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Dissertations / Theses on the topic 'Gastroenterological diseases'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

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1

Шевченко, Володимир Володимирович, Владимир Владимирович Шевченко, Volodymyr Volodymyrovych Shevchenko та Т. С. Коваленко. "Особливості ЕКГ при функціональних захворюваннях травного каналу у дітей". Thesis, Видавництво СумДУ, 2009. http://essuir.sumdu.edu.ua/handle/123456789/11291.

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Borja, Ezana Sandrina Almada Fernandes de. "Inspiratory pressure maximum and its relationship with symptoms and factors associated with reflux disease gastroesophageal." Universidade Federal do CearÃ, 2015. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16082.

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CoordenaÃÃo de AperfeÃoamento de Pessoal de NÃvel Superior<br>The gastroesophageal reflux disease is the return of gastric contents through the lower esophageal sphincter regardless of etiology, manifesting itself by symptoms (typical or atypical) or tissue damage. The diaphragm is the main respiratory muscle and its crural part one of the fundamental components of the antireflux barrier. Contractions of this are related to changes in pressure of the gastroesophageal junction that are usually related to breathing. Studies show evidence of diaphragmatic weakness in gastroesophageal reflux disea

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De, Salvo Carlo <1975&gt. "Pathogenic role of IL-33-mediated eosinophil infiltration and function in experimental inflammatory bowel disease." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amsdottorato.unibo.it/5286/1/De_Salvo_Carlo_tesi.pdf.

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IL-33/ST2 axis is known to promote Th2 immune responses and has been linked to several autoimmune and inflammatory disorders, including inflammatory bowel disease (IBD), and recent evidences show that it can regulate eosinophils (EOS) infiltration and function. Based also on the well documented relationship between EOS and IBD, we assessed the role of IL-33-mediated eosinophilia and ileal inflammation in SAMP1/YitFc (SAMP) murine model of Th1/Th2 chronic enteritis, and we found that IL-33 is related to inflammation progression and EOS infiltration as well as IL-5 and eotaxins increase. Adminis

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De, Salvo Carlo <1975&gt. "Pathogenic role of IL-33-mediated eosinophil infiltration and function in experimental inflammatory bowel disease." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amsdottorato.unibo.it/5286/.

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IL-33/ST2 axis is known to promote Th2 immune responses and has been linked to several autoimmune and inflammatory disorders, including inflammatory bowel disease (IBD), and recent evidences show that it can regulate eosinophils (EOS) infiltration and function. Based also on the well documented relationship between EOS and IBD, we assessed the role of IL-33-mediated eosinophilia and ileal inflammation in SAMP1/YitFc (SAMP) murine model of Th1/Th2 chronic enteritis, and we found that IL-33 is related to inflammation progression and EOS infiltration as well as IL-5 and eotaxins increase. Adminis

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Roda, Giulia <1980&gt. "Development of new therapeutic approaches in the treatments of Inflammatory Bowel Diseases: functional food and nutraceuticals vs synthetic peptides based vaccines." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amsdottorato.unibo.it/5362/1/roda_giulia_tesi.pdf.

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Inflammatory Bowel Diseases (IBD) are intestinal chronic relapsing diseases which ethiopathogenesis remains uncertain. Several group have attempted to study the role of factors involved such as genetic susceptibility, environmental factors such as smoke, diet, sex, immunological factors as well as the microbioma. None of the treatments available satisfy several criteria at the same time such as safety, long-term remission, histopatological healing, and specificity. We used two different approaches for the development of new therapeutic treatment for Inflammatory Bowel Disease. The first is

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Roda, Giulia <1980&gt. "Development of new therapeutic approaches in the treatments of Inflammatory Bowel Diseases: functional food and nutraceuticals vs synthetic peptides based vaccines." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amsdottorato.unibo.it/5362/.

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Inflammatory Bowel Diseases (IBD) are intestinal chronic relapsing diseases which ethiopathogenesis remains uncertain. Several group have attempted to study the role of factors involved such as genetic susceptibility, environmental factors such as smoke, diet, sex, immunological factors as well as the microbioma. None of the treatments available satisfy several criteria at the same time such as safety, long-term remission, histopatological healing, and specificity. We used two different approaches for the development of new therapeutic treatment for Inflammatory Bowel Disease. The first is

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Tomba, C. "PERSONALIZED MANAGEMENT OF CELIAC DISEASE: RISK STRATIFICATION AND NOVEL STRATEGIES FOR COMPLICATED PATIENTS." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/254987.

