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1

Pietruska, Jamie L. "Gilded Age Redux." Reviews in American History 45, no. 3 (2017): 457–63. http://dx.doi.org/10.1353/rah.2017.0066.

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Robert M. Calhoon. "Gilded Age Statecraft." Reviews in American History 38, no. 1 (2010): 99–103. http://dx.doi.org/10.1353/rah.0.0172.

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Wood Presber, Lucia. "Les Gillies, chansons traditionnelles des tsiganes britanniques ou « can you dukker a rai ? »." Etudes Tsiganes 36, no. 4 (2008): 60. http://dx.doi.org/10.3917/tsig.036.0060.

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4

Morgan, H. Wayne (Howard Wayne). "Art-Culture in the Gilded Age." Reviews in American History 25, no. 4 (1997): 589–93. http://dx.doi.org/10.1353/rah.1997.0141.

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Bystrom, Kerry. "Healing South African Wounds/ Guérir les blessures de l'Afrique du Sud, ed. Gilles Teulié and Mélanie Joseph-Vilan." Research in African Literatures 42, no. 1 (March 2011): 195–96. http://dx.doi.org/10.2979/ral.2011.42.1.195.

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Jardim, Alex Fabiano Correia. "Como sair da ilha da minha consciência: Gilles Deleuze e uma crítica à subjetividade transcendental em Edmund Husserl." PHENOMENOLOGICAL STUDIES - Revista da Abordagem Gestáltica 16, no. 1 (2010): 109–10. http://dx.doi.org/10.18065/rag.2010v16n1.14.

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Christol, Michel, Émilie Compan, Réjane Roure, Maxime Scrinzi, and Christophe Vaschalde. "Nouvelles données sur l’occupation romaine du comptoir protohistorique d’Espeyran (Saint-Gilles-du-Gard) : découverte d’une inscription de la gens Calvia." Revue archéologique de Narbonnaise 44, no. 1 (2011): 145–61. http://dx.doi.org/10.3406/ran.2011.1825.

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Dujardin, Laurent, Jean-François Legembre, Dominique Lenrouilly, and Jean-Yves Marin. "Les carrières médiévales du quartier Saint-Gilles de Caen. Etude archéologique de deux exploitations de pierre à bâtir en souterrain." Revue archéologique de l'ouest 8, no. 1 (1991): 169–81. http://dx.doi.org/10.3406/rao.1991.1143.

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Marcus, Robert D. "Lost and Found Department: A Gilded Age President." Reviews in American History 23, no. 4 (1995): 618–22. http://dx.doi.org/10.1353/rah.1997.0107.

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10

Hughes, Kate. "Foreword." Sibbaldia: the International Journal of Botanic Garden Horticulture, no. 19 (March 18, 2021): 1–4. http://dx.doi.org/10.24823/sibbaldia.2020.339.

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An introduction to volume 19. With thanks to reviewers of papers in this volume: Crinan Alexander, Leonie Alexander, Peter Brownless, Matthew Denton-Giles, Andrew Ensoll, Edeline Gagnon, Martin Gardner, Rebecca Hilgenhof, Fiona Inches, Ross Kerby, David Knott, David Rae, Helen Thompson and anonymous reviewers. Typeset by Fakenham Prepress Solutions, Fakenham, Norfolk NR21 8NL.
11

Cloirec, Gaétan Le. "L’établissement gallo-romain de la chapelle Saint-Gilles à Gouarec (Côtes-d’Armor) : un modèle d’habitat rural inédit dans l’Ouest de la Gaule." Revue archéologique de l'Ouest, no. 28 (December 31, 2011): 183–218. http://dx.doi.org/10.4000/rao.1540.

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12

Yebra Pertusa, José María. "Retro-Victorianism and the simulacrum of art in Will Self's Dorian: An imitation." Revista Alicantina de Estudios Ingleses, no. 23 (December 15, 2010): 231. http://dx.doi.org/10.14198/raei.2010.23.13.

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This essay aims at exploring Will Self’s novel Dorian: An Imitation (2002) as a postmodernist revision of Oscar Wilde’s celebrated The Picture of Dorian Gray (1891). Exceptional for ones, immoral and shameful for others, Dorian: An Imitation fosters an intertextual relation with the late-Victorian hypotext whereby both texts are transformed out of a refractory process. Like its predecessor, Self’s novel is primarily interested in aesthetic issues. In this light, my main concern consists in analysing the artistic discourses that Dorian: An Imitation reflects and deflects in the era of simulation. Likewise, I examine how the novel delves into the problematic relationship between “reality” and “fiction”, original and simulacra. At the turn of the millennium, when virtual reality/ies are generated by computers, literature has a challenge which, in my view, Self’s novel deals with. Thus, from the theories of simulation proposed by Jean Baudrillard and, to a lesser extent, Gilles Deleuze, my essay confronts Dorian as a valuable text: it adapts the discourse of new technologies to literary language; it goes into the postmodernist ontological crisis; and, finally, it opens up the debate of aesthetic interaction between the canon and new literatures.
13

Hartmann Virnich, Andreas. "Le rôle des matériaux antiques en réemploi dans la sculpture monumentale antiquisante en Provence romane : l'exemple d'Arles et de Saint-Gilles-du-Gard." Revue archéologique de Narbonnaise 33, no. 1 (2000): 288–92. http://dx.doi.org/10.3406/ran.2000.1567.

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14

Thomas, Samuel J. "Mugwump Cartoonists, the Papacy, and Tammany Hall in America’s Gilded Age." Religion and American Culture: A Journal of Interpretation 14, no. 2 (2004): 213–50. http://dx.doi.org/10.1525/rac.2004.14.2.213.

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AbstractIn the Gilded Age of extreme partisan politics, Puck magazine, the nation's premier journal of graphic humor and political satire, played an important role as a non-partisan crusader for good government and the triumph of American constitutional ideals. Its prime targets, however, were not just corrupt machine politicians. The magazine included as well what it, like the letterpress, condemned as the nefarious political agenda of the Catholic church, especially its new pope, Leo XIII. Indeed, New York's infamous Tammany Hall, committed to spoils and patronage as the means of dominating the body politic, was all the more dangerous to Puck because, beginning in the 1870s, Irish Catholics dominated it. The hall's Irish Catholic base enabled the magazine to rationalize more completely its conviction that the Catholic church, ruled by a foreign potentate dressed in the irrational garb of infallibility, was a menace not only to the nation's body politic but also to its democratic soul. If allowed to proceed unimpeded, the pope and his minions, along with Tammany's bosses and supporters, would convert the nation into their personal fiefdom. Puck was not about to let that happen. In cartoons and editorials spanning two decades, the magazine blasted and often conjoined both Tammany and the papacy with invidious comparisons that left few readers in doubt as to their complicity. Although scholars have noted how the American letterpress also alluded to a connection between Tammany and the Catholic church, Puck's unparalleled comprehensive strategy to perpetuate and strengthen that connection has never been scrutinized. This essay redresses that oversight of an age when the public and its politicians reckoned very seriously the editorial artistry of great political cartoonists, especially those who drew for Puck.
15

Jones, John A., and Virginia H. Jones. "Party Games: Getting, Keeping, and Using Power in Gilded Age Politics (review)." Rhetoric & Public Affairs 9, no. 2 (2006): 318–21. http://dx.doi.org/10.1353/rap.2006.0045.

