Academic literature on the topic 'Gap junctions'

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Journal articles on the topic "Gap junctions"

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Spray, D. C., R. L. White, F. Mazet, and M. V. Bennett. "Regulation of gap junctional conductance." American Journal of Physiology-Heart and Circulatory Physiology 248, no. 6 (June 1, 1985): H753—H764. http://dx.doi.org/10.1152/ajpheart.1985.248.6.h753.

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Gap junctional conductance is regulated by the number of channels between coupled cells (the balance between formation and loss of these channels) and by the fraction of these channels that are open (gating mechanisms). A variety of treatments are known to affect junction formation. Adenosine 3',5'-cyclic monophosphate (cAMP) is involved in some cases, and protein synthesis may be required but precursor molecules can also exist. Junction removal occurs both by dispersion of particles and by internalization of junctional membrane. Factors promoting removal are not well understood. A variety of
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Lo, W. K., and T. S. Reese. "Multiple structural types of gap junctions in mouse lens." Journal of Cell Science 106, no. 1 (September 1, 1993): 227–35. http://dx.doi.org/10.1242/jcs.106.1.227.

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Gap junctions in the epithelium and superficial fiber cells from young mice were examined in lenses prepared by rapid-freezing, and processed for freeze-substitution and freeze-fracture electron microscopy. There appeared to be three structural types of gap junction: one type between epithelial cells and two types between fiber cells. Epithelial gap junctions seen by freeze-substitution were approximately 20 nm thick and consistently associated with layers of dense material lying along both cytoplasmic surfaces. Fiber gap junctions, in contrast, were 15–16 nm (type 1) or 17–18 nm thick (type 2
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Naus, Christian CG. "Gap junctions and tumour progression." Canadian Journal of Physiology and Pharmacology 80, no. 2 (February 1, 2002): 136–41. http://dx.doi.org/10.1139/y02-009.

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Gap junctional intercellular communication has been implicated in growth control and differentiation. The mechanisms by which connexins, the gap junction proteins, act as tumor suppressors are unclear. In this review, several different mechanisms are considered. Since transformation results in a loss of the differentiated state, one mechanism by which gap junctions may control tumour progression is to promote or enhance differentiation. Processes of differentiation and growth control are mediated at the genetic level. Thus, an alternative or complimentary mechanism of tumour suppression could
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Churchill, D., S. Coodin, R. R. Shivers, and S. Caveney. "Rapid de novo formation of gap junctions between insect hemocytes in vitro: a freeze-fracture, dye- transfer and patch-clamp study." Journal of Cell Science 104, no. 3 (March 1, 1993): 763–72. http://dx.doi.org/10.1242/jcs.104.3.763.

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Gap junctions form between insect hemocytes (blood cells) when they encapsulate foreign objects in the hemocoel (body cavity). In this study we show that hemocytes from cockroach (Periplaneta americana) form gap-junctions rapidly in vitro. Freeze-fracture replicas of hemocyte aggregates fixed 5 minutes after bleeding contain gap-junctional plaques. Dye passage was detected between carboxyfluorescein diacetate- labelled and unlabelled hemocytes within 3 minutes of bleeding, when the cells made contact as they flattened rapidly onto coverslips. When double whole-cell voltage-clamp was used to me
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Warner, Anne E. "The role of gap junctions in amphibian development." Development 89, Supplement (November 1, 1985): 365–80. http://dx.doi.org/10.1242/dev.89.supplement.365.

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The possibility that communication through gap junctions may be important during embryonic development has often been raised since gap junctions were first described between early embryonic cells. It is now known that this direct cell-to-cell communication pathway disappears between groups of embryonic cells with different developmental fates as the embryo progresses through development, suggesting that transfer through the gap junctional pathway may play some part in controlling events during development. Supportive evidence for a role for gap junctions comes from experiments demonstrating th
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Rook, M. B., A. C. van Ginneken, B. de Jonge, A. el Aoumari, D. Gros, and H. J. Jongsma. "Differences in gap junction channels between cardiac myocytes, fibroblasts, and heterologous pairs." American Journal of Physiology-Cell Physiology 263, no. 5 (November 1, 1992): C959—C977. http://dx.doi.org/10.1152/ajpcell.1992.263.5.c959.