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SUMMARY Background. Celiac disease is a widespread autoimmune disease diagnosed at increasing frequency. Celiac patients regularly attend medical services and present a benign course. The knowledge of clinical and biological factors predictive of malignant evolution is poor. Thus, management of such a large population of patients still lacks evidence-based criteria in order to target diagnostic strategies to the subgroup ”at-risk” to develop small bowel complications. Aim. To identify celiac patients’ characteristics associated to a higher probability of complicated course and to evaluate th

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Mitrev, Nikola. "Therapeutic drug monitoring guided anti-tumour necrosis factor therapy in inflammatory bowel disease (IBD): Gastroenterological Society of Australia (GESA)/ Australian IBD Association (AIBDA) consensus statements." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/17449.

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INTRODUCTION: Growing evidence supports the use of therapeutic drug monitoring (TDM) to guide anti-tumour necrosis factor (TNF) drug treatment among patients with inflammatory bowel disease (IBD). Currently, TDM for anti-TNF drugs is variably practiced by gastroenterologists in Australia. Our aim was to develop consensus statements for TDM of anti-TNF drugs in IBD that will be endorsed by the Australian IBD Association (AIBDA) of the Gastroenterological Society of Australia (GESA). METHODS: A consensus committee of 25 Australian and international experts was assembled. A systematic literature

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NINFOLE, ELISABETTA. "Involvement of autophagy in cholestatic liver diseases." Doctoral thesis, Università Politecnica delle Marche, 2022. https://hdl.handle.net/11566/298981.

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L'autofagia è un processo fisiologico di degradazione lisosomiale, essenziale per l'omeostasi cellulare e onnipresente in tutte le cellule eucariotiche. La deregolazione epatica dell'autofagia è stata descritta in diverse condizioni, dall'obesità al diabete e alle malattie colestatiche, mentre la stimolazione dell'autofagia sembra migliorare il danno epatico. Il progetto è focalizzato sull'identificazione di vie molecolari che si attivano durante il processo autofagico in risposta al danno del dotto biliare e se l'autofagia svolge un ruolo nella regolazione dei processi di invecchiamento cell

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MAESTRONI, ANNA MARIA. "DYSREGULATION OF INTESTINAL STEM CELLS IN CROHN'S DISEASE." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/621110.

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Riassunto Introduzione. Numerosi fattori, tra cui eventi immunitari, agenti ambientali tossici, predisposizione genetica e microbiota anormale svolgono un ruolo chiave nella patogenesi della malattia di Crohn, ma il principale meccanismo alla base è ancora oggetto di studio. L'omeostasi della mucosa intestinale si basa su un delicato equilibrio tra auto-rinnovamento e differenziazione, che è garantita dal ricambio delle cellule staminali intestinali all'interno delle cripte. Recenti studi suggeriscono che una differenziazione alterata delle cellule staminali intestinali (ISC) può facilit

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COLETTA, MARINA. "IMMUNOLOGIC PREDICTORS  OF RESPONSE TO VEDOLIZUMAB TREATMENT IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE: RESULTS OF A PHASE IV PROSPECTIVE INTERVENTIONAL TRIAL." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/666203.

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Objective: Vedolizumab (VDZ) is a monoclonal antibody directed against α4β7 integrin heterodimer, approved for patients with inflammatory bowel disease (IBD). This study aimed at identifying circulating and mucosal immunologic predictors of response in patients with active ulcerative colitis (UC) and Crohn’s disease (CD). Design: This is an explorative, prospective, phase IV interventional trial (Eudract n. 2015- 003270-32). Consecutive CD and UC patients received open-label VDZ at weeks 0, 2, 6 and 14. A week 10 infusion was performed in CD patients. Patients with clinical response at

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Medici, Valentina. "S-adenosylmethionine and methionine metabolism in Alcoholic Liver Disease (ALD)." Doctoral thesis, Università degli studi di Padova, 2009. http://hdl.handle.net/11577/3425617.