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Carpentier, Vincent, David Giazzon, Cyril Marcigny, and Emmanuel Ghesquière. "Aspects de la vie domestique et agricole médiévale aux confins de la Normandie et du Maine : Le site d’Arçonnay « Parc Saint-Gilles » (Sarthe) Autour du xiie siècle." Revue archéologique de l'Ouest, no. 26 (December 31, 2009): 229–58. http://dx.doi.org/10.4000/rao.924.

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17

Bueno Alonso, Jorge Luis. "“Scealcas of sceaðum scirmæled swyrd”: Analysing Judith’s Language and style in translation through a key sample case (161b-166a) and a twin coda (23 & 230)." Revista Alicantina de Estudios Ingleses, no. 26 (November 15, 2013): 213. http://dx.doi.org/10.14198/raei.2013.26.15.

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Among the extant texts from the Old English poetic corpus that have survived up till now –Beowulf aside–, Judith constitutes a poem in which the poet “wrinkles up” the text outstandingly in order to, as Griffith (1997: 85) stated, show a new purpose for commonplace aspects of Old English poetic style. By considering a key sample case (lines 161b-166a) and a further two specific examples (lines 23 & 230), the aim of this article is to revise and analyze how Judith’s poetic and textual wrinkles –especially those affecting language and style, so important to explain the poem’s singular status– have been dealt with in several translations into English that cover a wide array of translation types: pioneer/philological [Cook 1889, through Barber 2008, and Gordon 1926], classic/academic [Hamer 1970 & Bradley 1982], recent/updated both complete [North, Allard and Gillies 2011 & Treharne 2010] and fragmentary [Constantine 2011]. I will always offer my own solutions to the problems raised by the text as presented in my alliterative verse translation into Spanish (Bueno & Torrado 2012).
18

Armitage, Allan M., Linda Copeland, Paula Gross, and Meg Green. "Cold Storage and Moisture Regime Influence Flowering of Oxalis adenophylla and Ipheion uniflorum." HortScience 31, no. 7 (December 1996): 1154–55. http://dx.doi.org/10.21273/hortsci.31.7.1154.

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Rhizomes of Oxalis adenophylla Gillies and bulbs of Ipheion uniflorum Raf. were planted and wet- or dry-stored at 5 °C for 0, 6, 10, 14, or 18 weeks, before being placed in a greenhouse. Regardless of moisture regime, foliage emergence and time to flower decreased for both species with increasing duration of cooling. Wet-stored bulbs/rhizomes within a cooling treatment required less time to foliage and flower emergence when compared with the corresponding dry-storage period. About 10 weeks of 5 °C was optimum for both species.
19

Hulsether, Lucia. "The Parliament of Empire: Charles Bonney's American Vision." Religion and American Culture 29, no. 1 (2019): 102–33. http://dx.doi.org/10.1017/rac.2018.2.

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ABSTRACTThis article places the World's Parliament of Religions in its social-political milieu of Gilded Age Chicago. It takes up the Parliament not to rehash arguments that scholars have made about its particular performance of religion but, rather, to locate its pluralist production in finer-grained material expenditures and extractions that made it possible. It tells this story through an examination of the Parliament's organizer, Charles Carroll Bonney. Employed as a federal judge in Chicago, Bonney's life reflects the coterminous boundaries of capital, state-building, and aspirations for the reconciliation of human conflict through multireligious unity. His tenure as the organizer of the Parliament, and as the President of the World Congress Auxiliary of which it was a part, was riddled by raging conflict with Chicago's union leaders, who saw the events as an indirect attack on the city's labor movement. To analyze the Parliament in light of these factors is to begin to understand the history of American religious pluralism as constituted by—and, thus, inextricable from—histories of labor, capital, and the state.
20

Haile, A. T., T. Rientjes, E. Habib, and V. Jetten. "Rain event properties and dimensionless rain event hyetographs at the source of the Blue Nile River." Hydrology and Earth System Sciences Discussions 7, no. 4 (August 17, 2010): 5805–49. http://dx.doi.org/10.5194/hessd-7-5805-2010.

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Abstract. In the present study, the spatial and temporal patterns of the rain event properties are analysed. The event properties are rain event depth, event duration, mean event intensity, peak intensity and the time span between two consecutive rain events which is referred to as inter-event time (IET). Dimensionless event hyetographs are established by relating fractions of event intensities to the corresponding fractions of event durations. The spatial variation of the characteristics of the hyetographs is also evaluated. A model in the form of the beta distribution function is applied to reproduce the dimensionless hyetographs. Rainfall data is obtained from a field campaign in two wet seasons of June–August (JJA) of 2007 and 2008 in the Gilgel Abbay watershed that is situated at the source basin of the upper Blue Nile River in Ethiopia. The rainfall data was recorded at eight stations. The results reveal that rain event depth is more related to peak intensity than to event duration. At the start and towards the end of the wet season, the rain events have larger depth with longer duration and longer IET than the rain events in the mid-season. Mean event intensity and IET are strongly related to terrain elevation. Sekela which is on a mountain area has the shortest IET while Bahir Dar which is at the south shore of the lake has the longest IET.
21

Jacobs, Nancy. "Cutting the Vines of the Past: Environmental Histories of the Central African Rain Forest Tamara Giles-Vernick." Public Historian 26, no. 2 (April 2004): 111–13. http://dx.doi.org/10.2307/3379707.

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22

Drucker, Donna J. "An “Aristocracy of Virtue”: Cultural Development of the American Catholic Priesthood, 1884–1920s." Religion and American Culture: A Journal of Interpretation 21, no. 2 (2011): 227–58. http://dx.doi.org/10.1525/rac.2011.21.2.227.

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AbstractThis article examines advice literature directed at English-speaking members of the American Catholic priesthood in the Gilded Age and Progressive Era. From the Third Plenary Council of Baltimore in 1884 through the late 1920s, advice literature transformed from emphasizing how the priest should be a man set above the laity into emphasizing how the priest should be part of a broad priestly fraternity, taking on the role of a public citizen speaking out on issues of the day. After the modernist controversies of the first decade of the twentieth century that stifled their intellectual development, American priests’ seminary training particularly emphasized virile masculinity, athletic rigor, and duty and conformity to their superiors. In the late nineteenth century, advice literature encouraged priests to see their lives together in rectories as schools of charity, where all of the priests would, with the assistance of obedient and nonthreatening household staff, encourage each other to be men of prayer and self-sacrifice despite each others’ individual foibles. Every aspect of a priest's life, from the rectory environment to his clothing and bearing, was supposed to mark him as a man set apart. During and after World War I, however, advice literature shifted from addressing the priest's life in his rectory and parish alone to encouraging him to participate in civic duties as an American citizen. Diocesan priests like John A. Ryan took a lead role in advocating for social reforms that married public policy with social and economic justice. While priests’ sacramental duties remained at the center of their lives and ministries, advice literature nonetheless encouraged them to rethink their place in the sociocultural landscape and to become more vocal promoters of Catholic values in the public sphere.
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Giocoli, Nicola. "The (Rail)Road to Lochner : Reproduction Cost and the Gilded Age Controversy over Rate Regulation." History of Political Economy 49, no. 1 (February 28, 2017): 31–58. http://dx.doi.org/10.1215/00182702-3777146.

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Minué, Carlos R., and Adriel I. Jocou. "The genus Sesuvium (Aizoaceae, Sesuvioideae) in the Southern Cone." Hacquetia 20, no. 1 (March 1, 2021): 33–48. http://dx.doi.org/10.2478/hacq-2021-0006.

