Academic literature on the topic 'GlycoGag'

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Journal articles on the topic "GlycoGag"

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Fujisawa, Ryuichi, Frank J. McAtee, Cynthia Favara, Stanley F. Hayes, and John L. Portis. "N-Terminal Cleavage Fragment of Glycosylated Gag Is Incorporated into Murine Oncornavirus Particles." Journal of Virology 75, no. 22 (2001): 11239–43. http://dx.doi.org/10.1128/jvi.75.22.11239-11243.2001.

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ABSTRACT Glycosylated Gag (Glycogag) is a transmembrane protein encoded by murine and feline oncornaviruses. While the protein is dispensible for virus replication, Glycogag-null mutants of a neurovirulent murine oncornavirus are slow to spread in vivo and exhibit a loss of pathogenicity. The function of this protein in the virus life cycle, however, is not understood. Glycogag is expressed at the plasma membrane of infected cells but has not been detected in virions. In the present study we have reexamined this issue and have found an N-terminal cleavage fragment of Glycogag which was pellete
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Usami, Yoshiko, Yuanfei Wu, and Heinrich G. Göttlinger. "SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef." Nature 526, no. 7572 (2015): 218–23. https://doi.org/10.5281/zenodo.13533229.

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(Uploaded by Plazi for the Bat Literature Project) HIV-1 Nef and the unrelated mouse leukaemia virus glycosylated Gag (glycoGag) strongly enhance the infectivity of HIV-1 virions produced in certain cell types in a clathrin-dependent manner. Here we show that Nef and glycoGag prevent the incorporation of the multipass transmembrane proteins serine incorporator 3 (SERINC3) and SERINC5 into HIV-1 virions to an extent that correlates with infectivity enhancement. Silencing of both SERINC3 and SERINC5 precisely phenocopied the effects of Nef and glycoGag on HIV-1 infectivity. The infectivity of ne
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Usami, Yoshiko, Yuanfei Wu, and Heinrich G. Göttlinger. "SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef." Nature 526, no. 7572 (2015): 218–23. https://doi.org/10.5281/zenodo.13533229.

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(Uploaded by Plazi for the Bat Literature Project) HIV-1 Nef and the unrelated mouse leukaemia virus glycosylated Gag (glycoGag) strongly enhance the infectivity of HIV-1 virions produced in certain cell types in a clathrin-dependent manner. Here we show that Nef and glycoGag prevent the incorporation of the multipass transmembrane proteins serine incorporator 3 (SERINC3) and SERINC5 into HIV-1 virions to an extent that correlates with infectivity enhancement. Silencing of both SERINC3 and SERINC5 precisely phenocopied the effects of Nef and glycoGag on HIV-1 infectivity. The infectivity of ne
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Gonzalez-Enriquez, Gracia Viviana, Martha Escoto-Delgadillo, Eduardo Vazquez-Valls, and Blanca Miriam Torres-Mendoza. "SERINC as a Restriction Factor to Inhibit Viral Infectivity and the Interaction with HIV." Journal of Immunology Research 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/1548905.

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The serine incorporator 5 (SERINC5) is a recently discovered restriction factor that inhibits viral infectivity by preventing fusion. Retroviruses have developed strategies to counteract the action of SERINC5, such as the expression of proteins like negative regulatory factor (Nef), S2, and glycosylated Gag (glycoGag). These accessory proteins downregulate SERINC5 from the plasma membrane for subsequent degradation in the lysosomes. The observed variability in the action of SERINC5 suggests the participation of other elements like the envelope glycoprotein (Env) that modulates susceptibility o
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Firrito, Claudia, Cinzia Bertelli, Teresa Vanzo, Ajit Chande, and Massimo Pizzato. "SERINC5 as a New Restriction Factor for Human Immunodeficiency Virus and Murine Leukemia Virus." Annual Review of Virology 5, no. 1 (2018): 323–40. http://dx.doi.org/10.1146/annurev-virology-092917-043308.