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BACKGROUND: Prior experimental studies found associations of alcoholism and alcoholic liver disease (ALD) with abnormal methionine metabolism. Aberrant methionine metabolism may play a central role in the pathogenesis of ALD. AIM: To establish profiles of plasma methionine metabolites in ALD patients compared to those found in healthy control subjects and alcoholics without clinical or biochemical evidence of liver disease, and to define the relationship of these profiles to clinical and pathological severity of ALD. PATIENTS AND METHODS: Serum levels of S-adenosylmethionine (SAM), S-adenosy

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BRANCHI, FEDERICA. "THE ROLE OF FLOW CYTOMETRY IN COMPLICATED CELIAC DISEASE." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/553600.

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Background Refractory celiac disease (RCD) is defined as persistence or recurrence of clinical symptoms of malabsorption and histologic signs of villous atrophy despite at least 1 year of strict adherence to a gluten-free diet. Two different entities of RCD have been described: RCD I shows a polyclonal pattern of intraepithelial lymphocytes (IEL), while in RCD II a monoclonal transformation of IEL can be identified (usually detected by means of TCR clonality analysis). Patients with RCD II have a poorer prognosis and a high risk of development of enteropathy-associated T-cell lymphoma (EATL),

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PELLEGRINO, GABRIELLA. "PHENOTYPIC AND FUNCTIONAL CHARACTERIZATION OF HUMAN NEUTROPHIL SUBSETS IN PATIENTS WITH COLORECTAL CANCER AND INFLAMMATORY BOWEL DISEASES." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/485079.

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Neutrophils play a critical role in the maintenance of intestinal homeostasis while, in pathological conditions, these cells, together with macrophages, T and B lymphocytes, infiltrate the lamina propria where they exert their functions. In murine models of intestinal inflammation and cancer, a change in neutrophils phenotype and its possible functional consequence has already been described while, in humans, there are limited data. Whether mucosal neutrophils play different functional roles in inflammatory bowel diseases (IBD) and colorectal cancer (CRC) is still debated. Here, we repor

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ROMEO, ANNA CLAUDIA. "Effectiveness and safety of biologics in pediatric inflammatory bowel disease: Real-life data from the Sicilian Network." Doctoral thesis, Università degli studi di Genova, 2023. https://hdl.handle.net/11567/1105880.

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ABSTRACT Introduction. The incidence and prevalence of pediatric inflammatory bowel disease (IBD) are rising worldwide, with a steep increase in children under 5 years of age. Compared to adult IBD, pediatric IBD presents with a more severe, aggressive phenotype and unique complications, notably growth impairment. The advent of anti–tumor necrosis factor (TNF) α agents has radically modified the management and disease course of IBD, resulting in greater remission and mucosal healing rates, fewer surgeries and hospitalizations, improved quality of life, and, notably for children, correction of

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IACUCCI, MARIETTA. "Survey regarding the use of adalimumab as maintenance therapy in Crohn’s disease in England and Ireland." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2010. http://hdl.handle.net/2108/1420.

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Introduction: Adalimumab is effective in inducing and maintaining response/remission in patients with Crohn’s Disease (CD) either naive to biological therapies or following secondary failure of infliximab. Aim: To present the first ‘real-life’ survey data from England and Ireland on the use of adalimumab. Method: A retrospective audit conducted by a web-based questionnaire in England/Ireland. Results: We analysed data on 61 patients (35 female) with a median age of 33 years (range 17-71) with average follow-up of 8 months. Maximal maintenance dose was 40mg every other week in 84% of pati

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Machado, Dialina da Conceicao Martins. "Prevalência de doença celíaca em pacientes dispépticos sem diarreia atendidos na Disciplina de Gastroenterologia e Endoscopia Digestiva do Hospital Universitário Pedro Ernesto da UERJ." Universidade do Estado do Rio de Janeiro, 2011. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=3999.