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Abstract Sesuvium is a genus of 14 to 17 species of succulent plants, both annual and perennial, widely distributed in tropical and subtropical regions. The genus Sesuvium has not yet been studied in detail in the Southern Cone (Argentina, Southern Brazil, Chile, Paraguay and Uruguay), which has led to a misidentification of numerous specimens as S. portulacastrum. As part of the ongoing floristic, taxonomic and ecologic studies in Argentina, we revise the genus Sesuvium for the Southern Cone. This study is based on field investigation, examination of herbarium specimens, and revision of literature. The taxonomic treatments, maps of distribution, detailed descriptions, photographs, an illustration, a dichotomous key and a comparative table to differentiate the species of the genus Sesuvium occurring in the Southern Cone are presented. Finally, ecological, morphological, and taxonomic aspects of the species are discussed. The new combination of S. americanum (≡ Trianthema americanum Gillies ex Arn.; = S. verrucosum Raf.) is proposed. Lectotypes for three names are here designated (S. revolutifolium Vahl ex Willd.; S. revolutifolium Lam., and S. parviflorum DC.). Four species should be accepted for the Southern Cone: S. americanum, S. humifusum, S. mezianum and S. sessile. Furthermore, S. portulacastrum is excluded from the flora of the Southern Cone.
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Manso, Marta, Ana Bidarra, Stéphane Longelin, Sofia Pessanha, Adriana Ferreira, Mauro Guerra, João Coroado, and Luísa Carvalho. "Micro-Analytical Study of a Rare Papier-Mâché Sculpture." Microscopy and Microanalysis 21, no. 1 (September 15, 2014): 56–62. http://dx.doi.org/10.1017/s1431927614013129.

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AbstractThe analysis of a Portuguese “papier-mâché” sculpture depicting Saint Anthony is presented in this case study. Several questions were addressed such as the characteristics of the support, pigments used, and artistic technique in order to establish a possible timeline for its production. Qualitative analyses of the cross-sections and of the paper support were performed by optical microscopy using reflected light. Two polychrome layers from different periods and a rag pulped support were identified on the sculpture. The use of micro X-ray fluorescence and Raman microscopy techniques enabled the differentiation of coloring materials used in both polychromies. Semi-quantitative analyses of the gilded samples were also performed by scanning electron microscopy in combination with energy-dispersive spectroscopy allowing the determination of a common Au–Ag–Cu alloy with differences in the purity of the gold. The identified coloring materials lead us to believe that the sculpture was produced in the 19th century, being overpainted in the first half of the 20th century.
26

Byadgi, Omkar, Fabio Marroni, Ron Dirks, Michela Massimo, Donatella Volpatti, Marco Galeotti, and Paola Beraldo. "Transcriptome Analysis of Amyloodinium ocellatum Tomonts Revealed Basic Information on the Major Potential Virulence Factors." Genes 11, no. 11 (October 24, 2020): 1252. http://dx.doi.org/10.3390/genes11111252.

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The ectoparasite protozoan Amyloodinium ocellatum (AO) is the etiological agent of amyloodiniosis in European seabass (Dicentrarchus labrax) (ESB). There is a lack of information about basic molecular data on AO biology and its interaction with the host. Therefore, de novo transcriptome sequencing of AO tomonts was performed. AO trophonts were detached from infested ESB gills, and quickly becoming early tomonts were purified by Percoll® density gradient. Tomont total RNA was processed and quality was assessed immediately. cDNA libraries were constructed using TruSeq® Stranded mRNA kit and sequenced using Illumina sequencer. CLC assembly was used to generate the Transcriptome assembly of AO tomonts. Out of 48,188 contigs, 56.12% belong to dinophyceae wherein Symbiodinium microadriaticum had 94.61% similarity among dinophyceae. Functional annotations of contigs indicated that 12,677 had associated GO term, 9005 with KEGG term. The contigs belonging to dinophyceae resulted in the detection of several peptidases. A BLAST search for known virulent factors from the virulence database resulted in hits to Rab proteins, AP120, Ribosomal phosphoprotein, Heat-shock protein70, Casein kinases, Plasmepsin IV, and Brucipain. Hsp70 and casein kinase II alpha were characterized in-silico. Altogether, these results provide a reference database in understanding AO molecular biology, aiding to the development of novel diagnostics and future vaccines.
27

Haile, A. T., T. H. M. Rientjes, E. Habib, V. Jetten, and M. Gebremichael. "Rain event properties at the source of the Blue Nile River." Hydrology and Earth System Sciences 15, no. 3 (March 24, 2011): 1023–34. http://dx.doi.org/10.5194/hess-15-1023-2011.

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Abstract. In the present study, spatial and temporal patterns of rain event properties are analysed. These event properties are rain event depth, event duration, mean event rain rate, peak rain rate and the time span between two consecutive rain events which is referred to as inter-event time (IET). In addition, we assessed how rain event properties change when the period over which rainfall data is aggregated changes from 1 to 6 min and when the minimum inter-event time (MIT) changes from 30 min to 8 h. Rainfall data is obtained from a field campaign in two wet seasons of June–August (JJA) of 2007 and 2008 in Gilgel Abbay watershed that is situated at the source basin of the Upper Blue Nile River in Ethiopia. The rainfall data was automatically recorded at eight stations. The results revealed that rain event depth is more related to peak rain rate than to event duration. At the start and towards the end of the wet season, the rain events have larger depth with longer duration and longer IET than those in mid-season. Event rain rate and IET are strongly related to terrain elevation. Sekela which is on a mountain area has the shortest IET while Bahir Dar which is at the south shore of Lake Tana has the longest IET. The period over which rainfall data is aggregated significantly affected the values of rain event properties that are estimated using relatively small value (30 min) of MIT but its effect diminished when the MIT is increased to 8 h. It is shown that increasing the value of MIT has the largest effect on rain event properties of mountain stations that are characterised by high rainfall intermittency.
28

Oda, FH, DK Petsch, FH Ragonha, VG Batista, AM Takeda, and RM Takemoto. "Dero (Allodero) lutzi Michaelsen, 1926 (Oligochaeta: Naididae) associated with Scinax fuscovarius (Lutz, 1925) (Anura: Hylidae) from Semi-deciduous Atlantic Rain Forest, southern Brazil." Brazilian Journal of Biology 75, no. 1 (March 2015): 86–90. http://dx.doi.org/10.1590/1519-6984.07613.

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Amphibians are hosts for a wide variety of ecto- and endoparasites, such as protozoans and parasitic worms. Naididae is a family of Oligochaeta whose species live on a wide range of substrates, including mollusks, aquatic macrophytes, sponges, mosses, liverworts, and filamentous algae. However, some species are known as endoparasitic from vertebrates, such as Dero (Allodero) lutzi, which is parasitic of the urinary tracts of frogs, but also have a free-living stage. Specimens in the parasitic stage lack dorsal setae, branchial fossa, and gills. Here we report the occurrence of D. (A.) lutzi associated with anuran Scinax fuscovarius from Semi-deciduous Atlantic Rain Forest in southern Brazil. The study took place at the Caiuá Ecological Station, Diamante do Norte, Paraná, southern Brazil. Seven specimens of S. fuscovarius were examined for parasites but only one was infected. Parasites occurred in ureters and urinary bladder. Previous records of this D. (A.) lutzi include the Brazilian States of Santa Catarina, São Paulo, Rio de Janeiro, and Minas Gerais, as well as Cuba and North America. This is a new locality record for this species in Brazil. Reports of Dero (Allodero) lutzi are rare, due to difficulty of observation, and such events are restricted only the fortuitous cases. It is important to emphasize the necessity of future studies, which are fundamental to the understanding of biological and ecological aspects of this species.
29

Otieno, Alphonse. "BOOK REVIEW: Tamara Giles-Vernick. CUTTING THE VINES OF THE PAST: ENVIRONMENTAL HISTORIES OF THE CENTRAL AFRICAN RAIN FOREST. Charlottesville: University of Virginia Press. 2002." Africa Today 50, no. 4 (June 2004): 129–32. http://dx.doi.org/10.2979/aft.2004.50.4.129.

