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Dissertations / Theses on the topic 'Gene-For-Gene interaction'

Author: Grafiati
Published: 8 June 2024
Last updated: 31 July 2025

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1

Assareh, Amin. "OPTIMIZING DECISION TREE ENSEMBLES FOR GENE-GENE INTERACTION DETECTION." Kent State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=kent1353971575.

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2

Bendahmane, Abdelhafid. "Analysis of a gene-for-gene interaction associated with Rx-mediated resistance to potato virus X." Thesis, University of East Anglia, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389350.

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3

Aleknonytė-Resch, Milda [Verfasser], Astrid [Akademischer Betreuer] Dempfle, and Hinrich [Gutachter] Schulenburg. "The Validity and Statistical Power of the Case-Only Study Design for Interaction Analysis : Gene-Gene Interaction and the Role of Genotype Imputation in Gene-Environment Interaction / Milda Aleknonytė-Resch ; Gutachter: Hinrich Schulenburg ; Betreuer: Astrid Dempfle." Kiel : Universitätsbibliothek Kiel, 2021. http://d-nb.info/1229916962/34.

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4

Elisson, Hanna. "Uncertainty in Genetic Mapping and Gene Interaction for Diabetes in Rats." Thesis, Uppsala University, Department of Mathematics, 2000. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-122559.

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5

MacGowan, Alice Laura. "Embryonic retinoid deficiency and congenital malformation : evidence for gene-environment interaction." Thesis, University of Sheffield, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398657.

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6

Thi, Cam Thach Doan. "A GRAPHICAL USER INTERFACE FOR LARGE-SCALE GENE EXPRESSION ANALYSIS." Thesis, Högskolan i Borås, Institutionen Handels- och IT-högskolan, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-20870.

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Recently, the whole-genome expression analysis – which is analyzing most or all of the genes in biological systems, and is a rich and powerful way to discover gene pathway - has become increasingly affordable because of the increasing amount of microarray data available in public databases. Additionally, due to the enormously available information content in these repositories, researchers have to spend large amount of time to decide on the right information to proceed. There should be an application to assist biological researchers reducing the time in finding good data sets to analyze. In th
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7

Korkmaz, Gulberal Kircicegi Yoksul. "Mining Microarray Data For Biologically Important Gene Sets." Phd thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12614266/index.pdf.

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Microarray technology enables researchers to measure the expression levels of thousands of genes simultaneously to understand relationships between genes, extract pathways, and in general understand a diverse amount of biological processes such as diseases and cell cycles. While microarrays provide the great opportunity of revealing information about biological processes, it is a challenging task to mine the huge amount of information contained in the microarray datasets. Generally, since an accurate model for the data is missing, first a clustering algorithm is applied and then the resulting
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8

Piqueras, Matias. "HERITABILITY FOR SOCIAL TRUST ACROSS SOCIOECONOMIC STATUS: : Is There a Gene-Environment Interaction?" Thesis, Uppsala universitet, Statsvetenskapliga institutionen, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-394876.

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In political science literature, the development of social trust is often explained in terms of the influence of different environmental factors, socioeconomic status (SES) being one of the most important. Yet, even though there is empirical support of a genetic component in the expression of social trust, less is known about its interaction with environmental factors. The present study aims to explore heritability of social trust across socioeconomic status using a twin-design that tests potential gene-environment (GxE) interactions. Moreover, the study explicitly tests the hypothesis that di
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9

Cai, Yu. "Molecular Characterization of the mop2, a Gene Required for Epigenetic Silencing." Diss., The University of Arizona, 2006. http://hdl.handle.net/10150/195361.