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A Doença Celíaca (DC) é uma doença autoimune que afeta o intestino delgado de indivíduos geneticamente susceptíveis após contato com o glúten. Diversos estudos têm relatado aumento da prevalência ao longo dos anos. Objetivo: Determinar a prevalência de DC em pacientes adultos sem diarreia encaminhados à Disciplina de Gastroenterologia do HUPE da UERJ para serem submetidos a Endoscopia Digestiva Alta (EDA).Comparar os resultados do histopatológico das biópsias duodenais com os resultados sorológicos, utilizando o anticorpo antitransglutaminase tecidual IgA (ATGt IgA). Métodos: Pacientes que for

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MANCUSO, CLARA. "Dietary metallic nanoparticles: a new environmental factor in the development od Celiac Disease?" Doctoral thesis, Università degli Studi di Milano-Bicocca, 2019. http://hdl.handle.net/10281/241329.

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Sebbene l'uso di nanomateriali sta crescendo, non è ancora stato capito se rappresenti un rischio per la nostra salute. Particolarmente, l'uso di nanoparticelle nell'industria alimentare è preoccupante. Infatti, differenti gruppi di ricerca hanno dimostrato che, particolarmente le nanoparticelle metalliche, possono alterare l'omeostasi intestinale. Conseguentemente potrebbero rappresentare un fattore di rischio nell'insorgenza di patologie infiammatorie intestinali, come la Celiachia. La Celiacha è una patologia autoimmune che si sviluppa in soggetti geneticamente predisposti, dopo l'ingestion

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Lisiero, Manola. "Analisi dell'epidemiologia delle patologie delle vie biliari nella Regione Veneto utilizzando le fonti correnti." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3426194.

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Digestive diseases have a relevant impact in the population for their prevalence and for health services use for various causes. In 2005 digestive diseases were the second cause of hospitalization in Italy and colon cancer was the fourth cause of death between the cancer causes of death both for men and women. The aim of the research is the study of epidemiology of gastrointestinal diseases in the Veneto Region through the analysis of current data (hospital discharge records, mortality data, drug prescriptions and "esenzioni ticket"). The study focuses on colon cancer in elderly people, gal

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Fróes, Renata de Sá Brito. "Estudo dos polimorfismos C1236T, G2677T e C3435T do gene MDR1 em pacientes portadores de doenças inflamatórias intestinais." Universidade do Estado do Rio de Janeiro, 2013. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=6380.

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Estudos recentes têm avaliado a presença de polimorfismos do gene multidroga resistente 1 (MDR1), que codifica o transportador de membrana de efluxo chamado de P-glicoproteína, seu potencial papel na suscetibilidade das doenças inflamatórias intestinais (DII) e suas possíveis correlações com aspectos clínicos das DII. Dados conflitantes podem resultar da análise genética de populações distintas. Investigamos se os polimorfismos do gene MDR1 estão associados com as DII em população do sudeste do Brasil e suas possíveis correlações com fenótipos, atividade de doença, resposta ao tratamento e efe

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PETRUZZIELLO, CARMELINA. "Small bowel capsule endoscopy in crohn’s disease diagnosis and follow up." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2010. http://hdl.handle.net/2108/209232.

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Introduzione La frequenza e la rilevanza clinica delle lesioni rilevate dalla videocapsula endoscopica (VCE) nell’intestino tenue prossimale nei pazienti con malattia di Crohn (MDC). Inoltre non è ancora definito il ruolo diagnostico della VCE nei pazienti con diagnosi non definita di MDC dopo procedure convenzionali endoscopiche, radiologiche, ultrasonografiche. Obiettivi. Studio 1. Valutare la prevalenza di lesioni prossimali rilevate dalla VCE, in pazienti con MDC dell’ileo distale. Studio 2. Valutare in uno studio prospettivo longitudinale, il ruolo diagnostico della VCE in pazienti con si

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MARABITA, FRANCESCO. "Single Nucleotide Polymorphisms and circulating microRNAs for monitoring HCV disease progression: an integrated approach." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2011. http://hdl.handle.net/10281/29993.

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Chronic Hepatitis C Virus (HCV) infection is associated with severe complications such as liver cirrhosis and hepatocellular carcinoma (HCC). For HCV infection, there is a crucial need for novel, preferably non‐invasive tests that could be used to improve the diagnosis and the management programs for patients at high risk of developing severe liver complications, such as cirrhosis and HCC. Classical biochemical markers to follow disease progression show limited potential mainly for invasiveness or little specificity and sensitivity, especially for HCC. The goal of this work was to discover us

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Chioato, Tatiana. "Studio delle capacità differenziative e della potenzialità terapeutica di cellule staminali mesenchimali umane isolate da cordone ombelicale e sangue cordonale nelle malattie epatiche acute." Doctoral thesis, Università degli studi di Padova, 2011. http://hdl.handle.net/11577/3427456.