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MacGaffey, Wyatt. "Cutting the Vines of the Past: Environmental Histories of the Central African Rain Forest. By Tamara Giles-Vernick (Charlottesville, University Press of Virginia, 2002) 293 pp. $49.50 cloth $19.95 paper." Journal of Interdisciplinary History 34, no. 4 (April 2004): 671–72. http://dx.doi.org/10.1162/jinh.2004.34.4.671.

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31

Jones, D. R., R. W. Brill, and P. G. Bushnell. "VENTRICULAR AND ARTERIAL DYNAMICS OF ANAESTHETISED AND SWIMMING TUNA." Journal of Experimental Biology 182, no. 1 (September 1, 1993): 97–112. http://dx.doi.org/10.1242/jeb.182.1.97.

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Cardiovascular dynamics of tuna have been investigated by recording blood pressures and flows in the central circulation of both anaesthetised and swimming individuals. In anaesthetised fish (N=5), heart rate averaged 112+/−21 beats min-1 (mean +/− s.e.) and stroke volume was 0.67+/−0.24 ml kg-1 when normoxic water flowed over the gills. Ventricular diastolic pressure was zero until atrial contraction filled the ventricle. Ventral aortic pressures were high (mean 12.08+/−1.15 kPa), and blood flow was continuous in the ventral aorta throughout diastole. Dorsal aortic pressure (mean 6.3+/−1.28 kPa; N=4) and flow were both pulsatile. Pressure pulsatility (pulse pressure as a proportion of mean pressure) was about one-quarter of flow pulsatility, indicating considerable compliance in the dorsal aortic circulation. Total peripheral resistance averaged 0.17+/−0.4 kPa ml-1 kg-1 min-1 of which gill resistance averaged 48+/−15 % (N=4). For the ventral aorta, impedance modulus fell markedly from the mean value and then declined more gradually towards zero with increasing harmonic frequencies. Impedance phase was negative (−0.8 to −1.1 rad) meaning that flow leads pressure at all harmonics. In swimming yellowfin tuna (N=5), heart rate averaged 108.8+/−12.1 beats min-1 and mean ventral and dorsal aortic pressures were 11.6+/−0.5 and 6.8+/−1.2 kPa, respectively, so gill resistance was 42 % of total peripheral resistance. Average stroke volume in three swimming kawakawa was 0.54+/−0.2 ml kg- 1 at a mean heart rate of 128+/−48 beats min-1. Data from swimming fish were within the range obtained from anaesthetised tuna. A simple model of the fish circulation consisting of two sets of compliant and resistive elements coupled in series (a second-order RC network) gave reasonable predictions of arterial pressure-flow relationships. Hence, we conclude that a ‘Windkessel’ dominates central cardiovascular dynamics of tuna despite heart rates and blood pressures that fall in the mammalian range.
32

KITLV, Redactie. "Book reviews." Bijdragen tot de taal-, land- en volkenkunde / Journal of the Humanities and Social Sciences of Southeast Asia 165, no. 1 (2009): 129–89. http://dx.doi.org/10.1163/22134379-90003646.

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Johnny Tjia; A grammar of Mualang: An Ibanic language of West Kalimantan, Indonesia (Alexander Adelaar) Christopher Moseley (ed.); Encyclopedia of the world’s endangered languages (Peter K. Austin) Ian Rae and Morgen Witzel; The Overseas Chinese of South east Asia: History, culture, business (Chin Yee Whah) Ab Massier; The voice of the law in transition: Indonesian jurists and their languages, 1915-2000 (Dwi Noverini Djenar) Henk Schulte Nordholt and Gerry van Klinken (eds); Renegotiating boundaries: Local politics in post-Suharto Indonesia (Maribeth Erb) Nghia M. Vo; The Vietnamese boat people, 1954 and 1975-1992 (Martin Grossheim) O.W. Wolters; Early Southeast Asia: Selected essays [edited by Craig J. Reynolds] (Hans Hägerdal) Michael W. Scott; The severed snake: Matrilineages, making place, and a Melanesian Christianity in Southeast Solomon Islands (Menno Hekker) John H. McGlynn, Oscar Motuloh, Suzanne Charlé, Jeffrey Hadler, Bambang Bujono, Margaret Glade Agusta, and Gedsiri Suhartono; Indonesia in the Soeharto years: Issues, incidents and images (David Henley) Hanneke Hollander; Een man met een speurdersneus: Carel Groenevelt (1899-1973), beroepsverzamelaar voor Tropenmuseum en Wereldmuseum in Nieuw-Guinea (Anna-Karina Hermkens) Balk, G.L., F. van Dijk and D.J. Kortlang (with contributions by F.S. Gaastra, Hendrik E. Niemeijer and P. Koenders); The Archives of the Dutch East India Company (VOC) and the local institutions in Batavia (Jakarta) (Ton Kappelhof) Gusti Asnan; Memikir ulang regionalisme: Sumatera Barat tahun 1950-an (Gerry van Klinken) Lise Lavelle; Amerta Movement of Java 1986-1997: An Asian movement improvisation (Dick van der Meij) Nicole-Claude Mathieu (ed.); Une maison sans fille est une maison morte: La personne et le genre en sociétés matrilinéaires et/ou uxorilocales (Joke van Reenen) Henk Schulte Nordholt; Indonesië na Soeharto: Reformasi en restauratie (Elske Schouten) V.I. Braginsky; … and sails the boat downstream: Malay Sufi poems of the boat (Suryadi) Gilles Gravelle; Meyah: An east Bird’s Head language of Papua, Indonesia (Ian Tupper) Penny Edwards; Cambodge: The cultivation of a nation, 1860-1945 (Un Leang) J. Stephen Lansing; Perfect order: Recognizing complexity in Bali (Carol Warren) Roxana Waterson (ed.); Southeast Asian lives: Personal narratives and historical experience (C.W. Watson) Jean DeBernardi; The way that lives in the heart: Chinese popular religion and spirit mediums in Penang, Malaysia (Robert Wessing) REVIEW ESSAY Environmental and archaeological perspectives on Southeast Asia Peter Boomgaard; Southeast Asia: An environmental history Peter Boomgaard (ed.); A world of water: Rain, rivers and seas in Southeast Asian histories Ian Glover and Peter Bellwood (eds); Southeast Asia: From prehistory to history Avijit Gupta (ed.); The physical geography of Southeast Asia (Eric C. Thompson)
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Klieman, Kairn A. "Tamara Giles-Vernick. Cutting the Vines of the Past: Environmental Histories of the Central African Rain Forest. Charlottesville: University Press of Virginia, 2002. xiii + 293 pp. Map. Photographs. Appendixes. Glossary. Bibliography. Index. No price reported. Cloth." African Studies Review 47, no. 1 (April 2004): 224–26. http://dx.doi.org/10.1017/s0002020600027074.