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The mop2 gene is required for epigenetic silencing; it was originally defined as a mutation, Mop2-1, which when dominant prevented paramutation at b1. Paramutation is an allele communication that causes a mitotically and meiotically heritable change in gene expression. Mop2-1 was subsequently shown to be involved in maintaining the silenced paramutant state and to prevent dsRNA-mediated transcriptional gene silencing (activities revealed only when the mutation is homozygous). Understanding the product encoded by mop2 will help dissect the underlying mechanisms involved in paramutation and
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10

Mietzsch, Mario [Verfasser]. "Adeno-Associated Virus Vectors for Gene Therapy : From Scalable Production Systems via Serotype-Specific Glycan Interaction Patterns to Gene Transfer Applications / Mario Mietzsch." Berlin : Freie Universität Berlin, 2014. http://d-nb.info/1055942203/34.

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11

Sadie, Hanel. "Interaction of SF-1 and Nur77 proteins from a gonadotrope cell line with the promoter of the GnRH receptor gene : implications for gene regulation." Thesis, Stellenbosch : Stellenbosch University, 2001. http://hdl.handle.net/10019.1/52307.

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Thesis (MSc)--Stellenbosch University, 2001.<br>ENGLISH ABSTRACT: The regulation of gonadotropin releasing hormone (GnRH) receptor numbers in the pituitary is a crucial control point in reproduction. Pituitary sensitivity to GnRH can be directly correlated with GnRH receptor levels, which can be regulated at transcriptional and post-transcriptional level. The proximal promoter of the mouse GnRH receptor gene contains two cis elements bearing the consensus sequence for a Steroidogenic Factor-l (SF -1) binding site. The distal site has previously been shown to be involved in basal and tiss
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12

Dafas, Panagiotis A. "Frequency rule mining for effective protein-protein interaction inference from gene expression and protein structures." Thesis, City University London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492255.

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The experimental measurement of gene expression levels has produced preliminary results on the regulation, pathways and networks of genes in cells. Furthermore, the number of available three-dimensional folded structures of proteins increases on a daily basis. The ultimate aim of both genomics and proteomics froni the perspective of bioinformatics, is to map out all the circuits of energy and information processing in life by terms of molecular interactions in a system~tic way with minimal human intervention. In this thesis we propose a new rule mining framework for ill silico inference of pro
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13

Singh, Lovepreet. "Characterization of new sources and superior gene combinations for durable resistance to leaf rust in barley." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/24783.

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One hundred fourteen barley lines were screened with diverse pathotypes (pts) of Puccinia hordei in the greenhouse (GH) and field to characterize resistance. The GH tests revealed the presence of all stage resistance (ASR) genes Rph1, Rph2, Rph3, Rph12 and Rph19 either individually or in combination, whereas field tests revealed the presence of adult plant resistance (APR) in 74.5% of the test lines. Molecular markers linked to known genes demonstrated presence of Rph15 (3 lines), Rph20 (5 lines), Rph23 (8 lines), Rph24 (19 lines), and the combinations Rph20+Rph23 or Rph20+Rph24 or Rph23+Rph24
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14

Ackerman-Alexeeff, Stacey Elizabeth. "Measurement error in environmental exposures: Statistical implications for spatial air pollution models and gene environment interaction tests." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11077.

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Measurement error is an important issue in studies of environmental epidemiology. We considered the effects of measurement error in environmental covariates in several important settings affecting current public health research. Throughout this dissertation, we investigate the impacts of measurement error and consider statistical methodology to fix that error.
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15

Pelliccia, M. "STRATEGIES FOR ENHANCING VIRAL GENE TRANSFER AND THE THERMOSTABILITY OF VIRAL VECTORS IN VACCINE APPLICATIONS." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/265518.

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At the most basic level viruses are biological nano-containers constituted by genetic material enclosed in a protein shell, capsid. A peculiar feature of viruses, both bacterial and some eukaryotic viruses, lies in the high packaging density of the genome in order to fit itself in the small capsid and hence the high internal osmotic pressure. Virus is a relatively stable particle equipped with fascinating mechanical properties of the capsid that are crucial for the virus lifecycle. Viruses have only one purpose: infect a host cell for reproducing themselves in order to generate new viral proge
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16

Pizzato, Massimo. "Retroviral vectors for gene therapy : characterisation of vector particle-cell interaction and development of novel packaging cell lines." Thesis, Institute of Cancer Research (University Of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313365.