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Liver transplantation remains the only therapeutic option for most of acute and chronic end-stage liver diseases, but its use is limited by a severe shortage of donor organs for transplantation. In this contest the use of stem cells in cell therapy can be considered a promising therapeutical approach instead of liver transplantation. In particular, mesenchymal stem cells (MSCs) can be obtained from several adult tissues and from fetal-derived tissues, such as umbilical cord (UC), umbilical cord blood (UCB) and placenta, and they can be induced to differentiate into several cell types. Never

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Mariotti, Valeria. "Molecular pathophysiology of cholangiopathies: lessons from polycystic and fibropolycystic liver disease." Doctoral thesis, Università degli studi di Padova, 2019. http://hdl.handle.net/11577/3422326.

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Cholangiocytes, the epithelial cells lining the intra- and extrahepatic biliary tree, play an essential role in regulating the production of bile and digestive functions. Cholangiocytes are also involved in the repair from liver damage and are also the target of cholangiopathies a group of acquired, congenital, or genetic complex chronic liver diseases , that represents a substantial cause of morbidity and mortality and a frequent indication for liver transplant. Treatment of cholangiopathies is unsatisfactory and these diseases are among the main unmet needs in modern hepatology. Cholangiocy

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Ferrer, Picón Elena. "Ús d’organoides humans per a l’estudi de la barrera epitelial i la resposta a productes microbians en la malaltia inflamatòria intestinal." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/666778.

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La malaltia de Crohn (MC) I la colitis ulcerosa (CU) són malalties inflamatòries intestinals cròniques (MII) causades per una desregulació de la resposta immune contra la flora comensal de l’intestí de l’hoste. El tractament farmacològic d’aquestes malalties es basa en teràpies immunosupressores convencionals o anticossos anti-TNF-α per a controlar els brots de la malaltia. En un 20-40% dels casos aquestes estratègies no resulten efectives i els pacients requereixen resecció intestinal per a controlar la malaltia. La immensa necessitat de desenvolupar noves teràpies es veu obstaculitzada per l

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Sonaglio, Etielle Pereira. "Prevalência e fatores associados à constipação intestinal em pacientes em hemodiálise." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/174722.

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Alterações gastrointestinais em pacientes com doença renal crônica são queixas comuns, sendo a constipação considerada um dos sintomas mais prevalentes. O tratamento deste sintoma é limitado nesta população, devido às modificações dietéticas impostas pela perda da função renal e métodos dialíticos, especialmente na hemodiálise. Dados locais sobre a prevalência e fatores associados à constipação são pouco conhecidos em nosso meio. Neste estudo transversal, foram incluídos 57 participantes que realizam hemodiálise há pelo menos 3 meses no Hospital Moinhos de Vento em Porto Alegre, Brasil. Um que

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García, Bosch Orlando. "Estrategias de diagnóstico y tratamiento en la enfermedad inflamatoria intestinal." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/663925.

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Las enfermedades inflamatorias intestinales (EII) son un conjunto de entidades de etiopatogenia no claramente conocida dentro de las cuales la EC y la CU son sus máximos exponentes y se asocian a una elevada morbilidad y necesidad de recursos personales, laborales y sanitarios. El arsenal terapéutico disponible para su manejo es relativamente escaso y de eficacia limitada e incluye salicilatos, corticoides, inmunomodulares y tratamientos biológicos. Determinar de forma precisa tanto la presencia de actividad, como la extensión y gravedad de la enfermedad, es esencial para definir el tratamien

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Campos, Junior Eumildo de. "Complicações cardiovasculares em pacientes com megaesôfago chagásico submetidos à cirurgia de Serra Dória." Faculdade de Medicina de São José do Rio Preto, 2011. http://bdtd.famerp.br/handle/tede/139.