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Goja, Bojan. "Pietro Sandrioli indorador iz Venecije i drvene oltarne pale u Rabu i Šibeniku." Ars Adriatica, no. 3 (January 1, 2013): 159. http://dx.doi.org/10.15291/ars.467.

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Based on new archival research, the article focuses on previously unknown information about wooden altarpieces in Rab and Šibenik. The documents created by the Rab notary Ivan Božidar Kašić, which are keptin the State Archive at Zadar, contain a contract about the making of a wooden superstructure (palla) for the high altar in the Church of St. Andrew and its original altar painting. The contract bears the date of 19 April 1623 and obliges Piero Sandrioli, an indorador and resident of Zadar, to make an altarpieces according to a set design, fifteen-feet high and nine-and-a-half-feet wide, together with a canvas painting of the Blessed Virgin Mary and paintings depicting the scenes of the Most Holy Rosary. He was required to paint the figure of St. Dominic to the right of the Virgin, the figure of St. Catherine of Siena to her left, and, next to the Virgin’s feet at the bottom of the painting, the scenes on the topic of the Most Holy Rosary. The rest of the altarpieces had to correspond to the aforementioned design in all respects. The whole structure (probably referring to the wooden superstructure and the painting) had to be carved, delivered to the Church of St. Andrew and set up on the altar at the expense of Pietro Sandrioli. Once in Rab, after the delivery of the wooden altarpiece and the painting, Sandrioli was also required to gild the altarpiece. The entire task had to be completed by the following December. As soon as the work was completed, Sandrioli was to be paid the amount of 250 ducats and here it is mentioned that he had already received 360 lire. Apart from the described altar superstructure from Rab, the same mistro Pietro Sandrioli da Venecia indorador is mentioned in connection to the making of the former high altar in the Church of St. Dominic at Šibenik. This document of 13 June 1628 has been preserved in the records of the Šibenik notary Ante Vrančić which are also kept in the State Archive at Zadar. The document states that Lorenzo Corradis, a representative and intermediary on behalf of the confraternity of the Virgin of the Most Holy Rosary from the Church of St. Dominic, paid Pietro Sandrioli, the indorador of Venice, 376 lire which is also confirmed by a receipt issued for the services of carving and painting undertaken in Venice for the wooden high altar of the Virgin of the Most Holy Rosary.As confirmed by Pietro Sandrioli himself, only 180 of those 376 lire had been spent and he owed Lorenzo Corradis the amount of 196 lire. In other words, he owed him the amount which could be somewhat higher or lower than the stated sum but which would correspond to the amount of money that was actually spent. The next step was to see a Venetian notary who was to issue Corradis with a confirmation that the amount of 180 lire was spent to pay for the work of the master craftsman, and this would guarantee that the money was indeed spent. For this purpose, the indorador Pietro Sandrioli, in the company of the aforementioned witnesses, promised and committed to provide a trustworthy and original confirmation issued by a Venetian notary in which these master carvers and painters would state the exact cost of their work while under oath. Then, he would bring or send this confirmation from Venice by the end of the following January. In the event of Sandrioli’s failure to send or bring the confirmation by the end of the following January, he was to be replaced by another master indorador, Zuanne Voicovich, who would be responsible for the payment of the 196 lire in full. Although this document merely regulates some expenditures, it can still be used to establish that the work on the wooden high altar for the Church of St. Dominic at Šibenik was begun before 13 June 1628 when, it seems, it was still ongoing; that the majority of work was done in Venice, and that the indoradori Pietro Sandrioli and Zuanne Voicovich were involved in the production together with numerous unnamed master wood-carvers and painters. It may be concluded that Sandrioli and Voicovich were at that time in Šibenik together, and that they worked on the completion of the altar, decorating it with gilding. Since Pietro Sandrioli was mentioned in the Rab document of 1623 as a resident of Zadar, it can be suggested with a high degree of certainty that he worked for the commissioners who were based in the capital of Dalmatia and its environments. In Venice, the term indoradóri or doradóri denoted those craftsmen who used gold or silver foils to decorate various hand-made objects, most frequently those made of wood. The Indoradóri did not have a guild of their own but formed one of the branches of the confraternity of painters, a member ofwhich, between 1597 and 1610, was a certain Piero de Zen Sandrioli, probably the same master craftsman who worked on the wooden altarpieces at Rab and Šibenik. On the basis of the analysis of archival records and other examples of the production of carved and gilded wooden altars in seventeenth-century Venice and Dalmatia, it is concluded that the making of the wooden altar superstructure from Rab was a task shared by a number of master craftsmen who specialized in the various aspects of carpentry such as the marangoni, tornitori, figuristi, ornatisti and indoradori. Pietro Sandrioli, apart from being responsible for the tasks of an indorador, probably acted as an intermediary of sorts between them and the commissioners. After Pietro Salamone (Hvar, Zadar) and Jacopo Costantini (Trogir), Pietro Sandrioli is the third Venetian indorador to have worked for Dalmatian patrons in the late sixteenth and the early decades of the seventeenth century. Since the indorador Costantini also made the canvas painting of the Virgin and Child with St. Dominic and a donor for the wooden altar in the Dominican church at Trogir, it can be assumed that the indorador Sandrioli may have also been responsible for the painting of the now lost Virgin of the Most Holy Rosary with SS Dominic and Catherine of Siena, which was inset in the wooden altar superstructure of the main altar of the Church of St. Andrew.
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Pinho, Davi. "O CONTO DE VIRGINIA WOOLF – OU FICÇÃO, UMA CASA ASSOMBRADA." IPOTESI – REVISTA DE ESTUDOS LITERÁRIOS 23, no. 2 (December 4, 2019): 03–17. http://dx.doi.org/10.34019/1982-0836.2019.v23.29176.