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Cultures of neonatal rat heart cells contain predominantly myocytes and fibroblastic cells. Most abundant are groups of synchronously contracting myocytes, which are electrically well coupled through large gap junctions. Cardiac fibroblasts may be electrically coupled to each other and to adjacent myocytes, be it with low intercellular conductances. Nevertheless, synchronously beating myocytes interconnected via a fibroblast were present, demonstrating that nonexcitable cardiac cells are capable of passive impulse conduction. In fibroblast pairs as well as in myocyte-fibroblast cell pairs, no
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Verheule, Sander, Marjan J. A. van Kempen, Sjoerd Postma, Martin B. Rook, and Habo J. Jongsma. "Gap junctions in the rabbit sinoatrial node." American Journal of Physiology-Heart and Circulatory Physiology 280, no. 5 (May 1, 2001): H2103—H2115. http://dx.doi.org/10.1152/ajpheart.2001.280.5.h2103.

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In comparison to the cellular basis of pacemaking, the electrical interactions mediating synchronization and conduction in the sinoatrial node are poorly understood. Therefore, we have taken a combined immunohistochemical and electrophysiological approach to characterize gap junctions in the nodal area. We report that the pacemaker myocytes in the center of the rabbit sinoatrial node express the gap junction proteins connexin (Cx)40 and Cx46. In the periphery of the node, strands of pacemaker myocytes expressing Cx43 intermingle with strands expressing Cx40 and Cx46. Biophysical properties of
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Boitano, Scott, Zeenat Safdar, Donald G. Welsh, Jahar Bhattacharya, and Michael Koval. "Cell-cell interactions in regulating lung function." American Journal of Physiology-Lung Cellular and Molecular Physiology 287, no. 3 (September 2004): L455—L459. http://dx.doi.org/10.1152/ajplung.00172.2004.

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Tight junction barrier formation and gap junctional communication are two functions directly attributable to cell-cell contact sites. Epithelial and endothelial tight junctions are critical elements of the permeability barrier required to maintain discrete compartments in the lung. On the other hand, gap junctions enable a tissue to act as a cohesive unit by permitting metabolic coupling and enabling the direct transmission of small cytosolic signaling molecules from one cell to another. These components do not act in isolation since other junctional elements, such as adherens junctions, help
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FitzGerald, PG. "Gap junction Heterogeneity in Liver, Heart, and Lens." Physiology 3, no. 5 (October 1, 1988): 206–11. http://dx.doi.org/10.1152/physiologyonline.1988.3.5.206.

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Gap junctions are nearly ubiquitous structures that ionically and metabolically couple adjacent cells. Molecular analysis of junctional proteins is establishing the presence of families of unique but homologous junctional proteins, opening the door to an explanation of tissue specificity in gap junction structure and function.
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Ko, Kevin, Pamela Arora, Wilson Lee, and Christopher McCulloch. "Biochemical and functional characterization of intercellular adhesion and gap junctions in fibroblasts." American Journal of Physiology-Cell Physiology 279, no. 1 (July 1, 2000): C147—C157. http://dx.doi.org/10.1152/ajpcell.2000.279.1.c147.

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Despite their significance in wound healing, little is known about the molecular determinants of cell-to-cell adhesion and gap junctional communication in fibroblasts. We characterized intercellular adherens junctions and gap junctions in human gingival fibroblasts (HGFs) using a novel model. Calcein-labeled donor cells in suspension were added onto an established, Texas red dextran (10 kDa)-labeled acceptor cell monolayer. Cell-to-cell adhesion required Ca2+ and was >30-fold stronger than cell-to-fibronectin adhesion at 15 min. Electron micrographs showed rapid formation of adherens juncti
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Dissertations / Theses on the topic "Gap junctions"

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Sheela, Thomas Vinaya. "Regulation of Connexin40 Gap Junctions." Digital Archive @ GSU, 2008. http://digitalarchive.gsu.edu/biology_diss/55.

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Gap junctions provide direct electrical and biochemical communication between cardiomyocytes in the heart. Connexin40 (Cx40) is the major connexin in the atria of the heart and little is known regarding its regulation. Thus, the goal was to investigate the regulation of Cx40 in both physiological and pathophysiological conditions. The first objective of this thesis was to determine whether Cx40 gap junctions were regulated by â-adrenergic receptor activation. Cx40 has previously been shown to be acutely activated by cAMP, this cAMP-induced increase in Cx40-mediated cell-to-cell dye transfer ha
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Carolan, E. J. "Gap junctions in lymphocyte ontogeny." Thesis, University of Glasgow, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233181.