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Made available in DSpace on 2016-01-26T12:51:37Z (GMT). No. of bitstreams: 1 eumildodecampos junior_tese.pdf: 1761590 bytes, checksum: 07f0e6564f9169c180cc6baf09d6de84 (MD5) Previous issue date: 2011-12-16<br>Dysphagia caused by chagasic megaesophagus compromises the clinical status and quality of life of patients. In this context, the Serra Dória s operation is a useful procedure in cases of advanced or recurrent disease. Little is known about the cardiovascular complications related to this surgery. Objective: This study aim to identify preoperative risk factors associated with cardiovascu

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Esberard, Barbara Cathalá. "Polimorfismos do gene da tiopurina metiltransferase (TPMT) em pacientes com doenças inflamatórias intestinais: avaliação da prevalência e correlação com efeitos colaterais." Universidade do Estado do Rio de Janeiro, 2013. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=6947.

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A azatioprina e a 6 mercaptopurina (6-MCP) são drogas muito utilizada no tratamento das doenças inflamatórias intestinais (DII), porém estão associadas a vários efeitos colaterais. A determinação prévia do genótipo da tiopurina metiltransferase (TPMT) pode identificar pacientes de maior risco de toxicidade a droga. Os objetivos deste estudo foram avaliar a prevalência dos polimorfismos do gene da TPMT em pacientes com DII acompanhados no Hospital Universitário Pedro Ernesto (HUPE) da UERJ, comparando com a prevalência em outras populações e correlacionar a presença desses polimorfismos com a t

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Ramos, Beatriz Peixoto. "Avaliação do estado nutricional de pacientes com doença inflamatória intestinal." Universidade do Estado do Rio de Janeiro, 2011. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=4911.

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A doença Inflamatória Intestinal (DII) é uma desordem caracterizada pela inflamação crônica do trato gastrointestinal. Os dois principais tipos de DII são a Retocolite Ulcerativa (RCU) e a Doença de Crohn (DC) e ambas cursam com importantes alterações no estado nutricional (EN). O objetivo deste estudo foi identificar as diferenças na composição corporal entre pacientes com DC, RCU e indivíduos saudáveis, além de comparar o estado nutricional dos três grupos de pacientes, ajustando para fatores que podem interferir no EN, como o uso atual de corticosteróides, a atividade física, a atividade de

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Martinato, Matteo. "Uno studio prospettico sull'infezione da Clostridium difficile nelle malattie infiammatorie croniche intestinali: fattori di rischio, tossino-tipi, sensibilità agli antibiotici, capacità di adesione e impatto sul successivo decorso della malattia." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3423091.

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Clostridium difficile is a Gram positive bacterium rarely present in normal human gut flora that under certain conditions of intestinal dysbiosis, in patients treated with broad-spectrum antibiotics, in hospitalized patients, in immunocompromised subjects and elderly, can cause disease of variable severity referred to as Clostridium Difficile Associated Diarrohea (CDAD). Although in the past Clostridium difficile has been indicated as a possible causal factor in the development of inflammatory bowel disease (also known as IBD), nowadays it is more likely to believe that the IBD may be a risk f

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Arruda, Soraia. "Estudo comparativo entre três distintas populações de candidatos a transplante hepático : avaliando a dinâmica da lista de espera em um hospital universitário." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/174699.

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INTRODUÇÃO: O transplante hepático (TxH) vem mudando o curso de doenças graves, incapacitantes e potencialmente fatais, se tornando o tratamento de escolha quando há falência do órgão. OBJETIVO: Comparar as taxas de TxH, exclusão e sobrevida entre candidatos com cirrose descompensada (CIR), situações especiais (SPE) e carcinoma hepatocelular (HCC). MÉTODOS:Foram realizados dois estudos em 358 pacientes: uma coorte retrospectiva (agosto de 2008 - julho de 2009, incluindo 189 pacientes listados) e uma prospectiva (de novembro de 2012 a maio de 2014, com um período de acompanhamento até novembro

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Câmara, Thalita de Albuquerque Véras. "IMPACTO DA CIRURGIA BARIÁTRICA NA URICEMIA E NOS INDICADORES DE RISCO CARDIOVASCULAR EM MULHERES COM SÍNDROME METABÓLICA." Universidade Federal do Maranhão, 2014. http://tedebc.ufma.br:8080/jspui/handle/tede/1196.