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O presente artigo se debruça sobre o conto “Casa Assombrada”, coletado no único volume de contos que Virginia Woolf publicou em vida, Monday or Tuesday (1921), para investigar de que maneira seus contos intensificam a crise dos gêneros literários que seus romances encenam, por um lado; e para entender como tal crise é análoga à questão política que assombra toda sua obra, por outro lado: o gênero enquanto questão identitária. Em diálogo com a filosofia e com a crítica woolfiana, este estudo articula essa “crise dos gêneros” (gender x genre) e, ao mesmo tempo, produz uma contextualização histórico-cultural dos contos de Virginia Woolf. Palavras-chave: Virginia Woolf. Conto. Gênero literário. Questões de gênero. Referências AGAMBEN, Giorgio. Elogio da profanação. In: AGAMBEN, Giorgio. Profanações. Tradução Selvino Assman. São Paulo: Boitempo, 2007. p. 65-81 BENJAMIN, Walter. Sobre a linguagem em geral e sobre a linguagem humana. In: Linguagem, tradução, literatura. Tradução João Barrento. Belo Horizonte: Autêntica, 2018 [1916]. p. 9-27. BENZEL, Kathryn N.; HOBERMAN, Ruth. Trespassing boundaries: Virginia Woolf’s Short Fiction. New York: Palgrave MacMillan, 2004. BRAIDOTTI, Rosi. Nomadic theory: The portable Rosi Braidotti. New York: Columbia University, 2011. BRIGGS, Julia. Virginia Woolf, an Inner Life. Londres: Harcourt Brace, 2005. CIXOUS, Hélène. First names of no one. In: SELLERS, Susan (org.). The Hélène Cixous Reader. Londres: Routledge, 1994 [1974]. p. 25-35. DELEUZE, Gilles; GUATTARI, Félix. 28 de novembro de 1947 – Como criar para si um corpo sem órgãos?. Tradução Aurélio Guerra Neto. In: DELEUZE, Gilles; GUATTARI, Félix. Mil Platôs. São Paulo: 34, 1996 [1980]. v. 3. p. 11-34. FOUCAULT, Michel. Docile bodies. In: FOUCAULT, Michel; RABINOW, Paul (ed.). The Foucault reader. Toronto: Penguin, 1984a. p. 179-187. FOUCAULT, Michel. The body of the condemned. In: FOUCAULT, Michel; RABINOW, Paul (ed.). The Foucault reader. Toronto: Penguin, 1984b. p. 170-178. GOLDMAN, Jane. Modernism, 1910-1945, Image to apocalypse. Basingstoke: Palgrave Macmillan, 2004. GOLDMAN, Jane. The Cambridge introduction to Virginia Woolf. Cambridge: Cambridge University, 2006. HARRIS, Wendell. Vision and form: the English novel and the emergence of the story. In: MAY, Charles (ed.). The new short story theories. Athens, Ohio: Ohio University, 1994. p. 181-191. KRISTEVA, Julia. Stabat mater. Tradução A. Goldhammer. In: MOI, Toril (ed.). The Kristeva reader. Oxford: Blackwell, 1986 [1977]. p. 160-187. MATTHEWS, Brander. The philosophy of the short-story. Londres: Forgotten, 2015. [1901]. PEREIRA, Lucia Miguel. Dualidade de Virginia Woolf. In: ______. Escritos da maturidade. Rio de Janeiro: Graphia, 2005. [1944] p. 106-110. SELLERS, Susan (ed.). The Cambridge Companion to Virginia Woolf. 2. ed. Cambridge: Cambridge University, 2010. WOOLF, Leonard. Beginning again: an autobiography of the years 1911 to 1918. New York: Harvest, 1975. [1964] WOOLF, Leonard. Editorial Preface. In: WOOLF, Virginia; WOOLF, Leonard (eds.). Granite and rainbow. Londres: Harcourt, 1958. p. 7-8. WOOLF, Leonard. Foreword. In: WOOLF, Virginia; WOOLF, Leonard (eds.). A haunted house and other stories. Londres: Harcourt, 1944. p. v-vi. WOOLF, Virginia. A haunted house. In: WOOLF, Virginia; WOOLF, Leonard (eds.). A haunted house and other stories. Londres: Harcourt, 1944 [1921]. p. 3-5. WOOLF, Virginia. A room of one’s own & Three guineas. Londres: Oxford University, 1992 [1929] [1938]. WOOLF, Virginia. A sketch of the past. In: WOOLF, Virginia; SCHULKIND, Jeanne (eds.). Moments of being. London: Harcourt Brace, 1985 [1976]. p. 64-159. WOOLF, Virginia. Casa assombrada. In: WOOLF, Virginia. Contos completos. Tradução Leonardo Fróes. São Paulo: Cosac Naify, 2005 [1921]. p. 162-165. WOOLF, Virginia. Granite and rainbow, ed. Leonard Woolf. Londres: Harcourt, 1958. WOOLF, Virginia. Jacob’s room. Oxford: Oxford University, 2008 [1922]. WOOLF, Virginia. Kew gardens. In: WOOLF, Virginia; WOOLF, Leonard (eds.). A haunted house and other stories. Londres: Harcourt, 1944 [1919]. p. 28-36. WOOLF, Virginia. Men and women. In: WOOLF, Virginia; BARRETT, Michele (eds.). Women and writing. Londres: Harcourt, 1979 [1920]. p. 64-68. WOOLF, Virginia. Modern fiction. In: WOOLF, Virginia. The common reader: first series. Londres: Vintage, 2003 [1925]. p. 146-154. WOOLF, Virginia. Monday or Tuesday. Londres: The Hogarth, 1921. WOOLF, Virginia. Night and day. ed. Michael Whitworth. Cambridge: Cambridge University, 2018. WOOLF, Virginia. Professions for women. In: WOOLF, Virginia; WOOLF, Leonard (eds.). The death of the moth and other essays. Londres: Harcourt, 1942 [1931]. WOOLF, Virginia. The complete shorter fiction of Virginia Woolf. ed. Susan Dick. Orlando: Harcourt, 2006 [1985]. WOOLF, Virginia. The diary of Virginia Woolf, ed. Anne Olivier Bell, 5 vols. New York: Penguin, 1979-1985 [1977-1984]. WOOLF, Virginia. The letters of Virginia Woolf, ed. Nigel Nicolson, 6 vols. Londres: The Hogarth, 1975-1980. WOOLF, Virginia. The mark on the wall. In: WOOLF, Virginia; WOOLF, Leonard (eds.). A haunted house and other stories. Londres: Harcourt, 1944 [1921]. p. 37-47. WOOLF, Virginia. Thoughts on peace in an air raid. In: ______. The death of the moth and other essays, ed. Leonard Woolf. Londres: Harcourt Brace Jovanovich, 1942. [1940] WOOLF, Virginia. The voyage out. Oxford: Oxford University, 2009 [1915]. WOOLF, Virginia. The waves. Oxford: Oxford University, 1992 [1931].
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CASTRYCK, GEERT. "MIND AND FOREST OVER THE TWENTIETH CENTURY Cutting the Vines of the Past: Environmental Histories of the Central African Rain Forest. By TAMARA GILES-VERNICK. Charlottesville: University Press of Virginia, 2002. Pp. xiii+293. £37.95 (ISBN 0-8139-2102-3); £14.95, paperback (ISBN 0-8139-2103-1)." Journal of African History 45, no. 3 (November 2004): 512–13. http://dx.doi.org/10.1017/s0021853704349935.

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الأردن, مكتب المعهد في. "عروض مختصرة." الفكر الإسلامي المعاصر (إسلامية المعرفة سابقا) 8, no. 29 (July 1, 2002): 158–47. http://dx.doi.org/10.35632/citj.v8i29.2847.