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SERINC genes encode for homologous multipass transmembrane proteins with unknown cellular function, despite being highly conserved across eukaryotes. Among the five SERINC genes found in humans, SERINC5 was shown to act as a powerful inhibitor of retroviruses. It is efficiently incorporated into virions and blocks the penetration of the viral core into target cells, by impairing the fusion process with a yet unclear mechanism. SERINC5 was also found to promote human immunodeficiency virus 1 (HIV-1) virion neutralization by antibodies, indicating a pleiotropic activity, which remains mostly une
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Cano-Ortiz, Lucía, Qinyong Gu, Patricia de Sousa-Pereira, et al. "Feline Leukemia Virus-B Envelope Together With its GlycoGag and Human Immunodeficiency Virus-1 Nef Mediate Resistance to Feline SERINC5." Journal of Molecular Biology 434, no. 6 (2022): 167421. http://dx.doi.org/10.1016/j.jmb.2021.167421.

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Shi, Yuhang, Sydney Simpson, Shahad K. Ahmed, et al. "The Antiviral Factor SERINC5 Impairs the Expression of Non-Self-DNA." Viruses 15, no. 9 (2023): 1961. http://dx.doi.org/10.3390/v15091961.

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SERINC5 is a restriction factor that becomes incorporated into nascent retroviral particles, impairing their ability to infect target cells. In turn, retroviruses have evolved countermeasures against SERINC5. For instance, the primate lentiviruses (HIV and SIV) use Nef, Moloney Murine Leukemia Virus (MLV) uses GlycoGag, and Equine Infectious Anemia Virus (EIAV) uses S2 to remove SERINC5 from the plasma membrane, preventing its incorporation into progeny virions. Recent studies have shown that SERINC5 also restricts other viruses, such as Hepatitis B Virus (HBV) and Classical Swine Fever Virus
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Diehl, William E., Mehmet H. Guney, Teresa Vanzo, et al. "Influence of Different Glycoproteins and of the Virion Core on SERINC5 Antiviral Activity." Viruses 13, no. 7 (2021): 1279. http://dx.doi.org/10.3390/v13071279.

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Host plasma membrane protein SERINC5 is incorporated into budding retrovirus particles where it blocks subsequent entry into susceptible target cells. Three structurally unrelated proteins encoded by diverse retroviruses, human immunodeficiency virus type 1 (HIV-1) Nef, equine infectious anemia virus (EIAV) S2, and ecotropic murine leukemia virus (MLV) GlycoGag, disrupt SERINC5 antiviral activity by redirecting SERINC5 from the site of virion assembly on the plasma membrane to an internal RAB7+ endosomal compartment. Pseudotyping retroviruses with particular glycoproteins, e.g., vesicular stom
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Li, Minghua, Abdul A. Waheed, Jingyou Yu, et al. "TIM-mediated inhibition of HIV-1 release is antagonized by Nef but potentiated by SERINC proteins." Proceedings of the National Academy of Sciences 116, no. 12 (2019): 5705–14. http://dx.doi.org/10.1073/pnas.1819475116.

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The T cell Ig and mucin domain (TIM) proteins inhibit release of HIV-1 and other enveloped viruses by interacting with cell- and virion-associated phosphatidylserine (PS). Here, we show that the Nef proteins of HIV-1 and other lentiviruses antagonize TIM-mediated restriction. TIM-1 more potently inhibits the release of Nef-deficient relative to Nef-expressing HIV-1, and ectopic expression of Nef relieves restriction. HIV-1 Nef does not down-regulate the overall level of TIM-1 expression, but promotes its internalization from the plasma membrane and sequesters its expression in intracellular co
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Chande, Ajit, Emilia Cristiana Cuccurullo, Annachiara Rosa, Serena Ziglio, Susan Carpenter, and Massimo Pizzato. "S2 from equine infectious anemia virus is an infectivity factor which counteracts the retroviral inhibitors SERINC5 and SERINC3." Proceedings of the National Academy of Sciences 113, no. 46 (2016): 13197–202. http://dx.doi.org/10.1073/pnas.1612044113.