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17

Rubin, Joel Edward. "Locus control region activity by 5'HS3 requires a functional interaction with ß-globin gene regulatory elements, identification of effective ß/[gamma]-globin minigenes for gene therapy of the ß-chain hemoglobinopathies." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0025/MQ50431.pdf.

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18

Armando, Marco. "Psychotic like experiences and 22q11 microdeletion syndrome : two possible models for the investigation of gene-enviroment interaction in psychotic onset." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/3940/.

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Psychotic disorders can be defined as disorders of adaptation to social context. Although heritability is often emphasized, onset must be considered as the end-point of a pathway which involves: 1) genetic heritability; 2) environmental factors; 3) psychopathological factors. Therefore, the current challenge consists in combining different scientific fields aiming at a deeper comprehension of psychotic disorders. Taking off these considerations, this thesis will present research conducted in Rome (Children Hospital Bambino Gesù) and in Birmingham (Department of Psychology, University of Birmin
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19

Mota, Lúcio Flávio Macêdo. "Estimation of genotype-environment interaction using genomic reaction norm and analysis of gene network for reproductive traits in Nellore cattle /." Jaboticabal, 2019. http://hdl.handle.net/11449/181612.

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Orientador: Lucia Galvão de Albuquerque<br>Banca: Mário Luiz Santana Júnior<br>Banca: Fernando Sebastian Baldi Rey<br>Banca: Ana Fabrícia Braga Magalhães<br>Banca: Roberto Carvalheiro<br>Abstract: Genotype-environment (GxE) interactions could be an important source of variation in reproductive traits with a striking effect on the onset of animal puberty. Thus, the objectives of the present study were: i) to assess the GxE interaction in Nellore sexual precocity indicator traits under different environmental conditions (EC) and ii) to identify, genomic regions and biological pathways associated
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20

Burbanks, Samuel IV. "Gene-Culture Interaction and its Effect on Cognitive Flexibility Among People of African and European Descent: Providing a Rational for Culturally Centered Pedagogy." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1511881054307915.

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21

Du, Shenxiu [Verfasser]. "Functional Characterizations of the Reciprocal Interaction of the Circadian Clock gene Time for coffee (TIC) with Stress and Energy in Arabidopsis / Shenxiu Du." Bonn : Universitäts- und Landesbibliothek Bonn, 2017. http://d-nb.info/1130704610/34.

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22

Martin, Isabelle. "Étude du déterminisme moléculaire des Interactions compatibles et incompatibles Vitis vinifera-Nepovirus-Nicotiana occidentalis (InViNNo)." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAJ102.

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Le Grapevine fanleaf virus (genre Nepovirus) est l'agent principal du court-noué de la vigne. Il induit des symptômes très variables. Ce travail présente une étude mécanistique de la symptomatologie du GFLV sur un hôte herbacé et sur l'hôte d’intérêt agronomique. Par détection de marqueurs biochimiques et moléculaires j'ai montré que le GFLV-F13 induit une réponse hypersensible (HR) sur N. occidentalis et une restriction partielle du virus. J'ai identifié puis cartographié le déterminant viral de cette HR en utilisant des réassortants, des recombinants et des variants naturels du virus. Sur vi
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23

Louet, Clémentine. "Analyses évolutive et moléculaire des déterminants génétiques impliqués dans l’interaction entre l’agent de la rouille du peuplier et son hôte." Electronic Thesis or Diss., Université de Lorraine, 2021. http://www.theses.fr/2021LORR0264.