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الجماعات الوظيفية اليهودية: نموذج تفسيري جديد. عبد الوهاب المسيري. القاهرة: دار الشروق، 2002م، ص551. الفلسفة المادية وتفكيك الإنسان. عبد الوهاب المسيري. دمشق: دار الفكر، 2002م، 240 ص. اليهودية بين حضانة الشرق الثقافية وحضانة الغرب السياسية. عفيف فراج، بيروت: دار الآداب، 2002م، 232 ص ديني مدارس مين تعليم: كيفيت، مسائل، امكانات. سليم منصور خالد. إسلام أباد، باكستان: المعهد العالمي للفكر الإسلامي ومركز دراسات السياسة، 2002م، 471 ص. Hyperterrorisme: La Nouvelle Guerre. Francois Heisbourg. Paris : Odile Jacob. 2001, 270 pages. Les Ennemis des Philosophes: L’antiphilosophie au Temps des Lumières. Didier Masseau. Paris : Ēdidions Albin Michel, 2000, 456 pages. A History of Censorship in Islamic Societies. Trevor Mostyn. London: Saqi Books, 2002, 240 pp. A Concise Encyclopedia of Islam. Godon Newby. Oneworld Publications, 2002, 288pp. A Problem from Hell: America and the Age of Genocide. Samantha Power. Basic Books, Feb. 2002, 640 pp American Muslims: Bridging Faith and Freedom. M.A. Muqtedar Khan. MD: amana publications, 2002, 194 pp. Awqaf Experiences in South Asia. Syed Khalid Rashid (ed.). New Delhi: Institute of Objective Studies, 2002, 634 pp. Believing as Ourselves. J. Lynn Jones, Jeffrey Lang, Michael Mumisa. MD: Amana Publications, 2002, 160 pp BIAS: A CBS Insider Exposes How the Media Distort the News. Bernard Goldberg. 2002, 232 pp. Betting on America: Why the US can be Stronger After September 11. James W. Cortada, Edward Wakin, Financial Times-Prentice Hall Books, 2002, 274 pp. Black Pilgrimage to Islam. Robert Dannin. New York: Oxford University Press, Inc., 2002, 328 pp. Chemical and Biological Warfare: A Comprehensive Survey for the Concerned Citizen. Eric Croddy. Copernicus books, Dec. 2001, 352 pp Crossing the Green Line between the West Bank and Israel. Avram Bornstein. University of Pennsylvania Press. Nov. 2001, 184 pp. Everything You Know is Wrong: The Disinformation Guide to Secrets & Lies. Russ Kick (editor). New York: The Disinformation Co. Ltd., 2002, 346 pp. . Fixing Elections: The Failure of America’s Winner-Take-All Politics. Steven Hill. Taylor and Francis, Inc. June 2002, 363 pp. Inside Islam: The Faith, the People and the Conflicts of the World’s Fastest-Growing Religion. John Miller (editor) and Aaron Kenedi (editor). Avalon Publishing Group. 2002, 366 pp. Islam: Faith, Culture, History. Paul Lunde. DK Publishing, Inc., 2002, 176 pp. Islam: Origins. Practices. Holy Texts. Sacred Persons. Sacred Places. Mathew S. Gordon, NY: Oxford University Press Inc., 2002, 112 pp. Legacy of the Prophet: Despots, Democrats, and the New Politics of Islam. Anthony Shadid. Westview Press, March 2002, 352 pp. On Two Wings: Humble Faith and Common Sense at the American Founding. Michael Novak. San Francisco: Encounter Books, 2002, 235 pp. . Reporting Islam: Media Representations and British Muslims. Elizabeth Poole. I.B. Tauris & Company Limited, 2002, 240 pp. September 11: Religious Perspectives on the Causes and Consequences. Ian Markham and Ibrahim Abu-Rabi’ (ed.). Oxford: Oneworld Publications, 2002, 292 pp. Speaking in God’s Name: Islamic Law, Authority and Women. Abou El Fadl, Khaled. Oxford: One World Publications, 2001, 361 pp. The Clash of Fundamentalisms: Crusades, Jihads and Modernity. Tariq Ali. Verson, April 2002, 160 pp. Unholy War: Terror in the Name of Islam. John L. Esposito. Oxford University Press Inc., March 2002, 208 pp. Virtually Islamic: Computer-Mediated Communication and Cyber-Islamic Environments. Gary Bunt. London, UK: University of Wales Press, 2000, 199 pp. Jihad: The Trail of Political Islam. Gilles Kepel. Translated By Anthony F. Roberts. Harvard University Press: Cambridge, Massachusetts. 2002, 454 pp. What’s So Great About America. Dinesh D’souza. Washington, DC: Regnery Publishing, Inc. 2002, 256 pages. Sword of Islam: Muslim Extremism from the Arab Conquests to the Attack on America. John F. Murphy Jr. Amherst, N.Y: Prometheus Books. 2002, 424 pages. Body of Secrets: Anatomy of The Ultra-Secret National Security Agency. James Bamford. New York: First Anchor Books Edition, 2002, 763 pages. للحصول على كامل المقالة مجانا يرجى النّقر على ملف ال PDF في اعلى يمين الصفحة.
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Schniering, J., M. Maciukiewicz, H. Gabrys, M. Brunner, C. Blüthgen, O. Distler, M. Guckenberger, T. Frauenfelder, S. Tanadini-Lang, and B. Maurer. "SAT0569 “IMAGES ARE MORE THAN PICTURES, THEY ARE DATA” [1] – EXPLORATION OF RADIOMICS ANALYSIS FOR SYSTEMIC SCLEROSIS-ASSOCIATED INTERSTITIAL LUNG DISEASE." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 1242.2–1243. http://dx.doi.org/10.1136/annrheumdis-2020-eular.928.

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Background:Interstitial lung disease (ILD) affects 60% of patients with systemic sclerosis (SSc) and is the primary cause of death. Medical imaging is an integral part of the routine work-up for diagnosis and monitoring of SSc-ILD and includes high-resolution computed tomography (HRCT). Radiomics is a novel research area that describes the in-depth analysis of tissue phenotypes in medical images with computational retrieval of quantitative, mineable metadata appropriate for statistical analyses.Objectives:To explore the performance of HRCT-derived radiomic features for the assessment of SSc-associated ILD (i.e. diagnosis, staging, and lung function).Methods:Radiomics analysis was performed on HRCT scans from 98 SSc patients, including n=33 SSc patients without ILD, n=33 with limited and n=32 with extensive ILD as defined by 0%, <20% and ≥20% visual extent of fibrosis on HRCT, respectively. Following semi-automated segmentation of lung tissue on 3D reconstructed HRCT scans, 1386 radiomic features, including 17 intensity, 137 texture, and 1232 wavelet features were extracted using the in-house developed software Z-Rad (Python 2.7). In order to identify robust features, we conducted intra- and inter-reader correlation analysis (ICC) in a subgroup of patients. Only features with good reproducibility (ICC ≥ 0.75) entered subsequent analyses. We applied the Wilcoxon test, followed by Receiver Operating Characteristic ROC) curve analyses, to identify features significantly different between a) ILD and non-ILD and b) limited vs. extensive ILD patients. Spearman rank correlation was performed to reveal significant associations of radiomic features from a) and b) with lung function as measured by percentage of predicted forced vital capacity (FVC% predicted).Results:In total, 1355/1386 radiomic features passed the test of robustness and were eligible for further, exploratory analyses. Radiomic features with good performance (area under the ROC curve (AUC) ≥ 0.7 and p-value ≤ 0.05) were considered as potential candidate discriminators. Under this criterion, we identified 288/1355 (21.3%) radiomic features that were significantly different between ILD and non-ILD patients and 409/1355 (30.2%) features that significantly discriminated between limited and extensive ILD (Fig. 1). For diagnosis, the texture featuredependence count entropywas the top parameter to distinguish ILD patients from healthy controls (AUC = 0.89, p = 1.83x10-10), whereas for staging the wavelet featureHHH long run high grey level emphasisproved to be best suited to separate limited from extensive ILD (AUC = 0.88, p = 7.76x10-9).Fig 1.Correlation analysis of the most significant (best performing) discriminative radiomic features with lung function revealed a significant negative correlation ofdependence count entropy(rho = -0.51, p = 9.89x10-8) andHHH long run high grey level emphasis(rho = -0.51, p = 1.73x10-5) with FVC% predicted.Conclusion:Our study adds novelty to the field of SSc-ILD showing that radiomic features have great potential as quantitative imaging biomarkers for diagnosis and staging of SSc-ILD and that they may reflect lung function. As the next step, we are planning to build predictive models, using machine learning, for diagnosis, staging, and lung function and validate them in external patient cohorts. If validated such models will pave the way for computer-aided management in SSc-ILD and thus improve patients’ outcome.References:[1]Gillies, R. J., Kinahan, P. E. & Hricak, H. Radiomics: Images Are More than Pictures, They Are Data. Radiology 278, 563-577, doi:10.1148/radiol.2015151169 (2016).Disclosure of Interests:Janine Schniering: None declared, Malgorzata Maciukiewicz: None declared, Hubert Gabrys: None declared, Matthias Brunner: None declared, Christian Blüthgen: None declared, Oliver Distler Grant/research support from: Grants/Research support from Actelion, Bayer, Boehringer Ingelheim, Competitive Drug Development International Ltd. and Mitsubishi Tanabe; he also holds the issued Patent on mir-29 for the treatment of systemic sclerosis (US8247389, EP2331143)., Consultant of: Consultancy fees from Actelion, Acceleron Pharma, AnaMar, Bayer, Baecon Discovery, Blade Therapeutics, Boehringer, CSL Behring, Catenion, ChemomAb, Curzion Pharmaceuticals, Ergonex, Galapagos NV, GSK, Glenmark Pharmaceuticals, Inventiva, Italfarmaco, iQvia, medac, Medscape, Mitsubishi Tanabe Pharma, MSD, Roche, Sanofi and UCB, Speakers bureau: Speaker fees from Actelion, Bayer, Boehringer Ingelheim, Medscape, Pfizer and Roche, Matthias Guckenberger: None declared, Thomas Frauenfelder: None declared, Stephanie Tanadini-Lang: None declared, Britta Maurer Grant/research support from: AbbVie, Protagen, Novartis, congress support from Pfizer, Roche, Actelion, and MSD, Speakers bureau: Novartis
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Giles, Frank, Sarina A. Piha-Paul, Alexander I. Spira, Fadi Braiteh, Julio Antonio Peguero, Daniel L. Spitz, James A. Knost, et al. "The Signature Program, a Distinctive Tissue Agnostic Trial Model for Molecularly Pre-Selected Hematological and Solid Tumor Patients." Blood 124, no. 21 (December 6, 2014): 4818. http://dx.doi.org/10.1182/blood.v124.21.4818.4818.