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The lentivirus equine infectious anemia virus (EIAV) encodes the small protein S2, a pathogenic determinant that is important for virus replication and disease progression in horses. No molecular function had been linked to this accessory protein. We report that S2 can replace the activity of Negative factor (Nef) in HIV-1 infectivity, being required to antagonize the inhibitory activity of Serine incorporator (SERINC) proteins on Nef-defective HIV-1. Like Nef, S2 excludes SERINC5 from virus particles and requires an ExxxLL motif predicted to recruit the clathrin adaptor, Adaptor protein 2 (AP
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Dissertations / Theses on the topic "GlycoGag"

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Bertelli, Cinzia. "Antiviral activity and retroviral counteraction of SERINC genes." Doctoral thesis, Università degli studi di Trento, 2021. http://hdl.handle.net/11572/321392.

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SERINC5 is a restriction factor for retroviruses, antagonized by Nef of primate lentiviruses, by glycoGag of Moloney Murine Leukaemia Virus (MoMLV) and by S2 of Equine Infectious Anaemia virus (EIAV). In addition, SERINC5 sensitizes HIV-1 to neutralizing antibodies (nAbs) targeting the MPER in gp41. However, since the identification of SERINC5 as an inhibitor of retrovirus infectivity, many features of the host factor await clarification, notably the molecular mechanisms of restriction and viral counteraction. Furthermore, SERINC5 cellular role beyond restriction is still obscure. This thesis
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Syed, Noor Afshan. "Regulation of glycogen synthase and glycogen phosphorylase by insulin in HepG2 cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/NQ63926.pdf.

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Martin, Jennifer Louise. "Molecular interactions involving glycogen phosphorylase." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.253306.

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Ghosh, Paritosh. "De Novo Glycogen Biosynthesis by a Glycogen Primer Complex in the Obliquely Striated Skeletal Muscle of Ascaris suum." Thesis, North Texas State University, 1987. https://digital.library.unt.edu/ark:/67531/metadc935639/.

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During the purification of the enzyme glycogen synthase from the muscle of the nematode Ascaris suum, approximately 70% of the glycogen synthase activity can be separated from the bulk of cellular glycogen by centrifugation for 60 min at 105,000 x . The glycogen synthase in the supernatant fraction has an Mr of 1.2 x 106 as determined by Sepharose 4B gel filtration chromatography. The glycogen synthase in this high molecular weight complex (glycogen primer complex) can be further purified by ConA-Sepharose affinity chromatography; the enzyme activity was eluted with 100 .mM a-methylmannoside.
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Karis, Nils David. "Design and Synthesis of 1,3-Disubstitiuted-2-Pyridones as a New Class of Glycogen Phosphorylase Inhibitors." Thesis, Griffith University, 2009. http://hdl.handle.net/10072/365791.

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Glycogen Phosphorylase (GP) is the regulatory enzyme that catalyses the first step in glycogen degradation and is a potential enzyme target for therapeutic intervention in the treatment of diabetes. The 16 amino acid C-terminal sequence of human Gl is the only known targeting subunit that binds to GPa. Blocking the interactions between Gl and GPa should reduce high blood glucose levels in a diabetic person. A segment of the 16 amino acid segment was chosen for a small molecule peptidomimetric approach, and de nova design from this segment identified the pyridone ring as apotential scaffold. Th
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Street, Ian Philip. "Protein - carbohydrate interactions in glycogen phosphorylase." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/25049.

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It has long been observed that some organo-fluorine compounds exhibit enhanced biological activity over their non-fluorinated precursors, however reasons for these unusual properties still remain poorly understood. An explanation which has been widely used relates to the ability of the C-F fragment of the analog to participate in hydrogen-bonding interactions with its protein receptor. For this reason, fluorinated carbohydrates have been used as hydrogen-bonding probes with a number of proteins. Thus there exists a need for a systematic investigation into the hydrogen-bonding ability of the C
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Stambolic, Vuk. "Regulation of glycogen synthase kinase-3." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0003/NQ27730.pdf.

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Fraser, Bernadine Heather. "Glycogen and glucose metabolism in cardioprotection." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0028/NQ34764.pdf.

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Henning, Sarah Louise. "Myocardial glycogen metabolism and its regulation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ61107.pdf.

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Barford, D. "Crystallographic studies on glycogen phosphorylase b." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233473.

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Books on the topic "GlycoGag"

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DiNuzzo, Mauro, and Arne Schousboe, eds. Brain Glycogen Metabolism. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-27480-1.

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Savage, Madelyn. The Avian Glycogen body. University of Salford, 1986.