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Melampsora larici-populina (Basidiomycète, Pucciniales) est un champignon biotrophe obligatoire qui infecte successivement deux hôtes, le peuplier et le mélèze, et qui produit cinq types de spores au cours de son cycle de vie. Ce dernier est l’agent causal de la rouille du peuplier, la principale contrainte sanitaire dans les peupleraies européennes. Un des objectifs de l’UMR Interactions Arbres/Microorganismes est de caractériser les déterminants moléculaires impliqués dans l’interaction entre le peuplier et M. larici-populina et d’étudier leur évolution. Cette thèse, reposant sur la mobilisa
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24

Tellier, Aurélien. "A theory of polymorphism in gene-for-gene interactions." Thesis, University of East Anglia, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439932.

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25

Schmid, Ramona [Verfasser], and Roland [Akademischer Betreuer] Eils. "Analyzing Compounds’ Mode of Action - A Use Case for New Approaches Utilizing Protein Interaction Networks and Prior Knowledge to Complement State-of-the-Art Gene Expression Analyses / Ramona Schmid ; Betreuer: Roland Eils." Heidelberg : Universitätsbibliothek Heidelberg, 2012. http://d-nb.info/1179786343/34.

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26

Sanders, Chelsea L. "Gene-Environment Interaction: Brain-Derived Neurotrophic Factor (BDNF) as a Moderating Factor for the Effects of Exercise and Diet on Cognitive and Mental Health: The Cache County Study on Memory in Aging." DigitalCommons@USU, 2018. https://digitalcommons.usu.edu/etd/7163.

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The Cache County Study on Memory in Aging, funded by the National Institute on Aging, studied longitudinal changes in memory and aging over 12 years’ follow-up in a population-based sample of 5,092 older adults in semirural Cache County, UT. Among the extensive interview procedures, researchers collected information regarding the participants’ demographics, health, genetic factors, diet, physical activity, and cognitive abilities. This study has allowed researchers to investigate how genetic and modifiable lifestyle factors interact to predict health, cognitive function, and psychological well
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27

Deodhar, Sushamna Shriniwas. "Using Grammatical Evolution Decision Trees for Detecting Gene-Gene Interactions in Genetic Epidemiology." NCSU, 2009. http://www.lib.ncsu.edu/theses/available/etd-10302009-181439/.

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A major goal of human genetics is the discovery and validation of genetic polymorphisms that predict common, complex diseases. It is hypothesized that complex diseases are due to a myriad of factors including environmental exposures and complex genetic models. This etiological complexity, coupled with rapid advances in genotyping technology present enormous theoretical and practical concerns for statistical and computational analysis. Specifically, the challenge presented by epistasis, or gene-gene interactions, has sparked the development of a multitude of statistical techniques over the year
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28

Vardarajan, Badri N. "Identification of gene-gene interactions for Alzheimer's disease using co-operative game theory." Thesis, Boston University, 2013. https://hdl.handle.net/2144/12868.

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Thesis (Ph.D.)--Boston University<br>The multifactorial nature of Alzheimer's Disease suggests that complex gene-gene interactions are present in AD pathways. Contemporary approaches to detect such interactions in genome-wide data are mathematically and computationally challenging. We investigated gene-gene interactions for AD using a novel algorithm based on cooperative game theory in 15 genome-wide association study (GWAS) datasets comprising of a total of 11,840 AD cases and 10,931 cognitively normal elderly controls from the Alzheimer Disease Genetics Consortium (ADGC). We adapted this app
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29

Schmitt, Dominique [Verfasser], Michael [Gutachter] Sendtner, and Erich [Gutachter] Buchner. "Initial characterization of mouse Syap1 in the nervous system: Search for interaction partners, effects of gene knockdown and knockout, and tissue distribution with focus on the adult brain / Dominique Schmitt ; Gutachter: Michael Sendtner, Erich Buchner." Würzburg : Universität Würzburg, 2017. http://d-nb.info/1130588033/34.

