.1055/s-1992-26316.

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Panda, Niranjan, and Dinesh K. Nayak. "Facile synthesis of 3(2H)-furanones." Monatshefte für Chemie - Chemical Monthly 149, no. 6 (2018): 1093–100. http://dx.doi.org/10.1007/s00706-018-2152-8.

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Muthusamy, S., J. Krishnamurthi, and E. Suresh. "Chemodivergent Formation of Furanones and Piperidines." Synfacts 2007, no. 1 (2007): 0061. http://dx.doi.org/10.1055/s-2006-955737.

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DESMAELE, D., J. D'ANGELO, and C. BOIS. "ChemInform Abstract: Asymmetric Synthesis of Furanones." ChemInform 22, no. 12 (2010): no. http://dx.doi.org/10.1002/chin.199112178.

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HOLLINGWORTH, G. J., and J. B. SWEENEY. "ChemInform Abstract: Preparation and Reactions of 3- and 4-Tributylstannyl-2-(5H)-furanones: Preparation of Aryl Furanones." ChemInform 24, no. 15 (2010): no. http://dx.doi.org/10.1002/chin.199315171.

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Janecki, Tomasz, and Edyta Blaszczyk. "ChemInform Abstract: A Convenient Synthesis of 3-Alkylidenetetrahydro-2-furanones from 3-Diethoxyphosphoryl-2,5-dihydro-2-furanones." ChemInform 32, no. 28 (2010): no. http://dx.doi.org/10.1002/chin.200128114.

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Ni, Hangcheng, Yu Li, Chaoming Li, and Zhenxiang Liu. "Light-promoted borylation and lactonization of propargyl acetates using NHC-borane." RSC Advances 15, no. 6 (2025): 4652–56. https://doi.org/10.1039/d4ra08656b.

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In the absence of photoredox catalyst, we achieved radical borylation and lactonization of propargyl acetates under light irradiation using N-heterocyclic carbene borane, leading to the synthesis of substituted 4-(NHC-boryl)-2(5H)-furanones.

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48

Talero, Alexánder, та Antonio Burtoloso. "Sharpless Asymmetric Dihydroxylation on α,β-Unsaturated Diazoketones: A New Entry for the Synthesis of Disubstituted Furanones". Synlett 28, № 14 (2017): 1748–52. http://dx.doi.org/10.1055/s-0036-1590977.

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The synthesis of enantiomerically pure 4,5-disubstituted 2-furanones is accomplished in three steps from aldehydes. The steps involve a highly enantioselective Sharpless asymmetric dihydroxylation of α,β-unsaturated diazoketones, followed by a photochemical Wolff rearrangement.

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Wolff, Steven, and William C. Agosta. "Novel photochemical reactions of 3(2H)-furanones." Journal of Organic Chemistry 50, no. 24 (1985): 4707–11. http://dx.doi.org/10.1021/jo00224a009.

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KAMETANI, TETSUJI, TADASHI KATOH, MASAYOSHI TSUBUKI, and TOSHIO HONDA. "Synthesis of 4-alkyl-2(5H)-furanones." CHEMICAL & PHARMACEUTICAL BULLETIN 33, no. 1 (1985): 61–66. http://dx.doi.org/10.1248/cpb.33.61.

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