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R, Acharya K., ed. Glycogen phosphorylase b: Description of the protein structure. World Scientific, 1991.

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Martinez, Ana, Ana Castro, and Miguel Medina, eds. Glycogen Synthase Kinase 3 (GSK-3) and Its Inhibitors. John Wiley & Sons, Inc., 2006. http://dx.doi.org/10.1002/0470052171.

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Ajit, Varki, ed. Essentials of glycobiology. 2nd ed. Cold Spring Harbor Laboratory Press, 2008.

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Plomp, Peter. Autophagy in hepatocytes: Energy dependence and relation to glycogen synthesis. Univ., 1989.

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library, Wiley online, ed. Glycogen synthase kinase 3 (GSK-3) and its inhibitors: Drug discovery and development. Wiley-Interscience, 2006.

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Patel, Mona D. Abnormalities in glycogen storage and metabolism in patients with liver-related diseases. University of Surrey Roehampton, 2002.

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Clement, Nichole S. The effects of the neurotoxin tetrodotoxin on glycogen content in rat soleus muscles. Laurentian University, 1993.

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Seal, Leonard Henry. Studies on glycogen in the nervous systems of Haemopis Sanguisuga and Planorbis Corneus. University of Salford, 1986.

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Book chapters on the topic "GlycoGag"

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Peck, Stewart B., Carol C. Mapes, Netta Dorchin, et al. "Glycogen." In Encyclopedia of Entomology. Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6359-6_1122.

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Pavelka, Margit, and Jürgen Roth. "Glycogen." In Functional Ultrastructure. Springer Vienna, 2010. http://dx.doi.org/10.1007/978-3-211-99390-3_73.

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Wagner, Peter, Frank C. Mooren, Hidde J. Haisma, et al. "Glycogen." In Encyclopedia of Exercise Medicine in Health and Disease. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-29807-6_2449.

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Bährle-Rapp, Marina. "Glycogen." In Springer Lexikon Kosmetik und Körperpflege. Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-71095-0_4411.

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Madsen, Neil B. "Glycogen Phosphorylase and Glycogen Synthetase." In A Study of Enzymes, Volume II. CRC Press, 2024. https://doi.org/10.1201/9781003575023-7.

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Wagner, Peter, Frank C. Mooren, Hidde J. Haisma, et al. "Glycogen Depletion." In Encyclopedia of Exercise Medicine in Health and Disease. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-29807-6_2447.

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Wagner, Peter, Frank C. Mooren, Hidde J. Haisma, et al. "Glycogen Synthase." In Encyclopedia of Exercise Medicine in Health and Disease. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-29807-6_2448.

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Meigs, Thomas E., Alex Lyakhovich, Hoon Shim, et al. "Glycogen Synthase." In Encyclopedia of Signaling Molecules. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_100544.

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Wagner, Peter, Frank C. Mooren, Hidde J. Haisma, et al. "Glycogen Loading." In Encyclopedia of Exercise Medicine in Health and Disease. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-29807-6_4246.

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Cavaglieri, Cláudia Regina, Carlos Alberto da Silva, and Celene Fernandes Bernardes. "Glycogen Measurement." In Basic Protocols in Foods and Nutrition. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2345-9_9.

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Conference papers on the topic "GlycoGag"

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Karunakaran, Varsha, Ruud P. M. Dings, and Narasimhan Rajaram. "Investigating Biomarkers of Radiation Resistance in Head and Neck Cancer Using Raman Spectroscopy." In Clinical and Translational Biophotonics. Optica Publishing Group, 2025. https://doi.org/10.1364/translational.2025.tm1f.1.

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Raman spectroscopy was applied to monitor early tumor biomolecular changes in sensitive and resistant head and neck cancer. Raman contributions from glycogen could provide a potential biomarker of radiation resistance.
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Tretyakova, A. M., and N. A. Vakhnina. "Application of the phenol-sulfuric acid method for the determination of glycogen in skeletal muscles and liver of rats." In VIII Vserossijskaja konferencija s mezhdunarodnym uchastiem «Mediko-fiziologicheskie problemy jekologii cheloveka». Publishing center of Ulyanovsk State University, 2021. http://dx.doi.org/10.34014/mpphe.2021-189-191.