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30

Dang, Hoang Viet. "Identification of gene-gene and gene-environment interactions for flowering time and grain yield using a multi-parental mapping population in barley." Thesis, Dang, Hoang Viet (2021) Identification of gene-gene and gene-environment interactions for flowering time and grain yield using a multi-parental mapping population in barley. PhD thesis, Murdoch University, 2021. https://researchrepository.murdoch.edu.au/id/eprint/62713/.

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Grain yield improvement is considered the key target for many cereal breeding programs. In barley, grain yield is closely associated with flowering time, which provides crops with the opportunity to avoid stress and to best utilise available environmental resources. In this study, major genes associated with flowering time were identified using a multiparent advanced generation intercross (MAGIC) population constructed from four commercial barley cultivars (Compass, GrangeR, La Trobe and Lockyer). Gene-specific markers were developed for fast-screening of phenology genes in 1,919 MAGIC recombi
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31

Win, Joe. "Molecular Quest for Avirulence Factors in Venturia inaequalis." Thesis, University of Auckland, 2004. http://hdl.handle.net/2292/397.

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The molecular basis for the gene-for-gene relationship of Vm-resistance in apple to Venturia inaequalis was investigated. Incompatible reactions involved a hypersensitive response (HR), which was accompanied by the accumulation of dark brown pigments and autofluorescent materials in epidermal and mesophyll cells at the site of invasion. Cell-free culture filtrates of the avirulent isolate elicited an HR in the Vm host (h5) leaves, but not in the susceptible host (h1). The elicitor activity was resistant to boiling but was abolished by proteinase K digestion. Elicitation of HR was used to monit
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32

Alavi, Hajar Karimi. "Development of mechanistic mathematical models for gene-mediated drug-drug interactions." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/development-of-mechanistic-mathematical-models-for-genemediated-drugdrug-interactions(b38da88a-bb2a-4667-9809-21a09c8feeeb).html.

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The glucocorticoid receptor (GR) is a member of the nuclear hormone receptors family and has been shown to exert significant effects on the induction of cytochrome P450 (CYP) enzymes responsible for the metabolism of many xenobiotics. CYP3A4/5 and CYP2C9 are important CYP enzymes which metabolise more that 60% of drugs. Induction or inhibition of the enzymatic activity and the levels of these enzymes can have significant effects on drug metabolism. Understanding the role of GR and other nuclear receptors, pregnane X receptor (PXR) and the constitutive androstane receptor (CAR), in the mechanis
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33

Dameh, Mustafa, and n/a. "Insights into gene interactions using computational methods for literature and sequence resources." University of Otago. Department of Anatomy & Structural Biology, 2008. http://adt.otago.ac.nz./public/adt-NZDU20090109.095349.

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At the beginning of this century many sequencing projects were finalised. As a result, overwhelming amount of literature and sequence data have been available to biologist via online bioinformatics databases. This biological data lead to better understanding of many organisms and have helped identify genes. However, there is still much to learn about the functions and interactions of genes. This thesis is concerned with predicting gene interactions using two main online resources: biomedical literature and sequence data. The biomedical literature is used to explore and refine a text mining m
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34

Mickler, Frauke Martina. "Live-cell imaging elucidates cellular interactions of gene nanocarriers for cancer therapy." Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-165829.

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35

Golding, Pauline Lindsay. "Development of a statistical method for the identification of gene-environment interactions." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/6520.

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In order to understand common, complex disease it is necessary to consider not just genetic risks and environmental risks, but also the interplay between them. This thesis aims to develop methodology for the detection of gene-environment interactions specifically; both by looking at the strengths and weaknesses of traditional approaches and through the development and testing of a novel statistical method. Developments in genotyping technology enable researchers to collect large volumes of polymorphisms in human genes, yet very few statistical methods are able to handle the volume, variation a
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36

Tamburino, Alex M. "A Gene-Centered Method For Mapping 3’UTR-RBP Interactions: A Dissertation." eScholarship@UMMS, 2015. https://escholarship.umassmed.edu/gsbs_diss/793.