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Nishimura, Tamiko. "Gap junctions in early human placental development." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ63198.pdf.

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Ko, Yu-Shien. "Connexin heterogeneity in vascular cell gap junctions." Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393781.

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Pintsch, Monika. "Cx37 abhängige Calciumsignalausbreitung durch myoendotheliale Gap Junctions." Diss., Ludwig-Maximilians-Universität München, 2015. http://nbn-resolving.de/urn:nbn:de:bvb:19-182614.

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Eine effektive Regulation der Gewebedurchblutung erfordert eine Koordination der Reaktion einzelner Gefäßzellen bzw. verschiedener Gefäßabschnitte. Der zur Koordination erforderliche interzelluläre Signalaustausch kann zumindest teilweise über Gap Junction-Kanäle erfolgen, die als interzelluläre Verbindungen den Austausch von elektrischen und chemischen Signalstoffen zwischen benachbarten Zellen ermöglichen. Dieser Austausch kann über die Modulation der Permeabilität von Gap Junction-Kanälen reguliert werden. Aus Untersuchungen an Modellzellen (HeLA-Zellen) war bereits bekannt dass NO eine sol
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Rahman, Salman. "Biochemical and immunological studies on gap junctions." Thesis, University College London (University of London), 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266786.

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Kalapothakis, Evanguedes. "Expression and biomolecular assembly of gap junctions." Thesis, Open University, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.332822.

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Calkins, Travis L. "Gap Junctions in the Mosquito, Aedes aegypti." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu149217328492135.

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Gakhar, Gunjan. "Role of gap junctions in breast cancer." Diss., Manhattan, Kan. : Kansas State University, 2009. http://hdl.handle.net/2097/2228.

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Moore, Lisa Karen. "Regulation of gap junctions in vascular smooth muscle." Diss., The University of Arizona, 1993. http://hdl.handle.net/10150/186240.

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Gap junctions form low resistance pathways between neighboring cells and thereby provide for coordination of tissue function. In vascular smooth muscle these channels are believed to be important in maintenance of and coordination of changes in vessel tone. In this study we demonstrate that vascular smooth muscle cells from vessels of different origin and species differ in the connexin protein expressed as well as in the size of the channel formed by these proteins. We have shown that pig coronary and rat mesentery express mRNA for Cx43 and exhibit a single channel conductance of 60 or 80 pS r
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Books on the topic "Gap junctions"

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E, Hall J., Zampighi G, and Davis R. M, eds. Gap junctions. Amsterdam: Elsevier, 1993.

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L, Hertzberg Elliot, ed. Gap junctions. Stamford, Conn: Jai Press, 2000.

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Bennett, Michael V. L. 1931-, Spray David C, and Cold Spring Harbor Laboratory, eds. Gap junctions. Cold Spring Harbor, N.Y: Cold Spring Harbor Laboratory, 1985.

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International Gap Junction Conference (8th 1997 Key Largo, Fla.). Gap junctions: Proceedings of the 8th International Gap Junction Conference, Key Largo, Florida. Amsterdam: IOS Press, 1998.

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Y, Kanno, and International Meeting on Gap Junctions (1993 : Hiroshima-shi, Japan), eds. Intercellular communication through gap junctions. Amsterdam: Elsevier, 1995.

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1930-, Sperelakis Nick, and Cole William C. 1955-, eds. Cell interactions and gap junctions. Boca Raton, Fla: CRC Press, 1989.

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Winterhager, Elke, ed. Gap Junctions in Development and Disease. Berlin, Heidelberg: Springer Berlin Heidelberg, 2005. http://dx.doi.org/10.1007/3-540-28621-7.

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Spray, David C., and Rolf Dermietzel. Gap Junctions in the Nervous System. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-662-21935-5.

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C, Spray David, and Dermietzel Rolf, eds. Gap junctions in the nervous system. New York: Chapman & Hall, 1996.

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Janssen-Timmen, Uwe. Immunchemische Charakterisierung von Gap Junctions in Säugetiergeweben. [s.l.]: [s.n.], 1986.

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Book chapters on the topic "Gap junctions"

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Börgers, Christoph. "Gap Junctions." In An Introduction to Modeling Neuronal Dynamics, 165–73. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-51171-9_21.