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Abstract Introduction: Here we describe a novel signal-finding clinical trial protocol series, termed the Novartis “Signature” program. These are tissue-agnostic, genetic alteration (mutation, amplification, translocation, etc.) specific protocols that do not include pre-identified clinical trial sites. In part these are responsive to the increased frequency of molecular profiling in the oncology community, and the incidence of patients whose tumors are identified with actionable genetic alteration yet without automatic access to drugs targeting those alterations. As these patients are identified via standard of care physician-directed profiling, we bring the ‘Protocol to the Patient’, utilizing a rapid study start-up process, such that a de novo site can have one of these trials opened within weeks of the originating patient being identified. Currently the 8 open single agent protocols involve buparlisib (BKM120, PI3Ki), dovitinib (TKI258, multi-kinase inhibitor), binimetinib (MEK162, MEKi), encorafenib (LGX818, RAFi), LEE011 (CDK4/6i), BGJ398 (FGFRi), ceritinib (LDK378, ALKi) and sonidegib (LDE225; SMOi). Methods:Patients with advanced solid and hematologic cancers and no established standard therapy options are eligible. Patients are locally pre-identified with an actionable genetic alteration relevant to the particular compound being studied; a local test done in a CLIA laboratory is sufficient for eligibility. Central broad molecular profiling of patient’s tumors (including confirmatory analysis of inclusion genetic alteration) is performed post-hoc using a fresh or archived sample. The primary objective of these trials is to assess clinical benefit (SD or better for ≥ 16 weeks for solid tumors or appropriate hematologic criteria) associated with the study related compound. A novel statistical design is incorporated to adaptively cluster patients of like indications into cohorts for independent analysis for futility (minimum 10 patients) or efficacy (minimum 15 patients). Rare tumors of at least 4 patients can be clustered together into unique cohorts for determination of signals. To investigate mechanisms of resistance, an optional biopsy is taken upon progression for patients who have had a prior response to the study compound – these tissues are subjected to a broad molecular profiling analysis. Results: Between March 2013 - July 2014, 13 academic centers and another 74 unique community/network sites had screened 286 patients. On average the startup timelines were 5.2 weeks across the program. 147 patients with a genetic alteration received matched therapy and have been dosed: primarily colorectal (28; 19%), NSCLC (25; 17%), ovarian (13; 9%) and sarcoma (n=12; 8%). Rare tumors accrued include small intestine/duodenal (n=6), anal (n=3), thymus (n=2), cholangiocarcinoma (n=2) and appendix (n=2). The Signature program also accrued heme malignancies. Across the whole program, the identifying actionable alterations were mainly PIK3CA (35%), PTEN loss (23%), RAS (18%), NF1 (4.7%), and FGFR2 (3.5%), and also included BRAF, SMO, PTCH1, VEGFR2, RET, PDGFRa, PDGFRb, TRKa, FGFR3, MEK1 and FLT3. The median number of lines of prior treatment was 3 (mean = 3.4; range of 1 to 13), median patient age of 61 years (range of 22 to 82), 40.3 % male, ECOG PS of 0 in 38% of patients and ECOG PS of 1 in 61.5% of patients. Three patients with AML harboring RAS mutations and one patient with multiple myeloma with a BRAFV600E mutation were included in the binimetinib module. (3 female / 1 male; 1-6 prior lines of therapy; 31-80 years old. One AML patient received prior transplant). Additional data will be presented. Futility/Efficacy analyses for 5 cohorts (4 from buparlisib and 1 from binimetinib) are currently ongoing. Conclusions: This program effectively allows the enrollment of molecularly profiled patients with genetic alterations linked to cognate targeted agents. The cohort analysis will evaluate clinical activity in multiple tumor types in parallel. The Signature program could enable the identification of clinical signals using patient sparing designs, potentially leading to subsequent confirmatory trials. This trial model has successfully allowed enrollment of molecularly pre-selected rare tumors in a short timeline without pre-determined trial site selection. The next step of this model will include novel drug combination modules. Disclosures Giles: Novartis: Consultancy, Research Funding. Off Label Use: Ceritinib is approved for the treatment of patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC), who have progressed on or who are intolerant to crizotinib. Here, ceritinib is being evaluated in other tumor types that express ALK mutations. All other agents are investigational.. Braiteh:Bayer: Consultancy, Speakers Bureau; Agendia: Consultancy; Incyte: Consultancy, Speakers Bureau; Genomic Health: Consultancy, Speakers Bureau; Foundation Medicine: Consultancy; Celgene: Consultancy, Speakers Bureau; Caris Life Sciences: Consultancy, Speakers Bureau; BMS: Consultancy, Speakers Bureau; Amgen/Onyxx: Consultancy, Speakers Bureau; INSYS: Consultancy, Speakers Bureau; Novartis: Consultancy, Speakers Bureau; Pfizer: Consultancy, Speakers Bureau; Saladax: Consultancy; Sanofi: Consultancy, Speakers Bureau. Schwartzberg:Novartis: Honoraria, Speakers Bureau. Stein:Novartis: Employment, Equity Ownership. Salvado:Novartis: Employment. Lebedinsky:Novartis: Employment. Kang:Novartis: Employment. Slosberg:Novartis: Employment.
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Giocoli, Nicola. "The (Rail)Road to Lochner: Reproduction Cost and the Gilded Age Controversy on Rate Regulation." SSRN Electronic Journal, 2015. http://dx.doi.org/10.2139/ssrn.2599032.

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