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The possibility of using the phenol-sulfuric acid method for the determination of total glycogen, its acid-soluble and acid-insoluble fractions in the liver and skeletal muscles of rats was studied. It was found that the use of a precipitant in the isolation of total glycogen and its fractions increases the yield of the investigated substances.
 Key words: phenol-sulfate method, rats, liver, muscles, total glycogen, acid-soluble glycogen, acid-insoluble glycogen.
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Alvarenga, F. A. P., I. J. Lean, and P. McGilchrist. "Impact of dietary potassium levels on muscle glycogen concentration." In 6th EAAP International Symposium on Energy and Protein Metabolism and Nutrition. Wageningen Academic Publishers, 2019. http://dx.doi.org/10.3920/978-90-8686-891-9_117.

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Schumacher, A., C. Metzendorf, S. Ribback, and F. Dombrowski. "Investigation of the glycogen-associated proteome via proximity-biotinylation." In 36. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber. Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0039-3402193.

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"Expression of glycogen synthase kinase 3β in nephrotic syndrome". У Bioinformatics of Genome Regulation and Structure/ Systems Biology. institute of cytology and genetics siberian branch of the russian academy of science, Novosibirsk State University, 2020. http://dx.doi.org/10.18699/bgrs/sb-2020-343.

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Parker, K. J., T. A. Tuthill, and R. B. Baggs. "Ultrasound Attenuation of Glycogen: In Vitro and In Vivo Results." In IEEE 1987 Ultrasonics Symposium. IEEE, 1987. http://dx.doi.org/10.1109/ultsym.1987.199107.

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Altemus, Megan Ann, Joel A. Yates, ZhiFen Wu, LiWei Bao, and Sofia D. Merajver. "Abstract 1446: Glycogen accumulation in aggressive breast cancers under hypoxia." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-1446.

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Wieloch, Judith, Mandy Lemme, Janin Henkel, and GerhardP Püschel. "Direct impact of fructose on hepatic lipid and glycogen metabolism." In 38. Jahrestagung der Deutsche Arbeitsgemeinschaft zum Studium der Leber. Georg Thieme Verlag, 2022. http://dx.doi.org/10.1055/s-0041-1740655.

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Altemus, Megan, Joel Yates, ZhiFen Wu, LiWei Bao, and Sofia Merajver. "Abstract 433: Glycogen accumulation in aggressive breast cancers during hypoxic exposure." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-433.

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Álvarez-Santos, Mayra D., Marisol Alvarez-González, Elizabeth Eslava-De Jesus, et al. "Role of protein phosphatase 1 glycogen-associated regulatory subunit in asthma." In ERS International Congress 2018 abstracts. European Respiratory Society, 2018. http://dx.doi.org/10.1183/13993003.congress-2018.pa974.

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Reports on the topic "GlycoGag"

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Wolgamott, D. Storage and use of glycogen by juvenile Carcinonemertes errans. Portland State University Library, 2000. http://dx.doi.org/10.15760/etd.2966.

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Uni, Zehava, and Peter Ferket. Enhancement of development of broilers and poults by in ovo feeding. United States Department of Agriculture, 2006. http://dx.doi.org/10.32747/2006.7695878.bard.

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The specific objectives of this research were the study of the physical and nutritional properties of the In Ovo Feeding (IOF) solution (i.e. theosmostic properties and the carbohydrate: protein ratio composition). Then, using the optimal solution for determining its effect on hatchability, early nutritional status and intestinal development of broilers and turkey during the last quarter of incubation through to 7 days post-hatch (i.e. pre-post hatch period) by using molecular, biochemical and histological tools. The objective for the last research phase was the determination of the effect of
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Osman, Mohamed, Portia Allen, Nimer Mehyar, Gerd Bobe, Johann Coetzee, and Donald C. Beitz. Acute Effects of Postpartal Subcutaneous Injection of Glucagon and/or Oral Administration of Glycerol on Blood Metabolites and Hormones and Liver Lipids and Glycogen of Holstein Dairy Cows Induced with Fatty Liver Disease. Iowa State University, 2007. http://dx.doi.org/10.31274/ans_air-180814-754.

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