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Interactions between 3´ untranslated regions (UTRs) and RNA-binding proteins (RBPs) play critical roles in post-transcriptional gene regulation. Metazoan genomes encode hundreds of RBPs and thousands of 3’ UTRs have been experimentally identified, yet the spectrum of interactions between 3´UTRs and RBPs remains largely unknown. Several methods are available to map these interactions, including protein-centered methods such as RBP immunoprecipitation (RIP) and cross-link immunoprecipitation (CLIP), yeast three-hybrid assays and RNAcompete. However, there is a paucity of RNA-centered approaches
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Tamburino, Alex M. "A Gene-Centered Method For Mapping 3’UTR-RBP Interactions: A Dissertation." eScholarship@UMMS, 2008. http://escholarship.umassmed.edu/gsbs_diss/793.

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Interactions between 3´ untranslated regions (UTRs) and RNA-binding proteins (RBPs) play critical roles in post-transcriptional gene regulation. Metazoan genomes encode hundreds of RBPs and thousands of 3’ UTRs have been experimentally identified, yet the spectrum of interactions between 3´UTRs and RBPs remains largely unknown. Several methods are available to map these interactions, including protein-centered methods such as RBP immunoprecipitation (RIP) and cross-link immunoprecipitation (CLIP), yeast three-hybrid assays and RNAcompete. However, there is a paucity of RNA-centered approaches
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38

van, der Aa Eveline Maria. "Synthesis and Characterization of Nucleobase-Containing Polyelectrolytes for Gene Delivery." Thesis, Virginia Tech, 2010. http://hdl.handle.net/10919/33008.

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Wide literature precedence exists for polymers containing electrostatic interactions and polymers containing hydrogen bonding motifs, however the combination of electrostatic and hydrogen bonding interactions is not widely investigated in current literature. Polyelectrolytes containing hydrogen bonding groups are expected to exhibit properties of both classes of supramolecular interactions. A series of adenine- and thyminecontaining PDMAEMA and tert-butyl acrylate copolymers were synthesized to investigate the effect of incorporating hydrogen bonding groups into a polyelectrolyte. Incor
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39

Taha, May. "Probing sequence-level instructions for gene expression." Thesis, Montpellier, 2018. http://www.theses.fr/2018MONTT096/document.

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La régulation des gènes est fortement contrôlée afin d’assurer une large variété de types cellulaires ayant des fonctions spécifiques. Ces contrôles prennent place à différents niveaux et sont associés à différentes régions génomiques régulatrices. Il est donc essentiel de comprendre les mécanismes à la base des régulations géniques dans les différents types cellulaires, dans le but d’identifier les régulateurs clés. Plusieurs études tentent de mieux comprendre les mécanismes de régulation en modulant l’expression des gènes par des approches épigénétiques. Cependant, ces approches sont basées
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Altarawy, Doaa Abdelsalam Ahmed Mohamed. "DeTangle: A Framework for Interactive Prediction and Visualization of Gene Regulatory Networks." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/85504.

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With the abundance of biological data, computational prediction of gene regulatory networks (GRNs) from gene expression data has become more feasible. Although incorporating other prior knowledge (PK), along with gene expression, greatly improves prediction accuracy, the accuracy remains low. PK in GRN inference can be categorized into noisy and curated. Several algorithms were proposed to incorporate noisy PK, but none address curated PK. Another challenge is that much of the PK is not stored in databases or not in a unified structured format to be accessible by inference algorithms. Moreover
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41

Rauschhuber, Christina. "Analysis of Adenovirus-Host Interactions to Improve Recombinant Adenoviral Vectors for Gene Therapy." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-128560.

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42

Ucar, Duygu. "Constructing and Analyzing Biological Interaction Networks for Knowledge Discovery." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1250656196.