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Made available in DSpace on 2016-08-19T18:16:09Z (GMT). No. of bitstreams: 1 Dissertacao THALITA DE ALBUQUERQUE VERAS.pdf: 1228117 bytes, checksum: ef9a2fea64bd1f59d9de3091281a24f4 (MD5) Previous issue date: 2014-11-26<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Introduction: The association between hyperuricemia and cardiovascular risk factors, especially the metabolic syndrome and his components, has been widely documented. Despite of don t be a treatment directed to hyperuricemia, has been verified that, the bariatric surgery allowed to reach improvements on the acid

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Bassolas, Molina Helena. "Resposta T específica contra antígens de la microbiota comensal en la malaltia de Crohn i inhibició de RORγt com a estratègia terapèutica". Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/666519.

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La enfermedad de Crohn (EC) es una enfermedad Inflamatoria que puede afectar a cualquier parte del tracto digestivo. Aunque su etiología no está del todo clara, la hipótesis prevalente indica que se produce a causa de una pérdida de tolerancia contra la mlcrobiota comensal. La presencia de anticuerpos en el suero en un porcentaje importante de los pacientes con EC refuerza esta hipótesis. Esto sugiere que debe existir una respuesta T específica contra la microbiota comensal. No obstante, aunque las células T son consideradas uno de los elementos más importantes en la patogénesls de la EC, su e

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LOCATELLI, LUIGI. "Expression of aVB6 integrin by Pkhd1-defective cholangiocytes links enhanced ductal secretion of Macrophage chemokines to progressive portal fibrosis in Congenital Hepatic Fibrosis." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2013. http://hdl.handle.net/10281/41733.

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BACKGROUND AND AIMS: Congenital Hepatic Fibrosis (CHF) is caused by mutations in PKHD1, a gene encoding for fibrocystin, a protein of unknown function, expressed in cholangiocyte cilia and centromers. In CHF, biliary dysgenesis is accompanied by severe progressive portal fibrosis and portal hypertension. The mechanisms responsible for portal fibrosis in CHF are unclear. The αvβ6 integrin mediates local activation of TGFβ1 and is expressed by reactive cholangiocytes during cholestasis. To understand the mechanisms of fibrosis in CHF we studied the expression of αvβ6 integrin and its regulation

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Calado, João da Silveira Fabião de Almeida. "Celiac disease : a review." Master's thesis, 2020. http://hdl.handle.net/10451/46857.

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Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2020<br>A doença celíaca (DC) é uma doença sistémica desencadeada pela exposição ao glúten em doentes geneticamente susceptíveis. Manifesta-se como uma enteropatia auto-imune associada a auto-anticorpos e aos haplótipos HLA-DQ2 ou HLA-DQ8. A primeira referência a uma doença malabsortiva crónica que leva a um estado de desnutrição remonta a Aretaeus, na Cappadocia, no seculo III d.C, contudo, a primeira descrição clínica moderna da DC data de 1888, no artigo de Samuel Gee, “On the coeliac a

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Martins, Andres Alexander Vasquez. "Manifestações mais frequentes na cavidade oral causadas por doenças inflamatórias intestinais em pacientes que frequentam a consulta de gastroenterologia do Hospital Geral de Viseu." Master's thesis, 2018. http://hdl.handle.net/10400.14/26148.

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Introdução: Actualmente, um dos problemas que em maior grau afectam e dificultam o perfeito funcionamento do corpo humano, num elevado número de indivíduos, dizem respeito às diversas doenças que afectam o aparelho digestivo. A doença de Crohn e a colite ulcerosa são as que apresentan maiores manifestações extra-intestinais com atingimento da cavidade oral e, como consequência diminuindo a qualidade de vida dos individuos que padecem desta doença. Objetivo: O objetivo do presente estudo foi descrever as manifestações e sintomatologia oral presentes na doença inflamatória intestinal. Materiai

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Fernandes, Inês Cristina Ferreira. "Non‐celiac gluten sensitivity : a real disease?" Master's thesis, 2016. http://hdl.handle.net/10451/26731.