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Alonso, Angel. "Gap Junctions." In Encyclopedia of Cancer, 1–3. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-27841-9_2325-2.

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Churko, Jared M., and Dale W. Laird. "Gap Junctions." In Cellular Domains, 339–47. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118015759.ch20.

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Wagner, Peter, Frank C. Mooren, Hidde J. Haisma, Stephen H. Day, Alun G. Williams, Julius Bogomolovas, Henk Granzier, et al. "Gap Junctions." In Encyclopedia of Exercise Medicine in Health and Disease, 351. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-29807-6_2424.

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Alonso, Angel. "Gap Junctions." In Encyclopedia of Cancer, 1843–44. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-46875-3_2325.

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Alonso, Angel. "Gap Junctions." In Encyclopedia of Cancer, 1502–3. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-16483-5_2325.

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Pavelka, Margit, and Jürgen Roth. "Tight Junctions and Gap Junctions." In Functional Ultrastructure, 168–69. Vienna: Springer Vienna, 2010. http://dx.doi.org/10.1007/978-3-211-99390-3_88.

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Duffy, Heather S., Alfredo G. Fort, and David C. Spray. "Cardiac Connexins: Genes to Nexus." In Cardiovascular Gap Junctions, 1–17. Basel: KARGER, 2006. http://dx.doi.org/10.1159/000092550.

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van Veen,, Toon A. B., Harold V. M. van Rijen, and Habo J. Jongsma. "Physiology of Cardiovascular Gap Junctions." In Cardiovascular Gap Junctions, 18–40. Basel: KARGER, 2006. http://dx.doi.org/10.1159/000092560.

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Giepmans, Ben N. G. "Role of Connexin43-Interacting Proteins at Gap Junctions." In Cardiovascular Gap Junctions, 41–56. Basel: KARGER, 2006. http://dx.doi.org/10.1159/000092561.

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Conference papers on the topic "Gap junctions"

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Bathany, Ce´dric, Thomas Suchyna, and Susan Z. Hua. "A Microfluidic Chip for Studying Intercellular Communication via Gap Junction Channels." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13135.

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Cells in tissues and organs coordinate their activities with each other, and this communication is mainly mediated by specialized channels, called Gap Junctions. To date, our understanding of specificity of reagents and extracellular stimuli to gap junctions is very limited. Existing techniques for gap junctions assay are tedious and not convenient. We have developed a microfluidic chip that is capable of detecting chemical diffusion across gap junctions, as well as screening reagents for specific gap junction channels.
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Calkins, Travis Lee. "Gap junctions and the mosquito blood meal." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.113636.

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Hejri, Farrokh, Mladen Veletić, and Ilangko Balasingham. "On the Cardiac Gap Junctions Channel Modeling." In NANOCOM '19: The Sixth Annual ACM International Conference on Nanoscale Computing and Communication. New York, NY, USA: ACM, 2019. http://dx.doi.org/10.1145/3345312.3345475.

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Wildie, Mark, Wayne Luk, Simon R. Schultz, Philip H. W. Leong, and Andreas K. Fidjeland. "Reconfigurable acceleration of neural models with gap junctions." In 2009 International Conference on Field-Programmable Technology (FPT). IEEE, 2009. http://dx.doi.org/10.1109/fpt.2009.5377639.

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Ienna, Antonio, Michele Migliore, and Cesare Valenti. "Visualization of Simulated Arrhythmias due to Gap Junctions." In CompSysTech'18: 19th International Conference on Computer Systems and Technologies. New York, NY, USA: ACM, 2018. http://dx.doi.org/10.1145/3274005.3274011.

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Appukuttan, Shailesh, Rohan Sathe, and Rohit Manchanda. "Modular approach to modeling homotypic and heterotypic gap junctions." In 2015 IEEE 5th International Conference on Computational Advances in Bio and Medical Sciences (ICCABS). IEEE, 2015. http://dx.doi.org/10.1109/iccabs.2015.7344707.

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Nguyen, M. Chung, V. Hung Nguyen, P. Dollfus, and H. Viet Nguyen. "Conduction gap of strained/unstrained graphene junctions: Direction dependence." In 2014 International Workshop on Computational Electronics (IWCE). IEEE, 2014. http://dx.doi.org/10.1109/iwce.2014.6865868.