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43

Harpe, Anke von. "Polyethylenimine derivatives for gene transfer : Polymer synthesis, coupling of ligands and interactions with DNA /." Marburg : Görich & Weiershäuser, 2000. http://www.gbv.de/dms/bs/toc/319704181.pdf.

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44

Thorén, Per. "Membrane interactions of arginine-rich peptides for the intracellular delivery of gene-targeted drugs /." Göteborg : Chalmers Univ. of Technology, 2003. http://www.gbv.de/dms/bs/toc/37405925X.pdf.

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45

Broc, Camilo. "Variable selection for data aggregated from different sources with group of variable structure." Thesis, Pau, 2019. http://www.theses.fr/2019PAUU3048.

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Durant les dernières décennies, la quantité de données disponibles en génétique a consi-dérablement augmenté. D’une part, une amélioration des technologies de séquençage demolécules a permis de réduire fortement le coût d’extraction du génome humain. D’autrepart, des consortiums internationaux d’institutions ont permis la mise en commun de lacollecte de données sur de larges populations. Cette quantité de données nous permetd’espérer mieux comprendre les mécanismes régissant le fonctionnement de nos cellules.Dans ce contexte, l’épidémiologie génétique est un domaine cherchant à déterminer lare
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Gerson, Rosalind J. "The Interaction Between Sir3 and Sir4 is Dispensable for Silent Chromatin Spreading in Budding Yeast." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32232.

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In Saccharomyces cerevisiae, telomeric and HM silencing requires the histone deacetylase Sir2 and the chromatin binding proteins Sir3 and Sir4, which interact to form the SIR complex. Silent chromatin formation begins with a nucleation step, followed by spreading of Sir proteins along chromatin. Overexpression of Sir3 extends silent chromatin domains, however the role of Sir protein interactions within silent chromatin extensions remains unknown. Here, we generated the Sir3 mutant, Sir3-4A, which cannot interact with Sir4 but is capable of forming silent chromatin extensions when overexpressed
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47

Skaggs, Hollie Suzanne. "IMPLICATIONS FOR THE INTERACTION BETWEEN THE HEAT SHOCK TRANSCRIPTION FACTORS AND THE TRANSLOCATED PROMOTER REGION PROTEIN." UKnowledge, 2007. http://uknowledge.uky.edu/gradschool_diss/503.

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The heat-shock response is one of the many complex physiological systems that organisms have developed in order to protect their cells against stress. This response is initiated by the binding of heat shock factor 1 (HSF1) to the promoters of genes containing heat-shock elements (HSEs,) which results in the expression of several proteins, among them the proteo-protective inducible heat-shock protein (hsp70i). Due to HSF1s critical role in this process, an active area of research is trying to understand of how HSF1 executes its function. Considering the rapidity with which the field of cell bio
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48

Huttner, Nadja. "Adeno-associated virus type 2 as vector for human gene therapy: Characterization of virus-host interactions." Diss., lmu, 2003. http://nbn-resolving.de/urn:nbn:de:bvb:19-14207.

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49

duVerle, David Alexander. "Building a Machine-Learning Framework for Protein Interactions: Calpain Cleavage Prediction and Gene Regulatory Network Inference." 京都大学 (Kyoto University), 2012. http://hdl.handle.net/2433/157921.

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50

Bankers, Laura. "Parasites, ploidy, and sex: implications for gene expression and adaptive molecular evolution in Potamopyrgus antipodarum." Diss., University of Iowa, 2017. https://ir.uiowa.edu/etd/5709.

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The trajectory of evolutionary adaptation can be influenced both by the interactions of organisms with their environments as well as by the biological characteristics of the organisms themselves. My dissertation research uses the New Zealand freshwater snail Potamopyrgus antipodarum to 1) gain important insight into how coevolutionary interactions between hosts and parasites influence patterns of gene expression and genetic differentiation of hosts and, 2) evaluate how reproductive mode, and ploidy level affect patterns of adaptive molecular evolution. Coevolutionary interactions between hosts
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