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Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2016<br>The past years have seen an increase in the use of a gluten-‐free diet (GFD) outside a diagnosis of coeliac disease (CD) or wheat allergy (WA). This trend has led to the identification of a new clinical entity termed non-‐celiac gluten sensitivity (NCGS), which has clinical features that overlap with those two previously mentioned. The onset of symptoms in patients with NCGS can occur within hours or days of gluten ingestion and the prevalence of NCGS is estimated to round 6%. Th

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Adams, Mariana Guimarães. "Inflammatory bowel disease in the elderly : a review of the literature." Master's thesis, 2017. http://hdl.handle.net/10451/32605.

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Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2017<br>The aging of the population makes the problematic of inflammatory bowel disease in the elderly of increasing concern. The complexity of this age group, with its comorbidities, changing physiology and functional status, risk of polypharmacy and adverse effects, presents the caring physician with unique challenges in the management of this chronic condition. Current therapeutic algorithms may not be applicable in the elderly population and require modifications that account for age.

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TROVATO, CHIARA MARIA. "HLA-DQ and celiac disease: a novel risk gradient for predisposed subjects." Doctoral thesis, 2021. http://hdl.handle.net/11573/1553689.

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BACKGROUND. Celiac disease (CeD) is an immune-mediated systemic disorder elicited by gliadin, a prolamine found in wheat and related proteins, occurring in genetically predisposed individuals, carrying HLA-DQ2 and/or DQ8. Several heterodimers have been associated with CeD: the HLA-DQ2.5, occurring in approximately 90% of CeD patients, is encoded by the DQB1*02 and DQA1*05 alleles both in cis and in trans; the HLA-DQ2.2 heterodimer, encoded by the DQB1*02 and DQA1*02 allele; and the HLA- DQ8 heterodimer, encoded by the DQB1*03:02 and DQA1*03 alleles. AIMS. We aimed: 1) To characterize HLA polym

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FIASCHINI, NOEMI. "The role of intestinal inflammation on the gut-liver axis." Doctoral thesis, 2021. http://hdl.handle.net/11573/1495678.

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The gut and the liver are anatomically related by portal circulation, and their functional unit realizes the gut-liver axis (GLA) with the integrity of intestinal barrier crucial for the maintenance of liver homeostasis. The GLA connects the liver with the intestine via bile acid metabolism. Bile acids (BAs) are amphipathic steroid acids, synthesized from cholesterol in the liver, that regulate lipid, glucose and energy metabolism. Moreover, a specific role of BAs as immunomodulators is emerging. The regulatory functions of BAs are predominantly mediated by the bile receptors, such as the nu

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SAGNOTTA, ANDREA. "Gastrectomia e strategie multimodali nel trattamento del cancro gastrico in stadio IV: risultati oncologici di 16596 pazienti." Doctoral thesis, 2019. http://hdl.handle.net/11573/1263695.

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Objectives This population-based study aimed to investigate the survival benefit of treatment strategies in metastatic gastric cancer (GC) patients, focusing on role and timing of gastrectomy. Methods We included eligible stage IV GC patients in the Surveillance, Epidemiology and End Results (SEER) database from 2004 to 2015. Overall (OS) and Cancer Specific Survival (CSS) rates were calculated by Kaplan–Meier analysis and log-rank test. Multivariate Cox analysis was performed to analyze the effect of gastrectomy performed alone, before (Primary gastrectomy, PG) or after (Secondary Gastrec

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Silveira, Pedro Filipe Dores Mateus da. "Síndrome dilatação-torção gástrica: revisão bibliográfica e estudo de 32 casos clínicos." Master's thesis, 2018. http://hdl.handle.net/10437/9414.

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Orientação: Daniel Murta ; orientação externa: Sofia Domingues<br>A síndrome dilatação-torção gástrica é uma condição aguda, médica e cirúrgica, comum em canídeos, que se caracteriza por uma rápida acumulação de ar com distensão e mau posicionamento do estômago, levando ao choque do animal e pondo em risco a sua vida. Ainda não foi identificada uma causa única para o seu desenvolvimento, mas foram propostos diversos fatores de risco que estão provados terem uma relação de causalidade com a síndrome. Este estudo teve como objetivo a caracterização de casos com síndrome dilatação-torção gástric

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