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Loginova, Nadezhda, Nikola Panov, Nikolai Kositsyn, and Mikhail Svinov. "THE ROLE OF GAP JUNCTIONS IN THE CEREBRAL ISCHEMIA DEVELOPMENT." In XIV International interdisciplinary congress "Neuroscience for Medicine and Psychology". LLC MAKS Press, 2018. http://dx.doi.org/10.29003/m188.sudak.ns2018-14/305.

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Krishnan, J., V. S. Chakravarthy, and S. Radhakrishnan. "On the role of gap junctions in cardiac memory effect." In Computers in Cardiology, 2005. IEEE, 2005. http://dx.doi.org/10.1109/cic.2005.1588020.

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Li, L., G. A. Gusarova, M. N. Islam, and J. Bhattacharya. "Siglec-F Determines Lung Immunity Through Regulation of Macrophage Gap Junctions." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5832.

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Reports on the topic "Gap junctions"

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Chen, J., J. F. Zasadzinski, K. E. Gray, J. L. Wagner, D. G. Hinks, K. Kouznetsov, and L. Coffey. BCS-like gap structure of HgBa{sub 2}CuO{sub 4+{delta}} tunnel junctions. Office of Scientific and Technical Information (OSTI), December 1994. http://dx.doi.org/10.2172/10104581.

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Myers, Janette. Application of Single Particle Electron Microscopy to Native Lens Gap Junctions and Intrinsically Disordered Signaling Complexes. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.6884.

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Donahue, Henry J. Gap Junctional Intercellular Communication and Breast Cancer Metastasis to Bone. Fort Belvoir, VA: Defense Technical Information Center, October 2001. http://dx.doi.org/10.21236/ada405244.

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Trosko, James E. The Role of Chemical Inhibition of Gap-Junctional Intercellular Communication in Toxicology. Fort Belvoir, VA: Defense Technical Information Center, March 1989. http://dx.doi.org/10.21236/ada207130.

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Trosko, James E. The Role of Chemical Inhibition of Gap-Junctional Intercellular Communication in Toxicology. Fort Belvoir, VA: Defense Technical Information Center, March 1991. http://dx.doi.org/10.21236/ada241465.

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Trosko, James E. The Role of Chemical Inhibition of Gap-Junctional Intercellular Communication in Toxicology. Fort Belvoir, VA: Defense Technical Information Center, March 1990. http://dx.doi.org/10.21236/ada221480.

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Guha, S. Research on high-efficiency, multi-gap, multi-junction amorphous silicon-based alloy thin-film solar cells. Office of Scientific and Technical Information (OSTI), October 1989. http://dx.doi.org/10.2172/5164953.

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Raymond, Kara, Laura Palacios, and Evan Gwilliam. Status of climate and water resources at Big Bend National Park: Water year 2019. Edited by Tani Hubbard. National Park Service, September 2022. http://dx.doi.org/10.36967/2294267.

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Climate and hydrology are major drivers of ecosystem structure and function, particularly in arid and semi-arid ecosystems. Understanding changes in climate, groundwater, streamflow, and water quality is central to assessing the condition of park resources. This report combines data collected on climate, groundwater, and springs at Big Bend National Park (NP) to provide an integrated look at climate and water conditions during water year (WY) 2019 (October 2018–September 2019). However, this report does not address the Rio Grande or its tributaries. Annual precipitation was higher than normal
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Madan, A. High Efficiency Narrow Gap and Tandem Junction Devices: Final Technical Report, 1 May 2002--31 October 2004. Office of Scientific and Technical Information (OSTI), March 2005. http://dx.doi.org/10.2172/15011482.

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Gisladottir, Viktoria, Amanda Kolker, Zachary Zody, and Ian Warren. Phase I geothermal opportunities assessment of the Delta Junction area, Alaska. Engineer Research and Development Center (U.S.), October 2023. http://dx.doi.org/10.21079/11681/47766.

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To enhance energy resilience at military installations in Interior Alaska, we are exploring geothermal energy, which harvests Earth’s heat to provide thermal energy, electricity, or both. Parts of Interior Alaska have high subsurface heat flow, likely related to high-heat-producing granites. While electric load is usually the focus of energy resilience; in cold regions, the thermal load dominates energy demand, and operations can be sensitive to it. A local geothermal energy source enhances energy resilience by providing baseload energy and lessening supply chain demand. Geothermal energy tech
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